Ligand ID: LAX


Drugbank ID:
DB00154
(Dihomo-gamma-linolenic acid)


Indication:
For nutritional supplementation, also for treating dietary shortage or imbalance

Get human targets for LAX in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'LAX'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 10
VAL B 233
TYR B 237
ASN B 221
ILE B 286
LEU B 268
1.45A18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		6 / 10
VAL B 110
PHE B  56
VAL B  41
TYR B  32
ASN B  27
LEU B  45
1.77A11.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		1z1i 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 220
GLY A 258
SER A 254
GLY A 251
LEU A 250
1.51A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 10
VAL B 233
TYR B 237
ASN B 221
ILE B 286
LEU B 268
1.48A18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.43A18.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2c3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.30A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL B 233
TYR B 237
ASN B 221
ILE B 286
LEU B 268
1.40A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B 220
GLY B 258
SER B 254
GLY B 251
LEU B 250
1.51A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU H 141
PHE H 122
ALA L 131
SER L 181
GLY L 159
1.50A15.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU B 118
TYR B 113
PHE B 128
TYR B 137
LEU B 174
1.46A19.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE C 501
PHE C 416
PHE C 387
ALA C 398
GLY C 368
1.57A15.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
PHE B 275
LEU B 354
PHE B 308
GLY B 296
LEU B 292
1.23A11.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		5 / 10
ARG A  48
PHE A  32
VAL A  86
VAL A  62
LEU A 108
1.46A11.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2liz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 204
VAL A 233
TYR A 237
ASN A 221
LEU A 268
1.35A11.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2og3 NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		6 / 12
PHE A  54
PHE A 111
TYR A 113
GLY A  86
ALA A 135
GLY A  72
1.58A12.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 10
VAL B 233
TYR B 237
ASN B 221
ILE B 286
LEU B 268
1.44A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
LEU B 220
GLY B 258
SER B 254
GLY B 251
LEU B 250
1.56A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 10
VAL B 233
TYR B 237
ASN B 221
ILE B 286
LEU B 268
1.45A19.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.42A18.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.42A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU E 263
PHE E 240
GLY E 286
ALA E 283
GLY F 164
1.56A19.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 10
VAL B 233
TYR B 237
ASN B 221
ILE B 286
LEU B 268
1.47A18.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2wct NSP3
(SARSr-CoV)		5 / 12
TYR D 583
PHE B 406
GLY D 609
ALA D 620
LEU D 627
1.44A19.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.29A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.47A18.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3e9s NSP3
(SARSr-CoV)		5 / 12
LEU A 118
TYR A 113
PHE A 128
TYR A 137
LEU A 174
1.51A19.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.20A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.36A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.44A18.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL B 233
TYR B 237
ASN B 221
ILE B 286
LEU B 268
1.51A19.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.48A18.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A 118
TYR A 113
PHE A 128
TYR A 137
LEU A 174
1.49A19.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3sci SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
TYR E 410
TRP E 340
ALA E 384
SER E 500
GLY E 418
1.42A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3scj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
TYR E 410
TRP E 340
ALA E 384
SER E 500
GLY E 418
1.45A15.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.40A18.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A 118
TYR A 113
PHE A 128
TYR A 137
LEU A 174
1.51A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.34A18.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU D 118
TYR D 113
PHE D 128
TYR D 137
LEU D 174
1.57A19.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE C 501
PHE C 416
PHE C 387
ALA C 398
GLY C 368
1.49A18.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
LEU A 273
TYR A 332
PHE A 281
SER A 267
GLY A 255
1.50A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
PHE C 130
LEU C 222
TYR C 195
GLY C 225
GLY C 104
1.50A18.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
LEU B 273
TYR B 332
PHE B 281
SER B 267
GLY B 255
1.50A18.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
VAL A 114
TYR A 197
VAL A 196
ASN C 381
LEU A 222
1.47A18.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
VAL B 510
VAL B 382
TYR B 383
ASN B 530
LEU B 503
1.41A18.48
VAL  B 510 ( 0.5A)
VAL  B 382 ( 0.6A)
TYR  B 383 ( 1.3A)
ASN  B 530 ( 0.6A)
LEU  B 503 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 10
VAL A 206
PHE A 148
TYR A 137
VAL A 126
LEU A 174
1.52A18.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5zvm SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE A 952
GLY A 953
ALA A 954
SER A 956
LEU A 959
1.52A8.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ack ACE2
(Homo
sapiens)		5 / 12
LEU D 568
GLY D 561
ALA D 396
SER D 563
LEU D  95
1.54A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
VAL A 510
VAL A 382
TYR A 383
ASN A 530
LEU A 503
1.38A18.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE C 130
LEU C 222
TYR C 195
GLY C 225
GLY C 104
1.36A18.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
ARG A 758
PHE A1044
VAL A1015
VAL A1042
VAL A 711
1.48A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
TYR B 410
TRP B 340
ALA B 384
SER B 500
GLY B 418
1.30A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU B  64
TYR B  26
PHE B  30
GLY A  26
LEU A  32
1.27A10.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 10
VAL A 915
VAL C 915
ASN B 914
ILE A 923
LEU A 916
1.52A13.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LEU C 127
TYR C 129
PHE C 473
ALA C 489
GLY C 591
1.30A21.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6m1d ACE2
(Homo
sapiens)		5 / 10
VAL D 212
PHE D 525
VAL D 404
VAL D 573
ASN D 397
1.51A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE C   3
PHE C 305
GLY A 124
ALA A 116
GLY C   2
1.73A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE D   3
PHE D 305
GLY B 124
ALA B 116
GLY D   2
1.75A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		6 / 12
PHE D  54
PHE D 111
TYR D 113
GLY D  86
ALA D 135
GLY D  72
1.58A13.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6m71 NSP12
(SARS-CoV-2)		5 / 10
PHE A 480
VAL A 693
TYR A 483
ASN A 695
LEU A 758
1.50A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
PHE A 504
LEU B 117
GLY A 385
ALA A 399
GLY A 671
1.69A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6m71 NSP12
(SARS-CoV-2)		5 / 10
PHE A 745
VAL A 475
VAL A 476
ASN A 705
ILE A 757
1.67A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
PHE A 165
LEU A 146
TYR A 122
TRP A 162
ALA A 130
1.73A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6m71 NSP12
(SARS-CoV-2)		5 / 10
PHE A 480
VAL A 693
TYR A 483
ASN A 691
LEU A 576
1.78A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
PHE A 428
PHE A 419
TYR A 884
GLY A 841
ALA A 840
1.44A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 10
VAL A 341
PHE A 396
VAL A 675
ILE B 106
LEU B 117
1.77A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6m71 NSP12
(SARS-CoV-2)		5 / 10
PHE A 471
VAL A 700
ASN A 743
ILE A 757
LEU A 749
1.78A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		5 / 12
PHE H  68
TYR H  94
GLY H   9
ALA H  10
LEU H  86
1.26A15.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6nur NSP12
(SARSr-CoV)		5 / 10
PHE A 480
VAL A 693
TYR A 483
ASN A 695
LEU A 758
1.53A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL B 341
VAL B 511
ASN B 394
ILE B 410
LEU B 513
1.48A18.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR C 279
PHE B 562
ALA C 222
SER C 221
GLY C 219
1.52A18.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6vxs NSP3
(SARS-CoV-2)		5 / 10
VAL B  95
PHE B   6
VAL B  30
VAL B 121
VAL B 151
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6vxs NSP3
(SARS-CoV-2)		5 / 10
VAL A  77
TYR A 113
VAL A 142
ASN A  99
ILE A 137
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6vxs NSP3
(SARS-CoV-2)		5 / 10
VAL B 144
ARG B 141
VAL B 155
TYR B 161
LEU B 140
1.74A
None
None
SO4  B 204 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6vxs NSP3
(SARS-CoV-2)		5 / 10
VAL A  95
PHE A   6
VAL A  30
VAL A 121
VAL A 151
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6vxs NSP3
(SARS-CoV-2)		5 / 10
PHE A 116
VAL A  95
VAL A 142
ILE A 137
LEU A 109
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE A 515
PHE A 429
PHE A 400
ALA A 411
GLY A 381
1.52A18.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		6 / 12
PHE D  53
PHE D 110
TYR D 112
GLY D  85
ALA D 134
GLY D  71
1.58A12.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w02 NSP3
(SARS-CoV-2)		5 / 12
LEU A 160
GLY A 133
ALA A 134
GLY A  97
LEU A 127
1.56A15.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 10
VAL C 350
VAL C 510
VAL C 433
ILE H  98
LEU C 425
1.62A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU C 390
TYR C 365
PHE C 392
GLY C 381
GLY H  95
1.58A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
PHE C 515
PHE C 429
PHE C 400
ALA C 411
GLY C 381
1.69A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
PHE L  62
TYR L 173
TYR L  86
ALA L  12
LEU L  78
1.76A14.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
PHE L  62
TYR L 140
TYR L  86
ALA L  12
LEU L  78
1.68A14.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6898
GLY A6869
ALA A6870
SER A6896
LEU A6909
1.71A
SAM  A7104 (-4.4A)
SAM  A7104 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE B 116
LEU B 164
ALA B 129
GLY B  97
LEU B 109
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 160
GLY B 133
ALA B 134
GLY B  97
LEU B 127
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w6y NSP3
(SARS-CoV-2)		5 / 10
VAL B  95
PHE B   6
VAL B  30
VAL B 121
VAL B 151
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w6y NSP3
(SARS-CoV-2)		5 / 10
PHE B 116
VAL B  95
VAL B 142
ILE B 137
LEU B 109
1.80A13.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w6y NSP3
(SARS-CoV-2)		5 / 10
VAL A 165
PHE A 116
VAL A 147
VAL A 151
LEU A 140
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w6y NSP3
(SARS-CoV-2)		5 / 10
VAL B 165
PHE B 116
VAL B 147
VAL B 151
LEU B 140
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 160
GLY A 133
ALA A 134
GLY A  97
LEU A 127
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w6y NSP3
(SARS-CoV-2)		5 / 10
PHE A 116
VAL A  95
VAL A 142
ILE A 137
LEU A 109
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w6y NSP3
(SARS-CoV-2)		5 / 10
VAL B  77
TYR B 113
VAL B 142
ASN B  99
ILE B 137
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE A 116
LEU A 164
ALA A 129
GLY A  97
LEU A 109
1.70A
None
None
AMP  A 201 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w6y NSP3
(SARS-CoV-2)		5 / 10
VAL A  77
TYR A 113
VAL A 142
ASN A  99
ILE A 137
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6898
GLY A6869
ALA A6870
SER A6896
LEU A6909
1.65A13.13
SAM  A7102 ( 3.8A)
SAM  A7102 ( 3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6898
GLY C6869
ALA C6870
SER C6896
LEU C6909
1.65A13.13
SAM  C7105 ( 3.8A)
SAM  C7105 ( 3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C 162
TRP A 106
GLY A 160
GLY B 160
LEU B 162
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 162
TRP B 106
GLY B 160
GLY C 160
LEU C 162
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
LEU A  88
GLY A 104
ALA A 107
SER A 105
LEU A  -8
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wcf NSP3
(SARS-CoV-2)		5 / 10
VAL A  77
TYR A 113
VAL A 142
ASN A  99
ILE A 137
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
GLY A 130
ALA A 129
SER A 128
LEU A 109
1.59A
MES  A 201 (-2.5A)
MES  A 201 (-3.2A)
None
MES  A 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
GLY A 130
ALA A 129
GLY A  97
LEU A 127
1.67A
MES  A 201 (-2.5A)
MES  A 201 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
GLY A 133
ALA A 134
GLY A  97
LEU A 127
1.60A
MES  A 201 (-2.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 160
GLY A 133
ALA A 134
GLY A  97
LEU A 127
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wen NSP3
(SARS-CoV-2)		5 / 10
VAL A  77
TYR A 113
VAL A 142
ASN A  99
ILE A 137
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wen NSP3
(SARS-CoV-2)		5 / 10
VAL A 165
PHE A 116
VAL A 147
VAL A 151
LEU A 140
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wen NSP3
(SARS-CoV-2)		5 / 12
PHE A 116
LEU A 164
ALA A 129
GLY A  97
LEU A 109
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wen NSP3
(SARS-CoV-2)		5 / 10
PHE A 116
VAL A  95
VAL A 142
ILE A 137
LEU A 109
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wey NSP3
(SARS-CoV-2)		5 / 10
VAL A 299
PHE A 210
VAL A 234
VAL A 325
VAL A 355
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wey NSP3
(SARS-CoV-2)		5 / 10
PHE A 320
VAL A 299
VAL A 346
ILE A 341
LEU A 313
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wey NSP3
(SARS-CoV-2)		5 / 10
VAL A 281
TYR A 317
VAL A 346
ASN A 303
ILE A 341
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wey NSP3
(SARS-CoV-2)		5 / 12
PHE A 320
LEU A 368
ALA A 333
GLY A 301
LEU A 313
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
TYR C 333
GLY C 335
ALA C 336
SER C 318
GLY C 316
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
TYR F 333
GLY F 335
ALA F 336
SER F 318
GLY F 316
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE D 314
GLY C 335
ALA C 336
SER C 318
GLY D 284
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE E 314
GLY F 335
ALA F 336
SER F 318
GLY E 284
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
LEU A6898
PHE A6868
GLY A6869
ALA A6870
SER A6896
LEU A6909
1.68A
SAH  A7102 (-3.9A)
None
SAH  A7102 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
LEU C6898
PHE C6868
GLY C6869
ALA C6870
SER C6896
LEU C6909
1.66A
SAH  C7102 (-4.2A)
None
SAH  C7102 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		6 / 12
PHE C  53
PHE C 110
TYR C 112
GLY C  85
ALA C 134
GLY C  71
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
VAL C  72
VAL C 133
ASN D  77
ILE C 130
LEU C  64
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		6 / 12
PHE D  53
PHE D 110
TYR D 112
GLY D  85
ALA D 134
GLY D  71
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		6 / 12
PHE B  53
PHE B 110
TYR B 112
GLY B  85
ALA B 134
GLY B  71
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wkq NSP16
(SARS-CoV-2)		6 / 12
LEU A6898
PHE A6868
GLY A6869
ALA A6870
SER A6896
LEU A6909
1.68A
SFG  A7103 ( 3.9A)
None
SFG  A7103 ( 3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wkq NSP16
(SARS-CoV-2)		6 / 12
LEU C6898
PHE C6868
GLY C6869
ALA C6870
SER C6896
LEU C6909
1.67A
SFG  C7103 ( 3.9A)
None
SFG  C7103 ( 3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
VAL A   6
VAL A 102
ASN A  53
ILE A 108
LEU A  58
1.60A
None
None
EDO  A 403 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
VAL B   6
VAL B 102
ASN B  53
ILE B 108
LEU B  58
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
VAL B  25
VAL B  54
VAL B  52
ILE B  28
LEU B   3
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL C 165
PHE C 116
VAL C 147
VAL C 151
LEU C 140
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A 116
LEU A 164
ALA A 129
GLY A  97
LEU A 109
1.78A
None
None
APR  A 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL C 165
PHE C 116
VAL C 147
VAL C  16
LEU C 140
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL D  95
PHE D   6
VAL D  30
VAL D 121
VAL D 151
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL B  77
TYR B 113
VAL B 142
ASN B  99
ILE B 137
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A 156
GLY A 130
ALA A 129
GLY A  97
LEU A 127
1.58A
APR  A 201 (-4.7A)
APR  A 201 (-3.5A)
APR  A 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE C 156
GLY C 130
ALA C 129
GLY C  97
LEU C 127
1.57A
APR  C 201 (-4.7A)
APR  C 201 (-3.0A)
APR  C 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE C 132
GLY C 133
ALA C 134
GLY C  97
LEU C 127
1.61A
APR  C 201 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE D 156
GLY D 130
ALA D 129
GLY D  97
LEU D 127
1.56A
APR  D 201 (-4.5A)
APR  D 201 (-3.2A)
APR  D 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL D  77
TYR D 113
VAL D 142
ASN D  99
ILE D 137
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL D 165
PHE D 116
VAL D 147
VAL D  16
LEU D 140
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE B 132
GLY B 130
ALA B 129
GLY B  97
LEU B 127
1.68A
APR  B 201 (-3.6A)
APR  B 201 (-3.3A)
APR  B 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE B 132
GLY B 133
ALA B 134
GLY B  97
LEU B 127
1.64A
APR  B 201 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE C 132
GLY C 130
ALA C 129
SER C 128
LEU C 109
1.64A
APR  C 201 (-3.5A)
APR  C 201 (-3.0A)
APR  C 201 (-3.7A)
APR  C 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A 132
GLY A 130
ALA A 129
SER A 128
LEU A 109
1.65A
APR  A 201 (-3.1A)
APR  A 201 (-3.5A)
APR  A 201 (-3.7A)
APR  A 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE C 132
GLY C 130
ALA C 129
GLY C  97
LEU C 127
1.65A
APR  C 201 (-3.5A)
APR  C 201 (-3.0A)
APR  C 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE D 132
GLY D 130
ALA D 129
SER D 128
LEU D 109
1.62A
APR  D 201 (-3.5A)
APR  D 201 (-3.2A)
APR  D 201 (-3.7A)
APR  D 201 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE D 116
GLY D  97
ALA D  38
SER D 128
GLY D 133
1.67A
None
None
APR  D 201 (-3.2A)
APR  D 201 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE B 156
GLY B 130
ALA B 129
GLY B  97
LEU B 127
1.54A
APR  B 201 (-4.6A)
APR  B 201 (-3.3A)
APR  B 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL D 165
PHE D 116
VAL D 147
VAL D 151
LEU D 140
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL A  77
TYR A 113
VAL A 142
ASN A  99
ILE A 137
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL A 165
PHE A 116
VAL A 147
VAL A 151
LEU A 140
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL C  77
TYR C 113
VAL C 142
ASN C  99
ILE C 137
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE D 116
LEU D 164
ALA D 129
GLY D  97
LEU D 109
1.80A
None
None
APR  D 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL B  95
PHE B   6
VAL B  30
VAL B 121
VAL B 151
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE C 116
LEU C 164
ALA C 129
GLY C  97
LEU C 109
1.77A
None
None
APR  C 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE B 116
LEU B 164
ALA B 129
GLY B  97
LEU B 109
1.78A
None
None
APR  B 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL B 165
PHE B 116
VAL B 147
VAL B 151
LEU B 140
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE B 132
GLY B 130
ALA B 129
SER B 128
LEU B 109
1.63A
APR  B 201 (-3.6A)
APR  B 201 (-3.3A)
APR  B 201 (-3.7A)
APR  B 201 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6898
GLY A6869
ALA A6870
SER A6896
LEU A6909
1.73A
SAH  A7101 (-4.3A)
SAH  A7101 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6868
GLY A6869
ALA A6870
SER A6896
LEU A6909
1.78A
None
SAH  A7101 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
VAL B 115
VAL A  12
VAL A  66
ILE A  68
LEU A  60
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
VAL D 115
VAL C  12
VAL C  66
ILE C  68
LEU C  60
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
PHE A 127
LEU A 101
PHE A 147
TYR A 136
ALA A 114
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 10
ARG B 111
VAL B 131
VAL B 115
ASN B 136
ILE B 107
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 10
VAL D 115
VAL C  12
VAL C  66
ILE C  68
LEU C  60
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
PHE A  13
PHE A  70
TYR A  72
GLY A  45
ALA A  94
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
PHE A  70
TYR A  72
GLY A  45
ALA A  94
GLY A  31
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 10
VAL E 350
VAL E 510
VAL E 433
ILE H 102
LEU E 425
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL A 341
VAL A 511
ASN A 394
ILE A 410
LEU A 513
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 515
PHE E 429
PHE E 400
ALA E 411
GLY E 381
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE A 515
PHE A 429
PHE A 400
ALA A 411
GLY A 381
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE C  68
TYR C 179
TYR C  92
ALA C  12
LEU C  84
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE L  68
TYR L 179
TYR L  92
ALA L  12
LEU L  84
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 515
PHE E 429
PHE E 400
ALA E 411
GLY E 381
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE L  68
TYR L 179
TYR L  92
ALA L  12
LEU L  84
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE L  68
TYR L 146
TYR L  92
ALA L  12
LEU L  84
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
VAL E 341
VAL E 511
ASN E 394
ILE E 410
LEU E 513
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
PHE L  68
TYR L 146
TYR L  92
ALA L  12
LEU L  84
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 10
VAL E 350
VAL E 510
VAL E 433
ILE H 102
LEU E 425
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 10
VAL A 350
VAL A 510
VAL A 433
ILE B 102
LEU A 425
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 515
PHE E 429
PHE E 400
ALA E 411
GLY E 381
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE A 515
PHE A 429
PHE A 400
ALA A 411
GLY A 381
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL D 165
PHE D 116
VAL D 147
VAL D 151
LEU D 140
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 116
LEU C  43
TYR C  42
GLY C  79
LEU C 127
1.70A
None
None
None
EPE  C 202 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
PHE D 116
VAL D  95
VAL D 142
ILE D 137
LEU D 109
1.75A
None
None
None
None
EDO  D 204 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE D 116
LEU D  43
TYR D  42
GLY D  79
LEU D 127
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL E  77
TYR E 113
VAL E 142
ASN E  99
ILE E 137
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 116
LEU B 164
ALA B 129
GLY B  97
LEU B 109
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL C 165
PHE C 116
VAL C 147
VAL C 151
LEU C 140
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL B  77
TYR B 113
VAL B 142
ASN B  99
ILE B 137
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 116
LEU C 164
ALA C 129
GLY C  97
LEU C 109
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL A 165
PHE A 116
VAL A 147
VAL A 151
LEU A 140
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE D 116
LEU D 164
ALA D 129
GLY D  97
LEU D 109
1.69A
None
None
EDO  D 205 (-4.5A)
None
EDO  D 204 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE E 116
LEU E 164
ALA E 129
GLY E  97
LEU E 109
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL A  77
TYR A 113
VAL A 142
ASN A  99
ILE A 137
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 160
GLY D 133
ALA D 134
GLY D  97
LEU D 127
1.54A
None
None
EDO  D 211 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
PHE B 116
VAL B  95
VAL B 142
ILE B 137
LEU B 109
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
PHE C 116
VAL C  95
VAL C 142
ILE C 137
LEU C 109
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL E  95
PHE E   6
VAL E  30
VAL E 121
VAL E 151
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL C  77
TYR C 113
VAL C 142
ASN C  99
ILE C 137
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
PHE A 116
VAL A  95
VAL A 142
ILE A 137
LEU A 109
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL B 165
PHE B 116
VAL B 147
VAL B 151
LEU B 140
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 116
LEU A 164
ALA A 129
GLY A  97
LEU A 109
1.68A
None
None
None
EDO  A 202 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL C 165
PHE C 116
VAL C 147
VAL C  16
LEU C 140
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL E 165
PHE E 116
VAL E 147
VAL E 151
LEU E 140
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL D  77
TYR D 113
VAL D 142
ASN D  99
ILE D 137
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL D  96
TYR D 113
VAL D 142
ASN D  99
ILE D 137
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL E  96
TYR E 113
VAL E 142
ASN E  99
ILE E 137
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL A  77
TYR A 113
VAL A 142
ASN A  99
ILE A 137
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL E  95
PHE E   6
VAL E  30
VAL E 121
VAL E 151
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 160
GLY A 133
ALA A 134
GLY A  97
LEU A 127
1.63A
None
EDO  A 205 (-3.4A)
EDO  A 204 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL B  77
TYR B 113
VAL B 142
ASN B  99
ILE B 137
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL D 165
PHE D 116
VAL D 147
VAL D 151
LEU D 140
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL D  77
TYR D 113
VAL D 142
ASN D  99
ILE D 137
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL E 165
PHE E 116
VAL E 147
VAL E 151
LEU E 140
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
PHE D 116
VAL D  95
VAL D 142
ILE D 137
LEU D 109
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE E 116
LEU E  43
TYR E  42
GLY E  79
LEU E 127
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL B 165
PHE B 116
VAL B 147
VAL B 151
LEU B 140
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL E  77
TYR E 113
VAL E 142
ASN E  99
ILE E 137
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE E 132
PHE B 156
GLY B  48
ALA B  52
GLY E 130
1.68A
APR  E 201 (-3.5A)
None
APR  B 201 (-3.5A)
APR  B 201 ( 4.0A)
APR  E 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 160
GLY D 133
ALA D 134
GLY D  97
LEU D 127
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 160
GLY C 133
ALA C 134
GLY C  97
LEU C 127
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL C  77
TYR C 113
VAL C 142
ASN C  99
ILE C 137
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE D 116
LEU D  43
TYR D  42
GLY D  79
LEU D 127
1.63A
None
None
None
EDO  D 203 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL C 165
PHE C 116
VAL C 147
VAL C 151
LEU C 140
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL A 165
PHE A 116
VAL A 147
VAL A 151
LEU A 140
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
PHE C 116
VAL C  95
VAL C 142
ILE C 137
LEU C 109
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL A  77
TYR A 113
VAL A 142
ASN A  99
ILE A 137
1.56A
None
None
None
None
EDO  A 206 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL B  77
TYR B 113
VAL B 142
ASN B  99
ILE B 137
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 160
GLY B 133
ALA B 134
GLY B  97
LEU B 127
1.58A
None
None
EDO  B 204 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL C 165
PHE C 116
VAL C 147
VAL C 151
LEU C 140
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
GLY C 130
ALA C 129
GLY C  97
LEU C 127
1.68A
MES  C 201 (-3.6A)
MES  C 201 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 116
LEU A 164
ALA A 129
GLY A  97
LEU A 109
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
PHE B 116
VAL B  95
VAL B 142
ILE B 137
LEU B 109
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 116
LEU C 164
ALA C 129
GLY C  97
LEU C 109
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 160
GLY C 133
ALA C 134
GLY C  97
LEU C 127
1.61A
EDO  C 203 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL B 165
PHE B 116
VAL B 147
VAL B 151
LEU B 140
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
PHE C 116
VAL C  95
VAL C 142
ILE C 137
LEU C 109
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL A 165
PHE A 116
VAL A 147
VAL A 151
LEU A 140
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL C  77
TYR C 113
VAL C 142
ASN C  99
ILE C 137
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 116
LEU B 164
ALA B 129
GLY B  97
LEU B 109
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
GLY C 133
ALA C 134
GLY C  97
LEU C 127
1.63A
MES  C 201 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7btf NSP12
(SARS-CoV-2)		5 / 10
PHE A 480
VAL A 693
TYR A 483
ASN A 691
LEU A 576
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7btf NSP12
(SARS-CoV-2)		5 / 10
PHE A 745
VAL A 475
VAL A 476
ASN A 705
ILE A 757
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
PHE A 504
LEU B 117
GLY A 385
ALA A 399
GLY A 671
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 10
VAL A 341
PHE A 396
VAL A 675
ILE B 106
LEU B 117
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7btf NSP12
(SARS-CoV-2)		5 / 10
PHE A 480
VAL A 693
TYR A 483
ASN A 695
LEU A 758
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 165
LEU A 146
TYR A 122
TRP A 162
ALA A 130
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7btf NSP12
(SARS-CoV-2)		5 / 12
TYR A 455
PHE A 407
GLY A 446
ALA A 448
GLY A 670
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
PHE A 480
VAL A 693
TYR A 483
ASN A 695
LEU A 758
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
PHE A 745
VAL A 475
VAL A 476
ASN A 705
ILE A 757
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
VAL A 476
VAL A 473
ASN A 790
ILE A 307
LEU A 469
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
PHE A 165
LEU A 146
TYR A 122
TRP A 162
ALA A 130
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 10
VAL A 341
PHE A 396
VAL A 675
ILE B 106
LEU B 117
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
PHE A 745
VAL A 475
VAL A 476
ASN A 705
ILE A 757
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
TYR A 455
PHE A 407
GLY A 446
ALA A 448
GLY A 670
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 10
ARG B 190
VAL A 405
VAL B 131
ASN A 403
LEU B 128
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
PHE A 480
VAL A 693
TYR A 483
ASN A 695
LEU A 758
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
PHE A 165
LEU A 146
TYR A 122
TRP A 162
ALA A 130
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
PHE A 504
LEU B 117
GLY A 385
ALA A 399
GLY A 671
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 10
VAL A 341
PHE A 396
VAL A 675
ILE B 106
LEU B 117
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
PHE A 480
VAL A 693
TYR A 483
ASN A 691
LEU A 576
1.78A
None
None
None
F86  P 102 (-4.2A)
None