Ligand ID: EFZ


Drugbank ID:
DB00625
(Efavirenz)


Indication:
For use in combination treatment of HIV infection (AIDS)

Get human targets for EFZ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'EFZ' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.74A14.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.77A14.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.77A13.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 11
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.77A19.02

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.68A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.80A19.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.76A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.74A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 9
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.75A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.72A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 10
LEU D 177
VAL D 157
VAL D 104
TYR D 101
LEU D  30
1.79A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.76A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 10
LEU B 177
VAL B 157
VAL B 104
TYR B 101
LEU B  30
1.77A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.78A18.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU B 177
VAL B 157
VAL B 104
TYR B 101
LEU B  30
1.79A18.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 10
LEU D 177
VAL D  86
TYR D 161
GLY D 179
LEU D  30
1.75A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 10
LEU C 177
VAL C  86
TYR C 161
GLY C 179
LEU C  30
1.78A18.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 10
LEU C 177
VAL C  86
TYR C 161
GLY C 179
LEU C  30
1.71A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 10
LEU C  30
VAL C  91
VAL C  20
LEU C  32
TYR C  37
1.71A18.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.78A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 9
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.78A18.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 11
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.78A18.69

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.77A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.69A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.77A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 9
VAL A 233
TYR A 238
TYR A 237
LEU A 240
TYR A 732
1.71A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.73A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.79A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
LEU A 749
VAL A 704
VAL A 475
TYR A 479
TYR A 748
1.74A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
LEU A 131
VAL A 182
TYR A 175
GLY A 179
LEU A 127
1.68A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
VAL A 233
TYR A 238
TYR A 237
LEU A 240
TYR A 732
1.70A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
VAL A 233
TYR A 238
TYR A 237
LEU A 240
TYR A 732
1.64A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6m71 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.79A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL C  62
VAL C  90
TYR C 266
GLY C 268
LEU C 216
1.74A17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
VAL C  62
TYR C 266
GLY C 268
LEU C 216
GLU C 191
1.70A17.70
16.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
VAL C  62
VAL C  90
TYR C 266
GLY C 268
LEU C 216
1.72A18.42
16.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL C  62
VAL C  90
TYR C 266
GLY C 268
LEU C 216
1.72A18.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6vxs NSP3
(SARS-CoV-2)		5 / 11
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6vxs NSP3
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.79A
None
None
None
SO4  A 201 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6vxs NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.73A
None
None
None
SO4  A 201 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6vxs NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  78
TYR A 113
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		6vxs NSP3
(SARS-CoV-2)		5 / 9
LEU B 109
LYS B 110
VAL B  95
GLY B  78
TYR B 113
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6vxs NSP3
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  78
TYR B 113
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6vxs NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.75A
None
None
None
SO4  A 201 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6vxs NSP3
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6vxs NSP3
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6vxs NSP3
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.75A
None
None
None
SO4  A 201 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6vxs NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  78
TYR A 113
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6vxs NSP3
(SARS-CoV-2)		5 / 11
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6vxs NSP3
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6vxs NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.66A
None
None
None
SO4  A 201 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL A  62
VAL A  90
TYR A 266
GLY A 268
LEU A 216
1.73A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL A  62
VAL A  90
TYR A 266
GLY A 268
LEU A 216
1.62A17.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
VAL A  62
VAL A  90
TYR A 266
GLY A 268
LEU A 216
1.74A17.71
16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL A  62
VAL A  90
TYR A 266
GLY A 268
LEU A 216
1.68A18.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL A  62
VAL A  90
TYR A 266
GLY A 268
LEU A 216
1.63A17.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
VAL A  62
VAL A  90
TYR A 266
GLY A 268
LEU A 216
1.63A17.57
16.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL A  62
VAL A  90
TYR A 266
GLY A 268
LEU A 216
1.63A17.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.60A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 9
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.59A21.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.54A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.61A21.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.64A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 9
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.54A20.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.54A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.49A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.54A21.08
22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.51A21.48
23.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6w02 NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
ASN A 115
VAL A  95
GLY A  79
TYR A 113
1.51A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		6w02 NSP3
(SARS-CoV-2)		5 / 9
LEU B 109
LYS B 110
VAL B  95
GLY B  79
TYR B 113
1.48A17.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w02 NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.63A17.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w02 NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.68A17.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6w02 NSP3
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.72A17.06
18.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6w02 NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.71A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6w37 PROTEIN 7A
(SARS-CoV-2)		5 / 10
LEU A  41
ASN A  28
TYR A  60
GLY A  27
LEU A  62
1.67A8.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6w4h NSP16
(SARS-CoV-2)		5 / 11
VAL A6965
TYR A7009
GLY A7006
LEU A6981
GLU A7015
1.51A18.57
20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w6y NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6w6y NSP3
(SARS-CoV-2)		5 / 11
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.74A15.02
17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w6y NSP3
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6w6y NSP3
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.79A14.65
17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w6y NSP3
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6w6y NSP3
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.76A15.02
17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w6y NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6w6y NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6w6y NSP3
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6w6y NSP3
(SARS-CoV-2)		5 / 11
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.77A14.65
17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w75 NSP10
(SARS-CoV-2)		5 / 10
LEU B4328
VAL D4274
TYR B4283
LEU B4365
TYR B4329
1.66A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6w75 NSP10
(SARS-CoV-2)		5 / 11
LEU B4328
VAL D4274
TYR B4283
LEU B4365
TYR B4329
1.72A12.77
15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6w75 NSP10
(SARS-CoV-2)		5 / 9
LEU D4328
VAL B4274
TYR D4283
LEU D4365
TYR D4329
1.73A13.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6w75 NSP10
(SARS-CoV-2)		5 / 9
LEU B4328
VAL D4274
TYR B4283
LEU B4365
TYR B4329
1.69A13.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w75 NSP10
(SARS-CoV-2)		5 / 10
LEU D4328
VAL B4274
TYR D4283
LEU D4365
TYR D4329
1.72A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		6w75 NSP10
(SARS-CoV-2)		5 / 10
LEU B4328
VAL D4274
TYR B4283
LEU B4365
TYR B4329
1.78A13.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6w75 NSP10
(SARS-CoV-2)		5 / 11
LEU D4328
VAL B4274
TYR D4283
LEU D4365
TYR D4329
1.78A12.77
15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6w75 NSP16
(SARS-CoV-2)		5 / 11
VAL C6965
TYR C7009
GLY C7006
LEU C6981
GLU C7015
1.42A14.00
15.49
None
NA  C7103 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 10
LEU B 113
TYR B  95
GLY B 287
TRP B  93
TYR B 112
1.79A
None
None
CL  B 502 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
LEU C 113
TYR C  95
GLY C 287
TRP C  93
TYR C 112
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 10
LEU C 113
TYR C  95
GLY C 287
TRP C  93
TYR C 112
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
LEU B 113
TYR B  95
GLY B 287
TRP B  93
TYR B 112
1.76A
None
None
CL  B 502 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 10
LEU B 113
TYR B  95
GLY B 287
TRP B  93
TYR B 112
1.80A20.92
None
None
CL  B 502 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
LEU A 199
VAL A 205
TYR A 207
LEU A 185
GLU A 203
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 10
LEU B 113
TYR B  95
GLY B 287
TRP B  93
TYR B 112
1.75A
None
None
CL  B 502 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wcf NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wcf NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6wcf NSP3
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wcf NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
ASN A 115
VAL A  95
GLY A  79
TYR A 113
1.44A16.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wcf NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6wcf NSP3
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wcf NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  78
TYR A 113
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wcf NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
LYS A 110
VAL A  95
GLY A  79
TYR A 113
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wen NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6wen NSP3
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6wen NSP3
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wen NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
ASN A 115
VAL A  95
GLY A  79
TYR A 113
1.50A16.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wen NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wen NSP3
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6wey NSP3
(SARS-CoV-2)		5 / 11
LEU A 313
VAL A 299
VAL A 281
GLY A 283
TYR A 317
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wey NSP3
(SARS-CoV-2)		5 / 10
LEU A 313
VAL A 299
VAL A 281
GLY A 283
TYR A 317
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wey NSP3
(SARS-CoV-2)		5 / 10
LEU A 357
ASN A 219
VAL A 351
VAL A 348
TYR A 317
1.74A16.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6wey NSP3
(SARS-CoV-2)		5 / 11
LEU A 313
VAL A 299
VAL A 281
GLY A 283
TYR A 317
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wey NSP3
(SARS-CoV-2)		5 / 10
LEU A 313
VAL A 299
VAL A 281
GLY A 283
TYR A 317
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wey NSP3
(SARS-CoV-2)		5 / 10
LEU A 313
VAL A 299
VAL A 281
GLY A 283
TYR A 317
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6wjt NSP10
(SARS-CoV-2)		5 / 11
LEU B4328
VAL D4274
TYR B4283
LEU B4365
TYR B4329
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		6wjt NSP10
(SARS-CoV-2)		5 / 10
LEU B4328
VAL D4274
TYR B4283
LEU B4365
TYR B4329
1.75A13.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wjt NSP10
(SARS-CoV-2)		5 / 10
LEU B4328
VAL D4274
TYR B4283
LEU B4365
TYR B4329
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wjt NSP10
(SARS-CoV-2)		5 / 10
LEU B4328
VAL D4274
TYR B4283
LEU B4365
TYR B4329
1.63A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
VAL C6965
TYR C7009
GLY C7006
LEU C6981
GLU C7015
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6wjt NSP10
(SARS-CoV-2)		5 / 9
LEU D4328
VAL B4274
TYR D4283
LEU D4365
TYR D4329
1.71A13.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6wjt NSP10
(SARS-CoV-2)		5 / 9
LEU B4328
VAL D4274
TYR B4283
LEU B4365
TYR B4329
1.66A13.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wjt NSP10
(SARS-CoV-2)		5 / 10
LEU B4328
VAL D4274
TYR B4283
LEU B4365
TYR B4329
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		6wjt NSP10
(SARS-CoV-2)		5 / 10
LEU D4328
VAL B4274
TYR D4283
LEU D4365
TYR D4329
1.80A13.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wjt NSP10
(SARS-CoV-2)		5 / 10
LEU D4328
VAL B4274
TYR D4283
LEU D4365
TYR D4329
1.70A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6wkq NSP10
(SARS-CoV-2)		5 / 9
LEU D4328
VAL B4274
TYR D4283
LEU D4365
TYR D4329
1.73A13.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wkq NSP10
(SARS-CoV-2)		5 / 10
LEU D4328
VAL B4274
TYR D4283
LEU D4365
TYR D4329
1.73A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6wkq NSP10
(SARS-CoV-2)		5 / 11
LEU D4328
VAL B4274
TYR D4283
LEU D4365
TYR D4329
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wkq NSP10
(SARS-CoV-2)		5 / 10
LEU B4328
VAL D4274
TYR B4283
LEU B4365
TYR B4329
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6wkq NSP16
(SARS-CoV-2)		5 / 11
VAL C6965
TYR C7009
GLY C7006
LEU C6981
GLU C7015
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		6wkq NSP10
(SARS-CoV-2)		5 / 10
LEU B4328
VAL D4274
TYR B4283
LEU B4365
TYR B4329
1.78A13.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6wkq NSP10
(SARS-CoV-2)		5 / 9
LEU B4328
VAL D4274
TYR B4283
LEU B4365
TYR B4329
1.68A13.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wkq NSP10
(SARS-CoV-2)		5 / 10
LEU B4328
VAL D4274
TYR B4283
LEU B4365
TYR B4329
1.65A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6wkq NSP10
(SARS-CoV-2)		5 / 11
LEU B4328
VAL D4274
TYR B4283
LEU B4365
TYR B4329
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.65A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU B 190
VAL B 142
VAL B 183
GLY B 141
TYR B 325
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU B 190
VAL B 142
VAL B 183
GLY B 141
TYR B 325
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.60A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 183
VAL A 187
TYR A 180
LEU A  76
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU B 190
VAL B 142
TYR B 180
GLY B 141
TYR B 325
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 142
VAL A 183
GLY A 141
TYR A 325
1.66A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
LEU B 190
VAL B 142
TYR B 180
GLY B 141
TYR B 325
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU B 190
VAL B 142
TYR B 180
GLY B 141
TYR B 325
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU B 190
VAL B 142
TYR B 180
GLY B 141
TYR B 325
1.66A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 183
VAL A 187
TYR A 180
LEU A  76
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU B 190
VAL B 142
TYR B 180
GLY B 141
TYR B 325
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU B 190
VAL B 183
VAL B 187
TYR B 180
LEU B  76
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU B 190
VAL B 142
TYR B 180
GLY B 141
TYR B 325
1.65A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
LEU B 190
VAL B 142
TYR B 180
GLY B 141
TYR B 325
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 9
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.62A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU B 190
VAL B 142
VAL B 183
GLY B 141
TYR B 325
1.70A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU B 190
VAL B 183
VAL B 187
TYR B 180
LEU B  76
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 9
LEU B 190
VAL B 142
TYR B 180
GLY B 141
TYR B 325
1.65A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 9
LEU B 190
VAL B 142
TYR B 180
GLY B 141
TYR B 325
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 9
LEU A 190
VAL A 142
TYR A 180
GLY A 141
TYR A 325
1.59A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
LEU A 190
VAL A 183
VAL A 187
TYR A 180
LEU A  76
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU A 190
VAL A 183
VAL A 187
TYR A 180
LEU A  76
1.77A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
LEU B 190
VAL B 142
VAL B 183
GLY B 141
TYR B 325
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
LEU B 190
VAL B 142
TYR B 180
GLY B 141
TYR B 325
1.70A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.78A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  78
TYR B 113
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  78
TYR B 113
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU D 109
VAL D  95
VAL D  77
GLY D  79
TYR D 113
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU D 109
VAL D  95
VAL D  77
GLY D  79
TYR D 113
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU D 109
VAL D  95
VAL D  77
GLY D  79
TYR D 113
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU D 109
VAL D  95
VAL D  77
GLY D  79
TYR D 113
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU B 109
ASN B 115
VAL B  95
GLY B  79
TYR B 113
1.46A15.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU D 109
VAL D  95
VAL D  77
GLY D  79
TYR D 113
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
VAL A6965
TYR A7009
GLY A7006
LEU A6981
GLU A7015
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.76A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.77A18.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 10
LEU A 234
VAL A 220
TYR A 213
GLY A 219
LEU A 185
1.78A20.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6y2f REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.69A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.77A13.31
None
None
None
DMS  A 407 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.77A13.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 10
LEU A 517
VAL A 382
TYR C  55
GLY A 381
LEU A 390
1.49A
None
DMS  A 905 (-4.3A)
DMS  A 905 (-4.3A)
None
DMS  A 905 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 10
LEU A 517
VAL A 382
TYR C  55
GLY A 381
LEU A 390
1.40A
None
DMS  A 905 (-4.3A)
DMS  A 905 (-4.3A)
None
DMS  A 905 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 10
LEU A 517
VAL A 382
TYR C  55
GLY A 381
LEU A 390
1.60A16.94
None
DMS  A 905 (-4.3A)
DMS  A 905 (-4.3A)
None
DMS  A 905 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 11
LEU A 517
VAL A 382
TYR C  55
GLY A 381
LEU A 390
1.48A
None
DMS  A 905 (-4.3A)
DMS  A 905 (-4.3A)
None
DMS  A 905 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 9
LEU A 517
VAL A 382
TYR C  55
GLY A 381
LEU A 390
1.57A16.94
None
DMS  A 905 (-4.3A)
DMS  A 905 (-4.3A)
None
DMS  A 905 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.78A18.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.75A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU D 109
VAL D  95
VAL D  77
GLY D  79
TYR D 113
1.80A
EDO  D 204 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU D 109
VAL D  95
VAL D  77
GLY D  79
TYR D 113
1.77A
EDO  D 204 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU E 109
LYS E 110
VAL E  95
GLY E  78
TYR E 113
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU E 109
VAL E  95
VAL E  77
GLY E  79
TYR E 113
1.73A
None
None
None
EPE  E 203 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU E 109
VAL E  95
VAL E  77
GLY E  79
TYR E 113
1.73A
None
None
None
EPE  E 203 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU D 109
VAL D  95
VAL D  77
GLY D  79
TYR D 113
1.75A
EDO  D 204 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU D 109
VAL D  95
VAL D  77
GLY D  79
TYR D 113
1.72A
EDO  D 204 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU E 109
VAL E  95
VAL E  77
GLY E  79
TYR E 113
1.64A
None
None
None
EPE  E 203 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.68A
None
None
None
EPE  C 202 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.74A
None
None
None
EPE  C 202 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU D 109
VAL D  95
VAL D  77
GLY D  79
TYR D 113
1.67A
EDO  D 204 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.77A
None
None
None
EPE  C 202 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.76A
None
None
None
EPE  C 202 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU E 109
VAL E  95
VAL E  77
GLY E  79
TYR E 113
1.70A
None
None
None
EPE  E 203 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU E 109
VAL E  95
VAL E  77
GLY E  79
TYR E 113
1.77A
None
None
None
EPE  E 203 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU E 109
ASN E 115
VAL E  95
GLY E  79
TYR E 113
1.54A15.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU E 109
VAL E  95
VAL E  77
GLY E  79
TYR E 113
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU D 109
VAL D  95
VAL D  77
GLY D  79
TYR D 113
1.75A
None
None
None
EDO  D 203 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU E 109
VAL E  95
VAL E  77
GLY E  79
TYR E 113
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU D 109
VAL D  95
VAL D  77
GLY D  79
TYR D 113
1.72A
None
None
None
EDO  D 203 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU E 109
VAL E  95
VAL E  77
GLY E  79
TYR E 113
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU D 109
VAL D  95
VAL D  77
GLY D  79
TYR D 113
1.79A
None
None
None
EDO  D 203 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU E 109
LYS E 110
VAL E  95
GLY E  78
TYR E 113
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU D 109
VAL D  95
VAL D  77
GLY D  79
TYR D 113
1.66A
None
None
None
EDO  D 203 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU A 109
ASN A 115
VAL A  95
GLY A  79
TYR A 113
1.53A15.92
None
EDO  A 207 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU E 109
VAL E  95
VAL E  77
GLY E  79
TYR E 113
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU E 109
VAL E  95
VAL E  77
GLY E  79
TYR E 113
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU B 109
ASN B 115
VAL B  95
GLY B  79
TYR B 113
1.54A15.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU D 109
VAL D  95
VAL D  77
GLY D  79
TYR D 113
1.75A
None
None
None
EDO  D 203 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.71A
None
None
None
EDO  A 204 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.73A
None
None
None
EDO  A 204 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.65A
None
None
None
EDO  A 204 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
LEU C 109
VAL C  95
VAL C  77
GLY C  79
TYR C 113
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.74A
None
None
None
EDO  A 204 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU B 109
VAL B  95
VAL B  77
GLY B  79
TYR B 113
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU A 109
VAL A  95
VAL A  77
GLY A  79
TYR A 113
1.78A
None
None
None
EDO  A 204 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.80A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		7bqy MAIN PROTEASE

(SARS-CoV-2;
synthetic
construct)		5 / 11
VAL A  42
VAL A  86
CYH A  85
TYR A  54
LEU C   4
1.74A
None
None
None
None
PJE  C   5 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		7btf NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7btf NSP12
(SARS-CoV-2)		5 / 10
VAL A 233
TYR A 238
TYR A 237
LEU A 240
TYR A 732
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 9
LEU A 127
VAL A 182
TYR A 175
GLY A 179
LEU A 146
1.78A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 10
VAL A 233
TYR A 238
TYR A 237
LEU A 240
TYR A 732
1.74A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 9
VAL A 233
TYR A 238
TYR A 237
LEU A 240
TYR A 732
1.77A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		7btf NSP12
(SARS-CoV-2)		5 / 11
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7btf NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.77A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.79A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7btf NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A  86
TYR A 161
GLY A 179
LEU A  30
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 10
LEU A 177
VAL A 157
VAL A 104
TYR A 101
LEU A  30
1.76A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 9
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.77A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.71A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
VAL A 233
TYR A 238
TYR A 237
LEU A 240
TYR A 732
1.75A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
LEU A 127
VAL A 182
TYR A 175
GLY A 179
LEU A 146
1.79A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
LEU A 127
VAL A 182
TYR A 175
GLY A 179
LEU A 146
1.76A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.75A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 9
LEU A 127
VAL A 182
TYR A 175
GLY A 179
LEU A 146
1.73A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
LEU A 127
VAL A 182
TYR A 175
GLY A 179
LEU A 146
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
LEU A 131
VAL A 182
TYR A 175
GLY A 179
LEU A 127
1.70A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.75A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 9
VAL A 233
TYR A 238
TYR A 237
LEU A 240
TYR A 732
1.78A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
LEU A 127
VAL A 182
TYR A 175
GLY A 179
LEU A 146
1.78A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
VAL A 233
TYR A 238
TYR A 237
LEU A 240
TYR A 732
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
LEU A 127
VAL A 182
TYR A 175
GLY A 179
LEU A 146
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
LEU A 127
VAL A 182
TYR A 175
GLY A 179
LEU A 146
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
LEU A 127
VAL A 182
TYR A 175
GLY A 179
LEU A 146
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.77A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.78A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 9
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.79A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
LEU A 127
VAL A 182
TYR A 175
GLY A 179
LEU A 146
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSH_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT
REVERSE
TRANSCRIPTASE P51
SUBUNIT)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 9
VAL A 233
TYR A 238
TYR A 237
LEU A 240
TYR A 732
1.72A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
LEU A 131
VAL A 182
TYR A 175
GLY A 179
LEU A 127
1.80A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
LEU A 247
VAL A 182
GLY A 179
LEU A 172
TYR A 175
1.72A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
LEU A 127
VAL A 182
TYR A 175
GLY A 179
LEU A 146
1.79A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 9
LEU A 127
VAL A 182
TYR A 175
GLY A 179
LEU A 146
1.75A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
LEU A 127
VAL A 182
TYR A 175
GLY A 179
LEU A 146
1.80A20.08
None