Results

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	RMSD	Seq. Identity (%)	HETATM
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1q2w	3C-LIKE PROTEASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.72A	18.89	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	1q2w	3C-LIKE PROTEASE (SARSr-CoV)	5 / 10	LEU B 86 VAL B 20 TYR B 37 GLY B 29 LEU B 87	1.66A	19.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	1q2w	3C-LIKE PROTEASE (SARSr-CoV)	5 / 9	LEU B 86 VAL B 20 TYR B 37 GLY B 29 LEU B 87	1.70A	19.07	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	1uj1	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.65A	19.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	1uj1	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.59A	19.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	1uj1	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 11	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.63A	19.06 20.58	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	1uk2	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU B 86 VAL B 148 GLY B 146 LEU B 177 TYR B 37	1.66A	19.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	1wof	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU B 86 VAL B 20 TYR B 37 GLY B 29 LEU B 87	1.65A	19.35	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	1wof	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU B 86 VAL B 20 TYR B 37 GLY B 29 LEU B 87	1.62A	19.34	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	1z1j	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU B1030 VAL B1091 VAL B1020 LEU B1032 TYR B1037	1.64A	19.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	2a5k	3C-LIKE PEPTIDASE (SARSr-CoV)	5 / 9	LEU B 86 VAL B 148 GLY B 146 LEU B 177 TYR B 37	1.70A	18.99	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	2a5k	3C-LIKE PEPTIDASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.65A	19.16	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	2a5k	3C-LIKE PEPTIDASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.67A	19.17	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	2acf	REPLICASE POLYPROTEIN 1AB (SARS-COV Tor2)	5 / 10	LEU B 291 ASN B 297 VAL B 277 GLY B 261 TYR B 295	1.50A	16.17	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	2acf	REPLICASE POLYPROTEIN 1AB (SARS-COV Tor2)	5 / 11	LEU B 291 VAL B 277 VAL B 259 GLY B 261 TYR B 295	1.73A	15.51 17.70	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2acf	REPLICASE POLYPROTEIN 1AB (SARS-COV Tor2)	5 / 10	LEU B 291 VAL B 277 VAL B 259 GLY B 261 TYR B 295	1.64A	15.36	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	2acf	REPLICASE POLYPROTEIN 1AB (SARS-COV Tor2)	5 / 10	LEU C 291 LYS C 292 VAL C 277 GLY C 261 TYR C 295	1.36A	15.82	None GOL C1006 (-2.8A) None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	2acf	REPLICASE POLYPROTEIN 1AB (SARS-COV Tor2)	5 / 9	LEU C 291 LYS C 292 VAL C 277 GLY C 260 TYR C 295	1.45A	15.36	None GOL C1006 (-2.8A) None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2acf	REPLICASE POLYPROTEIN 1AB (SARS-COV Tor2)	5 / 10	LEU B 291 VAL B 277 VAL B 259 GLY B 261 TYR B 295	1.70A	15.36	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	2ajf	ACE2 (Homo sapiens)	5 / 10	LEU B 240 VAL B 604 TYR B 237 GLY B 605 LEU B 595	1.51A	21.90	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	2alv	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.70A	19.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	2alv	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 9	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.71A	19.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	2amd	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 11	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.69A	19.31 20.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2amq	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 30 VAL A 91 VAL A 20 LEU A 32 TYR A 37	1.67A	19.31	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	2amq	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 30 VAL A 91 VAL A 20 LEU A 32 TYR A 37	1.64A	20.04	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	2amq	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.69A	19.17	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	2dd8	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU S 355 VAL S 328 TYR S 352 GLY S 326 LEU S 421	1.67A	16.04	None None None NAG S1330 (-3.0A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	2dd8	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU S 355 VAL S 328 TYR S 352 GLY S 326 LEU S 421	1.64A	16.39	None None None NAG S1330 (-3.0A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	2dd8	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 9	LEU S 355 VAL S 328 TYR S 352 GLY S 326 LEU S 421	1.65A	16.04	None None None NAG S1330 (-3.0A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	2fav	REPLICASE POLYPROTEIN 1AB (PP1AB) (ORF1AB) (SARSr-CoV)	5 / 10	LEU B 110 VAL B 96 VAL B 78 GLY B 80 TYR B 114	1.71A	15.37	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2fav	REPLICASE POLYPROTEIN 1AB (PP1AB) (ORF1AB) (SARSr-CoV)	5 / 10	LEU B 110 VAL B 96 VAL B 78 GLY B 80 TYR B 114	1.63A	15.05	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	2fav	REPLICASE POLYPROTEIN 1AB (PP1AB) (ORF1AB) (SARSr-CoV)	5 / 10	LEU A 110 ASN A 116 VAL A 96 GLY A 80 TYR A 114	1.48A	15.71	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	2fav	REPLICASE POLYPROTEIN 1AB (PP1AB) (ORF1AB) (SARSr-CoV)	5 / 11	LEU A 110 VAL A 96 VAL A 78 GLY A 80 TYR A 114	1.72A	15.00 17.40	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2fav	REPLICASE POLYPROTEIN 1AB (PP1AB) (ORF1AB) (SARSr-CoV)	5 / 10	LEU B 110 VAL B 96 VAL B 78 GLY B 80 TYR B 114	1.68A	15.05	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	2fe8	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 11	LEU C 200 VAL C 206 TYR C 208 LEU C 186 GLU C 204	1.40A	19.04 20.04	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	2fe8	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 10	LEU C 235 TYR C 214 TYR C 208 GLY C 220 LEU C 186	1.70A	19.74	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2ghw	ANTI-SCFV ANTIBODY, 80R (Homo sapiens)	5 / 10	LEU D 45 VAL D 217 TYR D 168 GLY D 233 TRP D 107	1.65A	16.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	2ghw	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 11	VAL C 369 CYH C 366 TYR C 367 GLY C 368 LEU C 412	1.76A	16.88 17.50	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	2ghw	ANTI-SCFV ANTIBODY, 80R (Homo sapiens)	5 / 11	LEU D 45 VAL D 217 TYR D 168 GLY D 233 TRP D 107	1.68A	16.85 19.23	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2ghw	ANTI-SCFV ANTIBODY, 80R (Homo sapiens)	5 / 10	LEU D 45 VAL D 217 TYR D 168 GLY D 233 TRP D 107	1.70A	16.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	2h85	PUTATIVE ORF1AB POLYPROTEIN (SARSr-CoV)	5 / 10	LEU A 189 VAL A 141 VAL A 182 GLY A 140 TYR A 324	1.64A	20.51	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2h85	PUTATIVE ORF1AB POLYPROTEIN (SARSr-CoV)	5 / 10	LEU A 189 VAL A 141 VAL A 182 GLY A 140 TYR A 324	1.66A	20.11	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	2hsx	LEADER PROTEIN P65 HOMOLOG NSP1 (SARSr-CoV)	5 / 11	VAL A 97 VAL A 9 GLY A 41 LEU A 53 GLU A 44	1.62A	11.72 12.56	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	2op9	REPLICASE POLYPROTEIN 1AB (PP1AB, ORF1AB) 3C-LIKE PROTEINASE (3CL-PRO, 3CLP) (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.65A	18.26	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	2op9	REPLICASE POLYPROTEIN 1AB (PP1AB, ORF1AB) 3C-LIKE PROTEINASE (3CL-PRO, 3CLP) (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.65A	18.37	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2op9	REPLICASE POLYPROTEIN 1AB (PP1AB, ORF1AB) 3C-LIKE PROTEINASE (3CL-PRO, 3CLP) (SARSr-CoV)	5 / 10	LEU B 30 VAL B 91 VAL B 20 LEU B 32 TYR B 37	1.72A	18.26	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2op9	REPLICASE POLYPROTEIN 1AB (PP1AB, ORF1AB) 3C-LIKE PROTEINASE (3CL-PRO, 3CLP) (SARSr-CoV)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.73A	18.26	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	2op9	REPLICASE POLYPROTEIN 1AB (PP1AB, ORF1AB) 3C-LIKE PROTEINASE (3CL-PRO, 3CLP) (SARSr-CoV)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.63A	18.26	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	2ozk	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	5 / 11	LEU A 189 VAL A 141 VAL A 182 GLY A 140 TYR A 324	1.55A	21.34 23.01	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2ozk	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	5 / 10	LEU B 189 VAL B 141 VAL B 182 GLY B 140 TYR B 324	1.64A	20.65	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	2ozk	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	5 / 10	LEU A 189 VAL A 141 VAL A 182 GLY A 140 TYR A 324	1.63A	20.55	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	2pwx	3C-LIKE PROTEINASE (SARS-COV BJ01)	5 / 11	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.62A	19.13 20.66	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	2pwx	3C-LIKE PROTEINASE (SARS-COV BJ01)	5 / 9	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.68A	18.99	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2pwx	3C-LIKE PROTEINASE (SARS-COV BJ01)	5 / 10	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.64A	19.13	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2pwx	3C-LIKE PROTEINASE (SARS-COV BJ01)	5 / 10	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.58A	19.13	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2pwx	3C-LIKE PROTEINASE (SARS-COV BJ01)	5 / 10	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.64A	19.13	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	2q6g	REPLICASE POLYPROTEIN 1AB (SARS-COV BJ01)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.62A	20.51	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2q6g	REPLICASE POLYPROTEIN 1AB (SARS-COV BJ01)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.72A	19.50	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2q6g	REPLICASE POLYPROTEIN 1AB (SARS-COV BJ01)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.72A	19.50	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2q6g	REPLICASE POLYPROTEIN 1AB (SARS-COV BJ01)	5 / 10	LEU A 30 VAL A 91 VAL A 20 LEU A 32 TYR A 37	1.70A	19.50	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	2q6g	REPLICASE POLYPROTEIN 1AB (SARS-COV BJ01)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.64A	20.51	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	2q6g	REPLICASE POLYPROTEIN 1AB (SARS-COV BJ01)	5 / 10	LEU A 30 VAL A 91 VAL A 20 LEU A 32 TYR A 37	1.67A	20.51	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	2q6g	REPLICASE POLYPROTEIN 1AB (SARS-COV BJ01)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.66A	19.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	2qc2	3C-LIKE PROTEINASE (-)	5 / 9	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.70A	19.04	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	2qc2	3C-LIKE PROTEINASE (-)	5 / 11	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.67A	19.18 20.66	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	2qc2	3C-LIKE PROTEINASE (-)	5 / 10	LEU B 86 VAL B 20 TYR B 37 GLY B 29 LEU B 87	1.59A	19.16	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	2qc2	3C-LIKE PROTEINASE (-)	5 / 9	LEU B 86 VAL B 20 TYR B 37 GLY B 29 LEU B 87	1.60A	19.17	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2qc2	3C-LIKE PROTEINASE (-)	5 / 10	LEU B 86 VAL B 20 TYR B 37 GLY B 29 LEU B 87	1.67A	19.18	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2qcy	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.63A	19.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	2qcy	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.66A	19.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2qcy	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.63A	19.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	2qcy	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 11	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.60A	19.24 20.58	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2qcy	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.56A	19.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	2qiq	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.68A	18.09	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	2qiq	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.71A	18.09	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	2rhb	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	5 / 10	LEU B 189 VAL B 141 VAL B 182 GLY B 140 TYR B 324	1.68A	20.14	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	2rhb	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	5 / 10	LEU B 189 VAL B 141 VAL B 182 GLY B 140 TYR B 324	1.63A	20.14	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	2rhb	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	5 / 11	LEU F 299 VAL F 236 GLY F 253 LEU F 227 GLU F 210	1.67A	20.95 22.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	2vj1	MAIN PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.71A	18.54	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	2w2g	NSP3 (SARSr-CoV)	5 / 10	LEU A 475 VAL A 448 VAL A 445 GLY A 446 LEU A 412	1.65A	20.25	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2w2g	NSP3 (SARSr-CoV)	5 / 10	LEU A 475 VAL A 448 VAL A 445 GLY A 446 LEU A 412	1.37A	18.90	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	2w2g	NSP3 (SARSr-CoV)	5 / 11	LEU A 475 VAL A 448 VAL A 445 GLY A 446 LEU A 412	1.48A	20.25 20.00	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	2w2g	NSP3 (SARSr-CoV)	5 / 11	LEU A 475 VAL A 448 VAL A 445 GLY A 446 LEU A 412	1.47A	18.90 20.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2w2g	NSP3 (SARSr-CoV)	5 / 10	LEU A 475 VAL A 448 VAL A 445 GLY A 446 LEU A 412	1.42A	18.90	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	2w2g	NSP3 (SARSr-CoV)	5 / 10	LEU A 475 VAL A 448 VAL A 445 GLY A 446 LEU A 412	1.62A	19.66	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	2w2g	NSP3 (SARSr-CoV)	5 / 10	LEU A 475 VAL A 448 VAL A 445 GLY A 446 LEU A 412	1.55A	20.25	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	2wct	NSP3 (SARSr-CoV)	5 / 10	LEU A 475 LYS A 477 VAL A 448 GLY A 446 LEU A 412	1.43A	18.90	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	2wct	NSP3 (SARSr-CoV)	5 / 9	LEU C 475 LYS C 476 VAL C 448 GLY C 446 LEU C 412	1.52A	18.90	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	2xyv	NSP10 (SARSr-CoV)	5 / 9	LEU B 31 LYS B 28 VAL B 108 GLY B 109 TYR B 30	1.62A	12.55	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	3atw	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.65A	19.93	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	3atw	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.63A	19.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	3bgf	SPIKE PROTEIN S1 (SARSr-CoV)	5 / 10	LEU A 374 VAL A 369 GLY A 418 LEU A 355 TYR A 352	1.70A	16.15	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	3bgf	SPIKE PROTEIN S1 (SARSr-CoV)	5 / 10	LEU A 374 VAL A 369 GLY A 418 LEU A 355 TYR A 352	1.72A	16.67	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	3bgf	SPIKE PROTEIN S1 (SARSr-CoV)	5 / 11	LEU A 374 VAL A 369 GLY A 418 LEU A 355 TYR A 352	1.76A	16.61 17.95	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3bgf	SPIKE PROTEIN S1 (SARSr-CoV)	5 / 10	LEU A 374 VAL A 369 GLY A 418 LEU A 355 TYR A 352	1.74A	16.21	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	3d0g	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 11	LEU F 421 VAL F 354 TYR F 356 TYR F 352 LEU F 499	1.73A	14.03 17.40	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	3d0g	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 10	LEU B 222 ASN B 397 TYR B 516 GLY B 399 TYR B 217	1.41A	21.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3d0h	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 10	LEU B 240 VAL B 604 TYR B 243 GLY B 605 TYR B 237	1.66A	21.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3d0h	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 10	LEU B 240 VAL B 604 TYR B 243 GLY B 605 TYR B 237	1.65A	21.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3d0h	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 10	LEU B 240 VAL B 604 TYR B 243 GLY B 605 TYR B 237	1.67A	21.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	3d0h	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 11	LEU B 116 VAL B 185 TYR B 199 TYR B 183 LEU B 120	1.66A	21.85 21.11	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	3d0h	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 10	LEU B 240 VAL B 604 TYR B 243 GLY B 605 TYR B 237	1.59A	21.75	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	3d62	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.70A	18.09	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	3e91	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.69A	18.51	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3e91	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU B 86 VAL B 148 GLY B 146 LEU B 177 TYR B 37	1.68A	18.51	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3e91	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU B 86 VAL B 148 GLY B 146 LEU B 177 TYR B 37	1.62A	18.51	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	3e91	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.68A	19.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	3e91	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 11	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.65A	18.51 20.58	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	3e91	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.65A	18.35	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	3e9s	NSP3 (SARSr-CoV)	5 / 11	LEU A 200 VAL A 206 TYR A 208 LEU A 186 GLU A 204	1.36A	19.18 19.65	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	3ea7	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 30 VAL A 91 VAL A 20 LEU A 32 TYR A 37	1.63A	18.53	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	3eaj	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.69A	18.35	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	3eaj	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU B 86 VAL B 148 GLY B 146 LEU B 177 TYR B 37	1.71A	18.51	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	3eaj	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.71A	19.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	3f9e	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.69A	18.44	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	3f9g	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.72A	18.37	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	3f9g	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 11	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.68A	18.44 21.22	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	3f9h	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU B 86 VAL B 20 TYR B 37 GLY B 29 LEU B 87	1.68A	18.99	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	3f9h	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU B 86 VAL B 148 GLY B 146 LEU B 177 TYR B 37	1.71A	18.99	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	3f9h	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU B 86 VAL B 20 TYR B 37 GLY B 29 LEU B 87	1.66A	19.16	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	3i6k	HLA, A-2 MEMBRANE GLYCOPROTEIN PEPTIDE (Homo sapiens; SARS-COV TJF)	5 / 11	LEU C 1 VAL A 34 GLY A 26 TYR A 99 GLU A 63	1.57A	1.51 2.46	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	3iwm	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU B 30 VAL B 91 VAL B 20 LEU B 32 TYR B 37	1.63A	19.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	3iwm	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU D 86 VAL D 20 TYR D 37 GLY D 29 LEU D 87	1.54A	19.23	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	3iwm	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU D 86 VAL D 20 TYR D 37 GLY D 29 LEU D 87	1.55A	19.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3m3s	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 30 VAL A 91 VAL A 20 LEU A 32 TYR A 37	1.66A	19.11	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	3m3s	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 30 VAL A 91 VAL A 20 LEU A 32 TYR A 37	1.63A	19.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	3m3s	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.69A	19.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3m3s	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 30 VAL A 91 VAL A 20 LEU A 32 TYR A 37	1.74A	19.11	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	3m3s	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.66A	19.23	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3m3t	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.65A	19.31	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	3m3t	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.69A	19.17	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3m3t	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.59A	19.31	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	3m3t	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 11	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.63A	19.31 20.66	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3m3t	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.66A	19.31	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	3m3v	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.71A	19.35	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	3m3v	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU B 177 VAL B 157 VAL B 104 TYR B 101 LEU B 30	1.72A	19.58	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	3m3v	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.67A	18.28	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	3m3v	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU B 86 VAL B 148 GLY B 146 LEU B 177 TYR B 37	1.70A	18.44	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	3mj5	REPLICASE POLYPROTEIN 1A (SARSr-CoV)	5 / 10	LEU B 235 VAL B 221 TYR B 214 GLY B 220 LEU B 186	1.67A	19.71	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	3sci	ACE2 (Homo sapiens)	5 / 10	LEU B 116 VAL B 185 TYR B 199 TYR B 183 LEU B 120	1.70A	22.00	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	3scj	ACE2 (Homo sapiens)	5 / 10	LEU B 222 ASN B 397 TYR B 516 GLY B 399 TYR B 217	1.44A	22.00	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	3sck	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 10	LEU A 240 VAL A 604 TYR A 237 GLY A 605 LEU A 595	1.50A	21.70	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	3scl	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 10	LEU B 240 VAL B 604 TYR B 243 GLY B 605 TYR B 237	1.53A	21.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3scl	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 10	LEU B 240 VAL B 604 TYR B 243 GLY B 605 TYR B 237	1.59A	21.93	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3scl	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 10	LEU B 240 VAL B 604 TYR B 243 GLY B 605 TYR B 237	1.62A	21.93	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	3scl	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 11	LEU B 240 VAL B 604 TYR B 243 GLY B 605 TYR B 237	1.62A	21.93 21.11	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3scl	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 10	LEU B 240 VAL B 604 TYR B 243 GLY B 605 TYR B 237	1.61A	21.93	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	3sna	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 11	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.70A	18.36 20.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3sna	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.66A	18.36	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	3sna	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.70A	18.32	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	3sna	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.73A	18.32	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3sna	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.72A	18.36	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	3sna	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.72A	18.36	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	3snd	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 11	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.80A	18.32 20.97	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	3snd	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 148 GLY A 146 LEU A 177 TYR A 37	1.71A	19.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	3szn	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.63A	19.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	4hi3	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU B 86 VAL B 20 TYR B 37 GLY B 29 LEU B 87	1.71A	19.23	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	4hi3	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU B 86 VAL B 20 TYR B 37 GLY B 29 LEU B 87	1.68A	18.15	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	4mds	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.72A	19.00	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	4mds	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.70A	18.99	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	4rna	PAPAIN-LIKE PROTEASE (Human betacoronavirus 2c EMC/2012)	5 / 11	LEU A 60 VAL A 75 TYR A 72 LEU A 80 GLU A 64	1.69A	21.34 20.37	PO4 A 405 (-4.0A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	4wy3	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.69A	19.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5b6o	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.71A	19.16	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	5b6o	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.61A	19.14	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	5b6o	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.64A	19.15	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	5b6o	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 9	LEU A 86 VAL A 20 TYR A 37 GLY A 29 LEU A 87	1.64A	17.48	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5c5o	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU B 30 VAL B 91 VAL B 20 LEU B 32 TYR B 37	1.72A	19.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5e6j	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 10	LEU A 217 VAL A 221 TYR A 234 GLY A 220 TYR A 214	1.60A	19.35	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5e6j	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 10	LEU A 217 VAL A 221 TYR A 234 GLY A 220 TYR A 214	1.69A	19.35	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	5e6j	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 10	LEU A 217 VAL A 221 TYR A 234 GLY A 220 TYR A 214	1.64A	19.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	5e6j	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 11	LEU D 200 VAL D 206 TYR D 208 LEU D 186 GLU D 204	1.41A	19.35 21.24	5MW E 48 ( 3.9A) None None None 5MW E 48 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	5e6j	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 10	LEU A 217 VAL A 221 TYR A 234 GLY A 220 TYR A 214	1.64A	19.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5e6j	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 10	LEU A 217 VAL A 221 TYR A 234 GLY A 220 TYR A 214	1.64A	19.35	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	5e6j	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 11	LEU A 217 VAL A 221 TYR A 234 GLY A 220 TYR A 214	1.68A	19.29 21.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	5e6j	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 10	LEU A 217 VAL A 221 TYR A 234 GLY A 220 TYR A 214	1.64A	21.69	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	5e6j	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 9	LEU A 217 VAL A 221 TYR A 234 GLY A 220 TYR A 214	1.66A	21.69	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	5rfc	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.74A	14.55	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	5rfc	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.77A	14.55	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	5rfc	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 9	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.77A	13.56	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	5tl6	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 10	LEU B 235 TYR B 214 TYR B 208 GLY B 220 LEU B 186	1.70A	19.89	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	5tl6	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 11	LEU D 200 VAL D 206 TYR D 208 LEU D 186 GLU D 204	1.40A	19.56 21.54	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	5x58	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	5 / 11	VAL B 369 CYH B 366 TYR B 367 GLY B 368 LEU B 412	1.69A	18.90 16.19	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5x58	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	5 / 10	VAL C 581 VAL C 601 TYR C 598 GLY C 579 LEU C 597	1.69A	18.97	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	5x58	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	5 / 11	VAL C 581 VAL C 601 TYR C 598 GLY C 579 LEU C 597	1.70A	18.97 16.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5x58	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	5 / 10	VAL C 581 VAL C 601 TYR C 598 GLY C 579 LEU C 597	1.69A	18.97	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5x58	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	5 / 10	VAL C 581 VAL C 601 TYR C 598 GLY C 579 LEU C 597	1.68A	18.97	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5x59	S PROTEIN (MERS-CoV)	5 / 10	LEU B 873 VAL B1124 VAL B1127 TYR B1135 LEU B1005	1.74A	16.51	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	5x5b	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	5 / 9	LEU B 355 VAL B 328 TYR B 352 GLY B 326 LEU B 421	1.69A	19.47	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	5x5f	S PROTEIN (MERS-CoV)	5 / 10	LEU C 608 TYR C 609 GLY C 610 LEU C 638 TYR C 606	1.69A	16.83	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5x5f	S PROTEIN (MERS-CoV)	5 / 10	VAL C 625 VAL A 329 TYR A 64 GLY A 331 TYR C 641	1.67A	16.51	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	5xlr	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU C 58 TYR C 41 TYR C 42 GLY C 39 LEU C 264	1.41A	18.56	LEU C 58 ( 0.6A) TYR C 41 ( 1.3A) TYR C 42 ( 1.3A) GLY C 39 ( 0.0A) LEU C 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	5xlr	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 9	LEU C 58 TYR C 197 TYR C 42 GLY C 39 LEU C 264	1.64A	18.64	LEU C 58 ( 0.6A) TYR C 197 ( 1.3A) TYR C 42 ( 1.3A) GLY C 39 ( 0.0A) LEU C 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	5xlr	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 11	LEU A 58 VAL A 40 VAL A 186 TYR A 42 LEU A 264	1.66A	18.44 15.82	LEU A 58 ( 0.6A) VAL A 40 ( 0.6A) VAL A 186 ( 0.6A) TYR A 42 ( 1.3A) LEU A 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	5xlr	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU C 355 VAL C 328 TYR C 352 GLY C 326 LEU C 421	1.69A	18.52	LEU C 355 ( 0.5A) VAL C 328 ( 0.6A) TYR C 352 ( 1.3A) GLY C 326 ( 0.0A) LEU C 421 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	5xlr	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 11	LEU C 58 VAL C 40 VAL C 186 TYR C 42 LEU C 264	1.67A	18.70 16.01	LEU C 58 ( 0.6A) VAL C 40 ( 0.6A) VAL C 186 ( 0.6A) TYR C 42 ( 1.3A) LEU C 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	5xlr	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 9	LEU C 355 VAL C 328 TYR C 352 GLY C 326 LEU C 421	1.68A	18.52	LEU C 355 ( 0.5A) VAL C 328 ( 0.6A) TYR C 352 ( 1.3A) GLY C 326 ( 0.0A) LEU C 421 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5xlr	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU A 58 TYR A 197 TYR A 42 GLY A 39 LEU A 264	1.54A	18.70	LEU A 58 ( 0.6A) TYR A 197 ( 1.3A) TYR A 42 ( 1.3A) GLY A 39 ( 0.0A) LEU A 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	5xlr	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU C 58 TYR C 197 TYR C 42 GLY C 39 LEU C 264	1.68A	18.56	LEU C 58 ( 0.6A) TYR C 197 ( 1.3A) TYR C 42 ( 1.3A) GLY C 39 ( 0.0A) LEU C 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5xlr	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU C 58 TYR C 41 TYR C 42 GLY C 39 LEU C 264	1.64A	18.70	LEU C 58 ( 0.6A) TYR C 41 ( 1.3A) TYR C 42 ( 1.3A) GLY C 39 ( 0.0A) LEU C 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5xlr	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU A 58 VAL A 40 VAL A 186 TYR A 42 LEU A 264	1.72A	18.70	LEU A 58 ( 0.6A) VAL A 40 ( 0.6A) VAL A 186 ( 0.6A) TYR A 42 ( 1.3A) LEU A 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6acc	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU B 52 VAL C 555 TYR B 266 TYR B 53 LEU B 54	1.65A	18.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	6acc	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU A 52 VAL B 555 TYR A 266 TYR A 53 LEU A 54	1.67A	18.61	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6acc	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU B 52 VAL C 555 TYR B 266 TYR B 53 LEU B 54	1.68A	18.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6acc	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 11	LEU B 52 VAL C 555 TYR B 266 TYR B 53 LEU B 54	1.70A	18.78 16.09	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6acc	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU A 52 VAL B 555 TYR A 266 TYR A 53 LEU A 54	1.68A	18.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6acc	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU A 374 ASN A 375 GLY A 512 LEU A 355 TYR A 356	1.68A	18.64	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6acc	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU A 52 VAL B 555 TYR A 266 TYR A 53 LEU A 54	1.64A	18.64	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6acj	ACE2 (Homo sapiens)	5 / 10	LEU D 240 VAL D 604 TYR D 243 GLY D 605 TYR D 237	1.52A	22.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6acj	ACE2 (Homo sapiens)	5 / 10	LEU D 240 VAL D 604 TYR D 243 GLY D 605 TYR D 237	1.56A	22.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6acj	ACE2 (Homo sapiens)	5 / 11	LEU D 240 VAL D 604 TYR D 243 GLY D 605 TYR D 237	1.55A	22.24 20.83	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6acj	ACE2 (Homo sapiens)	5 / 10	LEU D 240 VAL D 604 TYR D 243 GLY D 605 TYR D 237	1.54A	22.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6acj	ACE2 (Homo sapiens)	5 / 10	LEU D 240 VAL D 604 TYR D 243 GLY D 605 TYR D 237	1.46A	22.15	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6crw	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 9	LEU B 421 VAL B 328 VAL B 354 TYR B 352 GLY B 326	1.50A	19.10	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6crw	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 10	LEU B 421 VAL B 328 VAL B 354 TYR B 352 GLY B 326	1.59A	19.08	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6crw	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 10	LEU B 421 VAL B 328 VAL B 354 TYR B 352 GLY B 326	1.59A	19.25	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6crw	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 11	LEU B 421 VAL B 328 VAL B 354 TYR B 352 GLY B 326	1.56A	19.25 16.67	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	6crw	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 10	LEU B 421 VAL B 328 VAL B 354 TYR B 352 GLY B 326	1.53A	19.10	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6crw	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 10	LEU B 421 VAL B 328 VAL B 354 TYR B 352 GLY B 326	1.58A	19.25	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	6crx	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 9	LEU B 421 VAL B 328 TYR B 352 GLY B 326 LEU B 499	1.67A	18.71	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6crx	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 10	LEU B 421 VAL B 328 VAL B 354 GLY B 326 LEU B 499	1.53A	19.25	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6cs1	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 11	VAL B 40 VAL B 186 TYR B 42 GLY B 39 LEU B 264	1.74A	19.14 16.56	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6cs1	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 10	ASN C 304 VAL C 581 TYR C 598 GLY C 580 LEU C 615	1.45A	19.08	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6iex	MHC CLASS I ANTIGEN (Homo sapiens; SARSr-CoV)	5 / 10	LEU A 95 TYR A 118 TYR A 123 LEU C 10 TYR A 74	1.75A	19.93	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	6iex	MHC CLASS I ANTIGEN (Homo sapiens; SARSr-CoV)	5 / 9	LEU A 95 TYR A 118 TYR A 123 LEU C 10 TYR A 74	1.66A	19.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6jyt	HELICASE (SARSr-CoV)	5 / 10	LEU B 165 VAL B 210 TYR B 198 TYR B 211 LEU B 163	1.74A	20.84	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6jyt	HELICASE (SARSr-CoV)	5 / 11	LEU A 581 VAL A 456 CYH A 556 LEU A 585 GLU A 551	1.74A	20.96 19.94	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6lze	VIRAL PROTEASE (SARS-CoV-2)	5 / 11	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.77A	19.02	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6lze	VIRAL PROTEASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.68A	19.53	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6lze	VIRAL PROTEASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.80A	19.02	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6lze	VIRAL PROTEASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.76A	19.53	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6m0j	ACE2 (Homo sapiens)	5 / 11	LEU A 539 GLY A 537 LEU A 410 TYR A 587 GLU A 527	1.70A	21.94 20.39	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m0k	VIRAL PROTEASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.74A	19.49	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6m0k	VIRAL PROTEASE (SARS-CoV-2)	5 / 9	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.75A	18.90	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m0k	VIRAL PROTEASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.72A	19.49	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m18	ACE2 (Homo sapiens)	5 / 10	LEU B 116 VAL B 185 TYR B 199 TYR B 183 LEU B 120	1.67A	20.92	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m18	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT1 (Homo sapiens)	5 / 10	ASN C 435 VAL C 125 TYR C 128 GLY C 126 LEU C 52	1.65A	19.68	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6m18	ACE2 SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT1 (Homo sapiens)	5 / 11	LEU D 624 GLY D 629 LEU D 717 TYR D 633 GLU C 352	1.76A	20.89 18.93	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6m18	ACE2 (Homo sapiens)	5 / 10	LEU B 116 VAL B 185 TYR B 199 TYR B 183 LEU B 120	1.66A	20.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6m18	ACE2 (Homo sapiens)	5 / 10	LEU B 116 VAL B 185 TYR B 199 TYR B 183 LEU B 120	1.75A	20.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6m18	ACE2 (Homo sapiens)	5 / 10	LEU B 116 VAL B 185 TYR B 199 TYR B 183 LEU B 120	1.65A	20.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6m1d	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT1 (Homo sapiens)	5 / 11	VAL A 79 VAL A 304 TYR A 87 TRP A 534 GLU A 300	1.29A	20.68 19.34	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m1d	ACE2 (Homo sapiens)	5 / 10	VAL B 209 VAL B 212 TYR B 215 TYR B 217 GLY B 211	1.41A	20.80	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6m1d	ACE2 (Homo sapiens)	5 / 11	VAL D 209 VAL D 212 TYR D 217 GLY D 211 GLU D 571	1.30A	20.60 18.10	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6m1d	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT1 (Homo sapiens)	5 / 11	VAL A 324 TYR A 322 GLY A 326 LEU A 398 GLU A 391	1.73A	20.50 18.51	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m2n	3CL PROTEASE (SARS-CoV-2)	5 / 10	LEU D 177 VAL D 157 VAL D 104 TYR D 101 LEU D 30	1.79A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m2n	3CL PROTEASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.76A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m2n	3CL PROTEASE (SARS-CoV-2)	5 / 10	LEU B 177 VAL B 157 VAL B 104 TYR B 101 LEU B 30	1.77A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6m2n	3CL PROTEASE (SARS-CoV-2)	5 / 9	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.78A	18.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6m2n	3CL PROTEASE (SARS-CoV-2)	5 / 9	LEU B 177 VAL B 157 VAL B 104 TYR B 101 LEU B 30	1.79A	18.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m2n	3CL PROTEASE (SARS-CoV-2)	5 / 10	LEU D 177 VAL D 86 TYR D 161 GLY D 179 LEU D 30	1.75A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6m2n	3CL PROTEASE (SARS-CoV-2)	5 / 10	LEU C 177 VAL C 86 TYR C 161 GLY C 179 LEU C 30	1.78A	18.69	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m2n	3CL PROTEASE (SARS-CoV-2)	5 / 10	LEU C 177 VAL C 86 TYR C 161 GLY C 179 LEU C 30	1.71A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6m2n	3CL PROTEASE (SARS-CoV-2)	5 / 10	LEU C 30 VAL C 91 VAL C 20 LEU C 32 TYR C 37	1.71A	18.69	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m2n	3CL PROTEASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.78A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6m2q	3CL PROTEASE (SARS-CoV-2)	5 / 9	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.78A	18.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6m2q	3CL PROTEASE (SARS-CoV-2)	5 / 11	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.78A	18.69	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m2q	3CL PROTEASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.77A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m2q	3CL PROTEASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.69A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m71	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.77A	20.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6m71	NSP12 (SARS-CoV-2)	5 / 9	VAL A 233 TYR A 238 TYR A 237 LEU A 240 TYR A 732	1.71A	20.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m71	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.73A	20.17	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	6m71	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.79A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m71	NSP12 (SARS-CoV-2)	5 / 10	LEU A 749 VAL A 704 VAL A 475 TYR A 479 TYR A 748	1.74A	20.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m71	NSP12 (SARS-CoV-2)	5 / 10	LEU A 131 VAL A 182 TYR A 175 GLY A 179 LEU A 127	1.68A	20.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	6m71	NSP12 (SARS-CoV-2)	5 / 10	VAL A 233 TYR A 238 TYR A 237 LEU A 240 TYR A 732	1.70A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6m71	NSP12 (SARS-CoV-2)	5 / 10	VAL A 233 TYR A 238 TYR A 237 LEU A 240 TYR A 732	1.64A	20.17	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6m71	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.79A	20.17	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6nb6	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	ASN A 889 VAL A 893 TYR A1029 GLY A 892 LEU A1031	1.70A	17.67	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6nb8	S230 ANTIGEN-BINDING (FAB) FRAGMENT, HEAVY CHAIN (Homo sapiens)	5 / 10	LEU H 81 VAL H 123 TYR H 94 GLY H 8 LEU H 79	1.55A	17.94	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6nur	NSP12 (SARSr-CoV)	5 / 9	LEU A 127 VAL A 182 TYR A 175 GLY A 179 LEU A 146	1.70A	20.15	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6nus	NSP12 (SARSr-CoV)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.71A	20.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6nus	NSP12 (SARSr-CoV)	5 / 11	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.73A	20.27 18.35	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6nus	NSP12 (SARSr-CoV)	5 / 11	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.64A	20.25 18.35	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6nus	NSP12 (SARSr-CoV)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.70A	20.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6nus	NSP12 (SARSr-CoV)	5 / 10	ASN A 790 VAL A 792 VAL A 785 TYR A 788 TYR A 787	1.68A	20.68	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6nus	NSP12 (SARSr-CoV)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.72A	20.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6nus	NSP12 (SARSr-CoV)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.63A	20.68	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6vsb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 10	VAL C 62 VAL C 90 TYR C 266 GLY C 268 LEU C 216	1.74A	17.70	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6vsb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 11	VAL C 62 TYR C 266 GLY C 268 LEU C 216 GLU C 191	1.70A	17.70 16.55	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6vsb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 11	VAL C 62 VAL C 90 TYR C 266 GLY C 268 LEU C 216	1.72A	18.42 16.89	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6vsb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 10	VAL C 62 VAL C 90 TYR C 266 GLY C 268 LEU C 216	1.72A	18.66	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6vw1	ACE2 (Homo sapiens)	5 / 9	LEU B 116 VAL B 185 TYR B 199 TYR B 183 LEU B 120	1.65A	22.02	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6vw1	ACE2 (Homo sapiens)	5 / 10	LEU B 116 VAL B 185 TYR B 199 TYR B 183 LEU B 120	1.65A	22.15	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6vw1	ACE2 (Homo sapiens)	5 / 10	LEU B 116 VAL B 185 TYR B 199 TYR B 183 LEU B 120	1.58A	22.15	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6vw1	ACE2 (Homo sapiens)	5 / 11	LEU B 116 VAL B 185 TYR B 199 TYR B 183 LEU B 120	1.52A	22.15 20.83	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6vw1	ACE2 (Homo sapiens)	5 / 10	LEU B 116 VAL B 185 TYR B 199 TYR B 183 LEU B 120	1.55A	22.15	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	6vw1	ACE2 (Homo sapiens)	5 / 10	LEU B 116 VAL B 185 TYR B 199 TYR B 183 LEU B 120	1.61A	22.17	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6vw1	ACE2 (Homo sapiens)	5 / 10	LEU B 116 VAL B 185 TYR B 199 TYR B 183 LEU B 120	1.58A	22.05	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6vxs	NSP3 (SARS-CoV-2)	5 / 11	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6vxs	NSP3 (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.79A		None None None SO4 A 201 ( 4.8A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.73A		None None None SO4 A 201 ( 4.8A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 78 TYR A 113	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	6vxs	NSP3 (SARS-CoV-2)	5 / 9	LEU B 109 LYS B 110 VAL B 95 GLY B 78 TYR B 113	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 78 TYR B 113	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.75A		None None None SO4 A 201 ( 4.8A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.65A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6vxs	NSP3 (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.75A		None None None SO4 A 201 ( 4.8A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 78 TYR A 113	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6vxs	NSP3 (SARS-CoV-2)	5 / 11	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.66A		None None None SO4 A 201 ( 4.8A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6vxx	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 10	VAL A 62 VAL A 90 TYR A 266 GLY A 268 LEU A 216	1.73A	17.65	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6vyb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 10	VAL A 62 VAL A 90 TYR A 266 GLY A 268 LEU A 216	1.62A	17.57	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6vyb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 11	VAL A 62 VAL A 90 TYR A 266 GLY A 268 LEU A 216	1.74A	17.71 16.36	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6vyb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 10	VAL A 62 VAL A 90 TYR A 266 GLY A 268 LEU A 216	1.68A	18.10	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6vyb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 10	VAL A 62 VAL A 90 TYR A 266 GLY A 268 LEU A 216	1.63A	17.57	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6vyb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 11	VAL A 62 VAL A 90 TYR A 266 GLY A 268 LEU A 216	1.63A	17.57 16.43	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6vyb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 10	VAL A 62 VAL A 90 TYR A 266 GLY A 268 LEU A 216	1.63A	17.57	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w01	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.60A	21.08	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6w01	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 9	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.59A	21.61	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w01	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.54A	21.08	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6w01	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.61A	21.72	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	6w01	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.64A	21.48	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	6w01	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 9	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.54A	20.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6w01	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.54A	21.58	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w01	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.49A	21.08	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6w01	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 11	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.54A	21.08 22.75	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6w01	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 11	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.51A	21.48 23.18	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6w02	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 ASN A 115 VAL A 95 GLY A 79 TYR A 113	1.51A	17.36	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	6w02	NSP3 (SARS-CoV-2)	5 / 9	LEU B 109 LYS B 110 VAL B 95 GLY B 79 TYR B 113	1.48A	17.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w02	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.63A	17.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w02	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.68A	17.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6w02	NSP3 (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.72A	17.06 18.10	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6w02	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.71A	17.15	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6w37	PROTEIN 7A (SARS-CoV-2)	5 / 10	LEU A 41 ASN A 28 TYR A 60 GLY A 27 LEU A 62	1.67A	8.89	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w41	CR3022 FAB HEAVY CHAIN CR3022 FAB LIGHT CHAIN (Homo sapiens)	5 / 10	LEU H 45 VAL L 85 TYR L 36 GLY L 101 TRP H 103	1.73A	13.33	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	6w41	CR3022 FAB HEAVY CHAIN CR3022 FAB LIGHT CHAIN (Homo sapiens)	5 / 10	LEU H 45 VAL L 85 TYR L 36 GLY L 101 TRP H 103	1.77A	14.98	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w41	CR3022 FAB HEAVY CHAIN CR3022 FAB LIGHT CHAIN (Homo sapiens)	5 / 10	LEU H 45 VAL L 85 TYR L 36 GLY L 101 TRP H 103	1.73A	13.33	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w41	CR3022 FAB HEAVY CHAIN CR3022 FAB LIGHT CHAIN (Homo sapiens)	5 / 10	LEU H 45 VAL L 85 TYR L 36 GLY L 101 TRP H 103	1.66A	13.33	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6w41	CR3022 FAB HEAVY CHAIN (Homo sapiens)	5 / 11	TYR H 90 GLY H 106 TRP H 82 LEU H 80 GLU H 10	1.72A	14.98 14.79	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6w41	CR3022 FAB HEAVY CHAIN (Homo sapiens)	5 / 11	TYR H 90 GLY H 106 TRP H 82 LEU H 80 GLU H 10	1.64A	13.33 17.44	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6w41	CR3022 FAB HEAVY CHAIN CR3022 FAB LIGHT CHAIN (Homo sapiens)	5 / 11	LEU H 45 VAL L 85 TYR L 36 GLY L 101 TRP H 103	1.68A	13.33 17.44	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6w4h	NSP16 (SARS-CoV-2)	5 / 11	VAL A6965 TYR A7009 GLY A7006 LEU A6981 GLU A7015	1.51A	18.57 20.75	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6w63	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.69A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.67A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.74A	15.02 17.05	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.79A	14.65 17.23	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.64A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.76A	15.02 17.05	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.77A	14.65 17.23	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w75	NSP10 (SARS-CoV-2)	5 / 10	LEU B4328 VAL D4274 TYR B4283 LEU B4365 TYR B4329	1.66A	12.77	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6w75	NSP10 (SARS-CoV-2)	5 / 11	LEU B4328 VAL D4274 TYR B4283 LEU B4365 TYR B4329	1.72A	12.77 15.40	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6w75	NSP10 (SARS-CoV-2)	5 / 9	LEU D4328 VAL B4274 TYR D4283 LEU D4365 TYR D4329	1.73A	13.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6w75	NSP10 (SARS-CoV-2)	5 / 9	LEU B4328 VAL D4274 TYR B4283 LEU B4365 TYR B4329	1.69A	13.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w75	NSP10 (SARS-CoV-2)	5 / 10	LEU D4328 VAL B4274 TYR D4283 LEU D4365 TYR D4329	1.72A	12.77	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	6w75	NSP10 (SARS-CoV-2)	5 / 10	LEU B4328 VAL D4274 TYR B4283 LEU B4365 TYR B4329	1.78A	13.67	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6w75	NSP10 (SARS-CoV-2)	5 / 11	LEU D4328 VAL B4274 TYR D4283 LEU D4365 TYR D4329	1.78A	12.77 15.40	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6w75	NSP16 (SARS-CoV-2)	5 / 11	VAL C6965 TYR C7009 GLY C7006 LEU C6981 GLU C7015	1.42A	14.00 15.49	None NA C7103 ( 4.8A) None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	LEU B 113 TYR B 95 GLY B 287 TRP B 93 TYR B 112	1.79A		None None CL B 502 (-3.6A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	5 / 11	LEU C 113 TYR C 95 GLY C 287 TRP C 93 TYR C 112	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	LEU C 113 TYR C 95 GLY C 287 TRP C 93 TYR C 112	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	5 / 11	LEU B 113 TYR B 95 GLY B 287 TRP B 93 TYR B 112	1.76A		None None CL B 502 (-3.6A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	LEU B 113 TYR B 95 GLY B 287 TRP B 93 TYR B 112	1.80A	20.92	None None CL B 502 (-3.6A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	5 / 11	LEU A 199 VAL A 205 TYR A 207 LEU A 185 GLU A 203	1.38A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	LEU B 113 TYR B 95 GLY B 287 TRP B 93 TYR B 112	1.75A		None None CL B 502 (-3.6A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wcf	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.67A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wcf	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.62A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6wcf	NSP3 (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wcf	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 ASN A 115 VAL A 95 GLY A 79 TYR A 113	1.44A	16.05	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wcf	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6wcf	NSP3 (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wcf	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 78 TYR A 113	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wcf	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 LYS A 110 VAL A 95 GLY A 79 TYR A 113	1.76A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wen	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.65A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6wen	NSP3 (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6wen	NSP3 (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wen	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 ASN A 115 VAL A 95 GLY A 79 TYR A 113	1.50A	16.05	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wen	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.73A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wen	NSP3 (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6wey	NSP3 (SARS-CoV-2)	5 / 11	LEU A 313 VAL A 299 VAL A 281 GLY A 283 TYR A 317	1.80A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wey	NSP3 (SARS-CoV-2)	5 / 10	LEU A 313 VAL A 299 VAL A 281 GLY A 283 TYR A 317	1.73A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wey	NSP3 (SARS-CoV-2)	5 / 10	LEU A 357 ASN A 219 VAL A 351 VAL A 348 TYR A 317	1.74A	16.03	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6wey	NSP3 (SARS-CoV-2)	5 / 11	LEU A 313 VAL A 299 VAL A 281 GLY A 283 TYR A 317	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wey	NSP3 (SARS-CoV-2)	5 / 10	LEU A 313 VAL A 299 VAL A 281 GLY A 283 TYR A 317	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wey	NSP3 (SARS-CoV-2)	5 / 10	LEU A 313 VAL A 299 VAL A 281 GLY A 283 TYR A 317	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6wjt	NSP10 (SARS-CoV-2)	5 / 11	LEU B4328 VAL D4274 TYR B4283 LEU B4365 TYR B4329	1.69A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	6wjt	NSP10 (SARS-CoV-2)	5 / 10	LEU B4328 VAL D4274 TYR B4283 LEU B4365 TYR B4329	1.75A	13.67	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wjt	NSP10 (SARS-CoV-2)	5 / 10	LEU B4328 VAL D4274 TYR B4283 LEU B4365 TYR B4329	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wjt	NSP10 (SARS-CoV-2)	5 / 10	LEU B4328 VAL D4274 TYR B4283 LEU B4365 TYR B4329	1.63A	12.77	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 11	VAL C6965 TYR C7009 GLY C7006 LEU C6981 GLU C7015	1.42A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6wjt	NSP10 (SARS-CoV-2)	5 / 9	LEU D4328 VAL B4274 TYR D4283 LEU D4365 TYR D4329	1.71A	13.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6wjt	NSP10 (SARS-CoV-2)	5 / 9	LEU B4328 VAL D4274 TYR B4283 LEU B4365 TYR B4329	1.66A	13.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wjt	NSP10 (SARS-CoV-2)	5 / 10	LEU B4328 VAL D4274 TYR B4283 LEU B4365 TYR B4329	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	6wjt	NSP10 (SARS-CoV-2)	5 / 10	LEU D4328 VAL B4274 TYR D4283 LEU D4365 TYR D4329	1.80A	13.67	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wjt	NSP10 (SARS-CoV-2)	5 / 10	LEU D4328 VAL B4274 TYR D4283 LEU D4365 TYR D4329	1.70A	12.77	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6wkq	NSP10 (SARS-CoV-2)	5 / 9	LEU D4328 VAL B4274 TYR D4283 LEU D4365 TYR D4329	1.73A	13.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wkq	NSP10 (SARS-CoV-2)	5 / 10	LEU D4328 VAL B4274 TYR D4283 LEU D4365 TYR D4329	1.73A	12.77	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6wkq	NSP10 (SARS-CoV-2)	5 / 11	LEU D4328 VAL B4274 TYR D4283 LEU D4365 TYR D4329	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wkq	NSP10 (SARS-CoV-2)	5 / 10	LEU B4328 VAL D4274 TYR B4283 LEU B4365 TYR B4329	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6wkq	NSP16 (SARS-CoV-2)	5 / 11	VAL C6965 TYR C7009 GLY C7006 LEU C6981 GLU C7015	1.42A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	6wkq	NSP10 (SARS-CoV-2)	5 / 10	LEU B4328 VAL D4274 TYR B4283 LEU B4365 TYR B4329	1.78A	13.67	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6wkq	NSP10 (SARS-CoV-2)	5 / 9	LEU B4328 VAL D4274 TYR B4283 LEU B4365 TYR B4329	1.68A	13.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wkq	NSP10 (SARS-CoV-2)	5 / 10	LEU B4328 VAL D4274 TYR B4283 LEU B4365 TYR B4329	1.65A	12.77	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6wkq	NSP10 (SARS-CoV-2)	5 / 11	LEU B4328 VAL D4274 TYR B4283 LEU B4365 TYR B4329	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.65A	21.49	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU B 190 VAL B 142 VAL B 183 GLY B 141 TYR B 325	1.67A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU B 190 VAL B 142 VAL B 183 GLY B 141 TYR B 325	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.60A	21.70	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 183 VAL A 187 TYR A 180 LEU A 76	1.56A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 11	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.54A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.49A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 11	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.51A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU B 190 VAL B 142 TYR B 180 GLY B 141 TYR B 325	1.54A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 142 VAL A 183 GLY A 141 TYR A 325	1.66A	21.70	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 11	LEU B 190 VAL B 142 TYR B 180 GLY B 141 TYR B 325	1.56A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU B 190 VAL B 142 TYR B 180 GLY B 141 TYR B 325	1.59A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU B 190 VAL B 142 TYR B 180 GLY B 141 TYR B 325	1.66A	21.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.54A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 183 VAL A 187 TYR A 180 LEU A 76	1.64A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU B 190 VAL B 142 TYR B 180 GLY B 141 TYR B 325	1.59A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU B 190 VAL B 183 VAL B 187 TYR B 180 LEU B 76	1.69A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU B 190 VAL B 142 TYR B 180 GLY B 141 TYR B 325	1.65A	21.70	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 11	LEU B 190 VAL B 142 TYR B 180 GLY B 141 TYR B 325	1.60A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.54A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 9	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.55A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.62A	21.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU B 190 VAL B 142 VAL B 183 GLY B 141 TYR B 325	1.70A	21.70	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU B 190 VAL B 183 VAL B 187 TYR B 180 LEU B 76	1.61A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 9	LEU B 190 VAL B 142 TYR B 180 GLY B 141 TYR B 325	1.65A	21.49	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 9	LEU B 190 VAL B 142 TYR B 180 GLY B 141 TYR B 325	1.60A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 9	LEU A 190 VAL A 142 TYR A 180 GLY A 141 TYR A 325	1.59A	21.49	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 11	LEU A 190 VAL A 183 VAL A 187 TYR A 180 LEU A 76	1.66A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU A 190 VAL A 183 VAL A 187 TYR A 180 LEU A 76	1.77A	21.49	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 11	LEU B 190 VAL B 142 VAL B 183 GLY B 141 TYR B 325	1.58A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	LEU B 190 VAL B 142 TYR B 180 GLY B 141 TYR B 325	1.70A	21.49	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wnp	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6wnp	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wnp	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.78A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 78 TYR B 113	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 78 TYR B 113	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.73A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.65A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	LEU D 109 VAL D 95 VAL D 77 GLY D 79 TYR D 113	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.67A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.60A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.61A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	LEU D 109 VAL D 95 VAL D 77 GLY D 79 TYR D 113	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU D 109 VAL D 95 VAL D 77 GLY D 79 TYR D 113	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU D 109 VAL D 95 VAL D 77 GLY D 79 TYR D 113	1.62A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.64A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU B 109 ASN B 115 VAL B 95 GLY B 79 TYR B 113	1.46A	15.98	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU D 109 VAL D 95 VAL D 77 GLY D 79 TYR D 113	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6wq3	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 11	VAL A6965 TYR A7009 GLY A7006 LEU A6981 GLU A7015	1.51A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wqf	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.73A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wqf	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.76A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6wqf	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 9	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.77A	18.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6wrh	PEPTIDASE C16 (SARS-CoV-2)	5 / 10	LEU A 234 VAL A 220 TYR A 213 GLY A 219 LEU A 185	1.78A	20.80	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6y2f	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.69A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6yb7	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.77A	13.31	None None None DMS A 407 (-3.8A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6yb7	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.77A	13.31	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6yla	LIGHT CHAIN SPIKE GLYCOPROTEIN (Homo sapiens; SARS-CoV-2)	5 / 10	LEU A 517 VAL A 382 TYR C 55 GLY A 381 LEU A 390	1.49A		None DMS A 905 (-4.3A) DMS A 905 (-4.3A) None DMS A 905 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6yla	LIGHT CHAIN SPIKE GLYCOPROTEIN (Homo sapiens; SARS-CoV-2)	5 / 10	LEU A 517 VAL A 382 TYR C 55 GLY A 381 LEU A 390	1.40A		None DMS A 905 (-4.3A) DMS A 905 (-4.3A) None DMS A 905 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6yla	HEAVY CHAIN (Homo sapiens)	5 / 11	TYR H 94 GLY H 112 TRP H 83 LEU H 81 GLU H 10	1.64A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	6yla	LIGHT CHAIN SPIKE GLYCOPROTEIN (Homo sapiens; SARS-CoV-2)	5 / 10	LEU A 517 VAL A 382 TYR C 55 GLY A 381 LEU A 390	1.60A	16.94	None DMS A 905 (-4.3A) DMS A 905 (-4.3A) None DMS A 905 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 10	LEU H 45 VAL L 91 TYR L 42 GLY L 107 TRP H 109	1.79A		None 1PE L1603 ( 4.8A) None 1PE L1603 (-4.3A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 11	LEU L 52 VAL H 108 GLY H 98 TYR L 42 GLU L 61	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 11	LEU C 52 TYR C 55 TYR C 97 GLY B 99 GLU C 61	1.70A		None DMS A 905 (-4.3A) None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6yla	HEAVY CHAIN (Homo sapiens)	5 / 11	TYR B 94 GLY B 112 TRP B 83 LEU B 81 GLU B 10	1.69A		None MLI B 304 ( 4.8A) None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6yla	HEAVY CHAIN (Homo sapiens)	5 / 11	TYR B 94 GLY B 112 TRP B 83 LEU B 81 GLU B 10	1.67A		None MLI B 304 ( 4.8A) None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 11	LEU C 52 VAL B 108 GLY B 98 TYR C 42 GLU C 61	1.66A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6yla	LIGHT CHAIN SPIKE GLYCOPROTEIN (Homo sapiens; SARS-CoV-2)	5 / 11	LEU A 517 VAL A 382 TYR C 55 GLY A 381 LEU A 390	1.48A		None DMS A 905 (-4.3A) DMS A 905 (-4.3A) None DMS A 905 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6yla	HEAVY CHAIN (Homo sapiens)	5 / 11	TYR H 94 GLY H 112 TRP H 83 LEU H 81 GLU H 10	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 11	LEU L 52 TYR L 55 TYR L 97 GLY H 99 GLU L 61	1.70A		None DMS L1601 (-4.2A) None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6yla	LIGHT CHAIN SPIKE GLYCOPROTEIN (Homo sapiens; SARS-CoV-2)	5 / 9	LEU A 517 VAL A 382 TYR C 55 GLY A 381 LEU A 390	1.57A	16.94	None DMS A 905 (-4.3A) DMS A 905 (-4.3A) None DMS A 905 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6ym0	HEAVY CHAIN (Homo sapiens)	5 / 11	TYR H 94 GLY H 112 TRP H 83 LEU H 81 GLU H 10	1.62A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6ym0	HEAVY CHAIN (Homo sapiens)	5 / 11	TYR H 94 GLY H 112 TRP H 83 LEU H 81 GLU H 10	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6ym0	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 11	LEU L 52 TYR L 55 TYR L 97 GLY H 99 GLU L 61	1.64A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ynq	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.76A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	6ynq	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 9	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.78A	18.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ynq	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.75A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	5 / 11	LEU C 52 TYR C 55 TYR C 97 GLY B 99 GLU C 61	1.69A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6yor	IGG H CHAIN (Homo sapiens)	5 / 11	TYR H 94 GLY H 112 TRP H 83 LEU H 81 GLU H 10	1.73A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6yor	IGG H CHAIN (Homo sapiens)	5 / 11	TYR B 94 GLY B 112 TRP B 83 LEU B 81 GLU B 10	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6yor	IGG H CHAIN (Homo sapiens)	5 / 11	TYR B 94 GLY B 112 TRP B 83 LEU B 81 GLU B 10	1.64A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	5 / 10	LEU H 45 VAL L 91 TYR L 42 GLY L 107 TRP H 109	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	5 / 11	LEU C 52 VAL B 108 GLY B 98 TYR C 42 GLU C 61	1.69A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	5 / 11	LEU L 52 TYR L 55 TYR L 97 GLY H 99 GLU L 61	1.69A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	5 / 11	LEU L 52 VAL H 108 GLY H 98 TYR L 42 GLU L 61	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6yor	IGG H CHAIN (Homo sapiens)	5 / 11	TYR H 94 GLY H 112 TRP H 83 LEU H 81 GLU H 10	1.63A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	5 / 10	LEU B 45 VAL C 91 TYR C 42 GLY C 107 TRP B 109	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6yt8	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.67A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU D 109 VAL D 95 VAL D 77 GLY D 79 TYR D 113	1.80A		EDO D 204 ( 4.5A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU D 109 VAL D 95 VAL D 77 GLY D 79 TYR D 113	1.77A		EDO D 204 ( 4.5A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 9	LEU E 109 LYS E 110 VAL E 95 GLY E 78 TYR E 113	1.61A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU E 109 VAL E 95 VAL E 77 GLY E 79 TYR E 113	1.73A		None None None EPE E 203 (-3.3A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU E 109 VAL E 95 VAL E 77 GLY E 79 TYR E 113	1.73A		None None None EPE E 203 (-3.3A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU D 109 VAL D 95 VAL D 77 GLY D 79 TYR D 113	1.75A		EDO D 204 ( 4.5A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU D 109 VAL D 95 VAL D 77 GLY D 79 TYR D 113	1.72A		EDO D 204 ( 4.5A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU E 109 VAL E 95 VAL E 77 GLY E 79 TYR E 113	1.64A		None None None EPE E 203 (-3.3A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.68A		None None None EPE C 202 (-3.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.74A		None None None EPE C 202 (-3.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU D 109 VAL D 95 VAL D 77 GLY D 79 TYR D 113	1.67A		EDO D 204 ( 4.5A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.77A		None None None EPE C 202 (-3.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.76A		None None None EPE C 202 (-3.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU E 109 VAL E 95 VAL E 77 GLY E 79 TYR E 113	1.70A		None None None EPE E 203 (-3.3A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU E 109 VAL E 95 VAL E 77 GLY E 79 TYR E 113	1.77A		None None None EPE E 203 (-3.3A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.69A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU E 109 ASN E 115 VAL E 95 GLY E 79 TYR E 113	1.54A	15.92	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU E 109 VAL E 95 VAL E 77 GLY E 79 TYR E 113	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU D 109 VAL D 95 VAL D 77 GLY D 79 TYR D 113	1.75A		None None None EDO D 203 (-3.1A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU E 109 VAL E 95 VAL E 77 GLY E 79 TYR E 113	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU D 109 VAL D 95 VAL D 77 GLY D 79 TYR D 113	1.72A		None None None EDO D 203 (-3.1A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU E 109 VAL E 95 VAL E 77 GLY E 79 TYR E 113	1.67A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.73A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU D 109 VAL D 95 VAL D 77 GLY D 79 TYR D 113	1.79A		None None None EDO D 203 (-3.1A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.76A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.76A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.76A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 9	LEU E 109 LYS E 110 VAL E 95 GLY E 78 TYR E 113	1.57A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU D 109 VAL D 95 VAL D 77 GLY D 79 TYR D 113	1.66A		None None None EDO D 203 (-3.1A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU A 109 ASN A 115 VAL A 95 GLY A 79 TYR A 113	1.53A	15.92	None EDO A 207 (-3.9A) None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU E 109 VAL E 95 VAL E 77 GLY E 79 TYR E 113	1.73A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU E 109 VAL E 95 VAL E 77 GLY E 79 TYR E 113	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.73A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU B 109 ASN B 115 VAL B 95 GLY B 79 TYR B 113	1.54A	15.92	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.80A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU D 109 VAL D 95 VAL D 77 GLY D 79 TYR D 113	1.75A		None None None EDO D 203 (-3.1A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.71A		None None None EDO A 204 (-3.6A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.67A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.73A		None None None EDO A 204 (-3.6A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.76A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.65A		None None None EDO A 204 (-3.6A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	LEU C 109 VAL C 95 VAL C 77 GLY C 79 TYR C 113	1.66A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.74A		None None None EDO A 204 (-3.6A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU B 109 VAL B 95 VAL B 77 GLY B 79 TYR B 113	1.80A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	LEU A 109 VAL A 95 VAL A 77 GLY A 79 TYR A 113	1.78A		None None None EDO A 204 (-3.6A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7bqy	MAIN PROTEASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.80A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	7bqy	MAIN PROTEASE (SARS-CoV-2; synthetic construct)	5 / 11	VAL A 42 VAL A 86 CYH A 85 TYR A 54 LEU C 4	1.74A		None None None None PJE C 5 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7bqy	MAIN PROTEASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	7btf	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7btf	NSP12 (SARS-CoV-2)	5 / 10	VAL A 233 TYR A 238 TYR A 237 LEU A 240 TYR A 732	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	7btf	NSP12 (SARS-CoV-2)	5 / 9	LEU A 127 VAL A 182 TYR A 175 GLY A 179 LEU A 146	1.78A	20.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	7btf	NSP12 (SARS-CoV-2)	5 / 10	VAL A 233 TYR A 238 TYR A 237 LEU A 240 TYR A 732	1.74A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	7btf	NSP12 (SARS-CoV-2)	5 / 9	VAL A 233 TYR A 238 TYR A 237 LEU A 240 TYR A 732	1.77A	20.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	7btf	NSP12 (SARS-CoV-2)	5 / 11	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7btf	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.77A	20.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	7btf	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.79A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7btf	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7buy	VIRUS MAIN PROTEASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 86 TYR A 161 GLY A 179 LEU A 30	1.73A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7buy	VIRUS MAIN PROTEASE (SARS-CoV-2)	5 / 10	LEU A 177 VAL A 157 VAL A 104 TYR A 101 LEU A 30	1.76A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	7bv1	NSP12 (SARS-CoV-2)	5 / 9	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.77A	19.71	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.71A	20.08	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	VAL A 233 TYR A 238 TYR A 237 LEU A 240 TYR A 732	1.75A	19.61	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	LEU A 127 VAL A 182 TYR A 175 GLY A 179 LEU A 146	1.79A	20.08	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	LEU A 127 VAL A 182 TYR A 175 GLY A 179 LEU A 146	1.76A	19.61	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.75A	19.61	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	7bv1	NSP12 (SARS-CoV-2)	5 / 9	LEU A 127 VAL A 182 TYR A 175 GLY A 179 LEU A 146	1.73A	19.71	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	LEU A 127 VAL A 182 TYR A 175 GLY A 179 LEU A 146	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	LEU A 131 VAL A 182 TYR A 175 GLY A 179 LEU A 127	1.70A	20.08	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.75A	20.56	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	7bv1	NSP12 (SARS-CoV-2)	5 / 9	VAL A 233 TYR A 238 TYR A 237 LEU A 240 TYR A 732	1.78A	19.71	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	LEU A 127 VAL A 182 TYR A 175 GLY A 179 LEU A 146	1.78A	20.56	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	VAL A 233 TYR A 238 TYR A 237 LEU A 240 TYR A 732	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	LEU A 127 VAL A 182 TYR A 175 GLY A 179 LEU A 146	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	LEU A 127 VAL A 182 TYR A 175 GLY A 179 LEU A 146	1.80A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	7bv1	NSP12 (SARS-CoV-2)	5 / 11	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	7bv1	NSP12 (SARS-CoV-2)	5 / 11	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.76A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	7bv1	NSP12 (SARS-CoV-2)	5 / 11	LEU A 127 VAL A 182 TYR A 175 GLY A 179 LEU A 146	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	7bv2	NSP12 (SARS-CoV-2)	5 / 11	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	7bv2	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	7bv2	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.77A	20.56	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	7bv2	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.78A	19.61	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	7bv2	NSP12 (SARS-CoV-2)	5 / 9	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.79A	19.71	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	7bv2	NSP12 (SARS-CoV-2)	5 / 10	LEU A 127 VAL A 182 TYR A 175 GLY A 179 LEU A 146	1.80A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	7bv2	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.76A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSH_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT REVERSE TRANSCRIPTASE P51 SUBUNIT)	7bv2	NSP12 (SARS-CoV-2)	5 / 11	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	7bv2	NSP12 (SARS-CoV-2)	5 / 9	VAL A 233 TYR A 238 TYR A 237 LEU A 240 TYR A 732	1.72A	19.71	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7bv2	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.69A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7bv2	NSP12 (SARS-CoV-2)	5 / 10	LEU A 131 VAL A 182 TYR A 175 GLY A 179 LEU A 127	1.80A	20.08	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7bv2	NSP12 (SARS-CoV-2)	5 / 10	LEU A 247 VAL A 182 GLY A 179 LEU A 172 TYR A 175	1.72A	20.08	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKW_A_EFZA2000_1 (POL POLYPROTEIN)	7bv2	NSP12 (SARS-CoV-2)	5 / 10	LEU A 127 VAL A 182 TYR A 175 GLY A 179 LEU A 146	1.79A	19.61	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	7bv2	NSP12 (SARS-CoV-2)	5 / 9	LEU A 127 VAL A 182 TYR A 175 GLY A 179 LEU A 146	1.75A	19.71	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	7bv2	NSP12 (SARS-CoV-2)	5 / 10	LEU A 127 VAL A 182 TYR A 175 GLY A 179 LEU A 146	1.80A	20.08	None