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| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |
|---|---|---|---|---|---|---|---|
| 1bzf | TMQ | Trimetrexate (DB01157) | Trimetrexate is a folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin. | DIHYDROFOLATE REDUCTASE (Lactobacillus casei) | NA | ||
| 1j3j | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Plasmodium falciparum) | DHFR_1 | ||
| 1jom | FFO | Levoleucovorin (DB11596) | Levoleucovorin is a folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer. | DIHYDROFOLATE REDUCTASE (Escherichia coli) | DHFR_1 | ||
| 2bl9 | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Plasmodium vivax) | DHFR_1 | ||
| 2w3a | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Homo sapiens) | DHFR_1 | ||
| 2w3v | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Mycobacterium avium) | DHFR_1 | ||
| 2w9h | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Staphylococcus aureus) | DHFR_1 | ||
| 2w9s | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003 (Staphylococcus aureus) | DHFR_1 | ||
| 3fl9 | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (DHFR) (Bacillus anthracis) | DHFR_1 | ||
| 3nrr | D16 | Raltitrexed (DB00293) | Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer. | DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Babesia bovis) | DHFR_1Thymidylat_synt | ||
| 3qfx | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Trypanosoma brucei rhodesiense) | DHFR_1 | ||
| 3tq8 | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Coxiella burnetii) | DHFR_1 | ||
| 4g8z | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Pneumocystis jirovecii) | DHFR_1 | ||
| 4km0 | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | DIHYDROFOLATE REDUCTASE (Mycobacterium tuberculosis) | DHFR_1 | ||
| 4km2 | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Mycobacterium tuberculosis) | DHFR_1 | ||
| 4m2x | TMQ | Trimetrexate (DB01157) | Trimetrexate is a folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin. | DIHYDROFOLATE REDUCTASE (Mycobacterium tuberculosis) | DHFR_1 | ||
| 5uih | 8CV | Phenformin (DB00914) | A biguanide hypoglycemic agent with actions and uses similar to those of metformin. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often... | DIHYDROFOLATE REDUCTASE (Escherichia coli) | DHFR_1 | ||
| 6aog | CP6 | Pyrimethamine (DB00205) | Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. | BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasma gondii) | Thymidylat_synt | ||
| 6xg5 | TOP | Trimethoprim (DB00440) | Trimethoprim is an antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. | DIHYDROFOLATE REDUCTASE (Escherichia coli (strain k12)) | DHFR_1 | ||
| PDB | Ligand | Drug | Indication | Macromolecule/ Organism |
Pfam | Binding_Interfaces (View) | Details |