Ligand ID: LAX


Drugbank ID:
DB00154
(Dihomo-gamma-linolenic acid)


Indication:
For nutritional supplementation, also for treating dietary shortage or imbalance

Get human targets for LAX in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'LAX' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 10
VAL B 233
TYR B 237
ASN B 221
ILE B 286
LEU B 268
1.45A18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		6 / 10
VAL B 110
PHE B  56
VAL B  41
TYR B  32
ASN B  27
LEU B  45
1.77A11.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		1z1i 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 220
GLY A 258
SER A 254
GLY A 251
LEU A 250
1.51A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 10
VAL B 233
TYR B 237
ASN B 221
ILE B 286
LEU B 268
1.48A18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.43A18.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2c3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.30A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL B 233
TYR B 237
ASN B 221
ILE B 286
LEU B 268
1.40A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B 220
GLY B 258
SER B 254
GLY B 251
LEU B 250
1.51A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU H 141
PHE H 122
ALA L 131
SER L 181
GLY L 159
1.50A15.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU B 118
TYR B 113
PHE B 128
TYR B 137
LEU B 174
1.46A19.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE C 501
PHE C 416
PHE C 387
ALA C 398
GLY C 368
1.57A15.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
PHE B 275
LEU B 354
PHE B 308
GLY B 296
LEU B 292
1.23A11.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		5 / 10
ARG A  48
PHE A  32
VAL A  86
VAL A  62
LEU A 108
1.46A11.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2liz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 204
VAL A 233
TYR A 237
ASN A 221
LEU A 268
1.35A11.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2og3 NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		6 / 12
PHE A  54
PHE A 111
TYR A 113
GLY A  86
ALA A 135
GLY A  72
1.58A12.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 10
VAL B 233
TYR B 237
ASN B 221
ILE B 286
LEU B 268
1.44A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
LEU B 220
GLY B 258
SER B 254
GLY B 251
LEU B 250
1.56A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 10
VAL B 233
TYR B 237
ASN B 221
ILE B 286
LEU B 268
1.45A19.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.42A18.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.42A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU E 263
PHE E 240
GLY E 286
ALA E 283
GLY F 164
1.56A19.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 10
VAL B 233
TYR B 237
ASN B 221
ILE B 286
LEU B 268
1.47A18.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		2wct NSP3
(SARSr-CoV)		5 / 12
TYR D 583
PHE B 406
GLY D 609
ALA D 620
LEU D 627
1.44A19.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.29A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.47A18.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3e9s NSP3
(SARSr-CoV)		5 / 12
LEU A 118
TYR A 113
PHE A 128
TYR A 137
LEU A 174
1.51A19.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.20A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.36A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.44A18.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL B 233
TYR B 237
ASN B 221
ILE B 286
LEU B 268
1.51A19.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.48A18.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A 118
TYR A 113
PHE A 128
TYR A 137
LEU A 174
1.49A19.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3sci SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
TYR E 410
TRP E 340
ALA E 384
SER E 500
GLY E 418
1.42A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3scj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
TYR E 410
TRP E 340
ALA E 384
SER E 500
GLY E 418
1.45A15.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.40A18.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A 118
TYR A 113
PHE A 128
TYR A 137
LEU A 174
1.51A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
VAL A 233
TYR A 237
ASN A 221
ILE A 286
LEU A 268
1.34A18.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU D 118
TYR D 113
PHE D 128
TYR D 137
LEU D 174
1.57A19.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE C 501
PHE C 416
PHE C 387
ALA C 398
GLY C 368
1.49A18.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
LEU A 273
TYR A 332
PHE A 281
SER A 267
GLY A 255
1.50A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
PHE C 130
LEU C 222
TYR C 195
GLY C 225
GLY C 104
1.50A18.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
LEU B 273
TYR B 332
PHE B 281
SER B 267
GLY B 255
1.50A18.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
VAL A 114
TYR A 197
VAL A 196
ASN C 381
LEU A 222
1.47A18.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
VAL B 510
VAL B 382
TYR B 383
ASN B 530
LEU B 503
1.41A18.48
VAL  B 510 ( 0.5A)
VAL  B 382 ( 0.6A)
TYR  B 383 ( 1.3A)
ASN  B 530 ( 0.6A)
LEU  B 503 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 10
VAL A 206
PHE A 148
TYR A 137
VAL A 126
LEU A 174
1.52A18.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		5zvm SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE A 952
GLY A 953
ALA A 954
SER A 956
LEU A 959
1.52A8.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ack ACE2
(Homo
sapiens)		5 / 12
LEU D 568
GLY D 561
ALA D 396
SER D 563
LEU D  95
1.54A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
VAL A 510
VAL A 382
TYR A 383
ASN A 530
LEU A 503
1.38A18.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE C 130
LEU C 222
TYR C 195
GLY C 225
GLY C 104
1.36A18.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
ARG A 758
PHE A1044
VAL A1015
VAL A1042
VAL A 711
1.48A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
TYR B 410
TRP B 340
ALA B 384
SER B 500
GLY B 418
1.30A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU B  64
TYR B  26
PHE B  30
GLY A  26
LEU A  32
1.27A10.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LEU C 127
TYR C 129
PHE C 473
ALA C 489
GLY C 591
1.30A21.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6m1d ACE2
(Homo
sapiens)		5 / 10
VAL D 212
PHE D 525
VAL D 404
VAL D 573
ASN D 397
1.51A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		5 / 12
PHE H  68
TYR H  94
GLY H   9
ALA H  10
LEU H  86
1.26A15.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6nur NSP12
(SARSr-CoV)		5 / 10
PHE A 480
VAL A 693
TYR A 483
ASN A 695
LEU A 758
1.53A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
PHE L  62
TYR L 173
TYR L  86
ALA L  12
LEU L  78
1.76A14.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
PHE L  62
TYR L 140
TYR L  86
ALA L  12
LEU L  78
1.68A14.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE C  68
TYR C 179
TYR C  92
ALA C  12
LEU C  84
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE L  68
TYR L 179
TYR L  92
ALA L  12
LEU L  84
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE L  68
TYR L 179
TYR L  92
ALA L  12
LEU L  84
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
PHE L  68
TYR L 146
TYR L  92
ALA L  12
LEU L  84
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
PHE L  68
TYR L 146
TYR L  92
ALA L  12
LEU L  84
1.67A
None