Ligand ID: REM


Drugbank ID:
DB00212
(Remikiren)


Indication:
For the treatment of hypertension and heart failure

Get human targets for REM in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'REM'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		5 / 12
ASP A 116
THR A  10
LEU A  81
ALA A 117
HIS B  31
1.49A19.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 12
GLY A  11
SER A  45
THR A  46
VAL A  14
SER A  29
1.74A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN B1306
GLY B1302
LEU A 141
SER A 121
SER A 147
1.49A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		4 / 5
TYR G  17
ALA G  50
ALA G  58
TYR E  76
1.64A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		2dd8 IGG LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLN S 401
ASP S 392
GLY S 490
SER L  94
SER S 362
1.68A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
ASP H 144
SER L 181
THR L 132
SER H 179
SER L 178
1.56A23.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		2dd8 IGG HEAVY CHAIN
(Homo
sapiens)		4 / 5
TYR H  91
ALA H   9
ALA H  88
MET H  48
1.50A23.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLY A 215
SER A   1
LEU A 282
SER B 139
HIS B 172
1.48A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLY A 283
THR B 169
LEU A 282
SER B 139
HIS B 172
1.56A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
ALA B 120
ALA B 279
TYR B 284
MET B 294
1.61A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		4 / 5
TYR D 102
ALA D  61
ALA D  97
TYR D  95
1.39A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		2kqv NSP3
(SARSr-CoV)		4 / 5
TYR A  88
ALA A  33
TYR A  61
MET A 102
1.40A19.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
GLN A 256
GLY B 170
SER B 139
ALA A   0
SER B 144
1.59A22.92
None
None
None
None
WR1  B 602 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 5
TYR D  88
ALA D  54
ALA D  94
MET D 271
1.73A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 124
PHE A 291
LEU A 115
SER A 147
HIS A 163
1.56A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 5
TYR D   7
ALA D  59
TYR D  32
MET B 104
1.54A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		2w2g NSP3
(SARSr-CoV)		4 / 5
TYR B 487
ALA B 503
TYR B 483
MET B 428
1.73A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		2xyr NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
GLN B  65
GLY B  94
SER B  72
SER B  67
ALA A  83
1.59A15.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		2xyv NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
GLN B  65
GLY B  94
SER B  72
SER B  67
ALA A  83
1.59A15.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
SER L 116
THR L 114
LEU H 140
SER H 182
HIS H 166
1.57A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
SER L 116
THR L 114
LEU H 140
SER H 182
HIS H 166
1.60A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
GLN A  86
ASP A 216
GLY A 214
VAL A 209
ASP A 213
1.73A20.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		3e9s NSP3
(SARSr-CoV)		4 / 5
ALA A 120
ALA A 279
TYR A 284
MET A 294
1.70A22.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B  13
ALA B 116
SER B 144
SER B 139
HIS B 172
1.61A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 299
GLY A 283
PHE A 291
SER B 139
HIS B 172
1.35A22.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		3i6g HLA, A-2
(Homo
sapiens)		4 / 5
TYR A 159
ALA A 153
ALA D 158
TYR D 159
1.64A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		3i6k HLA, A-2
(Homo
sapiens)		5 / 12
GLY E 112
PHE E   8
LEU E 110
ASP E 102
SER E   2
1.60A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		5 / 12
GLN B  65
GLY B  94
SER B  72
SER B  67
ALA A  83
1.61A16.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 5
ALA A 120
ALA A 279
TYR A 284
MET A 294
1.62A23.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		4 / 5
ALA A 120
ALA A 279
TYR A 284
MET A 294
1.51A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A  69
GLY A 146
SER A 121
SER A 123
ALA A 116
1.61A22.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
GLY B 123
SER B  56
LEU B 105
SER B  12
ALA B  96
1.29A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_2
(RENIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 4
VAL B 199
TYR B 124
PRO B 106
PHE B 198
1.61A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_2
(RENIN)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 4
VAL B 199
TYR B 124
PRO B 106
PHE B 198
1.63A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
GLY D 123
SER D  56
LEU D 105
SER D  12
ALA D  96
1.37A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
ALA D 120
ALA D 279
TYR D 284
MET D 294
1.61A21.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
GLN B 168
GLY B  88
VAL B 115
SER B 171
SER B 178
1.71A20.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 5
TYR C 235
ALA P  20
TYR C  69
MET C  72
1.61A20.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_2
(RENIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 4
VAL C 199
TYR C 124
PRO C 106
PHE C 198
1.53A20.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
GLY C 123
SER C  56
LEU C 105
SER C  12
ALA C  96
1.30A20.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
ALA B 120
ALA B 279
TYR B 284
MET B 294
1.57A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
GLY A 175
THR A 209
ASP A 174
ALA A 223
SER A 227
1.61A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLN C 835
ASP B 554
ASP B 560
SER B 574
SER B 541
1.58A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLN C 835
ASP B 554
ASP B 560
SER B 574
SER B 541
1.56A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
GLY A 959
PHE A 865
LEU A 964
SER A 858
SER A 855
1.49A13.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
GLN B1056
VAL A 575
LEU A 415
ALA A 434
SER A 435
1.48A13.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN C 835
GLY A 534
PHE A 578
LEU A 532
SER A 574
1.52A15.18
GLN  C 835 ( 0.6A)
GLY  A 534 ( 0.0A)
PHE  A 578 ( 1.3A)
LEU  A 532 ( 0.5A)
SER  A 574 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 5
ALA A 120
ALA A 279
TYR A 284
MET A 294
1.55A22.37
 NA  A 404 ( 3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6acg ACE2
(Homo
sapiens)		5 / 12
GLN D 522
THR D 449
VAL D 581
LEU D 595
ALA D 443
1.71A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN B 992
GLY B 751
THR B 716
ALA B 997
SER B 712
1.44A15.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6ack ACE2
(Homo
sapiens)		5 / 12
PHE D 369
LEU D 529
SER D 317
SER D 547
ALA D 550
1.54A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6ack ACE2
(Homo
sapiens)		4 / 5
TYR D 521
ALA D 396
TYR D 385
MET D 557
1.24A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLN A 835
ASP C 554
ASP C 560
SER C 574
SER C 541
1.65A14.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLN A 835
ASP C 554
ASP C 560
SER C 574
SER C 541
1.60A14.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY C 552
SER A  49
THR A  51
ASP C 560
SER C 556
1.38A14.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY C 552
SER A  49
THR A  51
ASP C 560
SER C 556
1.31A14.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6cs2 ACE2
(Homo
sapiens)		4 / 5
TYR D 521
ALA D 396
TYR D 385
MET D 557
1.30A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6cs2 ACE2
(Homo
sapiens)		5 / 12
SER D 411
LEU D 554
SER D 317
SER D 547
ALA D 550
1.61A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6jyt HELICASE
(SARSr-CoV)		5 / 12
SER B  38
VAL B  60
ALA B  18
SER A  38
HIS A  39
1.62A21.59
None
None
ZN  B 703 (-2.4A)
None
ZN  A 703 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6jyt HELICASE
(SARSr-CoV)		5 / 12
GLN A 281
SER A 289
THR A 286
ASP A 374
ALA A 313
1.56A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
GLN F 949
GLY E 946
THR D 941
ALA F 944
SER F 940
1.55A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
SER F 937
THR F 941
LEU E1193
SER E 940
ALA E1190
1.35A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6m0j SPIKE RECEPTOR
BINDING DOMAIN
(SARS-CoV-2)		4 / 5
TYR E 423
ALA E 348
ALA E 435
TYR E 508
1.69A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
GLY A 478
SER A 184
THR A 185
LEU A 475
SER A 188
1.67A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
GLY C 478
SER C 184
THR C 185
LEU C 475
SER C 188
1.59A20.16
None
NAG  C 702 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 5
TYR A 488
ALA A 273
TYR A 129
MET A 124
1.80A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6m1d ACE2
(Homo
sapiens)		4 / 5
TYR B 641
ALA D 687
ALA D 650
TYR D 654
1.71A17.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6m1d ACE2
(Homo
sapiens)		5 / 12
GLY B 486
SER B 607
LEU B 262
SER B 611
SER B 257
1.63A17.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 143
SER A 121
SER A 123
ALA A 116
1.69A22.86
None
3WL  A 401 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 146
SER A 121
SER A 123
ALA A 116
1.56A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6m71 NSP12
(SARS-CoV-2)		4 / 5
TYR A 619
ALA A 690
ALA A 625
TYR A 456
1.07A17.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY B 655
THR B 644
SER B 659
HIS B 661
ALA B 658
1.60A14.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN A 632
GLY A 579
SER A 582
VAL A 601
SER C 750
1.73A14.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L 136
THR L 185
VAL H 183
ASP H 158
SER L 132
1.59A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6nur NSP12
(SARSr-CoV)		4 / 5
TYR A 619
ALA A 690
ALA A 625
TYR A 456
1.20A17.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_2
(RENIN)		6nur NSP12
NSP8
(SARSr-CoV)		4 / 4
VAL A 675
TYR A 346
PRO B 116
PHE A 396
1.72A17.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6nus NSP12
(SARSr-CoV)		5 / 12
GLN A 573
GLY A 683
SER A 564
THR A 567
ASP A 684
1.73A17.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN C1005
GLY B 971
THR B 998
PHE C 759
ASP C 994
1.44A14.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 404
SER C 438
VAL C 350
ALA C 435
SER C 375
1.44A14.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6vw1 ACE2
(Homo
sapiens)		4 / 5
TYR B 385
ALA B 403
ALA B 348
MET B 323
1.62A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY B  97
LEU B 127
ALA B 134
SER B 139
HIS B 138
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN B 414
ASP B 405
SER C 375
THR C 376
SER C 371
1.59A14.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY B 404
SER B 438
VAL B 350
ALA B 435
SER B 375
1.74A14.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN A1005
GLY C 971
THR C 998
PHE A 759
ASP A 994
1.52A14.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN A1036
GLY B 889
THR A1066
ASP A1041
HIS A1064
1.54A14.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6w37 PROTEIN 7A
(SARS-CoV-2)		5 / 12
GLY A  11
SER A  45
THR A  46
VAL A  14
SER A  29
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
SER L 131
THR L 180
VAL H 169
LEU H 124
SER L 121
1.79A19.71
None
None
GOL  L 301 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
SER H 130
THR H 131
LEU H 138
SER L 114
ALA H 137
1.73A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
SER L 131
THR L 180
LEU H 124
SER L 177
SER H 179
1.77A19.71
None
None
None
None
GOL  L 301 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 5
TYR C 423
ALA C 348
ALA C 435
TYR C 508
1.74A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
GLY C 404
SER C 438
VAL C 350
ALA C 435
SER C 375
1.71A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 5
TYR L  87
ALA H  93
ALA L  34
TYR L  49
1.48A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
GLY H 139
SER L 176
VAL H 163
LEU H 141
SER H 177
1.68A21.41
None
GOL  L 301 (-3.1A)
None
None
GOL  L 301 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
SER L 131
THR L 180
VAL H 169
ASP H 144
SER L 127
1.43A19.71
None
None
GOL  L 301 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLN B4318
GLY B4347
SER B4325
SER B4320
ALA A6881
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLN B4318
GLY B4347
SER B4325
SER B4320
ALA A6881
1.62A17.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLN D4318
GLY D4347
SER D4325
SER D4320
ALA C6881
1.61A17.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
TYR A 171
ALA A 116
ALA A 153
TYR A  83
1.60A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
TYR A 251
ALA A 246
ALA A 261
TYR A 273
1.79A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
TYR B 171
ALA B 116
ALA B 153
TYR B  83
1.43A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
TYR C  95
ALA C 116
ALA C 107
TYR B 268
1.44A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
TYR A  95
ALA A 116
ALA A 107
TYR C 268
1.35A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
ALA C 145
ALA C 114
TYR C 112
MET C 169
1.76A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
ALA A 145
ALA A 114
TYR A 112
MET A 169
1.63A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
TYR C 171
ALA C 116
ALA C 153
TYR C  83
1.65A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
TYR B  95
ALA B 116
ALA B 107
TYR A 268
1.40A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
ALA B 145
ALA B 114
TYR B 112
MET B 169
1.68A21.92
None
CL  B 502 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLN D4318
GLY D4347
SER D4325
SER D4320
ALA C6881
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLN B4318
GLY B4347
SER B4325
SER B4320
ALA A6881
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLN D4318
GLY D4347
SER D4325
SER D4320
ALA C6881
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLN B4318
GLY B4347
SER B4325
SER B4320
ALA A6881
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 146
SER A 121
SER A 123
ALA A 116
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 143
SER A 121
SER A 123
ALA A 116
1.67A
None
U5G  A 401 (-3.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLN B4318
GLY B4347
SER B4325
SER B4320
ALA A6881
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 5
TYR A 171
ALA A 116
ALA A 153
TYR A  83
1.64A21.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 5
ALA A 145
ALA A 114
TYR A 112
MET A 169
1.67A21.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6y84 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 146
SER A 121
SER A 123
ALA A 116
1.43A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		6 / 12
SER L 137
THR L 186
VAL L 156
LEU H 128
SER L 183
SER H 183
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
TYR C  93
ALA B  97
ALA C  40
TYR C  55
1.50A20.71
None
None
None
DMS  A 905 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLY B 143
SER C 182
VAL B 167
LEU B 145
SER B 181
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		6 / 12
SER C 137
THR C 186
VAL C 156
LEU B 128
SER C 183
SER B 183
1.69A
None
None
MLI  C 305 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
TYR L  93
ALA H  97
ALA L  40
TYR L  55
1.52A20.71
None
None
None
DMS  L1601 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLY H 143
SER L 182
VAL H 167
LEU H 145
SER H 181
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L 137
THR L 135
LEU H 128
SER H 124
SER L 127
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER C 137
THR C 135
LEU B 128
SER B 124
SER C 127
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY E 404
SER E 438
VAL E 350
ALA E 435
SER E 375
1.73A
DMS  E 902 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L 137
THR L 135
LEU H 128
SER H 124
SER L 127
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER C 137
THR C 186
LEU B 128
SER C 183
SER B 183
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY A 404
SER A 438
VAL A 350
ALA A 435
SER A 375
1.74A
DMS  A 903 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L 137
THR L 186
VAL H 173
ASP H 148
SER L 133
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TYR A 423
ALA A 348
ALA A 435
TYR A 508
1.63A21.49
None
None
None
DMS  A 903 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER C 137
THR C 186
VAL B 173
ASP B 148
SER C 133
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TYR E 423
ALA E 348
ALA E 435
TYR E 508
1.66A21.49
None
DMS  E 905 ( 4.0A)
None
DMS  E 902 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L 137
THR L 186
VAL H 173
ASP H 148
SER L 133
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TYR E 423
ALA E 348
ALA E 435
TYR E 508
1.62A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L 137
THR L 135
LEU H 128
SER H 124
SER L 127
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		6 / 12
SER L 137
THR L 186
VAL L 156
LEU H 128
SER L 183
SER H 183
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY E 404
SER E 438
VAL E 350
ALA E 435
SER E 375
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 5
TYR L  93
ALA H  97
ALA L  40
TYR L  55
1.55A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 146
SER A 121
SER A 123
ALA A 116
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 143
SER A 121
SER A 123
ALA A 116
1.63A
None
P6N  A 502 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 5
TYR L  93
ALA H  97
ALA L  40
TYR L  55
1.51A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY A 404
SER A 438
VAL A 350
ALA A 435
SER A 375
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L 137
THR L 186
VAL H 173
ASP H 148
SER L 133
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 5
TYR C  93
ALA B  97
ALA C  40
TYR C  55
1.51A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		6 / 12
SER C 137
THR C 186
VAL C 156
LEU B 128
SER C 183
SER B 183
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L 137
THR L 135
LEU H 128
SER H 124
SER L 127
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C 137
THR C 186
VAL B 173
ASP B 148
SER C 133
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
GLY H 143
SER L 182
VAL H 167
LEU H 145
SER H 181
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY E 404
SER E 438
VAL E 350
ALA E 435
SER E 375
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L 137
THR L 135
LEU H 128
SER H 124
SER L 127
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		6 / 12
SER L 137
THR L 186
VAL L 156
LEU H 128
SER L 183
SER H 183
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C 137
THR C 135
LEU B 128
SER B 124
SER C 127
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TYR A 423
ALA A 348
ALA A 435
TYR A 508
1.66A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
GLY B 143
SER C 182
VAL B 167
LEU B 145
SER B 181
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C 137
THR C 135
LEU B 128
SER B 124
SER C 127
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TYR E 423
ALA E 348
ALA E 435
TYR E 508
1.66A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 143
SER A 121
SER A 123
ALA A 116
1.67A
None
PK8  A 401 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 146
SER A 121
SER A 123
ALA A 116
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY E  97
LEU E 127
ALA E 134
SER E 139
HIS E 138
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  78
SER C 128
VAL C  36
LEU C 108
HIS C 138
1.59A
None
MES  C 201 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		7btf NSP12
(SARS-CoV-2)		4 / 5
TYR A 619
ALA A 690
ALA A 625
TYR A 456
1.10A17.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 143
SER A 121
SER A 123
ALA A 116
1.67A
None
JRY  A 401 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 146
SER A 121
SER A 123
ALA A 116
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
TYR A 619
ALA A 690
ALA A 625
TYR A 456
1.12A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 698
SER A 635
VAL A 476
LEU A 576
ALA A 690
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 573
GLY A 683
SER A 564
THR A 567
ASP A 684
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 698
PHE A 694
ASP A 618
SER A 795
ALA A 797
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 573
GLY A 683
SER A 564
THR A 567
ASP A 684
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLN A 573
GLY A 683
SER A 564
THR A 567
ASP A 684
1.77A
None
U  T  10 ( 3.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
TYR A 619
ALA A 690
ALA A 625
TYR A 456
1.14A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLN A 698
SER A 635
VAL A 476
LEU A 576
ALA A 690
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLN A 573
GLY A 683
SER A 564
THR A 567
ASP A 684
1.72A
None
U  T  10 ( 3.1A)
None
None
None