Ligand ID: YTZ


Drugbank ID:
DB06147
(Sulfathiazole)



Indication:
Sulfathiazole is effective against a wide range of gram positive and gram negative pathogenic microorganisms. Although no longer used in humans, it is used in cattle.


Get human targets for YTZ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'YTZ' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.


DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
View Interface RMSD Seq.
Identity (%)
HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)
4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.41A19.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6lze VIRAL PROTEASE
(SARS-CoV-2)
4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.38A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6m0k VIRAL PROTEASE
(SARS-CoV-2)
4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.37A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6m2n 3CL PROTEASE
(SARS-CoV-2)
4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.39A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6m2n 3CL PROTEASE
(SARS-CoV-2)
4 / 8
LEU B 205
CYH B 265
PHE B 230
GLN B 244
1.37A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6m2n 3CL PROTEASE
(SARS-CoV-2)
4 / 8
LEU D 205
CYH D 265
PHE D 230
GLN D 244
1.36A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6m2n 3CL PROTEASE
(SARS-CoV-2)
4 / 8
LEU C 205
CYH C 265
PHE C 230
GLN C 244
1.40A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6m2q 3CL PROTEASE
(SARS-CoV-2)
4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.36A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)
6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)
5 / 11
ASN B 141
LEU B 114
HIS D 146
ALA B 126
TRP B 133
1.39A21.43
18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)
6m71 NSP12
(SARS-CoV-2)
5 / 11
LEU A 727
GLN A 468
ASN A 705
TYR A 732
GLY A  44
1.71A12.14
12.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6m71 NSP12
(SARS-CoV-2)
4 / 8
LEU A 838
CYH A 842
PHE A 419
TYR A 420
1.56A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6m71 NSP12
(SARS-CoV-2)
5 / 9
GLN A 224
LEU A  89
LEU A  90
VAL A 231
ALA A 195
1.70A13.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6m71 NSP12
(SARS-CoV-2)
4 / 8
LEU A 245
PHE A 287
TRP A 290
PRO A 243
1.79A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6m71 NSP12
(SARS-CoV-2)
4 / 8
LEU A 316
PHE A 287
TRP A 290
PRO A 243
1.42A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6m71 NSP12
(SARS-CoV-2)
4 / 8
LEU A 240
TRP A 290
TYR A 238
PRO A 243
1.64A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6vxs NSP3
(SARS-CoV-2)
5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6vxs NSP3
(SARS-CoV-2)
5 / 9
LEU B 126
LEU B 153
ALA B 112
VAL B  95
ALA B 124
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)
5 / 9
GLN B 131
LEU B 134
ALA B  81
VAL B  78
ALA B 138
1.74A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6w02 NSP3
(SARS-CoV-2)
5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.68A21.25
APR  A 201 (-4.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)
4 / 8
SER A6964
LEU A6857
CYH A7007
TRP A6987
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)
4 / 8
SER B4325
CYH B4326
PHE B4321
PRO A6878
1.48A
None
None
None
SAM  A7104 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)
4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6w6y NSP3
(SARS-CoV-2)
5 / 9
LEU B 126
LEU B 153
ALA B 112
VAL B  95
ALA B 124
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6w6y NSP3
(SARS-CoV-2)
5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.70A
AMP  A 201 ( 4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6w75 NSP16
(SARS-CoV-2)
4 / 8
SER A6964
LEU A6857
CYH A7007
TRP A6987
1.77A18.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6w75 NSP10
NSP16
(SARS-CoV-2)
4 / 8
SER D4325
CYH D4326
PHE D4321
PRO C6878
1.44A17.69
None
None
None
SAM  C7105 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6w75 NSP10
NSP16
(SARS-CoV-2)
4 / 8
SER B4325
CYH B4326
PHE B4321
PRO A6878
1.45A17.69
None
None
None
SAM  A7102 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)
4 / 8
LEU A 185
PHE A 216
TYR A 233
GLN A 221
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)
4 / 8
LEU C 185
PHE C 216
TYR C 233
GLN C 221
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)
5 / 9
GLN A  11
LEU A  -8
LEU A 106
ALA A  30
VAL A  41
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6wcf NSP3
(SARS-CoV-2)
5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6wen NSP3
(SARS-CoV-2)
5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6wey NSP3
(SARS-CoV-2)
5 / 9
LEU A 330
LEU A 357
ALA A 316
VAL A 299
ALA A 328
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)
6wiq NSP7
(SARS-CoV-2)
3 / 3
PHE A  49
LYS A   2
SER A   1
1.58A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)
4 / 8
SER B4325
CYH B4326
PHE B4321
PRO A6878
1.47A
None
None
None
SAH  A7102 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)
4 / 8
SER D4325
CYH D4326
PHE D4321
PRO C6878
1.46A
None
None
None
SAH  C7102 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)
4 / 8
SER C6964
LEU C6857
CYH C7007
TRP C6987
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)
4 / 8
SER A6964
LEU A6857
CYH A7007
TRP A6987
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6wkq NSP10
NSP16
(SARS-CoV-2)
4 / 8
SER B4325
CYH B4326
PHE B4321
PRO A6878
1.45A
None
None
None
SFG  A7103 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6wkq NSP16
(SARS-CoV-2)
4 / 8
SER A6964
LEU A6857
CYH A7007
TRP A6987
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6wkq NSP16
(SARS-CoV-2)
4 / 8
SER C6964
LEU C6857
CYH C7007
TRP C6987
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6wkq NSP10
NSP16
(SARS-CoV-2)
4 / 8
SER D4325
CYH D4326
PHE D4321
PRO C6878
1.46A
None
None
None
SFG  C7103 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)
5 / 9
GLN B 131
LEU B 134
ALA B  81
VAL B  78
ALA B 138
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)
4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)
5 / 9
LEU D 126
LEU D 153
ALA D 112
VAL D  95
ALA D 124
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)
5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)
5 / 9
LEU B 126
LEU B 153
ALA B 112
VAL B  95
ALA B 124
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)
5 / 9
LEU C 126
LEU C 153
ALA C 112
VAL C  95
ALA C 124
1.75A
APR  C 201 (-4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)
4 / 8
SER B4325
CYH B4326
PHE B4321
PRO A6878
1.46A
None
None
None
SAH  A7101 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)
4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6wrh PEPTIDASE C16
(SARS-CoV-2)
4 / 8
LEU A 185
PHE A 216
TYR A 233
GLN A 221
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)
4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.36A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)
4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.44A19.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)
4 / 8
SER E 371
LEU E 368
PHE E 342
TRP E 436
1.63A
DMS  E 901 ( 4.4A)
None
None
DMS  E 901 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)
4 / 8
SER A 371
LEU A 368
PHE A 342
TRP A 436
1.65A
DMS  A 901 ( 4.9A)
None
None
DMS  A 901 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)
4 / 8
SER E 371
LEU E 368
PHE E 342
TRP E 436
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)
4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)
4 / 8
SER A 371
LEU A 368
PHE A 342
TRP A 436
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)
4 / 8
SER E 371
LEU E 368
PHE E 342
TRP E 436
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)
4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)
6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)
5 / 11
LEU A  75
GLN D 118
ASN A 115
ALA A 112
GLY A  97
1.80A19.55
21.36
None
EDO  D 201 ( 4.4A)
EDO  D 201 (-3.4A)
None
EDO  A 202 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)
5 / 9
LEU C 126
LEU C 153
ALA C 112
VAL C  95
ALA C 124
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)
5 / 9
LEU E 126
LEU E 153
ALA E 112
VAL E  95
ALA E 124
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)
5 / 9
LEU D 126
LEU D 153
ALA D 112
VAL D  95
ALA D 124
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)
5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)
5 / 9
LEU B 126
LEU B 153
ALA B 112
VAL B  95
ALA B 124
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)
5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.70A
APR  A 201 (-4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)
5 / 9
LEU C 126
LEU C 153
ALA C 112
VAL C  95
ALA C 124
1.69A
APR  C 201 (-4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)
5 / 9
LEU E 126
LEU E 153
ALA E 112
VAL E  95
ALA E 124
1.69A
APR  E 201 (-4.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)
5 / 9
LEU D 126
LEU D 153
ALA D 112
VAL D  95
ALA D 124
1.73A
APR  D 201 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)
5 / 9
LEU B 126
LEU B 153
ALA B 112
VAL B  95
ALA B 124
1.70A
APR  B 201 (-4.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)
6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)
5 / 11
LEU A  75
GLN D 118
ASN A 115
ALA A 112
GLY A  97
1.80A19.55
21.36
None
EDO  A 207 ( 4.7A)
EDO  A 207 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)
5 / 9
LEU C 126
LEU C 153
ALA C 112
VAL C  95
ALA C 124
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)
5 / 9
LEU A 126
LEU A 153
ALA A 112
VAL A  95
ALA A 124
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)
5 / 9
LEU B 126
LEU B 153
ALA B 112
VAL B  95
ALA B 124
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7bqy MAIN PROTEASE
(SARS-CoV-2)
4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7btf NSP12
NSP7
(SARS-CoV-2)
4 / 8
SER C   4
CYH C   8
PHE A 843
TYR A 420
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7btf NSP12
(SARS-CoV-2)
4 / 8
LEU A 316
PHE A 287
TRP A 290
PRO A 243
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)
7btf NSP12
(SARS-CoV-2)
5 / 11
LEU A 727
GLN A 468
ASN A 705
TYR A 732
GLY A  44
1.64A12.14
12.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7btf NSP12
(SARS-CoV-2)
4 / 8
LEU A 245
PHE A 287
TRP A 290
PRO A 243
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7btf NSP12
(SARS-CoV-2)
4 / 8
LEU A 838
CYH A 842
PHE A 419
TYR A 420
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7btf NSP12
(SARS-CoV-2)
4 / 8
SER A 239
PHE A  45
TYR A 732
PRO A 243
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7btf NSP12
(SARS-CoV-2)
4 / 8
LEU A 240
TRP A 290
TYR A 238
PRO A 243
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)
4 / 8
LEU A 205
CYH A 265
PHE A 230
GLN A 244
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7bv1 NSP12
(SARS-CoV-2)
4 / 8
LEU A 240
TRP A 290
TYR A 238
PRO A 243
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)
7bv1 NSP12
(SARS-CoV-2)
5 / 11
LEU A 727
GLN A 468
ASN A 705
TYR A 732
GLY A  44
1.59A12.28
12.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7bv1 NSP12
(SARS-CoV-2)
4 / 8
LEU A 245
PHE A 287
TRP A 290
PRO A 243
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7bv1 NSP12
(SARS-CoV-2)
4 / 8
SER A 236
PHE A  45
TYR A 728
GLN A 468
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7bv1 NSP12
NSP7
(SARS-CoV-2)
4 / 8
SER C   4
CYH C   8
PHE A 843
TYR A 420
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7bv1 NSP12
(SARS-CoV-2)
4 / 8
LEU A 316
PHE A 287
TRP A 290
PRO A 243
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7bv1 NSP12
(SARS-CoV-2)
4 / 8
LEU A 838
CYH A 842
PHE A 419
TYR A 420
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7bv2 NSP12
(SARS-CoV-2)
4 / 8
LEU A 838
CYH A 842
PHE A 419
TYR A 420
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7bv2 NSP12
(SARS-CoV-2)
4 / 8
LEU A 316
PHE A 287
TRP A 290
PRO A 243
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)
7bv2 NSP12
(SARS-CoV-2)
5 / 11
LEU A 727
GLN A 468
ASN A 705
TYR A 732
GLY A  44
1.64A12.28
12.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7bv2 NSP12
(SARS-CoV-2)
4 / 8
SER A 236
PHE A  45
TYR A 728
GLN A 468
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7bv2 NSP12
(SARS-CoV-2)
4 / 8
LEU A 240
TRP A 290
TYR A 238
PRO A 243
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
7bv2 NSP12
NSP7
(SARS-CoV-2)
4 / 8
SER C   4
CYH C   8
PHE A 843
TYR A 420
1.21A
None