Ligand ID: SAS


Drugbank ID:
DB00795
(Sulfasalazine)


Indication:
For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.

Get human targets for SAS in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'SAS' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
SER A 123
PHE A 140
TYR A 118
GLY B   2
LEU B   0
1.63A23.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.21A23.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU B  88
CYH B  73
PHE B  90
GLY A 100
LEU A  97
1.67A17.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B1262
CYH B1265
ALA B1206
GLY B1251
LEU B1250
1.69A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B1177
MET B1162
ASP B1153
1.15A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER C  19
LEU E  20
ALA C  26
GLY E  28
LEU E  27
1.67A13.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.22A23.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
LEU A 264
CYH A 263
ASP A 249
ASP D 352
MET D 348
1.52A22.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
LEU A 264
CYH A 263
ASP A 249
ASP D 352
MET D 348
1.51A22.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 10
PRO F 121
VAL F 120
ARG F 116
VAL B  63
GLY B  69
1.35A21.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		3 / 3
LEU C  18
MET C  57
ASP C  72
1.16A18.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 9
PRO F 121
VAL F 120
ARG F 116
VAL B  63
GLY B  69
1.35A21.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2ajf ACE2
(Homo
sapiens)		5 / 12
SER A 420
LEU A 418
PHE A 369
GLN A 300
ASP A 368
1.66A21.22
NAG  A1546 (-3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2ajf ACE2
(Homo
sapiens)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.37A21.22
 CL  A 902 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		2ajf ACE2
(Homo
sapiens)		5 / 12
SER A 420
LEU A 418
PHE A 369
GLN A 300
ASP A 368
1.68A21.22
NAG  A1546 (-3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2ajf ACE2
(Homo
sapiens)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.37A21.22
 CL  A 902 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.52A23.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.56A23.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH B 128
PHE B 112
TYR B 126
ASP B 176
GLY B 174
1.49A24.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH B 128
PHE B 112
TYR B 126
ASP B 176
GLY B 174
1.52A24.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.14A24.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2amq 3C-LIKE
PROTEINASE

(SARSr-CoV;
synthetic
construct)		5 / 12
PHE B 181
PRO B  52
ALA D   2
MET B 165
LEU D   4
1.48A24.57
None
None
02J  D   1 ( 3.6A)
None
PJE  D   5 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER C 919
LEU A 920
ALA C 926
GLY A 928
LEU A 927
1.67A9.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2bx4 3C-LIKE PROTEINASE
(SARS-COV
Sin2774)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.44A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2bx4 3C-LIKE PROTEINASE
(SARS-COV
Sin2774)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.40A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
LEU D 353
PHE D 287
PRO D 303
ALA C 312
GLY D 296
1.37A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
LEU D 353
PHE D 287
PRO D 303
ALA C 312
GLY D 296
1.34A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		4 / 7
SER H 179
TYR L 179
PRO H 167
PHE L 119
1.50A22.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 10
PHE C 133
VAL C  50
ILE B 132
PRO C 137
GLY C 131
1.68A25.11
None
None
APR  B 477 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 9
PHE C 133
VAL C  50
ILE B 132
PRO C 137
GLY C 131
1.68A25.11
None
None
APR  B 477 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU C 260
CYH C 261
GLN C 122
GLY C 101
LEU C 102
1.59A22.48
 BR  C 317 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
LEU N  45
MET I  63
ASP M  64
1.27A17.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
TYR C 383
TYR C 410
GLU C 502
PRO C 413
1.74A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU A 499
PHE A 501
TYR A 367
ALA A 371
LEU A 374
1.69A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
LEU B 353
PHE B 287
PRO B 303
ALA A 312
GLY B 296
1.48A12.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
SER A 319
PHE B 287
ASP B 289
ASP B 291
GLY B 296
1.61A12.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2gri NSP3
(SARSr)		3 / 3
LEU A  90
MET A 103
ASP A  29
0.77A18.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
SER A 144
TYR A 118
GLU A 166
PHE A 140
1.66A16.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.50A23.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		2idy NSP3
(SARSr-CoV)		4 / 7
TYR A  19
GLU A  46
PRO A   2
PHE A  99
1.18A22.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
SER B 319
PHE A 287
ASP A 289
ASP A 291
GLY A 296
1.62A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		5 / 9
PRO A  74
VAL A  73
ILE A  -3
TYR A 124
GLY A  86
1.54A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		5 / 10
PRO A  74
VAL A  73
ILE A  -3
TYR A 124
GLY A  86
1.54A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.14A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.47A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.50A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2q6g POLYPEPTIDE CHAIN
REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
PHE B 181
PRO B  52
ALA D   3
MET B 165
LEU D   5
1.57A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.17A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.49A23.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.52A23.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.41A23.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
SER E 261
LEU E 263
PHE E 240
ASP E 239
GLY E 243
1.65A24.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 10
TYR A 278
PHE A 268
PRO A 270
VAL B  10
ILE A 295
1.70A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.18A23.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		2wct NSP3
(SARSr-CoV)		5 / 12
CYH D 456
PHE D 436
GLN D 426
ASP D 433
MET D 434
1.79A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		2xyq NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 10
PRO A  80
VAL B  42
VAL A 104
ILE B  99
GLY B  69
1.75A21.16
SAH  A1293 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		3 / 3
LEU A 206
MET A 184
ASP A 144
1.12A23.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		2xyq NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 9
PRO A  80
VAL B  42
VAL A 104
ILE B  99
GLY B  69
1.75A21.16
SAH  A1293 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		2xyr NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 10
PRO A  80
VAL B  42
VAL A 104
ILE B  99
GLY B  69
1.75A21.16
SFG  A1298 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		2xyr NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 9
PRO A  80
VAL B  42
VAL A 104
ILE B  99
GLY B  69
1.75A21.16
SFG  A1298 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		3 / 3
LEU A 206
MET A 184
ASP A 144
1.09A23.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
SER L  34
LEU L  36
PHE L  98
TRP L  96
TYR L  91
1.76A22.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
LEU B 100
TYR B  32
ALA B  24
GLY B 104
LEU B   4
1.62A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
LEU B 176
MET B 123
ASP B 269
1.28A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.42A21.35
 CL  A 902 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		3d0g ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
TYR A  34
TYR E 484
TYR E 481
PRO E 493
1.67A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.41A21.35
 CL  A 902 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A 456
SER A 507
LEU A 176
ASP A 494
MET A 474
1.80A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER E 358
LEU E 355
PHE E 329
ALA E 422
ASP E 385
1.43A16.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3d0i SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER E 358
LEU E 355
PHE E 329
ALA E 422
ASP E 385
1.51A18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		3d0i SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
SER E 500
TYR E 383
GLU E 502
PHE E 416
1.33A22.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.49A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.08A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.52A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		3e9s NSP3
(SARSr-CoV)		5 / 12
LEU A 260
CYH A 261
GLN A 122
GLY A 101
LEU A 102
1.63A23.21
 CL  A 320 (-4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH B 128
PHE B 112
TYR B 126
ASP B 176
GLY B 174
1.46A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH B 128
PHE B 112
TYR B 126
ASP B 176
GLY B 174
1.50A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.37A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.56A23.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
SER A  35
LEU A   4
ALA B 107
MET A 101
GLY B 100
1.33A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
SER A  35
LEU A   4
ALA B 107
MET A 101
GLY B 100
1.27A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.19A24.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3i6g HLA, A-2
(Homo
sapiens)		3 / 3
LEU A 272
MET A 189
ASP A 183
1.19A19.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH B 128
PHE B 112
TYR B 126
ASP B 176
GLY B 174
1.47A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.33A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH B 128
PHE B 112
TYR B 126
ASP B 176
GLY B 174
1.50A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		3r24 NSP10 AND NSP11
(SARSr-CoV)		5 / 10
PRO B 107
VAL B 108
VAL B  97
ILE B  81
TYR B  76
1.78A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		3r24 NSP10 AND NSP11
(SARSr-CoV)		5 / 9
PRO B 107
VAL B 108
VAL B  97
ILE B  81
TYR B  76
1.78A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		5 / 9
PRO A  80
VAL B  42
VAL A 104
ILE B  99
GLY B  69
1.72A21.56
SAM  A 302 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		5 / 10
PRO A  80
VAL B  42
VAL A 104
ILE B  99
GLY B  69
1.72A21.56
SAM  A 302 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		3 / 3
LEU A 206
MET A 184
ASP A 144
1.15A25.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
SER F 336
TYR F 438
TYR F 440
PHE F 387
1.69A22.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.41A21.48
 CL  A 902 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.40A21.48
 CL  A 902 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
LEU B 176
MET B 123
ASP B 269
1.31A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
TYR A 385
GLU A 564
PRO A 389
PHE A 400
1.76A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.55A23.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.52A23.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3v3m 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU A 177
MET A 162
ASP A 153
1.11A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		3vb6 3C-LIKE PROTEINASE
C6Z INHIBITOR
(SARSr-CoV)		5 / 12
PHE A 181
PRO A  52
ALA E   4
MET A 165
LEU E   6
1.47A23.87
None
None
None
None
0JU  E   7 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.48A23.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.15A23.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.45A23.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A 260
CYH A 261
GLN A 122
GLY A 101
LEU A 102
1.61A23.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.51A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.55A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 12
LEU A 260
CYH A 261
GLN A 122
GLY A 101
LEU A 102
1.54A23.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.00A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		4wy3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.48A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		4wy3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.51A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.48A24.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 177
MET B 162
ASP B 153
1.12A24.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
CYH A 128
PHE A 112
TYR A 126
ASP A 176
GLY A 174
1.46A24.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
SER D 407
LEU D 406
TYR D 420
PRO D 412
GLY D 416
1.63A20.83
None
None
G3A  D 606 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
LEU D 495
SER D 470
CYH D 473
TYR D 491
MET D 315
1.79A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
SER D 407
LEU D 406
TYR D 420
PRO D 412
GLY D 416
1.65A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
TYR D 138
TYR D  72
GLU A 135
PRO A 131
1.79A16.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU D 260
CYH D 261
GLN D 122
GLY D 101
LEU D 102
1.59A23.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
SER M  15
LEU M  14
PHE A   8
PRO M   8
ASP A  10
1.64A17.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU B 260
CYH B 261
GLN B 122
GLY B 101
LEU B 102
1.56A23.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
PHE C 700
PRO C1051
VAL C1050
VAL C 893
ILE C 704
1.55A10.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
PHE C 700
PRO C1051
VAL C1050
VAL C 893
ILE C 704
1.55A10.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
SER B1151
LEU B 780
TYR B1153
GLN B 772
GLY C 953
1.66A12.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
LEU B 673
PRO B 658
ALA B 678
MET C 906
GLY C 904
1.50A12.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
LEU B 673
PRO B 658
ALA B 678
MET C 906
GLY C 904
1.47A12.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
PHE C  47
PRO B 547
GLN B 550
ASP B 560
ASP B 572
1.34A12.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
PHE C  47
PRO B 547
GLN B 550
ASP B 560
ASP B 572
1.31A12.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		5x5f S PROTEIN
(MERS-CoV)		3 / 3
LEU A 938
MET A 939
ASP C 664
1.27A12.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		5x5f S PROTEIN
(MERS-CoV)		4 / 7
SER B1151
TYR B1153
TYR B1171
PHE C 967
1.69A6.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER A 949
LEU A 948
PHE B 558
GLN A 818
ASP B 572
1.61A12.97
SER  A 949 ( 0.0A)
LEU  A 948 ( 0.6A)
PHE  B 558 ( 1.3A)
GLN  A 818 ( 0.6A)
ASP  B 572 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
TYR C 383
SER C 346
GLU C 502
PRO C 507
1.58A7.57
TYR  C 383 ( 1.3A)
SER  C 346 ( 0.0A)
GLU  C 502 ( 0.6A)
PRO  C 507 ( 1.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A 260
CYH A 261
GLN A 122
GLY A 101
LEU A 102
1.54A23.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		4 / 7
TYR a  36
SER a  35
GLU a  33
PHE A 909
1.79A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU C 983
LEU C 736
TYR C 738
GLN C 744
ASP C 719
1.66A12.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6acj ACE2
(Homo
sapiens)		5 / 12
LEU D  79
LEU D  73
PHE D  32
GLN D 101
ASP D  30
1.58A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6acj ACE2
(Homo
sapiens)		3 / 3
LEU D 176
MET D 123
ASP D 269
1.22A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
TYR C 383
SER C 346
GLU C 502
PRO C 507
1.37A7.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER A 358
LEU A 355
PHE A 329
ALA A 422
ASP A 385
1.43A12.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
PHE A 700
PRO A1051
VAL A1050
VAL A 893
ILE A 704
1.72A10.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU A 216
SER A  35
PRO A 210
GLN A 201
ASP A 274
1.72A12.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
PHE A 700
PRO A1051
VAL A1050
VAL A 893
ILE A 704
1.72A10.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
SER B 500
TYR B 410
TYR B 383
GLU B 502
1.55A6.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
PHE B 700
PRO B1051
VAL B1050
VAL B 893
ILE B 704
1.70A9.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER B 957
LEU B 948
PHE A 558
ASP A 560
ASP A 554
1.58A13.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
PHE B 700
PRO B1051
VAL B1050
VAL B 893
ILE B 704
1.70A9.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER B 957
LEU B 948
PHE A 558
ASP A 560
ASP A 554
1.57A13.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
LEU A  52
MET A 263
ASP A 296
1.23A13.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6cs2 ACE2
(Homo
sapiens)		5 / 12
SER D 502
LEU D 503
PHE D 452
ALA D 264
GLY D 268
1.45A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
LEU A 168
MET A   5
ASP A 177
1.16A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6jyt HELICASE
(SARSr-CoV)		5 / 12
LEU A 384
PHE A 373
TYR A 396
ASP A 374
GLY A 400
1.63A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6jyt HELICASE
(SARSr-CoV)		5 / 12
SER A  13
LEU A  92
MET A  68
GLY A  67
LEU A  65
1.56A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6jyt HELICASE
(SARSr-CoV)		4 / 7
SER A 555
TYR A 515
GLU A 551
PHE A 546
1.70A11.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6m0j ACE2
(Homo
sapiens)		4 / 7
TYR A 385
GLU A 564
PRO A 389
PHE A 400
1.73A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6m0j ACE2
(Homo
sapiens)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.43A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6m0j ACE2
(Homo
sapiens)		5 / 12
SER A 502
LEU A 503
PHE A 452
ALA A 264
GLY A 268
1.42A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 7
TYR A 139
SER A 143
PRO A 147
PHE A 421
1.57A12.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6m17 ACE2
(Homo
sapiens)		3 / 3
LEU D 558
MET D 557
ASP D 543
1.15A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6m17 ACE2
(Homo
sapiens)		5 / 12
SER D 502
LEU D 503
PHE D 452
ALA D 264
GLY D 268
1.49A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6m17 ACE2
(Homo
sapiens)		5 / 12
SER D 502
LEU D 503
PHE D 452
ALA D 264
GLY D 268
1.48A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LEU A  61
CYH A  62
PHE A  70
TYR A 322
GLY A 311
1.54A16.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LEU A  61
CYH A  62
PHE A  70
TYR A 322
GLY A 311
1.55A16.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6m1d ACE2
(Homo
sapiens)		4 / 7
SER B 611
GLU B 489
PRO B 263
PHE B 684
1.20A8.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 10
PRO C 442
VAL C 441
VAL C 103
ILE C 216
GLY C 285
1.43A16.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 9
PRO C 442
VAL C 441
VAL C 103
ILE C 216
GLY C 285
1.43A16.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
SER A 500
TYR A 383
GLU A 502
PHE A 416
1.75A6.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6nur NSP12
NSP8
(SARSr-CoV)		3 / 3
LEU B  91
MET B  90
ASP A 523
1.37A23.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6nur NSP12
(SARSr-CoV)		5 / 12
LEU A 205
LEU A 245
PHE A 287
TYR A 237
ASP A 284
1.66A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		6nus NSP12
(SARSr-CoV)		5 / 9
VAL A 535
ARG A 533
VAL A 353
PRO A 537
GLY A 345
1.38A12.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		6nus NSP12
(SARSr-CoV)		6 / 10
TYR A 653
VAL A 535
ARG A 533
VAL A 353
PRO A 537
GLY A 345
1.53A12.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
TYR E 396
SER E 359
GLU E 516
PRO E 521
1.52A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER F 371
LEU F 368
PHE F 342
ALA F 435
ASP F 398
1.50A20.98
None
None
NAG  F 601 (-4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6vw1 ACE2
(Homo
sapiens)		3 / 3
LEU A 176
MET A 123
ASP A 269
1.21A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6vw1 ACE2
(Homo
sapiens)		4 / 7
TYR B 385
GLU B 564
PRO B 389
PHE B 400
1.78A11.68
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
TYR L  92
SER H  99
TYR L  91
PRO H 100
1.76A37.20
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
TYR H  90
TYR H  91
PRO L  44
PHE H  63
1.37A35.61
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR H  94
TYR H  95
PRO L  50
PHE H  64
1.36A35.88
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR B  94
TYR B  95
PRO C  50
PHE B  64
1.37A35.88
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
TYR H  94
TYR H  95
PRO L  50
PHE H  64
1.37A36.15
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
TYR H  94
TYR H  95
PRO L  50
PHE H  64
1.35A35.88
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
TYR B  94
TYR B  95
PRO C  50
PHE B  64
1.36A35.88
None