Ligand ID: YTZ


Drugbank ID:
DB06147
(Sulfathiazole)


Indication:
Sulfathiazole is effective against a wide range of gram positive and gram negative pathogenic microorganisms. Although no longer used in humans, it is used in cattle.

Get human targets for YTZ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'YTZ'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.37A23.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		1uk4 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU B 205
CYH B 265
PHE B 230
GLN B 244
1.32A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		1uw7 NSP9
(SARS-COV
HKU-39849)		5 / 9
GLN A  11
ALA A  30
VAL A  41
ARG A  39
ARG A  10
1.51A23.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU B1205
CYH B1265
PHE B1230
GLN B1244
1.22A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		4 / 8
LEU B 205
CYH B 265
PHE B 230
GLN B 244
1.37A23.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		3 / 3
PHE A  54
LYS A   7
SER A   5
1.51A16.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU B 205
CYH B 265
PHE B 230
GLN B 244
1.33A24.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 9
GLN A  29
LEU A  89
VAL A   4
MET A  34
ALA A  90
1.70A22.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
SER C 370
LEU C 374
CYH C 366
PHE C 364
1.39A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.36A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 8
LEU B 205
CYH B 265
PHE B 230
GLN B 244
1.34A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 8
LEU B 205
CYH B 265
PHE B 230
GLN B 244
1.38A24.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.35A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.39A23.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
GLN C 130
LEU C 133
ALA C  80
VAL C  77
ALA C 137
1.80A22.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 8
LEU B 205
CYH B 265
PHE B 230
GLN B 244
1.36A23.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		2w2g NSP3
(SARSr-CoV)		5 / 9
LEU B 603
LEU B 596
ALA B 540
VAL B 578
ARG B 579
1.70A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		2w2g NSP3
(SARSr)		5 / 11
ASN B 532
LEU B 533
ARG B 534
HIS B 539
ALA B 540
1.47A22.68
20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_A_YTZA802_1
(SEPIAPTERIN
REDUCTASE)		3bgf F26G19 FAB
(Mus
musculus)		5 / 10
SER L  34
LEU L  36
PHE L  98
TRP L  96
TYR L  91
1.74A22.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		3bgf F26G19 FAB
(Mus
musculus)		5 / 8
SER L  34
LEU L  36
PHE L  98
TRP L  96
TYR L  91
1.74A22.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
GLN B 526
LEU B 410
ALA B 528
VAL B 574
ALA B 403
1.70A17.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU B 205
CYH B 265
PHE B 230
GLN B 244
1.36A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
LEU C 205
CYH A 265
PHE A 230
GLN A 244
1.37A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 9
GLN C  11
LEU C 112
ARG C  39
ARG C  10
ALA C   8
1.63A19.40
None
GOL  C 125 (-4.0A)
None
GOL  C 125 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.39A24.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.38A23.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.39A23.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU B 205
CYH B 265
PHE B 230
GLN B 244
1.36A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		3sck ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
LEU E 478
ARG E 479
ASN E 409
TYR A  34
GLY E 480
1.71A21.74
17.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
GLN B 526
LEU B 410
ALA B 528
VAL B 574
ALA B 403
1.71A17.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU B 205
CYH B 265
PHE B 230
GLN B 244
1.39A23.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.40A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.35A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU B 205
CYH B 265
PHE B 230
GLN B 244
1.38A24.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 9
LEU D 419
LEU D 411
ALA D  79
VAL D 182
ARG D 278
1.54A18.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 9
LEU D 419
LEU D 411
ALA D  79
VAL D 182
ARG D 278
1.47A17.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 9
LEU B 419
LEU B 411
ALA B  79
VAL B 182
ARG B 278
1.46A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.41A19.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		5x29 ENVELOPE SMALL
MEMBRANE PROTEIN
(SARSr-CoV)		5 / 9
LEU B  18
LEU A  19
ALA C  22
VAL C  25
ALA B  22
1.77A14.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
SER B 949
LEU B 948
PHE C 558
GLN B 818
1.21A12.97
SER  B 949 ( 0.0A)
LEU  B 948 ( 0.6A)
PHE  C 558 ( 1.3A)
GLN  B 818 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ack ACE2
(Homo
sapiens)		5 / 9
GLN D 526
LEU D 410
ALA D 528
VAL D 574
ALA D 403
1.74A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ASN B 960
LEU B 959
ASN B 733
ALA B 732
GLY B 726
1.37A12.38
10.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		6jyt HELICASE
(SARSr-CoV)		5 / 11
LEU B 130
ARG B 129
HIS B  33
ASN B 107
ALA B 110
1.74A15.94
17.11
None
None
ZN  B 703 (-4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.38A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.37A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.39A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU B 205
CYH B 265
PHE B 230
GLN B 244
1.37A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU D 205
CYH D 265
PHE D 230
GLN D 244
1.36A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU C 205
CYH C 265
PHE C 230
GLN C 244
1.40A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.36A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ASN B 141
LEU B 114
HIS D 146
ALA B 126
TRP B 133
1.39A21.43
18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		6m71 NSP12
(SARS-CoV-2)		5 / 11
LEU A 727
GLN A 468
ASN A 705
TYR A 732
GLY A  44
1.71A12.14
12.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 838
CYH A 842
PHE A 419
TYR A 420
1.56A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6m71 NSP12
(SARS-CoV-2)		5 / 9
GLN A 224
LEU A  89
LEU A  90
VAL A 231
ALA A 195
1.70A13.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 245
PHE A 287
TRP A 290
PRO A 243
1.79A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 316
PHE A 287
TRP A 290
PRO A 243
1.42A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 240
TRP A 290
TYR A 238
PRO A 243
1.64A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ASN A 960
LEU A 959
ASN A 733
ALA A 732
GLY A 726
1.69A10.99
10.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6nur NSP12
(SARSr-CoV)		4 / 8
LEU A 316
PHE A 287
TRP A 290
PRO A 243
1.41A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vw1 ACE2
(Homo
sapiens)		5 / 9
GLN B 526
LEU B 410
ALA B 528
VAL B 574
ALA B 403
1.68A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vxs NSP3
(SARS-CoV-2)		5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vxs NSP3
(SARS-CoV-2)		5 / 9
LEU B 126
LEU B 153
ALA B 112
VAL B  95
ALA B 124
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 9
GLN B 131
LEU B 134
ALA B  81
VAL B  78
ALA B 138
1.74A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w02 NSP3
(SARS-CoV-2)		5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.68A21.25
APR  A 201 (-4.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6964
LEU A6857
CYH A7007
TRP A6987
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 8
SER B4325
CYH B4326
PHE B4321
PRO A6878
1.48A
None
None
None
SAM  A7104 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w6y NSP3
(SARS-CoV-2)		5 / 9
LEU B 126
LEU B 153
ALA B 112
VAL B  95
ALA B 124
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w6y NSP3
(SARS-CoV-2)		5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.70A
AMP  A 201 ( 4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER A6964
LEU A6857
CYH A7007
TRP A6987
1.77A18.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 8
SER D4325
CYH D4326
PHE D4321
PRO C6878
1.44A17.69
None
None
None
SAM  C7105 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 8
SER B4325
CYH B4326
PHE B4321
PRO A6878
1.45A17.69
None
None
None
SAM  A7102 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 185
PHE A 216
TYR A 233
GLN A 221
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
LEU C 185
PHE C 216
TYR C 233
GLN C 221
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 9
GLN A  11
LEU A  -8
LEU A 106
ALA A  30
VAL A  41
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wcf NSP3
(SARS-CoV-2)		5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wen NSP3
(SARS-CoV-2)		5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wey NSP3
(SARS-CoV-2)		5 / 9
LEU A 330
LEU A 357
ALA A 316
VAL A 299
ALA A 328
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		6wiq NSP7
(SARS-CoV-2)		3 / 3
PHE A  49
LYS A   2
SER A   1
1.58A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 8
SER B4325
CYH B4326
PHE B4321
PRO A6878
1.47A
None
None
None
SAH  A7102 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 8
SER D4325
CYH D4326
PHE D4321
PRO C6878
1.46A
None
None
None
SAH  C7102 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER C6964
LEU C6857
CYH C7007
TRP C6987
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6964
LEU A6857
CYH A7007
TRP A6987
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 8
SER B4325
CYH B4326
PHE B4321
PRO A6878
1.45A
None
None
None
SFG  A7103 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER A6964
LEU A6857
CYH A7007
TRP A6987
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER C6964
LEU C6857
CYH C7007
TRP C6987
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 8
SER D4325
CYH D4326
PHE D4321
PRO C6878
1.46A
None
None
None
SFG  C7103 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 9
GLN B 131
LEU B 134
ALA B  81
VAL B  78
ALA B 138
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU D 126
LEU D 153
ALA D 112
VAL D  95
ALA D 124
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU B 126
LEU B 153
ALA B 112
VAL B  95
ALA B 124
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU C 126
LEU C 153
ALA C 112
VAL C  95
ALA C 124
1.75A
APR  C 201 (-4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 8
SER B4325
CYH B4326
PHE B4321
PRO A6878
1.46A
None
None
None
SAH  A7101 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
LEU A 185
PHE A 216
TYR A 233
GLN A 221
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.36A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.44A19.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER E 371
LEU E 368
PHE E 342
TRP E 436
1.63A
DMS  E 901 ( 4.4A)
None
None
DMS  E 901 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
SER C 182
LEU C 181
PHE C 145
PRO B 171
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 371
LEU A 368
PHE A 342
TRP A 436
1.65A
DMS  A 901 ( 4.9A)
None
None
DMS  A 901 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER E 371
LEU E 368
PHE E 342
TRP E 436
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 371
LEU A 368
PHE A 342
TRP A 436
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER E 371
LEU E 368
PHE E 342
TRP E 436
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
SER L 182
LEU L 181
PHE L 145
PRO H 171
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU A  75
GLN D 118
ASN A 115
ALA A 112
GLY A  97
1.80A19.55
21.36
None
EDO  D 201 ( 4.4A)
EDO  D 201 (-3.4A)
None
EDO  A 202 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU C 126
LEU C 153
ALA C 112
VAL C  95
ALA C 124
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU E 126
LEU E 153
ALA E 112
VAL E  95
ALA E 124
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU D 126
LEU D 153
ALA D 112
VAL D  95
ALA D 124
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU B 126
LEU B 153
ALA B 112
VAL B  95
ALA B 124
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.70A
APR  A 201 (-4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU C 126
LEU C 153
ALA C 112
VAL C  95
ALA C 124
1.69A
APR  C 201 (-4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU E 126
LEU E 153
ALA E 112
VAL E  95
ALA E 124
1.69A
APR  E 201 (-4.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU D 126
LEU D 153
ALA D 112
VAL D  95
ALA D 124
1.73A
APR  D 201 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU B 126
LEU B 153
ALA B 112
VAL B  95
ALA B 124
1.70A
APR  B 201 (-4.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU A  75
GLN D 118
ASN A 115
ALA A 112
GLY A  97
1.80A19.55
21.36
None
EDO  A 207 ( 4.7A)
EDO  A 207 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU C 126
LEU C 153
ALA C 112
VAL C  95
ALA C 124
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU B 126
LEU B 153
ALA B 112
VAL B  95
ALA B 124
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
NSP7
(SARS-CoV-2)		4 / 8
SER C   4
CYH C   8
PHE A 843
TYR A 420
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 316
PHE A 287
TRP A 290
PRO A 243
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		7btf NSP12
(SARS-CoV-2)		5 / 11
LEU A 727
GLN A 468
ASN A 705
TYR A 732
GLY A  44
1.64A12.14
12.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 245
PHE A 287
TRP A 290
PRO A 243
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 838
CYH A 842
PHE A 419
TYR A 420
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 239
PHE A  45
TYR A 732
PRO A 243
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 240
TRP A 290
TYR A 238
PRO A 243
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
LEU A 240
TRP A 290
TYR A 238
PRO A 243
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
LEU A 727
GLN A 468
ASN A 705
TYR A 732
GLY A  44
1.59A12.28
12.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
LEU A 245
PHE A 287
TRP A 290
PRO A 243
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
SER A 236
PHE A  45
TYR A 728
GLN A 468
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		4 / 8
SER C   4
CYH C   8
PHE A 843
TYR A 420
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
LEU A 316
PHE A 287
TRP A 290
PRO A 243
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
LEU A 838
CYH A 842
PHE A 419
TYR A 420
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 838
CYH A 842
PHE A 419
TYR A 420
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 316
PHE A 287
TRP A 290
PRO A 243
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
LEU A 727
GLN A 468
ASN A 705
TYR A 732
GLY A  44
1.64A12.28
12.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 236
PHE A  45
TYR A 728
GLN A 468
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 240
TRP A 290
TYR A 238
PRO A 243
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		4 / 8
SER C   4
CYH C   8
PHE A 843
TYR A 420
1.21A
None