Ligand ID: SAS


Drugbank ID:
DB00795
(Sulfasalazine)


Indication:
For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.

Get human targets for SAS in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'SAS'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
SER A 123
PHE A 140
TYR A 118
GLY B   2
LEU B   0
1.63A23.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.21A23.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU B  88
CYH B  73
PHE B  90
GLY A 100
LEU A  97
1.67A17.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B1262
CYH B1265
ALA B1206
GLY B1251
LEU B1250
1.69A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B1177
MET B1162
ASP B1153
1.15A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER C  19
LEU E  20
ALA C  26
GLY E  28
LEU E  27
1.67A13.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.22A23.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
LEU A 264
CYH A 263
ASP A 249
ASP D 352
MET D 348
1.52A22.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
LEU A 264
CYH A 263
ASP A 249
ASP D 352
MET D 348
1.51A22.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 10
PRO F 121
VAL F 120
ARG F 116
VAL B  63
GLY B  69
1.35A21.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		3 / 3
LEU C  18
MET C  57
ASP C  72
1.16A18.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 9
PRO F 121
VAL F 120
ARG F 116
VAL B  63
GLY B  69
1.35A21.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2ajf ACE2
(Homo
sapiens)		5 / 12
SER A 420
LEU A 418
PHE A 369
GLN A 300
ASP A 368
1.66A21.22
NAG  A1546 (-3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2ajf ACE2
(Homo
sapiens)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.37A21.22
 CL  A 902 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		2ajf ACE2
(Homo
sapiens)		5 / 12
SER A 420
LEU A 418
PHE A 369
GLN A 300
ASP A 368
1.68A21.22
NAG  A1546 (-3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2ajf ACE2
(Homo
sapiens)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.37A21.22
 CL  A 902 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.52A23.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.56A23.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH B 128
PHE B 112
TYR B 126
ASP B 176
GLY B 174
1.49A24.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH B 128
PHE B 112
TYR B 126
ASP B 176
GLY B 174
1.52A24.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.14A24.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2amq 3C-LIKE
PROTEINASE

(SARSr-CoV;
synthetic
construct)		5 / 12
PHE B 181
PRO B  52
ALA D   2
MET B 165
LEU D   4
1.48A24.57
None
None
02J  D   1 ( 3.6A)
None
PJE  D   5 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER C 919
LEU A 920
ALA C 926
GLY A 928
LEU A 927
1.67A9.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2bx4 3C-LIKE PROTEINASE
(SARS-COV
Sin2774)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.44A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2bx4 3C-LIKE PROTEINASE
(SARS-COV
Sin2774)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.40A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
LEU D 353
PHE D 287
PRO D 303
ALA C 312
GLY D 296
1.37A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
LEU D 353
PHE D 287
PRO D 303
ALA C 312
GLY D 296
1.34A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		4 / 7
SER H 179
TYR L 179
PRO H 167
PHE L 119
1.50A22.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 10
PHE C 133
VAL C  50
ILE B 132
PRO C 137
GLY C 131
1.68A25.11
None
None
APR  B 477 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 9
PHE C 133
VAL C  50
ILE B 132
PRO C 137
GLY C 131
1.68A25.11
None
None
APR  B 477 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU C 260
CYH C 261
GLN C 122
GLY C 101
LEU C 102
1.59A22.48
 BR  C 317 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
LEU N  45
MET I  63
ASP M  64
1.27A17.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
TYR C 383
TYR C 410
GLU C 502
PRO C 413
1.74A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU A 499
PHE A 501
TYR A 367
ALA A 371
LEU A 374
1.69A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
LEU B 353
PHE B 287
PRO B 303
ALA A 312
GLY B 296
1.48A12.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
SER A 319
PHE B 287
ASP B 289
ASP B 291
GLY B 296
1.61A12.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2gri NSP3
(SARSr)		3 / 3
LEU A  90
MET A 103
ASP A  29
0.77A18.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
SER A 144
TYR A 118
GLU A 166
PHE A 140
1.66A16.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.50A23.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		2idy NSP3
(SARSr-CoV)		4 / 7
TYR A  19
GLU A  46
PRO A   2
PHE A  99
1.18A22.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
SER B 319
PHE A 287
ASP A 289
ASP A 291
GLY A 296
1.62A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		5 / 9
PRO A  74
VAL A  73
ILE A  -3
TYR A 124
GLY A  86
1.54A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		5 / 10
PRO A  74
VAL A  73
ILE A  -3
TYR A 124
GLY A  86
1.54A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.14A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.47A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.50A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2q6g POLYPEPTIDE CHAIN
REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
PHE B 181
PRO B  52
ALA D   3
MET B 165
LEU D   5
1.57A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.17A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.49A23.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.52A23.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.41A23.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
SER E 261
LEU E 263
PHE E 240
ASP E 239
GLY E 243
1.65A24.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 10
TYR A 278
PHE A 268
PRO A 270
VAL B  10
ILE A 295
1.70A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.18A23.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		2wct NSP3
(SARSr-CoV)		5 / 12
CYH D 456
PHE D 436
GLN D 426
ASP D 433
MET D 434
1.79A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		2xyq NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 10
PRO A  80
VAL B  42
VAL A 104
ILE B  99
GLY B  69
1.75A21.16
SAH  A1293 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		3 / 3
LEU A 206
MET A 184
ASP A 144
1.12A23.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		2xyq NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 9
PRO A  80
VAL B  42
VAL A 104
ILE B  99
GLY B  69
1.75A21.16
SAH  A1293 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		2xyr NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 10
PRO A  80
VAL B  42
VAL A 104
ILE B  99
GLY B  69
1.75A21.16
SFG  A1298 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		2xyr NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 9
PRO A  80
VAL B  42
VAL A 104
ILE B  99
GLY B  69
1.75A21.16
SFG  A1298 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		3 / 3
LEU A 206
MET A 184
ASP A 144
1.09A23.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
SER L  34
LEU L  36
PHE L  98
TRP L  96
TYR L  91
1.76A22.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
LEU B 100
TYR B  32
ALA B  24
GLY B 104
LEU B   4
1.62A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
LEU B 176
MET B 123
ASP B 269
1.28A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.42A21.35
 CL  A 902 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		3d0g ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
TYR A  34
TYR E 484
TYR E 481
PRO E 493
1.67A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.41A21.35
 CL  A 902 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A 456
SER A 507
LEU A 176
ASP A 494
MET A 474
1.80A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER E 358
LEU E 355
PHE E 329
ALA E 422
ASP E 385
1.43A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3d0i SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER E 358
LEU E 355
PHE E 329
ALA E 422
ASP E 385
1.51A18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		3d0i SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
SER E 500
TYR E 383
GLU E 502
PHE E 416
1.33A22.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.49A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.08A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.52A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		3e9s NSP3
(SARSr-CoV)		5 / 12
LEU A 260
CYH A 261
GLN A 122
GLY A 101
LEU A 102
1.63A23.21
 CL  A 320 (-4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH B 128
PHE B 112
TYR B 126
ASP B 176
GLY B 174
1.46A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH B 128
PHE B 112
TYR B 126
ASP B 176
GLY B 174
1.50A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.37A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.56A23.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
SER A  35
LEU A   4
ALA B 107
MET A 101
GLY B 100
1.33A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
SER A  35
LEU A   4
ALA B 107
MET A 101
GLY B 100
1.27A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.19A24.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3i6g HLA, A-2
(Homo
sapiens)		3 / 3
LEU A 272
MET A 189
ASP A 183
1.19A19.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH B 128
PHE B 112
TYR B 126
ASP B 176
GLY B 174
1.47A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.33A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH B 128
PHE B 112
TYR B 126
ASP B 176
GLY B 174
1.50A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		3r24 NSP10 AND NSP11
(SARSr-CoV)		5 / 10
PRO B 107
VAL B 108
VAL B  97
ILE B  81
TYR B  76
1.78A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		3r24 NSP10 AND NSP11
(SARSr-CoV)		5 / 9
PRO B 107
VAL B 108
VAL B  97
ILE B  81
TYR B  76
1.78A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		5 / 9
PRO A  80
VAL B  42
VAL A 104
ILE B  99
GLY B  69
1.72A21.56
SAM  A 302 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		5 / 10
PRO A  80
VAL B  42
VAL A 104
ILE B  99
GLY B  69
1.72A21.56
SAM  A 302 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		3 / 3
LEU A 206
MET A 184
ASP A 144
1.15A25.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
SER F 336
TYR F 438
TYR F 440
PHE F 387
1.69A22.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.41A21.48
 CL  A 902 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.40A21.48
 CL  A 902 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
LEU B 176
MET B 123
ASP B 269
1.31A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
TYR A 385
GLU A 564
PRO A 389
PHE A 400
1.76A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.55A23.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.52A23.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3v3m 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.11A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		3vb6 3C-LIKE PROTEINASE
C6Z INHIBITOR
(SARSr-CoV)		5 / 12
PHE A 181
PRO A  52
ALA E   4
MET A 165
LEU E   6
1.47A23.87
None
None
None
None
0JU  E   7 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.48A23.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.15A23.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.45A23.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A 260
CYH A 261
GLN A 122
GLY A 101
LEU A 102
1.61A23.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.51A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.55A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 12
LEU A 260
CYH A 261
GLN A 122
GLY A 101
LEU A 102
1.54A23.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.00A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		4wy3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.48A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		4wy3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.51A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.48A24.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.12A24.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.46A24.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
SER D 407
LEU D 406
TYR D 420
PRO D 412
GLY D 416
1.63A20.83
None
None
G3A  D 606 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
LEU D 495
SER D 470
CYH D 473
TYR D 491
MET D 315
1.79A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
SER D 407
LEU D 406
TYR D 420
PRO D 412
GLY D 416
1.65A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
TYR D 138
TYR D  72
GLU A 135
PRO A 131
1.79A16.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU D 260
CYH D 261
GLN D 122
GLY D 101
LEU D 102
1.59A23.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
SER M  15
LEU M  14
PHE A   8
PRO M   8
ASP A  10
1.64A17.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.14A19.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A  30
MET A  17
ASP A 187
1.51A19.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.50A19.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU B 260
CYH B 261
GLN B 122
GLY B 101
LEU B 102
1.56A23.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
PHE C 700
PRO C1051
VAL C1050
VAL C 893
ILE C 704
1.55A10.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
PHE C 700
PRO C1051
VAL C1050
VAL C 893
ILE C 704
1.55A10.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
SER B1151
LEU B 780
TYR B1153
GLN B 772
GLY C 953
1.66A12.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
LEU B 673
PRO B 658
ALA B 678
MET C 906
GLY C 904
1.50A12.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
LEU B 673
PRO B 658
ALA B 678
MET C 906
GLY C 904
1.47A12.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
PHE C  47
PRO B 547
GLN B 550
ASP B 560
ASP B 572
1.34A12.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
PHE C  47
PRO B 547
GLN B 550
ASP B 560
ASP B 572
1.31A12.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		5x5f S PROTEIN
(MERS-CoV)		3 / 3
LEU A 938
MET A 939
ASP C 664
1.27A12.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		5x5f S PROTEIN
(MERS-CoV)		4 / 7
SER B1151
TYR B1153
TYR B1171
PHE C 967
1.69A6.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER A 949
LEU A 948
PHE B 558
GLN A 818
ASP B 572
1.61A12.97
SER  A 949 ( 0.0A)
LEU  A 948 ( 0.6A)
PHE  B 558 ( 1.3A)
GLN  A 818 ( 0.6A)
ASP  B 572 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
TYR C 383
SER C 346
GLU C 502
PRO C 507
1.58A7.57
TYR  C 383 ( 1.3A)
SER  C 346 ( 0.0A)
GLU  C 502 ( 0.6A)
PRO  C 507 ( 1.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A 260
CYH A 261
GLN A 122
GLY A 101
LEU A 102
1.54A23.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		4 / 7
TYR a  36
SER a  35
GLU a  33
PHE A 909
1.79A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU C 983
LEU C 736
TYR C 738
GLN C 744
ASP C 719
1.66A12.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6acj ACE2
(Homo
sapiens)		5 / 12
LEU D  79
LEU D  73
PHE D  32
GLN D 101
ASP D  30
1.58A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6acj ACE2
(Homo
sapiens)		3 / 3
LEU D 176
MET D 123
ASP D 269
1.22A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
TYR C 383
SER C 346
GLU C 502
PRO C 507
1.37A7.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER A 358
LEU A 355
PHE A 329
ALA A 422
ASP A 385
1.43A12.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
PHE A 700
PRO A1051
VAL A1050
VAL A 893
ILE A 704
1.72A10.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU A 216
SER A  35
PRO A 210
GLN A 201
ASP A 274
1.72A12.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
PHE A 700
PRO A1051
VAL A1050
VAL A 893
ILE A 704
1.72A10.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
SER B 500
TYR B 410
TYR B 383
GLU B 502
1.55A6.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
PHE B 700
PRO B1051
VAL B1050
VAL B 893
ILE B 704
1.70A9.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER B 957
LEU B 948
PHE A 558
ASP A 560
ASP A 554
1.58A13.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
PHE B 700
PRO B1051
VAL B1050
VAL B 893
ILE B 704
1.70A9.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER B 957
LEU B 948
PHE A 558
ASP A 560
ASP A 554
1.57A13.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
LEU A  52
MET A 263
ASP A 296
1.23A13.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6cs2 ACE2
(Homo
sapiens)		5 / 12
SER D 502
LEU D 503
PHE D 452
ALA D 264
GLY D 268
1.45A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
LEU A 168
MET A   5
ASP A 177
1.16A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6jyt HELICASE
(SARSr-CoV)		5 / 12
LEU A 384
PHE A 373
TYR A 396
ASP A 374
GLY A 400
1.63A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6jyt HELICASE
(SARSr-CoV)		5 / 12
SER A  13
LEU A  92
MET A  68
GLY A  67
LEU A  65
1.56A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6jyt HELICASE
(SARSr-CoV)		4 / 7
SER A 555
TYR A 515
GLU A 551
PHE A 546
1.70A11.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.52A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
LEU A  30
MET A  17
ASP A 187
1.51A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.49A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
TYR B 423
PRO B 426
ILE B 434
PRO B 412
GLY B 431
1.64A23.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6m0j ACE2
(Homo
sapiens)		4 / 7
TYR A 385
GLU A 564
PRO A 389
PHE A 400
1.73A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6m0j ACE2
(Homo
sapiens)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.43A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6m0j ACE2
(Homo
sapiens)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.42A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6m0j SPIKE RECEPTOR
BINDING DOMAIN
(SARS-CoV-2)		4 / 7
TYR E 396
SER E 359
GLU E 516
PRO E 521
1.20A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.49A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.37A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.52A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
LEU A  30
MET A  17
ASP A 187
1.53A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 7
TYR A 139
SER A 143
PRO A 147
PHE A 421
1.57A12.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6m17 ACE2
(Homo
sapiens)		3 / 3
LEU D 558
MET D 557
ASP D 543
1.15A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6m17 ACE2
(Homo
sapiens)		5 / 12
SER D 502
LEU D 503
PHE D 452
ALA D 264
GLY D 268
1.49A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6m17 ACE2
(Homo
sapiens)		5 / 12
SER D 502
LEU D 503
PHE D 452
ALA D 264
GLY D 268
1.48A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LEU A  61
CYH A  62
PHE A  70
TYR A 322
GLY A 311
1.54A16.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LEU A  61
CYH A  62
PHE A  70
TYR A 322
GLY A 311
1.55A16.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6m1d ACE2
(Homo
sapiens)		4 / 7
SER B 611
GLU B 489
PRO B 263
PHE B 684
1.20A8.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 10
PRO C 442
VAL C 441
VAL C 103
ILE C 216
GLY C 285
1.43A16.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 9
PRO C 442
VAL C 441
VAL C 103
ILE C 216
GLY C 285
1.43A16.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
CYH C 128
PHE C 112
TYR C 126
ASP C 176
GLY C 174
1.53A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
CYH C 128
PHE C 112
TYR C 126
ASP C 176
GLY C 174
1.50A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.58A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
CYH D 128
PHE D 112
TYR D 126
ASP D 176
GLY D 174
1.51A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU A  30
MET A  17
ASP A 187
1.52A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
CYH D 128
PHE D 112
TYR D 126
ASP D 176
GLY D 174
1.54A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
CYH B 128
PHE B 112
TYR B 126
ASP B 176
GLY B 174
1.56A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
CYH B 128
PHE B 112
TYR B 126
ASP B 176
GLY B 174
1.53A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU D  30
MET D  17
ASP D 187
1.44A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU C  30
MET C  17
ASP C 187
1.46A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.55A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU C 177
MET C 162
ASP C 153
1.55A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.16A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.53A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU A  30
MET A  17
ASP A 187
1.50A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.49A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
PRO B  74
VAL B  73
ARG B  69
TYR B 124
GLY B  86
1.59A19.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
PRO B  74
VAL B  73
ARG B  69
TYR B 124
GLY B  86
1.59A19.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		6 / 10
TYR A 653
VAL A 535
ARG A 533
VAL A 353
PRO A 537
GLY A 345
1.54A13.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 205
LEU A 245
PHE A 287
TYR A 237
ASP A 284
1.80A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		5 / 10
PHE A 429
VAL A 435
VAL A 424
ILE A 837
TYR A 884
1.74A13.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		5 / 9
VAL A 535
ARG A 533
VAL A 353
PRO A 537
GLY A 345
1.43A13.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 731
LEU A 207
PHE A  45
TYR A 732
PRO A 243
1.74A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		5 / 9
PHE A 429
VAL A 435
VAL A 424
ILE A 837
TYR A 884
1.74A13.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
SER A 500
TYR A 383
GLU A 502
PHE A 416
1.75A6.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6nur NSP12
NSP8
(SARSr-CoV)		3 / 3
LEU B  91
MET B  90
ASP A 523
1.37A23.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6nur NSP12
(SARSr-CoV)		5 / 12
LEU A 205
LEU A 245
PHE A 287
TYR A 237
ASP A 284
1.66A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6nus NSP12
(SARSr-CoV)		5 / 9
VAL A 535
ARG A 533
VAL A 353
PRO A 537
GLY A 345
1.38A12.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6nus NSP12
(SARSr-CoV)		6 / 10
TYR A 653
VAL A 535
ARG A 533
VAL A 353
PRO A 537
GLY A 345
1.53A12.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
TYR B  91
SER B 205
GLU B 191
PHE B 194
1.71A6.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU B 560
PHE C  43
GLN B 564
ASP B 574
ASP B 586
1.49A11.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU B 560
PHE C  43
GLN B 564
ASP B 574
ASP B 586
1.48A11.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
TYR E 396
SER E 359
GLU E 516
PRO E 521
1.52A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER F 371
LEU F 368
PHE F 342
ALA F 435
ASP F 398
1.50A20.98
None
None
NAG  F 601 (-4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6vw1 ACE2
(Homo
sapiens)		3 / 3
LEU A 176
MET A 123
ASP A 269
1.21A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6vw1 ACE2
(Homo
sapiens)		4 / 7
TYR B 385
GLU B 564
PRO B 389
PHE B 400
1.78A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B 201
PHE B 264
TYR B 279
ASP B 283
GLY B 239
1.66A23.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A 201
PHE A 264
TYR A 279
GLY A 239
LEU A 249
1.57A23.75
ACY  A 406 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
TYR C 266
TYR C 269
TYR C  91
PHE C  65
1.73A6.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 560
PHE C 565
PRO A  39
ASP C 574
ASP C 568
1.56A13.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
TYR A 266
TYR A 269
TYR A  91
PHE A  65
1.76A6.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU B 699
MET C 869
ASP B1041
1.41A13.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 9
PRO C  73
VAL C  72
ARG C  68
TYR C 123
GLY C  85
1.58A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 10
PRO C  73
VAL C  72
ARG C  68
TYR C 123
GLY C  85
1.58A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
TYR B 180
TYR B 179
PRO B  68
PHE B 135
1.79A14.96
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
TYR L  92
SER H  99
TYR L  91
PRO H 100
1.76A37.20
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		4 / 7
TYR H  27
TYR H  32
TYR C 369
PRO C 384
1.69A35.61
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER H  99
TYR L  27
TYR C 380
PRO C 412
1.59A35.61
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
TYR H  90
TYR H  91
PRO L  44
PHE H  63
1.37A35.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
SER C 349
TYR C 451
TYR C 453
PHE C 400
1.73A22.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
TYR C 396
SER C 359
GLU C 516
PRO C 521
1.28A22.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6w4b NSP9
(SARS-CoV-2)		3 / 3
LEU B 104
MET A 102
ASP B  79
1.37A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6w4b NSP9
(SARS-CoV-2)		5 / 12
LEU B  89
CYH B  74
PHE B  91
GLY A 101
LEU A  98
1.64A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6w4h NSP10
NSP16
(SARS-CoV-2)		5 / 10
PRO A6878
VAL B4295
VAL A6902
ILE B4352
GLY B4322
1.77A22.04
SAM  A7102 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6w4h NSP10
NSP16
(SARS-CoV-2)		5 / 9
PRO A6878
VAL B4295
VAL A6902
ILE B4352
GLY B4322
1.77A22.04
SAM  A7102 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6w4h NSP16
(SARS-CoV-2)		3 / 3
LEU A7004
MET A6982
ASP A6942
1.33A24.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 10
PRO A6878
VAL B4295
VAL A6902
ILE B4352
GLY B4322
1.79A
SAM  A7104 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
PRO A6878
VAL B4295
VAL A6902
ILE B4352
GLY B4322
1.79A
SAM  A7104 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
LEU A7004
MET A6982
ASP A6942
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.47A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A  30
MET A  17
ASP A 187
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.50A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
SER A 139
PHE A 116
PRO A  98
ALA A  38
GLY A  79
1.77A
None
None
None
AMP  A 201 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
SER B 139
PHE B 116
PRO B  98
ALA B  38
GLY B  79
1.79A
None
None
None
MES  B 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
LEU A7004
MET A6982
ASP A6942
1.34A18.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 10
PRO C6878
VAL D4295
VAL C6902
ILE D4352
GLY D4322
1.77A23.08
SAM  C7105 ( 3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 9
PRO A6878
VAL B4295
VAL A6902
ILE B4352
GLY B4322
1.78A23.08
SAM  A7102 ( 3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER A7041
LEU A7042
GLN A6885
ASP A6928
GLY A6879
1.73A18.82
None
None
None
SAM  A7102 ( 3.7A)
SAM  A7102 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
LEU A6834
MET A6840
ASP A7044
1.31A18.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C7039
LEU C7042
PRO C6805
ALA C6997
ASP C6928
1.72A18.82
FMT  C7111 ( 3.2A)
None
None
None
SAM  C7105 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
LEU C7004
MET C6982
ASP C6942
1.17A18.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 10
PRO A6878
VAL B4295
VAL A6902
ILE B4352
GLY B4322
1.78A23.08
SAM  A7102 ( 3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 9
PRO C6878
VAL D4295
VAL C6902
ILE D4352
GLY D4322
1.77A23.08
SAM  C7105 ( 3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER A7039
LEU A7042
PRO A6805
ALA A6997
ASP A6928
1.76A18.82
None
None
None
None
SAM  A7102 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C 125
PHE C 127
GLN C 121
ALA C 139
LEU C 117
1.45A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B 125
PHE B 127
GLN B 121
ALA B 139
LEU B 117
1.56A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
TYR C 296
GLU C 263
PRO C 248
PHE C 258
1.58A16.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 125
PHE A 127
GLN A 121
ALA A 139
LEU A 117
1.53A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		5 / 12
SER A 139
PHE A 116
PRO A  98
ALA A  38
GLY A  79
1.79A
None
None
None
MES  A 201 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wen NSP3
(SARS-CoV-2)		5 / 12
SER A 139
PHE A 116
PRO A  98
ALA A  38
GLY A  79
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6wey NSP3
(SARS-CoV-2)		5 / 12
SER A 343
PHE A 320
PRO A 302
ALA A 242
GLY A 283
1.78A21.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 297
CYH A 296
PRO A 329
ALA A 254
GLY A 301
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wey NSP3
(SARS-CoV-2)		5 / 12
SER A 343
PHE A 320
PRO A 302
ALA A 242
GLY A 283
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU F 352
PHE F 286
PRO F 302
ALA E 311
GLY F 295
1.38A
None
None
None
CL  F 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU E 352
PHE E 286
PRO E 302
ALA F 311
GLY E 295
1.40A
None
None
None
CL  E 401 ( 4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU F 352
PHE F 286
PRO F 302
ALA E 311
GLY F 295
1.41A16.38
None
None
None
CL  F 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU B 353
PHE B 307
ALA B 336
ASP B 340
GLY A 328
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU B 352
PHE B 286
PRO B 302
ALA A 311
GLY B 295
1.44A16.38
None
None
None
CL  B 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU E 352
PHE E 286
PRO E 302
ALA F 311
GLY E 295
1.44A16.38
None
None
None
CL  E 401 ( 4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU C 352
PHE C 286
PRO C 302
ALA D 311
GLY C 295
1.42A16.38
None
None
None
CL  C 401 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU A 352
PHE A 286
PRO A 302
ALA B 311
GLY A 295
1.39A
None
None
None
CL  A 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU C 352
PHE C 286
PRO C 302
ALA D 311
GLY C 295
1.38A
None
None
None
CL  C 401 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU E 353
PHE E 307
ALA E 336
ASP E 340
GLY F 328
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU D 352
PHE D 286
PRO D 302
ALA C 311
GLY D 295
1.39A
None
None
None
CL  D 401 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU D 353
PHE D 307
ALA D 336
ASP D 340
GLY C 328
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU A 352
PHE A 286
PRO A 302
ALA B 311
GLY A 295
1.43A16.38
None
None
None
CL  A 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU B 352
PHE B 286
PRO B 302
ALA A 311
GLY B 295
1.41A
None
None
None
CL  B 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU D 352
PHE D 286
PRO D 302
ALA C 311
GLY D 295
1.43A16.38
None
None
None
CL  D 401 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A7041
LEU A7042
GLN A6885
ASP A6928
GLY A6879
1.74A24.48
None
None
None
SAH  A7102 (-3.7A)
SAH  A7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 10
PRO C6878
VAL D4295
VAL C6902
ILE D4352
GLY D4322
1.77A
SAH  C7102 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
PRO C6878
VAL D4295
VAL C6902
ILE D4352
GLY D4322
1.77A
SAH  C7102 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
LEU A6834
MET A6840
ASP A7044
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 10
PRO A6878
VAL B4295
VAL A6902
ILE B4352
GLY B4322
1.78A
SAH  A7102 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
LEU C7004
MET C6982
ASP C6942
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
PRO A6878
VAL B4295
VAL A6902
ILE B4352
GLY B4322
1.78A
SAH  A7102 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER C7039
LEU C7042
PRO C6805
ALA C6997
ASP C6928
1.74A
None
None
None
None
SAH  C7102 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
LEU A7004
MET A6982
ASP A6942
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A7039
LEU A7042
PRO A6805
ALA A6997
ASP A6928
1.76A
None
None
None
None
SAH  A7102 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
PRO D  73
VAL D  72
ARG D  68
TYR D 123
GLY D  85
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
PRO B  73
VAL B  72
ARG B  68
TYR B 123
GLY B  85
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
SER D  51
PRO D 117
ALA D  90
ASP D  63
GLY D 129
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
PRO B  73
VAL B  72
ARG B  68
TYR B 123
GLY B  85
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
SER C  51
PRO C 117
ALA C  90
ASP C  63
GLY C 129
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
SER B  51
PRO B 117
ALA B  90
ASP B  63
GLY B 129
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
PRO D  73
VAL D  72
ARG D  68
TYR D 123
GLY D  85
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 9
PRO A6878
VAL B4295
VAL A6902
ILE B4352
GLY B4322
1.77A
SFG  A7103 ( 3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 10
PRO A6878
VAL B4295
VAL A6902
ILE B4352
GLY B4322
1.77A
SFG  A7103 ( 3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER A7041
LEU A7042
GLN A6885
ASP A6928
GLY A6879
1.73A24.48
None
None
None
SFG  A7103 ( 3.6A)
SFG  A7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		3 / 3
LEU A7004
MET A6982
ASP A6942
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 10
PRO C6878
VAL D4295
VAL C6902
ILE D4352
GLY D4322
1.76A
SFG  C7103 ( 3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER A7039
LEU A7042
PRO A6805
ALA A6997
ASP A6928
1.77A
None
None
None
None
SFG  A7103 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		3 / 3
LEU C7004
MET C6982
ASP C6942
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 9
PRO C6878
VAL D4295
VAL C6902
ILE D4352
GLY D4322
1.76A
SFG  C7103 ( 3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		3 / 3
LEU A6834
MET A6840
ASP A7044
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C7041
LEU C7042
GLN C6885
ASP C6928
GLY C6879
1.79A24.48
None
None
None
SFG  C7103 ( 3.7A)
SFG  C7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C7039
LEU C7042
PRO C6805
ALA C6997
ASP C6928
1.73A
FMT  C7111 ( 3.1A)
None
None
None
SFG  C7103 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A 201
PHE A 264
TYR A 279
ASP A 283
GLY A 239
1.65A23.06
EDO  A 405 (-4.1A)
None
EDO  A 405 (-4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
TYR B 180
TYR B 179
PRO B  68
PHE B 135
1.80A15.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B 201
PHE B 264
TYR B 279
ASP B 283
GLY B 239
1.64A23.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.52A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A  30
MET A  17
ASP A 187
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER B 139
PHE B 116
PRO B  98
ALA B  38
GLY B  79
1.78A
None
None
None
APR  B 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 140
CYH B 143
TYR B 113
PRO B 136
GLY A 103
1.79A23.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 140
CYH B 143
TYR B 113
PRO B 136
GLY A 103
1.79A23.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER A 139
PHE A 116
PRO A  98
ALA A  38
GLY A  79
1.77A
None
None
None
APR  A 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 140
CYH B 143
TYR B 113
PRO B 136
GLY A 103
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER C 139
PHE C 116
PRO C  98
ALA C  38
GLY C  79
1.77A
None
None
None
APR  C 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER D 139
PHE D 116
PRO D  98
ALA D  38
GLY D  79
1.78A
None
None
None
APR  D 201 (-3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER A 139
PHE A 116
PRO A  98
ALA A  38
GLY A  79
1.80A23.27
None
None
None
APR  A 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER C 139
PHE C 116
PRO C  98
ALA C  38
GLY C  79
1.79A23.27
None
None
None
APR  C 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
LEU A7004
MET A6982
ASP A6942
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
PRO A6878
VAL B4295
VAL A6902
ILE B4352
GLY B4322
1.79A
SAH  A7101 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 10
PRO A6878
VAL B4295
VAL A6902
ILE B4352
GLY B4322
1.78A
SAH  A7101 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 9
PRO D 116
VAL D 115
ARG D 111
VAL C  58
ILE C  68
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
PRO D 116
VAL D 115
ARG D 111
VAL C  58
ILE C  68
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.50A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A  30
MET A  17
ASP A 187
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
TYR A 296
GLU A 263
PRO A 248
PHE A 258
1.61A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
LEU A 125
PHE A 127
GLN A 121
ALA A 139
LEU A 117
1.55A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6y2f REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.51A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6y2f REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.48A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6y84 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.15A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.51A19.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU A  30
MET A  17
ASP A 187
1.52A19.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.15A19.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		3 / 3
LEU A  13
MET A  52
ASP A  67
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU C  40
LEU A  13
PHE B  92
GLN A  19
ASP A  67
1.76A14.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		3 / 3
LEU C  13
MET C  52
ASP C  67
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 10
PRO A  33
VAL A  32
ARG A  28
TYR A  83
GLY A  45
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 9
PRO A  33
VAL A  32
ARG A  28
TYR A  83
GLY A  45
1.43A
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER B 103
TYR C  31
TYR A 380
PRO A 412
1.67A35.88
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER H 103
TYR L  31
TYR E 380
PRO E 412
1.62A35.88
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR H  94
TYR H  95
PRO L  50
PHE H  64
1.36A35.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
TYR E 369
TYR H  52
TYR H  32
PHE E 377
1.79A21.51
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR B  94
TYR B  95
PRO C  50
PHE B  64
1.37A35.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
TYR E 396
SER E 359
GLU E 516
PRO E 521
1.42A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 10
TYR L 102
PRO H 105
VAL E 382
ILE H  34
GLY H  99
1.72A
None
None
DMS  L1601 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
TYR E 380
SER H 103
TYR L  98
PRO L 101
1.70A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 371
LEU A 368
PHE A 342
ALA A 435
ASP A 398
1.50A
DMS  A 901 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 10
TYR C 102
PRO B 105
VAL A 382
ILE B  34
GLY B  99
1.69A
None
None
DMS  A 905 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
TYR A 369
TYR B  52
TYR B  32
PHE A 377
1.79A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER E 371
LEU E 368
PHE E 342
ALA E 435
ASP E 398
1.47A
DMS  E 901 ( 4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER E 371
LEU E 368
PHE E 342
ALA E 435
ASP E 398
1.46A
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6ym0 HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER H 103
TYR L  31
TYR E 380
PRO E 412
1.72A36.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
TYR E 396
SER E 359
GLU E 516
PRO E 521
1.37A21.51
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR H  94
TYR H  95
PRO L  50
PHE H  64
1.37A36.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU A  30
MET A  17
ASP A 187
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.11A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.53A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 371
LEU A 368
PHE A 342
ALA A 435
ASP A 398
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
TYR A 396
SER A 359
GLU A 516
PRO A 521
1.42A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6yor IGG H CHAIN
IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 10
TYR C 102
PRO B 105
VAL A 382
ILE B  34
GLY B  99
1.72A
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6yor IGG H CHAIN
IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER B 103
TYR C  31
TYR A 380
PRO A 412
1.61A35.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
TYR E 369
TYR H  52
TYR H  32
PHE E 377
1.79A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
TYR E 396
SER E 359
GLU E 516
PRO E 521
1.42A21.08
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
TYR H  94
TYR H  95
PRO L  50
PHE H  64
1.35A35.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
TYR A 369
TYR B  52
TYR B  32
PHE A 377
1.79A21.08
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6yor IGG H CHAIN
IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER H 103
TYR L  31
TYR E 380
PRO E 412
1.62A35.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER E 371
LEU E 368
PHE E 342
ALA E 435
ASP E 398
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6yor IGG H CHAIN
IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
TYR E 380
SER H 103
TYR L  98
PRO L 101
1.71A21.08
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
TYR B  94
TYR B  95
PRO C  50
PHE B  64
1.36A35.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6yor IGG H CHAIN
IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 10
TYR L 102
PRO H 105
VAL E 382
ILE H  34
GLY H  99
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6yor IGG H CHAIN
IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
TYR A 380
SER B 103
TYR C  98
PRO C 101
1.71A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.57A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU A  30
MET A  17
ASP A 187
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER C 139
PHE C 116
PRO C  98
ALA C  38
GLY C  79
1.77A
None
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER E 139
PHE E 116
PRO E  98
ALA E  38
GLY E  79
1.78A
None
None
None
EPE  E 202 (-3.3A)
EPE  E 203 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER B 139
PHE B 116
PRO B  98
ALA B  38
GLY B  79
1.79A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER B 139
PHE B 116
PRO B  98
ALA B  38
GLY B  79
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER A 139
PHE A 116
PRO A  98
ALA A  38
GLY A  79
1.79A
None
None
None
EDO  A 202 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER E 139
PHE E 116
PRO E  98
ALA E  38
GLY E  79
1.80A21.02
None
None
None
EPE  E 202 (-3.3A)
EPE  E 203 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER D 139
PHE D 116
PRO D  98
ALA D  38
GLY D  79
1.79A
None
None
None
EDO  D 205 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER C 139
PHE C 116
PRO C  98
ALA C  38
GLY C  79
1.77A
None
None
None
MES  C 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER B 139
PHE B 116
PRO B  98
ALA B  38
GLY B  79
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER C 139
PHE C 116
PRO C  98
ALA C  38
GLY C  79
1.80A21.02
None
None
None
MES  C 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER A 139
PHE A 116
PRO A  98
ALA A  38
GLY A  79
1.78A
None
None
None
MES  A 201 (-3.5A)
EDO  A 204 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		3 / 3
LEU A  30
MET A  17
ASP A 187
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		7bqy MAIN PROTEASE

(SARS-CoV-2;
synthetic
construct)		5 / 12
PHE A 181
PRO A  52
ALA C   2
MET A 165
LEU C   4
1.52A22.94
None
None
02J  C   1 ( 3.6A)
None
PJE  C   5 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		7btf NSP12
(SARS-CoV-2)		6 / 10
TYR A 653
VAL A 535
ARG A 533
VAL A 353
PRO A 537
GLY A 345
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A 561
CYH A 563
PRO A 378
ALA A 660
GLY A 345
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		7btf NSP12
(SARS-CoV-2)		5 / 9
VAL A 535
ARG A 533
VAL A 353
PRO A 537
GLY A 345
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A 561
CYH A 563
PRO A 378
ALA A 660
GLY A 345
1.69A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 731
SER A 239
PHE A  45
TYR A 732
PRO A 243
1.70A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		7btf NSP12
(SARS-CoV-2)		4 / 7
TYR A  80
GLU A  84
PRO A 112
PHE A 219
1.50A7.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		7btf NSP7
NSP8
(SARS-CoV-2)		3 / 3
LEU D 117
MET D 129
ASP C  67
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 205
LEU A 245
PHE A 287
TYR A 237
ASP A 284
1.73A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		3 / 3
LEU A  30
MET A  17
ASP A 187
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.60A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 9
VAL A 535
ARG A 533
VAL A 353
PRO A 537
GLY A 345
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
SER C   4
CYH C   8
PHE A 843
TYR A 420
ASP A 845
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		7bv1 NSP12
(SARS-CoV-2)		6 / 10
TYR A 653
VAL A 535
ARG A 533
VAL A 353
PRO A 537
GLY A 345
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
SER C   4
CYH C   8
PHE A 843
TYR A 420
ALA A 423
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
SER C   4
CYH C   8
PHE A 843
TYR A 420
ASP A 845
1.58A15.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		3 / 3
LEU B  91
MET B  90
ASP A 523
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
SER C   4
CYH C   8
PHE A 843
TYR A 420
ASP A 845
1.62A15.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
LEU A 127
MET A 124
ASP A 135
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 9
VAL A 535
ARG A 533
VAL A 353
PRO A 537
GLY A 345
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
SER C   4
CYH C   8
PHE A 843
TYR A 420
ASP A 845
1.50A15.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
SER C   4
CYH C   8
PHE A 843
TYR A 420
ALA A 423
1.64A15.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
SER C   4
CYH C   8
PHE A 843
TYR A 420
ASP A 845
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
SER C   4
CYH C   8
PHE A 843
TYR A 420
ALA A 423
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		7bv2 NSP12
(SARS-CoV-2)		6 / 10
TYR A 653
VAL A 535
ARG A 533
VAL A 353
PRO A 537
GLY A 345
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 372
PHE A 368
PRO A 505
ALA B  86
GLY A 510
1.71A14.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
SER C   4
CYH C   8
PHE A 843
TYR A 420
ASP A 845
1.54A15.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		3 / 3
LEU B  91
MET B  90
ASP A 523
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
LEU A 907
MET A 906
ASP A 879
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 205
LEU A 245
PHE A 287
TYR A 237
ASP A 284
1.65A14.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 372
PHE A 368
PRO A 505
ALA B  86
GLY A 510
1.67A
None