Ligand ID: EFZ


Drugbank ID:
DB00625
(Efavirenz)


Indication:
For use in combination treatment of HIV infection (AIDS)

Get human targets for EFZ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'EFZ' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.72A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 10
LEU B  86
VAL B  20
TYR B  37
GLY B  29
LEU B  87
1.66A19.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 9
LEU B  86
VAL B  20
TYR B  37
GLY B  29
LEU B  87
1.70A19.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		1uj1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.65A19.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		1uj1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.59A19.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		1uj1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.63A19.06
20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU B  86
VAL B 148
GLY B 146
LEU B 177
TYR B  37
1.66A19.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU B  86
VAL B  20
TYR B  37
GLY B  29
LEU B  87
1.65A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU B  86
VAL B  20
TYR B  37
GLY B  29
LEU B  87
1.62A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU B1030
VAL B1091
VAL B1020
LEU B1032
TYR B1037
1.64A19.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 9
LEU B  86
VAL B 148
GLY B 146
LEU B 177
TYR B  37
1.70A18.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.65A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.67A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 10
LEU B 291
ASN B 297
VAL B 277
GLY B 261
TYR B 295
1.50A16.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 11
LEU B 291
VAL B 277
VAL B 259
GLY B 261
TYR B 295
1.73A15.51
17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 10
LEU B 291
VAL B 277
VAL B 259
GLY B 261
TYR B 295
1.64A15.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 10
LEU C 291
LYS C 292
VAL C 277
GLY C 261
TYR C 295
1.36A15.82
None
GOL  C1006 (-2.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 9
LEU C 291
LYS C 292
VAL C 277
GLY C 260
TYR C 295
1.45A15.36
None
GOL  C1006 (-2.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 10
LEU B 291
VAL B 277
VAL B 259
GLY B 261
TYR B 295
1.70A15.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2ajf ACE2
(Homo
sapiens)		5 / 10
LEU B 240
VAL B 604
TYR B 237
GLY B 605
LEU B 595
1.51A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.70A19.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.71A19.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.69A19.31
20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  30
VAL A  91
VAL A  20
LEU A  32
TYR A  37
1.67A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  30
VAL A  91
VAL A  20
LEU A  32
TYR A  37
1.64A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.69A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU S 355
VAL S 328
TYR S 352
GLY S 326
LEU S 421
1.67A16.04
None
None
None
NAG  S1330 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU S 355
VAL S 328
TYR S 352
GLY S 326
LEU S 421
1.64A16.39
None
None
None
NAG  S1330 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
LEU S 355
VAL S 328
TYR S 352
GLY S 326
LEU S 421
1.65A16.04
None
None
None
NAG  S1330 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 10
LEU B 110
VAL B  96
VAL B  78
GLY B  80
TYR B 114
1.71A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 10
LEU B 110
VAL B  96
VAL B  78
GLY B  80
TYR B 114
1.63A15.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 10
LEU A 110
ASN A 116
VAL A  96
GLY A  80
TYR A 114
1.48A15.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 11
LEU A 110
VAL A  96
VAL A  78
GLY A  80
TYR A 114
1.72A15.00
17.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 10
LEU B 110
VAL B  96
VAL B  78
GLY B  80
TYR B 114
1.68A15.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU C 200
VAL C 206
TYR C 208
LEU C 186
GLU C 204
1.40A19.04
20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
LEU C 235
TYR C 214
TYR C 208
GLY C 220
LEU C 186
1.70A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 10
LEU D  45
VAL D 217
TYR D 168
GLY D 233
TRP D 107
1.65A16.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
VAL C 369
CYH C 366
TYR C 367
GLY C 368
LEU C 412
1.76A16.88
17.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 11
LEU D  45
VAL D 217
TYR D 168
GLY D 233
TRP D 107
1.68A16.85
19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 10
LEU D  45
VAL D 217
TYR D 168
GLY D 233
TRP D 107
1.70A16.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 10
LEU A 189
VAL A 141
VAL A 182
GLY A 140
TYR A 324
1.64A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 10
LEU A 189
VAL A 141
VAL A 182
GLY A 140
TYR A 324
1.66A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		2hsx LEADER PROTEIN
P65 HOMOLOG
NSP1
(SARSr-CoV)		5 / 11
VAL A  97
VAL A   9
GLY A  41
LEU A  53
GLU A  44
1.62A11.72
12.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.65A18.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.65A18.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 10
LEU B  30
VAL B  91
VAL B  20
LEU B  32
TYR B  37
1.72A18.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.73A18.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.63A18.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
LEU A 189
VAL A 141
VAL A 182
GLY A 140
TYR A 324
1.55A21.34
23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 10
LEU B 189
VAL B 141
VAL B 182
GLY B 140
TYR B 324
1.64A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 10
LEU A 189
VAL A 141
VAL A 182
GLY A 140
TYR A 324
1.63A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 11
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.62A19.13
20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 9
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.68A18.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 10
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.64A19.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 10
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.58A19.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 10
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.64A19.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.62A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.72A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.72A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 10
LEU A  30
VAL A  91
VAL A  20
LEU A  32
TYR A  37
1.70A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.64A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 10
LEU A  30
VAL A  91
VAL A  20
LEU A  32
TYR A  37
1.67A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.66A19.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 9
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.70A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 11
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.67A19.18
20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 10
LEU B  86
VAL B  20
TYR B  37
GLY B  29
LEU B  87
1.59A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 9
LEU B  86
VAL B  20
TYR B  37
GLY B  29
LEU B  87
1.60A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 10
LEU B  86
VAL B  20
TYR B  37
GLY B  29
LEU B  87
1.67A19.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.63A19.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.66A19.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.63A19.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.60A19.24
20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.56A19.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.68A18.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.71A18.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 10
LEU B 189
VAL B 141
VAL B 182
GLY B 140
TYR B 324
1.68A20.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 10
LEU B 189
VAL B 141
VAL B 182
GLY B 140
TYR B 324
1.63A20.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
LEU F 299
VAL F 236
GLY F 253
LEU F 227
GLU F 210
1.67A20.95
22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.71A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2w2g NSP3
(SARSr-CoV)		5 / 10
LEU A 475
VAL A 448
VAL A 445
GLY A 446
LEU A 412
1.65A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2w2g NSP3
(SARSr-CoV)		5 / 10
LEU A 475
VAL A 448
VAL A 445
GLY A 446
LEU A 412
1.37A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		2w2g NSP3
(SARSr-CoV)		5 / 11
LEU A 475
VAL A 448
VAL A 445
GLY A 446
LEU A 412
1.48A20.25
20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		2w2g NSP3
(SARSr-CoV)		5 / 11
LEU A 475
VAL A 448
VAL A 445
GLY A 446
LEU A 412
1.47A18.90
20.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2w2g NSP3
(SARSr-CoV)		5 / 10
LEU A 475
VAL A 448
VAL A 445
GLY A 446
LEU A 412
1.42A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		2w2g NSP3
(SARSr-CoV)		5 / 10
LEU A 475
VAL A 448
VAL A 445
GLY A 446
LEU A 412
1.62A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2w2g NSP3
(SARSr-CoV)		5 / 10
LEU A 475
VAL A 448
VAL A 445
GLY A 446
LEU A 412
1.55A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2wct NSP3
(SARSr-CoV)		5 / 10
LEU A 475
LYS A 477
VAL A 448
GLY A 446
LEU A 412
1.43A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2wct NSP3
(SARSr-CoV)		5 / 9
LEU C 475
LYS C 476
VAL C 448
GLY C 446
LEU C 412
1.52A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2xyv NSP10
(SARSr-CoV)		5 / 9
LEU B  31
LYS B  28
VAL B 108
GLY B 109
TYR B  30
1.62A12.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.65A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.63A19.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		5 / 10
LEU A 374
VAL A 369
GLY A 418
LEU A 355
TYR A 352
1.70A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		5 / 10
LEU A 374
VAL A 369
GLY A 418
LEU A 355
TYR A 352
1.72A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		5 / 11
LEU A 374
VAL A 369
GLY A 418
LEU A 355
TYR A 352
1.76A16.61
17.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		5 / 10
LEU A 374
VAL A 369
GLY A 418
LEU A 355
TYR A 352
1.74A16.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		3d0g SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU F 421
VAL F 354
TYR F 356
TYR F 352
LEU F 499
1.73A14.03
17.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
LEU B 222
ASN B 397
TYR B 516
GLY B 399
TYR B 217
1.41A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
LEU B 240
VAL B 604
TYR B 243
GLY B 605
TYR B 237
1.66A21.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
LEU B 240
VAL B 604
TYR B 243
GLY B 605
TYR B 237
1.65A21.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
LEU B 240
VAL B 604
TYR B 243
GLY B 605
TYR B 237
1.67A21.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
LEU B 116
VAL B 185
TYR B 199
TYR B 183
LEU B 120
1.66A21.85
21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
LEU B 240
VAL B 604
TYR B 243
GLY B 605
TYR B 237
1.59A21.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.70A18.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.69A18.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU B  86
VAL B 148
GLY B 146
LEU B 177
TYR B  37
1.68A18.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU B  86
VAL B 148
GLY B 146
LEU B 177
TYR B  37
1.62A18.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.68A19.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.65A18.51
20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.65A18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		3e9s NSP3
(SARSr-CoV)		5 / 11
LEU A 200
VAL A 206
TYR A 208
LEU A 186
GLU A 204
1.36A19.18
19.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  30
VAL A  91
VAL A  20
LEU A  32
TYR A  37
1.63A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.69A18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU B  86
VAL B 148
GLY B 146
LEU B 177
TYR B  37
1.71A18.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.71A19.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.69A18.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.72A18.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.68A18.44
21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU B  86
VAL B  20
TYR B  37
GLY B  29
LEU B  87
1.68A18.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU B  86
VAL B 148
GLY B 146
LEU B 177
TYR B  37
1.71A18.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU B  86
VAL B  20
TYR B  37
GLY B  29
LEU B  87
1.66A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		3i6k HLA, A-2
MEMBRANE
GLYCOPROTEIN PEPTIDE
(Homo
sapiens;
SARS-COV
TJF)		5 / 11
LEU C   1
VAL A  34
GLY A  26
TYR A  99
GLU A  63
1.57A1.51
2.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU B  30
VAL B  91
VAL B  20
LEU B  32
TYR B  37
1.63A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU D  86
VAL D  20
TYR D  37
GLY D  29
LEU D  87
1.54A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU D  86
VAL D  20
TYR D  37
GLY D  29
LEU D  87
1.55A19.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  30
VAL A  91
VAL A  20
LEU A  32
TYR A  37
1.66A19.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  30
VAL A  91
VAL A  20
LEU A  32
TYR A  37
1.63A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.69A19.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  30
VAL A  91
VAL A  20
LEU A  32
TYR A  37
1.74A19.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.66A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.65A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.69A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.59A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.63A19.31
20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.66A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.71A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU B 177
VAL B 157
VAL B 104
TYR B 101
LEU B  30
1.72A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.67A18.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU B  86
VAL B 148
GLY B 146
LEU B 177
TYR B  37
1.70A18.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 10
LEU B 235
VAL B 221
TYR B 214
GLY B 220
LEU B 186
1.67A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		3sci ACE2
(Homo
sapiens)		5 / 10
LEU B 116
VAL B 185
TYR B 199
TYR B 183
LEU B 120
1.70A22.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3scj ACE2
(Homo
sapiens)		5 / 10
LEU B 222
ASN B 397
TYR B 516
GLY B 399
TYR B 217
1.44A22.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
LEU A 240
VAL A 604
TYR A 237
GLY A 605
LEU A 595
1.50A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
LEU B 240
VAL B 604
TYR B 243
GLY B 605
TYR B 237
1.53A21.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
LEU B 240
VAL B 604
TYR B 243
GLY B 605
TYR B 237
1.59A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
LEU B 240
VAL B 604
TYR B 243
GLY B 605
TYR B 237
1.62A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
LEU B 240
VAL B 604
TYR B 243
GLY B 605
TYR B 237
1.62A21.93
21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
LEU B 240
VAL B 604
TYR B 243
GLY B 605
TYR B 237
1.61A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.70A18.36
20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.66A18.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.70A18.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.73A18.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.72A18.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.72A18.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		3snd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.80A18.32
20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3snd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A 148
GLY A 146
LEU A 177
TYR A  37
1.71A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		3szn 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.63A19.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU B  86
VAL B  20
TYR B  37
GLY B  29
LEU B  87
1.71A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU B  86
VAL B  20
TYR B  37
GLY B  29
LEU B  87
1.68A18.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.72A19.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.70A18.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 11
LEU A  60
VAL A  75
TYR A  72
LEU A  80
GLU A  64
1.69A21.34
20.37
PO4  A 405 (-4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		4wy3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.69A19.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.71A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.61A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.64A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU A  86
VAL A  20
TYR A  37
GLY A  29
LEU A  87
1.64A17.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
LEU B  30
VAL B  91
VAL B  20
LEU B  32
TYR B  37
1.72A19.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
LEU A 217
VAL A 221
TYR A 234
GLY A 220
TYR A 214
1.60A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
LEU A 217
VAL A 221
TYR A 234
GLY A 220
TYR A 214
1.69A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
LEU A 217
VAL A 221
TYR A 234
GLY A 220
TYR A 214
1.64A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU D 200
VAL D 206
TYR D 208
LEU D 186
GLU D 204
1.41A19.35
21.24
5MW  E  48 ( 3.9A)
None
None
None
5MW  E  48 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
LEU A 217
VAL A 221
TYR A 234
GLY A 220
TYR A 214
1.64A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
LEU A 217
VAL A 221
TYR A 234
GLY A 220
TYR A 214
1.64A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU A 217
VAL A 221
TYR A 234
GLY A 220
TYR A 214
1.68A19.29
21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
LEU A 217
VAL A 221
TYR A 234
GLY A 220
TYR A 214
1.64A21.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
LEU A 217
VAL A 221
TYR A 234
GLY A 220
TYR A 214
1.66A21.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
LEU B 235
TYR B 214
TYR B 208
GLY B 220
LEU B 186
1.70A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU D 200
VAL D 206
TYR D 208
LEU D 186
GLU D 204
1.40A19.56
21.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
VAL B 369
CYH B 366
TYR B 367
GLY B 368
LEU B 412
1.69A18.90
16.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
VAL C 581
VAL C 601
TYR C 598
GLY C 579
LEU C 597
1.69A18.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
VAL C 581
VAL C 601
TYR C 598
GLY C 579
LEU C 597
1.70A18.97
16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
VAL C 581
VAL C 601
TYR C 598
GLY C 579
LEU C 597
1.69A18.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
VAL C 581
VAL C 601
TYR C 598
GLY C 579
LEU C 597
1.68A18.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		5x59 S PROTEIN
(MERS-CoV)		5 / 10
LEU B 873
VAL B1124
VAL B1127
TYR B1135
LEU B1005
1.74A16.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
LEU B 355
VAL B 328
TYR B 352
GLY B 326
LEU B 421
1.69A19.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		5x5f S PROTEIN
(MERS-CoV)		5 / 10
LEU C 608
TYR C 609
GLY C 610
LEU C 638
TYR C 606
1.69A16.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		5x5f S PROTEIN
(MERS-CoV)		5 / 10
VAL C 625
VAL A 329
TYR A  64
GLY A 331
TYR C 641
1.67A16.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU C  58
TYR C  41
TYR C  42
GLY C  39
LEU C 264
1.41A18.56
LEU  C  58 ( 0.6A)
TYR  C  41 ( 1.3A)
TYR  C  42 ( 1.3A)
GLY  C  39 ( 0.0A)
LEU  C 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
LEU C  58
TYR C 197
TYR C  42
GLY C  39
LEU C 264
1.64A18.64
LEU  C  58 ( 0.6A)
TYR  C 197 ( 1.3A)
TYR  C  42 ( 1.3A)
GLY  C  39 ( 0.0A)
LEU  C 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU A  58
VAL A  40
VAL A 186
TYR A  42
LEU A 264
1.66A18.44
15.82
LEU  A  58 ( 0.6A)
VAL  A  40 ( 0.6A)
VAL  A 186 ( 0.6A)
TYR  A  42 ( 1.3A)
LEU  A 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU C 355
VAL C 328
TYR C 352
GLY C 326
LEU C 421
1.69A18.52
LEU  C 355 ( 0.5A)
VAL  C 328 ( 0.6A)
TYR  C 352 ( 1.3A)
GLY  C 326 ( 0.0A)
LEU  C 421 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU C  58
VAL C  40
VAL C 186
TYR C  42
LEU C 264
1.67A18.70
16.01
LEU  C  58 ( 0.6A)
VAL  C  40 ( 0.6A)
VAL  C 186 ( 0.6A)
TYR  C  42 ( 1.3A)
LEU  C 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
LEU C 355
VAL C 328
TYR C 352
GLY C 326
LEU C 421
1.68A18.52
LEU  C 355 ( 0.5A)
VAL  C 328 ( 0.6A)
TYR  C 352 ( 1.3A)
GLY  C 326 ( 0.0A)
LEU  C 421 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU A  58
TYR A 197
TYR A  42
GLY A  39
LEU A 264
1.54A18.70
LEU  A  58 ( 0.6A)
TYR  A 197 ( 1.3A)
TYR  A  42 ( 1.3A)
GLY  A  39 ( 0.0A)
LEU  A 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU C  58
TYR C 197
TYR C  42
GLY C  39
LEU C 264
1.68A18.56
LEU  C  58 ( 0.6A)
TYR  C 197 ( 1.3A)
TYR  C  42 ( 1.3A)
GLY  C  39 ( 0.0A)
LEU  C 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU C  58
TYR C  41
TYR C  42
GLY C  39
LEU C 264
1.64A18.70
LEU  C  58 ( 0.6A)
TYR  C  41 ( 1.3A)
TYR  C  42 ( 1.3A)
GLY  C  39 ( 0.0A)
LEU  C 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU A  58
VAL A  40
VAL A 186
TYR A  42
LEU A 264
1.72A18.70
LEU  A  58 ( 0.6A)
VAL  A  40 ( 0.6A)
VAL  A 186 ( 0.6A)
TYR  A  42 ( 1.3A)
LEU  A 264 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU B  52
VAL C 555
TYR B 266
TYR B  53
LEU B  54
1.65A18.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU A  52
VAL B 555
TYR A 266
TYR A  53
LEU A  54
1.67A18.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU B  52
VAL C 555
TYR B 266
TYR B  53
LEU B  54
1.68A18.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU B  52
VAL C 555
TYR B 266
TYR B  53
LEU B  54
1.70A18.78
16.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU A  52
VAL B 555
TYR A 266
TYR A  53
LEU A  54
1.68A18.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU A 374
ASN A 375
GLY A 512
LEU A 355
TYR A 356
1.68A18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU A  52
VAL B 555
TYR A 266
TYR A  53
LEU A  54
1.64A18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6acj ACE2
(Homo
sapiens)		5 / 10
LEU D 240
VAL D 604
TYR D 243
GLY D 605
TYR D 237
1.52A22.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6acj ACE2
(Homo
sapiens)		5 / 10
LEU D 240
VAL D 604
TYR D 243
GLY D 605
TYR D 237
1.56A22.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6acj ACE2
(Homo
sapiens)		5 / 11
LEU D 240
VAL D 604
TYR D 243
GLY D 605
TYR D 237
1.55A22.24
20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6acj ACE2
(Homo
sapiens)		5 / 10
LEU D 240
VAL D 604
TYR D 243
GLY D 605
TYR D 237
1.54A22.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6acj ACE2
(Homo
sapiens)		5 / 10
LEU D 240
VAL D 604
TYR D 243
GLY D 605
TYR D 237
1.46A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
LEU B 421
VAL B 328
VAL B 354
TYR B 352
GLY B 326
1.50A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
LEU B 421
VAL B 328
VAL B 354
TYR B 352
GLY B 326
1.59A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
LEU B 421
VAL B 328
VAL B 354
TYR B 352
GLY B 326
1.59A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
LEU B 421
VAL B 328
VAL B 354
TYR B 352
GLY B 326
1.56A19.25
16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
LEU B 421
VAL B 328
VAL B 354
TYR B 352
GLY B 326
1.53A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
LEU B 421
VAL B 328
VAL B 354
TYR B 352
GLY B 326
1.58A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
LEU B 421
VAL B 328
TYR B 352
GLY B 326
LEU B 499
1.67A18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
LEU B 421
VAL B 328
VAL B 354
GLY B 326
LEU B 499
1.53A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
VAL B  40
VAL B 186
TYR B  42
GLY B  39
LEU B 264
1.74A19.14
16.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
ASN C 304
VAL C 581
TYR C 598
GLY C 580
LEU C 615
1.45A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 10
LEU A  95
TYR A 118
TYR A 123
LEU C  10
TYR A  74
1.75A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 9
LEU A  95
TYR A 118
TYR A 123
LEU C  10
TYR A  74
1.66A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6jyt HELICASE
(SARSr-CoV)		5 / 10
LEU B 165
VAL B 210
TYR B 198
TYR B 211
LEU B 163
1.74A20.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6jyt HELICASE
(SARSr-CoV)		5 / 11
LEU A 581
VAL A 456
CYH A 556
LEU A 585
GLU A 551
1.74A20.96
19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6m0j ACE2
(Homo
sapiens)		5 / 11
LEU A 539
GLY A 537
LEU A 410
TYR A 587
GLU A 527
1.70A21.94
20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m18 ACE2
(Homo
sapiens)		5 / 10
LEU B 116
VAL B 185
TYR B 199
TYR B 183
LEU B 120
1.67A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 10
ASN C 435
VAL C 125
TYR C 128
GLY C 126
LEU C  52
1.65A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6m18 ACE2
SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
LEU D 624
GLY D 629
LEU D 717
TYR D 633
GLU C 352
1.76A20.89
18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6m18 ACE2
(Homo
sapiens)		5 / 10
LEU B 116
VAL B 185
TYR B 199
TYR B 183
LEU B 120
1.66A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6m18 ACE2
(Homo
sapiens)		5 / 10
LEU B 116
VAL B 185
TYR B 199
TYR B 183
LEU B 120
1.75A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6m18 ACE2
(Homo
sapiens)		5 / 10
LEU B 116
VAL B 185
TYR B 199
TYR B 183
LEU B 120
1.65A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
VAL A  79
VAL A 304
TYR A  87
TRP A 534
GLU A 300
1.29A20.68
19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m1d ACE2
(Homo
sapiens)		5 / 10
VAL B 209
VAL B 212
TYR B 215
TYR B 217
GLY B 211
1.41A20.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6m1d ACE2
(Homo
sapiens)		5 / 11
VAL D 209
VAL D 212
TYR D 217
GLY D 211
GLU D 571
1.30A20.60
18.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
VAL A 324
TYR A 322
GLY A 326
LEU A 398
GLU A 391
1.73A20.50
18.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ASN A 889
VAL A 893
TYR A1029
GLY A 892
LEU A1031
1.70A17.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		5 / 10
LEU H  81
VAL H 123
TYR H  94
GLY H   8
LEU H  79
1.55A17.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6nur NSP12
(SARSr-CoV)		5 / 9
LEU A 127
VAL A 182
TYR A 175
GLY A 179
LEU A 146
1.70A20.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6nus NSP12
(SARSr-CoV)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.71A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6nus NSP12
(SARSr-CoV)		5 / 11
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.73A20.27
18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6nus NSP12
(SARSr-CoV)		5 / 11
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.64A20.25
18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6nus NSP12
(SARSr-CoV)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.70A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6nus NSP12
(SARSr-CoV)		5 / 10
ASN A 790
VAL A 792
VAL A 785
TYR A 788
TYR A 787
1.68A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6nus NSP12
(SARSr-CoV)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.72A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6nus NSP12
(SARSr-CoV)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.63A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6vw1 ACE2
(Homo
sapiens)		5 / 9
LEU B 116
VAL B 185
TYR B 199
TYR B 183
LEU B 120
1.65A22.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6vw1 ACE2
(Homo
sapiens)		5 / 10
LEU B 116
VAL B 185
TYR B 199
TYR B 183
LEU B 120
1.65A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6vw1 ACE2
(Homo
sapiens)		5 / 10
LEU B 116
VAL B 185
TYR B 199
TYR B 183
LEU B 120
1.58A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6vw1 ACE2
(Homo
sapiens)		5 / 11
LEU B 116
VAL B 185
TYR B 199
TYR B 183
LEU B 120
1.52A22.15
20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6vw1 ACE2
(Homo
sapiens)		5 / 10
LEU B 116
VAL B 185
TYR B 199
TYR B 183
LEU B 120
1.55A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		6vw1 ACE2
(Homo
sapiens)		5 / 10
LEU B 116
VAL B 185
TYR B 199
TYR B 183
LEU B 120
1.61A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6vw1 ACE2
(Homo
sapiens)		5 / 10
LEU B 116
VAL B 185
TYR B 199
TYR B 183
LEU B 120
1.58A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 10
LEU H  45
VAL L  85
TYR L  36
GLY L 101
TRP H 103
1.73A13.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 10
LEU H  45
VAL L  85
TYR L  36
GLY L 101
TRP H 103
1.77A14.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 10
LEU H  45
VAL L  85
TYR L  36
GLY L 101
TRP H 103
1.73A13.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 10
LEU H  45
VAL L  85
TYR L  36
GLY L 101
TRP H 103
1.66A13.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 11
TYR H  90
GLY H 106
TRP H  82
LEU H  80
GLU H  10
1.72A14.98
14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 11
TYR H  90
GLY H 106
TRP H  82
LEU H  80
GLU H  10
1.64A13.33
17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 11
LEU H  45
VAL L  85
TYR L  36
GLY L 101
TRP H 103
1.68A13.33
17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
TYR H  94
GLY H 112
TRP H  83
LEU H  81
GLU H  10
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 10
LEU H  45
VAL L  91
TYR L  42
GLY L 107
TRP H 109
1.79A
None
1PE  L1603 ( 4.8A)
None
1PE  L1603 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 11
LEU L  52
VAL H 108
GLY H  98
TYR L  42
GLU L  61
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 11
LEU C  52
TYR C  55
TYR C  97
GLY B  99
GLU C  61
1.70A
None
DMS  A 905 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
TYR B  94
GLY B 112
TRP B  83
LEU B  81
GLU B  10
1.69A
None
MLI  B 304 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
TYR B  94
GLY B 112
TRP B  83
LEU B  81
GLU B  10
1.67A
None
MLI  B 304 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 11
LEU C  52
VAL B 108
GLY B  98
TYR C  42
GLU C  61
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
TYR H  94
GLY H 112
TRP H  83
LEU H  81
GLU H  10
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 11
LEU L  52
TYR L  55
TYR L  97
GLY H  99
GLU L  61
1.70A
None
DMS  L1601 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 11
TYR H  94
GLY H 112
TRP H  83
LEU H  81
GLU H  10
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 11
TYR H  94
GLY H 112
TRP H  83
LEU H  81
GLU H  10
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 11
LEU L  52
TYR L  55
TYR L  97
GLY H  99
GLU L  61
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 11
LEU C  52
TYR C  55
TYR C  97
GLY B  99
GLU C  61
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
TYR H  94
GLY H 112
TRP H  83
LEU H  81
GLU H  10
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
TYR B  94
GLY B 112
TRP B  83
LEU B  81
GLU B  10
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
TYR B  94
GLY B 112
TRP B  83
LEU B  81
GLU B  10
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 10
LEU H  45
VAL L  91
TYR L  42
GLY L 107
TRP H 109
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 11
LEU C  52
VAL B 108
GLY B  98
TYR C  42
GLU C  61
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 11
LEU L  52
TYR L  55
TYR L  97
GLY H  99
GLU L  61
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 11
LEU L  52
VAL H 108
GLY H  98
TYR L  42
GLU L  61
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
TYR H  94
GLY H 112
TRP H  83
LEU H  81
GLU H  10
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 10
LEU B  45
VAL C  91
TYR C  42
GLY C 107
TRP B 109
1.79A
None