Ligand ID: TCW


Drugbank ID:
DB00323
(Tolcapone)


Indication:
Used as an adjunct to levodopa/carbidopa therapy for the symptomatic treatment of Parkinson's Disease. This drug is generally reserved for patients with parkinsonian syndrome receiving levodopa/carbidopa who are experiencing symptom fluctuations and are not responding adequately to or are not candidates for other adjunctive therapies.

Get human targets for TCW in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'TCW' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		1wnc E2 GLYCOPROTEIN
(SARSr)		4 / 6
LYS F1172
ALA F1171
LEU F1167
THR F 921
1.45A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 6
LEU F 930
ALA F 926
LEU F 927
SER F 924
THR F 922
1.33A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU F 930
ALA F 926
LEU F 927
SER F 924
THR F 922
1.43A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		1wyy E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 6
LEU A 930
ALA A 926
LEU A 927
SER A 924
THR A 922
1.72A23.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		1wyy E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU A 930
ALA A 926
LEU A 927
SER A 924
THR A 922
1.68A23.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 6
LEU K  30
ALA K  26
LEU K  27
SER K  24
THR K  22
1.61A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU K  30
ALA K  26
LEU K  27
SER K  24
THR K  22
1.66A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B 202
ALA B 206
LEU B 205
VAL B 297
1.37A19.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU C 930
ALA C 926
LEU C 927
SER C 924
THR C 922
1.66A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 6
LEU C 930
ALA C 926
LEU C 927
SER C 924
THR C 922
1.61A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		2bez SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU C 930
ALA C 926
LEU C 927
SER C 924
THR C 922
1.73A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		2bez SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 6
LEU C 930
ALA C 926
LEU C 927
SER C 924
THR C 922
1.69A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU C  81
ALA C  69
LEU C  59
SER C  61
1.34A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
LYS C 293
LEU C 291
THR C 282
THR C 278
0.98A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU C  81
ALA C  69
LEU C  59
SER C  61
1.27A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 6
LEU A  66
ALA A  65
LEU A  66
SER A  67
1.13A27.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 6
LEU A  66
LEU A  66
SER A  67
VAL A  78
1.28A26.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 6
LEU A  66
ALA A  65
LEU A  66
SER A  67
1.10A26.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 6
LEU A  66
LEU A  66
SER A  67
THR A  68
1.39A27.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 202
ALA A 206
LEU A 205
VAL A 297
1.36A18.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2jzd REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU A 596
ALA A 631
LEU A 546
VAL A 633
1.33A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2kqv NSP3
(SARSr-CoV)		4 / 6
LEU A  74
ALA A 109
LEU A  24
VAL A 111
1.20A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.19A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.34A11.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.01A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 202
ALA A 206
LEU A 205
VAL A 297
1.38A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3e9s NSP3
(SARSr-CoV)		4 / 7
LYS A 293
LEU A 291
THR A 282
THR A 278
1.20A19.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B 202
ALA B 206
LEU B 205
VAL B 297
1.35A19.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 202
ALA A 206
LEU A 205
VAL A 297
1.35A19.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU A 202
ALA A 206
LEU A 205
VAL C 297
1.37A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 202
ALA A 206
LEU A 205
VAL A 297
1.39A18.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
LYS A 293
LEU A 291
THR A 282
THR A 278
1.03A19.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		3sci ACE2
(Homo
sapiens)		4 / 6
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.31A10.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
LYS A  68
LEU A  39
ALA A  65
SER A  44
1.03A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.25A10.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.34A11.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3v3m 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 202
ALA A 206
LEU A 205
VAL A 297
1.34A19.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		4m0w UBIQUITIN
(Bos
taurus)		4 / 6
LYS B  48
LEU B  50
ALA B  46
LEU B  67
1.24A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		4 / 6
LEU A  81
ALA A  69
LEU A  59
SER A  61
1.32A19.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 6
LYS A 291
ALA A 282
LEU A 284
VAL A 268
1.01A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 6
LEU A 113
ALA A 115
LEU A 104
SER A 103
1.28A18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
LEU D 109
THR D 122
ALA D 119
LEU D 117
1.01A16.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
LEU D 109
THR D 122
ALA D 119
LEU D 117
1.04A14.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
LYS D 293
LEU D 291
THR D 282
THR D 278
0.98A19.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 7
LEU A 109
THR A 122
ALA A 119
LEU A 117
1.05A12.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
LEU B  81
ALA B  69
LEU B  59
SER B  61
1.14A19.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
LYS B 293
LEU B 291
THR B 282
THR B 278
1.07A19.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		5tl7 UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus)		4 / 6
LEU C 105
LEU C 122
SER C 123
THR C 145
1.32A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 7
LEU C 745
THR B 991
LEU C 986
SER C 985
THR C 988
1.76A8.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		5x5c S PROTEIN
(MERS-CoV)		4 / 6
ALA B 760
LEU B 722
SER B 721
VAL B 714
1.39A6.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5x5f S PROTEIN
(MERS-CoV)		4 / 7
THR B 669
ALA B 671
LEU B 673
SER B 660
0.84A6.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU A 636
ALA A 595
LEU A 597
SER A 582
1.09A7.56
LEU  A 636 ( 0.6A)
ALA  A 595 ( 0.0A)
LEU  A 597 ( 0.6A)
SER  A 582 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
LEU A 636
ALA A 595
LEU A 597
SER A 582
1.12A7.56
LEU  A 636 ( 0.6A)
ALA  A 595 ( 0.0A)
LEU  A 597 ( 0.6A)
SER  A 582 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU A 636
ALA A 595
LEU A 597
SER A 582
0.72A7.56
LEU  A 636 ( 0.6A)
ALA  A 595 ( 0.0A)
LEU  A 597 ( 0.6A)
SER  A 582 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
LYS A 293
LEU A 291
THR A 282
THR A 278
1.16A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		5zvm SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 7
LEU B 930
ALA B 926
LEU B 927
SER B 924
THR B 922
1.70A22.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		5zvm SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 6
LEU B 930
ALA B 926
LEU B 927
SER B 924
THR B 922
1.70A22.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6acg ACE2
(Homo
sapiens)		4 / 6
ALA D 396
LEU D 560
SER D 563
VAL D 209
1.35A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
LEU B 597
ALA B 633
LEU B 636
THR B 631
0.83A7.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU A 636
ALA A 595
LEU A 597
SER A 582
0.94A7.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU A 636
ALA A 595
LEU A 597
SER A 582
0.75A7.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
LEU B 636
ALA B 595
LEU B 597
SER B 582
0.73A7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
LEU B 636
ALA B 595
LEU B 597
SER B 582
1.07A7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
LEU B 636
ALA B 595
LEU B 597
SER B 582
0.95A7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
LEU B 636
ALA B 595
LEU B 597
SER B 582
0.94A7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
LEU B 636
ALA B 595
LEU B 597
SER B 582
0.64A7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6m18 ACE2
(Homo
sapiens)		4 / 6
LYS D  68
LEU D  39
ALA D  65
SER D  44
1.21A9.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6m18 ACE2
(Homo
sapiens)		4 / 6
LYS D  68
LEU D  39
ALA D  65
SER D  44
0.97A9.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6m18 ACE2
(Homo
sapiens)		4 / 7
LYS D  68
LEU D  39
ALA D  65
SER D  44
1.04A9.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU A 636
ALA A 595
LEU A 597
SER A 582
1.06A7.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
LEU C 636
ALA C 595
LEU C 597
SER C 582
0.90A7.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 140
ALA H 151
SER H 146
THR H 149
1.17A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		4 / 7
LEU H  11
THR H  91
ALA H 124
THR H 122
1.21A19.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6nur NSP12
(SARSr-CoV)		4 / 6
LEU A 387
ALA A 400
SER A 397
VAL A 405
1.38A9.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6nur NSP7
(SARSr-CoV)		4 / 6
LEU C  17
LEU C  14
SER C  10
VAL C  53
1.36A23.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6nur NSP12
(SARSr-CoV)		4 / 6
LYS A 641
LEU A 575
LEU A 638
SER A 635
1.33A8.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6vw1 ACE2
(Homo
sapiens)		4 / 6
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.10A10.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6vw1 ACE2
(Homo
sapiens)		4 / 7
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.24A10.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6vw1 ACE2
(Homo
sapiens)		4 / 6
LYS B  68
LEU B  39
ALA B  65
SER B  44
1.33A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
LEU L 135
ALA H 137
SER L 114
VAL H 184
1.34A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
LEU L 136
LEU L 175
SER L 162
VAL H 181
1.57A22.16
None
None
GOL  L 301 (-3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
LEU H  18
THR H 108
LEU H  82
THR H  87
1.78A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
LYS H 143
LEU H 141
SER H 180
VAL H 169
1.68A24.68
None
None
None
GOL  L 301 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
LEU H 189
ALA H 136
SER H 132
THR H 131
1.63A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
ALA H 137
LEU L 135
SER L 114
VAL H 184
1.64A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
LEU L 135
ALA H 137
SER L 114
THR H 135
1.59A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
LEU H 189
ALA H 136
SER H 132
THR H 131
1.63A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
THR H 108
ALA H  88
SER H  85
THR H  87
1.72A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
LEU H 138
THR H 135
ALA H 136
SER H 127
1.68A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
LEU H 124
THR H 183
ALA H 137
SER H 127
1.58A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
LYS H 143
LEU H 141
LEU H 124
VAL H 169
1.72A24.68
None
None
None
GOL  L 301 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
LEU L  73
ALA L  19
SER L  76
VAL L  13
1.62A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
LEU H 138
THR H 135
ALA H 137
LEU H 124
1.55A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
LEU H  18
THR H   9
LEU H  82
THR H 110
1.65A24.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
LEU L 135
ALA H 137
SER L 114
THR H 135
1.56A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
LYS H 147
LEU H 145
SER H 184
VAL H 173
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
LEU H 142
THR H 139
ALA H 140
SER H 131
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 142
LEU L 181
SER L 168
VAL H 185
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 141
ALA H 141
SER L 120
VAL H 188
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 185
LEU L 187
SER L 188
THR L 135
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU C 142
THR C 178
SER C 168
THR C 170
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU C  11
THR C  80
ALA C  19
SER C  14
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU C  39
THR C  59
ALA C  57
SER C  73
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU C 142
LEU C 181
SER C 168
THR C 184
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
THR L 178
LEU L 141
SER L 182
THR L 170
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU C 141
THR C 178
SER C 168
THR C 170
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU L  11
THR L  80
ALA L  19
SER L  14
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU C 142
LEU C 181
SER C 168
VAL B 185
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU C 141
ALA B 141
SER C 120
VAL B 188
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU C 185
LEU C 187
SER C 188
THR C 135
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 142
LEU L 181
SER L 168
THR L 184
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU L  39
THR L  59
ALA L  57
SER L  73
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU L 142
THR L 178
SER L 168
THR L 170
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU L 141
THR L 178
SER L 168
THR L 170
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 181
ALA L 150
LEU L 142
THR L 203
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU L 181
ALA L 150
LEU L 142
THR L 203
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
LEU H 128
THR H 187
ALA H 141
SER H 131
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 6
LYS H 147
LEU H 145
SER H 184
VAL H 173
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 142
LEU L 181
SER L 182
VAL L 138
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 142
LEU L 181
SER L 168
VAL H 185
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU L  11
THR L  80
ALA L  19
SER L  14
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 141
ALA H 141
SER L 120
VAL H 188
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L 142
LEU L 181
SER L 168
THR L 184
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
LEU L  39
THR L  59
ALA L  57
SER L  73
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU C 185
LEU C 187
SER C 188
THR C 135
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
THR C 178
LEU C 141
SER C 182
THR C 170
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
LEU B 142
THR B 139
ALA B 140
SER B 131
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU L 142
LEU L 181
SER L 168
VAL H 185
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU C 142
LEU C 181
SER C 168
VAL B 185
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
THR L 178
LEU L 141
SER L 182
THR L 170
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
LEU L  11
THR L  80
ALA L  19
SER L  14
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU L 141
ALA H 141
SER L 120
VAL H 188
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
LYS H 147
LEU H 145
SER H 184
VAL H 173
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
LEU L  39
THR L  59
ALA L  57
SER L  73
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU C 141
ALA B 141
SER C 120
VAL B 188
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
LYS B 147
LEU B 145
SER B 184
VAL B 173
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
LEU H 142
THR H 139
ALA H 140
SER H 131
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
LEU C  11
THR C  80
ALA C  19
SER C  14
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
LEU C  39
THR C  59
ALA C  57
SER C  73
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU L 142
LEU L 181
SER L 168
THR L 184
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU L 185
LEU L 187
SER L 188
THR L 135
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU C 142
LEU C 181
SER C 168
THR C 184
1.78A
None