Potential binding sites containing seven residues derived from binding site similarity searches
DrReposER ID
Hit
Organism / Macromolecule
Interface
HETATM
RMSD
Dali Z-score
Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 163HIS A 165HIS A 182LEU A 259THR A 260THR A 261TRP A 270
ZN A 378 (-3.2A) ZN A 378 (-3.3A) ZN A 378 (-3.1A)None ZN A 378 ( 4.5A)NoneNone
0.24A
1am6A-3b1bA:24.9
1am6A-3b1bA:25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 117HIS A 119HIS A 136LEU A 201THR A 202THR A 203TRP A 212
ZN A 301 (-3.3A) ZN A 301 (-3.3A) ZN A 301 (-3.2A)None ZN A 301 (-4.4A)NoneNone
0.21A
1am6A-6ekiA:29.8
1am6A-6ekiA:16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 94HIS A 96HIS A 119LEU A 198THR A 199THR A 200TRP A 209
ZN A 301 ( 3.2A) ZN A 301 ( 3.2A) ZN A 301 ( 3.1A)V14 A 302 (-3.6A)V14 A 302 (-3.2A)V14 A 302 (-3.5A)None
0.36A
1am6A-6fe1A:33.6
1am6A-6fe1A:14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
SER A 148THR A 150ASN A 152CYH A 153TYR A 312ASN A 314TYR A 318
OCS A 149 ( 3.5A)OCS A 149 ( 3.8A)NoneNoneOCS A 149 ( 4.1A)NAD A 401 (-3.7A)NAD A 401 (-3.5A)
0.18A
1dssG-5ur0A:51.6
1dssG-5ur0A:undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
SER A 155THR A 157ASN A 159CYH A 160TYR A 318ASN A 320TYR A 324
NoneNoneNoneNoneNoneNAD A 401 (-3.7A)NAD A 401 (-3.6A)
0.18A
1dssG-5y37A:47.5
1dssG-5y37A:undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
SER A 150THR A 152ASN A 154CYH A 155TYR A 313ASN A 315TYR A 319
PO4 A 402 (-2.7A)PO4 A 402 (-3.1A)NoneNoneNoneNAD A 401 (-4.0A)NAD A 401 (-3.6A)
0.14A
1dssG-6dfzA:54.4
1dssG-6dfzA:undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
TRP A 245GLY A 279TYR A 282GLU A 359SER A 360PHE A 490HIS A 600
None
0.68A
2ackA-6arxA:64.8
2ackA-6arxA:13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
TRP A 245TYR A 282TYR A 291GLU A 359TYR A 489HIS A 600GLY A 601
SEB A 360 ( 4.2A)NoneNoneSEB A 360 ( 3.3A)NoneSEB A 360 ( 4.2A)None
0.38A
2ha4B-5ydjA:64.6
2ha4B-5ydjA:undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
TRP A 245TYR A 282TYR A 291GLU A 359TYR A 489HIS A 600GLY A 601
None
0.46A
2ha4B-6arxA:64.7
2ha4B-6arxA:undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
ARG A 60LYS A 205LYS A 206HIS A 225SER A 244ASP A 263ARG A 327
OXD A 543 (-4.1A)OXD A 543 ( 4.2A) MN A 999 ( 2.4A) MN A 999 (-3.4A)OXD A 543 ( 2.3A) MN A 999 (-2.5A)ATP A 541 ( 2.8A)
0.73A
2rk8B-1ytmA:29.2
2rk8B-1ytmA:23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
GLY A 9GLN A 11VAL A 42HIS A 45ASP A 135ILE A 136GLN A 150
TRP A 501 (-3.5A)TRP A 501 (-4.2A)TRP A 501 ( 4.6A)TRP A 501 (-4.0A)TRP A 501 (-3.9A)NoneTRP A 501 (-3.3A)
0.76A
3fi0P-6dfuA:38.6
3fi0P-6dfuA:undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
TYR A 405ASN A 567ILE A 582PHE A 586MET A 603GLN A 615PHE A 618
None9VE A 801 (-4.1A)9VE A 801 (-4.1A)9VE A 801 (-3.6A)9VE A 801 (-3.6A)9VE A 801 (-3.2A)9VE A 801 (-3.9A)
0.58A
3tvxB-5ohjA:54.4
3tvxB-5ohjA:13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
TYR A 159ASN A 321ILE A 336PHE A 340MET A 357GLN A 369PHE A 372
AKJ A 601 ( 4.7A)AKJ A 601 (-4.3A)AKJ A 601 (-3.8A)AKJ A 601 (-4.5A)AKJ A 601 (-3.4A)AKJ A 601 (-3.0A)AKJ A 601 (-4.1A)
0.33A
3tvxB-5wh6A:52.4
3tvxB-5wh6A:undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
TRP A 81PRO A 82LEU A 92LEU A 94ASN A 140ILE A 146MET A 149
NoneH1V A 501 (-4.6A)H1V A 501 (-4.2A)H1V A 501 (-4.7A)H1V A 501 (-3.2A)H1V A 501 (-3.8A)H1V A 501 ( 3.8A)
0.42A
3u5jA-6dneA:23.4
3u5jA-6dneA:undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
TRP A 81PRO A 82VAL A 87LEU A 92LEU A 94ASN A 140ILE A 146
NoneH1V A 501 (-4.6A)H1V A 501 ( 4.4A)H1V A 501 (-4.2A)H1V A 501 (-4.7A)H1V A 501 (-3.2A)H1V A 501 (-3.8A)
0.48A
3u5kB-6dneA:23.9
3u5kB-6dneA:undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 862GLY A 863TYR A 896ALA A 898SER A 904TYR A 907GLU A 988
BZC A 201 (-4.0A)BZC A 201 (-3.9A)BZC A 201 (-4.0A)BZC A 201 ( 3.9A)BZC A 201 (-3.3A)BZC A 201 (-3.6A)BZC A 201 (-4.0A)
0.58A
4hyfA-1efyA:19.9
4hyfA-1efyA:23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 384GLY A 385TYR A 414ALA A 416SER A 422TYR A 425GLU A 514
KU8 A 601 (-4.0A)KU8 A 601 (-3.5A)KU8 A 601 (-4.1A)KU8 A 601 ( 4.0A)KU8 A 601 (-2.9A)KU8 A 601 (-3.5A)KU8 A 601 (-3.9A)
0.71A
4hyfA-3c49A:19.5
4hyfA-3c49A:23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 201GLY A 202TYR A 235ALA A 237SER A 243TYR A 246GLU A 327
8E6 A 401 (-3.5A)8E6 A 401 (-3.9A)8E6 A 401 (-4.1A)8E6 A 401 (-3.5A)8E6 A 401 (-2.6A)8E6 A 401 (-3.4A)8E6 A 401 (-3.9A)
0.58A
4hyfA-5xstA:20.1
4hyfA-5xstA:undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
LYS A 327ASN A 381ARG A 383GLN A 385VAL A 386GLU A 387ARG A 458
None
0.70A
4mv7A-5cslA:43.7
4mv7A-5cslA:12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
LYS A 858ASN A 912ARG A 914GLN A 916VAL A 917GLU A 918ARG A 960
None
0.63A
4mv7A-5i8iA:55.7
4mv7A-5i8iA:13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
LYS A 236ASN A 288ARG A 290GLN A 292VAL A 293GLU A 294ARG A 341
None
0.80A
4mv7A-5vywA:54.8
4mv7A-5vywA:23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 61HIS A 85HIS A 259ASN A 260HIS A 263VAL A 283ALA A 286
CU A 400 (-3.2A) CU A 400 (-3.3A) CU A 401 (-3.2A)0TR A 410 (-4.1A)0TR A 410 ( 3.1A)0TR A 410 (-4.0A)0TR A 410 (-3.6A)
0.40A
4p6sA-2y9xA:21.2
4p6sA-2y9xA:26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 67HIS A 94HIS A 328ASN A 329HIS A 332VAL A 359ALA A 362
None
0.52A
4p6sA-3w6qA:19.0
4p6sA-3w6qA:18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 199HIS A 203HIS A 357ASN A 358HIS A 361VAL A 384ALA A 387
CUO A 708 (-3.3A)CUO A 708 (-3.5A)CUO A 708 (-3.3A)NoneCUO A 708 (-3.2A)NoneNone
0.68A
4p6sA-3wkyA:9.8
4p6sA-3wkyA:17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 223HIS A 227HIS A 379ASN A 380HIS A 383VAL A 406ALA A 409
CU A 801 (-3.0A) CU A 801 (-3.2A) CU A 802 (-3.2A)None CU A 802 (-3.2A)NoneNone
0.65A
4p6sA-4yzwA:8.9
4p6sA-4yzwA:17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
ALA A 126SER A 215GLY A 312ALA A 313GLU A 316THR A 317SER A 378
HEM A 601 (-3.8A)AER A 602 (-3.4A)AER A 602 ( 3.7A)HEM A 601 (-3.6A)NoneHEM A 601 ( 3.7A)AER A 602 (-3.2A)
0.58A
4r1zB-6b82A:52.1
4r1zB-6b82A:13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 61HIS A 85HIS A 259ASN A 260HIS A 263VAL A 283ALA A 286
CU A 400 (-3.2A) CU A 400 (-3.3A) CU A 401 (-3.2A)0TR A 410 (-4.1A)0TR A 410 ( 3.1A)0TR A 410 (-4.0A)0TR A 410 (-3.6A)
0.36A
5i3aA-2y9xA:21.4
5i3aA-2y9xA:26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 67HIS A 94HIS A 328ASN A 329HIS A 332VAL A 359ALA A 362
None
0.55A
5i3aA-3w6qA:18.9
5i3aA-3w6qA:18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 199HIS A 203HIS A 357ASN A 358HIS A 361VAL A 384ALA A 387
CUO A 708 (-3.3A)CUO A 708 (-3.5A)CUO A 708 (-3.3A)NoneCUO A 708 (-3.2A)NoneNone
0.69A
5i3aA-3wkyA:9.9
5i3aA-3wkyA:17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 223HIS A 227HIS A 379ASN A 380HIS A 383VAL A 406ALA A 409
CU A 801 (-3.0A) CU A 801 (-3.2A) CU A 802 (-3.2A)None CU A 802 (-3.2A)NoneNone
0.64A
5i3aA-4yzwA:8.8
5i3aA-4yzwA:17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 61HIS A 85HIS A 259ASN A 260HIS A 263VAL A 283ALA A 286
CU A 400 (-3.2A) CU A 400 (-3.3A) CU A 401 (-3.2A)0TR A 410 (-4.1A)0TR A 410 ( 3.1A)0TR A 410 (-4.0A)0TR A 410 (-3.6A)
0.31A
5i3aB-2y9xA:21.3
5i3aB-2y9xA:26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 67HIS A 94HIS A 328ASN A 329HIS A 332VAL A 359ALA A 362
None
0.55A
5i3aB-3w6qA:18.9
5i3aB-3w6qA:18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 199HIS A 203HIS A 357ASN A 358HIS A 361VAL A 384ALA A 387
CUO A 708 (-3.3A)CUO A 708 (-3.5A)CUO A 708 (-3.3A)NoneCUO A 708 (-3.2A)NoneNone
0.71A
5i3aB-3wkyA:9.9
5i3aB-3wkyA:17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 223HIS A 227HIS A 379ASN A 380HIS A 383VAL A 406ALA A 409
CU A 801 (-3.0A) CU A 801 (-3.2A) CU A 802 (-3.2A)None CU A 802 (-3.2A)NoneNone
0.65A
5i3aB-4yzwA:9.0
5i3aB-4yzwA:17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 61HIS A 85HIS A 259ASN A 260HIS A 263VAL A 283ALA A 286
CU A 400 (-3.2A) CU A 400 (-3.3A) CU A 401 (-3.2A)0TR A 410 (-4.1A)0TR A 410 ( 3.1A)0TR A 410 (-4.0A)0TR A 410 (-3.6A)
0.38A
5i3bA-2y9xA:21.3
5i3bA-2y9xA:26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 67HIS A 94HIS A 328ASN A 329HIS A 332VAL A 359ALA A 362
None
0.53A
5i3bA-3w6qA:18.3
5i3bA-3w6qA:18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 199HIS A 203HIS A 357ASN A 358HIS A 361VAL A 384ALA A 387
CUO A 708 (-3.3A)CUO A 708 (-3.5A)CUO A 708 (-3.3A)NoneCUO A 708 (-3.2A)NoneNone
0.70A
5i3bA-3wkyA:10.1
5i3bA-3wkyA:17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 223HIS A 227HIS A 379ASN A 380HIS A 383VAL A 406ALA A 409
CU A 801 (-3.0A) CU A 801 (-3.2A) CU A 802 (-3.2A)None CU A 802 (-3.2A)NoneNone
0.66A
5i3bA-4yzwA:9.1
5i3bA-4yzwA:17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
GLN A 71GLY A 88GLN A 105TYR A 118TRP A 125ASP A 163ASP A 175
MGR A 300 ( 4.1A)MGR A 300 ( 2.9A)MGR A 300 ( 3.0A)NoneMGR A 300 (-3.5A)MGR A 300 (-3.5A)MGR A 300 ( 4.3A)
0.54A
5vlmE-5vlgA:30.3
5vlmE-5vlgA:undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
GLY A 88TRP A 101GLN A 105TYR A 118TRP A 125ASP A 163TYR A 166
MGR A 300 ( 2.9A)MGR A 300 (-3.6A)MGR A 300 ( 3.0A)NoneMGR A 300 (-3.5A)MGR A 300 (-3.5A)MGR A 300 (-3.0A)
0.32A
5vlmG-5vlgA:29.4
5vlmG-5vlgA:undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
VAL A 54VAL A 67LYS A 69PHE A 152MET A 202ILE A 213ASP A 214
GNP A 401 (-4.2A)GNP A 401 (-4.8A)GNP A 401 (-3.3A)NoneGNP A 401 (-3.6A)GNP A 401 (-4.6A)GNP A 401 ( 2.7A)
0.64A
5yf9B-4jr7A:44.7
5yf9B-4jr7A:11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
VAL A 53VAL A 66LYS A 68PHE A 113MET A 163ILE A 174ASP A 175
NoneHC4 A 401 (-4.4A)HC4 A 401 (-2.7A)HC4 A 401 (-3.4A)HC4 A 401 ( 4.0A)HC4 A 401 ( 3.7A)HC4 A 401 (-4.0A)
0.68A
5yf9B-5movA:34.8
5yf9B-5movA:25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
VAL A 54VAL A 67LYS A 69ILE A 134PHE A 152ILE A 213ASP A 214
GNP A 401 (-4.2A)GNP A 401 (-4.8A)GNP A 401 (-3.3A)NoneNoneGNP A 401 (-4.6A)GNP A 401 ( 2.7A)
0.31A
5ywmX-4jr7A:44.5
5ywmX-4jr7A:11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
VAL A 53VAL A 66LYS A 68ILE A 95PHE A 113ILE A 174ASP A 175
NoneHC4 A 401 (-4.4A)HC4 A 401 (-2.7A)HC4 A 401 ( 4.5A)HC4 A 401 (-3.4A)HC4 A 401 ( 3.7A)HC4 A 401 (-4.0A)
0.33A
5ywmX-5movA:47.3
5ywmX-5movA:25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
GLY B 299GLY B 300TRP B 342GLY B 431PRO B 432GLY B 474GLY B 475
None
0.50A
6ag0A-1bplB:36.1
6ag0A-1bplB:20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
GLY A 299GLY A 300TRP A 342GLY A 431PRO A 432GLY A 474GLY A 475
None
0.43A
6ag0A-1vjsA:55.5
6ag0A-1vjsA:6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
LYS A 68GLY A 106TRP A 136ASP A 162TRP A 163MET A 197TYR A 198
None
0.45A
6ag0A-1e43A:59.0
6ag0A-1e43A:11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
LYS A 72GLY A 110TRP A 140ASP A 166TRP A 167MET A 202TYR A 203
GLC A 601 (-3.0A)GLC A 602 ( 3.2A)GLC A 602 ( 3.7A)GLC A 603 (-2.8A)GLC A 602 ( 4.8A)GLC A 605 ( 3.5A)GLC A 603 (-4.0A)
0.33A
6ag0A-2d3lA:59.6
6ag0A-2d3lA:9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
LYS A 68GLY A 106TRP A 136ASP A 162TRP A 163MET A 197TYR A 198
None
0.49A
6ag0C-1e43A:59.0
6ag0C-1e43A:11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
LYS A 72GLY A 110TRP A 140ASP A 166TRP A 167MET A 202TYR A 203
GLC A 601 (-3.0A)GLC A 602 ( 3.2A)GLC A 602 ( 3.7A)GLC A 603 (-2.8A)GLC A 602 ( 4.8A)GLC A 605 ( 3.5A)GLC A 603 (-4.0A)
0.36A
6ag0C-2d3lA:59.6
6ag0C-2d3lA:9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 45ASN A 47ARG A 49ASN A 58TRP A 65GLU A 68ARG A 70
GAL A 998 (-3.8A)GAL A 998 (-4.1A)BGC A 999 ( 2.7A)GAL A 998 (-3.6A)GAL A 998 (-3.7A)BGC A 999 ( 2.8A)BGC A 999 (-4.3A)
0.50A
6b8kA-1hlcA:19.8
6b8kA-1hlcA:26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 435ASN A 437ARG A 439ASN A 451TRP A 459GLU A 462ARG A 464
None
0.55A
6b8kA-2wsuA:22.5
6b8kA-2wsuA:13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 235ASN A 237ARG A 239ASN A 248TRP A 255GLU A 258ARG A 260
GAL A 501 (-3.9A)GAL A 501 (-3.8A)NAG A 502 ( 2.7A)GAL A 501 (-3.8A)GAL A 501 (-3.6A)NAG A 502 ( 2.7A)NAG A 502 (-4.0A)
0.24A
6b8kA-3nv3A:24.6
6b8kA-3nv3A:26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 60ASN A 62ARG A 64ASN A 73TRP A 80GLU A 83ARG A 85
GAL A 201 (-3.8A)GAL A 201 (-3.9A)FUC A 202 (-2.7A)GAL A 201 (-3.8A)GAL A 201 ( 3.8A)FUC A 202 (-2.7A)FUC A 202 ( 4.1A)
0.32A
6b8kA-3vv1A:21.6
6b8kA-3vv1A:19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 61ASN A 63ARG A 65ASN A 75TRP A 82GLU A 85ARG A 87
GAL A 402 (-3.9A)GAL A 402 (-3.9A)BGC A 403 (-2.7A)GAL A 402 (-4.0A)GAL A 402 (-3.7A)BGC A 403 (-2.9A)BGC A 403 (-4.1A)
0.37A
6b8kA-3wv6A:23.7
6b8kA-3wv6A:15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 235ASN A 237ARG A 239ASN A 248TRP A 255GLU A 258ARG A 260
GAL A 404 (-4.0A)GAL A 404 (-4.1A)GLC A 405 (-2.7A)GAL A 404 (-3.7A)GAL A 404 ( 3.7A)GLC A 405 ( 2.8A)GLC A 405 (-4.3A)
0.24A
6b8kA-3wv6A:23.7
6b8kA-3wv6A:15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 49ASN A 51ARG A 53ASN A 62TRP A 69GLU A 72ARG A 74
PGZ A 1 (-3.9A)PGZ A 1 (-3.8A)PGZ A 1 (-3.6A)PGZ A 1 (-3.8A)PGZ A 1 (-4.0A)PGZ A 1 (-3.5A)None
0.62A
6b8kA-3zxeA:23.1
6b8kA-3zxeA:25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 229ASN A 231ARG A 233ASN A 242TRP A 249GLU A 252ARG A 254
None
0.43A
6b8kA-4fqzA:22.1
6b8kA-4fqzA:17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 49ASN A 51ARG A 53ASN A 62TRP A 69GLU A 72ARG A 74
GAL A 201 (-3.9A)GAL A 201 (-4.1A)6S2 A 202 (-2.9A)GAL A 201 (-3.7A)GAL A 201 (-3.5A)6S2 A 202 (-2.8A)6S2 A 202 (-3.5A)
0.61A
6b8kA-4y26A:22.5
6b8kA-4y26A:25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
HIS A 57ASN A 59ARG A 61ASN A 70TRP A 77GLU A 80ARG A 82
PEG A 201 (-3.7A)PEG A 201 ( 4.8A)PEG A 201 (-3.0A)PEG A 201 (-3.6A)PEG A 201 (-2.8A)PEG A 201 (-3.3A)None
0.28A
6b8kA-5jp5A:24.4
6b8kA-5jp5A:30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
