Ligand ID: QPS


Drugbank ID:
DB00284
(Acarbose)


Indication:
For treatment and management of diabetes type II (used in combination therapy as a second or third line agent)

Get human targets for QPS in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'QPS' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		5r7z 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.76A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.77A13.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.56A13.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6lu7 MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 261
ASP A 197
ASN A 203
GLN A 110
PRO A 293
1.80A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 10
THR F 941
GLY F 946
LEU F 945
SER E 939
VAL F 952
1.57A13.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		3 / 3
ASP D 950
ASP D1184
ASN D1192
0.92A10.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.77A19.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.62A19.09
ELL  D   3 (-3.6A)
None
None
None
ALC  D   2 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.67A19.66
ELL  D   3 (-3.6A)
None
None
None
N0A  D   2 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.78A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		5 / 12
VAL E 510
ASN E 439
GLN E 506
PRO E 507
GLY E 404
1.73A18.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		5 / 12
VAL E 510
ASN E 439
GLN E 506
PRO E 507
GLY E 404
1.72A18.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY C 146
LEU C  27
GLY C  15
ASN C 119
ASN C 142
1.75A18.86
None
None
None
None
3WL  C 401 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C 114
PHE C 150
SER C  10
VAL A 125
ALA C   7
1.77A15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY D 143
LEU D  27
VAL D  20
GLY D 170
HIS D  41
1.62A18.86
3WL  D 401 (-3.4A)
None
None
None
3WL  D 401 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY B 143
LEU B  27
VAL B  20
GLY B 170
HIS B  41
1.73A18.86
3WL  B 401 (-3.4A)
None
None
None
3WL  B 401 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY C 143
LEU C  27
VAL C  20
GLY C 170
HIS C  41
1.65A18.86
3WL  C 401 (-3.4A)
None
None
None
3WL  C 401 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
THR B 135
THR B 169
HIS B 163
ASN B 180
GLN B 192
1.49A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
THR A 135
THR A 169
HIS A 163
ASN A 180
GLN A 192
1.50A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.71A18.86
3WL  A 401 (-3.3A)
None
None
None
3WL  A 401 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 146
LEU A  27
GLY A  15
ASN A 119
ASN A 142
1.77A18.86
None
None
None
None
3WL  A 401 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL D 114
PHE D 150
SER D  10
VAL B 125
ALA D   7
1.78A15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B 157
TYR B 182
TYR B 161
VAL B  13
CYH B  16
1.80A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY B 146
LEU B  27
GLY B  15
ASN B 119
ASN B 142
1.77A18.86
None
None
None
None
3WL  B 401 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.79A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.68A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ASP C 104
ASP C  64
ASN C 127
1.12A12.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
THR A 136
VAL A  73
ASN A 141
GLY A 138
GLN A  84
1.78A8.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
THR C 136
VAL C  73
ASN C 141
GLY C 138
GLN C  84
1.67A8.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m71 NSP12
(SARS-CoV-2)		5 / 12
THR A 148
LEU A 212
VAL A 182
ASP A 211
ASN A 213
1.79A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		6m71 NSP12
(SARS-CoV-2)		5 / 10
THR A 680
GLY A 678
LEU A 663
PHE A 694
VAL A 315
1.50A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m71 NSP12
NSP7
(SARS-CoV-2)		5 / 12
VAL A 424
PHE A 429
SER C   4
THR C  45
GLY A 432
1.77A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 758
VAL A 588
THR A 680
ASP A 761
ASN A 695
1.80A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 758
VAL A 588
GLY A 679
ASP A 623
ASN A 695
1.71A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
THR A 710
PHE A 745
ASN A 767
VAL A 776
GLY A 774
1.77A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
THR A 710
PHE A 745
ASN A 767
VAL A 776
GLY A 774
1.75A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 387
TYR B 149
LEU B 122
ALA A 399
ASP A 390
1.76A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6m71 NSP12
(SARS-CoV-2)		5 / 12
GLY A 179
LEU A 178
ASP A 170
ASN A 150
ASN A 213
1.61A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6m71 NSP12
(SARS-CoV-2)		5 / 10
THR A 710
PHE A 745
ASN A 767
VAL A 776
GLY A 774
1.73A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL B1068
HIS B1064
GLU C1031
GLN C 784
GLY C 889
1.77A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP B1139
LEU B1141
GLN B1142
ASP C1139
ASP C1118
1.75A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL B 130
PHE B 168
SER A 359
THR A 393
GLY B 199
1.39A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY A 889
LEU A1034
VAL A 785
GLY A 908
GLN A 901
1.51A18.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
THR C 778
GLY C1059
HIS C1058
VAL C 952
GLU C 773
1.64A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
VAL A   6
TRP A  59
TRP A  87
THR A  84
1.79A16.78
None
GOL  A 401 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A 298
GLU A 203
ARG A 207
GLN A 160
PRO A 158
1.43A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY B  47
GLY B  46
HIS B  94
ASN B  54
PRO B  32
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY B  51
LEU B  53
VAL B  24
THR A  71
HIS B  94
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 10
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 10
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.57A
None
None
None
None
SO4  A 201 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
THR A  71
SER B  65
ASN B  59
GLY B  46
ALA B  50
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
THR A  71
SER B  65
ASN B  59
GLY B  46
ALA B  50
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
ASN B 115
VAL B  95
ALA B  39
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B  53
VAL B  35
THR A  71
ASN B  54
GLN B  62
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.54A
None
None
None
None
SO4  A 201 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 10
THR A  71
SER B  65
ASN B  59
GLY B  46
ALA B  50
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.58A
None
None
None
None
SO4  A 201 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP A 775
ASP A 867
ASN A 824
1.12A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP A1139
LEU A1141
GLN A1142
ASP C1118
ASP A1118
1.61A22.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP A1139
LEU A1141
GLN A1142
ASP C1118
ASP A1118
1.58A22.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY A 889
LEU A1034
VAL A 785
GLY A 908
GLN A 901
1.46A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE C1095
SER C1097
THR C1076
ASN C 710
GLY C1131
1.55A22.09
None
None
None
None
NAG  C1311 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP B 405
ASN C 439
ASN C 448
PRO C 499
GLY C 496
1.73A18.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
PHE C1095
SER C1097
ASN C 710
GLY C1131
ALA C1080
1.70A22.09
None
None
None
NAG  C1311 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP C1139
LEU C1141
GLN C1142
ASP B1118
ASP C1118
1.43A22.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL C 576
PHE C 565
ASN A 978
GLY C 545
GLN C 564
1.71A22.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A1040
THR A1105
TYR B 904
PRO A1079
GLY B 891
1.70A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
PHE A 592
SER A 591
ASN A 616
VAL A 615
GLY A 648
1.80A22.11
None
None
NAG  A1309 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 889
LEU C1034
VAL C 785
GLY C 908
GLN C 901
1.48A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL B 610
THR B 618
ASN B 616
VAL B 615
GLY B 648
1.49A22.11
None
NAG  B1308 (-3.5A)
NAG  B1308 (-2.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP A 364
ASP A 389
ASN A 540
0.89A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP C1139
LEU C1141
GLN C1142
ASP B1118
ASP C1118
1.42A22.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
THR A 778
GLY A1059
HIS A1058
VAL A 952
GLU A 773
1.62A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 10
THR D 135
VAL D  72
ASN D 140
GLY D 137
GLN D  83
1.76A8.68
None
None
None
None
GOL  D 204 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		3 / 3
ASP D 103
ASP D  63
ASN D 126
1.01A11.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w02 NSP3
(SARS-CoV-2)		5 / 12
LEU B 126
LEU B 140
ALA B 129
ASP B 157
ASP B 162
1.77A14.33
APR  B 201 (-4.8A)
None
APR  B 201 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
VAL C 401
SER C 443
THR C 500
ASN C 501
GLY C 504
1.78A10.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU C 390
GLY H  95
ASP H 101
ASP C 389
ASN C 388
1.77A15.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6w4h NSP10
NSP16
(SARS-CoV-2)		5 / 12
TRP A6886
PRO A6860
GLU B4313
PRO B4312
GLY B4303
1.77A18.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6876
THR A6889
GLY A6890
ASP A6895
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
TRP A6886
PRO A6860
GLU B4313
PRO B4312
GLY B4303
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6w61 NSP10
(SARS-CoV-2)		5 / 12
GLY B4322
GLY B4323
LEU B4345
GLY B4303
PRO B4360
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6879
THR A6891
GLY A6890
ASP A6906
GLN A6885
1.77A
SAM  A7104 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4323
GLY B4347
GLY A6837
PRO A6835
GLN B4351
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.73A
X77  A 401 (-3.6A)
X77  A 401 ( 3.9A)
None
None
X77  A 401 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 10
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.57A
AMP  A 201 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.78A
None
None
MES  B 201 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
ASN A 115
VAL A  95
ALA A  39
1.76A
AMP  A 201 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
ALA A  39
1.78A
AMP  A 201 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.78A
None
None
MES  B 201 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.72A
MES  B 201 ( 3.4A)
MES  B 201 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 10
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.73A
MES  B 201 ( 3.4A)
MES  B 201 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
ALA A  39
1.80A
AMP  A 201 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.73A
MES  B 201 ( 3.4A)
MES  B 201 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.57A
AMP  A 201 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY B  47
GLY B  46
HIS B  94
ASN B  54
PRO B  32
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 126
LEU B 140
ALA B 129
ASP B 157
ASP B 162
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.61A
AMP  A 201 ( 4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP16
(SARS-CoV-2)		5 / 12
THR A6915
LEU A7093
VAL C7086
GLY A6946
ASN C6920
1.78A12.77
None
None
None
FMT  A7108 ( 4.8A)
FMT  C7106 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP16
(SARS-CoV-2)		5 / 12
THR C6915
LEU C7093
VAL A7086
GLY C6946
ASN A6920
1.66A12.77
None
None
None
FMT  C7115 ( 3.0A)
FMT  A7106 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4322
VAL C6876
THR C6889
GLY C6890
ASP C6895
1.47A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6876
THR A6889
GLY A6890
ASP A6895
1.54A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6879
THR C6891
GLY C6890
ASP C6906
GLN C6885
1.78A12.77
SAM  C7105 ( 3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4323
VAL C6876
THR C6889
GLY C6890
ASP C6895
1.75A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
TRP C6886
PRO C6860
GLU D4313
PRO D4312
GLY D4303
1.74A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w75 NSP10
(SARS-CoV-2)		5 / 12
THR B4364
VAL B4350
SER B4325
THR B4292
GLY B4362
1.72A9.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4323
GLY B4347
GLY A6837
PRO A6835
GLN B4351
1.76A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4323
GLY D4347
GLY C6837
PRO C6835
GLN D4351
1.77A12.42
None
None
FMT  D4404 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
TRP A6886
PRO A6860
GLU B4313
PRO B4312
GLY B4303
1.77A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP16
(SARS-CoV-2)		5 / 12
THR C6908
LEU C6893
GLY C6875
HIS C6867
ASN A7096
1.44A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6879
THR A6891
GLY A6890
ASP A6906
GLN A6885
1.76A12.77
SAM  A7102 ( 3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
THR A6908
THR A6880
ASP A6900
HIS B4333
ASN A6899
1.62A12.77
None
None
None
None
SAM  A7102 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6879
VAL C6876
THR C6891
GLY C6890
GLN C6885
1.76A12.77
SAM  C7105 ( 3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASP B 164
PHE B 173
VAL B 202
ASP B 302
PHE B 304
1.64A15.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  80
TYR A  56
ALA A  68
GLU A  67
HIS A  17
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  64
VAL A  66
THR A  42
ASP A  61
ASN A  60
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B  80
LEU B  58
ALA B  68
GLU B  67
HIS B  17
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A  56
LEU A  80
ALA A  68
GLU A  67
HIS A  17
1.60A19.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C  64
VAL C  66
THR C  42
GLY C  28
ASP C  61
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B 150
TYR B  83
ALA B 135
GLU B 143
ASP B  37
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C  80
LEU C  58
ALA C  68
GLU C  67
HIS C  17
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLU B 167
GLY B 163
TYR B 171
PRO B 129
GLY B 160
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLY B 163
GLY A 271
HIS B 272
ASN B 110
PRO A 248
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C  87
TYR C  83
ALA C 145
GLU C 143
ASP C 134
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
ASP B  61
ASP B  12
ASN B 146
1.51A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
THR A 265
GLY A 266
ASP A 286
ASN C 267
ASN A 109
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B  80
TYR B  56
ALA B  68
GLU B  67
HIS B  17
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  80
LEU A  58
ALA A  68
GLU A  67
HIS A  17
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASP A 164
PHE A 173
VAL A 202
ASP A 302
PHE A 304
1.66A15.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASP C 164
PHE C 173
VAL C 202
ASP C 302
PHE C 304
1.62A15.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
ASP A  61
ASP A  12
ASN A 146
1.60A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 150
TYR A  83
ALA A 135
GLU A 143
ASP A  37
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 150
TYR A  83
ASP A 134
ALA A 135
GLU A 143
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C 150
TYR C  83
ALA C 135
GLU C 143
ASP C  37
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.73A
MES  A 201 (-2.5A)
MES  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.74A
MES  A 201 (-2.5A)
MES  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.78A
None
None
MES  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wcf NSP3
(SARS-CoV-2)		5 / 10
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.75A
MES  A 201 (-2.5A)
MES  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.78A
None
None
MES  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wcf NSP3
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.57A
MES  A 202 (-3.4A)
MES  A 202 (-4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 10
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A  48
GLY A  47
HIS A  94
ASN A  54
PRO A  32
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
ASN A 115
VAL A  95
ALA A  39
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
ASN A 115
VAL A  95
ALA A  39
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 126
LEU A 140
ALA A 129
ASP A 157
ASP A 162
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
ALA A  39
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wey NSP3
(SARS-CoV-2)		5 / 10
PHE A 336
SER A 332
SER A 343
VAL A 299
GLY A 283
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wey NSP3
(SARS-CoV-2)		5 / 12
THR A 350
VAL A 346
SER A 332
VAL A 299
ALA A 316
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wey NSP3
(SARS-CoV-2)		5 / 12
GLY A 251
GLY A 250
HIS A 298
ASN A 258
PRO A 236
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wey NSP3
(SARS-CoV-2)		5 / 12
PHE A 336
SER A 332
SER A 343
VAL A 299
GLY A 283
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wey NSP3
(SARS-CoV-2)		5 / 12
THR A 350
VAL A 346
SER A 332
VAL A 299
ALA A 316
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wey NSP3
(SARS-CoV-2)		5 / 12
PHE A 336
SER A 332
SER A 343
VAL A 299
GLY A 283
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS B 300
TYR B 298
PHE B 363
HIS B 356
ASP B 288
1.71A10.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR F 332
GLY F 321
THR F 325
GLY F 328
ASN E 354
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS D 300
TYR D 298
PHE D 363
HIS D 356
ASP D 288
1.79A10.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS E 300
TYR E 298
PHE E 363
HIS E 356
ASP E 288
1.78A10.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR A 332
GLY A 321
THR A 325
GLY A 328
ASN B 354
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR B 332
GLY B 321
THR B 325
GLY B 328
ASN A 354
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS A 300
TYR A 298
PHE A 363
HIS A 356
ASP A 288
1.70A10.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY A 321
LEU B 353
THR A 325
ASP B 341
ASN B 354
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS C 300
TYR C 298
PHE C 363
HIS C 356
ASP C 288
1.70A10.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY C 321
LEU D 353
THR C 325
ASP D 341
ASN D 354
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR C 332
GLY C 321
THR C 325
GLY C 328
ASN D 354
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
THR C6908
LEU C6893
GLY C6875
HIS C6867
ASN A7096
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4323
GLY B4347
GLY A6837
PRO A6835
GLN B4351
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY C6879
THR C6891
GLY C6890
ASP C6906
GLN C6885
1.76A
SAH  C7102 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY D4323
VAL C6876
THR C6889
GLY C6890
ASP C6895
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
TRP C6886
PRO C6860
GLU D4313
PRO D4312
GLY D4303
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
THR A6908
LEU A6893
GLY A6875
HIS A6867
ASN C7096
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY C6879
VAL C6876
THR C6891
GLY C6890
GLN C6885
1.79A
SAH  C7102 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
THR A6908
THR A6880
ASP A6900
HIS B4333
ASN A6899
1.46A
None
None
None
None
SAH  A7102 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
THR C6915
LEU C7093
VAL A7086
GLY C6946
ASN A6920
1.64A
FMT  C7107 (-3.7A)
None
None
None
FMT  A7106 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
THR A6908
THR A6880
GLY A6879
ASP A6900
ASN A6899
1.51A
None
None
SAH  A7102 (-3.5A)
None
SAH  A7102 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6876
THR A6889
GLY A6890
ASP A6895
1.55A
None
None
NA  A7101 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
TRP A6886
PRO A6860
GLU B4313
PRO B4312
GLY B4303
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY A6875
GLY D4341
ASP A6897
ASN A6899
ASN A6841
1.77A
None
None
SAH  A7102 (-2.6A)
SAH  A7102 (-4.0A)
SAH  A7102 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY D4322
VAL C6876
THR C6889
GLY C6890
ASP C6895
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6879
THR A6891
GLY A6890
ASP A6906
GLN A6885
1.75A
SAH  A7102 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR D 115
GLY D 147
THR D 141
ASN D  75
ASN D 154
1.73A
None
None
None
MES  D 201 (-3.0A)
MES  D 201 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLU D  62
GLY D  60
GLY D  71
PRO D 162
PRO A  80
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR B 135
VAL B  72
ASN B 140
GLY B 137
GLN B  83
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU D 121
THR D 148
GLY D 147
ASP D 144
ASN D 126
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR A 141
LEU A 139
THR A 115
GLY A 147
HIS D  59
1.63A
None
None
None
None
ZN  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU C 121
THR C 148
GLY C 147
ASP C 144
ASN C 126
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
THR C 135
VAL C  72
ASN C 140
GLY C 137
GLN C  83
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ASP B 103
ASP B  63
ASN B 126
1.30A11.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR A 135
VAL A  72
ASN A 140
GLY A 137
GLN A  83
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
THR B 135
VAL B  72
ASN B 140
GLY B 137
GLN B  83
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR C 135
VAL C  72
ASN C 140
GLY C 137
GLN C  83
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR B 115
GLY B 147
THR B 141
ASN B  75
ASN B 154
1.69A
None
None
None
MES  B 201 (-3.1A)
MES  B 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
THR A 135
VAL A  72
ASN A 140
GLY A 137
GLN A  83
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
TRP C6886
PRO C6860
GLU D4313
PRO D4312
GLY D4303
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4323
GLY D4347
GLY C6837
PRO C6835
GLN D4351
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLY C6879
VAL C6876
THR C6891
GLY C6890
GLN C6885
1.77A
SFG  C7103 ( 3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4322
VAL C6876
THR C6889
GLY C6890
ASP C6895
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4323
GLY B4347
GLY A6837
PRO A6835
GLN B4351
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP16
(SARS-CoV-2)		5 / 12
THR C6908
LEU C6893
GLY C6875
HIS C6867
ASN A7096
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLY C6879
THR C6891
GLY C6890
ASP C6906
GLN C6885
1.75A
SFG  C7103 ( 3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
THR A6908
THR A6880
ASP A6900
HIS B4333
ASN A6899
1.52A
None
None
None
None
SFG  A7103 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP16
(SARS-CoV-2)		5 / 12
THR C6915
LEU C7093
VAL A7086
GLY C6946
ASN A6920
1.66A
None
None
None
FMT  C7105 ( 2.9A)
FMT  A7109 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLY A6879
THR A6891
GLY A6890
ASP A6906
GLN A6885
1.73A
SFG  A7103 ( 3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP16
(SARS-CoV-2)		5 / 12
THR A6908
LEU A6893
GLY A6875
HIS A6867
ASN C7096
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP16
(SARS-CoV-2)		5 / 12
THR A6915
LEU A7093
VAL C7086
GLY A6946
ASN C6920
1.77A
None
None
None
None
FMT  C7106 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6876
THR A6889
GLY A6890
ASP A6895
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4323
VAL A6876
THR A6889
GLY A6890
ASP A6895
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
TRP A6886
PRO A6860
GLU B4313
PRO B4312
GLY B4303
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4323
VAL C6876
THR C6889
GLY C6890
ASP C6895
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
VAL B   6
TRP B  59
TRP B  87
THR B  84
1.75A16.80
None
TRS  B 402 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A 298
GLU A 203
ARG A 207
GLN A 160
PRO A 158
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
VAL A   6
TRP A  59
TRP A  87
THR A  84
1.75A16.80
None
TRS  A 402 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B 298
GLU B 203
ARG B 207
GLN B 160
PRO B 158
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.78A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.63A
U5G  A 401 (-3.0A)
U5G  A 401 ( 4.0A)
None
None
U5G  A 401 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
THR A 135
THR A 169
HIS A 163
ASN A 180
GLN A 192
1.42A
None
None
None
None
U5G  A 401 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY C  47
GLY C  46
HIS C  94
ASN C  54
PRO C  32
1.71A
APR  C 201 (-4.1A)
APR  C 201 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.71A
APR  A 201 (-3.1A)
APR  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.78A
None
None
APR  B 201 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY B  47
GLY B  46
HIS B  94
ASN B  54
PRO B  32
1.74A
APR  B 201 (-4.0A)
APR  B 201 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE D 132
SER D 128
SER D 139
VAL D  95
GLY D  79
1.77A
APR  D 201 (-3.5A)
APR  D 201 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.76A
APR  B 201 (-3.6A)
APR  B 201 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY D  79
LEU D  75
VAL D  41
ASP A 162
ASN D  40
1.70A
None
None
None
None
APR  D 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.74A
APR  B 201 (-3.6A)
APR  B 201 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.79A
None
None
APR  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR D 146
VAL D 142
SER D 128
VAL D  95
ALA D 112
1.78A
None
None
APR  D 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D 122
VAL D  34
THR D  13
ASN D 117
ASN A 159
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.79A
None
None
APR  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY B  79
LEU B  75
VAL B  41
ASP C 162
ASN B  40
1.67A
None
None
None
None
APR  B 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ASP A 145
ASP A 135
ASN A 101
1.78A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.77A
None
None
APR  B 201 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.75A
APR  C 201 (-3.5A)
APR  C 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.72A
APR  A 201 (-3.1A)
APR  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE D 132
SER D 128
SER D 139
VAL D  95
GLY D  79
1.77A
APR  D 201 (-3.5A)
APR  D 201 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.71A
APR  A 201 (-4.1A)
APR  A 201 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.74A
APR  B 201 (-3.6A)
APR  B 201 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.74A
APR  C 201 (-3.5A)
APR  C 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 122
VAL B  34
THR B  13
ASN B 117
ASN C 159
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY D  47
GLY D  46
HIS D  94
ASN D  54
PRO D  32
1.73A
APR  D 201 (-4.2A)
APR  D 201 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6879
THR A6891
GLY A6890
ASP A6906
GLN A6885
1.73A
SAH  A7101 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6842
THR B4364
ASP B4359
GLN B4351
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6876
THR A6889
GLY A6890
ASP A6895
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
TRP A6886
PRO A6860
GLU B4313
PRO B4312
GLY B4303
1.78A
None
None
SO4  B4403 ( 4.5A)
None
SO4  B4403 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
THR A 135
THR A 169
HIS A 163
ASN A 180
GLN A 192
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 146
LEU A  27
GLY A  15
ASN A 119
ASN A 142
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
ASP A 164
PHE A 173
VAL A 202
ASP A 302
PHE A 304
1.70A14.93
GOL  A 508 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR A 135
THR A 169
HIS A 163
ASN A 180
GLN A 192
1.47A18.86
None
None
O6K  A 402 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.58A13.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.77A13.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 10
VAL A  16
PHE B  92
SER A  57
GLY A  64
GLN B  88
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL A 341
PHE A 338
SER A 514
ASN A 394
VAL A 524
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 395
PHE E 338
THR E 385
GLY E 526
ALA E 363
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
ASP C  88
ASP C  66
ASN E 331
1.61A15.65
None
None
NAG  E 906 (-1.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
VAL E 367
PHE E 338
THR E 333
VAL E 362
GLY E 526
ALA E 363
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 395
PHE A 338
THR A 385
GLY A 526
ALA A 363
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 338
SER E 514
ASN E 394
VAL E 524
ALA E 363
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
VAL A 367
PHE A 338
THR A 333
VAL A 362
GLY A 526
ALA A 363
1.79A
NAG  A 904 (-4.5A)
None
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 401
SER A 443
THR A 500
ASN A 501
GLY A 504
1.74A
None
None
None
None
DMS  A 903 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 390
GLY B  99
ASP B 107
ASP A 389
ASN A 388
1.54A
DMS  A 905 (-4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
VAL E 367
PHE E 338
THR E 333
VAL E 362
GLY E 526
ALA E 363
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 395
PHE A 338
THR A 385
GLY A 526
ALA A 363
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR B 104
GLY B  99
ASP B 107
ASP A 389
ASN A 388
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 524
PHE E 392
THR E 385
VAL E 382
GLY E 431
1.79A
None
None
None
DMS  L1601 (-4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR H  31
GLY H  28
THR H 104
GLY E 381
ASN E 388
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR B   0
VAL B 108
SER B 100
ASN A 370
GLY L  63
1.79A
MLI  B 303 (-4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 390
GLY H  99
ASP H 107
ASP E 389
ASN E 388
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 341
PHE A 338
SER A 514
ASN A 394
VAL A 524
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 341
PHE E 338
SER E 514
ASN E 394
VAL E 524
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 341
PHE A 338
SER A 514
ASN A 394
VAL A 524
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL E 341
PHE E 338
SER E 514
ASN E 394
VAL E 524
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 401
SER A 443
THR A 500
ASN A 501
GLY A 504
1.73A
None
None
None
None
DMS  A 903 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
VAL E 367
PHE E 338
THR E 333
VAL E 362
GLY E 526
ALA E 363
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 341
PHE E 338
SER E 514
ASN E 394
VAL E 524
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 338
SER E 514
ASN E 394
VAL E 524
ALA E 363
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
VAL E 367
PHE E 338
THR E 333
VAL E 362
GLY E 526
ALA E 363
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 390
GLY H  99
ASP H 107
ASP E 389
ASN E 388
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 395
PHE E 338
THR E 385
GLY E 526
ALA E 363
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 338
SER E 514
ASN E 394
VAL E 524
ALA E 363
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 341
PHE E 338
SER E 514
ASN E 394
VAL E 524
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.64A
P6N  A 502 ( 4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 146
LEU A  27
GLY A  15
ASN A 119
ASN A 142
1.79A
None
None
None
None
P6N  A 502 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
PHE E 338
ASN E 334
VAL E 362
ALA E 363
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
PHE A 338
VAL A 362
GLY A 526
ALA A 363
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ALA B 118
TYR E 489
GLN E 493
PHE E 490
GLY E 485
1.44A18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ALA H 118
TYR A 489
GLN A 493
PHE A 490
GLY A 485
1.42A18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 395
PHE E 338
THR E 385
GLY E 526
ALA E 363
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR H  31
GLY H  28
THR H 104
GLY E 381
ASN E 388
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR B  31
GLY B  28
THR B 104
GLY A 381
ASN A 388
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 524
PHE A 392
THR A 385
VAL A 382
GLY A 431
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 338
SER E 514
ASN E 394
VAL E 524
ALA E 363
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE A 338
SER A 514
ASN A 394
VAL A 524
ALA A 363
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL A 341
PHE A 338
SER A 514
ASN A 394
VAL A 524
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
PHE A 338
ASN A 334
VAL A 362
ALA A 363
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 390
GLY H  99
ASP H 107
ASP E 389
ASN E 388
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
PHE A 338
ASN A 334
VAL A 362
ALA A 363
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 341
PHE E 338
SER E 514
ASN E 394
VAL E 524
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 390
GLY B  99
ASP B 107
ASP A 389
ASN A 388
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 395
PHE A 338
THR A 385
GLY A 526
ALA A 363
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
PHE E 338
VAL E 362
GLY E 526
ALA E 363
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
PHE E 338
ASN E 334
VAL E 362
ALA E 363
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
PHE E 338
VAL E 362
GLY E 526
ALA E 363
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL E 341
PHE E 338
SER E 514
ASN E 394
VAL E 524
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 524
PHE E 392
THR E 385
VAL E 382
GLY E 431
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
PHE A 338
VAL A 362
GLY A 526
ALA A 363
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 341
PHE A 338
SER A 514
ASN A 394
VAL A 524
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.79A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR A 135
THR A 169
HIS A 163
ASN A 180
GLN A 192
1.54A
None
None
DMS  A 403 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.75A
PK8  A 401 ( 4.0A)
PK8  A 401 ( 3.6A)
None
None
PK8  A 401 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE D 132
SER D 128
SER D 139
VAL D  95
GLY D  79
1.71A
EDO  D 205 ( 3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR E 146
VAL E 142
SER E 128
VAL E  95
ALA E 112
1.78A
None
None
EPE  E 202 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE D 132
SER D 128
SER D 139
VAL D  95
GLY D  79
1.69A
EDO  D 205 ( 3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE E 132
SER E 128
SER E 139
VAL E  95
GLY E  79
1.73A
EPE  E 202 (-3.2A)
EPE  E 202 (-4.6A)
None
None
EPE  E 203 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR C 146
VAL C 142
SER C 128
VAL C  95
ALA C 112
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D 165
THR D 149
TYR D 152
PRO D  32
GLY E   8
1.62A17.23
None
EDO  D 203 ( 4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  79
GLY A  78
GLY D  78
ASN D 117
PRO D  98
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR C 146
VAL C 142
SER C 128
VAL C  95
ALA C 112
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP C 145
ASP C 135
ASN C 101
1.70A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP B 145
ASP B 135
ASN B 101
1.76A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLU B  64
GLY B  85
LEU B  83
ASN B  37
PRO E 136
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY E  47
GLY E  46
HIS E  94
ASN E  54
PRO E  32
1.54A
EPE  E 202 (-4.3A)
EPE  E 202 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 165
THR E 149
TYR E 152
PRO E  32
GLY D   8
1.74A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  97
LEU D 127
VAL D 142
ASN D 115
GLN A 118
1.77A
None
None
None
EDO  D 201 (-3.6A)
EDO  D 201 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 126
LEU D 140
ALA D 129
ASP D 157
ASP D 162
1.79A
None
None
EDO  D 205 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  79
GLY D  78
GLY A  78
ASN A 117
PRO A  98
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  97
LEU A 127
VAL A 142
ASN A 115
GLN D 118
1.77A
EDO  A 202 ( 4.9A)
EDO  A 202 ( 4.8A)
None
EDO  D 201 (-3.4A)
EDO  D 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  47
GLY C  46
HIS C  94
ASN C  54
PRO C  32
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  47
GLY D  46
HIS D  94
ASN D  54
PRO D  32
1.55A
EDO  D 206 (-4.5A)
EDO  D 206 ( 4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  41
ASP E 145
ASP E 135
HIS E 138
GLY B  73
1.61A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  41
ASP E 145
ASP E 135
HIS E 138
GLY B  73
1.62A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE E 132
SER E 128
SER E 139
VAL E  95
GLY E  79
1.71A
EPE  E 202 (-3.2A)
EPE  E 202 (-4.6A)
None
None
EPE  E 203 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.56A
None
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B  47
GLY B  46
HIS B  94
ASN B  54
PRO B  32
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.57A
None
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
ASN B 115
VAL B  95
ALA B  39
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.60A
None
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR E 146
VAL E 142
SER E 128
VAL E  95
ALA E 112
1.77A
None
None
EPE  E 202 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.70A
EDO  A 202 (-3.9A)
EDO  A 202 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.77A
None
None
EDO  A 202 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.77A
None
None
EDO  A 202 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.72A
EDO  A 202 (-3.9A)
EDO  A 202 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR D 146
VAL D 142
SER D 128
VAL D  95
ALA D 112
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.73A
APR  B 201 (-3.5A)
APR  B 201 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR E 146
VAL E 142
SER E 128
VAL E  95
ALA E 112
1.78A
None
None
APR  E 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  47
GLY D  46
HIS D  94
ASN D  54
PRO D  32
1.73A
APR  D 201 ( 4.3A)
APR  D 201 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.72A
APR  A 201 (-3.7A)
APR  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR D 146
VAL D 142
SER D 128
VAL D  95
ALA D 112
1.79A
None
None
APR  D 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  47
GLY C  46
HIS C  94
ASN C  54
PRO C  32
1.69A
APR  C 201 (-4.3A)
APR  C 201 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR C 146
VAL C 142
SER C 128
VAL C  95
ALA C 112
1.80A
None
None
APR  C 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  97
LEU A 127
VAL A 142
ASN A 115
GLN D 118
1.78A
None
None
None
EDO  A 207 (-3.9A)
EDO  A 207 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLU B  64
GLY B  85
LEU B  83
ASN B  37
PRO E 136
1.29A
None
None
None
None
EDO  B 202 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE E 132
SER E 128
SER E 139
VAL E  95
GLY E  79
1.72A
APR  E 201 (-3.5A)
APR  E 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.72A
APR  A 201 (-3.7A)
APR  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE E 132
SER E 128
SER E 139
VAL E  95
GLY E  79
1.71A
APR  E 201 (-3.5A)
APR  E 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.72A
APR  C 201 (-3.5A)
APR  C 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B  97
LEU B 127
GLY E 133
ASN B  37
ASN B 115
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.74A
APR  B 201 (-3.5A)
APR  B 201 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR D 146
VAL D 142
SER D 128
VAL D  95
ALA D 112
1.79A
None
None
APR  D 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D 165
THR D 149
TYR D 152
PRO D  32
GLY E   8
1.66A17.23
None
None
None
None
EDO  E 203 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR E 146
VAL E 142
SER E 128
VAL E  95
ALA E 112
1.78A
None
None
APR  E 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.71A
APR  C 201 (-3.5A)
APR  C 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  41
ASP E 145
ASP E 135
HIS E 138
GLY B  73
1.58A16.18
None
None
EDO  B 202 (-4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE D 132
SER D 128
SER D 139
VAL D  95
GLY D  79
1.73A
APR  D 201 (-3.3A)
APR  D 201 (-4.3A)
None
None
EDO  D 203 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.78A
None
None
APR  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.60A
APR  A 201 (-4.1A)
APR  A 201 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE D 132
SER D 128
SER D 139
VAL D  95
GLY D  79
1.74A
APR  D 201 (-3.3A)
APR  D 201 (-4.3A)
None
None
EDO  D 203 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.78A
None
None
APR  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  79
GLY A  78
GLY D  78
ASN D 117
PRO D  98
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  41
ASP E 145
ASP E 135
HIS E 138
GLY B  73
1.59A16.18
None
None
EDO  B 202 (-4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  79
GLY D  78
GLY A  78
ASN A 117
PRO A  98
1.61A
EDO  D 203 (-3.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY E  47
GLY E  46
HIS E  94
ASN E  54
PRO E  32
1.71A
APR  E 201 (-4.4A)
APR  E 201 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.78A
None
None
APR  B 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  97
LEU D 127
VAL D 142
ASN D 115
GLN A 118
1.75A
None
None
None
EDO  A 207 ( 3.7A)
EDO  D 203 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 165
THR E 149
TYR E 152
PRO E  32
GLY D   8
1.74A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B  47
GLY B  46
HIS B  94
ASN B  54
PRO B  32
1.61A
APR  B 201 (-3.6A)
EDO  B 202 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.78A
None
None
APR  B 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  48
VAL D  24
ASP C  67
HIS C  86
ASN C  59
1.65A
EDO  D 204 ( 3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 126
LEU B 140
ALA B 129
ASP B 157
ASP B 162
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.78A
None
None
MES  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.72A
MES  A 201 (-3.5A)
MES  A 201 (-4.4A)
None
None
EDO  A 204 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.72A
MES  C 201 (-3.6A)
MES  C 201 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  97
LEU A 127
VAL A 142
ASN A 115
GLN C 118
1.74A
None
None
None
EDO  A 202 ( 3.5A)
EDO  A 204 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  47
GLY A  46
HIS A  94
ASN A  54
PRO A  32
1.53A
MES  A 201 ( 4.8A)
MES  A 201 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  97
LEU C 127
VAL C 142
ASN C 115
GLN A 118
1.78A
None
None
None
EDO  A 202 (-3.6A)
EDO  A 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  79
GLY C  78
GLY A  78
ASN A 117
PRO A  98
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  97
GLY C  73
HIS C  94
ASN C 115
GLN A 118
1.65A
None
None
None
EDO  A 202 (-3.6A)
EDO  A 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  47
GLY C  46
HIS C  94
ASN C  54
PRO C  32
1.53A
MES  C 201 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 132
SER A 128
SER A 139
VAL A  95
GLY A  79
1.71A
MES  A 201 (-3.5A)
MES  A 201 (-4.4A)
None
None
EDO  A 204 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP A 157
ASP B 145
ASN B 117
1.50A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR C 146
VAL C 142
SER C 128
VAL C  95
ALA C 112
1.78A
None
None
MES  C 201 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  79
GLY A  78
GLY C  78
ASN C 117
PRO C  98
1.59A
EDO  A 204 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
SER C 128
SER C 139
VAL C  95
GLY C  79
1.73A
MES  C 201 (-3.6A)
MES  C 201 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B  47
GLY B  46
HIS B  94
ASN B  54
PRO B  32
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
SER B 128
SER B 139
VAL B  95
GLY B  79
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR C 146
VAL C 142
SER C 128
VAL C  95
ALA C 112
1.79A
None
None
MES  C 201 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  79
LEU A 108
GLY A 130
ASP A 105
ASN C 117
1.79A
EDO  A 204 (-3.6A)
EDO  C 205 (-4.9A)
MES  A 201 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  97
GLY A  73
HIS A  94
ASN A 115
GLN C 118
1.62A
None
None
None
EDO  A 202 ( 3.5A)
EDO  A 204 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR B 146
VAL B 142
SER B 128
VAL B  95
ALA B 112
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 126
LEU C 140
ALA C 129
ASP C 157
ASP C 162
1.77A
None
None
None
MG  C 202 ( 2.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
THR A 146
VAL A 142
SER A 128
VAL A  95
ALA A 112
1.77A
None
None
MES  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.80A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		7btf NSP12
(SARS-CoV-2)		5 / 12
THR A 538
VAL A 398
THR A 565
ASP A 684
GLN A 541
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		7btf NSP12
(SARS-CoV-2)		5 / 10
THR A 680
GLY A 678
LEU A 663
PHE A 694
VAL A 315
1.66A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 652
SER A 649
ASN A 534
VAL A 535
ALA A 656
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 758
VAL A 588
GLY A 679
ASP A 623
ASN A 695
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7btf NSP12
(SARS-CoV-2)		5 / 12
GLN A 789
PHE A  45
ASP A  36
ASP A 465
HIS A 133
1.67A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
THR A 344
GLY A 345
VAL A 353
ASP B 112
ASN A 297
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7btf NSP12
(SARS-CoV-2)		5 / 12
THR A 710
ASN A 767
VAL A 776
GLY A 774
ALA A 706
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		7btf NSP12
(SARS-CoV-2)		5 / 12
THR A 148
LEU A 212
VAL A 182
ASP A 211
ASN A 213
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
LEU C  41
GLY A 413
ASP C  38
ASN C  37
GLN A 444
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7btf NSP12
(SARS-CoV-2)		5 / 12
THR A 710
ASN A 767
VAL A 776
GLY A 774
ALA A 706
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7btf NSP12
(SARS-CoV-2)		5 / 10
THR A 710
PHE A 745
ASN A 767
VAL A 776
GLY A 774
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASP A 390
ASP A 452
ASN A 552
1.58A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 652
SER A 649
ASN A 534
VAL A 535
ALA A 656
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7btf NSP12
(SARS-CoV-2)		5 / 12
GLN A 789
PHE A  45
ASP A  36
ASP A 465
HIS A 133
1.67A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A  27
VAL A  20
GLY A 170
HIS A  41
1.74A
JRY  A 401 (-3.3A)
None
None
None
JRY  A 401 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 157
TYR A 182
TYR A 161
VAL A  13
CYH A  16
1.79A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
THR A 687
THR A 538
VAL A 560
GLY A 683
ALA A 558
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
THR A 680
GLY A 678
LEU A 663
PHE A 694
VAL A 315
1.59A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 789
PHE A  45
ASP A  36
ASP A 465
HIS A 133
1.75A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
THR A 687
THR A 538
VAL A 560
GLY A 683
ALA A 558
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 789
PHE A  45
ASP A  36
ASP A 465
HIS A 133
1.80A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLY A 839
GLY A 841
LEU A 838
GLU A 811
ARG A 836
1.61A
None
None
None
None
U  P  18 ( 2.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
THR A 687
THR A 538
VAL A 560
GLY A 683
ALA A 558
1.77A
F86  P 102 (-3.6A)
None
U  T  10 ( 4.6A)
U  T  10 ( 3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
THR A 687
THR A 538
VAL A 560
GLY A 683
ALA A 558
1.75A
F86  P 102 (-3.6A)
None
U  T  10 ( 4.6A)
U  T  10 ( 3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
THR A 344
GLY A 345
VAL A 353
ASP B 112
ASN A 297
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
THR A 680
GLY A 678
LEU A 663
PHE A 694
VAL A 315
1.69A20.70
F86  P 102 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLN A 789
PHE A  45
ASP A  36
ASP A 465
HIS A 133
1.77A21.65
None