LIST OF BINDING INTERFACES for query 'THYMIDYLATE SYNTHASE' in category 'PROTEIN NAME'

(Click on the 'Details' column to view details on interfaces and similar patterns of amino acids)
Click on the 'View' column to view patterns on the structural viewer)

PDB	Ligand	Drug	Indication	Macromolecule/ Organism	Pfam	Binding_Interfaces (View)	Details
1hvy	D16	Raltitrexed (DB00293)	Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer.	THYMIDYLATE SYNTHASE (Homo sapiens)	Thymidylat_synt	1HVY_A_D16A414	Details
1j3j	CP6	Pyrimethamine (DB00205)	Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria.	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Plasmodium falciparum)	DHFR_1	1J3J_A_CP6A609	Details
2bl9	CP6	Pyrimethamine (DB00205)	Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria.	DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Plasmodium vivax)	DHFR_1	2BL9_A_CP6A1240	Details
2kce	D16	Raltitrexed (DB00293)	Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer.	THYMIDYLATE SYNTHASE (Escherichia coli)	Thymidylat_synt	2KCE_A_D16A566	Details
3nrr	D16	Raltitrexed (DB00293)	Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer.	DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Babesia bovis)	DHFR_1 Thymidylat_synt	3NRR_A_D16A520  3NRR_A_D16A530	Details
3qfx	CP6	Pyrimethamine (DB00205)	Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria.	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Trypanosoma brucei rhodesiense)	DHFR_1	3QFX_A_CP6A602	Details
4eb4	D16	Raltitrexed (DB00293)	Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer.	THYMIDYLATE SYNTHASE (Mus musculus)	Thymidylat_synt	4EB4_A_D16A402	Details
4fox	D16	Raltitrexed (DB00293)	Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer.	THYMIDYLATE SYNTHASE (Mycobacterium tuberculosis)	Thymidylat_synt	4FOX_A_D16A301	Details
4iqq	D16	Raltitrexed (DB00293)	Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer.	THYMIDYLATE SYNTHASE (Caenorhabditis elegans)	Thymidylat_synt	4IQQ_A_D16A402	Details
6aog	CP6	Pyrimethamine (DB00205)	Pyrimethamine is an antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria.	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasma gondii)	Thymidylat_synt	6AOG_A_CP6A704	Details
6gyj	FGT	Phenolphthalein (DB04824)	Phenolphthalein is a drug used for symptomatic relief of constipation and bowel cleansing prior to medical procedures.	THYMIDYLATE SYNTHASE (Mus musculus)	Thymidylat_synt	6GYJ_A_FGTA502	Details
6k7s	D16	Raltitrexed (DB00293)	Raltitrexed is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer.	THYMIDYLATE SYNTHASE (Penaeus vannamei)	Thymidylat_synt	6K7S_A_D16A302	Details
6qya	FFO	Levoleucovorin (DB11596)	Levoleucovorin is a folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer.	THYMIDYLATE SYNTHASE (Enterococcus faecalis)	Thymidylat_synt	6QYA_B_FFOB401	Details
6qyq	FFO	Levoleucovorin (DB11596)	Levoleucovorin is a folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer.	THYMIDYLATE SYNTHASE (Homo sapiens)	Thymidylat_synt	6QYQ_B_FFOB402	Details
6y08	08D	Sulfamethoxazole (DB01015)	Sulfamethoxazole is an oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract.	THYMIDYLATE SYNTHASE (Mus musculus)	Thymidylat_synt	6Y08_A_08DA502	Details
PDB	Ligand	Drug	Indication	Macromolecule/ Organism	Pfam	Binding_Interfaces (View)	Details

[["1hvy","D16","Raltitrexed (DB00293)","Homo sapiens","THYMIDYLATE SYNTHASE","Thymidylat_synt"],["1j3j","CP6","Pyrimethamine (DB00205)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","DHFR_1"],["2bl9","CP6","Pyrimethamine (DB00205)","Plasmodium vivax","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","DHFR_1"],["2kce","D16","Raltitrexed (DB00293)","Escherichia coli","THYMIDYLATE SYNTHASE","Thymidylat_synt"],["3nrr","D16","Raltitrexed (DB00293)","Babesia bovis","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","DHFR_1;Thymidylat_synt"],["3qfx","CP6","Pyrimethamine (DB00205)","Trypanosoma brucei rhodesiense","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","DHFR_1"],["4eb4","D16","Raltitrexed (DB00293)","Mus musculus","THYMIDYLATE SYNTHASE","Thymidylat_synt"],["4fox","D16","Raltitrexed (DB00293)","Mycobacterium tuberculosis","THYMIDYLATE SYNTHASE","Thymidylat_synt"],["4iqq","D16","Raltitrexed (DB00293)","Caenorhabditis elegans","THYMIDYLATE SYNTHASE","Thymidylat_synt"],["6aog","CP6","Pyrimethamine (DB00205)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","Thymidylat_synt"],["6gyj","FGT","Phenolphthalein (DB04824)","Mus musculus","THYMIDYLATE SYNTHASE","Thymidylat_synt"],["6k7s","D16","Raltitrexed (DB00293)","Penaeus vannamei","THYMIDYLATE SYNTHASE","Thymidylat_synt"],["6qya","FFO","Levoleucovorin (DB11596)","Enterococcus faecalis","THYMIDYLATE SYNTHASE","Thymidylat_synt"],["6qyq","FFO","Levoleucovorin (DB11596)","Homo sapiens","THYMIDYLATE SYNTHASE","Thymidylat_synt"],["6y08","08D","Sulfamethoxazole (DB01015)","Mus musculus","THYMIDYLATE SYNTHASE","Thymidylat_synt"]]