LIST OF BINDING INTERFACES for query 'diabetes' in category 'DRUG INDICATION'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
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PDB	Ligand	Drug	Indication	Macromolecule/ Organism	Pfam	Binding_Interfaces (View)	Details
1x70	715	Sitagliptin (DB01261)	Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used for the management of type 2 diabetes mellitus.	DIPEPTIDYL PEPTIDASE IV (Homo sapiens)	DPPIV_N Peptidase_S9	1X70_A_715A801	Details
2rgu	356	Linagliptin (DB08882)	Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus.	DIPEPTIDYL PEPTIDASE 4 (Homo sapiens)	DPPIV_N Peptidase_S9	2RGU_A_356A901	Details
2v85	NMM	Tilarginine (DB11815)	Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.	H3R2ME1K4ME3 PEPTIDE; VDJ RECOMBINATION-ACTIVATING PROTEIN 2 (Mus musculus; synthetic construct)	NA	2V85_D_NMMD2	Details
3g0b	T22	Alogliptin (DB06203)	Alogliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat hyperglycemia in patients with type 2 diabetes mellitus.	DIPEPTIDYL PEPTIDASE 4 (Homo sapiens)	DPPIV_N Peptidase_S9	3G0B_A_T22A800	Details
3kb7	NMM	Tilarginine (DB11815)	Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.	SERINE/THREONINE-PROTEIN KINASE PLK1 (Homo sapiens)	Pkinase	3KB7_A_NMMA324	Details
4ffw	715	Sitagliptin (DB01261)	Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used for the management of type 2 diabetes mellitus.	DIPEPTIDYL PEPTIDASE 4 (Rattus norvegicus; mus musculus)	DPPIV_N Peptidase_S9	4FFW_A_715A801	Details
4kuk	NMM	Tilarginine (DB11815)	Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.	BLUE-LIGHT PHOTORECEPTOR (Dinoroseobacter shibae)	PAS_9	4KUK_A_NMMA97	Details
4yvp	GBM	Glyburide (DB01016)	Glyburide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.	ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 (Homo sapiens)	Aldo_ket_red	4YVP_A_GBMA402	Details
4yvv	GBM	Glyburide (DB01016)	Glyburide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.	ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens)	Aldo_ket_red	4YVV_A_GBMA402	Details
4yvx	GMR	Glimepiride (DB00222)	Glimepiride is a sulfonylurea drug used to treat type 2 diabetes mellitus.	ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens)	Aldo_ket_red	4YVX_A_GMRA401	Details
4zfc	GCZ	Gliclazide (DB01120)	Gliclazide is a sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus.	ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens)	Aldo_ket_red	4ZFC_A_GCZA402	Details
5dwq	NMM	Tilarginine (DB11815)	Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.	HISTONE-ARGININE METHYLTRANSFERASE CARM1; METHYLATED H3 PEPTIDE (Homo sapiens; synthetic construct)	PrmA	5DWQ_F_NMMF5	Details
5g5j	MF8	Metformin (DB00331)	Metformin is a biguanide drug used in conjunction with diet and exercise for glycemic control in type 2 diabetes mellitus and used off-label for insulin resistance in polycystic ovary syndrome (PCOS).	CYTOCHROME P450 3A4 (Homo sapiens)	p450	5G5J_A_MF8A600	Details
5ifu	GBM	Glyburide (DB01016)	Glyburide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.	PROLINE--TRNA LIGASE (Plasmodium falciparum (isolate 3d7))	HGTP_anticodon ProRS-C_1 tRNA-synt_2b	5IFU_A_GBMA801	Details
5va6	NMM	Tilarginine (DB11815)	Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.	HISTONE H3.1; PROBABLE HISTONE-LYSINE N-METHYLTRANSFERASE ATXR5 (Ricinus communis; synthetic construct)	NA	5VA6_C_NMMC27	Details
5y2o	8N6	Pioglitazone (DB01132)	Pioglitazone is a thiazolidinedione used adjunctively with diet and exercise to normalize glycemic levels in adults with type 2 diabetes mellitus.	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens)	Hormone_recep	5Y2O_A_8N6A501	Details
6avs	NMM	Tilarginine (DB11815)	Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.	LYSINE-SPECIFIC DEMETHYLASE 8 (Homo sapiens)	Cupin_8	6AVS_A_NMMA502	Details
6b1e	LF7	Vildagliptin (DB04876)	Vildagliptin is a once-daily dipeptidyl peptidase 4 (DPP-4) inhibitor used in the management of type 2 diabetes mellitus.	DIPEPTIDYL PEPTIDASE 4 (Homo sapiens)	DPPIV_N Peptidase_S9	6B1E_A_LF7A801	Details
6baa	GBM	Glyburide (DB01016)	Glyburide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Rattus norvegicus; cricetus cricetus)	ABC_membrane ABC_tran	6BAA_E_GBME2001	Details
6jb3	BJX	Repaglinide (DB00912)	Repaglinide is a antihyperglycemic used to improve glycemic control in diabetes.	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 ISOFORM X2 (Mesocricetus auratus)	ABC_membrane ABC_tran	6JB3_B_BJXB2001	Details
6mev	NMM	Tilarginine (DB11815)	Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.	BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD6 (Homo sapiens)	JmjC	6MEV_A_NMMA403	Details
6oi1	NMM	Tilarginine (DB11815)	Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.	WD REPEAT-CONTAINING PROTEIN 5 (Homo sapiens)	WD40	6OI1_A_NMMA404	Details
6oi3	NMM	Tilarginine (DB11815)	Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.	MONOMETHYL H3R2 PEPTIDE; WD REPEAT-CONTAINING PROTEIN 5 (Homo sapiens; synthetic construct)	WD40	6OI3_B_NMMB2	Details
6y0f	356	Linagliptin (DB08882)	Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus.	PROLYL ENDOPEPTIDASE FAP (Homo sapiens)	DPPIV_N	6Y0F_A_356A806	Details
7awc	BRL	Rosiglitazone (DB00412)	Rosiglitazone is a thiazolidinedione indicated as an adjunct to diet and exercise to maintain glycemic control in type 2 diabetes.	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens)	Hormone_recep	7AWC_A_BRLA501	Details
PDB	Ligand	Drug	Indication	Macromolecule/ Organism	Pfam	Binding_Interfaces (View)	Details

[["1x70","715","Sitagliptin (DB01261)","Homo sapiens","DIPEPTIDYL PEPTIDASE IV","DPPIV_N;Peptidase_S9"],["2rgu","356","Linagliptin (DB08882)","Homo sapiens","DIPEPTIDYL PEPTIDASE 4","DPPIV_N;Peptidase_S9"],["2v85","NMM","Tilarginine (DB11815)","Mus musculus;synthetic construct","H3R2ME1K4ME3 PEPTIDE;VDJ RECOMBINATION-ACTIVATING PROTEIN 2","NA"],["3g0b","T22","Alogliptin (DB06203)","Homo sapiens","DIPEPTIDYL PEPTIDASE 4","DPPIV_N;Peptidase_S9"],["3kb7","NMM","Tilarginine (DB11815)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE PLK1","Pkinase"],["4ffw","715","Sitagliptin (DB01261)","Rattus norvegicus;mus musculus","DIPEPTIDYL PEPTIDASE 4","DPPIV_N;Peptidase_S9"],["4kuk","NMM","Tilarginine (DB11815)","Dinoroseobacter shibae","BLUE-LIGHT PHOTORECEPTOR","PAS_9"],["4yvp","GBM","Glyburide (DB01016)","Homo sapiens","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1","Aldo_ket_red"],["4yvv","GBM","Glyburide (DB01016)","Homo sapiens","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","Aldo_ket_red"],["4yvx","GMR","Glimepiride (DB00222)","Homo sapiens","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","Aldo_ket_red"],["4zfc","GCZ","Gliclazide (DB01120)","Homo sapiens","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","Aldo_ket_red"],["5dwq","NMM","Tilarginine (DB11815)","Homo sapiens;synthetic construct","HISTONE-ARGININE METHYLTRANSFERASE CARM1;METHYLATED H3 PEPTIDE","PrmA"],["5g5j","MF8","Metformin (DB00331)","Homo sapiens","CYTOCHROME P450 3A4","p450"],["5ifu","GBM","Glyburide (DB01016)","Plasmodium falciparum (isolate 3d7)","PROLINE--TRNA LIGASE","HGTP_anticodon;ProRS-C_1;tRNA-synt_2b"],["5va6","NMM","Tilarginine (DB11815)","Ricinus communis;synthetic construct","HISTONE H3.1;PROBABLE HISTONE-LYSINE N-METHYLTRANSFERASE ATXR5","NA"],["5y2o","8N6","Pioglitazone (DB01132)","Homo sapiens","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","Hormone_recep"],["6avs","NMM","Tilarginine (DB11815)","Homo sapiens","LYSINE-SPECIFIC DEMETHYLASE 8","Cupin_8"],["6b1e","LF7","Vildagliptin (DB04876)","Homo sapiens","DIPEPTIDYL PEPTIDASE 4","DPPIV_N;Peptidase_S9"],["6baa","GBM","Glyburide (DB01016)","Rattus norvegicus;cricetus cricetus","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","ABC_membrane;ABC_tran"],["6jb3","BJX","Repaglinide (DB00912)","Mesocricetus auratus","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 ISOFORM X2","ABC_membrane;ABC_tran"],["6mev","NMM","Tilarginine (DB11815)","Homo sapiens","BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD6","JmjC"],["6oi1","NMM","Tilarginine (DB11815)","Homo sapiens","WD REPEAT-CONTAINING PROTEIN 5","WD40"],["6oi3","NMM","Tilarginine (DB11815)","Homo sapiens;synthetic construct","MONOMETHYL H3R2 PEPTIDE;WD REPEAT-CONTAINING PROTEIN 5","WD40"],["6y0f","356","Linagliptin (DB08882)","Homo sapiens","PROLYL ENDOPEPTIDASE FAP","DPPIV_N"],["7awc","BRL","Rosiglitazone (DB00412)","Homo sapiens","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","Hormone_recep"]]