Ligand ID: REM


Drugbank ID:
DB00212
(Remikiren)


Indication:
For the treatment of hypertension and heart failure

Get human targets for REM in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'REM' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
GLN F 949
GLY E 946
THR D 941
ALA F 944
SER F 940
1.55A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
SER F 937
THR F 941
LEU E1193
SER E 940
ALA E1190
1.35A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6m0j SPIKE RECEPTOR
BINDING DOMAIN
(SARS-CoV-2)		4 / 5
TYR E 423
ALA E 348
ALA E 435
TYR E 508
1.69A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 143
SER A 121
SER A 123
ALA A 116
1.69A22.86
None
3WL  A 401 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 146
SER A 121
SER A 123
ALA A 116
1.56A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6m71 NSP12
(SARS-CoV-2)		4 / 5
TYR A 619
ALA A 690
ALA A 625
TYR A 456
1.07A17.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN C1005
GLY B 971
THR B 998
PHE C 759
ASP C 994
1.44A14.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 404
SER C 438
VAL C 350
ALA C 435
SER C 375
1.44A14.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY B  97
LEU B 127
ALA B 134
SER B 139
HIS B 138
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN B 414
ASP B 405
SER C 375
THR C 376
SER C 371
1.59A14.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY B 404
SER B 438
VAL B 350
ALA B 435
SER B 375
1.74A14.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN A1005
GLY C 971
THR C 998
PHE A 759
ASP A 994
1.52A14.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN A1036
GLY B 889
THR A1066
ASP A1041
HIS A1064
1.54A14.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6w37 PROTEIN 7A
(SARS-CoV-2)		5 / 12
GLY A  11
SER A  45
THR A  46
VAL A  14
SER A  29
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 5
TYR C 423
ALA C 348
ALA C 435
TYR C 508
1.74A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
GLY C 404
SER C 438
VAL C 350
ALA C 435
SER C 375
1.71A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLN B4318
GLY B4347
SER B4325
SER B4320
ALA A6881
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLN B4318
GLY B4347
SER B4325
SER B4320
ALA A6881
1.62A17.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLN D4318
GLY D4347
SER D4325
SER D4320
ALA C6881
1.61A17.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
TYR A 171
ALA A 116
ALA A 153
TYR A  83
1.60A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
TYR A 251
ALA A 246
ALA A 261
TYR A 273
1.79A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
TYR B 171
ALA B 116
ALA B 153
TYR B  83
1.43A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
TYR C  95
ALA C 116
ALA C 107
TYR B 268
1.44A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
TYR A  95
ALA A 116
ALA A 107
TYR C 268
1.35A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
ALA C 145
ALA C 114
TYR C 112
MET C 169
1.76A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
ALA A 145
ALA A 114
TYR A 112
MET A 169
1.63A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
TYR C 171
ALA C 116
ALA C 153
TYR C  83
1.65A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
TYR B  95
ALA B 116
ALA B 107
TYR A 268
1.40A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
ALA B 145
ALA B 114
TYR B 112
MET B 169
1.68A21.92
None
CL  B 502 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLN D4318
GLY D4347
SER D4325
SER D4320
ALA C6881
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLN B4318
GLY B4347
SER B4325
SER B4320
ALA A6881
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLN D4318
GLY D4347
SER D4325
SER D4320
ALA C6881
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLN B4318
GLY B4347
SER B4325
SER B4320
ALA A6881
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 146
SER A 121
SER A 123
ALA A 116
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 143
SER A 121
SER A 123
ALA A 116
1.67A
None
U5G  A 401 (-3.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLN B4318
GLY B4347
SER B4325
SER B4320
ALA A6881
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 5
TYR A 171
ALA A 116
ALA A 153
TYR A  83
1.64A21.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 5
ALA A 145
ALA A 114
TYR A 112
MET A 169
1.67A21.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6y84 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 146
SER A 121
SER A 123
ALA A 116
1.43A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY E 404
SER E 438
VAL E 350
ALA E 435
SER E 375
1.73A
DMS  E 902 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY A 404
SER A 438
VAL A 350
ALA A 435
SER A 375
1.74A
DMS  A 903 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TYR A 423
ALA A 348
ALA A 435
TYR A 508
1.63A21.49
None
None
None
DMS  A 903 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TYR E 423
ALA E 348
ALA E 435
TYR E 508
1.66A21.49
None
DMS  E 905 ( 4.0A)
None
DMS  E 902 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TYR E 423
ALA E 348
ALA E 435
TYR E 508
1.62A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY E 404
SER E 438
VAL E 350
ALA E 435
SER E 375
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 146
SER A 121
SER A 123
ALA A 116
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 143
SER A 121
SER A 123
ALA A 116
1.63A
None
P6N  A 502 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY A 404
SER A 438
VAL A 350
ALA A 435
SER A 375
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY E 404
SER E 438
VAL E 350
ALA E 435
SER E 375
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TYR A 423
ALA A 348
ALA A 435
TYR A 508
1.66A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TYR E 423
ALA E 348
ALA E 435
TYR E 508
1.66A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 143
SER A 121
SER A 123
ALA A 116
1.67A
None
PK8  A 401 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 146
SER A 121
SER A 123
ALA A 116
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY E  97
LEU E 127
ALA E 134
SER E 139
HIS E 138
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  78
SER C 128
VAL C  36
LEU C 108
HIS C 138
1.59A
None
MES  C 201 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		7btf NSP12
(SARS-CoV-2)		4 / 5
TYR A 619
ALA A 690
ALA A 625
TYR A 456
1.10A17.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 143
SER A 121
SER A 123
ALA A 116
1.67A
None
JRY  A 401 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLN A  69
GLY A 146
SER A 121
SER A 123
ALA A 116
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
TYR A 619
ALA A 690
ALA A 625
TYR A 456
1.12A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 698
SER A 635
VAL A 476
LEU A 576
ALA A 690
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 573
GLY A 683
SER A 564
THR A 567
ASP A 684
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 698
PHE A 694
ASP A 618
SER A 795
ALA A 797
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 573
GLY A 683
SER A 564
THR A 567
ASP A 684
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLN A 573
GLY A 683
SER A 564
THR A 567
ASP A 684
1.77A
None
U  T  10 ( 3.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
TYR A 619
ALA A 690
ALA A 625
TYR A 456
1.14A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLN A 698
SER A 635
VAL A 476
LEU A 576
ALA A 690
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLN A 573
GLY A 683
SER A 564
THR A 567
ASP A 684
1.72A
None
U  T  10 ( 3.1A)
None
None
None