Ligand ID: QPS


Drugbank ID:
DB00284
(Acarbose)


Indication:
For treatment and management of diabetes type II (used in combination therapy as a second or third line agent)

Get human targets for QPS in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'QPS'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
PHE A  56
SER A  13
ASN A  27
GLY A  17
ALA A  54
1.44A8.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
PHE A  56
SER A  13
ASN A  27
GLY A  17
ALA A  54
1.42A8.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		1uj1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
GLY B 143
LEU B 141
TYR B 126
SER B  10
HIS B 163
1.65A21.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		1uk4 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B 163
ASN B 133
GLN B 192
PRO B 184
GLY B 195
1.75A21.21
ATO  B2006 ( 4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		1uk4 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B 163
ASN B 133
GLN B 192
PRO B 184
GLY B 195
1.74A21.21
ATO  B2006 ( 4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
PHE A 140
SER A 139
SER B   1
GLY A 124
ALA A 116
1.79A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.78A18.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLU B 166
GLY B 170
GLY A  -1
GLY B 183
HIS B 163
1.53A18.97
I12  B2145 (-3.7A)
None
None
None
I12  B2145 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		1wyy E2 GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASP B1165
ASP B 932
ASN A1175
0.71A12.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		5 / 10
VAL B  85
SER A  92
SER A  13
GLY A 120
GLN B   2
1.54A7.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		5 / 10
VAL B  85
SER A  92
SER A  13
GLY A 120
GLN B   2
1.58A7.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B1272
ALA B1234
GLU B1240
ASP B1289
ARG B1131
1.61A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASP E  32
ASP D  17
ASN D  25
1.05A9.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
PHE B 314
SER B 310
SER B 321
VAL B 277
GLY B 261
1.52A10.03
GOL  B1004 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 10
PHE B 314
SER B 310
SER B 321
VAL B 277
GLY B 261
1.53A10.03
GOL  B1004 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
GLY C 229
GLY C 228
HIS C 276
ASN C 236
PRO C 214
1.56A15.68
GOL  C1009 (-4.0A)
GOL  C1009 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 10
VAL C  21
PHE G  97
SER C  62
GLY C  69
GLN G  93
1.76A6.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 10
VAL C  21
PHE G  97
SER C  62
GLY C  69
GLN G  93
1.78A6.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		2ajf ACE2
SPIKE PROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
VAL B  93
ASP F 393
ASP B  30
ASN B  33
ARG B 393
1.80A22.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		2ajf ACE2
SPIKE PROTEIN
(Homo
sapiens;
SARSr-CoV)		3 / 3
ASP E 393
ASP A  30
ASN A  90
1.17A13.07
None
None
NAG  A1090 (-1.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		2ajf ACE2
(Homo
sapiens)		5 / 12
TYR B 183
LEU B 179
ARG B 460
ALA B 501
PHE B 504
1.15A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2ajf ACE2
(Homo
sapiens)		5 / 10
VAL B 343
SER B  47
SER B  43
ASN B  63
VAL B  59
1.66A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		2ajf ACE2
SPIKE PROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 9
THR F 487
GLY F 488
GLY F 490
VAL F 394
GLU B  37
1.63A15.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2ajf ACE2
(Homo
sapiens)		5 / 12
VAL B 506
SER B 128
THR B 129
VAL B 172
GLY B 173
1.43A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		2ajf ACE2
(Homo
sapiens)		5 / 12
THR A 519
VAL A 404
THR A 453
HIS A 378
GLY A 395
1.74A20.39
None
None
None
ZN  A 901 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		2bx3 MAIN PROTEINASE
(SARS-COV
Sin2774)		5 / 12
GLY A 143
LEU A 141
GLY A  15
PRO A  99
PRO A  39
1.44A18.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
THR B 333
GLY A 336
THR B 330
GLY B 329
ASN B 286
1.45A11.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
GLY C 276
TYR B 269
ARG C 277
PRO C 280
GLY C 285
1.52A11.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
HIS C 301
TYR C 299
PHE C 364
HIS C 357
ASP C 289
1.65A11.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		2dd8 IGG HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
VAL S 337
ASP H  95
ASN S 409
ARG S 395
GLY S 403
1.70A16.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		6 / 12
THR L   6
GLY L  24
LEU L   5
VAL L  33
ASN L  26
ASN L  66
1.63A16.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR L 193
LEU L 118
ALA L 209
HIS L 190
ASP L 152
1.63A16.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		2dd8 IGG HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
VAL S 337
ASP H  95
ASN S 409
ARG S 395
GLY S 403
1.75A16.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR L 193
LEU L 118
ALA L 209
HIS L 190
ASP L 152
1.68A16.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLY B 124
VAL A 303
ASP A 153
ASN A 151
GLN A 127
1.48A18.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
GLY C  48
GLY C  47
HIS C  95
ASN C  55
PRO C  33
1.57A15.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 10
PHE C 133
SER C 129
SER C 140
VAL C  96
GLY C  80
1.57A9.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU C  81
LEU C  59
ALA C  69
GLU C  68
HIS C  18
1.22A18.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLY C 100
GLY C 101
LEU C 102
GLY C 257
HIS C 276
1.58A17.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
ASP B 106
ASP B  29
ASN K  40
1.23A13.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLU I  66
GLY M  50
HIS I  48
GLU M  60
PRO M 107
1.63A13.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLU N  66
PRO J  37
GLU I  60
PRO I  59
GLY I  50
1.60A13.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
THR J 101
VAL J  97
THR N  39
PRO M  59
GLY J  52
1.69A13.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
VAL T 116
PHE T 110
SER T  67
ASN T  62
GLY T 127
1.79A9.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		4 / 6
GLY A 116
ARG A  32
GLU A  76
ARG A 113
1.21A9.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
GLU A  76
HIS A   2
PRO A  98
ARG A  32
GLY A 116
1.48A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 10
PHE B  29
SER B  30
SER B  31
GLY B  26
ALA B  24
1.40A13.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		3 / 3
ASP D 182
ASP D  99
ASN D  57
1.22A16.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 12
LEU B 179
LEU B 205
ASP B 214
GLU B 213
ASP B 192
1.67A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 12
PHE B  29
SER B  30
SER B  31
GLY B  26
ALA B  24
1.31A13.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 6
PHE C 483
TYR C 481
ARG D 223
THR C 431
1.79A11.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 12
GLY D 148
LEU D 210
VAL D 238
ASP D 192
ASP D 214
1.50A16.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR B 103
GLN B 222
SER B 101
HIS B  35
THR A 487
1.74A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
HIS B 301
TYR B 299
PHE B 364
HIS B 357
ASP B 289
1.72A10.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		2gri NSP3
(SARSr-CoV)		5 / 12
VAL A  62
ASP A  93
ASN A  37
ARG A  23
GLU A  38
1.54A13.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 143
LEU A 141
GLY A  15
PRO A  99
PRO A  39
1.52A18.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 6
VAL A   5
TRP A  58
TRP A  86
THR A  83
1.66A15.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		2idy NSP3
(SARSr-CoV)		5 / 12
VAL A  62
ASP A  93
ASN A  37
ARG A  23
GLU A  38
1.61A13.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		5 / 12
HIS A  69
LEU A  58
LEU A  80
ASP A  66
ARG A  68
1.46A12.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 5
LEU A 105
PHE A  98
ARG A 106
TRP A 103
1.62A7.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		2kqv NSP3
(SARSr-CoV)		5 / 12
GLU A  20
HIS A  17
VAL A  82
GLU A  79
PRO A  80
1.61A16.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		5 / 10
THR A 136
VAL A  73
ASN A 141
GLY A 138
GLN A  84
1.72A9.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		5 / 10
THR A 136
VAL A  73
ASN A 141
GLY A 138
GLN A  84
1.66A9.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 10
PHE C 123
SER C 117
GLY C 100
ALA C  81
GLN C 130
1.42A15.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
PHE C 123
SER C 117
GLY C 100
ALA C  81
GLN C 130
1.42A15.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
GLU A  14
GLY A 124
LEU A 115
GLY A  71
ASN A  28
1.53A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
HIS B 163
ASN B 133
GLN B 192
PRO B 184
GLY B 195
1.79A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
HIS B 163
ASN B 133
GLN B 192
PRO B 184
GLY B 195
1.78A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
THR E 120
GLY E 140
LEU E 122
ASP F  36
HIS E  95
1.39A21.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 6
VAL B   5
TRP B  58
TRP B  86
THR B  83
1.75A15.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 10
THR A  33
VAL A  10
SER C 273
ASN C  73
GLY A  37
1.69A15.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
GLY B 143
LEU B 141
GLY B  15
PRO B  99
PRO B  39
1.54A19.81
XP1  B1304 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		2xyv NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
TRP A  88
PRO A  62
GLU B  60
PRO B  59
GLY B  50
1.77A18.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		2z3c REPLICASE
POLYPROTEIN 1AB
(PP1AB)
(SARSr-CoV;
synthetic
construct)		5 / 12
LEU B 310
VAL B 308
THR A  24
GLY A  23
ASP A 187
1.45A2.86
Z3E  B 309 ( 4.1A)
Z3E  B 309 ( 2.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 146
GLY A  29
LEU A  30
GLY A 138
PRO A 122
1.54A18.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 157
TYR B 182
TYR B 161
VAL B  13
CYH B  16
1.76A18.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		3d0g ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
VAL E 388
ASP E 393
GLN A  37
GLU A  38
GLY E 482
1.79A15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		3d0g ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
VAL E 388
ASP E 393
GLN A  37
GLU A  38
GLY E 482
1.76A15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU B 418
LEU B 423
ASP B 292
ASP B 367
ASP B 368
1.52A21.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
MET B 123
GLU B 181
GLU B 182
ARG B 115
1.68A21.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
VAL B 404
TRP B 349
HIS B 401
GLU B 398
GLY B 399
1.74A20.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
GLU B 375
TRP B 349
HIS B 401
GLU B 398
GLY B 399
1.72A20.24
 ZN  B 901 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
TYR A 183
LEU A 179
ARG A 460
ALA A 501
PHE A 504
1.09A21.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
VAL B 506
SER B 128
THR B 129
VAL B 172
GLY B 173
1.42A19.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
TRP B 349
MET B 332
TRP B  48
THR B  55
1.68A19.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
ASP B 509
ASP B 206
ASN B 210
1.08A20.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLU A 166
GLY A 124
HIS A 163
ASN A 142
PRO A 122
1.55A19.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.78A19.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLU B  14
GLY B 124
LEU B 115
GLY B  71
ASN B  28
1.57A19.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.75A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B 251
GLY A 179
HIS A 134
GLU A 178
PRO B 293
1.43A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 10
PHE C  56
SER C  13
ASN C  27
GLY C  17
ALA C  54
1.38A8.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
PHE C  56
SER C  13
ASN C  27
GLY C  17
ALA C  54
1.39A8.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B   2
GLY B 283
LEU B 282
GLY A 124
ARG B   4
1.58A18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A   2
GLY A 283
LEU A 282
GLY B 124
ARG A   4
1.20A18.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
THR A  26
SER A 123
GLY A 146
ALA A  28
GLN A  19
1.70A14.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASP A 153
ASN A 151
PHE A   8
GLN A 127
GLY A 109
1.66A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		3i6g HLA, A-2
MEMBRANE PROTEIN
(Homo
sapiens)		4 / 8
ARG D 131
ARG D 157
GLU A 166
LYS C   0
1.66A15.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_2
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		3i6k HLA, A-2
(Homo
sapiens)		5 / 9
TYR E  27
HIS E   3
ASP E 102
ARG E 181
PHE E 208
1.80A16.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3i6k BETA-2-MICROGLOBULIN
HLA, A-2
(Homo
sapiens)		5 / 10
THR A  94
PHE B  56
SER B  57
GLY A 120
GLN A  96
1.66A15.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		3i6k HLA, A-2
(Homo
sapiens)		5 / 12
THR E  80
GLY E  79
LEU E  78
THR E 142
GLN E  87
1.47A17.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3i6k BETA-2-MICROGLOBULIN
HLA, A-2
(Homo
sapiens)		4 / 6
VAL A 194
MET B  99
ARG A 202
THR A 228
1.57A15.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3i6l BETA-2-MICROGLOBULIN
HLA, A-24
(Homo
sapiens)		5 / 10
VAL E  85
SER D  92
SER D  13
GLY D 120
GLN E   2
1.56A7.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3i6l BETA-2-MICROGLOBULIN
HLA, A-24
(Homo
sapiens)		5 / 10
VAL E  85
SER D  92
SER D  13
GLY D 120
GLN E   2
1.51A7.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL D 157
TYR D 182
TYR D 161
VAL D  13
CYH D  16
1.73A18.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
THR A 190
VAL A 186
PHE A 185
ALA A 193
GLN A 192
1.61A15.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY B   2
GLY A 124
HIS A 163
ASN A 142
PRO A 122
1.55A18.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
VAL B 117
ASN B 263
ASP B 303
MET B 244
HIS B 172
1.65A14.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
VAL B 117
ASN B 263
ASP B 303
MET B 244
HIS B 172
1.71A14.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
VAL B 117
ASN B 263
ASP B 303
MET B 244
HIS B 172
1.71A14.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
THR B 275
TRP B  94
PRO B  97
CYH A 227
GLY A 228
1.65A18.27
None
None
None
ZN  A 901 (-2.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		3sci ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		3 / 3
ASP E 393
ASP A  30
ASN A  90
1.27A14.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		3sci ACE2
(Homo
sapiens)		5 / 12
GLU B 398
GLY B 205
PRO B 500
ARG B 204
GLU B 197
1.62A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		3sci ACE2
(Homo
sapiens)		4 / 8
MET A 123
GLU A 181
GLU A 182
ARG A 115
1.60A22.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		3sci ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 9
THR E 487
GLY E 488
GLY E 490
VAL E 394
GLU A  37
1.56A17.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3sci ACE2
(Homo
sapiens)		5 / 12
VAL B 506
SER B 128
THR B 129
VAL B 172
GLY B 173
1.45A19.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3scj ACE2
(Homo
sapiens)		4 / 6
TRP A 349
MET A 332
TRP A  48
THR A  55
1.78A19.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		3scj ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 9
THR E 487
GLY E 488
GLY E 490
VAL E 394
GLU A  37
1.66A14.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ASP B 367
LEU B 370
ASN B 290
TYR B 279
ASP B 292
1.79A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
TRP B 349
MET B 332
TRP B  48
THR B  55
1.69A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
GLU A 467
GLY A 466
TRP A 461
PRO A 451
VAL A 184
1.74A20.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
TYR B 183
LEU B 179
ARG B 460
ALA B 501
PHE B 504
1.09A21.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
ASP A 509
ASP A 206
ASN A 210
1.10A20.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A 418
LEU A 423
ASP A 292
ASP A 367
ASP A 368
1.57A21.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
THR A 282
HIS A 241
PRO A 590
VAL A 485
GLY A 272
1.74A20.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
VAL B 506
SER B 128
THR B 129
VAL B 172
GLY B 173
1.45A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
TRP A 473
GLU A 182
GLU A 181
ARG A 177
1.71A21.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 163
ASN A 133
GLN A 192
PRO A 184
GLY A 195
1.70A20.80
ECC  H   5 ( 4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 163
ASN A 133
GLN A 192
PRO A 184
GLY A 195
1.69A20.80
ECC  H   5 ( 4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.76A18.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA B 298
TYR A 118
PHE A 140
SER A 123
GLY A 124
1.60A19.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A  81
LEU A  59
ALA A  69
GLU A  68
HIS A  18
1.39A18.95
None
None
None
None
GOL  A 405 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 12
GLY B 100
GLY B 101
LEU B 102
GLY B 257
HIS B 276
1.63A18.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		5 / 12
THR A 201
GLY A 202
THR A 198
ASN A 178
GLN A 238
1.46A18.27
None
None
GOL  A 904 ( 3.4A)
DMS  A 905 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		5 / 12
LEU A  81
LEU A  59
ALA A  69
GLU A  68
HIS A  18
1.22A18.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		3 / 3
ASP A 144
ASP A 121
ASN A 267
1.25A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B 163
ASN B 133
GLN B 192
PRO B 184
GLY B 195
1.74A21.25
3A7  B 401 (-4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B 163
ASN B 133
GLN B 192
PRO B 184
GLY B 195
1.75A21.25
3A7  B 401 (-4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		3 / 3
ASP D 415
ASP D 390
ASN D 438
0.94A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		5c8s NSP10
(SARSr-CoV)		5 / 12
VAL A  97
ARG A  78
GLU A   6
PRO A 107
GLY A 109
1.69A14.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
VAL B  91
ASP B 273
PHE B 146
HIS B 148
HIS B  95
1.79A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
VAL B  91
ASP B 273
PHE B 146
HIS B 148
HIS B  95
1.72A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 10
GLY D 416
SER D 507
HIS D 427
PHE D 401
VAL D 282
1.78A21.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ASP D 358
ASN D 334
GLN D 354
PRO D 355
GLY D 333
1.79A21.61
None
SAM  D 605 ( 4.7A)
None
None
SAM  D 605 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		3 / 3
ASP D 415
ASP D 390
ASN D 438
0.91A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		5c8t NSP10
(SARSr-CoV)		5 / 12
LEU C  14
VAL C  13
GLY C   2
HIS C  80
ASN C  40
1.27A12.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
VAL B  91
ASP B 273
PHE B 146
HIS B 148
HIS B  95
1.76A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
GLU B 191
GLY B 189
TYR B 197
PRO B 158
GLY B  59
1.55A21.49
 MG  B 604 (-2.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5c8u NSP10
(SARSr-CoV)		5 / 12
THR C 111
VAL C  97
PHE C  68
THR C 102
GLY C 109
1.42A8.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 10
THR D 113
VAL D 115
SER D 194
GLY D  88
ALA D 274
1.71A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		5c8u GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 12
GLY D   6
LEU D   7
HIS C  80
ASN C  10
PRO D  20
1.51A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		5c8u NSP10
(SARSr-CoV)		5 / 12
GLY A  69
GLY A  70
LEU A  92
GLY A  50
PRO A 107
1.57A12.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		5e6j POLYUBIQUITIN-B
REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV;
synthetic
construct)		5 / 12
THR A  10
VAL A  42
THR F  12
HIS A  51
GLY A  39
1.72A18.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU D  81
LEU D  59
ALA D  69
GLU D  68
HIS D  18
1.37A18.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
THR A 278
SER A 115
VAL A  99
GLY A 100
GLN A 123
1.68A14.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
GLU A 191
GLY A 189
TYR A 197
PRO A 158
GLY A  59
1.51A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
THR A 428
GLY A 417
LEU A 419
VAL A 282
GLY A 505
1.50A22.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
LEU N  14
VAL N  13
GLY N   2
HIS N  80
ASN N  40
1.28A13.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 10
THR M 111
PHE M  68
SER M  67
ASN M  62
ALA M 104
1.64A8.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
VAL M  97
ARG M  78
GLU M   6
PRO M 107
GLY M 109
1.78A14.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		5r7z 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.76A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.77A13.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.56A13.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		5tl6 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU C 115
GLY C  91
TYR C  96
PRO C  81
PRO D 224
1.76A7.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU B  81
LEU B  59
ALA B  69
GLU B  68
HIS B  18
1.19A18.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		5tl7 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus;
SARSr-CoV)		5 / 12
GLY B 164
GLY A 154
LEU B 163
GLY B  39
ASN B 111
1.59A18.60
None
AYE  A 155 ( 2.4A)
AYE  A 155 ( 4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		5tl7 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus;
SARSr-CoV)		5 / 12
GLY C 136
LEU C 135
GLY C 126
GLU D 204
PRO C 142
1.36A8.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 581
THR A 678
GLY A 653
ALA A 633
GLN A 599
1.48A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY C 634
VAL C 628
THR A 841
GLY A 839
ASP A 719
1.34A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASP C 454
ASP C 407
ASN A 357
1.10A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
THR A 289
VAL A 153
THR A 259
PRO A 320
VAL A 109
1.40A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
ALA A  92
ARG A 307
SER A 302
HIS A 298
THR A 209
1.58A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLU A 184
GLY A 199
TYR A  88
TYR A  41
PRO A 259
1.80A18.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
THR B  92
VAL B 205
SER B 211
SER B  36
VAL B  66
1.73A22.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		3 / 3
ASP B  85
ASP A 415
ASN B 951
1.01A18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
GLY C 613
GLY A  61
ASN C 637
PRO A  59
GLN C 636
1.46A18.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
ALA B  92
ARG B 307
SER B 302
HIS B 298
THR B 209
1.57A17.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
VAL A1015
PHE A1034
SER A 798
GLY A 862
ALA A 864
1.64A22.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL A 958
ASP C 554
ASN A 838
ASN A 960
GLY A 726
1.78A19.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
THR C 616
VAL C 606
THR A 729
VAL C 601
GLY C 580
1.64A18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL A 958
ASP C 554
ASN A 838
ASN A 960
GLY A 726
1.79A19.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLY A 634
VAL A 628
THR B 841
GLY B 839
ASP B 719
1.40A18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLY C 580
GLY C 579
GLY C 298
PRO C 586
PRO C 617
1.54A18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLU C 970
GLY B 368
VAL B 420
PRO B 399
GLY B 418
1.79A18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL B 328
SER B 500
ASN B 381
VAL B 510
ALA B 350
1.38A22.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
VAL B  50
ASP B 664
HIS B 348
ASN B 342
GLY B  79
1.67A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		5x5c S PROTEIN
(MERS-CoV)		6 / 12
GLY B 613
LEU B 651
VAL B 616
GLY B 578
ASP B 580
ASN B 637
1.73A18.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
VAL B  50
ASP B 664
HIS B 348
ASN B 342
GLY B  79
1.67A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
THR C 289
VAL C 153
THR C 259
PRO C 320
VAL C 109
1.41A18.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
THR B 559
VAL B 562
SER B 516
ASN B 528
GLY B 534
1.58A21.88
THR  B 559 ( 0.8A)
VAL  B 562 ( 0.6A)
SER  B 516 ( 0.0A)
ASN  B 528 ( 0.6A)
GLY  B 534 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLU B 184
GLY B 199
TYR B  88
TYR B  41
PRO B 259
1.78A19.90
GLU  B 184 ( 0.5A)
GLY  B 199 ( 0.0A)
TYR  B  88 ( 1.3A)
TYR  B  41 ( 1.3A)
PRO  B 259 ( 1.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL C 496
ASN C 424
GLN C 492
PRO C 493
GLY C 391
1.78A19.87
VAL  C 496 ( 0.6A)
ASN  C 424 ( 0.6A)
GLN  C 492 ( 0.6A)
PRO  C 493 ( 1.1A)
GLY  C 391 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL C 496
ASN C 424
GLN C 492
PRO C 493
GLY C 391
1.79A19.87
VAL  C 496 ( 0.6A)
ASN  C 424 ( 0.6A)
GLN  C 492 ( 0.6A)
PRO  C 493 ( 1.1A)
GLY  C 391 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
VAL A 117
ASN A 263
ASP A 303
MET A 244
HIS A 172
1.69A14.85
None
NA  A 404 (-2.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 12
THR A 943
ASN a  12
VAL a  13
ALA A 938
GLN A 939
1.20A6.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 10
THR A 943
PHE a  15
ASN a  12
ALA A 938
GLN A 939
1.69A6.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY B 225
TYR C 410
ARG C 342
PRO C 450
GLY B 192
1.57A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP B  57
LEU B 257
TYR B 195
ASP B 191
PHE B  83
1.48A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6acg ACE2
(Homo
sapiens)		5 / 12
THR D 282
HIS D 241
PRO D 590
VAL D 485
GLY D 272
1.73A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ARG A1001
GLU B 999
GLU A 999
ARG C1001
1.77A20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY C 873
LEU C 876
GLY C 890
ASN A1090
PRO A1051
1.40A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
THR B  92
VAL B 205
SER B 211
SER B  36
VAL B  66
1.55A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 382
THR A 372
ASN A 375
GLY A 512
ALA A 350
1.22A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE A 305
ASN A 304
ASP C 719
MET C 722
ASP C 727
1.70A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASP B  23
ASP B 134
ASN B 155
1.07A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
VAL B1015
PHE B1034
SER B 798
GLY B 862
ALA B 864
1.48A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 934
ASN A 937
ARG C 758
GLU C 762
GLU A 999
1.52A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6acj ACE2
(Homo
sapiens)		3 / 3
ASP D 509
ASP D 206
ASN D 210
1.10A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		6acj ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 9
THR C 487
GLY C 488
GLY C 490
VAL C 394
GLU D  37
1.59A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL B 581
THR B 535
GLY B 534
ASP A 719
ASN A 721
1.32A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6acj ACE2
(Homo
sapiens)		5 / 12
TYR D 183
LEU D 179
ARG D 460
ALA D 501
PHE D 504
1.12A22.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU C 978
LEU C 959
ALA C 954
ASP A 557
ARG A 553
1.56A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A  97
ASP A 154
ASN A 135
ARG A 232
GLY A  77
1.58A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		6ack ACE2
(Homo
sapiens)		5 / 12
ALA D 533
PHE D 315
SER D 411
HIS D 373
THR D 414
1.64A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU B 959
ARG C 306
ASP B 727
PHE C 578
ASP B 719
1.64A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ack ACE2
(Homo
sapiens)		5 / 12
THR D 453
THR D 517
GLY D 399
HIS D 505
ASN D 277
1.46A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER C 607
THR C 608
VAL C 307
ALA C 577
GLN A 835
1.49A23.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY C 580
GLY C 579
GLY C 298
PRO C 586
PRO C 617
1.63A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL C 313
ASP A 961
ASN C 530
GLN C 550
PRO C 565
1.80A19.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
HIS C  33
ASN C  29
GLN C  26
PRO C  28
GLY C  77
1.76A19.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
VAL B1015
PHE B1034
SER B 798
GLY B 862
ALA B 864
1.58A23.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY B 634
VAL B 628
THR C 841
GLY C 839
ASP C 719
1.32A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
VAL B1015
PHE B1034
SER B 798
GLY B 862
ALA B 864
1.40A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
VAL C 328
PHE C 329
SER C 500
ASN C 381
VAL C 510
1.66A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY C 634
VAL C 628
THR A 841
GLY A 839
ASP A 719
1.21A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY A 580
GLY A 579
GLY A 298
PRO A 586
PRO A 617
1.57A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
THR C 716
GLY C 820
LEU C 840
TYR C 989
VAL B 555
1.65A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
HIS B 149
ASN B 155
ASN B 109
ARG B 126
GLU B 162
1.37A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL B1111
THR B1058
ASN B 692
ALA C 881
GLN C 902
1.23A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLN C 614
PHE C 578
ASP A 719
ASN A 721
PHE C 305
1.42A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		6cs2 ACE2
SPIKE
GLYCOPROTEIN,FIBRITI
N
(Homo
sapiens;
SARSr-CoV)		5 / 9
THR B 487
GLY B 488
GLY B 490
VAL B 394
GLU D  37
1.68A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
THR B 809
VAL B 934
HIS B1040
PRO B 789
GLY B 928
1.67A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6cs2 ACE2
(Homo
sapiens)		5 / 12
LEU D 418
LEU D 423
ASP D 292
ASP D 367
ASP D 368
1.43A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLN B1124
ASN B1101
ASP B1100
ASP B1121
HIS B1065
1.61A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6cs2 ACE2
(Homo
sapiens)		4 / 6
TRP D 163
GLY D 147
ASN D 134
PRO D 146
1.36A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLN B1124
ASN B1101
ASP B1100
ASP B1121
HIS B1065
1.60A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL C 525
ASP C 600
PHE C 578
ASN C 526
GLY C 534
1.66A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		6cs2 ACE2
(Homo
sapiens)		5 / 12
ALA D 533
PHE D 315
SER D 411
HIS D 373
THR D 414
1.58A19.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
ASP B 850
ASP B 790
ASN B 783
0.79A19.80
None
None
NAG  B1316 (-1.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY C 892
TYR A 886
TRP A 868
PRO A 879
PRO C1051
1.58A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLN B1124
ASN B1101
ASP B1100
ASP B1121
HIS B1065
1.70A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QPU_B_QPSB3000_1
(ALPHA-AMYLASE TYPE A
ISOZYME)		6jyt HELICASE
(SARSr-CoV)		5 / 9
ASP A 113
THR B 137
ASP B 105
ALA B 134
TRP B 114
1.69A21.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6jyt HELICASE
(SARSr-CoV)		5 / 12
VAL A 544
THR A 440
GLY A 439
ASN A 562
GLN A 404
1.44A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6jyt HELICASE
(SARSr-CoV)		5 / 12
GLN B 270
ASP B 435
MET B 436
HIS B 245
HIS B 395
1.78A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6jyt HELICASE
(SARSr-CoV)		5 / 12
VAL A 449
THR A 532
TYR A 541
PRO A 529
GLY A 285
1.59A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6jyt HELICASE
(SARSr-CoV)		5 / 12
GLN B 270
ASP B 435
MET B 436
HIS B 245
HIS B 395
1.73A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6jyt HELICASE
(SARSr-CoV)		5 / 10
VAL B 521
PHE B 511
VAL B 496
GLY B 494
GLN B 518
1.80A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6lu7 MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 261
ASP A 197
ASN A 203
GLN A 110
PRO A 293
1.80A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 10
THR F 941
GLY F 946
LEU F 945
SER E 939
VAL F 952
1.57A13.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		3 / 3
ASP D 950
ASP D1184
ASN D1192
0.92A10.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.77A19.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.62A19.09
ELL  D   3 (-3.6A)
None
None
None
ALC  D   2 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6m0j ACE2
(Homo
sapiens)		5 / 12
LEU A 418
LEU A 423
ASP A 292
ASP A 367
ASP A 368
1.50A22.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.67A19.66
ELL  D   3 (-3.6A)
None
None
None
N0A  D   2 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.78A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		5 / 12
VAL E 510
ASN E 439
GLN E 506
PRO E 507
GLY E 404
1.73A18.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		5 / 12
VAL E 510
ASN E 439
GLN E 506
PRO E 507
GLY E 404
1.72A18.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
GLU C  89
GLY C 284
GLY C 285
LEU C 286
GLY C 490
1.27A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		6m17 ACE2
(Homo
sapiens)		4 / 8
MET B 123
GLU B 181
GLU B 182
ARG B 115
1.57A22.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		3 / 3
ASP A 564
ASP A 164
ASN A 158
1.04A21.08
None
None
NAG  A 701 (-2.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6m18 ACE2
(Homo
sapiens)		5 / 12
LEU D 450
TYR D 516
GLU D 232
HIS D 228
ASP D 225
1.70A22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6m18 ACE2
(Homo
sapiens)		5 / 12
GLY D 575
LEU D 570
GLY D 551
GLN D 531
PRO D 583
1.61A21.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6m1d ACE2
(Homo
sapiens)		5 / 12
GLU D 310
GLY D 422
HIS D 417
PRO D 346
PRO D 415
1.73A21.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m1d ACE2
(Homo
sapiens)		5 / 12
SER D 128
THR D 129
VAL D 172
GLY D 173
ALA D 501
1.44A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 8
ARG A  97
ARG A  32
GLU A  28
GLU A  27
1.65A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
THR C 396
GLY C 395
VAL C  55
GLY C 478
ASN C  54
1.18A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
THR C 180
TYR C 139
THR C 396
TRP C 150
VAL C 163
1.61A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 10
THR A 212
VAL A 440
SER A 288
SER A 291
TRP A  35
1.80A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
GLU A 217
ARG A 214
GLY A 215
THR A 219
MET A 436
1.79A22.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m1d ACE2
(Homo
sapiens)		4 / 6
VAL B 485
TRP B 275
ARG B 273
THR B 519
1.65A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY C 146
LEU C  27
GLY C  15
ASN C 119
ASN C 142
1.75A18.86
None
None
None
None
3WL  C 401 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C 114
PHE C 150
SER C  10
VAL A 125
ALA C   7
1.77A15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY D 143
LEU D  27
VAL D  20
GLY D 170
HIS D  41
1.62A18.86
3WL  D 401 (-3.4A)
None
None
None
3WL  D 401 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY B 143
LEU B  27
VAL B  20
GLY B 170
HIS B  41
1.73A18.86
3WL  B 401 (-3.4A)
None
None
None
3WL  B 401 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY C 143
LEU C  27
VAL C  20
GLY C 170
HIS C  41
1.65A18.86
3WL  C 401 (-3.4A)
None
None
None
3WL  C 401 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
THR B 135
THR B 169
HIS B 163
ASN B 180
GLN B 192
1.49A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
THR A 135
THR A 169
HIS A 163
ASN A 180
GLN A 192
1.50A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.71A18.86
3WL  A 401 (-3.3A)
None
None
None
3WL  A 401 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 146
LEU A  27
GLY A  15
ASN A 119
ASN A 142
1.77A18.86
None
None
None
None
3WL  A 401 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL D 114
PHE D 150
SER D  10
VAL B 125
ALA D   7
1.78A15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B 157
TYR B 182
TYR B 161
VAL B  13
CYH B  16
1.80A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY B 146
LEU B  27
GLY B  15
ASN B 119
ASN B 142
1.77A18.86
None
None
None
None
3WL  B 401 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.79A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.68A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ASP C 104
ASP C  64
ASN C 127
1.12A12.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
THR A 136
VAL A  73
ASN A 141
GLY A 138
GLN A  84
1.78A8.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
THR C 136
VAL C  73
ASN C 141
GLY C 138
GLN C  84
1.67A8.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m71 NSP12
(SARS-CoV-2)		5 / 12
THR A 148
LEU A 212
VAL A 182
ASP A 211
ASN A 213
1.79A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		6m71 NSP12
(SARS-CoV-2)		5 / 10
THR A 680
GLY A 678
LEU A 663
PHE A 694
VAL A 315
1.50A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m71 NSP12
NSP7
(SARS-CoV-2)		5 / 12
VAL A 424
PHE A 429
SER C   4
THR C  45
GLY A 432
1.77A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 758
VAL A 588
THR A 680
ASP A 761
ASN A 695
1.80A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 758
VAL A 588
GLY A 679
ASP A 623
ASN A 695
1.71A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
THR A 710
PHE A 745
ASN A 767
VAL A 776
GLY A 774
1.77A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
THR A 710
PHE A 745
ASN A 767
VAL A 776
GLY A 774
1.75A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 387
TYR B 149
LEU B 122
ALA A 399
ASP A 390
1.76A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m71 NSP12
(SARS-CoV-2)		5 / 12
GLY A 179
LEU A 178
ASP A 170
ASN A 150
ASN A 213
1.61A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m71 NSP12
(SARS-CoV-2)		5 / 10
THR A 710
PHE A 745
ASN A 767
VAL A 776
GLY A 774
1.73A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR B 616
VAL B 606
THR A 729
VAL B 601
GLY B 580
1.73A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
ASP C 312
ASP B 727
ASN C 304
1.28A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP A 376
ASP A 312
ASN A 526
GLU C 730
PRO A 309
1.56A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 581
THR A 535
GLY A 534
ASP C 719
ASN C 721
1.35A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ARG B 758
ARG B1001
GLU B 755
LYS B 715
1.45A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL C 990
ASP C 727
ASN C 746
GLN A 301
GLY C 751
1.59A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY C 751
LEU C 749
PRO A 617
GLU A 285
ARG C 747
1.41A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A1015
PHE A1034
SER A 798
GLY A 862
ALA A 864
1.52A22.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
VAL A1015
PHE A1034
SER A 798
GLY A 862
ALA A 864
1.41A22.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 10
VAL H 166
SER H 193
SER L 181
ASN L 142
GLY H 176
1.73A13.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 10
VAL H 166
SER H 193
SER L 181
ASN L 142
GLY H 176
1.66A13.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 10
THR L  77
GLY L  69
LEU L  78
SER L  25
VAL L  63
1.66A17.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL H 221
THR H 121
PRO L  45
VAL H 135
GLY H 132
1.67A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		6nur NSP12
(SARSr-CoV)		5 / 12
ALA A 253
ARG A 183
TYR A 286
PHE A 287
THR A 248
1.75A19.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6nur NSP12
(SARSr-CoV)		5 / 12
THR A 611
VAL A 605
VAL A 763
GLU A 802
GLY A 808
1.55A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		6nus NSP12
(SARSr-CoV)		5 / 10
THR A 680
GLY A 678
LEU A 663
PHE A 694
VAL A 315
1.51A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL B1068
HIS B1064
GLU C1031
GLN C 784
GLY C 889
1.77A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP B1139
LEU B1141
GLN B1142
ASP C1139
ASP C1118
1.75A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL B 130
PHE B 168
SER A 359
THR A 393
GLY B 199
1.39A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY A 889
LEU A1034
VAL A 785
GLY A 908
GLN A 901
1.51A18.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
THR C 778
GLY C1059
HIS C1058
VAL C 952
GLU C 773
1.64A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6vw1 ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
ASP F 406
ASP B  30
ASN B  90
1.28A15.28
None
None
NAG  B 701 (-1.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		6vw1 ACE2
(Homo
sapiens)		4 / 8
MET A 123
GLU A 181
GLU A 182
ARG A 115
1.65A22.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vw1 ACE2
(Homo
sapiens)		4 / 6
TRP B 349
MET B 332
TRP B  48
THR B  55
1.72A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL F 367
PHE F 338
ASN F 334
VAL F 362
ALA F 363
1.33A12.74
NAG  F 602 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6vw1 ACE2
(Homo
sapiens)		5 / 12
LEU A 418
LEU A 423
ASP A 292
ASP A 367
ASP A 368
1.47A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
VAL A   6
TRP A  59
TRP A  87
THR A  84
1.79A16.78
None
GOL  A 401 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A 298
GLU A 203
ARG A 207
GLN A 160
PRO A 158
1.43A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY B  47
GLY B  46
HIS B  94
ASN B  54
PRO B  32
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY B  51
LEU B  53
VAL B  24
THR A  71
HIS B  94
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 10
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 10
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.57A
None
None
None
None
SO4  A 201 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
THR A  71
SER B  65
ASN B  59
GLY B  46
ALA B  50
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
THR A  71
SER B  65
ASN B  59
GLY B  46
ALA B  50
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
ASN B 115
VAL B  95
ALA B  39
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B  53
VAL B  35
THR A  71
ASN B  54
GLN B  62
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.54A
None
None
None
None
SO4  A 201 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 10
THR A  71
SER B  65
ASN B  59
GLY B  46
ALA B  50
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.58A
None
None
None
None
SO4  A 201 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP A 775
ASP A 867
ASN A 824
1.12A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP A1139
LEU A1141
GLN A1142
ASP C1118
ASP A1118
1.61A22.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP A1139
LEU A1141
GLN A1142
ASP C1118
ASP A1118
1.58A22.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY A 889
LEU A1034
VAL A 785
GLY A 908
GLN A 901
1.46A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE C1095
SER C1097
THR C1076
ASN C 710
GLY C1131
1.55A22.09
None
None
None
None
NAG  C1311 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP B 405
ASN C 439
ASN C 448
PRO C 499
GLY C 496
1.73A18.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
PHE C1095
SER C1097
ASN C 710
GLY C1131
ALA C1080
1.70A22.09
None
None
None
NAG  C1311 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP C1139
LEU C1141
GLN C1142
ASP B1118
ASP C1118
1.43A22.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL C 576
PHE C 565
ASN A 978
GLY C 545
GLN C 564
1.71A22.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A1040
THR A1105
TYR B 904
PRO A1079
GLY B 891
1.70A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
PHE A 592
SER A 591
ASN A 616
VAL A 615
GLY A 648
1.80A22.11
None
None
NAG  A1309 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 889
LEU C1034
VAL C 785
GLY C 908
GLN C 901
1.48A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL B 610
THR B 618
ASN B 616
VAL B 615
GLY B 648
1.49A22.11
None
NAG  B1308 (-3.5A)
NAG  B1308 (-2.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP A 364
ASP A 389
ASN A 540
0.89A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP C1139
LEU C1141
GLN C1142
ASP B1118
ASP C1118
1.42A22.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
THR A 778
GLY A1059
HIS A1058
VAL A 952
GLU A 773
1.62A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 10
THR D 135
VAL D  72
ASN D 140
GLY D 137
GLN D  83
1.76A8.68
None
None
None
None
GOL  D 204 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		3 / 3
ASP D 103
ASP D  63
ASN D 126
1.01A11.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w02 NSP3
(SARS-CoV-2)		5 / 12
LEU B 126
LEU B 140
ALA B 129
ASP B 157
ASP B 162
1.77A14.33
APR  B 201 (-4.8A)
None
APR  B 201 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL H  67
PHE H  63
SER H  60
THR L  94
GLY H  35
1.56A9.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
PHE L 116
SER L 174
VAL H 182
GLY H 139
ALA H 137
1.77A9.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
PHE L 116
SER L 174
VAL H 181
GLY H 139
ALA H 137
1.76A9.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL H  67
PHE H  63
SER H  60
THR L  94
GLY H  35
1.47A9.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
VAL C 401
SER C 443
THR C 500
ASN C 501
GLY C 504
1.78A10.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
PHE L 116
SER L 174
VAL H 182
GLY H 139
ALA H 137
1.80A9.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU C 390
GLY H  95
ASP H 101
ASP C 389
ASN C 388
1.77A15.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
THR H 116
VAL H  11
THR H 151
ASN H 199
GLY H 118
1.63A9.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
TYR L 173
PRO L  40
VAL L 196
PRO L 113
GLY L 200
1.77A14.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
THR H 116
VAL H  11
THR H 151
ASN H 199
GLY H 118
1.64A9.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 10
THR L  72
GLY L  64
LEU L  73
SER L  25
VAL L  58
1.69A17.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL L 163
PHE L 139
SER L 114
VAL L 196
ALA L 144
1.74A9.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6w4h NSP10
NSP16
(SARS-CoV-2)		5 / 12
TRP A6886
PRO A6860
GLU B4313
PRO B4312
GLY B4303
1.77A18.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6876
THR A6889
GLY A6890
ASP A6895
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
TRP A6886
PRO A6860
GLU B4313
PRO B4312
GLY B4303
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6w61 NSP10
(SARS-CoV-2)		5 / 12
GLY B4322
GLY B4323
LEU B4345
GLY B4303
PRO B4360
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6879
THR A6891
GLY A6890
ASP A6906
GLN A6885
1.77A
SAM  A7104 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4323
GLY B4347
GLY A6837
PRO A6835
GLN B4351
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.73A
X77  A 401 (-3.6A)
X77  A 401 ( 3.9A)
None
None
X77  A 401 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 10
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.57A
AMP  A 201 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.78A
None
None
MES  B 201 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
ASN A 115
VAL A  95
ALA A  39
1.76A
AMP  A 201 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
ALA A  39
1.78A
AMP  A 201 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.78A
None
None
MES  B 201 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.72A
MES  B 201 ( 3.4A)
MES  B 201 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 10
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.73A
MES  B 201 ( 3.4A)
MES  B 201 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
ALA A  39
1.80A
AMP  A 201 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.73A
MES  B 201 ( 3.4A)
MES  B 201 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.57A
AMP  A 201 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY B  47
GLY B  46
HIS B  94
ASN B  54
PRO B  32
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 126
LEU B 140
ALA B 129
ASP B 157
ASP B 162
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.61A
AMP  A 201 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP16
(SARS-CoV-2)		5 / 12
THR A6915
LEU A7093
VAL C7086
GLY A6946
ASN C6920
1.78A12.77
None
None
None
FMT  A7108 ( 4.8A)
FMT  C7106 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP16
(SARS-CoV-2)		5 / 12
THR C6915
LEU C7093
VAL A7086
GLY C6946
ASN A6920
1.66A12.77
None
None
None
FMT  C7115 ( 3.0A)
FMT  A7106 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4322
VAL C6876
THR C6889
GLY C6890
ASP C6895
1.47A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6876
THR A6889
GLY A6890
ASP A6895
1.54A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6879
THR C6891
GLY C6890
ASP C6906
GLN C6885
1.78A12.77
SAM  C7105 ( 3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4323
VAL C6876
THR C6889
GLY C6890
ASP C6895
1.75A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
TRP C6886
PRO C6860
GLU D4313
PRO D4312
GLY D4303
1.74A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w75 NSP10
(SARS-CoV-2)		5 / 12
THR B4364
VAL B4350
SER B4325
THR B4292
GLY B4362
1.72A9.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4323
GLY B4347
GLY A6837
PRO A6835
GLN B4351
1.76A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4323
GLY D4347
GLY C6837
PRO C6835
GLN D4351
1.77A12.42
None
None
FMT  D4404 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
TRP A6886
PRO A6860
GLU B4313
PRO B4312
GLY B4303
1.77A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP16
(SARS-CoV-2)		5 / 12
THR C6908
LEU C6893
GLY C6875
HIS C6867
ASN A7096
1.44A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6879
THR A6891
GLY A6890
ASP A6906
GLN A6885
1.76A12.77
SAM  A7102 ( 3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
THR A6908
THR A6880
ASP A6900
HIS B4333
ASN A6899
1.62A12.77
None
None
None
None
SAM  A7102 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6879
VAL C6876
THR C6891
GLY C6890
GLN C6885
1.76A12.77
SAM  C7105 ( 3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASP B 164
PHE B 173
VAL B 202
ASP B 302
PHE B 304
1.64A15.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  80
TYR A  56
ALA A  68
GLU A  67
HIS A  17
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  64
VAL A  66
THR A  42
ASP A  61
ASN A  60
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B  80
LEU B  58
ALA B  68
GLU B  67
HIS B  17
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A  56
LEU A  80
ALA A  68
GLU A  67
HIS A  17
1.60A19.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C  64
VAL C  66
THR C  42
GLY C  28
ASP C  61
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B 150
TYR B  83
ALA B 135
GLU B 143
ASP B  37
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C  80
LEU C  58
ALA C  68
GLU C  67
HIS C  17
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLU B 167
GLY B 163
TYR B 171
PRO B 129
GLY B 160
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLY B 163
GLY A 271
HIS B 272
ASN B 110
PRO A 248
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C  87
TYR C  83
ALA C 145
GLU C 143
ASP C 134
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
ASP B  61
ASP B  12
ASN B 146
1.51A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
THR A 265
GLY A 266
ASP A 286
ASN C 267
ASN A 109
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B  80
TYR B  56
ALA B  68
GLU B  67
HIS B  17
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  80
LEU A  58
ALA A  68
GLU A  67
HIS A  17
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASP A 164
PHE A 173
VAL A 202
ASP A 302
PHE A 304
1.66A15.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASP C 164
PHE C 173
VAL C 202
ASP C 302
PHE C 304
1.62A15.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
ASP A  61
ASP A  12
ASN A 146
1.60A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 150
TYR A  83
ALA A 135
GLU A 143
ASP A  37
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 150
TYR A  83
ASP A 134
ALA A 135
GLU A 143
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C 150
TYR C  83
ALA C 135
GLU C 143
ASP C  37
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.73A
MES  A 201 (-2.5A)
MES  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.74A
MES  A 201 (-2.5A)
MES  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.78A
None
None
MES  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wcf NSP3
(SARS-CoV-2)		5 / 10
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.75A
MES  A 201 (-2.5A)
MES  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.78A
None
None
MES  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wcf NSP3
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.57A
MES  A 202 (-3.4A)
MES  A 202 (-4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 10
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A  48
GLY A  47
HIS A  94
ASN A  54
PRO A  32
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
ASN A 115
VAL A  95
ALA A  39
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
ASN A 115
VAL A  95
ALA A  39
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 126
LEU A 140
ALA A 129
ASP A 157
ASP A 162
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
ALA A  39
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wey NSP3
(SARS-CoV-2)		5 / 10
PHE A 336
SER A 332
SER A 343
VAL A 299
GLY A 283
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wey NSP3
(SARS-CoV-2)		5 / 12
THR A 350
VAL A 346
SER A 332
VAL A 299
ALA A 316
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wey NSP3
(SARS-CoV-2)		5 / 12
GLY A 251
GLY A 250
HIS A 298
ASN A 258
PRO A 236
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wey NSP3
(SARS-CoV-2)		5 / 12
PHE A 336
SER A 332
SER A 343
VAL A 299
GLY A 283
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wey NSP3
(SARS-CoV-2)		5 / 12
THR A 350
VAL A 346
SER A 332
VAL A 299
ALA A 316
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wey NSP3
(SARS-CoV-2)		5 / 12
PHE A 336
SER A 332
SER A 343
VAL A 299
GLY A 283
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS B 300
TYR B 298
PHE B 363
HIS B 356
ASP B 288
1.71A10.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR F 332
GLY F 321
THR F 325
GLY F 328
ASN E 354
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS D 300
TYR D 298
PHE D 363
HIS D 356
ASP D 288
1.79A10.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS E 300
TYR E 298
PHE E 363
HIS E 356
ASP E 288
1.78A10.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR A 332
GLY A 321
THR A 325
GLY A 328
ASN B 354
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR B 332
GLY B 321
THR B 325
GLY B 328
ASN A 354
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS A 300
TYR A 298
PHE A 363
HIS A 356
ASP A 288
1.70A10.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY A 321
LEU B 353
THR A 325
ASP B 341
ASN B 354
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS C 300
TYR C 298
PHE C 363
HIS C 356
ASP C 288
1.70A10.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY C 321
LEU D 353
THR C 325
ASP D 341
ASN D 354
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR C 332
GLY C 321
THR C 325
GLY C 328
ASN D 354
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
THR C6908
LEU C6893
GLY C6875
HIS C6867
ASN A7096
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4323
GLY B4347
GLY A6837
PRO A6835
GLN B4351
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY C6879
THR C6891
GLY C6890
ASP C6906
GLN C6885
1.76A
SAH  C7102 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY D4323
VAL C6876
THR C6889
GLY C6890
ASP C6895
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
TRP C6886
PRO C6860
GLU D4313
PRO D4312
GLY D4303
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
THR A6908
LEU A6893
GLY A6875
HIS A6867
ASN C7096
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY C6879
VAL C6876
THR C6891
GLY C6890
GLN C6885
1.79A
SAH  C7102 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
THR A6908
THR A6880
ASP A6900
HIS B4333
ASN A6899
1.46A
None
None
None
None
SAH  A7102 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
THR C6915
LEU C7093
VAL A7086
GLY C6946
ASN A6920
1.64A
FMT  C7107 (-3.7A)
None
None
None
FMT  A7106 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
THR A6908
THR A6880
GLY A6879
ASP A6900
ASN A6899
1.51A
None
None
SAH  A7102 (-3.5A)
None
SAH  A7102 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6876
THR A6889
GLY A6890
ASP A6895
1.55A
None
None
NA  A7101 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
TRP A6886
PRO A6860
GLU B4313
PRO B4312
GLY B4303
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY A6875
GLY D4341
ASP A6897
ASN A6899
ASN A6841
1.77A
None
None
SAH  A7102 (-2.6A)
SAH  A7102 (-4.0A)
SAH  A7102 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY D4322
VAL C6876
THR C6889
GLY C6890
ASP C6895
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6879
THR A6891
GLY A6890
ASP A6906
GLN A6885
1.75A
SAH  A7102 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR D 115
GLY D 147
THR D 141
ASN D  75
ASN D 154
1.73A
None
None
None
MES  D 201 (-3.0A)
MES  D 201 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLU D  62
GLY D  60
GLY D  71
PRO D 162
PRO A  80
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR B 135
VAL B  72
ASN B 140
GLY B 137
GLN B  83
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU D 121
THR D 148
GLY D 147
ASP D 144
ASN D 126
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR A 141
LEU A 139
THR A 115
GLY A 147
HIS D  59
1.63A
None
None
None
None
ZN  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU C 121
THR C 148
GLY C 147
ASP C 144
ASN C 126
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
THR C 135
VAL C  72
ASN C 140
GLY C 137
GLN C  83
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ASP B 103
ASP B  63
ASN B 126
1.30A11.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR A 135
VAL A  72
ASN A 140
GLY A 137
GLN A  83
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
THR B 135
VAL B  72
ASN B 140
GLY B 137
GLN B  83
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR C 135
VAL C  72
ASN C 140
GLY C 137
GLN C  83
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR B 115
GLY B 147
THR B 141
ASN B  75
ASN B 154
1.69A
None
None
None
MES  B 201 (-3.1A)
MES  B 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
THR A 135
VAL A  72
ASN A 140
GLY A 137
GLN A  83
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
TRP C6886
PRO C6860
GLU D4313
PRO D4312
GLY D4303
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4323
GLY D4347
GLY C6837
PRO C6835
GLN D4351
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLY C6879
VAL C6876
THR C6891
GLY C6890
GLN C6885
1.77A
SFG  C7103 ( 3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4322
VAL C6876
THR C6889
GLY C6890
ASP C6895
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4323
GLY B4347
GLY A6837
PRO A6835
GLN B4351
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP16
(SARS-CoV-2)		5 / 12
THR C6908
LEU C6893
GLY C6875
HIS C6867
ASN A7096
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLY C6879
THR C6891
GLY C6890
ASP C6906
GLN C6885
1.75A
SFG  C7103 ( 3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
THR A6908
THR A6880
ASP A6900
HIS B4333
ASN A6899
1.52A
None
None
None
None
SFG  A7103 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP16
(SARS-CoV-2)		5 / 12
THR C6915
LEU C7093
VAL A7086
GLY C6946
ASN A6920
1.66A
None
None
None
FMT  C7105 ( 2.9A)
FMT  A7109 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLY A6879
THR A6891
GLY A6890
ASP A6906
GLN A6885
1.73A
SFG  A7103 ( 3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP16
(SARS-CoV-2)		5 / 12
THR A6908
LEU A6893
GLY A6875
HIS A6867
ASN C7096
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP16
(SARS-CoV-2)		5 / 12
THR A6915
LEU A7093
VAL C7086
GLY A6946
ASN C6920
1.77A
None
None
None
None
FMT  C7106 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6876
THR A6889
GLY A6890
ASP A6895
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4323
VAL A6876
THR A6889
GLY A6890
ASP A6895
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
TRP A6886
PRO A6860
GLU B4313
PRO B4312
GLY B4303
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4323
VAL C6876
THR C6889
GLY C6890
ASP C6895
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
VAL B   6
TRP B  59
TRP B  87
THR B  84
1.75A16.80
None
TRS  B 402 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A 298
GLU A 203
ARG A 207
GLN A 160
PRO A 158
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
VAL A   6
TRP A  59
TRP A  87
THR A  84
1.75A16.80
None
TRS  A 402 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B 298
GLU B 203
ARG B 207
GLN B 160
PRO B 158
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.78A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.63A
U5G  A 401 (-3.0A)
U5G  A 401 ( 4.0A)
None
None
U5G  A 401 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
THR A 135
THR A 169
HIS A 163
ASN A 180
GLN A 192
1.42A
None
None
None
None
U5G  A 401 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY C  47
GLY C  46
HIS C  94
ASN C  54
PRO C  32
1.71A
APR  C 201 (-4.1A)
APR  C 201 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.71A
APR  A 201 (-3.1A)
APR  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.78A
None
None
APR  B 201 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY B  47
GLY B  46
HIS B  94
ASN B  54
PRO B  32
1.74A
APR  B 201 (-4.0A)
APR  B 201 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE D 132
SER D 128
SER D 139
VAL D  95
GLY D  79
1.77A
APR  D 201 (-3.5A)
APR  D 201 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.76A
APR  B 201 (-3.6A)
APR  B 201 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY D  79
LEU D  75
VAL D  41
ASP A 162
ASN D  40
1.70A
None
None
None
None
APR  D 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.74A
APR  B 201 (-3.6A)
APR  B 201 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.79A
None
None
APR  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR D 146
VAL D 142
SER D 128
VAL D  95
ALA D 112
1.78A
None
None
APR  D 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D 122
VAL D  34
THR D  13
ASN D 117
ASN A 159
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.79A
None
None
APR  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY B  79
LEU B  75
VAL B  41
ASP C 162
ASN B  40
1.67A
None
None
None
None
APR  B 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ASP A 145
ASP A 135
ASN A 101
1.78A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.77A
None
None
APR  B 201 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.75A
APR  C 201 (-3.5A)
APR  C 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.72A
APR  A 201 (-3.1A)
APR  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE D 132
SER D 128
SER D 139
VAL D  95
GLY D  79
1.77A
APR  D 201 (-3.5A)
APR  D 201 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.71A
APR  A 201 (-4.1A)
APR  A 201 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.74A
APR  B 201 (-3.6A)
APR  B 201 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.74A
APR  C 201 (-3.5A)
APR  C 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 122
VAL B  34
THR B  13
ASN B 117
ASN C 159
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY D  47
GLY D  46
HIS D  94
ASN D  54
PRO D  32
1.73A
APR  D 201 (-4.2A)
APR  D 201 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6879
THR A6891
GLY A6890
ASP A6906
GLN A6885
1.73A
SAH  A7101 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6842
THR B4364
ASP B4359
GLN B4351
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6876
THR A6889
GLY A6890
ASP A6895
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
TRP A6886
PRO A6860
GLU B4313
PRO B4312
GLY B4303
1.78A
None
None
SO4  B4403 ( 4.5A)
None
SO4  B4403 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
THR A 135
THR A 169
HIS A 163
ASN A 180
GLN A 192
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 146
LEU A  27
GLY A  15
ASN A 119
ASN A 142
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
ASP A 164
PHE A 173
VAL A 202
ASP A 302
PHE A 304
1.70A14.93
GOL  A 508 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR A 135
THR A 169
HIS A 163
ASN A 180
GLN A 192
1.47A18.86
None
None
O6K  A 402 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.58A13.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.77A13.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 10
VAL A  16
PHE B  92
SER A  57
GLY A  64
GLN B  88
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL B  68
PHE B  64
SER B  61
THR C 100
GLY B  35
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL H  68
PHE H  64
SER H  61
THR L 100
GLY H  35
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 10
THR H 169
VAL H 167
SER H 160
ASN H 203
VAL H 202
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE C 122
SER C 180
VAL B 186
GLY B 143
ALA B 141
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL A 341
PHE A 338
SER A 514
ASN A 394
VAL A 524
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU C  53
GLY B  44
GLU B  46
GLN C  95
PRO B 105
1.78A
None
1PE  C 301 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 395
PHE E 338
THR E 385
GLY E 526
ALA E 363
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU L  53
GLY H  44
GLU H  46
GLN L  95
PRO H 105
1.78A
None
1PE  L1603 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
ASP C  88
ASP C  66
ASN E 331
1.61A15.65
None
None
NAG  E 906 (-1.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
VAL E 367
PHE E 338
THR E 333
VAL E 362
GLY E 526
ALA E 363
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLY C 105
GLY C 107
GLY C  74
ASN C  22
PRO C   8
1.72A
None
1PE  C 301 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 395
PHE A 338
THR A 385
GLY A 526
ALA A 363
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 338
SER E 514
ASN E 394
VAL E 524
ALA E 363
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
THR L 212
VAL L 121
SER L 183
SER L 165
TRP L 154
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE C 122
SER C 180
VAL B 185
GLY B 143
ALA B 141
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
THR L 212
VAL L 121
SER L 183
SER L 165
ALA L 199
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL H  68
PHE H  64
SER H  61
THR L 100
GLY H  35
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE L 122
SER L 180
VAL H 185
GLY H 143
ALA H 141
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
VAL A 367
PHE A 338
THR A 333
VAL A 362
GLY A 526
ALA A 363
1.79A
NAG  A 904 (-4.5A)
None
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 401
SER A 443
THR A 500
ASN A 501
GLY A 504
1.74A
None
None
None
None
DMS  A 903 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 390
GLY B  99
ASP B 107
ASP A 389
ASN A 388
1.54A
DMS  A 905 (-4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
VAL E 367
PHE E 338
THR E 333
VAL E 362
GLY E 526
ALA E 363
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE L 122
SER L 180
VAL H 185
GLY H 143
ALA H 141
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 10
THR C  78
GLY C  70
LEU C  79
SER C  25
VAL C  64
1.68A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLY L 105
GLY L 107
GLY L  74
ASN L  22
PRO L   8
1.78A
None
1PE  L1603 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 395
PHE A 338
THR A 385
GLY A 526
ALA A 363
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR B 104
GLY B  99
ASP B 107
ASP A 389
ASN A 388
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 524
PHE E 392
THR E 385
VAL E 382
GLY E 431
1.79A
None
None
None
DMS  L1601 (-4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR H  31
GLY H  28
THR H 104
GLY E 381
ASN E 388
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR B   0
VAL B 108
SER B 100
ASN A 370
GLY L  63
1.79A
MLI  B 303 (-4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE L 122
SER L 180
VAL H 186
GLY H 143
ALA H 141
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 390
GLY H  99
ASP H 107
ASP E 389
ASN E 388
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 341
PHE A 338
SER A 514
ASN A 394
VAL A 524
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 341
PHE E 338
SER E 514
ASN E 394
VAL E 524
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL B  68
PHE B  64
SER B  61
THR C 100
GLY B  35
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE C 122
SER C 180
VAL B 185
GLY B 143
ALA B 141
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 341
PHE A 338
SER A 514
ASN A 394
VAL A 524
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL E 341
PHE E 338
SER E 514
ASN E 394
VAL E 524
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 401
SER A 443
THR A 500
ASN A 501
GLY A 504
1.73A
None
None
None
None
DMS  A 903 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
THR L 212
VAL L 121
SER L 183
SER L 165
TRP L 154
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE L 122
SER L 180
VAL H 185
GLY H 143
ALA H 141
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
VAL E 367
PHE E 338
THR E 333
VAL E 362
GLY E 526
ALA E 363
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
THR H 169
VAL H 167
SER H 160
ASN H 203
VAL H 202
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL L 169
PHE L 145
SER L 120
VAL L 202
ALA L 150
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 10
THR L  78
GLY L  70
LEU L  79
SER L  25
VAL L  64
1.80A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE L 122
SER L 180
VAL H 186
GLY H 143
ALA H 141
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 341
PHE E 338
SER E 514
ASN E 394
VAL E 524
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 338
SER E 514
ASN E 394
VAL E 524
ALA E 363
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL H  68
PHE H  64
SER H  61
THR L 100
GLY H  35
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL H  68
PHE H  64
SER H  61
THR L 100
GLY H  35
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
VAL E 367
PHE E 338
THR E 333
VAL E 362
GLY E 526
ALA E 363
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU L  53
GLY H  44
GLU H  46
GLN L  95
PRO H 105
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 390
GLY H  99
ASP H 107
ASP E 389
ASN E 388
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 10
THR H 169
VAL H 167
SER H 160
ASN H 203
VAL H 202
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 395
PHE E 338
THR E 385
GLY E 526
ALA E 363
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 338
SER E 514
ASN E 394
VAL E 524
ALA E 363
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 341
PHE E 338
SER E 514
ASN E 394
VAL E 524
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.64A
P6N  A 502 ( 4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 146
LEU A  27
GLY A  15
ASN A 119
ASN A 142
1.79A
None
None
None
None
P6N  A 502 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
PHE E 338
ASN E 334
VAL E 362
ALA E 363
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
PHE A 338
VAL A 362
GLY A 526
ALA A 363
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
THR L 212
VAL L 121
SER L 183
SER L 165
ALA L 199
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 10
THR B 169
VAL B 167
SER B 160
ASN B 203
VAL B 202
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
THR C 212
VAL C 121
SER C 183
SER C 165
ALA C 199
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL H  68
PHE H  64
SER H  61
THR L 100
GLY H  35
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL B  68
PHE B  64
SER B  61
THR C 100
GLY B  35
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
THR L 212
VAL L 121
SER L 183
SER L 165
TRP L 154
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ALA B 118
TYR E 489
GLN E 493
PHE E 490
GLY E 485
1.44A18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ALA H 118
TYR A 489
GLN A 493
PHE A 490
GLY A 485
1.42A18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
LEU L  53
GLY H  44
GLU H  46
GLN L  95
PRO H 105
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
PHE L 122
SER L 180
VAL H 186
GLY H 143
ALA H 141
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 395
PHE E 338
THR E 385
GLY E 526
ALA E 363
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR H  31
GLY H  28
THR H 104
GLY E 381
ASN E 388
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 10
THR H 169
VAL H 167
SER H 160
ASN H 203
VAL H 202
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR B  31
GLY B  28
THR B 104
GLY A 381
ASN A 388
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 524
PHE A 392
THR A 385
VAL A 382
GLY A 431
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 338
SER E 514
ASN E 394
VAL E 524
ALA E 363
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE A 338
SER A 514
ASN A 394
VAL A 524
ALA A 363
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL A 341
PHE A 338
SER A 514
ASN A 394
VAL A 524
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
PHE L 122
SER L 180
VAL H 185
GLY H 143
ALA H 141
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
GLY L 105
GLY L 107
GLY L  74
ASN L  22
PRO L   8
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL B  68
PHE B  64
SER B  61
THR C 100
GLY B  35
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
PHE C 122
SER C 180
VAL B 185
GLY B 143
ALA B 141
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
PHE A 338
ASN A 334
VAL A 362
ALA A 363
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
GLY C 105
GLY C 107
GLY C  74
ASN C  22
PRO C   8
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 390
GLY H  99
ASP H 107
ASP E 389
ASN E 388
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
PHE C 122
SER C 180
VAL B 185
GLY B 143
ALA B 141
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
PHE A 338
ASN A 334
VAL A 362
ALA A 363
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 341
PHE E 338
SER E 514
ASN E 394
VAL E 524
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 390
GLY B  99
ASP B 107
ASP A 389
ASN A 388
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 395
PHE A 338
THR A 385
GLY A 526
ALA A 363
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
PHE E 338
VAL E 362
GLY E 526
ALA E 363
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL H  68
PHE H  64
SER H  61
THR L 100
GLY H  35
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
PHE E 338
ASN E 334
VAL E 362
ALA E 363
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
LEU C  53
GLY B  44
GLU B  46
GLN C  95
PRO B 105
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
PHE C 122
SER C 180
VAL B 186
GLY B 143
ALA B 141
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
PHE E 338
VAL E 362
GLY E 526
ALA E 363
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL E 341
PHE E 338
SER E 514
ASN E 394
VAL E 524
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 524
PHE E 392
THR E 385
VAL E 382
GLY E 431
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
PHE L 122
SER L 180
VAL H 185
GLY H 143
ALA H 141
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
THR C 212
VAL C 121
SER C 183
SER C 165
TRP C 154
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
PHE A 338
VAL A 362
GLY A 526
ALA A 363
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 341
PHE A 338
SER A 514
ASN A 394
VAL A 524
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.79A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR A 135
THR A 169
HIS A 163
ASN A 180
GLN A 192
1.54A
None
None
DMS  A 403 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.75A
PK8  A 401 ( 4.0A)
PK8  A 401 ( 3.6A)
None
None
PK8  A 401 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE D 132
SER D 128
SER D 139
VAL D  95
GLY D  79
1.71A
EDO  D 205 ( 3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR E 146
VAL E 142
SER E 128
VAL E  95
ALA E 112
1.78A
None
None
EPE  E 202 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE D 132
SER D 128
SER D 139
VAL D  95
GLY D  79
1.69A
EDO  D 205 ( 3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE E 132
SER E 128
SER E 139
VAL E  95
GLY E  79
1.73A
EPE  E 202 (-3.2A)
EPE  E 202 (-4.6A)
None
None
EPE  E 203 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR C 146
VAL C 142
SER C 128
VAL C  95
ALA C 112
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D 165
THR D 149
TYR D 152
PRO D  32
GLY E   8
1.62A17.23
None
EDO  D 203 ( 4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  79
GLY A  78
GLY D  78
ASN D 117
PRO D  98
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR C 146
VAL C 142
SER C 128
VAL C  95
ALA C 112
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP C 145
ASP C 135
ASN C 101
1.70A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP B 145
ASP B 135
ASN B 101
1.76A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLU B  64
GLY B  85
LEU B  83
ASN B  37
PRO E 136
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY E  47
GLY E  46
HIS E  94
ASN E  54
PRO E  32
1.54A
EPE  E 202 (-4.3A)
EPE  E 202 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 165
THR E 149
TYR E 152
PRO E  32
GLY D   8
1.74A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  97
LEU D 127
VAL D 142
ASN D 115
GLN A 118
1.77A
None
None
None
EDO  D 201 (-3.6A)
EDO  D 201 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 126
LEU D 140
ALA D 129
ASP D 157
ASP D 162
1.79A
None
None
EDO  D 205 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  79
GLY D  78
GLY A  78
ASN A 117
PRO A  98
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  97
LEU A 127
VAL A 142
ASN A 115
GLN D 118
1.77A
EDO  A 202 ( 4.9A)
EDO  A 202 ( 4.8A)
None
EDO  D 201 (-3.4A)
EDO  D 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  47
GLY C  46
HIS C  94
ASN C  54
PRO C  32
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  47
GLY D  46
HIS D  94
ASN D  54
PRO D  32
1.55A
EDO  D 206 (-4.5A)
EDO  D 206 ( 4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  41
ASP E 145
ASP E 135
HIS E 138
GLY B  73
1.61A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  41
ASP E 145
ASP E 135
HIS E 138
GLY B  73
1.62A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE E 132
SER E 128
SER E 139
VAL E  95
GLY E  79
1.71A
EPE  E 202 (-3.2A)
EPE  E 202 (-4.6A)
None
None
EPE  E 203 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.56A
None
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B  47
GLY B  46
HIS B  94
ASN B  54
PRO B  32
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.57A
None
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
ASN B 115
VAL B  95
ALA B  39
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.60A
None
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR E 146
VAL E 142
SER E 128
VAL E  95
ALA E 112
1.77A
None
None
EPE  E 202 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.70A
EDO  A 202 (-3.9A)
EDO  A 202 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.77A
None
None
EDO  A 202 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.77A
None
None
EDO  A 202 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.72A
EDO  A 202 (-3.9A)
EDO  A 202 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR D 146
VAL D 142
SER D 128
VAL D  95
ALA D 112
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.73A
APR  B 201 (-3.5A)
APR  B 201 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR E 146
VAL E 142
SER E 128
VAL E  95
ALA E 112
1.78A
None
None
APR  E 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  47
GLY D  46
HIS D  94
ASN D  54
PRO D  32
1.73A
APR  D 201 ( 4.3A)
APR  D 201 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.72A
APR  A 201 (-3.7A)
APR  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR D 146
VAL D 142
SER D 128
VAL D  95
ALA D 112
1.79A
None
None
APR  D 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  47
GLY C  46
HIS C  94
ASN C  54
PRO C  32
1.69A
APR  C 201 (-4.3A)
APR  C 201 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR C 146
VAL C 142
SER C 128
VAL C  95
ALA C 112
1.80A
None
None
APR  C 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  97
LEU A 127
VAL A 142
ASN A 115
GLN D 118
1.78A
None
None
None
EDO  A 207 (-3.9A)
EDO  A 207 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLU B  64
GLY B  85
LEU B  83
ASN B  37
PRO E 136
1.29A
None
None
None
None
EDO  B 202 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE E 132
SER E 128
SER E 139
VAL E  95
GLY E  79
1.72A
APR  E 201 (-3.5A)
APR  E 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.72A
APR  A 201 (-3.7A)
APR  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE E 132
SER E 128
SER E 139
VAL E  95
GLY E  79
1.71A
APR  E 201 (-3.5A)
APR  E 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.72A
APR  C 201 (-3.5A)
APR  C 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B  97
LEU B 127
GLY E 133
ASN B  37
ASN B 115
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.74A
APR  B 201 (-3.5A)
APR  B 201 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR D 146
VAL D 142
SER D 128
VAL D  95
ALA D 112
1.79A
None
None
APR  D 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D 165
THR D 149
TYR D 152
PRO D  32
GLY E   8
1.66A17.23
None
None
None
None
EDO  E 203 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR E 146
VAL E 142
SER E 128
VAL E  95
ALA E 112
1.78A
None
None
APR  E 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.71A
APR  C 201 (-3.5A)
APR  C 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  41
ASP E 145
ASP E 135
HIS E 138
GLY B  73
1.58A16.18
None
None
EDO  B 202 (-4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE D 132
SER D 128
SER D 139
VAL D  95
GLY D  79
1.73A
APR  D 201 (-3.3A)
APR  D 201 (-4.3A)
None
None
EDO  D 203 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.78A
None
None
APR  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.60A
APR  A 201 (-4.1A)
APR  A 201 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE D 132
SER D 128
SER D 139
VAL D  95
GLY D  79
1.74A
APR  D 201 (-3.3A)
APR  D 201 (-4.3A)
None
None
EDO  D 203 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.78A
None
None
APR  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  79
GLY A  78
GLY D  78
ASN D 117
PRO D  98
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  41
ASP E 145
ASP E 135
HIS E 138
GLY B  73
1.59A16.18
None
None
EDO  B 202 (-4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  79
GLY D  78
GLY A  78
ASN A 117
PRO A  98
1.61A
EDO  D 203 (-3.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY E  47
GLY E  46
HIS E  94
ASN E  54
PRO E  32
1.71A
APR  E 201 (-4.4A)
APR  E 201 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.78A
None
None
APR  B 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  97
LEU D 127
VAL D 142
ASN D 115
GLN A 118
1.75A
None
None
None
EDO  A 207 ( 3.7A)
EDO  D 203 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 165
THR E 149
TYR E 152
PRO E  32
GLY D   8
1.74A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B  47
GLY B  46
HIS B  94
ASN B  54
PRO B  32
1.61A
APR  B 201 (-3.6A)
EDO  B 202 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.78A
None
None
APR  B 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  48
VAL D  24
ASP C  67
HIS C  86
ASN C  59
1.65A
EDO  D 204 ( 3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 126
LEU B 140
ALA B 129
ASP B 157
ASP B 162
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.78A
None
None
MES  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.72A
MES  A 201 (-3.5A)
MES  A 201 (-4.4A)
None
None
EDO  A 204 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.72A
MES  C 201 (-3.6A)
MES  C 201 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  97
LEU A 127
VAL A 142
ASN A 115
GLN C 118
1.74A
None
None
None
EDO  A 202 ( 3.5A)
EDO  A 204 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.53A
MES  A 201 ( 4.8A)
MES  A 201 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  97
LEU C 127
VAL C 142
ASN C 115
GLN A 118
1.78A
None
None
None
EDO  A 202 (-3.6A)
EDO  A 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  79
GLY C  78
GLY A  78
ASN A 117
PRO A  98
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  97
GLY C  73
HIS C  94
ASN C 115
GLN A 118
1.65A
None
None
None
EDO  A 202 (-3.6A)
EDO  A 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  47
GLY C  46
HIS C  94
ASN C  54
PRO C  32
1.53A
MES  C 201 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.71A
MES  A 201 (-3.5A)
MES  A 201 (-4.4A)
None
None
EDO  A 204 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP A 157
ASP B 145
ASN B 117
1.50A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR C 146
VAL C 142
SER C 128
VAL C  95
ALA C 112
1.78A
None
None
MES  C 201 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  79
GLY A  78
GLY C  78
ASN C 117
PRO C  98
1.59A
EDO  A 204 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.73A
MES  C 201 (-3.6A)
MES  C 201 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B  47
GLY B  46
HIS B  94
ASN B  54
PRO B  32
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR C 146
VAL C 142
SER C 128
VAL C  95
ALA C 112
1.79A
None
None
MES  C 201 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  79
LEU A 108
GLY A 130
ASP A 105
ASN C 117
1.79A
EDO  A 204 (-3.6A)
EDO  C 205 (-4.9A)
MES  A 201 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  97
GLY A  73
HIS A  94
ASN A 115
GLN C 118
1.62A
None
None
None
EDO  A 202 ( 3.5A)
EDO  A 204 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 126
LEU C 140
ALA C 129
ASP C 157
ASP C 162
1.77A
None
None
None
MG  C 202 ( 2.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.77A
None
None
MES  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.80A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		7btf NSP12
(SARS-CoV-2)		5 / 12
THR A 538
VAL A 398
THR A 565
ASP A 684
GLN A 541
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		7btf NSP12
(SARS-CoV-2)		5 / 10
THR A 680
GLY A 678
LEU A 663
PHE A 694
VAL A 315
1.66A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 652
SER A 649
ASN A 534
VAL A 535
ALA A 656
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 758
VAL A 588
GLY A 679
ASP A 623
ASN A 695
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7btf NSP12
(SARS-CoV-2)		5 / 12
GLN A 789
PHE A  45
ASP A  36
ASP A 465
HIS A 133
1.67A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
THR A 344
GLY A 345
VAL A 353
ASP B 112
ASN A 297
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7btf NSP12
(SARS-CoV-2)		5 / 12
THR A 710
ASN A 767
VAL A 776
GLY A 774
ALA A 706
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		7btf NSP12
(SARS-CoV-2)		5 / 12
THR A 148
LEU A 212
VAL A 182
ASP A 211
ASN A 213
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
LEU C  41
GLY A 413
ASP C  38
ASN C  37
GLN A 444
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7btf NSP12
(SARS-CoV-2)		5 / 12
THR A 710
ASN A 767
VAL A 776
GLY A 774
ALA A 706
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7btf NSP12
(SARS-CoV-2)		5 / 10
THR A 710
PHE A 745
ASN A 767
VAL A 776
GLY A 774
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASP A 390
ASP A 452
ASN A 552
1.58A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 652
SER A 649
ASN A 534
VAL A 535
ALA A 656
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7btf NSP12
(SARS-CoV-2)		5 / 12
GLN A 789
PHE A  45
ASP A  36
ASP A 465
HIS A 133
1.67A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.74A
JRY  A 401 (-3.3A)
None
None
None
JRY  A 401 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.79A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
THR A 687
THR A 538
VAL A 560
GLY A 683
ALA A 558
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
THR A 680
GLY A 678
LEU A 663
PHE A 694
VAL A 315
1.59A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 789
PHE A  45
ASP A  36
ASP A 465
HIS A 133
1.75A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
THR A 687
THR A 538
VAL A 560
GLY A 683
ALA A 558
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 789
PHE A  45
ASP A  36
ASP A 465
HIS A 133
1.80A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLY A 839
GLY A 841
LEU A 838
GLU A 811
ARG A 836
1.61A
None
None
None
None
U  P  18 ( 2.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
THR A 687
THR A 538
VAL A 560
GLY A 683
ALA A 558
1.77A
F86  P 102 (-3.6A)
None
U  T  10 ( 4.6A)
U  T  10 ( 3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
THR A 687
THR A 538
VAL A 560
GLY A 683
ALA A 558
1.75A
F86  P 102 (-3.6A)
None
U  T  10 ( 4.6A)
U  T  10 ( 3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
THR A 344
GLY A 345
VAL A 353
ASP B 112
ASN A 297
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
THR A 680
GLY A 678
LEU A 663
PHE A 694
VAL A 315
1.69A20.70
F86  P 102 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLN A 789
PHE A  45
ASP A  36
ASP A 465
HIS A 133
1.77A21.65
None