Ligand ID: JN3


Drugbank ID:
DB01586
(Ursodeoxycholic acid)


Indication:
The drug reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want an alternative to surgery.

Get human targets for JN3 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'JN3'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
LEU A 253
ALA A 210
GLN A 299
ILE A 249
LEU A 250
1.40A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.43A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
PHE A  56
LEU A  44
LEU A  69
ARG A  55
1.38A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.33A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		1uk4 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 253
ALA A 210
GLN A 299
ILE A 249
LEU A 250
1.37A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE B1153
LYS B1150
ALA B1155
LEU A 944
LEU B 941
1.48A17.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU E 920
ASN D1168
GLN F 915
ILE F 916
1.30A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		5 / 12
TYR A  85
LEU A  81
ALA A 140
ASP A 116
HIS B  31
1.46A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 10
PHE B1223
ASN B1221
ALA B1267
LEU B1272
ASN B1274
LEU B1271
1.57A24.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU J  19
ASN H  20
LYS J  14
GLN I  31
1.55A14.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU C  20
ASN F  20
GLN E  15
ILE E  16
1.20A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		1zvb E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU C  20
ALA B  15
ASP B  22
ILE A  23
LEU A  20
1.43A15.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
LEU B 253
ALA B 210
GLN B 299
ILE B 249
LEU B 250
1.40A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		6 / 12
VAL D 346
LEU D 309
CYH D 325
VAL D 326
LEU D 194
PHE D 298
1.74A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 10
ARG H 116
ILE H 112
ALA H 115
LEU D  61
LEU D  65
1.38A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		4 / 7
PHE H  97
LEU H 100
LEU H 108
PRO H 121
1.21A23.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ajf ACE2
(Homo
sapiens)		4 / 6
ASN A 322
GLN A 305
ILE A 307
PHE A 369
1.55A13.20
NAG  A1322 (-1.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
LEU B 253
ALA B 210
ASP B 295
HIS B 246
ILE B 249
LEU B 250
1.79A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU B 920
ASN F1169
GLN C 915
ILE C 916
1.13A15.45
None
None
None
ACE  C 913 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE C 916
LYS C 914
ASN E1169
LEU E1179
ASN E1176
1.48A9.22
ACE  C 913 ( 4.1A)
ACE  C 913 ( 3.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2bx3 MAIN PROTEINASE
(SARS-COV
Sin2774)		4 / 7
PHE A 230
LEU A 205
LEU A 250
GLU A 270
1.42A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
MET D 323
ILE C 305
ILE C 338
TYR C 334
HIS D 335
1.77A21.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 12
LEU A  47
LEU A  15
GLN A  21
ASP A  17
LEU A  53
1.37A21.14
None
None
None
None
D10  B1099 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 7
PHE D  92
LEU D  88
LEU D  82
PRO D  11
ARG D  48
1.67A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 12
LEU D  47
LEU D  15
GLN D  21
ASP D  17
LEU D  53
1.37A19.35
None
None
None
None
D10  C1099 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PHE A 230
LEU A 205
LEU A 250
GLU A 270
1.44A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.40A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU S 499
ASN S 330
ILE S 345
PHE S 501
1.55A21.00
None
NAG  S1330 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
PHE C  80
LEU C  81
LEU C  59
PRO B  34
1.38A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
LYS B  93
PHE B  96
ASN B 111
ASN B  89
VAL B 160
1.51A22.58
None
None
None
None
BR  B 319 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		2fxp SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ALA B  34
LEU C  41
ASN C  38
LEU C  37
VAL C  33
1.34A13.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU E 499
ASN E 330
ILE E 345
PHE E 379
1.30A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		4 / 6
LEU D 210
LYS D 239
GLN D 138
PHE D 215
1.36A18.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		4 / 7
LEU D 153
PRO D 191
GLU D 211
ARG D 193
1.23A18.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PHE A 230
LEU A 205
LEU A 250
GLU A 270
1.38A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU A 122
ALA A  80
ILE A  99
GLN A 130
HIS A  14
1.45A15.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2jzf REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU A 627
ALA A 629
HIS A 539
ILE A 525
LEU A 526
1.48A24.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		5 / 10
ASN A  29
ALA A  33
LEU A 105
LEU A  25
VAL A  52
1.14A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		4 / 6
LEU A  58
LYS A  83
GLN A   5
ILE A   7
1.45A23.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2kys NSP7
(SARSr-CoV)		5 / 12
LEU A  61
LEU A  22
ALA A  67
HIS A  38
LEU A  57
1.52A22.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		4 / 7
PHE A 172
LEU A 162
GLU A  64
ARG A  66
1.44A20.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.41A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
LEU B 253
ALA B 210
GLN B 299
ILE B 249
LEU B 250
1.46A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU A 245
ILE A 280
THR A 281
ASP B  36
ILE A 269
1.48A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
THR D  47
LEU D  49
VAL D 101
THR D  98
HIS D  95
1.44A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.41A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
LEU A 253
ALA A 210
GLN A 299
ILE A 249
LEU A 250
1.45A15.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.44A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU F 122
ALA F  80
ILE F  99
GLN F 130
HIS F  14
1.41A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
PHE A  55
LEU A   2
LEU E   2
GLU A  41
1.42A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.41A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 10
PHE B 140
ASN A 214
ALA A 211
LEU A 287
LEU A 208
1.38A22.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2wct NSP3
(SARSr-CoV)		4 / 7
LEU C 413
LEU C 421
GLU C 402
ARG C 430
1.23A22.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.41A18.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		5 / 10
ILE S 345
LYS S 323
ALA S 384
LEU S 499
VAL S 497
1.54A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3bgf F26G19 FAB
(Mus
musculus)		4 / 6
LEU L  78
LYS L 107
GLN L   6
PHE L  83
1.47A18.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
PHE B 588
LEU B 591
LEU B 595
PRO B 451
1.10A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.38A16.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.39A17.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
PHE A 223
ALA A 267
LEU A 272
ASN A 274
LEU A 271
1.56A24.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.44A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
LEU B 268
LEU D 208
ARG D 217
GLU D 270
1.45A23.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 6
LEU D 106
LYS D  86
GLN D 113
PHE D  75
1.52A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
LEU A  45
LEU A  29
ARG A  39
GLU A  70
1.45A22.22
None
None
PO4  A 124 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B 253
ALA B 210
GLN B 299
ILE B 249
LEU B 250
1.39A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.43A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B 253
ALA B 210
GLN B 299
ILE B 249
LEU B 250
1.43A16.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.43A16.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
ILE D  43
LYS D  61
LEU D  87
LEU D  89
VAL D  77
1.36A24.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.44A16.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 7
LEU A 262
PRO A  62
ARG A 279
ARG A 283
1.46A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3sci ACE2
(Homo
sapiens)		4 / 7
PHE B 588
LEU B 591
LEU B 595
PRO B 451
1.18A12.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE F 345
LYS F 324
ALA F 384
LEU F 499
VAL F 497
1.53A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE E 345
LYS E 324
ALA E 384
LEU E 499
VAL E 497
1.57A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
PHE B 588
LEU B 591
LEU B 595
PRO B 451
1.15A12.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.38A16.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 282
ALA A 210
THR A 257
ASP A 216
LEU A 268
1.51A16.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.44A17.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
LEU A 253
ALA A 210
ASP A 295
HIS A 246
ILE A 249
LEU A 250
1.79A17.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
LEU A 253
ALA A 210
ASP A 295
HIS A 246
ILE A 249
LEU A 250
1.80A17.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.44A17.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		4mm3 UBIQUITIN
(Homo
sapiens)		5 / 10
ILE A  23
LYS A  27
LEU A  50
LEU A  67
VAL A   5
1.38A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 12
ILE A 289
THR A 257
LEU A 284
VAL A 268
PHE A 263
1.40A18.39
None
None
None
None
PO4  A 404 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 6
ASN A 267
LYS A 141
ILE A 152
PHE A 137
1.39A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.40A17.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5c5n 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 282
ALA A 210
ILE A 213
THR A 304
ASP A 216
1.52A18.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
PHE B 514
LEU B 442
LEU B 508
ARG B 310
1.40A13.12
None
None
None
G3A  B 606 (-2.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
PHE B 514
LEU B 442
LEU B 508
ARG B 310
1.21A13.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		6 / 12
VAL B 381
ILE B 510
LEU B 442
VAL B 317
LEU B 321
PHE B 445
1.75A13.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		5e6j POLYUBIQUITIN-B
(synthetic
construct)		5 / 10
ILE F  23
LYS F  27
LEU F  50
LEU F  67
VAL F   5
1.37A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5f22 NSP8
(SARSr-CoV)		4 / 7
PHE B  97
LEU B 100
LEU B 108
PRO B 121
1.22A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		5f22 NSP8
NSP7
(SARSr-CoV)		5 / 10
ARG B 116
ILE B 112
ALA B 115
LEU A  61
LEU A  65
1.47A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 6
ASN D 160
LYS D 200
GLN D 168
PHE D 217
1.16A13.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 10
PHE C 146
ASN C 104
LEU C 117
LEU C 109
VAL C  91
1.59A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		6 / 12
VAL A 381
ILE A 510
LEU A 442
VAL A 317
LEU A 321
PHE A 445
1.75A13.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5r83 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 282
ALA A 210
ILE A 213
ASP A 216
1.51A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5r84 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.40A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 259
LEU A 220
VAL A 261
LEU A 250
PHE A 219
1.78A22.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 250
LEU A 242
ILE A 200
THR A 199
LEU A 253
1.69A22.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.41A22.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
ALA A 210
THR A 257
ASP A 216
LEU A 268
1.71A22.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 282
ALA A 210
ILE A 213
ASP A 216
1.51A22.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  91
LEU A  30
CYH A  16
THR A  98
PHE A 159
1.75A22.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU C1031
ASN C 896
GLN C 902
ILE C 905
0.97A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
TYR A  87
ALA A 146
ILE A 296
ASP A 174
ILE A 300
1.28A17.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ARG A 126
ILE A 125
ALA A 127
LEU A 222
LEU A 224
1.51A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ASN A 122
GLN A 147
ILE A 152
PHE A 130
1.51A17.69
NAG  A 602 (-4.3A)
NAG  A 602 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
ASN B 907
GLN B 915
ILE B 704
PHE B1034
1.54A10.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
TYR B  87
ALA B 146
ILE B 296
ASP B 174
ILE B 300
1.27A6.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
ARG A 126
ILE A 125
ALA A 127
LEU A 222
LEU A 224
1.58A14.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5x5c S PROTEIN
(MERS-CoV)		4 / 7
PHE B 571
LEU B 443
PRO B 430
ARG C1057
1.32A6.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5x5f S PROTEIN
(MERS-CoV)		4 / 6
LEU A 893
ASN A 870
GLN A1003
PHE A1012
1.53A6.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
ILE A 428
THR A 424
VAL A 575
LEU A 441
THR A 574
1.43A6.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		4 / 6
LEU C 948
ASN A 937
GLN C 936
ILE b  11
1.43A24.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ARG B 126
ILE B 125
ALA B 127
LEU B 222
LEU B 224
1.24A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ASN A 122
GLN A 147
ILE A 152
PHE A 130
1.13A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
LEU A 222
LEU A 224
ARG B 449
GLU A  45
1.41A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU A 681
ILE A 656
THR A 631
GLN A 630
ILE C 852
1.20A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
ARG C 126
ILE C 125
ALA C 127
LEU C 222
LEU C 224
1.51A13.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
ASN C 907
GLN C 915
ILE C 704
PHE C1034
1.54A8.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
ARG B 747
ASN B 746
ALA B 748
LEU B 994
VAL B 990
1.26A14.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
LEU B 515
LEU B 374
PRO B 565
ARG B 315
1.35A8.31
None
None
None
NAG  B1306 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
ASN A 122
GLN A 147
ILE A 152
PHE A 130
1.20A8.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU B 377
LEU B 374
ALA B 371
ASP B 351
ILE B 345
1.48A8.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
LEU E 977
ALA F 972
ASP F 979
ILE D 980
LEU D 977
1.47A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 7
LEU A 981
LEU A 977
GLU B 988
ARG C 983
1.40A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 6
LEU F 938
ASN F 928
LYS D 933
ILE E 934
1.45A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.45A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  91
LEU A  30
CYH A  16
THR A  98
PHE A 159
1.76A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 282
ALA A 210
ILE A 213
ASP A 216
1.70A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
ALA A 210
THR A 257
ASP A 216
LEU A 268
1.76A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6lzg ACE2
(Homo
sapiens)		5 / 12
ALA A 304
ILE A 307
THR A 365
ASP A 335
HIS A 345
1.32A13.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m0j ACE2
(Homo
sapiens)		5 / 12
ALA A 304
ILE A 307
THR A 365
ASP A 335
HIS A 345
1.31A12.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  91
LEU A  30
CYH A  16
THR A  98
PHE A 159
1.77A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
ALA A 210
THR A 257
ASP A 216
LEU A 268
1.76A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.43A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 282
ALA A 210
ILE A 213
ASP A 216
1.71A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m17 ACE2
(Homo
sapiens)		4 / 7
PHE B 588
LEU B 591
LEU B 595
PRO B 451
1.24A10.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		6m1d ACE2
(Homo
sapiens)		5 / 12
MET D 706
ARG D 705
ILE D 727
ILE D 711
TYR D 649
1.72A13.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 10
ILE A 545
ALA A 271
LEU A 541
LEU A  77
VAL A 275
1.60A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU D 282
ALA D 210
THR D 257
ASP D 216
LEU D 268
1.70A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.42A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C 282
ALA C 210
THR C 257
ASP C 216
LEU C 268
1.61A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C 114
PHE C 150
THR C 175
LEU C 177
VAL C  13
1.50A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C  91
LEU C  30
CYH C  16
THR C  98
PHE C 159
1.79A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.42A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
LEU C 167
PRO C 132
GLU C 290
ARG C 131
1.77A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 253
ALA A 210
ASP A 295
HIS A 246
LEU A 250
1.60A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B 253
ALA B 210
ASP B 295
HIS B 246
LEU B 250
1.59A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL D  91
LEU D  30
CYH D  16
THR D  98
PHE D 159
1.75A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C 250
LEU C 242
ILE C 200
THR C 199
LEU C 253
1.73A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE A 150
THR A 175
LEU A 177
VAL A  13
LEU A 115
1.52A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
ASN D  72
GLN A 306
ILE A 213
PHE A   3
1.69A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU D 208
LEU D 282
ALA D 210
ILE D 213
ASP D 216
1.61A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C 208
LEU C 282
ALA C 210
ILE C 213
ASP C 216
1.58A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 282
ALA A 210
ILE A 213
ASP A 216
1.65A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 250
LEU A 242
ILE A 200
THR A 199
LEU A 253
1.71A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.43A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  91
LEU A  30
CYH A  16
THR A  98
PHE A 159
1.74A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
ALA A 210
THR A 257
ASP A 216
LEU A 268
1.78A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 134
LEU A 142
LEU A 146
ARG A 173
1.78A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 471
LEU A 731
GLU A 744
ARG A 726
1.58A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6m71 NSP12
(SARS-CoV-2)		5 / 10
ARG A 181
ASN A 150
LEU A 142
LEU A 146
VAL A 147
1.70A16.61

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 165
LEU A 172
PRO A 627
ARG A 349
1.60A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
MET A 380
ALA A 379
ILE A 333
ILE B 107
TYR A 273
1.75A12.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP8
(SARS-CoV-2)		4 / 7
PHE D  92
LEU D  95
LEU D 103
PRO D 116
1.32A23.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		4 / 7
LEU A 575
ARG A 654
GLU A 474
ARG A 640
1.59A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		6 / 12
MET A 124
ALA A 125
ILE A 145
ILE A 244
TYR A 788
HIS A 133
1.70A12.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		4 / 7
LEU A 469
LEU A 308
ARG A 651
ARG A 631
1.56A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6m71 NSP12
(SARS-CoV-2)		5 / 10
ILE A 632
ASN A 790
LEU A 308
ASN A 312
LEU A 469
1.23A16.61

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
THR A 701
LEU A 469
CYH A 464
LEU A 247
THR A 462
1.77A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 514
ALA A 512
ILE A 562
GLN A 524
MET A 519
1.62A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A  34
ILE A 145
ILE A 244
TYR A 788
HIS A 133
1.63A12.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 745
LEU A 707
LEU A 708
ARG A 733
1.75A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 348
LEU A 329
PRO A 323
ARG A 349
1.66A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 708
LEU A 240
ASP A  36
HIS A 725
LEU A 727
1.77A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 512
ILE A 562
GLN A 524
MET A 519
ASP A 517
1.77A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6m71 NSP12
(SARS-CoV-2)		5 / 10
ILE A 632
ASN A 691
ALA A 690
LEU A 636
VAL A 693
1.79A16.61

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 471
LEU A 708
GLU A 744
ARG A 726
1.40A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 638
THR A 643
ASP A 477
ILE A 579
LEU A 576
1.72A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
PHE A 340
ILE A 333
THR A 344
VAL A 335
LEU A 366
1.53A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 317
LEU A 316
PRO A 322
GLU A 278
1.77A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		4 / 7
PHE A 419
LEU A 838
LEU A 437
ARG A 858
1.69A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ILE A  86
THR A  85
LEU A  89
VAL A 202
THR A 225
1.59A9.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE B 800
ALA B1038
LEU B 920
LEU B 927
VAL B 708
1.39A13.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6nur NSP12
(SARSr-CoV)		5 / 10
ILE A 632
ASN A 790
LEU A 308
ASN A 312
LEU A 469
1.47A16.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6nur NSP8
(SARSr-CoV)		4 / 7
PHE D  92
LEU D  95
LEU D 103
PRO D 116
1.16A23.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6nur NSP12
(SARSr-CoV)		5 / 12
PHE A 340
ILE A 333
THR A 344
VAL A 335
LEU A 366
1.38A8.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		6nus NSP12
NSP8
(SARSr-CoV)		5 / 12
MET B  87
ALA B  86
ARG B  80
SER A 518
ILE A 562
1.36A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		6nus NSP12
(SARSr-CoV)		6 / 12
MET A 124
ALA A 125
ILE A 145
ILE A 244
TYR A 788
HIS A 133
1.62A12.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6nus NSP12
(SARSr-CoV)		4 / 7
PHE A 275
LEU A 282
PRO A 461
ARG A 349
1.23A8.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE B 201
LEU B 117
PRO A 521
ARG A 357
1.45A8.37
None
None
None
NAG  B1318 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU B 878
ASN B 928
GLN B 935
ILE B 818
1.02A8.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
THR A 240
LEU A  84
VAL A  62
LEU A 216
PHE A  65
1.39A8.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
ARG C 765
ASN C 764
ALA C 766
LEU C1012
VAL C1008
1.44A13.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6vw1 ACE2
(Homo
sapiens)		4 / 7
PHE B 588
LEU B 591
LEU B 595
PRO B 451
1.18A13.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE B 281
LEU B 246
CYH B 293
VAL B 295
LEU B 252
1.26A17.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6vxs NSP3
(SARS-CoV-2)		4 / 6
LEU B 140
ASN B 159
ILE B  18
PHE B 168
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6vxs NSP3
(SARS-CoV-2)		5 / 12
THR B  57
LEU B  88
CYH B  92
LEU B  43
HIS B  45
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6vxs NSP3
(SARS-CoV-2)		5 / 10
ARG B 148
ASN B  15
LEU B  93
LEU B 122
VAL B 151
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL B  36
PHE B 116
THR B  33
VAL B 147
THR B 149
1.79A
None
None
NHE  B 203 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL B  35
LYS B  44
LEU B  43
CYH B  81
VAL B  82
1.58A
None
SO4  A 201 ( 4.4A)
None
None
NHE  B 203 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6vxs NSP3
(SARS-CoV-2)		4 / 6
LEU A 140
ASN A 159
ILE A  18
PHE A 168
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL A  35
LYS A  44
LEU A  43
CYH A  81
VAL A  82
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU C 117
ASN C 122
ILE C 105
PHE C 106
1.42A8.39
None
NAG  C1302 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
ARG B 765
ASN B 764
ALA B 766
LEU B1012
VAL B1008
1.38A13.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU B 117
ASN B 122
ILE B 105
PHE B 106
1.45A8.39
None
NAG  B1302 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
ARG B 765
ASN B 764
ALA B 766
LEU B1012
VAL B1008
1.37A13.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ILE B  97
ASN B  83
LEU B  50
LEU B  58
VAL B 102
1.39A23.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w02 NSP3
(SARS-CoV-2)		5 / 12
LEU B 126
LEU B 127
THR B 146
ILE B  18
LEU B 164
1.48A20.36
APR  B 201 (-4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
TYR L  86
ALA L  84
GLN L  42
ILE L  48
LEU L  73
1.52A22.16
None
None
SO4  L 302 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
LEU L  47
ILE L  21
THR L 102
ASP L  82
LEU L  46
1.73A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 10
ILE C 434
PHE C 464
ALA C 397
LEU C 368
VAL C 395
1.71A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
LEU L  78
ALA L  19
ILE L  21
THR L 102
ASP L  82
1.66A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 6
LEU C 513
ASN C 343
ILE C 358
PHE C 515
1.54A18.08
None
NAG  C 601 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6925
VAL A6865
LEU A6883
PHE A6868
HIS A6867
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6848
LEU A6852
PRO A6888
ARG A7053
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A7060
PRO A6860
ARG A7077
ARG A7081
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE A6985
LEU A6855
GLU A7015
ARG A7014
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6924
LEU A6848
THR A6989
ILE A6955
LEU A6959
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6825
ALA A6997
ILE A7035
GLN A7036
ASP A6830
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
PHE A 150
THR A 175
LEU A 177
VAL A  13
LEU A 115
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 250
LEU A 242
ILE A 200
THR A 199
LEU A 253
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 282
ALA A 210
ILE A 213
ASP A 216
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
ALA A 210
THR A 257
ASP A 216
LEU A 268
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
PHE A 230
LEU A 268
LEU A 208
ARG A 279
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  35
LYS A  44
LEU A  43
CYH A  81
VAL A  82
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 127
CYH B 143
VAL B 144
LEU B  12
PHE B 116
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  36
PHE A 116
THR A  33
VAL A 147
THR A 149
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  35
LYS B  44
LEU B  43
CYH B  81
VAL B  82
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU C6848
LYS C6968
GLN C6801
PHE C7003
1.76A23.60
None
FMT  C7108 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU A6848
LYS A6968
GLN A6801
PHE A7003
1.75A23.60
None
FMT  A7104 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6825
ALA A6997
ILE A7035
GLN A7036
ASP A6830
1.65A23.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE C6985
LEU C6855
GLU C7015
ARG C7014
1.54A23.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE A6925
VAL A6865
LEU A6883
PHE A6868
HIS A6867
1.69A23.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A6961
LEU A7073
ARG A7053
ARG A6864
1.59A23.60
None
None
None
FMT  A7106 ( 2.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ILE A6838
ASN A6996
ALA A6843
LEU A7042
VAL A6995
1.69A22.07
None
FMT  A7104 ( 3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU C7060
PRO C6860
ARG C7077
ARG C7081
1.43A23.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A7060
PRO A6860
ARG A7077
ARG A7081
1.59A23.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w75 NSP16
(SARS-CoV-2)		4 / 7
LEU A6848
LEU A6852
PRO A6888
ARG A7053
1.60A23.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w75 NSP16
(SARS-CoV-2)		4 / 7
PHE C6985
LEU C6857
GLU C7015
ARG C7014
1.62A23.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 7
PHE A7043
LEU A7042
PRO B4312
GLU B4319
1.60A23.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ILE C6838
ASN C6996
ALA C6843
LEU C7042
VAL C6995
1.68A22.07
None
FMT  C7108 ( 3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6825
ALA C6997
ILE C7035
GLN C7036
ASP C6830
1.69A23.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
TYR B 136
ALA B 139
GLN B  97
ILE B 123
LEU B 125
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 10
ASN B  88
ALA B  86
LEU B 113
ASN B 110
VAL B 159
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 136
ALA A 139
GLN A  97
ILE A 123
LEU A 125
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
TYR C  83
LEU C 150
THR C  10
ASP C 134
HIS C  73
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
TYR B  83
LEU B 150
THR B  10
ASP B 134
HIS B  73
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
PHE C 147
LEU C 132
GLU C 143
ARG C 138
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
TYR C 136
ALA C 139
GLN C  97
ILE C 123
LEU C 125
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
LEU A  44
ALA A  15
THR A  64
ILE A  91
LEU A  69
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 7
PHE A  56
LEU A  44
LEU A  51
ARG A  55
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 7
PHE A  56
LEU A  44
LEU A  69
ARG A  55
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A  35
LYS A  44
LEU A  43
CYH A  81
VAL A  82
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wcf NSP3
(SARS-CoV-2)		4 / 6
LEU A 140
ASN A 159
ILE A  18
PHE A 168
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wen NSP3
(SARS-CoV-2)		4 / 7
PHE A 116
LEU A 126
ARG A 141
GLU A 114
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A  35
LYS A  44
LEU A  43
CYH A  81
VAL A  82
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wey NSP3
(SARS-CoV-2)		4 / 7
LEU A 214
LEU A 216
PRO A 340
ARG A 345
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 330
ALA A 333
ASP A 339
ILE A 222
LEU A 357
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 330
ALA A 358
ASP A 361
ILE A 341
LEU A 344
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 10
ARG B 111
ILE B 107
ALA B 110
LEU A  56
LEU A  60
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wiq NSP8
(SARS-CoV-2)		4 / 7
PHE B  92
LEU B  95
LEU B 103
PRO B 116
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 7
PHE B  92
LEU B  91
LEU A  13
PRO B 116
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 10
ARG B 111
ILE B 107
LEU A  56
LEU A  59
VAL A  66
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU B  91
LEU A  20
MET A  62
ILE B 107
LEU B  95
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wiq NSP8
(SARS-CoV-2)		5 / 12
LEU B 128
LEU B 189
ALA B 188
ILE B 156
GLN B 158
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
LEU A 353
LEU B 331
PRO B 258
ARG B 259
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU C 339
ASN C 285
ILE C 337
PHE C 307
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
LEU E 353
LEU F 331
PRO F 258
ARG F 259
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
LEU D 353
LEU C 331
PRO C 258
ARG C 259
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
LEU B 353
LEU A 331
PRO A 258
ARG A 259
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
LEU F 353
LEU E 331
PRO E 258
ARG E 259
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU F 339
ASN F 285
ILE F 337
PHE F 307
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
LEU C 353
LEU D 331
PRO D 258
ARG D 259
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU A 339
ASN A 285
ILE A 337
PHE A 307
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU D 339
ASN D 285
ILE D 337
PHE D 307
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU B 339
ASN B 285
ILE B 337
PHE B 307
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU E 339
ASN E 285
ILE E 337
PHE E 307
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
ILE F 304
PHE F 274
ALA F 308
LEU F 353
LEU E 331
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE C6985
LEU C6857
GLU C7015
ARG C7014
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU C6848
LYS C6968
GLN C6801
PHE C7003
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6848
ASN A7008
ILE A6926
PHE A7003
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6848
LEU A6852
PRO A6888
ARG A7053
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6825
ALA A6997
ILE A7035
GLN A7036
ASP A6830
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU C7060
PRO C6860
ARG C7077
ARG C7081
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6924
LEU C6848
THR C6989
ILE C6955
LEU C6959
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE C6925
VAL C6865
LEU C6883
PHE C6868
HIS C6867
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6961
LEU A7073
ARG A7053
ARG A6864
1.61A
None
None
None
FMT  A7106 (-2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU C6848
ASN C7008
ILE C6926
PHE C7003
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ILE A6838
ASN A6996
ALA A6843
LEU A7042
VAL A6995
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ILE C6838
ASN C6996
ALA C6843
LEU C7042
VAL C6995
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE C6985
LEU C6855
GLU C7015
ARG C7014
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6825
ALA C6997
ILE C7035
GLN C7036
ASP C6830
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6924
LEU C6848
THR C6989
ILE C6955
LEU C6959
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6825
ALA C6997
ILE C7035
GLN C7036
ASP C6830
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6wkq NSP16
(SARS-CoV-2)		5 / 10
ILE A6838
ASN A6996
ALA A6843
LEU A7042
VAL A6995
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU C6848
ASN C7008
ILE C6926
PHE C7003
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU A6848
LYS A6968
GLN A6801
PHE A7003
1.80A
None
SFG  A7103 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wkq NSP16
(SARS-CoV-2)		4 / 7
LEU A6848
LEU A6852
PRO A6888
ARG A7053
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wkq NSP16
(SARS-CoV-2)		4 / 7
LEU C7060
PRO C6860
ARG C7077
ARG C7081
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wkq NSP16
(SARS-CoV-2)		4 / 7
LEU A7060
PRO A6860
ARG A7077
ARG A7081
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 7
PHE A7043
LEU A7042
PRO B4312
GLU B4319
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wkq NSP16
(SARS-CoV-2)		4 / 7
PHE C6985
LEU C6857
GLU C7015
ARG C7014
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6wkq NSP16
(SARS-CoV-2)		5 / 10
ILE C6838
ASN C6996
ALA C6843
LEU C7042
VAL C6995
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wkq NSP16
(SARS-CoV-2)		4 / 7
LEU A6961
LEU A7073
ARG A7053
ARG A6864
1.60A
None
None
None
FMT  A7109 ( 2.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6825
ALA A6997
ILE A7035
GLN A7036
ASP A6830
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wkq NSP16
(SARS-CoV-2)		4 / 7
PHE C6985
LEU C6855
GLU C7015
ARG C7014
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU C6848
LYS C6968
GLN C6801
PHE C7003
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE B 259
LEU B 201
LEU B 252
ARG B 258
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A 251
GLN A 347
ILE A 296
PHE A 303
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PHE B 233
ILE B 307
VAL B 237
LEU B 300
PHE B 330
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE B 123
LEU B  73
LEU B  76
GLU B 146
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PHE A 123
LEU A  73
LEU A  76
GLU A 146
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ILE B  97
ASN B  83
LEU B  50
LEU B  58
VAL B 102
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A 281
LEU A 246
CYH A 293
VAL A 295
LEU A 252
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE B 281
LEU B 246
CYH B 293
VAL B 295
LEU B 252
1.36A
None
None
U5P  B 401 (-4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A 281
LEU A 246
VAL A 295
LEU A 252
PHE A 241
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
LEU B 163
LEU B 168
PRO B 158
ARG B 207
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PHE A 233
ILE A 307
VAL A 237
LEU A 300
PHE A 330
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B 237
PHE B 233
ILE B 223
VAL B 304
LEU B 300
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE B 281
LEU B 246
VAL B 295
LEU B 252
PHE B 241
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL A 237
PHE A 233
ILE A 223
VAL A 304
LEU A 300
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ILE A  97
ASN A  83
LEU A  50
LEU A  58
VAL A 102
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 250
LEU A 242
ILE A 200
THR A 199
LEU A 253
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
ALA A 210
THR A 257
ASP A 216
LEU A 268
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 282
ALA A 210
ILE A 213
ASP A 216
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B  36
PHE B 116
VAL B 147
THR B 149
PHE C 156
1.71A
None
None
None
None
APR  C 201 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 126
LEU A 127
THR A 146
ILE A  18
LEU A 164
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 126
LEU B 127
THR B 146
ILE B  18
LEU B 164
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B  35
LYS B  44
LEU B  43
CYH B  81
VAL B  82
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  36
PHE A 116
THR A  33
VAL A 147
THR A 149
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D 126
LEU D 127
THR D 146
ILE D  18
LEU D 164
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C  35
LYS C  44
LEU C  43
CYH C  81
VAL C  82
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 127
CYH B 143
VAL B 144
LEU B  12
PHE B 116
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 127
CYH A 143
VAL A 144
LEU A  12
PHE A 116
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 126
LEU C 127
THR C 146
ILE C  18
LEU C 164
1.46A
APR  C 201 (-4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D  36
PHE D 116
VAL D 147
THR D 149
PHE A 156
1.72A
None
None
None
None
APR  A 201 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6848
LYS A6968
GLN A6801
PHE A7003
1.74A
None
GTA  A7102 (-3.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6924
LEU A6848
THR A6989
ILE A6955
LEU A6959
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6848
LEU A6852
PRO A6888
ARG A7053
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6925
VAL A6865
LEU A6883
PHE A6868
HIS A6867
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 7
PHE A7043
LEU A7042
PRO B4312
GLU B4319
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A7060
PRO A6860
ARG A7077
ARG A7081
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
LEU A6961
LEU A7073
ARG A7053
ARG A6864
1.62A
None
None
None
SO4  A7106 (-3.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
PHE A6985
LEU A6855
GLU A7015
ARG A7014
1.67A
None
8NK  A7103 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6848
ASN A7008
ILE A6926
PHE A7003
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
ARG D 111
ILE D 107
ASN C  69
LEU D  95
LEU D  91
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
PHE D  92
LEU C  13
LEU C  55
PRO D 116
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
PHE B  92
LEU A  13
LEU A  55
PRO B 116
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
ARG D 111
ILE D 107
ALA D 110
LEU C  56
LEU C  60
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
PHE D  92
LEU D  91
LEU C  13
PRO D 116
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
PHE B  92
LEU B  91
LEU A  13
PRO B 116
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wqd NSP8
(SARS-CoV-2)		4 / 7
PHE B  92
LEU B  95
LEU B 103
PRO B 116
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wqd NSP8
(SARS-CoV-2)		4 / 7
PHE D  92
LEU D  95
LEU D 103
PRO D 116
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
ARG B 111
ALA B 110
LEU A  59
LEU A  60
VAL B 115
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
ARG D 111
ILE D 107
LEU C  56
LEU C  60
VAL C  66
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 282
ALA A 210
ILE A 213
ASP A 216
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 259
LEU A 220
VAL A 261
LEU A 250
PHE A 219
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 250
LEU A 242
ILE A 200
THR A 199
LEU A 253
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
TYR A 136
ALA A 139
GLN A  97
ILE A 123
LEU A 125
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 10
ASN A  88
ALA A  86
LEU A 113
ASN A 110
VAL A 159
1.75A
GOL  A 507 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6xdc PROTEIN 3A
(SARS-CoV-2)		4 / 6
ASN A 144
GLN B 185
ILE B 158
PHE B 146
1.30A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6xdc PROTEIN 3A
(SARS-CoV-2)		4 / 6
ASN B 144
GLN A 185
ILE A 158
PHE A 146
1.29A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 250
LEU A 242
ILE A 200
THR A 199
LEU A 253
1.67A22.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 282
ALA A 210
THR A 257
ASP A 216
LEU A 268
1.71A22.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  91
LEU A  30
CYH A  16
THR A  98
PHE A 159
1.75A22.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 282
ALA A 210
ILE A 213
ASP A 216
1.52A22.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.41A22.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
THR C  45
MET C   3
ASP C   5
HIS C  36
LEU C  13
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
PHE B  92
LEU A  56
LEU B 103
ARG B 111
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
PHE B  92
LEU B  91
LEU A  13
PRO B 116
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
PHE D  92
LEU D  91
LEU C  13
PRO D 116
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
LEU C  13
LEU D  91
PRO D 116
ARG D 111
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 10
ARG B  96
LYS A  70
ASN B 108
LEU A  59
LEU A  60
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
PHE D  92
LEU C  13
LEU C  55
PRO D 116
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
PHE B  92
LEU A  13
LEU A  55
PRO B 116
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
PHE D  92
LEU D  95
LEU D 103
PRO D 116
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
PHE B  92
LEU B  95
LEU B 103
PRO B 116
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 7
PHE A  13
LEU A 119
LEU A  16
ARG A  49
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 7
PHE A 131
LEU A  24
GLU A 134
ARG A  67
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU L  84
ALA L  19
ILE L  21
THR L 108
ASP L  88
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
ILE A 434
PHE A 464
ALA A 397
LEU A 368
VAL A 395
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU C  84
ALA C  19
ILE C  21
THR C 108
ASP C  88
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR L  92
ALA L  90
GLN L  48
ILE L  54
LEU L  79
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR C  92
ALA C  90
GLN C  48
ILE C  54
LEU C  79
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
VAL A 395
PHE A 515
ILE C  34
VAL A 382
LEU A 387
1.75A
None
None
None
DMS  A 905 (-4.3A)
DMS  A 905 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE A 490
LEU A 492
LEU A 452
ARG A 346
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR L  92
ALA L  90
GLN L  48
ILE L  54
LEU L  79
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
ILE E 358
ASN E 354
ALA E 397
LEU E 513
VAL E 511
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PHE E 392
LEU E 517
LEU E 518
PRO E 426
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU L  84
ALA L  19
ILE L  21
THR L 108
ASP L  88
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ym0 LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
VAL E 395
PHE E 515
ILE L  34
VAL E 382
LEU E 387
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 253
ALA A 210
ASP A 295
HIS A 246
LEU A 250
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 282
ALA A 210
ILE A 213
ASP A 216
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A  66
THR A  25
LEU A  27
CYH A  38
LEU A  58
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  91
LEU A  30
CYH A  16
THR A  98
PHE A 159
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 250
LEU A 242
ILE A 200
THR A 199
LEU A 253
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
ILE E 434
PHE E 464
ALA E 397
LEU E 368
VAL E 395
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
TYR L  92
ALA L  90
GLN L  48
ILE L  54
LEU L  79
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
LEU C  84
ALA C  19
ILE C  21
THR C 108
ASP C  88
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
TYR C  92
ALA C  90
GLN C  48
ILE C  54
LEU C  79
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
LEU L  84
ALA L  19
ILE L  21
THR L 108
ASP L  88
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 250
LEU A 242
ILE A 200
THR A 199
LEU A 253
1.67A
None
None
PEG  A 405 (-4.1A)
PEG  A 404 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 282
ALA A 210
ILE A 213
ASP A 216
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 259
LEU A 220
VAL A 261
LEU A 250
PHE A 219
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  91
LEU A  30
CYH A  16
THR A  98
PHE A 159
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ILE B  23
PHE B 132
ASN E 101
ALA B  52
LEU B  88
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 126
LEU C 127
THR C 146
ILE C  18
LEU C 164
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  35
LYS A  44
LEU A  43
CYH A  81
VAL A  82
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 127
CYH A 143
VAL A 144
LEU A  12
PHE A 116
1.77A
EDO  A 202 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  35
LYS B  44
LEU B  43
CYH B  81
VAL B  82
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 126
LEU B 127
THR B 146
ILE B  18
LEU B 164
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  36
PHE C 116
THR C  33
VAL C 147
THR C 149
1.78A
None
None
EDO  C 207 ( 4.8A)
None
EDO  C 206 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  35
LYS C  44
LEU C  43
CYH C  81
VAL C  82
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 126
LEU A 127
THR A 146
ILE A  18
LEU A 164
1.48A
None
EDO  A 202 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 126
LEU C 127
THR C 146
ILE C  18
LEU C 164
1.43A
APR  C 201 (-4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 126
LEU A 127
THR A 146
ILE A  18
LEU A 164
1.43A
APR  A 201 (-4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  36
PHE B 116
THR B  33
VAL B 147
THR B 149
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  36
PHE A 116
THR A  33
VAL A 147
THR A 149
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  35
LYS B  44
LEU B  43
CYH B  81
VAL B  82
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  36
PHE C 116
THR C  33
VAL C 147
THR C 149
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 126
LEU D 127
THR D 146
ILE D  18
LEU D 164
1.42A
APR  D 201 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 127
CYH A 143
VAL A 144
LEU A  12
PHE A 116
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 126
LEU B 127
THR B 146
ILE B  18
LEU B 164
1.41A
APR  B 201 (-4.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  35
LYS D  44
LEU D  43
CYH D  81
VAL D  82
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  35
LYS A  44
LEU A  43
CYH A  81
VAL A  82
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  35
LYS E  44
LEU E  43
CYH E  81
VAL E  82
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  35
LYS C  44
LEU C  43
CYH C  81
VAL C  82
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  36
PHE D 116
THR D  33
VAL D 147
THR D 149
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
PHE B 168
LEU B  12
PRO B 136
GLU A  25
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 126
LEU A 127
THR A 146
ILE A  18
LEU A 164
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 127
CYH C 143
VAL C 144
LEU C  12
PHE C 116
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  35
LYS A  44
LEU A  43
CYH A  81
VAL A  82
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  36
PHE C 116
THR C  33
VAL C 147
THR C 149
1.79A
None
None
None
None
EDO  C 204 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 127
CYH A 143
VAL A 144
LEU A  12
PHE A 116
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
ALA A 210
THR A 257
ASP A 216
LEU A 268
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  91
LEU A  30
CYH A  16
THR A  98
PHE A 159
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 250
LEU A 242
ILE A 200
THR A 199
LEU A 253
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 282
ALA A 210
ILE A 213
ASP A 216
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 340
ILE A 333
THR A 344
VAL A 335
LEU A 366
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 10
ARG D 111
ILE D 107
ALA D 110
LEU C  56
LEU C  60
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 419
LEU A 838
LEU A 437
ARG A 858
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		5 / 12
THR A 701
LEU A 469
CYH A 464
LEU A 247
THR A 462
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 7
PHE A 340
LEU B  95
LEU B  98
PRO A 378
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		5 / 12
TYR A 516
LEU A 498
ALA A 512
ILE A 562
ILE A 494
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		7btf NSP12
(SARS-CoV-2)		6 / 12
MET A 124
ALA A 125
ILE A 145
ILE A 244
TYR A 788
HIS A 133
1.75A12.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 317
LEU A 316
PRO A 322
GLU A 278
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 340
ILE A 333
THR A 344
LEU A 361
LEU A 366
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 275
LEU A 282
PRO A 461
ARG A 349
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		7btf NSP12
(SARS-CoV-2)		5 / 10
ILE A 632
ASN A 790
LEU A 308
ASN A 312
LEU A 469
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 514
ALA A 502
ILE A 562
THR A 565
ASP A 499
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A  34
ILE A 145
ILE A 244
TYR A 788
HIS A 133
1.64A12.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP8
(SARS-CoV-2)		4 / 7
PHE D  92
LEU D  95
LEU D 103
PRO D 116
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 7
PHE A 340
LEU B  95
LEU B  98
PRO A 505
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 745
LEU A 707
LEU A 708
ARG A 733
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		7btf NSP12
(SARS-CoV-2)		5 / 10
ARG A 181
ASN A 150
LEU A 142
LEU A 146
VAL A 147
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 575
ARG A 654
GLU A 474
ARG A 640
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 514
ALA A 512
ILE A 562
GLN A 524
MET A 519
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 638
THR A 643
ASP A 477
ILE A 579
LEU A 576
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 471
LEU A 708
GLU A 744
ARG A 726
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 708
LEU A 240
ASP A  36
HIS A 725
LEU A 727
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 7
PHE D  92
LEU D  91
LEU C  13
PRO D 116
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 469
LEU A 308
ARG A 651
ARG A 631
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		7btf NSP12
(SARS-CoV-2)		5 / 10
ILE A 632
ASN A 691
ALA A 690
LEU A 636
VAL A 693
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 165
LEU A 172
PRO A 627
ARG A 349
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
TYR A 374
LEU A 366
ILE A 333
ASP A 336
LEU B  91
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 348
LEU A 329
PRO A 323
ARG A 349
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 7
LEU C  56
LEU C  60
PRO D 121
GLU C  50
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 134
LEU A 142
LEU A 146
ARG A 173
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		4 / 6
ASN A  79
LYS A  50
ILE A  37
PHE A  35
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7btf NSP12
(SARS-CoV-2)		4 / 7
PHE A 471
LEU A 731
GLU A 744
ARG A 726
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
ALA A 210
ILE A 213
THR A 304
ASP A 216
1.73A
DMS  A 404 (-4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
ALA A 210
THR A 257
ASP A 216
LEU A 268
1.72A
DMS  A 404 (-4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  91
LEU A  30
CYH A  16
THR A  98
PHE A 159
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 282
ALA A 210
ILE A 213
ASP A 216
1.68A
None
DMS  A 404 (-4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 638
THR A 643
ASP A 477
ILE A 579
LEU A 576
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 419
LEU A 838
LEU A 437
ARG A 858
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP8
(SARS-CoV-2)		5 / 12
LEU D 128
LEU D 189
ALA D 188
ILE D 156
GLN D 158
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
MET A 124
ALA A 125
ILE A 145
ILE A 244
TYR A 788
1.55A12.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 317
LEU A 316
PRO A 322
GLU A 278
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
PHE A 340
ILE A 333
THR A 344
VAL A 335
LEU A 366
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
ILE A 632
ASN A 790
LEU A 308
ASN A 312
LEU A 469
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
ARG A 181
ASN A 150
LEU A 142
LEU A 146
VAL A 147
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
MET A 519
SER A 561
ILE A 562
ILE A 536
HIS A 381
1.71A12.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
MET A 124
ILE A 145
ILE A 244
TYR A 788
HIS A 133
1.79A12.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
LEU A 575
ARG A 654
GLU A 474
ARG A 640
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
ILE A 632
ASN A 691
ALA A 690
LEU A 636
VAL A 693
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 308
THR A 701
GLN A 468
ILE A 632
LEU A 636
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 165
LEU A 172
PRO A 627
ARG A 349
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 275
LEU A 282
PRO A 461
ARG A 349
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A  34
ILE A 145
ILE A 244
TYR A 788
HIS A 133
1.61A12.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 7
PHE D  92
LEU D  91
LEU C  13
PRO D 116
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 372
ASN A 657
ILE A 562
PHE A 506
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  13
LEU C  17
ILE D 119
ILE D 107
LEU D 103
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
TYR A 374
LEU A 366
ILE A 333
ASP A 336
LEU B  91
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
THR A 701
LEU A 469
CYH A 464
LEU A 247
THR A 462
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
MET A 380
ALA A 379
ILE A 333
ILE B 107
TYR A 273
1.80A12.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
LEU A 245
LEU A 316
ARG A 279
ARG A 285
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
PHE A 348
LEU A 329
PRO A 323
ARG A 349
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP8
(SARS-CoV-2)		4 / 7
PHE D  92
LEU D  95
LEU D 103
PRO D 116
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 708
LEU A 240
ASP A  36
HIS A 725
LEU A 727
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 512
ILE A 562
GLN A 524
MET A 519
ASP A 517
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
ILE A 632
ASN A 790
LEU A 308
ASN A 312
LEU A 469
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 638
THR A 643
ASP A 477
ILE A 579
LEU A 576
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
ASN A 781
ALA A 702
LEU A 630
ASN A 790
VAL A 785
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		6 / 12
MET A 124
ALA A 125
ILE A 145
ILE A 244
TYR A 788
HIS A 133
1.77A12.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
ARG A 181
ASN A 150
LEU A 142
LEU A 146
VAL A 147
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 372
ASN A 657
ILE A 562
PHE A 506
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
PHE A 340
ILE A 333
THR A 344
VAL A 335
LEU A 366
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
ILE A 715
ASN A  39
ALA A  43
LEU A 707
LEU A 708
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 498
ALA A 512
ILE A 562
GLN A 524
ASP A 517
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
PHE A 275
LEU A 282
PRO A 461
ARG A 349
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 245
LEU A 316
ARG A 279
ARG A 285
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
PHE A 348
LEU A 329
PRO A 323
ARG A 349
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 512
ILE A 562
GLN A 524
MET A 519
ASP A 517
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 708
LEU A 240
ASP A  36
HIS A 725
LEU A 727
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
PHE A 317
LEU A 316
PRO A 322
GLU A 278
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
PHE A 165
LEU A 172
PRO A 627
ARG A 349
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
TYR A 516
LEU A 498
ALA A 512
ILE A 562
ILE A 494
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A  34
ILE A 145
ILE A 244
TYR A 788
HIS A 133
1.62A12.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
PHE A 419
LEU A 838
LEU A 437
ARG A 858
1.50A
None
None
None
U  P  17 ( 3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
VAL C  12
LYS A 438
LEU A 437
CYH A 842
PHE A 429
1.76A
None