Potential binding sites containing five residues derived from binding site similarity searches

DrReposER ID Hit Organism /
Macromolecule
Interface HETATM RMSD Dali Z-score Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2 5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2


Mus musculus
LEU A 321
LEU A 273
SER A 134
LEU A 362
GLY A 128
None
1.36A 1a4lC-5eawA:
undetectable
1a4lC-5eawA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT


Homo sapiens
HIS A 76
HIS A 158
HIS A 396
HIS A 418
ASP A 75
ZN A 481 (-3.4A)
ZN A 482 ( 3.3A)
SO4 A 491 (-4.0A)
ZN A 481 ( 3.4A)
ZN A 481 ( 2.6A)
1.20A 1e9yB-2i7tA:
undetectable
1e9yB-2i7tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT


Methanosarcina
mazei
HIS A 247
HIS A 329
HIS A 580
HIS A 604
ASP A 246
ZN A1639 (-3.3A)
ZN A1638 (-3.5A)
None
ZN A1639 (-3.3A)
ZN A1639 (-2.7A)
1.20A 1e9yB-2xr1A:
undetectable
1e9yB-2xr1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1 4mln PREDICTED HD
PHOSPHOHYDROLASE
PHNZ


uncultured
bacterium
HF130_AEPn_1
HIS A 58
HIS A 62
HIS A 80
HIS A 104
ASP A 161
FE A 201 (-3.2A)
ODV A 203 (-4.1A)
FE A 202 ( 3.4A)
FE A 202 ( 3.3A)
FE A 201 (-2.4A)
0.85A 1e9yB-4mlnA:
undetectable
1e9yB-4mlnA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1 4n6w PREDICTED HD
PHOSPHOHYDROLASE
PHNZ


uncultured
bacterium
HF130_AEPn_1
HIS A 58
HIS A 62
HIS A 80
HIS A 104
ASP A 161
FE A 202 (-3.3A)
FLC A 203 (-4.0A)
FE A 201 ( 3.4A)
FE A 201 ( 3.4A)
FE A 202 ( 2.5A)
0.89A 1e9yB-4n6wA:
undetectable
1e9yB-4n6wA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1 5a0t RIBONUCLEASE J

Streptomyces
coelicolor
HIS A 377
HIS A 84
HIS A 89
HIS A 399
ASP A 205
G E 1 ( 3.9A)
ZN A1458 (-3.6A)
ZN A1457 (-3.5A)
ZN A1457 (-3.5A)
None
1.44A 1e9yB-5a0tA:
undetectable
1e9yB-5a0tA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1 5epa SNOK

Streptomyces
nogalater
THR A 137
ASP A 123
HIS A 121
HIS A 204
HIS A 210
AKG A 301 ( 4.3A)
FE A 300 ( 2.5A)
FE A 300 ( 3.3A)
AKG A 301 (-4.4A)
FE A 300 ( 3.3A)
1.31A 1ei6A-5epaA:
undetectable
1ei6A-5epaA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1 5equ SNON,SNON

Streptomyces
nogalater
THR A 146
ASP A 132
HIS A 130
HIS A 207
HIS A 213
AKG A 301 ( 4.3A)
FE A 300 (-2.2A)
FE A 300 (-3.1A)
AKG A 301 (-4.2A)
FE A 300 ( 3.2A)
1.22A 1ei6A-5equA:
undetectable
1ei6A-5equA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3 1he9 EXOENZYME S

Pseudomonas
aeruginosa
THR A 207
LEU A 210
VAL A 213
LEU A 171
GLN A 167
None
1.46A 1fbmE-1he9A:
undetectable
1fbmE-1he9A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3 1r6a GENOME POLYPROTEIN

Dengue virus
THR A 176
LEU A 143
VAL A 78
LEU A 103
GLN A 127
None
0.92A 1fbmE-1r6aA:
undetectable
1fbmE-1r6aA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3 1zq3 HOMEOTIC BICOID
PROTEIN


Drosophila
melanogaster
THR P 28
LEU P 27
VAL P 46
LEU P 17
GLN P 13
None
1.46A 1fbmE-1zq3P:
undetectable
1fbmE-1zq3P:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3 2m0m MINOR AMPULLATE
FIBROIN 1


Nephila
antipodiana
THR A 52
LEU A 55
VAL A 58
LEU A 62
GLN A 65
None
1.22A 1fbmE-2m0mA:
undetectable
1fbmE-2m0mA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0 1q2e EXOCELLOBIOHYDROLA
SE I


Trichoderma
reesei
THR A 5
LEU A 73
GLY A 75
LYS A 166
TYR A 167
None
PCA A 1 ( 4.9A)
None
None
None
1.42A 1gtiF-1q2eA:
0.0
1gtiF-1q2eA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0 1z3v CELLULASE

Phanerochaete
chrysosporium
THR A 5
LEU A 73
GLY A 75
LYS A 163
TYR A 164
None
PCA A 1 ( 4.4A)
None
None
None
1.49A 1gtiF-1z3vA:
undetectable
1gtiF-1z3vA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0 2yok EXOGLUCANASE 1

Trichoderma
harzianum
THR A 22
LEU A 89
GLY A 91
LYS A 179
TYR A 180
None
PCA A 18 ( 4.5A)
None
None
None
1.46A 1gtiF-2yokA:
undetectable
1gtiF-2yokA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1


Symbiobacterium
toebii
ILE A 105
LEU A 106
VAL A 137
ALA A 153
CYH A 135
None
1.41A 1mz9C-3aufA:
undetectable
1mz9C-3aufA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3 3c2g SYS-1 PROTEIN

Caenorhabditis
elegans
ILE A 618
LEU A 619
VAL A 661
ALA A 717
CYH A 715
None
1.10A 1mz9C-3c2gA:
undetectable
1mz9C-3c2gA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP


Streptomyces
wadayamensis
LEU A 241
VAL A 184
CYH A 211
ALA A 175
CYH A 178
None
1.44A 1mz9D-6c9bA:
undetectable
1mz9D-6c9bA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1 1kcw CERULOPLASMIN

Homo sapiens
ASP A 576
GLU A 575
THR A 532
LEU A 572
LEU A 573
None
1.07A 1u18B-1kcwA:
undetectable
1u18B-1kcwA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1 4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12


Thermus
thermophilus
ASP L 386
GLU L 490
THR L 392
LEU L 393
LEU L 389
None
1.23A 1u18B-4heaL:
undetectable
1u18B-4heaL:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1 5gin C/D BOX
METHYLATION GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT
FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFE
RASE


Sulfolobus
solfataricus
ALA E 167
TYR A 86
ALA E 163
TYR E 165
GLN E 138
None
1.48A 1xl6A-5ginE:
undetectable
1xl6B-5ginE:
undetectable
1xl6A-5ginE:
21.04
1xl6B-5ginE:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2 1cc1 HYDROGENASE (LARGE
SUBUNIT)


Desulfomicrobium
baculatum
PRO L 479
VAL L 473
ASN L 481
VAL L 37
ILE L 14
None
1.49A 1z2bC-1cc1L:
undetectable
1z2bC-1cc1L:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2 1kug METALLOPROTEINASE

Protobothrops
mucrosquamatus
ILE A 14
ILE A 199
ILE A 42
MET A 142
LEU A 89
None
1.40A 1zgyA-1kugA:
undetectable
1zgyA-1kugA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2 1wni TRIMERELYSIN II

Protobothrops
flavoviridis
ILE A 12
ILE A 197
ILE A 40
MET A 140
LEU A 87
None
1.26A 1zgyA-1wniA:
undetectable
1zgyA-1wniA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2 3ayx MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT


Hydrogenovibrio
marinus
ILE B 153
ILE B 16
ILE B 169
MET B 172
LEU B 144
None
1.40A 1zgyA-3ayxB:
undetectable
1zgyA-3ayxB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2 5egn ESTERASE

uncultured
bacterium
ILE A 34
ILE A 237
ILE A 161
MET A 165
LEU A 114
None
1.32A 1zgyA-5egnA:
undetectable
1zgyA-5egnA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1 2pby GLUTAMINASE

Geobacillus
kaustophilus
LEU A 290
ASP A 284
GLY A 261
PRO A 281
ALA A 282
None
1.36A 2aohA-2pbyA:
undetectable
2aohA-2pbyA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2 1lgf P450 MONOOXYGENASE

Amycolatopsis
orientalis
LEU A 195
ASP A 223
GLY A 218
ALA A 199
ILE A 198
None
1.34A 2aohB-1lgfA:
undetectable
2aohB-1lgfA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2 1ufb TT1696 PROTEIN

Thermus
thermophilus
LEU A 82
ASP A 83
GLY A 55
ALA A 38
ILE A 58
None
1.35A 2aohB-1ufbA:
undetectable
2aohB-1ufbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2 1wol 122AA LONG
CONSERVED
HYPOTHETICAL
PROTEIN


Sulfurisphaera
tokodaii
LEU A 76
ASP A 77
GLY A 55
ALA A 38
ILE A 58
None
1.43A 2aohB-1wolA:
undetectable
2aohB-1wolA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2 3cgg SAM-DEPENDENT
METHYLTRANSFERASE


Corynebacterium
glutamicum
LEU A 63
ASP A 51
GLY A 145
ALA A 36
ILE A 59
None
1.48A 2aohB-3cggA:
undetectable
2aohB-3cggA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2 3fna POSSIBLE ARABINOSE
5-PHOSPHATE
ISOMERASE


Escherichia coli
LEU A 329
ASP A 328
GLY A 322
ALA A 297
ILE A 216
None
1.40A 2aohB-3fnaA:
undetectable
2aohB-3fnaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2 3pqs TRANSFERRIN-BINDIN
G PROTEIN


Actinobacillus
pleuropneumoniae
LEU A 87
ASP A 125
GLY A 122
ALA A 91
ILE A 90
None
1.19A 2aohB-3pqsA:
undetectable
2aohB-3pqsA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2 3gs9 PROTEIN GP18

Listeria
monocytogenes
LEU A 157
ASP A 154
PRO A 166
VAL A 164
ILE A 153
None
1.35A 2aoiB-3gs9A:
undetectable
2aoiB-3gs9A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1 3hxj PYRROLO-QUINOLINE
QUINONE


Methanococcus
maripaludis
LEU A 35
ASP A 303
GLY A 263
PRO A 300
VAL A 301
None
1.40A 2aojA-3hxjA:
undetectable
2aojA-3hxjA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1 1u02 TREHALOSE-6-PHOSPH
ATE PHOSPHATASE
RELATED PROTEIN


Thermoplasma
acidophilum
LEU A 35
ILE A 4
LEU A 3
SER A 2
ARG A 172
None
1.42A 2byoA-1u02A:
0.0
2byoA-1u02A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1 2vug PAB1020

Pyrococcus abyssi
LEU A 77
ILE A 218
LEU A 221
SER A 222
ARG A 226
None
1.44A 2byoA-2vugA:
undetectable
2byoA-2vugA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1 5gn5 GLYCEROL KINASE

Trypanosoma
brucei
LEU A 429
ILE A 432
LEU A 436
SER A 435
ARG A 493
None
1.48A 2byoA-5gn5A:
undetectable
2byoA-5gn5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1 5jpe SERINE/THREONINE-P
ROTEIN PHOSPHATASE


Candida albicans
LEU A 366
ILE A 326
LEU A 217
SER A 216
ARG A 352
None
1.35A 2byoA-5jpeA:
undetectable
2byoA-5jpeA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0 5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849


Brucella abortus
TYR A 235
ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.37A 2eimW-5uc2A:
undetectable
2eimW-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1 1cbk PROTEIN
(7,8-DIHYDRO-6-HYD
ROXYMETHYLPTERIN-P
YROPHOSPHOKINASE)


Haemophilus
influenzae
LEU A 94
LEU A 23
ILE A 26
ILE A 6
ALA A 7
None
1.15A 2i2zA-1cbkA:
undetectable
2i2zA-1cbkA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1 1w55 ISPD/ISPF
BIFUNCTIONAL
ENZYME


Campylobacter
jejuni
LEU A 286
LEU A 300
ILE A 303
ILE A 336
ALA A 326
None
0.88A 2i2zA-1w55A:
undetectable
2i2zA-1w55A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1 3g77 CYTOSINE DEAMINASE

Escherichia coli
LEU A 13
LEU A 376
ILE A 22
ILE A 29
ALA A 369
None
1.33A 2i2zA-3g77A:
undetectable
2i2zA-3g77A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1 4v0p MELANOMA-ASSOCIATE
D ANTIGEN 3


Homo sapiens
LEU A 256
LEU A 225
ILE A 221
ILE A 208
ALA A 207
None
0.93A 2i2zA-4v0pA:
undetectable
2i2zA-4v0pA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1 5fjj BETA-GLUCOSIDASE

Aspergillus
oryzae
LEU A 410
LEU A 501
ILE A 548
ILE A 583
ALA A 584
None
0.95A 2i2zA-5fjjA:
undetectable
2i2zA-5fjjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0 2ydy METHIONINE
ADENOSYLTRANSFERAS
E 2 SUBUNIT BETA


Homo sapiens
PRO A 221
PRO A 310
ILE A 313
GLY A 314
TYR A 186
None
1.48A 2jkjD-2ydyA:
undetectable
2jkjD-2ydyA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0 5iz1 FRUCTOSE-1,6-BISPH
OSPHATASE


Physcomitrella
patens
PRO A 248
PRO A 376
ILE A 214
GLY A 216
TYR A 218
None
1.45A 2jkjD-5iz1A:
undetectable
2jkjD-5iz1A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0 2ydy METHIONINE
ADENOSYLTRANSFERAS
E 2 SUBUNIT BETA


Homo sapiens
PRO A 221
PRO A 310
ILE A 313
GLY A 314
TYR A 186
None
1.49A 2jkjF-2ydyA:
undetectable
2jkjF-2ydyA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0 5iz1 FRUCTOSE-1,6-BISPH
OSPHATASE


Physcomitrella
patens
PRO A 248
PRO A 376
ILE A 214
GLY A 216
TYR A 218
None
1.44A 2jkjF-5iz1A:
undetectable
2jkjF-5iz1A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0 4xxw PROTOCADHERIN-15

Mus musculus
PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
None
1.36A 2m56A-4xxwB:
undetectable
2m56A-4xxwB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4 4o99 ACETYL-COA
ACETYLTRANSFERASE


Cupriavidus
necator
ALA A 353
ALA A 10
ALA A 37
GLN A 115
VAL A 111
None
1.41A 2nyrB-4o99A:
undetectable
2nyrB-4o99A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1 4fln PROTEASE DO-LIKE
2, CHLOROPLASTIC


Arabidopsis
thaliana
PRO A 424
ALA A 401
ASP A 188
ASP A 190
ASP A 310
None
1.26A 2nyuB-4flnA:
undetectable
2nyuB-4flnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2 2dkk CYTOCHROME P450

Streptomyces
coelicolor
LEU A 403
VAL A 160
LEU A 361
MET A 256
ARG A 126
None
None
HEM A 430 (-4.7A)
None
None
1.46A 2oiqA-2dkkA:
undetectable
2oiqA-2dkkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0 4l9z MALYL-COA LYASE

Rhodobacter
sphaeroides
ILE A 124
LEU A 93
ASP A 118
ALA A 123
PHE A 136
None
1.45A 2opxA-4l9zA:
undetectable
2opxA-4l9zA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1 1mbq TRYPSIN

Oncorhynchus keta
LEU A 155
ILE A 73
SER A 32
GLY A 43
HIS A 29
None
1.08A 2otfA-1mbqA:
undetectable
2otfA-1mbqA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1 2eek TRYPSIN-1

Gadus morhua
LEU A 155
ILE A 73
SER A 32
GLY A 43
HIS A 29
None
1.08A 2otfA-2eekA:
undetectable
2otfA-2eekA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0 1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)


Aspergillus
nidulans
LEU A 10
GLY A 151
PRO A 170
ILE A 173
ILE A 9
None
1.35A 2q9rA-1dqsA:
0.5
2q9rA-1dqsA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0 2pm9 PROTEIN TRANSPORT
PROTEIN SEC31


Saccharomyces
cerevisiae
LEU A 252
GLY A 255
PRO A 235
ILE A 260
ILE A 237
None
1.14A 2q9rA-2pm9A:
undetectable
2q9rA-2pm9A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0 3js3 3-DEHYDROQUINATE
DEHYDRATASE


Clostridioides
difficile
LEU A 224
GLY A 13
PRO A 200
ILE A 201
ILE A 202
None
1.37A 2q9rA-3js3A:
undetectable
2q9rA-3js3A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0 4bzk PROTEIN TRANSPORT
PROTEIN SEC31


Saccharomyces
cerevisiae
LEU A 252
GLY A 255
PRO A 235
ILE A 260
ILE A 237
None
1.15A 2q9rA-4bzkA:
undetectable
2q9rA-4bzkA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0 4fp9 MTERF
DOMAIN-CONTAINING
PROTEIN 2


Homo sapiens
LEU B 99
GLY B 103
PRO B 138
ILE B 132
ILE B 128
None
1.42A 2q9rA-4fp9B:
undetectable
2q9rA-4fp9B:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0 5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN


Klebsiella
pneumoniae
LEU A 93
GLY A 91
PRO A 115
ILE A 287
ILE A 117
None
1.24A 2q9rA-5hsgA:
undetectable
2q9rA-5hsgA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0 5ncc FATTY ACID
PHOTODECARBOXYLASE


Chlorella
variabilis
LEU A 516
GLY A 514
PRO A 513
ILE A 155
ILE A 571
None
1.34A 2q9rA-5nccA:
undetectable
2q9rA-5nccA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0 6fv4 N-ACETYLGLUCOSAMIN
E-6-PHOSPHATE
DEACETYLASE


Mycolicibacterium
smegmatis
LEU A 171
GLY A 169
PRO A 142
ILE A 163
ILE A 174
None
1.43A 2q9rA-6fv4A:
undetectable
2q9rA-6fv4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0 4dbh 2-HYDROXYHEPTA-2,4
-DIENE-1,7-DIOATE
ISOMERASE


Corynebacterium
glutamicum
GLU A 254
PRO A 256
ILE A 255
GLY A 259
LYS A 191
None
1.48A 2qeuA-4dbhA:
undetectable
2qeuC-4dbhA:
undetectable
2qeuA-4dbhA:
22.87
2qeuC-4dbhA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0 1zpu IRON TRANSPORT
MULTICOPPER
OXIDASE FET3


Saccharomyces
cerevisiae
HIS A 81
HIS A 128
HIS A 126
VAL A 96
HIS A 418
CU1 A1004 (-3.3A)
CU1 A1002 (-3.3A)
CU1 A1003 (-3.2A)
None
CU1 A1002 ( 3.3A)
0.99A 2wkoF-1zpuA:
undetectable
2wkoF-1zpuA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1 2mpe BPSL1050

Burkholderia
pseudomallei
VAL A 37
VAL A 38
THR A 15
THR A 35
ARG A 50
None
1.46A 3bjwA-2mpeA:
undetectable
3bjwA-2mpeA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2 5my0 FATTY ACID
SYNTHASE


Mus musculus
VAL B 532
VAL B 527
GLN B 596
PHE B 553
ARG B 522
None
1.50A 3bjwB-5my0B:
undetectable
3bjwB-5my0B:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1 5jju UNCHARACTERIZED
PROTEIN RV2837C


Mycobacterium
tuberculosis
HIS A 132
HIS A 312
ASP A 106
HIS A 131
ASP A 47
A C1004 ( 3.5A)
A C1004 ( 3.7A)
MN A1001 ( 2.6A)
MN A1001 (-3.5A)
MN A1001 (-3.2A)
1.49A 3c0zA-5jjuA:
undetectable
3c0zA-5jjuA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1 2c6w PENICILLIN-BINDING
PROTEIN 1A


Streptococcus
pneumoniae
ASN B 365
ALA B 347
LEU B 327
GLY B 598
THR B 371
None
1.26A 3dl9A-2c6wB:
undetectable
3dl9A-2c6wB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1 5a2o NITRATE
TRANSPORTER 1.1


Arabidopsis
thaliana
ASN A 198
ALA A 385
LEU A 470
GLY A 391
THR A 481
None
1.39A 3dl9A-5a2oA:
undetectable
3dl9A-5a2oA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1 5zvs VP2

Aquareovirus C
ASN 2 358
ALA 2 284
LEU 2 341
GLY 2 350
THR 2 253
None
1.32A 3dl9A-5zvs2:
undetectable
3dl9A-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2 2pff FATTY ACID
SYNTHASE SUBUNIT
ALPHA


Saccharomyces
cerevisiae
ASP A1391
ARG A1017
ILE A1319
VAL A1404
THR A1528
None
1.46A 3eigA-2pffA:
undetectable
3eigA-2pffA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0 3hut PUTATIVE
BRANCHED-CHAIN
AMINO ACID ABC
TRANSPORTER


Rhodospirillum
rubrum
PRO A 311
VAL A 300
THR A 358
GLY A 356
LYS A 369
None
1.46A 3elzB-3hutA:
undetectable
3elzB-3hutA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1 3aty PROSTAGLANDIN F2A
SYNTHASE


Trypanosoma cruzi
SER A 210
ARG A 207
ARG A 249
GLY A 196
GLU A 193
None
None
FMN A 500 (-2.9A)
None
None
1.50A 3k9fA-3atyA:
undetectable
3k9fB-3atyA:
undetectable
3k9fC-3atyA:
undetectable
3k9fA-3atyA:
22.64
3k9fB-3atyA:
22.64
3k9fC-3atyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1 2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE


Bacillus subtilis
LEU A 58
HIS A 137
GLU A 82
HIS A 71
HIS A 69
None
ZN A1173 (-3.4A)
ZN A1173 (-2.6A)
ZN A1173 (-3.4A)
ZN A1173 (-3.6A)
1.02A 3kecA-2y0oA:
undetectable
3kecA-2y0oA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1 5xne -

-
LEU B 31
HIS B 204
GLU B 251
HIS B 191
HIS B 193
None
ZN B 301 (-3.3A)
ZN B 301 ( 4.5A)
ZN B 301 (-3.5A)
ZN B 301 (-3.4A)
1.46A 3kecA-5xneB:
undetectable
3kecA-5xneB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2 6eoj PROTEIN CFT1

Saccharomyces
cerevisiae
VAL A 672
PHE A 734
ILE A 679
PHE A 732
PHE A 744
None
1.46A 3owxB-6eojA:
undetectable
3owxB-6eojA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0 2o36 THIMET
OLIGOPEPTIDASE


Homo sapiens
SER A 461
GLU A 467
LEU A 463
GLN A 464
LYS A 357
None
1.01A 3pgyB-2o36A:
0.0
3pgyB-2o36A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0 3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2


Schizosaccharomyc
es pombe
PHE B 387
ILE B 619
GLY B 506
CYH B 509
HIS B 504
None
1.30A 3r0lD-3h0gB:
undetectable
3r0lD-3h0gB:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0 3gdw SIGMA-54
INTERACTION DOMAIN
PROTEIN


Enterococcus
faecalis
LEU A 622
LEU A 602
GLY A 546
GLY A 605
THR A 630
None
1.29A 3si7C-3gdwA:
undetectable
3si7D-3gdwA:
undetectable
3si7C-3gdwA:
21.38
3si7D-3gdwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2 3lft UNCHARACTERIZED
PROTEIN


Streptococcus
pneumoniae
ILE A 282
PRO A 166
SER A 317
LYS A 316
GLY A 315
None
1.32A 3tkdB-3lftA:
undetectable
3tkdB-3lftA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1 1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)


Proteus vulgaris
HIS A 246
SER A 276
THR A 278
GLU A 294
ASP A 34
SAH A 401 (-4.0A)
SAH A 401 (-2.7A)
SAH A 401 (-4.0A)
SAH A 401 (-2.9A)
SAH A 401 (-4.0A)
0.49A 3tm4A-1booA:
undetectable
3tm4A-1booA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1 6eoj POLYADENYLATION
FACTOR SUBUNIT
2,POLYADENYLATION
FACTOR SUBUNIT 2
PROTEIN CFT1


Saccharomyces
cerevisiae
ASN D 69
ALA D 70
PRO D 67
TYR D 43
ALA A1143
None
1.37A 3twpD-6eojD:
undetectable
3twpD-6eojD:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1 3psg PEPSINOGEN

Sus scrofa
TYR A 9
SER A 36
ASP A 215
ASP A 303
ILE A 306
None
1.42A 3uj7B-3psgA:
undetectable
3uj7B-3psgA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY


Desulfovibrio
alaskensis
LEU A 313
GLY A 320
THR A 290
ILE A 170
VAL A 169
None
1.40A 3wriA-2rb7A:
undetectable
3wriA-2rb7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0 3e0x LIPASE-ESTERASE
RELATED PROTEIN


Clostridium
acetobutylicum
LEU A 96
GLY A 115
THR A 199
ILE A 191
VAL A 192
None
1.33A 3wriA-3e0xA:
undetectable
3wriA-3e0xA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0 2rb7 PEPTIDASE,
M20/M25/M40 FAMILY


Desulfovibrio
alaskensis
LEU A 313
GLY A 320
THR A 290
ILE A 170
VAL A 169
None
1.39A 3wriB-2rb7A:
undetectable
3wriB-2rb7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0 3e0x LIPASE-ESTERASE
RELATED PROTEIN


Clostridium
acetobutylicum
LEU A 96
GLY A 115
THR A 199
ILE A 191
VAL A 192
None
1.33A 3wriB-3e0xA:
undetectable
3wriB-3e0xA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0 2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRAN
SFERASE


Mycobacterium
tuberculosis
PHE A 415
LEU A 395
GLY A 394
ILE A 405
VAL A 402
None
1.33A 3wrkA-2o0xA:
undetectable
3wrkA-2o0xA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0 3ui7 CAMP AND
CAMP-INHIBITED
CGMP 3',5'-CYCLIC
PHOSPHODIESTERASE
10A


Homo sapiens
PHE A 477
LEU A 464
GLY A 488
ILE A 479
VAL A 531
None
1.45A 3wrkA-3ui7A:
undetectable
3wrkA-3ui7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0 4rvh D-MYCAROSE
3-C-METHYLTRANSFER
ASE


Streptomyces
argillaceus
PHE A 180
LEU A 61
GLY A 231
ILE A 205
VAL A 261
None
1.37A 3wrkA-4rvhA:
undetectable
3wrkA-4rvhA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0 6cgs CADHERIN-7

Mus musculus
PHE A 155
LEU A 205
GLY A 114
ILE A 164
VAL A 126
None
1.29A 3wrkA-6cgsA:
undetectable
3wrkA-6cgsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0 1efy POLY (ADP-RIBOSE)
POLYMERASE


Gallus gallus
HIS A 862
GLY A 863
TYR A 896
TYR A 907
GLU A 988
BZC A 201 (-4.0A)
BZC A 201 (-3.9A)
BZC A 201 (-4.0A)
BZC A 201 (-3.6A)
BZC A 201 (-4.0A)
0.46A 4ae1B-1efyA:
0.1
4ae1B-1efyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0 1lla HEMOCYANIN
(SUBUNIT TYPE II)


Limulus
polyphemus
HIS A 364
HIS A 324
HIS A 173
HIS A 204
HIS A 177
CU A 630 (-3.0A)
CU A 630 (-3.3A)
CU A 629 (-3.2A)
CU A 629 (-3.1A)
CU A 629 (-3.2A)
1.38A 4ef3A-1llaA:
undetectable
4ef3A-1llaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0 4bed HEMOCYANIN KLH1

Megathura
crenulata
HIS B3106
HIS B3075
HIS B2946
HIS B2974
HIS B2965
CUO B9008 (-3.3A)
CUO B9008 (-2.8A)
CUO B9008 (-3.1A)
CUO B9008 (-2.9A)
CUO B9008 (-3.2A)
1.30A 4ef3A-4bedB:
undetectable
4ef3A-4bedB:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0 4i7h PEROXIDE STRESS
SENSING REGULATOR


Streptococcus
pyogenes
HIS A 6
HIS A 99
HIS A 19
HIS A 4
HIS A 97
NI A 201 (-3.6A)
NI A 201 (-3.5A)
NI A 201 (-3.5A)
NI A 201 (-3.6A)
NI A 201 (-3.6A)
1.29A 4ef3A-4i7hA:
undetectable
4ef3A-4i7hA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0 4ymk ACYL-COA
DESATURASE 1


Mus musculus
HIS A 157
HIS A 156
HIS A 297
HIS A 298
HIS A 294
ZN A 401 (-3.3A)
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 402 (-3.4A)
ZN A 402 (-3.1A)
1.22A 4ef3A-4ymkA:
undetectable
4ef3A-4ymkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0 4ymk ACYL-COA
DESATURASE 1


Mus musculus
HIS A 298
HIS A 297
HIS A 156
HIS A 157
HIS A 153
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 402 (-3.4A)
ZN A 401 (-3.3A)
ZN A 401 ( 3.2A)
1.10A 4ef3A-4ymkA:
undetectable
4ef3A-4ymkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0 4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 272
HIS A 271
HIS A 345
HIS A 349
HIS A 330
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 401 (-3.5A)
ZN A 401 (-3.2A)
ZN A 401 (-3.3A)
1.26A 4ef3A-4zr0A:
undetectable
4ef3A-4zr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0 4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
ZN A 401 (-3.5A)
1.19A 4ef3A-4zr0A:
undetectable
4ef3A-4zr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0 4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
ZN A 402 (-3.4A)
ZN A 402 (-3.5A)
1.25A 4ef3A-4zr0A:
undetectable
4ef3A-4zr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 244
HIS A 249
HIS A 349
HIS A 348
HIS A 272
ZN A 402 (-3.5A)
ZN A 402 (-3.2A)
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 402 (-3.5A)
1.25A 4ef3A-4zr1A:
undetectable
4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 244
HIS A 268
HIS A 345
HIS A 348
HIS A 349
ZN A 402 (-3.5A)
ZN A 402 (-3.3A)
ZN A 401 (-3.4A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
1.39A 4ef3A-4zr1A:
undetectable
4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
ZN A 402 (-3.5A)
ZN A 401 ( 3.4A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
ZN A 401 (-3.4A)
1.25A 4ef3A-4zr1A:
undetectable
4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 401 ( 3.4A)
ZN A 402 (-3.5A)
ZN A 402 (-3.3A)
1.28A 4ef3A-4zr1A:
undetectable
4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0 4zyo ACYL-COA
DESATURASE


Homo sapiens
HIS A 302
HIS A 301
HIS A 160
HIS A 161
HIS A 157
ZN A 402 (-3.5A)
ZN A 401 (-3.4A)
ZN A 402 (-3.2A)
ZN A 401 (-3.3A)
ZN A 401 ( 3.2A)
1.25A 4ef3A-4zyoA:
undetectable
4ef3A-4zyoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36


Canis lupus
PHE A 118
PHE A 206
ILE A 133
GLY A 132
THR A 163
None
1.30A 4ejjC-2dupA:
undetectable
4ejjC-2dupA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1 3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLY
ZING]


Coxiella burnetii
PHE A 122
PHE A 180
ILE A 193
GLY A 190
THR A 187
None
1.35A 4ejjC-3tqiA:
undetectable
4ejjC-3tqiA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1 4v2x ENDO-BETA-1,4-GLUC
ANASE (CELLULASE
B)


Bacillus
halodurans
PHE A 527
PHE A 472
ILE A 551
GLY A 560
THR A 465
None
1.44A 4ejjC-4v2xA:
undetectable
4ejjC-4v2xA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT


Homo sapiens
HIS A 76
HIS A 158
HIS A 396
HIS A 418
ASP A 75
ZN A 481 (-3.4A)
ZN A 482 ( 3.3A)
SO4 A 491 (-4.0A)
ZN A 481 ( 3.4A)
ZN A 481 ( 2.6A)
1.17A 4h9mA-2i7tA:
undetectable
4h9mA-2i7tA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1 2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT


Methanosarcina
mazei
HIS A 247
HIS A 329
HIS A 580
HIS A 604
ASP A 246
ZN A1639 (-3.3A)
ZN A1638 (-3.5A)
None
ZN A1639 (-3.3A)
ZN A1639 (-2.7A)
1.18A 4h9mA-2xr1A:
undetectable
4h9mA-2xr1A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1 3zq4 RIBONUCLEASE J 1

Bacillus subtilis
HIS A 368
HIS A 74
HIS A 79
HIS A 390
ASP A 195
None
ZN A1557 (-3.0A)
ZN A1556 (-3.2A)
ZN A1556 (-3.4A)
None
1.46A 4h9mA-3zq4A:
undetectable
4h9mA-3zq4A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1 4mln PREDICTED HD
PHOSPHOHYDROLASE
PHNZ


uncultured
bacterium
HF130_AEPn_1
HIS A 58
HIS A 62
HIS A 80
HIS A 104
ASP A 161
FE A 201 (-3.2A)
ODV A 203 (-4.1A)
FE A 202 ( 3.4A)
FE A 202 ( 3.3A)
FE A 201 (-2.4A)
0.90A 4h9mA-4mlnA:
undetectable
4h9mA-4mlnA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1 4n6w PREDICTED HD
PHOSPHOHYDROLASE
PHNZ


uncultured
bacterium
HF130_AEPn_1
HIS A 58
HIS A 62
HIS A 80
HIS A 104
ASP A 161
FE A 202 (-3.3A)
FLC A 203 (-4.0A)
FE A 201 ( 3.4A)
FE A 201 ( 3.4A)
FE A 202 ( 2.5A)
0.93A 4h9mA-4n6wA:
undetectable
4h9mA-4n6wA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1 4xwt DR2417

Deinococcus
radiodurans
HIS A 381
HIS A 84
HIS A 89
HIS A 403
ASP A 209
U5P A 606 (-3.9A)
ZN A 601 (-3.5A)
ZN A 602 (-3.3A)
ZN A 602 (-3.2A)
None
1.35A 4h9mA-4xwtA:
undetectable
4h9mA-4xwtA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1 5a0t RIBONUCLEASE J

Streptomyces
coelicolor
HIS A 377
HIS A 84
HIS A 89
HIS A 399
ASP A 205
G E 1 ( 3.9A)
ZN A1458 (-3.6A)
ZN A1457 (-3.5A)
ZN A1457 (-3.5A)
None
1.41A 4h9mA-5a0tA:
undetectable
4h9mA-5a0tA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0 2fvm DIHYDROPYRIMIDINAS
E


Lachancea
kluyveri
GLU A 201
SER A 258
ARG A 228
PRO A 332
SER A 257
None
1.41A 4k17B-2fvmA:
undetectable
4k17B-2fvmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0 4qfv ANK-N5C-281

synthetic
construct
LYS A 88
LEU A 89
GLU A 85
LEU A 51
LYS A 55
None
1.44A 4k4yA-4qfvA:
undetectable
4k4yA-4qfvA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0 4qfv ANK-N5C-281

synthetic
construct
LYS A 88
LEU A 89
GLU A 85
LEU A 51
LYS A 55
None
1.46A 4k4yI-4qfvA:
undetectable
4k4yI-4qfvA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0 4xxw PROTOCADHERIN-15

Mus musculus
PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
None
1.35A 4l49A-4xxwB:
undetectable
4l49A-4xxwB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0 1sf8 CHAPERONE PROTEIN
HTPG


Escherichia coli
GLU A 594
VAL A 593
LEU A 519
VAL A 523
PHE A 568
None
1.37A 4lb0B-1sf8A:
undetectable
4lb0B-1sf8A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0 5kxf FLOWERING TIME
CONTROL PROTEIN
FPA


Arabidopsis
thaliana
GLU A 465
VAL A 496
LEU A 468
VAL A 472
PHE A 498
None
1.35A 4lb0B-5kxfA:
undetectable
4lb0B-5kxfA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0 2w38 SIALIDASE

Pseudomonas
aeruginosa
GLY A 296
SER A 295
ALA A 294
PHE A 313
GLU A 315
None
1.24A 4m93B-2w38A:
undetectable
4m93C-2w38A:
2.1
4m93B-2w38A:
20.45
4m93C-2w38A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0 3id3 REGULATOR OF SIGMA
E PROTEASE


Escherichia coli
GLY A 303
SER A 233
ALA A 234
PHE A 301
GLU A 290
None
1.33A 4m93B-3id3A:
undetectable
4m93C-3id3A:
undetectable
4m93B-3id3A:
18.06
4m93C-3id3A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0 2pr7 HALOACID
DEHALOGENASE/EPOXI
DE HYDROLASE
FAMILY


Corynebacterium
glutamicum
VAL A 63
LEU A 65
ILE A 51
LEU A 54
ARG A 52
None
None
None
EDO A 138 ( 4.8A)
None
1.31A 4mghA-2pr7A:
undetectable
4mghA-2pr7A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0 5hzr SNF2-FAMILY ATP
DEPENDENT
CHROMATIN
REMODELING FACTOR
LIKE PROTEIN


Thermothelomyces
thermophila
VAL A 797
LEU A1008
ILE A 998
LEU A 997
ARG A 996
None
1.24A 4mghA-5hzrA:
undetectable
4mghA-5hzrA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0 5ve3 BPPRF

Paraburkholderia
phytofirmans
VAL B 271
LEU B 304
ILE B 292
LEU B 291
ARG B 290
None
1.16A 4mghA-5ve3B:
undetectable
4mghA-5ve3B:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1 3dwo PROBABLE OUTER
MEMBRANE PROTEIN


Pseudomonas
aeruginosa
ASN X 9
ALA X 11
GLY X 12
ASP X 226
ASP X 344
None
1.22A 4n48A-3dwoX:
undetectable
4n48A-3dwoX:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2 2vdu TRNA
(GUANINE-N(7)-)-ME
THYLTRANSFERASE-AS
SOCIATED WD REPEAT
PROTEIN TRM82


Saccharomyces
cerevisiae
ILE B 306
LEU B 288
ASP B 262
GLU B 307
VAL B 433
None
1.30A 4nkxB-2vduB:
undetectable
4nkxB-2vduB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2 1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT
[NIFE] HYDROGENASE
SMALL SUBUNIT


Desulfovibrio
desulfuricans
GLY B 174
LEU B 124
ILE A 48
LEU B 206
LEU B 133
None
1.47A 4o8fA-1e3dB:
0.0
4o8fA-1e3dB:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2 1txg GLYCEROL-3-PHOSPHA
TE DEHYDROGENASE
[NAD(P)+]


Archaeoglobus
fulgidus
GLY A 83
LEU A 102
ILE A 108
LEU A 124
LEU A 65
None
1.35A 4o8fA-1txgA:
undetectable
4o8fA-1txgA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2 2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)


Arabidopsis
thaliana
GLY A 149
LEU A 98
ILE A 89
LEU A 31
LEU A 183
None
1.37A 4o8fA-2wtbA:
undetectable
4o8fA-2wtbA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0 3wz0 RIBONUCLEASE P
PROTEIN COMPONENT
2


Thermococcus
kodakarensis
SER C 93
GLY C 92
ARG C 27
GLU C 33
PHE C 29
None
1.43A 4r82A-3wz0C:
undetectable
4r82B-3wz0C:
undetectable
4r82A-3wz0C:
23.24
4r82B-3wz0C:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2 1xtz RIBOSE-5-PHOSPHATE
ISOMERASE


Saccharomyces
cerevisiae
ILE A 102
VAL A 132
PHE A 80
CYH A 75
HIS A 39
None
1.48A 4rzvA-1xtzA:
undetectable
4rzvA-1xtzA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0 3g7t ENVELOPE PROTEIN

Dengue virus
ILE A 43
VAL A 23
ILE A 6
VAL A 31
THR A 33
None
1.25A 4xdtA-3g7tA:
undetectable
4xdtA-3g7tA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0 3o8l 6-PHOSPHOFRUCTOKIN
ASE, MUSCLE TYPE


Oryctolagus
cuniculus
ILE A 116
VAL A 20
ILE A 84
VAL A 34
THR A 82
None
1.48A 4xdtA-3o8lA:
undetectable
4xdtA-3o8lA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0 3v2b POLY [ADP-RIBOSE]
POLYMERASE 15


Homo sapiens
ILE A 354
VAL A 300
ILE A 386
VAL A 369
THR A 365
None
1.19A 4xdtA-3v2bA:
undetectable
4xdtA-3v2bA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0 4m0k ADENINE
PHOSPHORIBOSYLTRAN
SFERASE


Rhodothermus
marinus
ILE A 114
VAL A 120
ILE A 122
VAL A 140
THR A 136
None
1.05A 4xdtA-4m0kA:
undetectable
4xdtA-4m0kA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0 4rgd BACTERIOCIN AS-48

Enterococcus
faecalis
ILE A 7
VAL A 35
ILE A 31
VAL A 11
THR A 14
None
1.40A 4xdtA-4rgdA:
undetectable
4xdtA-4rgdA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1 1xdi RV3303C-LPDA

Mycobacterium
tuberculosis
LEU A 8
ALA A 314
THR A 307
VAL A 289
ILE A 291
FAD A 999 ( 4.8A)
None
None
None
None
1.10A 4xe3A-1xdiA:
undetectable
4xe3A-1xdiA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1 4bej DYNAMIN 1-LIKE
PROTEIN


Homo sapiens
LEU A 67
ALA A 286
THR A 282
VAL A 258
ILE A 262
None
1.11A 4xe3A-4bejA:
undetectable
4xe3A-4bejA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1 1u2v ARP2/3 COMPLEX
16KDA SUBUNIT
ARP2/3 COMPLEX
20KDA SUBUNIT


Bos taurus
LEU G 125
ALA F 11
THR F 15
VAL G 144
ILE G 141
None
1.00A 4xe3B-1u2vG:
undetectable
4xe3B-1u2vG:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1 2raf PUTATIVE
DINUCLEOTIDE-BINDI
NG OXIDOREDUCTASE


Lactobacillus
plantarum
LEU A 98
ALA A 91
THR A 71
VAL A 46
ILE A 70
None
None
NAP A 200 ( 4.2A)
NAP A 200 ( 4.1A)
NAP A 200 ( 4.3A)
1.40A 4xe3B-2rafA:
undetectable
4xe3B-2rafA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1 3tdf DIHYDRODIPICOLINAT
E SYNTHASE


Acinetobacter
baumannii
LEU A 256
ALA A 207
THR A 36
VAL A 28
ILE A 39
None
1.49A 4xe3B-3tdfA:
undetectable
4xe3B-3tdfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1 3c75 METHYLAMINE
DEHYDROGENASE
HEAVY CHAIN


Paracoccus
versutus
ARG H 340
ARG H 312
GLY H 286
GLU H 305
SER H 349
None
1.42A 4z3oA-3c75H:
undetectable
4z3oB-3c75H:
undetectable
4z3oA-3c75H:
19.95
4z3oB-3c75H:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0 2f4n HYPOTHETICAL
PROTEIN MJ1651


Methanocaldococcu
s jannaschii
ILE A 151
ILE A 125
ARG A 123
TYR A 103
GLU A 97
None
1.13A 4zzcE-2f4nA:
undetectable
4zzcE-2f4nA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1 1ufa TT1467 PROTEIN

Thermus
thermophilus
SER A 258
ARG A 387
GLY A 179
THR A 385
GLU A 138
None
1.39A 5btiA-1ufaA:
undetectable
5btiB-1ufaA:
undetectable
5btiA-1ufaA:
20.70
5btiB-1ufaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1 3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL


Homo sapiens
SER A 910
ARG A 675
GLY A 609
THR A 568
GLU A 605
None
1.36A 5btiA-3bg9A:
undetectable
5btiB-3bg9A:
undetectable
5btiA-3bg9A:
22.34
5btiB-3bg9A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1 1ufa TT1467 PROTEIN

Thermus
thermophilus
SER A 258
ARG A 387
GLY A 179
THR A 385
GLU A 138
None
1.47A 5btiC-1ufaA:
undetectable
5btiD-1ufaA:
undetectable
5btiC-1ufaA:
20.70
5btiD-1ufaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1 2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2


Homo sapiens
SER A 136
ARG A 164
GLY A 162
GLU A 160
ARG A 168
None
1.44A 5cdqR-2pvsA:
undetectable
5cdqS-2pvsA:
3.1
5cdqT-2pvsA:
undetectable
5cdqR-2pvsA:
21.04
5cdqS-2pvsA:
17.63
5cdqT-2pvsA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0 1kkh MEVALONATE KINASE

Methanocaldococcu
s jannaschii
PHE A 100
ILE A 67
GLY A 99
ILE A 85
LEU A 64
None
1.41A 5dzkB-1kkhA:
undetectable
5dzkI-1kkhA:
undetectable
5dzkW-1kkhA:
undetectable
5dzkB-1kkhA:
19.09
5dzkI-1kkhA:
22.33
5dzkW-1kkhA:
0.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0 1m93 SERINE PROTEINASE
INHIBITOR 2
SERINE PROTEINASE
INHIBITOR 2


Cowpox virus;
Cowpox virus
PHE B 77
ILE A 29
GLY A 33
ILE B 81
LEU A 30
None
1.49A 5dzkB-1m93B:
undetectable
5dzkI-1m93B:
undetectable
5dzkW-1m93B:
undetectable
5dzkB-1m93B:
23.32
5dzkI-1m93B:
22.57
5dzkW-1m93B:
0.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0 3ec7 PUTATIVE
DEHYDROGENASE


Salmonella
enterica
PHE A 125
ILE A 178
GLY A 304
ILE A 175
LEU A 306
None
1.19A 5dzkB-3ec7A:
undetectable
5dzkI-3ec7A:
1.5
5dzkW-3ec7A:
undetectable
5dzkB-3ec7A:
21.30
5dzkI-3ec7A:
20.55
5dzkW-3ec7A:
0.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0 3onq REGULATOR OF
POLYKETIDE
SYNTHASE
EXPRESSION


Bifidobacterium
adolescentis
PHE A 115
ILE A 85
GLY A 57
ILE A 71
LEU A 93
None
1.07A 5dzkB-3onqA:
undetectable
5dzkI-3onqA:
undetectable
5dzkW-3onqA:
undetectable
5dzkB-3onqA:
23.28
5dzkI-3onqA:
22.94
5dzkW-3onqA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0 3sun DNA POLYMERASE

Escherichia virus
RB69
PHE A 701
ILE A 727
GLY A 700
ILE A 749
LEU A 710
None
1.46A 5dzkB-3sunA:
undetectable
5dzkI-3sunA:
undetectable
5dzkW-3sunA:
undetectable
5dzkB-3sunA:
13.39
5dzkI-3sunA:
13.16
5dzkW-3sunA:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0 4bn7 COPPER INDUCED
NITROREDUCTASE D


Lactococcus
lactis
PHE A 179
ILE A 50
GLY A 97
ILE A 30
LEU A 51
None
1.49A 5dzkB-4bn7A:
undetectable
5dzkI-4bn7A:
undetectable
5dzkW-4bn7A:
undetectable
5dzkB-4bn7A:
22.27
5dzkI-4bn7A:
24.00
5dzkW-4bn7A:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0 4kjd INTESTINAL-TYPE
ALKALINE
PHOSPHATASE 1


Rattus norvegicus
PHE A 334
ILE A 354
GLY A 312
ILE A 338
LEU A 40
None
1.50A 5dzkB-4kjdA:
undetectable
5dzkI-4kjdA:
undetectable
5dzkW-4kjdA:
undetectable
5dzkB-4kjdA:
18.31
5dzkI-4kjdA:
17.12
5dzkW-4kjdA:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN


Sinorhizobium
meliloti
PHE A 419
ILE A 385
GLY A 418
ILE A 381
LEU A 417
None
1.44A 5dzkB-4wedA:
undetectable
5dzkI-4wedA:
undetectable
5dzkW-4wedA:
undetectable
5dzkB-4wedA:
19.31
5dzkI-4wedA:
17.39
5dzkW-4wedA:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR


Mycobacterium
tuberculosis
PHE A 179
ILE A 155
GLY A 181
ILE A 146
LEU A 157
None
1.38A 5dzkB-5d1rA:
undetectable
5dzkI-5d1rA:
undetectable
5dzkW-5d1rA:
undetectable
5dzkB-5d1rA:
24.90
5dzkI-5d1rA:
25.91
5dzkW-5d1rA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0 5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41


Homo sapiens
PHE A 226
ILE A 212
GLY A 230
ILE A 396
LEU A 233
None
1.35A 5dzkB-5gvsA:
undetectable
5dzkI-5gvsA:
undetectable
5dzkW-5gvsA:
undetectable
5dzkB-5gvsA:
22.98
5dzkI-5gvsA:
19.42
5dzkW-5gvsA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0 1kkh MEVALONATE KINASE

Methanocaldococcu
s jannaschii
PHE A 100
ILE A 67
GLY A 99
ILE A 85
LEU A 64
None
1.39A 5dzkd-1kkhA:
undetectable
5dzkk-1kkhA:
0.4
5dzky-1kkhA:
undetectable
5dzkd-1kkhA:
19.09
5dzkk-1kkhA:
22.33
5dzky-1kkhA:
0.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0 3sun DNA POLYMERASE

Escherichia virus
RB69
PHE A 701
ILE A 727
GLY A 700
ILE A 749
LEU A 710
None
1.43A 5dzkd-3sunA:
undetectable
5dzkk-3sunA:
undetectable
5dzky-3sunA:
undetectable
5dzkd-3sunA:
13.39
5dzkk-3sunA:
13.16
5dzky-3sunA:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0 5o7x RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN11


Saccharomyces
cerevisiae
PHE C 236
ILE C 247
GLY C 252
ILE C 240
LEU C 250
None
1.20A 5dzkd-5o7xC:
undetectable
5dzkk-5o7xC:
undetectable
5dzky-5o7xC:
undetectable
5dzkd-5o7xC:
17.22
5dzkk-5o7xC:
16.60
5dzky-5o7xC:
1.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2


Homo sapiens
ALA A 191
TYR A 194
PRO A 217
GLY A 101
LEU A 221
None
1.48A 5eslA-5u7qA:
undetectable
5eslA-5u7qA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2 5uyg PERIPLASMIC
CHELATED
IRON-BINDING
PROTEIN YFEA


Yersinia pestis
ALA A 179
TYR A 178
PRO A 146
GLY A 208
LEU A 297
None
0.96A 5eslA-5uygA:
undetectable
5eslA-5uygA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1 5oac MAJOR CAPSID
PROTEIN


unidentified
phage
ILE A 3
LYS A 59
ILE A 58
HIS A 57
VAL A 56
None
1.07A 5jmnA-5oacA:
1.2
5jmnA-5oacA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0 1r9j TRANSKETOLASE

Leishmania
mexicana
PRO A 35
ALA A 38
ALA A 8
ILE A 11
LEU A 70
None
1.19A 5jncD-1r9jA:
0.0
5jncD-1r9jA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0 1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT


Geobacillus
stearothermophilu
s
PRO A 39
ALA A 37
ALA A 243
ILE A 25
LEU A 26
None
1.24A 5jncD-1w85A:
undetectable
5jncD-1w85A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0 1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE
2


Homo sapiens
PRO A 297
ALA A 381
ALA A 300
ILE A 301
LEU A 335
None
1.47A 5jncD-1wl4A:
undetectable
5jncD-1wl4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0 3h0r ASPARTYL/GLUTAMYL-
TRNA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B


Aquifex aeolicus
PRO B 369
ALA B 373
ALA B 333
ILE B 343
LEU B 347
None
1.19A 5jncD-3h0rB:
undetectable
5jncD-3h0rB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0 4lrs 4-HYDROXY-2-OXOVAL
ERATE ALDOLASE


Thermomonospora
curvata
PRO A 312
ALA A 313
ALA A 306
ILE A 316
LEU A 340
None
1.47A 5jncD-4lrsA:
undetectable
5jncD-4lrsA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0 4q73 PROLINE
DEHYDROGENASE


Bradyrhizobium
diazoefficiens
PRO A 485
ALA A 368
ALA A 488
ILE A 489
LEU A 24
None
SO4 A2004 (-3.3A)
SO4 A2004 ( 4.2A)
None
None
1.42A 5jncD-4q73A:
undetectable
5jncD-4q73A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0 4rlv ANKYRIN-1,
ANKYRIN-2


Homo sapiens;
Mus musculus
PRO A2194
ALA A2195
ALA A2168
ILE A2198
LEU A1614
None
1.12A 5jncD-4rlvA:
undetectable
5jncD-4rlvA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0 4xbz EVDO1

Micromonospora
carbonacea
PRO A 96
ALA A 94
ALA A 54
ILE A 97
LEU A 100
None
1.29A 5jncD-4xbzA:
undetectable
5jncD-4xbzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1 2g3n ALPHA-GLUCOSIDASE

Sulfolobus
solfataricus
TYR A 162
ILE A 150
LEU A 67
GLY A 66
PHE A 105
None
1.35A 5kmdC-2g3nA:
undetectable
5kmdD-2g3nA:
undetectable
5kmdC-2g3nA:
18.91
5kmdD-2g3nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1 2i7g MONOOXYGENASE

Agrobacterium
fabrum
TYR A 330
ILE A 327
LEU A 287
GLY A 237
PHE A 238
None
1.43A 5kmdC-2i7gA:
undetectable
5kmdD-2i7gA:
undetectable
5kmdC-2i7gA:
20.93
5kmdD-2i7gA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1 5cgl ADENOSINE
MONOPHOSPHATE-PROT
EIN TRANSFERASE
NMFIC


Neisseria
meningitidis
TYR A 48
ILE A 45
LEU A 53
GLY A 51
PHE A 50
None
1.48A 5kmdC-5cglA:
undetectable
5kmdD-5cglA:
undetectable
5kmdC-5cglA:
19.65
5kmdD-5cglA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0 2j5a 30S RIBOSOMAL
PROTEIN S6


Aquifex aeolicus
VAL A 32
THR A 12
ASN A 97
ASP A 83
LEU A 86
None
1.46A 5m0iB-2j5aA:
undetectable
5m0iB-2j5aA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0 1hcy ARTHROPODAN
HEMOCYANIN


Panulirus
interruptus
HIS A 198
HIS A 194
HIS A 344
HIS A 224
HIS A 384
CU A 665 (-3.1A)
CU A 665 (-3.0A)
CU A 666 (-3.1A)
CU A 665 (-3.5A)
CU A 666 (-3.4A)
1.22A 5mejA-1hcyA:
undetectable
5mejA-1hcyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0 1lla HEMOCYANIN
(SUBUNIT TYPE II)


Limulus
polyphemus
HIS A 364
HIS A 324
HIS A 173
HIS A 204
HIS A 177
CU A 630 (-3.0A)
CU A 630 (-3.3A)
CU A 629 (-3.2A)
CU A 629 (-3.1A)
CU A 629 (-3.2A)
1.40A 5mejA-1llaA:
undetectable
5mejA-1llaA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0 3w6q TYROSINASE

Aspergillus
oryzae
HIS A 372
HIS A 328
HIS A 67
HIS A 103
HIS A 94
None
1.34A 5mejA-3w6qA:
undetectable
5mejA-3w6qA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE


Agaricus bisporus
HIS A 255
HIS A 251
HIS A 57
HIS A 283
HIS A 91
CU1 A 402 (-3.1A)
CU1 A 402 (-3.0A)
CU1 A 401 (-3.2A)
CU1 A 402 (-2.9A)
CU1 A 401 (-3.3A)
1.31A 5mejA-4ouaA:
undetectable
5mejA-4ouaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0 4ymk ACYL-COA
DESATURASE 1


Mus musculus
HIS A 157
HIS A 156
HIS A 297
HIS A 298
HIS A 294
ZN A 401 (-3.3A)
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 402 (-3.4A)
ZN A 402 (-3.1A)
1.13A 5mejA-4ymkA:
undetectable
5mejA-4ymkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0 4ymk ACYL-COA
DESATURASE 1


Mus musculus
HIS A 298
HIS A 297
HIS A 156
HIS A 157
HIS A 153
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 402 (-3.4A)
ZN A 401 (-3.3A)
ZN A 401 ( 3.2A)
1.01A 5mejA-4ymkA:
undetectable
5mejA-4ymkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0 4yzw AGAP004976-PA

Anopheles gambiae
HIS A 419
HIS A 379
HIS A 223
HIS A 252
HIS A 227
CU A 802 (-3.1A)
CU A 802 (-3.2A)
CU A 801 (-3.0A)
CU A 801 (-3.2A)
CU A 801 (-3.2A)
1.37A 5mejA-4yzwA:
undetectable
5mejA-4yzwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0 4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 244
HIS A 268
HIS A 345
HIS A 348
HIS A 349
ZN A 402 (-3.7A)
ZN A 402 (-3.5A)
ZN A 401 (-3.5A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
1.36A 5mejA-4zr0A:
undetectable
5mejA-4zr0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0 4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
ZN A 401 (-3.5A)
1.10A 5mejA-4zr0A:
undetectable
5mejA-4zr0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0 4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
ZN A 402 (-3.4A)
ZN A 402 (-3.5A)
1.14A 5mejA-4zr0A:
undetectable
5mejA-4zr0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 244
HIS A 268
HIS A 345
HIS A 348
HIS A 349
ZN A 402 (-3.5A)
ZN A 402 (-3.3A)
ZN A 401 (-3.4A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
1.39A 5mejA-4zr1A:
undetectable
5mejA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
ZN A 402 (-3.5A)
ZN A 401 ( 3.4A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
ZN A 401 (-3.4A)
1.15A 5mejA-4zr1A:
undetectable
5mejA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 401 ( 3.4A)
ZN A 402 (-3.5A)
ZN A 402 (-3.3A)
1.18A 5mejA-4zr1A:
undetectable
5mejA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0 4zyo ACYL-COA
DESATURASE


Homo sapiens
HIS A 302
HIS A 301
HIS A 160
HIS A 161
HIS A 157
ZN A 402 (-3.5A)
ZN A 401 (-3.4A)
ZN A 402 (-3.2A)
ZN A 401 (-3.3A)
ZN A 401 ( 3.2A)
1.17A 5mejA-4zyoA:
undetectable
5mejA-4zyoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0 1hcy ARTHROPODAN
HEMOCYANIN


Panulirus
interruptus
HIS A 198
HIS A 194
HIS A 344
HIS A 224
HIS A 384
CU A 665 (-3.1A)
CU A 665 (-3.0A)
CU A 666 (-3.1A)
CU A 665 (-3.5A)
CU A 666 (-3.4A)
1.21A 5mewA-1hcyA:
undetectable
5mewA-1hcyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0 3w6q TYROSINASE

Aspergillus
oryzae
HIS A 372
HIS A 328
HIS A 67
HIS A 103
HIS A 94
None
1.34A 5mewA-3w6qA:
undetectable
5mewA-3w6qA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0 4bed HEMOCYANIN KLH1

Megathura
crenulata
HIS B3106
HIS B3075
HIS B2946
HIS B2974
HIS B2965
CUO B9008 (-3.3A)
CUO B9008 (-2.8A)
CUO B9008 (-3.1A)
CUO B9008 (-2.9A)
CUO B9008 (-3.2A)
1.31A 5mewA-4bedB:
undetectable
5mewA-4bedB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE


Agaricus bisporus
HIS A 255
HIS A 251
HIS A 57
HIS A 283
HIS A 91
CU1 A 402 (-3.1A)
CU1 A 402 (-3.0A)
CU1 A 401 (-3.2A)
CU1 A 402 (-2.9A)
CU1 A 401 (-3.3A)
1.30A 5mewA-4ouaA:
undetectable
5mewA-4ouaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0 4ymk ACYL-COA
DESATURASE 1


Mus musculus
HIS A 157
HIS A 156
HIS A 297
HIS A 298
HIS A 294
ZN A 401 (-3.3A)
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 402 (-3.4A)
ZN A 402 (-3.1A)
1.13A 5mewA-4ymkA:
undetectable
5mewA-4ymkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0 4ymk ACYL-COA
DESATURASE 1


Mus musculus
HIS A 298
HIS A 297
HIS A 156
HIS A 157
HIS A 153
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 402 (-3.4A)
ZN A 401 (-3.3A)
ZN A 401 ( 3.2A)
1.01A 5mewA-4ymkA:
undetectable
5mewA-4ymkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0 4yzw AGAP004976-PA

Anopheles gambiae
HIS A 419
HIS A 379
HIS A 223
HIS A 252
HIS A 227
CU A 802 (-3.1A)
CU A 802 (-3.2A)
CU A 801 (-3.0A)
CU A 801 (-3.2A)
CU A 801 (-3.2A)
1.37A 5mewA-4yzwA:
undetectable
5mewA-4yzwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0 4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
ZN A 401 (-3.5A)
1.10A 5mewA-4zr0A:
undetectable
5mewA-4zr0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0 4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
ZN A 402 (-3.4A)
ZN A 402 (-3.5A)
1.14A 5mewA-4zr0A:
undetectable
5mewA-4zr0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 244
HIS A 268
HIS A 345
HIS A 348
HIS A 349
ZN A 402 (-3.5A)
ZN A 402 (-3.3A)
ZN A 401 (-3.4A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
1.38A 5mewA-4zr1A:
undetectable
5mewA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
ZN A 402 (-3.5A)
ZN A 401 ( 3.4A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
ZN A 401 (-3.4A)
1.14A 5mewA-4zr1A:
undetectable
5mewA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 401 ( 3.4A)
ZN A 402 (-3.5A)
ZN A 402 (-3.3A)
1.18A 5mewA-4zr1A:
undetectable
5mewA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0 4zyo ACYL-COA
DESATURASE


Homo sapiens
HIS A 302
HIS A 301
HIS A 160
HIS A 161
HIS A 157
ZN A 402 (-3.5A)
ZN A 401 (-3.4A)
ZN A 402 (-3.2A)
ZN A 401 (-3.3A)
ZN A 401 ( 3.2A)
1.17A 5mewA-4zyoA:
undetectable
5mewA-4zyoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0 1hcy ARTHROPODAN
HEMOCYANIN


Panulirus
interruptus
HIS A 198
HIS A 194
HIS A 344
HIS A 224
HIS A 384
CU A 665 (-3.1A)
CU A 665 (-3.0A)
CU A 666 (-3.1A)
CU A 665 (-3.5A)
CU A 666 (-3.4A)
1.22A 5mhuA-1hcyA:
undetectable
5mhuA-1hcyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0 3hhs PHENOLOXIDASE
SUBUNIT 2


Manduca sexta
HIS A 408
HIS A 368
HIS A 215
HIS A 245
HIS A 219
CU A 697 (-3.1A)
CU A 697 (-3.2A)
CU A 696 (-3.2A)
CU A 696 (-3.2A)
CU A 696 (-3.3A)
1.46A 5mhuA-3hhsA:
undetectable
5mhuA-3hhsA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0 3w6q TYROSINASE

Aspergillus
oryzae
HIS A 372
HIS A 328
HIS A 67
HIS A 103
HIS A 94
None
1.34A 5mhuA-3w6qA:
undetectable
5mhuA-3w6qA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0 4bed HEMOCYANIN KLH1

Megathura
crenulata
HIS B3106
HIS B3075
HIS B2946
HIS B2974
HIS B2965
CUO B9008 (-3.3A)
CUO B9008 (-2.8A)
CUO B9008 (-3.1A)
CUO B9008 (-2.9A)
CUO B9008 (-3.2A)
1.31A 5mhuA-4bedB:
undetectable
5mhuA-4bedB:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE


Agaricus bisporus
HIS A 255
HIS A 251
HIS A 57
HIS A 283
HIS A 91
CU1 A 402 (-3.1A)
CU1 A 402 (-3.0A)
CU1 A 401 (-3.2A)
CU1 A 402 (-2.9A)
CU1 A 401 (-3.3A)
1.32A 5mhuA-4ouaA:
undetectable
5mhuA-4ouaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0 4ymk ACYL-COA
DESATURASE 1


Mus musculus
HIS A 157
HIS A 156
HIS A 297
HIS A 298
HIS A 294
ZN A 401 (-3.3A)
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 402 (-3.4A)
ZN A 402 (-3.1A)
1.13A 5mhuA-4ymkA:
undetectable
5mhuA-4ymkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0 4ymk ACYL-COA
DESATURASE 1


Mus musculus
HIS A 298
HIS A 297
HIS A 156
HIS A 157
HIS A 153
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 402 (-3.4A)
ZN A 401 (-3.3A)
ZN A 401 ( 3.2A)
1.01A 5mhuA-4ymkA:
undetectable
5mhuA-4ymkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0 4yzw AGAP004976-PA

Anopheles gambiae
HIS A 419
HIS A 379
HIS A 223
HIS A 252
HIS A 227
CU A 802 (-3.1A)
CU A 802 (-3.2A)
CU A 801 (-3.0A)
CU A 801 (-3.2A)
CU A 801 (-3.2A)
1.37A 5mhuA-4yzwA:
undetectable
5mhuA-4yzwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0 4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
ZN A 401 (-3.5A)
1.10A 5mhuA-4zr0A:
undetectable
5mhuA-4zr0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0 4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
ZN A 402 (-3.4A)
ZN A 402 (-3.5A)
1.14A 5mhuA-4zr0A:
undetectable
5mhuA-4zr0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
ZN A 402 (-3.5A)
ZN A 401 ( 3.4A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
ZN A 401 (-3.4A)
1.14A 5mhuA-4zr1A:
undetectable
5mhuA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 401 ( 3.4A)
ZN A 402 (-3.5A)
ZN A 402 (-3.3A)
1.18A 5mhuA-4zr1A:
undetectable
5mhuA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0 4zyo ACYL-COA
DESATURASE


Homo sapiens
HIS A 302
HIS A 301
HIS A 160
HIS A 161
HIS A 157
ZN A 402 (-3.5A)
ZN A 401 (-3.4A)
ZN A 402 (-3.2A)
ZN A 401 (-3.3A)
ZN A 401 ( 3.2A)
1.17A 5mhuA-4zyoA:
undetectable
5mhuA-4zyoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0 1hcy ARTHROPODAN
HEMOCYANIN


Panulirus
interruptus
HIS A 198
HIS A 194
HIS A 344
HIS A 224
HIS A 384
CU A 665 (-3.1A)
CU A 665 (-3.0A)
CU A 666 (-3.1A)
CU A 665 (-3.5A)
CU A 666 (-3.4A)
1.22A 5mhvA-1hcyA:
undetectable
5mhvA-1hcyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0 3hhs PHENOLOXIDASE
SUBUNIT 2


Manduca sexta
HIS A 408
HIS A 368
HIS A 215
HIS A 245
HIS A 219
CU A 697 (-3.1A)
CU A 697 (-3.2A)
CU A 696 (-3.2A)
CU A 696 (-3.2A)
CU A 696 (-3.3A)
1.46A 5mhvA-3hhsA:
undetectable
5mhvA-3hhsA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0 3w6q TYROSINASE

Aspergillus
oryzae
HIS A 372
HIS A 328
HIS A 67
HIS A 103
HIS A 94
None
1.34A 5mhvA-3w6qA:
undetectable
5mhvA-3w6qA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE


Agaricus bisporus
HIS A 255
HIS A 251
HIS A 57
HIS A 283
HIS A 91
CU1 A 402 (-3.1A)
CU1 A 402 (-3.0A)
CU1 A 401 (-3.2A)
CU1 A 402 (-2.9A)
CU1 A 401 (-3.3A)
1.32A 5mhvA-4ouaA:
undetectable
5mhvA-4ouaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0 4ymk ACYL-COA
DESATURASE 1


Mus musculus
HIS A 157
HIS A 156
HIS A 297
HIS A 298
HIS A 294
ZN A 401 (-3.3A)
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 402 (-3.4A)
ZN A 402 (-3.1A)
1.14A 5mhvA-4ymkA:
undetectable
5mhvA-4ymkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0 4ymk ACYL-COA
DESATURASE 1


Mus musculus
HIS A 298
HIS A 297
HIS A 156
HIS A 157
HIS A 153
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 402 (-3.4A)
ZN A 401 (-3.3A)
ZN A 401 ( 3.2A)
1.02A 5mhvA-4ymkA:
undetectable
5mhvA-4ymkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0 4yzw AGAP004976-PA

Anopheles gambiae
HIS A 419
HIS A 379
HIS A 223
HIS A 252
HIS A 227
CU A 802 (-3.1A)
CU A 802 (-3.2A)
CU A 801 (-3.0A)
CU A 801 (-3.2A)
CU A 801 (-3.2A)
1.37A 5mhvA-4yzwA:
undetectable
5mhvA-4yzwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0 4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
ZN A 402 (-3.4A)
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
ZN A 401 (-3.5A)
1.11A 5mhvA-4zr0A:
undetectable
5mhvA-4zr0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0 4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
ZN A 402 (-3.4A)
ZN A 402 (-3.5A)
1.15A 5mhvA-4zr0A:
undetectable
5mhvA-4zr0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
ZN A 402 (-3.5A)
ZN A 401 ( 3.4A)
ZN A 402 (-3.3A)
ZN A 401 (-3.2A)
ZN A 401 (-3.4A)
1.15A 5mhvA-4zr1A:
undetectable
5mhvA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7


Saccharomyces
cerevisiae
HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
ZN A 401 (-3.2A)
ZN A 402 (-3.3A)
ZN A 401 ( 3.4A)
ZN A 402 (-3.5A)
ZN A 402 (-3.3A)
1.19A 5mhvA-4zr1A:
undetectable
5mhvA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0 4zyo ACYL-COA
DESATURASE


Homo sapiens
HIS A 302
HIS A 301
HIS A 160
HIS A 161
HIS A 157
ZN A 402 (-3.5A)
ZN A 401 (-3.4A)
ZN A 402 (-3.2A)
ZN A 401 (-3.3A)
ZN A 401 ( 3.2A)
1.17A 5mhvA-4zyoA:
undetectable
5mhvA-4zyoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1 3ahm OLIGOPEPTIDASE

Geobacillus sp.
MO-1
TYR A 328
SER A 325
ALA A 324
GLN A 74
THR A 65
None
1.11A 5n0wB-3ahmA:
undetectable
5n0wB-3ahmA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1 3ahm OLIGOPEPTIDASE

Geobacillus sp.
MO-1
TYR A 328
SER A 325
ALA A 324
GLN A 74
THR A 65
None
1.16A 5n4iA-3ahmA:
undetectable
5n4iA-3ahmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1 2vqa SLL1358 PROTEIN

Synechocystis sp.
PCC 6803
ILE A 272
HIS A 329
GLU A 290
HIS A 285
HIS A 283
None
MN A1006 (-3.5A)
MN A1006 ( 2.3A)
MN A1006 ( 3.5A)
MN A1006 ( 3.4A)
1.05A 5n5kA-2vqaA:
undetectable
5n5kA-2vqaA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1 3b6y GAMMA-INTERFERON-I
NDUCIBLE PROTEIN
IFI-16


Homo sapiens
ALA A 32
VAL A 12
LYS A 51
PHE A 30
ILE A 60
None
1.15A 5of1A-3b6yA:
undetectable
5of1A-3b6yA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1 3rn2 INTERFERON-INDUCIB
LE PROTEIN AIM2


Homo sapiens
ALA A 179
VAL A 158
LYS A 198
PHE A 177
ILE A 207
None
1.20A 5of1A-3rn2A:
undetectable
5of1A-3rn2A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1 3b6y GAMMA-INTERFERON-I
NDUCIBLE PROTEIN
IFI-16


Homo sapiens
ALA A 15
VAL A 12
LYS A 51
PHE A 30
ILE A 60
None
1.48A 5of1B-3b6yA:
undetectable
5of1B-3b6yA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1 4jbm INTERFERON-INDUCIB
LE PROTEIN AIM2


Mus musculus
ALA A 11
VAL A 8
LYS A 48
PHE A 27
ILE A 57
None
1.50A 5of1B-4jbmA:
undetectable
5of1B-4jbmA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0 2ysk HYPOTHETICAL
PROTEIN TTHA1432


Thermus
thermophilus
LEU A 37
LYS A 34
ALA A 38
LEU A 39
LEU A 27
None
1.45A 5vkqA-2yskA:
undetectable
5vkqD-2yskA:
undetectable
5vkqA-2yskA:
6.69
5vkqD-2yskA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0 3r0s ACYL-[ACYL-CARRIER
-PROTEIN]--UDP-N-A
CETYLGLUCOSAMINE
O-ACYLTRANSFERASE


Campylobacter
jejuni
LEU A 224
LYS A 225
ALA A 228
LEU A 231
LEU A 248
None
1.17A 5vkqA-3r0sA:
undetectable
5vkqD-3r0sA:
undetectable
5vkqA-3r0sA:
11.10
5vkqD-3r0sA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0 4xj6 VC0179-LIKE
PROTEIN


Escherichia coli
LEU A 324
LYS A 323
ALA A 326
LEU A 329
LEU A 373
None
1.22A 5vkqA-4xj6A:
undetectable
5vkqD-4xj6A:
undetectable
5vkqA-4xj6A:
12.73
5vkqD-4xj6A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0 2ysk HYPOTHETICAL
PROTEIN TTHA1432


Thermus
thermophilus
LEU A 27
LEU A 37
LYS A 34
ALA A 38
LEU A 39
None
1.44A 5vkqA-2yskA:
undetectable
5vkqB-2yskA:
undetectable
5vkqA-2yskA:
6.69
5vkqB-2yskA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0 3ah6 DIVALENT-CATION
TOLERANCE PROTEIN
CUTA


Escherichia coli
LEU A 111
LEU A 32
LYS A 35
ALA A 37
LEU A 66
None
1.45A 5vkqA-3ah6A:
undetectable
5vkqB-3ah6A:
undetectable
5vkqA-3ah6A:
6.04
5vkqB-3ah6A:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0 3r0s ACYL-[ACYL-CARRIER
-PROTEIN]--UDP-N-A
CETYLGLUCOSAMINE
O-ACYLTRANSFERASE


Campylobacter
jejuni
LEU A 248
LEU A 224
LYS A 225
ALA A 228
LEU A 231
None
1.14A 5vkqA-3r0sA:
undetectable
5vkqB-3r0sA:
undetectable
5vkqA-3r0sA:
11.10
5vkqB-3r0sA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0 4xj6 VC0179-LIKE
PROTEIN


Escherichia coli
LEU A 373
LEU A 324
LYS A 323
ALA A 326
LEU A 329
None
1.19A 5vkqA-4xj6A:
undetectable
5vkqB-4xj6A:
undetectable
5vkqA-4xj6A:
12.73
5vkqB-4xj6A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0 2ysk HYPOTHETICAL
PROTEIN TTHA1432


Thermus
thermophilus
LEU A 27
LEU A 37
LYS A 34
ALA A 38
LEU A 39
None
1.44A 5vkqB-2yskA:
undetectable
5vkqC-2yskA:
undetectable
5vkqB-2yskA:
6.69
5vkqC-2yskA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0 3ah6 DIVALENT-CATION
TOLERANCE PROTEIN
CUTA


Escherichia coli
LEU A 111
LEU A 32
LYS A 35
ALA A 37
LEU A 66
None
1.46A 5vkqB-3ah6A:
undetectable
5vkqC-3ah6A:
undetectable
5vkqB-3ah6A:
6.04
5vkqC-3ah6A:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0 3r0s ACYL-[ACYL-CARRIER
-PROTEIN]--UDP-N-A
CETYLGLUCOSAMINE
O-ACYLTRANSFERASE


Campylobacter
jejuni
LEU A 248
LEU A 224
LYS A 225
ALA A 228
LEU A 231
None
1.13A 5vkqB-3r0sA:
undetectable
5vkqC-3r0sA:
undetectable
5vkqB-3r0sA:
11.10
5vkqC-3r0sA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0 4xj6 VC0179-LIKE
PROTEIN


Escherichia coli
LEU A 373
LEU A 324
LYS A 323
ALA A 326
LEU A 329
None
1.21A 5vkqB-4xj6A:
undetectable
5vkqC-4xj6A:
undetectable
5vkqB-4xj6A:
12.73
5vkqC-4xj6A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0 1nw1 CHOLINE KINASE
(49.2 KD)


Caenorhabditis
elegans
LEU A 76
LEU A 52
LYS A 53
ALA A 56
LEU A 59
None
1.16A 5vkqC-1nw1A:
0.0
5vkqD-1nw1A:
2.1
5vkqC-1nw1A:
13.40
5vkqD-1nw1A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0 2ysk HYPOTHETICAL
PROTEIN TTHA1432


Thermus
thermophilus
LEU A 27
LEU A 37
LYS A 34
ALA A 38
LEU A 39
None
1.43A 5vkqC-2yskA:
undetectable
5vkqD-2yskA:
undetectable
5vkqC-2yskA:
6.69
5vkqD-2yskA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0 3r0s ACYL-[ACYL-CARRIER
-PROTEIN]--UDP-N-A
CETYLGLUCOSAMINE
O-ACYLTRANSFERASE


Campylobacter
jejuni
LEU A 248
LEU A 224
LYS A 225
ALA A 228
LEU A 231
None
1.14A 5vkqC-3r0sA:
undetectable
5vkqD-3r0sA:
undetectable
5vkqC-3r0sA:
11.10
5vkqD-3r0sA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0 4xj6 VC0179-LIKE
PROTEIN


Escherichia coli
LEU A 373
LEU A 324
LYS A 323
ALA A 326
LEU A 329
None
1.19A 5vkqC-4xj6A:
undetectable
5vkqD-4xj6A:
undetectable
5vkqC-4xj6A:
12.73
5vkqD-4xj6A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0 5cqf L-LYSINE
6-MONOOXYGENASE


Pseudomonas
syringae group
genomosp. 3
ARG A 223
LEU A 200
PHE A 196
LEU A 193
PHE A 189
None
1.44A 5x19C-5cqfA:
undetectable
5x19J-5cqfA:
undetectable
5x19C-5cqfA:
21.84
5x19J-5cqfA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0 5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849


Brucella abortus
TYR A 235
ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.39A 5x1fW-5uc2A:
undetectable
5x1fW-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0 4fqn MALCAVERNIN

Homo sapiens
ARG A 354
LEU A 351
PHE A 348
LEU A 369
PHE A 365
None
1.49A 5xdxC-4fqnA:
undetectable
5xdxJ-4fqnA:
undetectable
5xdxC-4fqnA:
14.62
5xdxJ-4fqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0 1bt2 PROTEIN (CATECHOL
OXIDASE)


Ipomoea batatas
HIS A 240
HIS A 244
PHE A 270
HIS A 273
HIS A 274
C2O A 500 ( 3.2A)
C2O A 500 ( 3.2A)
C2O A 500 ( 4.8A)
None
C2O A 500 ( 3.2A)
0.35A 5zrdB-1bt2A:
undetectable
5zrdB-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0 2qt3 N-ISOPROPYLAMMELID
E ISOPROPYL
AMIDOHYDROLASE


Pseudomonas sp.
ADP
HIS A 60
HIS A 62
PHE A 158
HIS A 125
HIS A 217
ZN A 501 (-3.3A)
ZN A 501 (-3.3A)
None
None
ZN A 501 (-3.5A)
1.29A 5zrdB-2qt3A:
undetectable
5zrdB-2qt3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0 3g77 CYTOSINE DEAMINASE

Escherichia coli
HIS A 61
HIS A 63
PHE A 154
HIS A 122
HIS A 214
FE A 502 (-3.1A)
FE A 502 (-3.1A)
None
None
FE A 502 (-3.6A)
1.17A 5zrdB-3g77A:
undetectable
5zrdB-3g77A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0 4r85 CYTOSINE DEAMINASE

Klebsiella
pneumoniae
HIS A 56
HIS A 58
PHE A 149
HIS A 117
HIS A 209
FE2 A 502 (-3.4A)
FE2 A 502 ( 3.5A)
17E A 501 (-4.9A)
None
FE2 A 502 ( 3.4A)
1.35A 5zrdB-4r85A:
undetectable
5zrdB-4r85A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2 4b0s DEAMIDASE-DEPUPYLA
SE DOP


Acidothermus
cellulolyticus
VAL A 105
THR A 432
LEU A 258
VAL A 242
LEU A 265
None
1.36A 6bqgA-4b0sA:
undetectable
6bqgA-4b0sA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2 5ntf AMINOPEPTIDASE

Trypanosoma cruzi
VAL A 186
THR A 184
LEU A 64
VAL A 71
LEU A 56
None
1.33A 6bqgA-5ntfA:
undetectable
6bqgA-5ntfA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2 1v95 NUCLEAR RECEPTOR
COACTIVATOR 5


Homo sapiens
ILE A 67
GLN A 69
THR A 20
THR A 78
LEU A 49
None
1.49A 6f3mD-1v95A:
undetectable
6f3mD-1v95A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2 4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT


Desulfovibrio
salexigens
ILE A 157
GLN A 159
THR A 229
THR A 235
LEU A 168
None
1.49A 6f3mD-4n6kA:
undetectable
6f3mD-4n6kA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1 2p17 PIRIN-LIKE PROTEIN

Geobacillus
kaustophilus
LEU A 184
TYR A 188
ILE A 60
MET A 169
GLY A 152
None
1.39A 6hd6A-2p17A:
undetectable
6hd6A-2p17A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0 4c6o CAD PROTEIN

Homo sapiens
GLY A1543
THR A1544
HIS A1577
SER A1539
SER A1538
None
1.08A 6jmjA-4c6oA:
undetectable
6jmjA-4c6oA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0 1jed SULFATE
ADENYLYLTRANSFERAS
E


Saccharomyces
cerevisiae
ILE A 48
LEU A 49
ARG A 40
THR A 38
LEU A 37
None
0.94A 6nmpN-1jedA:
0.0
6nmpW-1jedA:
0.0
6nmpN-1jedA:
21.17
6nmpW-1jedA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0 1r6x ATP:SULFATE
ADENYLYLTRANSFERAS
E


Saccharomyces
cerevisiae
ILE A 48
LEU A 49
ARG A 40
THR A 38
LEU A 37
None
0.96A 6nmpN-1r6xA:
0.0
6nmpW-1r6xA:
0.0
6nmpN-1r6xA:
21.48
6nmpW-1r6xA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE
2


Saccharomyces
cerevisiae
ILE A 554
LEU A 556
ARG A 608
THR A 637
LEU A 638
None
1.44A 6nmpN-2zwaA:
undetectable
6nmpW-2zwaA:
undetectable
6nmpN-2zwaA:
20.73
6nmpW-2zwaA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0 4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE


Brucella
melitensis
ILE A 290
LEU A 274
ARG A 31
THR A 303
LEU A 5
None
1.49A 6nmpN-4k3zA:
undetectable
6nmpW-4k3zA:
undetectable
6nmpN-4k3zA:
20.96
6nmpW-4k3zA:
9.04