Ligand ID: K4D


Drugbank ID:
DB01195
(Flecainide)


Indication:
Flecainide is is a class Ic antiarrhythmic agent and as such, it is used for the prevention of paroxysmal supraventricular tachycardias (PSVT), including atrioventricular nodal reentrant tachycardia, atrioventricular reentrant tachycardia and other supraventricular tachycardias of unspecified mechanism associated with disablin.

Get human targets for K4D in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'K4D'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		4 / 6
LEU B  27
MET B 165
THR B 175
LEU B  30
1.44A20.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		1x7q HLA, A-11
(Homo
sapiens)		4 / 6
THR A 216
LEU A 215
THR A 225
LEU A 201
1.40A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B1027
MET B1165
THR B1175
LEU B1030
1.34A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.40A20.67
ENB  A 307 (-3.5A)
ENB  A 307 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU C 503
MET C 417
THR C 372
LEU C 377
1.45A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.32A20.62
AZP  A 401 ( 4.7A)
AZP  A 401 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.40A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.44A20.25
None
BEZ  A1303 (-3.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 6
THR A  82
LEU A  85
THR A 110
LEU A  94
1.31A22.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 6
THR A  82
LEU A  85
THR A 110
LEU A  94
1.28A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B  27
MET B 165
THR B 175
LEU B  30
1.43A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		3bgf F26G19 FAB
(Mus
musculus)		4 / 6
THR L 180
LEU L 179
THR H 178
LEU H 124
1.35A19.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
THR B 445
LEU B 444
THR B 519
LEU B 439
1.23A18.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B  27
MET B 165
THR B 175
LEU B  30
1.45A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		3i6g HLA, A-2
(Homo
sapiens)		4 / 6
THR A 216
LEU A 215
THR A 225
LEU A 201
1.40A22.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU C  27
MET C 165
THR C 175
LEU C  30
1.31A20.44
PJE  G   5 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 6
THR A  82
LEU A  85
THR A 110
LEU A  94
1.31A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
THR B 445
LEU B 444
THR B 519
LEU B 439
1.24A19.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.44A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 6
THR A 119
LEU A 122
THR A 308
LEU A 244
1.21A20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B  27
MET B 165
THR B 175
LEU B  30
1.39A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		5r81 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.42A21.98
None
RZJ  A1001 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
THR A 201
LEU A 242
MET A 264
LEU A 232
1.74A20.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.42A20.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
MET A 851
THR A 848
LEU A 847
THR B 678
0.96A13.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6acj ACE2
(Homo
sapiens)		4 / 6
THR D 445
LEU D 444
THR D 519
LEU D 439
1.00A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6cs2 ACE2
(Homo
sapiens)		4 / 6
THR D 445
LEU D 444
THR D 519
LEU D 439
1.29A18.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.45A22.22

None
DMS  A 401 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
THR A 201
LEU A 242
MET A 264
LEU A 232
1.76A22.22

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
THR A 201
LEU A 242
MET A 264
LEU A 232
1.76A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.54A21.98

None
N0A  D   2 ( 4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
MET A  82
LEU A  87
THR A 175
LEU A  30
1.57A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m17 ACE2
(Homo
sapiens)		4 / 6
THR B 445
LEU B 444
THR B 519
LEU B 439
1.16A16.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 6
THR A 131
MET A 432
THR A 466
LEU A 198
1.34A19.31
None
LEU  A 707 ( 4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
MET C  82
LEU C  87
THR C 175
LEU C  30
1.71A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU C  27
MET C 165
THR C 175
LEU C  30
1.51A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
THR C 201
LEU C 242
MET C 264
LEU C 232
1.77A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU D  27
MET D 165
THR D 175
LEU D  30
1.47A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
MET B  82
LEU B  87
THR B 175
LEU B  30
1.71A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
THR B 201
LEU B 242
MET B 264
LEU B 232
1.75A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
THR A 201
LEU A 242
MET A 264
LEU A 232
1.74A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU B  27
MET B 165
THR B 175
LEU B  30
1.48A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
MET A  82
LEU A  87
THR A 175
LEU A  30
1.66A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.49A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
THR D 201
LEU D 242
MET D 264
LEU D 232
1.74A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
MET D  82
LEU D  87
THR D 175
LEU D  30
1.68A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.49A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
THR A 201
LEU A 242
MET A 264
LEU A 232
1.78A21.98

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
THR A 870
LEU A 869
THR A 912
LEU A 883
1.60A14.74

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
THR A 248
LEU A 247
THR A 252
LEU A 316
1.55A14.74

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6vw1 ACE2
(Homo
sapiens)		4 / 6
THR B 445
LEU B 444
THR B 519
LEU B 439
1.21A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6w4h NSP16
(SARS-CoV-2)		4 / 6
THR A6880
LEU A6883
THR A6908
LEU A6892
1.26A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
THR A6880
LEU A6883
THR A6908
LEU A6892
1.29A18.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 6
THR A6846
LEU B4298
MET A6840
THR A6993
1.67A18.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
MET A  82
LEU A  87
THR A 175
LEU A  30
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
THR A 201
LEU A 242
MET A 264
LEU A 232
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.47A
X77  A 401 ( 3.9A)
X77  A 401 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6w75 NSP16
(SARS-CoV-2)		4 / 6
THR A6880
LEU A6883
THR A6908
LEU A6892
1.22A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 6
THR A6846
LEU B4298
MET A6840
THR A6993
1.67A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6w75 NSP16
(SARS-CoV-2)		4 / 6
THR C6880
LEU C6883
THR C6908
LEU C6892
1.26A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
THR B 115
LEU B 113
MET B 169
LEU B 162
1.69A
 CL  B 502 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
MET C 169
THR C 168
THR C 115
LEU C 162
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
MET A 169
THR A 168
THR A 115
LEU A 162
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
THR A 115
LEU A 113
MET A 169
LEU A 162
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
MET B 169
THR B 168
THR B 115
LEU B 162
1.32A
None
None
CL  B 502 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
THR C 115
LEU C 113
MET C 169
LEU C 162
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 6
THR A6846
LEU B4298
MET A6840
THR A6993
1.67A
None
FMT  B4403 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
THR C6880
LEU C6883
THR C6908
LEU C6892
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
THR A6880
LEU A6883
THR A6908
LEU A6892
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 6
THR C6846
LEU D4298
MET C6840
THR C6993
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
THR C6880
LEU C6883
THR C6908
LEU C6892
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 6
THR A6846
LEU B4298
MET A6840
THR A6993
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
THR A6908
LEU A6909
THR A6880
LEU A6898
1.48A
None
None
None
SFG  A7103 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
THR A6880
LEU A6883
THR A6908
LEU A6892
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
THR C6908
LEU C6909
THR C6880
LEU C6898
1.49A
None
None
None
SFG  C7103 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
THR A 201
LEU A 242
MET A 264
LEU A 232
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.49A
U5G  A 401 ( 4.0A)
U5G  A 401 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
MET A  82
LEU A  87
THR A 175
LEU A  30
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
THR A6880
LEU A6883
THR A6908
LEU A6892
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
THR A 201
LEU A 242
MET A 264
LEU A 232
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
MET A 169
THR A 168
THR A 115
LEU A 162
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
THR A 201
LEU A 242
MET A 264
LEU A 232
1.76A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.43A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
MET D  94
LEU D  98
MET B  94
LEU C  55
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
THR A 201
LEU A 242
MET A 264
LEU A 232
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
THR A 201
LEU A 242
MET A 264
LEU A 232
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.60A
PK8  A 401 ( 3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
THR A 201
LEU A 242
MET A 264
LEU A 232
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.49A
PJE  C   5 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
MET A  82
LEU A  87
THR A 175
LEU A  30
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
THR A 189
LEU A 186
THR A 206
LEU A 212
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
THR A 201
LEU A 242
MET A 264
LEU A 232
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
MET A  82
LEU A  87
THR A 175
LEU A  30
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  27
MET A 165
THR A 175
LEU A  30
1.45A
None
JRY  A 401 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
THR A 870
LEU A 869
THR A 912
LEU A 883
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
THR A 189
LEU A 186
THR A 206
LEU A 212
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
THR A 248
LEU A 247
THR A 252
LEU A 316
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
THR A 870
LEU A 869
THR A 912
LEU A 883
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
THR A 248
LEU A 247
THR A 252
LEU A 316
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
THR A 189
LEU A 186
THR A 206
LEU A 212
1.78A
None