Ligand ID: TCW


Drugbank ID:
DB00323
(Tolcapone)


Indication:
Used as an adjunct to levodopa/carbidopa therapy for the symptomatic treatment of Parkinson's Disease. This drug is generally reserved for patients with parkinsonian syndrome receiving levodopa/carbidopa who are experiencing symptom fluctuations and are not responding adequately to or are not candidates for other adjunctive therapies.

Get human targets for TCW in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'TCW'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		1wnc E2 GLYCOPROTEIN
(SARSr)		4 / 6
LYS F1172
ALA F1171
LEU F1167
THR F 921
1.45A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 6
LEU F 930
ALA F 926
LEU F 927
SER F 924
THR F 922
1.33A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU F 930
ALA F 926
LEU F 927
SER F 924
THR F 922
1.43A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		1wyy E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 6
LEU A 930
ALA A 926
LEU A 927
SER A 924
THR A 922
1.72A23.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		1wyy E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU A 930
ALA A 926
LEU A 927
SER A 924
THR A 922
1.68A23.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 6
LEU K  30
ALA K  26
LEU K  27
SER K  24
THR K  22
1.61A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU K  30
ALA K  26
LEU K  27
SER K  24
THR K  22
1.66A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B 202
ALA B 206
LEU B 205
VAL B 297
1.37A19.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU C 930
ALA C 926
LEU C 927
SER C 924
THR C 922
1.66A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 6
LEU C 930
ALA C 926
LEU C 927
SER C 924
THR C 922
1.61A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		2bez SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU C 930
ALA C 926
LEU C 927
SER C 924
THR C 922
1.73A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		2bez SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 6
LEU C 930
ALA C 926
LEU C 927
SER C 924
THR C 922
1.69A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU C  81
ALA C  69
LEU C  59
SER C  61
1.34A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
LYS C 293
LEU C 291
THR C 282
THR C 278
0.98A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU C  81
ALA C  69
LEU C  59
SER C  61
1.27A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 6
LEU A  66
ALA A  65
LEU A  66
SER A  67
1.13A27.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 6
LEU A  66
LEU A  66
SER A  67
VAL A  78
1.28A26.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 6
LEU A  66
ALA A  65
LEU A  66
SER A  67
1.10A26.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 6
LEU A  66
LEU A  66
SER A  67
THR A  68
1.39A27.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 202
ALA A 206
LEU A 205
VAL A 297
1.36A18.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2jzd REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU A 596
ALA A 631
LEU A 546
VAL A 633
1.33A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2kqv NSP3
(SARSr-CoV)		4 / 6
LEU A  74
ALA A 109
LEU A  24
VAL A 111
1.20A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.19A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.34A11.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.01A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 202
ALA A 206
LEU A 205
VAL A 297
1.38A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3e9s NSP3
(SARSr-CoV)		4 / 7
LYS A 293
LEU A 291
THR A 282
THR A 278
1.20A19.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B 202
ALA B 206
LEU B 205
VAL B 297
1.35A19.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 202
ALA A 206
LEU A 205
VAL A 297
1.35A19.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU A 202
ALA A 206
LEU A 205
VAL C 297
1.37A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 202
ALA A 206
LEU A 205
VAL A 297
1.39A18.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
LYS A 293
LEU A 291
THR A 282
THR A 278
1.03A19.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		3sci ACE2
(Homo
sapiens)		4 / 6
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.31A10.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
LYS A  68
LEU A  39
ALA A  65
SER A  44
1.03A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.25A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.34A11.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3v3m 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 202
ALA A 206
LEU A 205
VAL A 297
1.34A19.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		4m0w UBIQUITIN
(Bos
taurus)		4 / 6
LYS B  48
LEU B  50
ALA B  46
LEU B  67
1.24A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		4 / 6
LEU A  81
ALA A  69
LEU A  59
SER A  61
1.32A19.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 6
LYS A 291
ALA A 282
LEU A 284
VAL A 268
1.01A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 6
LEU A 113
ALA A 115
LEU A 104
SER A 103
1.28A18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
LEU D 109
THR D 122
ALA D 119
LEU D 117
1.01A16.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
LEU D 109
THR D 122
ALA D 119
LEU D 117
1.04A14.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
LYS D 293
LEU D 291
THR D 282
THR D 278
0.98A19.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 7
LEU A 109
THR A 122
ALA A 119
LEU A 117
1.05A12.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
LEU A 205
THR A 224
ALA A 266
LEU A 268
1.53A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
LEU A 287
LEU A 286
SER A 284
THR A 280
1.65A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 286
ALA A 285
LEU A 287
THR A 280
1.72A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
LEU A 205
THR A 224
LEU A 242
THR A 226
1.79A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
LEU A  87
THR A  25
LEU A  89
THR A  21
1.61A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
LEU A 286
ALA A 285
LEU A 287
THR A 280
1.71A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU B  81
ALA B  69
LEU B  59
SER B  61
1.14A19.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
LYS B 293
LEU B 291
THR B 282
THR B 278
1.07A19.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		5tl7 UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus)		4 / 6
LEU C 105
LEU C 122
SER C 123
THR C 145
1.32A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 7
LEU C 745
THR B 991
LEU C 986
SER C 985
THR C 988
1.76A8.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		5x5c S PROTEIN
(MERS-CoV)		4 / 6
ALA B 760
LEU B 722
SER B 721
VAL B 714
1.39A6.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5x5f S PROTEIN
(MERS-CoV)		4 / 7
THR B 669
ALA B 671
LEU B 673
SER B 660
0.84A6.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU A 636
ALA A 595
LEU A 597
SER A 582
1.09A7.56
LEU  A 636 ( 0.6A)
ALA  A 595 ( 0.0A)
LEU  A 597 ( 0.6A)
SER  A 582 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
LEU A 636
ALA A 595
LEU A 597
SER A 582
1.12A7.56
LEU  A 636 ( 0.6A)
ALA  A 595 ( 0.0A)
LEU  A 597 ( 0.6A)
SER  A 582 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU A 636
ALA A 595
LEU A 597
SER A 582
0.72A7.56
LEU  A 636 ( 0.6A)
ALA  A 595 ( 0.0A)
LEU  A 597 ( 0.6A)
SER  A 582 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
LYS A 293
LEU A 291
THR A 282
THR A 278
1.16A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5zvm SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU B 930
ALA B 926
LEU B 927
SER B 924
THR B 922
1.70A22.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		5zvm SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 6
LEU B 930
ALA B 926
LEU B 927
SER B 924
THR B 922
1.70A22.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6acg ACE2
(Homo
sapiens)		4 / 6
ALA D 396
LEU D 560
SER D 563
VAL D 209
1.35A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
LEU B 597
ALA B 633
LEU B 636
THR B 631
0.83A7.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU A 636
ALA A 595
LEU A 597
SER A 582
0.94A7.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU A 636
ALA A 595
LEU A 597
SER A 582
0.75A7.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
LEU B 636
ALA B 595
LEU B 597
SER B 582
0.73A7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
LEU B 636
ALA B 595
LEU B 597
SER B 582
1.07A7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
LEU B 636
ALA B 595
LEU B 597
SER B 582
0.95A7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
LEU B 636
ALA B 595
LEU B 597
SER B 582
0.94A7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
LEU B 636
ALA B 595
LEU B 597
SER B 582
0.64A7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
LEU A 287
LEU A 286
SER A 284
THR A 280
1.59A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
LEU A 287
LEU A 286
SER A 284
THR A 280
1.60A17.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6m18 ACE2
(Homo
sapiens)		4 / 6
LYS D  68
LEU D  39
ALA D  65
SER D  44
1.21A9.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6m18 ACE2
(Homo
sapiens)		4 / 6
LYS D  68
LEU D  39
ALA D  65
SER D  44
0.97A9.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6m18 ACE2
(Homo
sapiens)		4 / 7
LYS D  68
LEU D  39
ALA D  65
SER D  44
1.04A9.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
LEU B 205
THR B 224
ALA B 266
LEU B 268
1.49A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
LEU A 205
THR A 224
ALA A 266
LEU A 268
1.49A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU B 286
ALA B 285
LEU B 287
THR B 280
1.72A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
LEU A  87
THR A  25
LEU A  89
THR A  21
1.59A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 286
ALA A 285
LEU A 287
THR A 280
1.74A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU B 128
ALA A 400
SER A 397
VAL A 405
1.62A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 7
THR A 402
ALA A 400
LEU A 389
SER A 397
1.52A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 7
LEU A 186
THR A 248
ALA A 250
THR A 246
1.55A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 7
LEU A 576
ALA A 580
SER A 578
THR A 582
1.63A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 7
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.57A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 245
ALA A 250
LEU A 316
THR A 252
1.80A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.50A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LYS A 641
LEU A 575
LEU A 638
SER A 635
1.42A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 387
ALA A 400
SER A 397
VAL A 405
1.55A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 576
ALA A 580
SER A 578
THR A 582
1.66A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 251
ALA A 250
LEU A 316
THR A 248
1.77A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ALA A 660
LEU A 663
SER A 664
VAL A 535
1.66A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6m71 NSP7
(SARS-CoV-2)		4 / 6
ALA C  65
LEU C  60
SER C  61
VAL C  22
1.64A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU A 636
ALA A 595
LEU A 597
SER A 582
1.06A7.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
LEU C 636
ALA C 595
LEU C 597
SER C 582
0.90A7.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 140
ALA H 151
SER H 146
THR H 149
1.17A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		4 / 7
LEU H  11
THR H  91
ALA H 124
THR H 122
1.21A19.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6nur NSP12
(SARSr-CoV)		4 / 6
LEU A 387
ALA A 400
SER A 397
VAL A 405
1.38A9.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6nur NSP7
(SARSr-CoV)		4 / 6
LEU C  17
LEU C  14
SER C  10
VAL C  53
1.36A23.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6nur NSP12
(SARSr-CoV)		4 / 6
LYS A 641
LEU A 575
LEU A 638
SER A 635
1.33A8.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU C 650
ALA C 609
LEU C 611
SER C 596
0.94A7.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 650
ALA A 609
LEU A 611
SER A 596
0.95A7.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
LEU C 650
ALA C 609
LEU C 611
SER C 596
1.11A7.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6vw1 ACE2
(Homo
sapiens)		4 / 6
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.10A10.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6vw1 ACE2
(Homo
sapiens)		4 / 7
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.24A10.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6vw1 ACE2
(Homo
sapiens)		4 / 6
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.33A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6vxs NSP3
(SARS-CoV-2)		4 / 6
LEU B  43
ALA B  39
LEU B  75
VAL B  36
1.60A
None
None
SO4  B 201 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6vxs NSP3
(SARS-CoV-2)		4 / 6
LEU A  53
ALA A  39
SER A  65
VAL A  95
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6vxs NSP3
(SARS-CoV-2)		4 / 6
LEU B  53
ALA B  39
SER B  65
VAL B  95
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6vxs NSP3
(SARS-CoV-2)		4 / 6
LEU A  43
ALA A  39
LEU A  75
VAL A  36
1.60A
None
None
SO4  A 201 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU B 650
ALA B 609
LEU B 611
SER B 596
0.80A7.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 650
ALA A 609
LEU A 611
SER A 596
1.10A7.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU B 650
ALA B 609
LEU B 611
SER B 596
0.79A7.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU B 650
ALA B 609
LEU B 611
SER B 596
1.11A7.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
LEU L 135
ALA H 137
SER L 114
VAL H 184
1.34A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
LEU L 136
LEU L 175
SER L 162
VAL H 181
1.57A22.16
None
None
GOL  L 301 (-3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
LEU H  18
THR H 108
LEU H  82
THR H  87
1.78A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
LYS H 143
LEU H 141
SER H 180
VAL H 169
1.68A24.68
None
None
None
GOL  L 301 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
LEU H 189
ALA H 136
SER H 132
THR H 131
1.63A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
ALA H 137
LEU L 135
SER L 114
VAL H 184
1.64A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
LEU L 135
ALA H 137
SER L 114
THR H 135
1.59A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		4 / 7
THR H 100
LEU C 513
SER C 514
THR C 430
1.80A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
LEU H 189
ALA H 136
SER H 132
THR H 131
1.63A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
THR H 108
ALA H  88
SER H  85
THR H  87
1.72A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
LEU H 138
THR H 135
ALA H 136
SER H 127
1.68A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
LEU H 124
THR H 183
ALA H 137
SER H 127
1.58A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
LYS H 143
LEU H 141
LEU H 124
VAL H 169
1.72A24.68
None
None
None
GOL  L 301 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
LEU L  73
ALA L  19
SER L  76
VAL L  13
1.62A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
LEU H 138
THR H 135
ALA H 137
LEU H 124
1.55A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
LEU H  18
THR H   9
LEU H  82
THR H 110
1.65A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
LEU L 135
ALA H 137
SER L 114
THR H 135
1.56A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 6
LEU A6883
ALA A6881
LEU A6893
VAL B4295
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6834
THR A6993
ALA A6843
THR A6846
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7078
THR A7055
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6852
THR A6989
LEU A6857
SER A6964
1.64A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w61 NSP10
(SARS-CoV-2)		4 / 6
LEU B4328
ALA B4276
LEU B4365
VAL B4274
1.75A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
LEU A  87
THR A  25
LEU A  89
THR A  21
1.60A
None
X77  A 401 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LYS A 137
ALA A 129
SER A 113
THR A 111
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU A  53
ALA A  39
SER A  65
VAL A  95
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU B  75
LEU B  43
SER B  65
VAL B  36
1.75A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU A  75
LEU A  43
SER A  65
VAL A  36
1.77A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU B  43
ALA B  39
LEU B  75
VAL B  36
1.72A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU B 153
LEU B 126
SER B 139
VAL B  95
1.75A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU B  53
ALA B  39
SER B  65
VAL B  95
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
LEU A 122
THR A 146
LEU A  93
SER A  80
1.74A19.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU A  43
ALA A  39
LEU A  75
VAL A  36
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU C7073
THR C7055
ALA C6858
SER C6964
1.71A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A6852
THR A6989
LEU A6857
SER A6964
1.63A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A6834
THR A6993
ALA A6843
THR A6846
1.60A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU C6834
THR C6993
ALA C6843
THR C6846
1.62A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7078
THR A7055
1.67A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 6
LEU A6883
ALA A6881
LEU A6893
VAL B4295
1.43A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 6
LEU A6883
ALA A6881
SER A6903
VAL B4295
1.63A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU C6893
ALA C6905
SER C6907
THR C6908
1.77A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 6
LEU C6883
ALA C6881
SER C6903
VAL D4295
1.61A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU C6852
THR C6989
LEU C6857
SER C6964
1.62A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU C7073
ALA C6858
LEU C7078
THR C7055
1.65A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 6
LEU C6883
ALA C6881
LEU C6893
VAL D4295
1.44A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A6893
ALA A6905
SER A6907
THR A6908
1.78A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
LEU B 117
THR B 168
ALA B 116
LEU B 118
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
LYS A 292
LEU A 290
THR A 281
THR A 277
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
LYS C 292
LEU C 290
THR C 281
THR C 277
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR C 119
ALA C 116
LEU C 113
THR C 115
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
LYS B 292
LEU B 290
THR B 281
THR B 277
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR B 119
ALA B 116
LEU B 113
THR B 115
1.49A
None
None
None
CL  B 502 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
LEU A 117
THR A 168
ALA A 116
LEU A 118
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 119
ALA A 116
LEU A 113
THR A 115
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
LEU C 117
THR C 168
ALA C 116
LEU C 118
1.10A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU C 113
ALA C 144
SER C 103
THR C 102
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU B 113
ALA B 144
SER B 103
THR B 102
1.74A
None
None
CL  B 502 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 6
LEU A 103
ALA A 107
SER A 105
THR A 109
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 7
LYS A  86
LEU A  45
THR A  77
THR A 109
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 7
LEU A  88
THR A  77
SER A 105
THR A 109
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wcf NSP3
(SARS-CoV-2)		4 / 6
LEU A  53
ALA A  39
SER A  65
VAL A  95
1.62A
None
MES  A 201 ( 4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wen NSP3
(SARS-CoV-2)		4 / 6
LEU A  43
ALA A  39
LEU A  75
VAL A  36
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wen NSP3
(SARS-CoV-2)		4 / 6
LEU A  53
ALA A  39
SER A  65
VAL A  95
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wey NSP3
(SARS-CoV-2)		4 / 6
LEU A 257
ALA A 243
SER A 269
VAL A 299
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wey NSP3
(SARS-CoV-2)		4 / 6
LEU A 247
ALA A 243
LEU A 279
VAL A 240
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wiq NSP7
(SARS-CoV-2)		4 / 6
LEU A  17
LEU A  14
SER A  10
VAL A  53
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
LEU C 291
THR C 263
ALA C 264
THR C 265
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
LEU B 291
THR B 263
ALA B 264
THR B 265
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
LEU F 291
THR F 263
ALA F 264
THR F 265
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
LYS B 261
THR B 263
ALA A 313
SER A 318
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
LEU E 291
THR E 263
ALA E 264
THR E 265
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6834
THR A6993
ALA A6843
THR A6846
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU C6852
THR C6989
LEU C6857
SER C6964
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7078
THR A7055
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6852
THR A6989
LEU A6857
SER A6964
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 6
LEU A6883
ALA A6881
SER A6903
VAL B4295
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU C6834
THR C6993
ALA C6843
THR C6846
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 6
LEU A6883
ALA A6881
LEU A6893
VAL B4295
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU C7073
ALA C6858
LEU C7078
THR C7055
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 6
LEU C6883
ALA C6881
SER C6903
VAL D4295
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 6
LEU C6883
ALA C6881
LEU C6893
VAL D4295
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU C6893
ALA C6905
SER C6907
THR C6908
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6883
ALA A6881
LEU A6893
VAL A6876
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU C  56
ALA C 173
SER D  78
THR D  76
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU A  56
ALA A 173
SER B  78
THR B  76
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
LEU C  56
ALA C 173
SER D  78
THR D  76
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
LEU A 161
ALA A 173
LEU A 159
THR B  76
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU C 159
ALA C  55
SER D  78
THR C  57
1.75A
None
MES  D 201 (-3.3A)
None
ZN  D 202 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU C 161
ALA C 173
LEU C 159
THR D  76
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU A 161
ALA A 173
LEU A 159
THR B  76
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
LEU A  56
ALA A 173
SER B  78
THR B  76
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wkq NSP16
(SARS-CoV-2)		4 / 7
LEU A6852
THR A6989
LEU A6857
SER A6964
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 6
LEU A6883
ALA A6881
SER A6903
VAL B4295
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 6
LEU C6883
ALA C6881
SER C6903
VAL D4295
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 6
LEU A6883
ALA A6881
LEU A6893
VAL B4295
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU C7073
ALA C6858
LEU C7078
THR C7055
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wkq NSP16
(SARS-CoV-2)		4 / 7
LEU C6852
THR C6989
LEU C6857
SER C6964
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU C6893
ALA C6905
SER C6907
THR C6908
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wkq NSP16
(SARS-CoV-2)		4 / 7
LEU A6834
THR A6993
ALA A6843
THR A6846
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 6
LEU C6883
ALA C6881
LEU C6893
VAL D4295
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7078
THR A7055
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wkq NSP16
(SARS-CoV-2)		4 / 7
LEU C6834
THR C6993
ALA C6843
THR C6846
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LYS B  61
LEU B  58
ALA B  60
VAL B  10
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A 249
LEU A 246
SER A 288
THR A 282
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU B 249
LEU B 246
SER B 288
THR B 282
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
LEU A 249
LEU A 246
SER A 288
THR A 282
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LYS A  61
LEU A  58
ALA A  60
VAL A  10
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU B  43
ALA B  39
LEU B  75
VAL B  36
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU C  53
ALA C  39
SER C  65
VAL C  95
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU D  43
ALA D  39
LEU D  75
VAL D  36
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  43
ALA A  39
LEU A  75
VAL A  36
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU D  53
ALA D  39
SER D  65
VAL D  95
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU B  53
ALA B  39
SER B  65
VAL B  95
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  53
ALA A  39
SER A  65
VAL A  95
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 6
LEU A6883
ALA A6881
SER A6903
VAL B4295
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6834
THR A6993
ALA A6843
THR A6846
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7078
THR A7055
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 6
LEU A6883
ALA A6881
LEU A6893
VAL B4295
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6893
ALA A6905
SER A6907
THR A6908
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 6
LEU C  35
LEU C  55
SER C  10
VAL B  83
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wqd NSP7
(SARS-CoV-2)		4 / 6
LEU C  17
LEU C  14
SER C  10
VAL C  53
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wqd NSP7
(SARS-CoV-2)		4 / 7
THR A  45
ALA A  48
LEU A  40
SER A  10
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 6
LEU A  35
LEU A  55
SER A  10
VAL D  83
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wqd NSP7
(SARS-CoV-2)		4 / 7
THR C  46
ALA C  48
LEU C  40
SER C  10
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wqd NSP7
(SARS-CoV-2)		4 / 7
THR C  45
ALA C  48
LEU C  40
SER C  10
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU A  41
THR D  89
ALA D  86
THR D  84
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU C  41
THR B  89
ALA B  86
THR B  84
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6wqd NSP7
(SARS-CoV-2)		4 / 6
LEU A  17
LEU A  14
SER A  10
VAL A  53
1.48A
None
None
None
EDO  B 302 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6wqd NSP7
(SARS-CoV-2)		4 / 6
LYS A  51
ALA A  48
SER A   4
THR A  45
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
LEU A  87
THR A  25
LEU A  89
THR A  21
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
THR A 119
ALA A 116
LEU A 113
THR A 115
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
THR A 119
ALA A 116
SER A 111
THR A 115
1.59A
None
None
PO4  A 502 (-2.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
LEU A 117
THR A 168
ALA A 116
LEU A 118
1.08A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
LEU A 286
ALA A 285
LEU A 287
THR A 280
1.73A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
LEU A 205
THR A 224
ALA A 266
LEU A 268
1.53A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 286
ALA A 285
LEU A 287
THR A 280
1.73A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
LEU A 205
THR A 224
LEU A 242
THR A 226
1.79A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
LEU A  87
THR A  25
LEU A  89
THR A  21
1.63A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
LEU A 205
THR A 225
ALA A 266
LEU A 208
1.68A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
LEU A  35
LEU A  55
SER A  10
VAL D  83
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU C  41
THR B  89
ALA B  86
THR B  84
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
THR C  45
ALA C  48
LEU C  40
SER C  10
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU A  41
THR D  89
ALA D  86
THR D  84
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
LEU C  35
LEU C  55
SER C  10
VAL B  83
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
THR A  45
ALA A  48
LEU A  40
SER A  10
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
LEU A  17
LEU A  14
SER A  10
VAL A  53
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
LEU C  17
LEU C  14
SER C  10
VAL C  53
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 7
THR A  14
LEU A  64
SER A  65
THR A  17
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
LYS H 147
LEU H 145
SER H 184
VAL H 173
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 517
ALA E 522
LEU E 518
THR E 523
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
LEU H 142
THR H 139
ALA H 140
SER H 131
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 142
LEU L 181
SER L 168
VAL H 185
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 141
ALA H 141
SER L 120
VAL H 188
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 185
LEU L 187
SER L 188
THR L 135
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU C 142
THR C 178
SER C 168
THR C 170
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU C  11
THR C  80
ALA C  19
SER C  14
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU C  39
THR C  59
ALA C  57
SER C  73
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU C 142
LEU C 181
SER C 168
THR C 184
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
THR L 178
LEU L 141
SER L 182
THR L 170
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
LEU E 517
ALA E 522
LEU E 518
THR E 523
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU C 141
THR C 178
SER C 168
THR C 170
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU L  11
THR L  80
ALA L  19
SER L  14
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU C 142
LEU C 181
SER C 168
VAL B 185
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU C 141
ALA B 141
SER C 120
VAL B 188
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU C 185
LEU C 187
SER C 188
THR C 135
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 142
LEU L 181
SER L 168
THR L 184
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU L  39
THR L  59
ALA L  57
SER L  73
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU L 142
THR L 178
SER L 168
THR L 170
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU L 141
THR L 178
SER L 168
THR L 170
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 181
ALA L 150
LEU L 142
THR L 203
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU L 181
ALA L 150
LEU L 142
THR L 203
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
LEU H 128
THR H 187
ALA H 141
SER H 131
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 6
LYS H 147
LEU H 145
SER H 184
VAL H 173
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 142
LEU L 181
SER L 182
VAL L 138
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 142
LEU L 181
SER L 168
VAL H 185
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
LEU E 517
ALA E 522
LEU E 518
THR E 523
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 517
ALA E 522
LEU E 518
THR E 523
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU L  11
THR L  80
ALA L  19
SER L  14
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 141
ALA H 141
SER L 120
VAL H 188
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 142
LEU L 181
SER L 168
THR L 184
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU L  39
THR L  59
ALA L  57
SER L  73
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
LEU A 287
LEU A 286
SER A 284
THR A 280
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 286
ALA A 285
LEU A 287
THR A 280
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LYS A 137
ALA A 129
SER A 113
THR A 111
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU C 185
LEU C 187
SER C 188
THR C 135
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
THR C 178
LEU C 141
SER C 182
THR C 170
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
LEU B 142
THR B 139
ALA B 140
SER B 131
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU L 142
LEU L 181
SER L 168
VAL H 185
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU C 142
LEU C 181
SER C 168
VAL B 185
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 517
ALA E 522
LEU E 518
THR E 523
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
THR L 178
LEU L 141
SER L 182
THR L 170
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
LEU L  11
THR L  80
ALA L  19
SER L  14
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU L 141
ALA H 141
SER L 120
VAL H 188
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
LYS H 147
LEU H 145
SER H 184
VAL H 173
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
LEU L  39
THR L  59
ALA L  57
SER L  73
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU C 141
ALA B 141
SER C 120
VAL B 188
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
LYS B 147
LEU B 145
SER B 184
VAL B 173
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 517
ALA A 522
LEU A 518
THR A 523
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
LEU A 517
ALA A 522
LEU A 518
THR A 523
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
LEU H 142
THR H 139
ALA H 140
SER H 131
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
LEU E 517
ALA E 522
LEU E 518
THR E 523
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
LEU C  11
THR C  80
ALA C  19
SER C  14
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
LEU C  39
THR C  59
ALA C  57
SER C  73
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU L 142
LEU L 181
SER L 168
THR L 184
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU L 185
LEU L 187
SER L 188
THR L 135
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU C 142
LEU C 181
SER C 168
THR C 184
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
LEU A  87
THR A  25
LEU A  89
THR A  21
1.62A
None
PK8  A 401 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 286
ALA A 285
LEU A 287
THR A 280
1.73A
PEG  A 404 ( 3.6A)
None
PEG  A 404 (-2.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C  43
ALA C  39
LEU C  75
VAL C  36
1.67A
None
None
EPE  C 202 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A  43
ALA A  39
LEU A  75
VAL A  36
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C  53
ALA C  39
SER C  65
VAL C  95
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU E  53
ALA E  39
SER E  65
VAL E  95
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B  53
ALA B  39
SER B  65
VAL B  95
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B  43
ALA B  39
LEU B  75
VAL B  36
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU D  53
ALA D  39
SER D  65
VAL D  95
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU E  43
ALA E  39
LEU E  75
VAL E  36
1.66A
None
None
EPE  E 203 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A  53
ALA A  39
SER A  65
VAL A  95
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU D  53
ALA D  39
SER D  65
VAL D  95
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B  53
ALA B  39
SER B  65
VAL B  95
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C  53
ALA C  39
SER C  65
VAL C  95
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A  53
ALA A  39
SER A  65
VAL A  95
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A  43
ALA A  39
LEU A  75
VAL A  36
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU E  53
ALA E  39
SER E  65
VAL E  95
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B  53
ALA B  39
SER B  65
VAL B  95
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A  43
ALA A  39
LEU A  75
VAL A  36
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A  53
ALA A  39
SER A  65
VAL A  95
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C  43
ALA C  39
LEU C  75
VAL C  36
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B  43
ALA B  39
LEU B  75
VAL B  36
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C  53
ALA C  39
SER C  65
VAL C  95
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
LEU A  87
THR A  25
LEU A  89
THR A  21
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
LEU A 287
LEU A 286
SER A 284
THR A 280
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
LEU A 205
THR A 224
ALA A 266
LEU A 268
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 186
THR A 246
ALA A 250
THR A 252
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU B 128
ALA A 400
SER A 397
VAL A 405
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
ALA A 660
LEU A 663
SER A 664
VAL A 354
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 576
ALA A 580
SER A 578
THR A 582
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 186
THR A 248
ALA A 250
THR A 252
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
ALA A 660
LEU A 663
SER A 664
VAL A 535
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 387
ALA B 152
LEU B 128
THR B 148
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 372
THR A 538
ALA A 376
LEU A 371
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 931
ALA A 923
SER A 913
THR A 912
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7btf NSP7
(SARS-CoV-2)		4 / 6
LEU C  17
LEU C  14
SER C  10
VAL C  53
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 576
ALA A 580
SER A 578
THR A 582
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 387
ALA A 400
SER A 397
VAL A 405
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
ALA A 656
LEU A 663
SER A 664
VAL A 354
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LYS A 641
LEU A 575
LEU A 638
SER A 635
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 186
THR A 248
ALA A 250
THR A 246
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU B 103
LEU B  98
SER A 384
VAL A 398
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 251
ALA A 250
LEU A 316
THR A 248
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU B 103
ALA B 125
LEU B  98
SER A 384
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
LEU A 287
LEU A 286
SER A 284
THR A 280
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 251
ALA A 250
LEU A 316
THR A 248
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
LEU A 372
THR A 538
ALA A 376
LEU A 371
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 387
ALA B 152
LEU B 128
THR B 148
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LYS A 391
LEU A 389
LEU A 388
SER A 672
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 387
ALA A 400
SER A 397
VAL A 405
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7bv1 NSP7
(SARS-CoV-2)		4 / 6
LEU C  59
LEU C  13
SER C  10
THR C   9
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LYS A 391
LEU A 389
LEU A 388
SER A 672
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 401
ALA A 383
LEU A 673
VAL A 341
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 576
ALA A 580
SER A 578
THR A 582
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 245
ALA A 250
LEU A 316
THR A 252
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ALA A 660
LEU A 663
SER A 664
VAL A 535
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU B 128
ALA A 400
SER A 397
VAL A 405
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 245
ALA A 250
LEU A 316
THR A 252
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 576
ALA A 580
SER A 578
VAL A 587
1.68A
None
A  T  13 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 387
ALA B 150
LEU B 128
THR B 148
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 186
THR A 248
ALA A 250
THR A 252
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 251
ALA A 250
LEU A 316
THR A 248
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 387
ALA B 152
LEU B 128
THR B 148
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 7
LEU A 387
ALA B 152
LEU B 128
THR B 148
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7bv2 NSP7
(SARS-CoV-2)		4 / 6
LEU C  17
LEU C  14
SER C  10
VAL C  53
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU B 128
ALA A 400
SER A 397
VAL A 405
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ALA A 660
LEU A 663
SER A 664
VAL A 535
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ALA A 656
LEU A 663
SER A 664
VAL A 354
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 387
ALA A 400
SER A 397
VAL A 405
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 7
LEU A 387
ALA B 150
LEU B 128
THR B 148
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 186
THR A 248
ALA A 250
THR A 246
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 372
THR A 538
ALA A 376
LEU A 371
1.58A
None