LIST OF BINDING INTERFACES for query 'DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1' in category 'PROTEIN NAME'

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PDB	Ligand	Drug	Indication	Macromolecule/ Organism	Pfam	Binding_Interfaces (View)	Details
4an2	EUI	Cobimetinib (DB05239)	Cobimetinib is an antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma.	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens)	Pkinase	4AN2_A_EUIA1382	Details
4lmn	EUI	Cobimetinib (DB05239)	Cobimetinib is an antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma.	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens)	Pkinase	4LMN_A_EUIA503	Details
4u7z	3EW	Selumetinib (DB11689)	Selumetinib is a MEK 1/2 inhibitor used in pediatric patients to treat neurofibromatosis type 1 (NF1) accompanied by symptomatic, inoperable plexiform neurofibromas (PN).	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens)	Pkinase	4U7Z_A_3EWA502	Details
7jur	QOM	Trametinib (DB08911)	Trametinib is a kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1; KINASE SUPPRESSOR OF RAS 2 (Homo sapiens; oryctolagus cuniculus)	PK_Tyr_Ser-Thr Pkinase	7JUR_C_QOMC402	Details
7m0u	QO7	Binimetinib (DB11967)	Binimetinib is a medication used to treat metastatic melanoma with specific mutations.	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens)	Pkinase	7M0U_B_QO7B501	Details
PDB	Ligand	Drug	Indication	Macromolecule/ Organism	Pfam	Binding_Interfaces (View)	Details

[["4an2","EUI","Cobimetinib (DB05239)","Homo sapiens","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","Pkinase"],["4lmn","EUI","Cobimetinib (DB05239)","Homo sapiens","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","Pkinase"],["4u7z","3EW","Selumetinib (DB11689)","Homo sapiens","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","Pkinase"],["7jur","QOM","Trametinib (DB08911)","Homo sapiens;oryctolagus cuniculus","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1;KINASE SUPPRESSOR OF RAS 2","PK_Tyr_Ser-Thr;Pkinase"],["7m0u","QO7","Binimetinib (DB11967)","Homo sapiens","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","Pkinase"]]