Ligand ID: JN3


Drugbank ID:
DB01586
(Ursodeoxycholic acid)


Indication:
The drug reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want an alternative to surgery.

Get human targets for JN3 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'JN3' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
LEU A 253
ALA A 210
GLN A 299
ILE A 249
LEU A 250
1.40A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.43A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
PHE A  56
LEU A  44
LEU A  69
ARG A  55
1.38A23.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.33A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		1uk4 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 253
ALA A 210
GLN A 299
ILE A 249
LEU A 250
1.37A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE B1153
LYS B1150
ALA B1155
LEU A 944
LEU B 941
1.48A17.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU E 920
ASN D1168
GLN F 915
ILE F 916
1.30A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		5 / 12
TYR A  85
LEU A  81
ALA A 140
ASP A 116
HIS B  31
1.46A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 10
PHE B1223
ASN B1221
ALA B1267
LEU B1272
ASN B1274
LEU B1271
1.57A24.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU J  19
ASN H  20
LYS J  14
GLN I  31
1.55A14.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU C  20
ASN F  20
GLN E  15
ILE E  16
1.20A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		1zvb E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU C  20
ALA B  15
ASP B  22
ILE A  23
LEU A  20
1.43A15.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
LEU B 253
ALA B 210
GLN B 299
ILE B 249
LEU B 250
1.40A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		6 / 12
VAL D 346
LEU D 309
CYH D 325
VAL D 326
LEU D 194
PHE D 298
1.74A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 10
ARG H 116
ILE H 112
ALA H 115
LEU D  61
LEU D  65
1.38A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		4 / 7
PHE H  97
LEU H 100
LEU H 108
PRO H 121
1.21A23.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ajf ACE2
(Homo
sapiens)		4 / 6
ASN A 322
GLN A 305
ILE A 307
PHE A 369
1.55A13.20
NAG  A1322 (-1.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
LEU B 253
ALA B 210
ASP B 295
HIS B 246
ILE B 249
LEU B 250
1.79A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU B 920
ASN F1169
GLN C 915
ILE C 916
1.13A15.45
None
None
None
ACE  C 913 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE C 916
LYS C 914
ASN E1169
LEU E1179
ASN E1176
1.48A9.22
ACE  C 913 ( 4.1A)
ACE  C 913 ( 3.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2bx3 MAIN PROTEINASE
(SARS-COV
Sin2774)		4 / 7
PHE A 230
LEU A 205
LEU A 250
GLU A 270
1.42A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
MET D 323
ILE C 305
ILE C 338
TYR C 334
HIS D 335
1.77A21.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 12
LEU A  47
LEU A  15
GLN A  21
ASP A  17
LEU A  53
1.37A21.14
None
None
None
None
D10  B1099 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 7
PHE D  92
LEU D  88
LEU D  82
PRO D  11
ARG D  48
1.67A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 12
LEU D  47
LEU D  15
GLN D  21
ASP D  17
LEU D  53
1.37A19.35
None
None
None
None
D10  C1099 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PHE A 230
LEU A 205
LEU A 250
GLU A 270
1.44A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.40A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU S 499
ASN S 330
ILE S 345
PHE S 501
1.55A21.00
None
NAG  S1330 (-1.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
PHE C  80
LEU C  81
LEU C  59
PRO B  34
1.38A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
LYS B  93
PHE B  96
ASN B 111
ASN B  89
VAL B 160
1.51A22.58
None
None
None
None
BR  B 319 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		2fxp SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ALA B  34
LEU C  41
ASN C  38
LEU C  37
VAL C  33
1.34A13.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU E 499
ASN E 330
ILE E 345
PHE E 379
1.30A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		4 / 6
LEU D 210
LYS D 239
GLN D 138
PHE D 215
1.36A18.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		4 / 7
LEU D 153
PRO D 191
GLU D 211
ARG D 193
1.23A18.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PHE A 230
LEU A 205
LEU A 250
GLU A 270
1.38A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU A 122
ALA A  80
ILE A  99
GLN A 130
HIS A  14
1.45A15.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2jzf REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU A 627
ALA A 629
HIS A 539
ILE A 525
LEU A 526
1.48A24.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		5 / 10
ASN A  29
ALA A  33
LEU A 105
LEU A  25
VAL A  52
1.14A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		4 / 6
LEU A  58
LYS A  83
GLN A   5
ILE A   7
1.45A23.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2kys NSP7
(SARSr-CoV)		5 / 12
LEU A  61
LEU A  22
ALA A  67
HIS A  38
LEU A  57
1.52A22.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		4 / 7
PHE A 172
LEU A 162
GLU A  64
ARG A  66
1.44A20.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.41A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
LEU B 253
ALA B 210
GLN B 299
ILE B 249
LEU B 250
1.46A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU A 245
ILE A 280
THR A 281
ASP B  36
ILE A 269
1.48A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
THR D  47
LEU D  49
VAL D 101
THR D  98
HIS D  95
1.44A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.41A17.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
LEU A 253
ALA A 210
GLN A 299
ILE A 249
LEU A 250
1.45A15.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.44A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU F 122
ALA F  80
ILE F  99
GLN F 130
HIS F  14
1.41A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
PHE A  55
LEU A   2
LEU E   2
GLU A  41
1.42A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.41A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 10
PHE B 140
ASN A 214
ALA A 211
LEU A 287
LEU A 208
1.38A22.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2wct NSP3
(SARSr-CoV)		4 / 7
LEU C 413
LEU C 421
GLU C 402
ARG C 430
1.23A22.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.41A18.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		5 / 10
ILE S 345
LYS S 323
ALA S 384
LEU S 499
VAL S 497
1.54A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3bgf F26G19 FAB
(Mus
musculus)		4 / 6
LEU L  78
LYS L 107
GLN L   6
PHE L  83
1.47A18.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
PHE B 588
LEU B 591
LEU B 595
PRO B 451
1.10A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.38A16.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.39A17.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
PHE A 223
ALA A 267
LEU A 272
ASN A 274
LEU A 271
1.56A24.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.44A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
LEU B 268
LEU D 208
ARG D 217
GLU D 270
1.45A23.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 6
LEU D 106
LYS D  86
GLN D 113
PHE D  75
1.52A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
LEU A  45
LEU A  29
ARG A  39
GLU A  70
1.45A22.22
None
None
PO4  A 124 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B 253
ALA B 210
GLN B 299
ILE B 249
LEU B 250
1.39A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.43A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B 253
ALA B 210
GLN B 299
ILE B 249
LEU B 250
1.43A16.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.43A16.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
ILE D  43
LYS D  61
LEU D  87
LEU D  89
VAL D  77
1.36A24.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.44A16.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 7
LEU A 262
PRO A  62
ARG A 279
ARG A 283
1.46A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3sci ACE2
(Homo
sapiens)		4 / 7
PHE B 588
LEU B 591
LEU B 595
PRO B 451
1.18A12.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE F 345
LYS F 324
ALA F 384
LEU F 499
VAL F 497
1.53A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		3scl SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE E 345
LYS E 324
ALA E 384
LEU E 499
VAL E 497
1.57A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
PHE B 588
LEU B 591
LEU B 595
PRO B 451
1.15A12.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.38A16.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 282
ALA A 210
THR A 257
ASP A 216
LEU A 268
1.51A16.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 114
PHE B 150
THR B 175
LEU B 177
VAL B  13
1.44A17.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
LEU A 253
ALA A 210
ASP A 295
HIS A 246
ILE A 249
LEU A 250
1.79A17.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
LEU A 253
ALA A 210
ASP A 295
HIS A 246
ILE A 249
LEU A 250
1.80A17.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.44A17.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		4mm3 UBIQUITIN
(Homo
sapiens)		5 / 10
ILE A  23
LYS A  27
LEU A  50
LEU A  67
VAL A   5
1.38A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 12
ILE A 289
THR A 257
LEU A 284
VAL A 268
PHE A 263
1.40A18.39
None
None
None
None
PO4  A 404 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 6
ASN A 267
LYS A 141
ILE A 152
PHE A 137
1.39A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 114
PHE A 150
THR A 175
LEU A 177
VAL A  13
1.40A17.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5c5n 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 282
ALA A 210
ILE A 213
THR A 304
ASP A 216
1.52A18.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
PHE B 514
LEU B 442
LEU B 508
ARG B 310
1.40A13.12
None
None
None
G3A  B 606 (-2.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 7
PHE B 514
LEU B 442
LEU B 508
ARG B 310
1.21A13.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		6 / 12
VAL B 381
ILE B 510
LEU B 442
VAL B 317
LEU B 321
PHE B 445
1.75A13.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		5e6j POLYUBIQUITIN-B
(synthetic
construct)		5 / 10
ILE F  23
LYS F  27
LEU F  50
LEU F  67
VAL F   5
1.37A12.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5f22 NSP8
(SARSr-CoV)		4 / 7
PHE B  97
LEU B 100
LEU B 108
PRO B 121
1.22A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		5f22 NSP8
NSP7
(SARSr-CoV)		5 / 10
ARG B 116
ILE B 112
ALA B 115
LEU A  61
LEU A  65
1.47A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 6
ASN D 160
LYS D 200
GLN D 168
PHE D 217
1.16A13.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 10
PHE C 146
ASN C 104
LEU C 117
LEU C 109
VAL C  91
1.59A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		6 / 12
VAL A 381
ILE A 510
LEU A 442
VAL A 317
LEU A 321
PHE A 445
1.75A13.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU C1031
ASN C 896
GLN C 902
ILE C 905
0.97A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
TYR A  87
ALA A 146
ILE A 296
ASP A 174
ILE A 300
1.28A17.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ARG A 126
ILE A 125
ALA A 127
LEU A 222
LEU A 224
1.51A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ASN A 122
GLN A 147
ILE A 152
PHE A 130
1.51A17.69
NAG  A 602 (-4.3A)
NAG  A 602 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
ASN B 907
GLN B 915
ILE B 704
PHE B1034
1.54A10.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
TYR B  87
ALA B 146
ILE B 296
ASP B 174
ILE B 300
1.27A6.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
ARG A 126
ILE A 125
ALA A 127
LEU A 222
LEU A 224
1.58A14.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5x5c S PROTEIN
(MERS-CoV)		4 / 7
PHE B 571
LEU B 443
PRO B 430
ARG C1057
1.32A6.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5x5f S PROTEIN
(MERS-CoV)		4 / 6
LEU A 893
ASN A 870
GLN A1003
PHE A1012
1.53A6.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
ILE A 428
THR A 424
VAL A 575
LEU A 441
THR A 574
1.43A6.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		4 / 6
LEU C 948
ASN A 937
GLN C 936
ILE b  11
1.43A24.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ARG B 126
ILE B 125
ALA B 127
LEU B 222
LEU B 224
1.24A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ASN A 122
GLN A 147
ILE A 152
PHE A 130
1.13A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
LEU A 222
LEU A 224
ARG B 449
GLU A  45
1.41A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU A 681
ILE A 656
THR A 631
GLN A 630
ILE C 852
1.20A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
ARG C 126
ILE C 125
ALA C 127
LEU C 222
LEU C 224
1.51A13.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
ASN C 907
GLN C 915
ILE C 704
PHE C1034
1.54A8.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
ARG B 747
ASN B 746
ALA B 748
LEU B 994
VAL B 990
1.26A14.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
LEU B 515
LEU B 374
PRO B 565
ARG B 315
1.35A8.31
None
None
None
NAG  B1306 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
ASN A 122
GLN A 147
ILE A 152
PHE A 130
1.20A8.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU B 377
LEU B 374
ALA B 371
ASP B 351
ILE B 345
1.48A8.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6lzg ACE2
(Homo
sapiens)		5 / 12
ALA A 304
ILE A 307
THR A 365
ASP A 335
HIS A 345
1.32A13.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m0j ACE2
(Homo
sapiens)		5 / 12
ALA A 304
ILE A 307
THR A 365
ASP A 335
HIS A 345
1.31A12.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6m17 ACE2
(Homo
sapiens)		4 / 7
PHE B 588
LEU B 591
LEU B 595
PRO B 451
1.24A10.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		6m1d ACE2
(Homo
sapiens)		5 / 12
MET D 706
ARG D 705
ILE D 727
ILE D 711
TYR D 649
1.72A13.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 10
ILE A 545
ALA A 271
LEU A 541
LEU A  77
VAL A 275
1.60A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE B 800
ALA B1038
LEU B 920
LEU B 927
VAL B 708
1.39A13.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6nur NSP12
(SARSr-CoV)		5 / 10
ILE A 632
ASN A 790
LEU A 308
ASN A 312
LEU A 469
1.47A16.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6nur NSP8
(SARSr-CoV)		4 / 7
PHE D  92
LEU D  95
LEU D 103
PRO D 116
1.16A23.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6nur NSP12
(SARSr-CoV)		5 / 12
PHE A 340
ILE A 333
THR A 344
VAL A 335
LEU A 366
1.38A8.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		6nus NSP12
NSP8
(SARSr-CoV)		5 / 12
MET B  87
ALA B  86
ARG B  80
SER A 518
ILE A 562
1.36A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		6nus NSP12
(SARSr-CoV)		6 / 12
MET A 124
ALA A 125
ILE A 145
ILE A 244
TYR A 788
HIS A 133
1.62A12.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6nus NSP12
(SARSr-CoV)		4 / 7
PHE A 275
LEU A 282
PRO A 461
ARG A 349
1.23A8.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		6vw1 ACE2
(Homo
sapiens)		4 / 7
PHE B 588
LEU B 591
LEU B 595
PRO B 451
1.18A13.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
TYR L  86
ALA L  84
GLN L  42
ILE L  48
LEU L  73
1.52A22.16
None
None
SO4  L 302 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
LEU L  47
ILE L  21
THR L 102
ASP L  82
LEU L  46
1.73A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
LEU L  78
ALA L  19
ILE L  21
THR L 102
ASP L  82
1.66A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU L  84
ALA L  19
ILE L  21
THR L 108
ASP L  88
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU C  84
ALA C  19
ILE C  21
THR C 108
ASP C  88
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR L  92
ALA L  90
GLN L  48
ILE L  54
LEU L  79
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR C  92
ALA C  90
GLN C  48
ILE C  54
LEU C  79
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
TYR L  92
ALA L  90
GLN L  48
ILE L  54
LEU L  79
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU L  84
ALA L  19
ILE L  21
THR L 108
ASP L  88
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
TYR L  92
ALA L  90
GLN L  48
ILE L  54
LEU L  79
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
LEU C  84
ALA C  19
ILE C  21
THR C 108
ASP C  88
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
TYR C  92
ALA C  90
GLN C  48
ILE C  54
LEU C  79
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
LEU L  84
ALA L  19
ILE L  21
THR L 108
ASP L  88
1.68A
None