Ligand ID: ID8


Drugbank ID:
DB00784
(Mefenamic acid)


Indication:
For the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever.

Get human targets for ID8 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'ID8'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.27A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.77A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
VAL B  41
LEU A  97
MET A 101
1.31A12.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU A  88
SER B   5
TYR A  31
GLY A 104
ALA A 107
1.46A12.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		1ssk NUCLEOCAPSID PROTEIN
(SARSr)		3 / 3
PRO A  95
TYR A  90
GLY A  57
0.94A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 123
LEU A  30
MET A  17
1.63A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		1x7q HLA, A-11
(Homo
sapiens)		4 / 8
LEU A 215
LEU A 206
LYS A 186
LEU A 272
1.46A17.49
9.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 123
LEU A  30
MET A  17
1.52A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B1125
LEU B1115
VAL B1013
GLY B1011
SER A  10
1.19A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B1125
LEU B1115
VAL B1013
GLY B1011
SER A  10
1.17A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		1zv7 SPIKE GLYCOPROTEIN
(SARS-COV
FRA)		4 / 8
GLN B  13
LYS A  24
ASN A  27
LEU A  30
1.32A9.90
26.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
VAL B 125
LEU B 115
VAL B  13
GLY B  11
SER A  10
1.24A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER A  10
1.74A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 8
LEU A 265
LEU A 253
LYS A 252
LEU A 225
1.09A19.77
11.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		6 / 12
VAL B 347
LEU B 322
LEU B 351
VAL B 198
ALA B 199
LEU B 192
1.55A17.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		3 / 3
VAL E 135
LEU A  18
MET A  57
0.88A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		3 / 3
SER C  15
LEU B  45
MET G  92
0.87A9.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		4 / 8
LEU C  65
LEU C  76
LEU G 100
ARG G 116
1.24A12.68
21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		4 / 8
GLN G  24
LEU G  40
LYS G  41
LEU G  47
1.37A21.70
14.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2ajf ACE2
(Homo
sapiens)		3 / 3
VAL A 132
LEU A 179
MET A 123
0.77A21.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2ajf ACE2
(Homo
sapiens)		4 / 8
GLN A  96
LEU A 392
LEU A  91
ASN A  90
1.18A20.80
5.83
None
None
None
NAG  A1090 (-1.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2ajf ACE2
(Homo
sapiens)		6 / 12
VAL B 244
TYR B 237
LEU B 240
TYR B 252
GLY B 268
LEU B 444
1.80A21.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.34A19.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.23A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.75A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		3 / 3
SER A 328
LEU B 354
MET A 323
1.21A13.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.32A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 8
LEU A  76
LEU A  94
ASN A  38
LEU A  84
1.44A20.50
14.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
SER C 115
LEU C 174
MET C 170
1.67A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		3 / 3
PRO A 104
TYR A 107
GLY A  41
1.22A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		3 / 3
SER D  71
LEU D  18
MET D  83
1.54A17.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2gri NSP3
(SARSr)		4 / 8
LEU A  36
LYS A  34
ASN A  37
ARG A 102
1.41A15.34
13.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.34A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2hsx LEADER PROTEIN
P65 HOMOLOG
NSP1
(SARSr-CoV)		4 / 8
LEU A  96
LYS A  36
LEU A   7
ARG A  32
1.44A16.57
25.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2idy NSP3
(SARSr-CoV)		3 / 3
VAL A  35
LEU A  90
MET A 103
1.35A12.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 8
LEU B 340
LEU B 353
LYS B 356
ASN B 355
1.35A16.52
17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2kys NSP7
(SARSr-CoV)		4 / 8
LEU A  62
LEU A  73
ASN A  71
ARG A  72
1.36A12.39
21.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		4 / 8
LEU A  65
LEU A 160
LEU A 168
ARG A 108
1.22A16.92
15.45
None
None
None
EDO  A 638 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		2og3 NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		3 / 3
PRO A  74
TYR A  88
GLY A  86
0.94A18.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
VAL B 125
LEU B 115
VAL B  13
GLY B  11
SER A  10
1.22A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER A  10
1.73A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.20A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.72A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2qc2 3C-LIKE PROTEINASE
(-)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.72A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.24A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2rnk REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
SER A 634
LEU A 627
MET A 624
1.45A15.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2v6n REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
SER A 158
LEU A  86
MET A 162
1.21A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		3 / 3
SER B 147
LEU B 167
MET B 165
1.75A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.34A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.22A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.73A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2w2g NSP3
(SARSr-CoV)		5 / 12
TYR A 495
VAL A 445
GLY A 446
ALA A 474
LEU A 475
1.26A18.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2w2g NSP3
(SARSr-CoV)		5 / 12
TYR A 495
VAL A 445
GLY A 446
ALA A 474
LEU A 475
1.24A18.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2z9k 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU B  57
LEU B  50
ASN B  51
ARG B 188
1.31A23.54
8.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.20A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3bgf F26G19 FAB
(Mus
musculus)		3 / 3
SER H  17
LEU H  69
MET H  80
1.54A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		3bgf F26G19 FAB
(Mus
musculus)		3 / 3
PRO L 120
TYR L 186
GLY L 129
0.92A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
TYR C  32
LEU B 100
TYR C  91
SER C  52
TYR C  71
1.77A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
GLN B  96
LEU B 392
LEU B  91
ASN B  90
1.31A20.42
5.83
None
None
None
NDG  B 616 (-2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
VAL B 343
LEU B 176
MET B 123
0.72A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B 123
LEU B  30
MET B  17
1.57A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.75A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.23A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL B  18
LEU B  58
MET B  82
1.35A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 147
LEU A 167
MET A 165
1.75A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B 123
LEU B  30
MET B  17
1.63A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.24A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER A  10
1.75A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.23A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER A  10
1.75A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.31A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3i6g HLA, A-2
MEMBRANE PROTEIN
(Homo
sapiens)		3 / 3
SER D  71
LEU F   4
MET F   2
1.42A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		3i6g HLA, A-2
(Homo
sapiens)		4 / 8
LEU D 215
LEU D 206
LYS D 186
LEU D 272
1.39A17.90
12.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		3i6k HLA, A-2
MEMBRANE
GLYCOPROTEIN PEPTIDE
(Homo
sapiens;
SARS-COV
TJF)		5 / 12
TYR A   7
LEU C   1
TYR A  99
HIS A  70
SER A  71
1.69A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL C  18
LEU C  58
MET C  82
1.26A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.17A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.35A18.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B 147
LEU B 167
MET B 165
1.73A18.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.73A18.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.22A18.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 147
LEU A 167
MET A 165
1.69A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.24A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.77A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B 147
LEU B 167
MET B 165
1.74A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3scj SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
SER F 370
LEU F 412
MET F 417
1.61A14.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3scj ACE2
(Homo
sapiens)		3 / 3
VAL B 343
LEU B 176
MET B 123
0.76A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
VAL B 132
LEU B 179
MET B 123
0.68A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
GLN A  96
LEU A 392
LEU A  91
ASN A  90
1.27A20.42
5.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3vb6 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER A  10
1.70A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.22A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.73A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL B  18
LEU B  58
MET B  82
1.33A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B 123
LEU B  30
MET B  17
1.49A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4m0w REPLICASE
POLYPROTEIN 1A
UBIQUITIN
(Bos
taurus;
SARSr-CoV)		5 / 12
TYR A 269
LEU B  73
GLY A 210
ALA A 247
SER A 246
1.16A19.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
SER A 115
LEU A 174
MET A 170
1.71A19.41
 NA  A 402 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr)		3 / 3
PRO A 249
TYR A 269
GLY A 267
0.68A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU A  57
LEU A  50
ASN A  51
ARG A 188
1.20A23.54
8.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 123
LEU A  30
MET A  17
1.55A19.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		3 / 3
SER A 115
LEU A 174
MET A 170
1.67A19.96
OCS  A 112 ( 4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 158
LEU A  86
MET A 162
1.11A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER A  10
1.71A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER A  10
1.75A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 125
LEU B 115
VAL B  13
GLY B  11
SER A  10
1.27A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.32A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
LEU B 177
LEU B 419
ASN B 410
LEU B 409
1.26A20.86
6.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
LEU B 177
LEU B 419
ASN B 410
LEU B 409
1.19A21.19
6.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
VAL D 269
SER D 271
VAL D  91
GLY D  93
LEU D 152
1.35A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
PRO A 249
TYR A 269
GLY A 267
0.62A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
LEU A 133
LEU A 118
LEU A 173
ARG A 141
1.44A20.91
8.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5e6j REPLICASE
POLYPROTEIN 1AB
UBIQUITIN
(SARSr-CoV;
synthetic
construct)		5 / 12
TYR A 269
LEU B  73
GLY A 210
ALA A 247
SER A 246
1.18A19.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5f22 NSP8
NSP7
(SARSr-CoV)		3 / 3
SER B  90
LEU A  81
MET A  80
1.68A12.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5f22 NSP8
NSP7
(SARSr-CoV)		3 / 3
VAL B 135
LEU A  18
MET A  57
0.93A12.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5f22 NSP8
NSP7
(SARSr-CoV)		4 / 8
LEU B  96
LEU B 103
LEU A  61
ARG B 101
1.34A18.21
20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		5ko3 ORF1A
(MERS-CoV)		3 / 3
PRO A 163
TYR A 112
GLY A 277
1.15A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 8
LEU D 177
LEU D 419
ASN D 410
LEU D 409
1.10A20.96
6.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5r7z 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.34A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
1.72A14.52
None
None
DMS  A 402 ( 4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.36A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5tl6 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR B 269
LEU A 154
GLY B 210
ALA B 247
SER B 246
1.07A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5tl6 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens;
SARSr-CoV)		5 / 12
TRP A 123
GLY B 210
ALA B 247
SER B 246
LEU B 212
1.38A10.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5tl6 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens;
SARSr-CoV)		5 / 12
TRP A 123
GLY B 210
ALA B 247
SER B 246
LEU B 212
1.36A10.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
PRO B 249
TYR B 269
GLY B 267
0.60A22.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5tl7 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus;
SARSr-CoV)		3 / 3
SER B 156
LEU A 122
MET A 129
1.66A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
SER B 289
LEU B 264
MET B 263
1.59A18.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		3 / 3
PRO A1051
TYR A1049
GLY A1028
0.88A14.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5x59 S PROTEIN
(MERS-CoV)		4 / 8
LEU A 821
LEU A1070
ASN A1072
LEU A1075
1.45A14.96
3.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
LEU A 978
ASN A 960
LEU A 963
ARG A 982
1.44A13.69
3.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		3 / 3
VAL C1050
LEU A 859
MET A1011
1.14A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		5x5c S PROTEIN
(MERS-CoV)		3 / 3
PRO C1143
TYR C1141
GLY C1120
0.81A12.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5x5f S PROTEIN
(MERS-CoV)		3 / 3
VAL C 724
LEU A 938
MET A 939
1.21A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5x5f S PROTEIN
(MERS-CoV)		3 / 3
SER C 761
LEU A 938
MET A 939
1.74A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
PRO B1051
TYR B1049
GLY B1028
0.93A16.31
PRO  B1051 ( 1.1A)
TYR  B1049 ( 1.3A)
GLY  B1028 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL C 606
LEU C 615
VAL C 581
GLY C 579
SER C 577
1.48A18.31
VAL  C 606 ( 0.6A)
LEU  C 615 ( 0.6A)
VAL  C 581 ( 0.6A)
GLY  C 579 ( 0.0A)
SER  C 577 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
SER A 115
LEU A 174
MET A 170
1.64A19.41
 NA  A 405 (-2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		4 / 8
LEU A 927
LEU C 930
LYS C 929
LEU c  18
1.37A14.02
26.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		3 / 3
SER B 919
LEU b  18
MET b  22
1.25A9.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
GLN A 835
LEU B 538
LYS B 521
ASN B 522
1.33A16.00
4.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
PRO C1051
TYR C1049
GLY C1028
0.81A14.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
VAL A 628
LEU A 681
MET A 679
1.07A18.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
SER A 370
LEU A 412
MET A 417
1.31A18.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
PRO B1051
TYR B1049
GLY B1028
0.86A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
PRO A1051
TYR A1049
GLY A1028
0.74A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
VAL B 510
LEU B 412
MET B 417
1.08A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
SER B 380
LEU B 412
MET B 417
1.38A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6cs2 ACE2
(Homo
sapiens)		3 / 3
VAL D 132
LEU D 179
MET D 123
0.96A21.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6cs2 ACE2
(Homo
sapiens)		4 / 8
GLN D  96
LEU D 392
LEU D  91
ASN D  90
1.10A19.97
5.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6jyt HELICASE
(SARSr-CoV)		3 / 3
SER B 513
LEU B 581
MET B 576
1.18A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6lvn SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 8
GLN D  13
LYS B  24
ASN B  27
LEU B  30
1.16A10.51
23.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 8
LEU F 981
LEU D 977
LYS D1163
ARG D 983
1.44A18.69
16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6lze VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.37A20.28
DMS  A 403 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
1.72A20.28
None
None
DMS  A 402 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6m0j ACE2
(Homo
sapiens)		4 / 8
GLN A  96
LEU A 392
LEU A  91
ASN A  90
1.29A20.80
5.83
None
None
None
NAG  A 902 (-1.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m0j ACE2
SPIKE RECEPTOR
BINDING DOMAIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
VAL E 445
LEU A 359
MET A 332
1.21A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.40A20.21
DMS  A 401 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A  57
LEU A  50
ASN A  51
ARG A 188
1.56A23.48

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
SER A 147
LEU A 167
MET A 165
1.80A20.21
None
None
N0A  D   2 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
1.72A20.21
None
None
DMS  A 404 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		3 / 3
SER A 417
LEU A 427
MET A 423
1.57A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m17 ACE2
(Homo
sapiens)		3 / 3
VAL B 132
LEU B 179
MET B 123
1.02A21.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		6 / 12
LEU C 120
LEU C 494
VAL C 589
GLY C 591
ALA C 590
SER C 594
1.55A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 8
GLN A 145
LEU A 140
ASN A 142
LEU A 148
1.33A17.92
7.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6m1d ACE2
(Homo
sapiens)		4 / 8
GLN D  96
LEU D 392
LEU D  91
ASN D  90
1.05A17.16
4.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
VAL D 125
LEU D 115
SER D 113
VAL D  13
GLY D  11
SER B  10
1.75A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER C  10
1.30A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
VAL B  18
LEU B  58
MET B  82
1.40A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
VAL C 125
LEU C 115
SER C 113
VAL C  13
GLY C  11
SER A  10
1.73A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C  86
LEU C  87
VAL C  36
GLY C  29
LEU C 177
1.69A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL D  86
LEU D  87
VAL D  36
GLY D  29
LEU D 177
1.68A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C 271
TRP C 218
ALA C 285
SER C 284
LEU C 286
1.68A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU D 271
TRP D 218
ALA D 285
SER D 284
LEU D 286
1.59A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER C  10
1.78A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C 125
LEU C 115
VAL C  13
GLY C  11
SER A  10
1.24A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL D 125
LEU D 115
VAL D  13
GLY D  11
SER B  10
1.29A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
VAL D  18
LEU D  58
MET D  82
1.38A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
VAL C  18
LEU C  58
MET C  82
1.41A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B 125
LEU B 115
VAL B  13
GLY B  11
SER D  10
1.26A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER D  10
1.75A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
SER A 123
LEU A  30
MET A  17
1.55A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.37A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
SER B 123
LEU B  30
MET B  17
1.52A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
1.72A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2q 3CL PROTEASE
(SARS-CoV-2)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.37A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU C  65
LEU C 160
LEU C 168
ARG C 108
1.39A16.37
16.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
PRO B  74
TYR B  88
GLY B  86
1.04A18.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 127
LEU A 207
TYR A 149
VAL A 182
ALA A 185
1.23A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		4 / 8
GLN A 698
LEU A 630
ASN A 791
LEU A 786
1.58A17.78

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 514
TYR A 516
LEU A 498
GLY A 503
ALA A 502
1.63A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP12
(SARS-CoV-2)		3 / 3
SER A 564
LEU A 673
MET A 666
1.49A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP12
(SARS-CoV-2)		3 / 3
VAL A  31
LEU A 212
MET A 124
1.77A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6m71 NSP12
(SARS-CoV-2)		3 / 3
PRO A 537
TYR A 346
GLY A 345
0.99A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 247
LEU A 142
LYS A 143
LEU A 178
1.53A17.78

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP12
(SARS-CoV-2)		3 / 3
SER A 236
LEU A 127
MET A 124
1.77A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6m71 NSP12
(SARS-CoV-2)		3 / 3
PRO A 918
TYR A 595
GLY A 597
1.49A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP7
NSP8
(SARS-CoV-2)		3 / 3
SER C   4
LEU D 103
MET C  52
1.36A9.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 142
LEU A 247
LEU A 178
ARG A 132
1.57A17.78

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 251
SER A 318
ASN A 314
TYR A 294
PHE A 313
1.73A15.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP12
(SARS-CoV-2)		3 / 3
SER A 239
LEU A 127
MET A 124
1.46A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP12
NSP8
(SARS-CoV-2)		3 / 3
VAL A 535
LEU B  91
MET A 380
1.16A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP7
NSP8
(SARS-CoV-2)		3 / 3
VAL D 130
LEU C  13
MET C  52
0.93A18.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		4 / 8
GLN A 468
LEU A 786
LYS A 783
ARG A 132
1.66A17.78

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 630
LEU A 663
TYR A 619
VAL A 693
ALA A 690
1.65A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU B 122
LEU B 128
ALA A 399
SER A 397
LEU A 388
1.62A18.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
PRO A1051
TYR A1049
GLY A1028
0.80A13.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
LEU A 978
LEU A 983
ARG B 977
ARG A 977
1.37A13.62
4.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		3 / 3
PRO H 108
TYR L  31
GLY L  96
0.95A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6nur NSP7
NSP8
(SARSr-CoV)		3 / 3
VAL D 130
LEU C  13
MET C  52
0.85A19.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6nur NSP12
NSP8
(SARSr-CoV)		3 / 3
VAL A 535
LEU B  91
MET A 380
1.19A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6nur NSP7
NSP8
(SARSr-CoV)		3 / 3
SER C   4
LEU D 103
MET C  52
1.34A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		6nur NSP12
(SARSr-CoV)		5 / 12
LEU A 251
SER A 318
ASN A 314
TYR A 294
PHE A 313
1.74A15.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6nus NSP12
(SARSr-CoV)		4 / 8
LEU A 142
LEU A 247
LEU A 178
ARG A 132
1.36A17.43
4.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6nus NSP12
(SARSr-CoV)		3 / 3
PRO A 537
TYR A 346
GLY A 345
0.87A15.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6nus NSP12
(SARSr-CoV)		3 / 3
SER A 239
LEU A 127
MET A 124
1.38A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 296
SER C 297
VAL C 308
GLY C 601
SER C 605
1.42A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
PRO B1069
TYR B1067
GLY B1046
0.82A13.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
SER A 884
LEU A 916
MET A 902
1.66A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
LEU A 945
LYS A 825
LEU A 828
ARG A 815
1.38A12.22
3.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
LEU E 368
SER E 366
ALA E 363
LEU E 335
1.36A17.38
NAG  E 602 (-4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B  32
LEU B  43
VAL B  10
ALA B   7
LEU B   3
1.48A19.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6vxs NSP3
(SARS-CoV-2)		4 / 8
LEU A  75
LEU A  93
ASN A  37
LEU A  83
1.55A
SO4  A 201 (-4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL B  36
LEU B 123
LEU B  93
VAL B 151
LEU B 127
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		6 / 12
LEU A 127
SER A 128
VAL A  96
GLY A  79
SER A 111
LEU A 108
1.77A
None
None
None
SO4  A 201 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL A  36
LEU A 123
LEU A  93
VAL A 151
LEU A 127
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B 127
SER B 128
VAL B  96
GLY B  79
LEU B 108
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
VAL A  96
GLY A  79
SER A 111
LEU A 108
1.68A
None
None
SO4  A 201 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
VAL A  77
GLY A  97
SER A 128
LEU A 109
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6vxs NSP3
(SARS-CoV-2)		4 / 8
LEU B  75
LEU B  93
ASN B  37
LEU B  83
1.58A
SO4  B 201 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL A 155
LEU A 160
LEU A 153
GLY A 130
ALA A 129
1.55A
SO4  A 203 (-4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL B 155
LEU B 160
LEU B 153
GLY B 130
ALA B 129
1.56A
SO4  B 204 (-3.7A)
SO4  B 204 (-4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
PRO A1069
TYR A1067
GLY A1046
0.73A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
PRO A1069
TYR A1067
GLY A1046
0.71A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		3 / 3
PRO C  73
TYR C  87
GLY C  85
0.94A16.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w02 NSP3
(SARS-CoV-2)		4 / 8
LEU B  75
LEU B  93
ASN B  37
LEU B  83
1.46A20.59
11.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w37 PROTEIN 7A
(SARS-CoV-2)		5 / 12
SER A  66
TYR A   5
VAL A   9
ALA A  64
SER A  45
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
LEU H 138
LEU L 135
VAL H 184
ALA H 136
SER H 127
1.71A12.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL L 133
LEU L 135
GLY H 139
SER H 179
LEU H 141
1.77A15.62
None
None
None
GOL  L 301 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
TYR C 369
LEU C 368
TYR C 380
VAL C 382
LEU C 513
1.80A15.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
LEU C 513
LEU C 387
LYS C 386
LEU C 368
1.78A20.94
14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
LEU L  11
LYS L  24
ASN L  22
LEU L  73
1.67A21.48
14.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		3 / 3
PRO C 412
TYR C 380
GLY C 431
1.78A19.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		3 / 3
PRO H 100
TYR L  91
GLY H  97
1.69A18.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
VAL A6865
LEU A6978
MET A6982
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6w61 NSP10
(SARS-CoV-2)		3 / 3
PRO B4337
TYR B4329
GLY B4341
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6825
ASN A6996
LEU A7037
ARG A7030
1.53A19.13
17.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
GLN A7064
LEU A7060
LEU A7070
ASN A7066
1.43A19.13
17.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6924
LEU A6959
TRP A6886
VAL A6859
ALA A6858
1.75A13.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A7052
LYS A7051
LEU A6887
ARG A7053
1.63A19.13
17.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  36
LEU B 123
LEU B  93
VAL B 151
LEU B 127
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		6 / 12
LEU A 127
SER A 128
VAL A  96
GLY A  79
SER A 111
LEU A 108
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B  75
LEU B  93
ASN B  37
LEU B  83
1.47A18.42
11.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 127
SER B 128
VAL B  96
GLY B  79
LEU B 108
1.62A
None
MES  B 201 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B 155
LEU B 164
GLY B 130
ALA B 129
LEU B 126
1.62A
None
None
MES  B 201 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  24
LEU B  88
VAL B  49
GLY B  48
ALA B  52
1.79A14.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 127
VAL B  96
GLY B  79
SER B 111
LEU B 108
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B  10
LEU B 164
LYS B 163
LEU B 169
1.63A18.42
11.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  49
LEU A  53
VAL A  35
ALA A 124
LEU A 127
1.78A
AMP  A 201 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B  75
LEU B  93
ASN B  37
LEU B  43
1.76A18.42
11.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A  10
LEU A 164
LYS A 163
LEU A 169
1.34A18.42
11.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A  75
LEU A  93
ASN A  37
LEU A  83
1.48A18.42
11.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B 155
LEU B 160
LEU B 153
GLY B 130
ALA B 129
1.61A
None
None
None
MES  B 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
VAL A  96
GLY A  79
SER A 111
LEU A 108
1.71A14.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  36
LEU A 123
LEU A  93
VAL A 151
LEU A 127
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
GLN C7064
LEU C7060
LEU C7070
ASN C7066
1.56A19.53
18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
VAL A7092
LEU A7093
VAL C7086
SER C6907
LEU C6909
1.63A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6924
LEU A6959
TRP A6886
VAL A6859
ALA A6858
1.74A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
GLN A7064
LEU A7060
LEU A7070
ASN A7066
1.59A19.53
18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C7052
LYS C7051
LEU C6887
ARG C7053
1.49A19.53
18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6924
LEU C6959
TRP C6886
VAL C6859
ALA C6858
1.75A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ARG A7053
LEU A7073
ALA A6858
SER A6964
LEU A6857
1.78A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU A7078
LEU A7060
LYS A7061
LEU A6961
1.78A19.53
18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C6825
ASN C6996
LEU C7037
ARG C7030
1.54A19.53
18.60
None
FMT  C7108 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		3 / 3
VAL A6865
LEU A6978
MET A6982
1.50A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6w75 NSP10
(SARS-CoV-2)		3 / 3
PRO D4337
TYR D4329
GLY D4341
1.47A17.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
VAL C7092
LEU C7093
VAL A7086
SER A6907
LEU A6909
1.50A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6857
LEU C6883
VAL C6965
ALA C6966
LEU C6848
1.80A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6w75 NSP10
(SARS-CoV-2)		3 / 3
PRO B4337
TYR B4329
GLY B4341
1.45A17.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C7050
LEU C6855
LEU C6924
ARG C7053
1.63A19.53
18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU A6825
ASN A6996
LEU A7037
ARG A7030
1.51A19.53
18.60
None
FMT  A7104 ( 3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		3 / 3
VAL C6865
LEU C6978
MET C6982
1.50A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU A7052
LYS A7051
LEU A6887
ARG A7053
1.75A19.53
18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 132
LEU A 117
LEU A 172
ARG A 140
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
PRO B  46
TYR B  27
GLY B  28
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
LEU C 132
LEU C 117
LEU C 172
ARG C 140
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 8
GLN A  11
LEU A  29
LEU A  88
LEU A  -8
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 8
GLN A  11
LEU A  -8
LEU A  88
LEU A  29
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
VAL A 102
LEU A 106
VAL A  41
ALA A  43
LEU A  88
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 8
LEU A  42
LEU A  -8
LYS A  -9
ARG A  10
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		6 / 12
LEU A 127
SER A 128
VAL A  96
GLY A  79
SER A 111
LEU A 108
1.79A
None
MES  A 201 (-4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A 155
LEU A 164
GLY A 130
ALA A 129
LEU A 126
1.50A
None
None
MES  A 201 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wcf NSP3
(SARS-CoV-2)		4 / 8
LEU A  10
LEU A 164
LYS A 163
LEU A 169
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wcf NSP3
(SARS-CoV-2)		4 / 8
LEU A  75
LEU A  93
ASN A  37
LEU A  83
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A 155
LEU A 160
LEU A 153
GLY A 130
ALA A 129
1.58A
None
None
None
MES  A 201 (-3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wen NSP3
(SARS-CoV-2)		4 / 8
LEU A  75
LEU A  93
ASN A  37
LEU A  83
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A 155
LEU A 160
LEU A 153
GLY A 130
ALA A 129
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		6 / 12
LEU A 331
SER A 332
VAL A 300
GLY A 283
SER A 315
LEU A 312
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 359
LEU A 368
GLY A 334
ALA A 333
LEU A 330
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 331
SER A 332
VAL A 300
GLY A 283
SER A 315
1.50A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 331
VAL A 300
GLY A 283
SER A 315
LEU A 312
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wey NSP3
(SARS-CoV-2)		4 / 8
LEU A 279
LEU A 297
ASN A 241
LEU A 287
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 359
LEU A 364
LEU A 357
GLY A 334
ALA A 333
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 245
LEU A 279
TYR A 272
VAL A 299
ALA A 243
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wiq NSP7
NSP8
(SARS-CoV-2)		3 / 3
SER B  85
LEU A  76
MET A  75
1.68A11.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wiq NSP7
(SARS-CoV-2)		5 / 12
LEU A  60
LEU A  13
GLY A  64
ALA A  65
LEU A  20
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU A  56
LEU B  98
ASN B 104
ARG B  96
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU B  91
LEU B 103
LEU A  60
ARG B  96
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wiq NSP7
NSP8
(SARS-CoV-2)		3 / 3
SER A   4
LEU B 103
MET A  52
1.58A9.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU B  91
LEU B 103
LEU A  59
ARG B  96
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU A  60
LEU A  71
LEU B  95
ARG B 111
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wiq NSP7
(SARS-CoV-2)		5 / 12
LEU A  60
LEU A  17
VAL A  66
GLY A  64
ALA A  65
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU B  91
LEU B  98
LEU A  56
ARG B  96
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU B 339
LEU B 352
LYS B 355
ASN B 354
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
GLN A7064
LEU A7060
LEU A7070
ASN A7066
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6959
LEU A7010
LYS A7012
LEU A6981
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
VAL A7092
LEU A7093
VAL C7086
SER C6907
LEU C6909
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
VAL C6865
LEU C6978
MET C6982
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6wjt NSP10
(SARS-CoV-2)		3 / 3
PRO D4337
TYR D4329
GLY D4341
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
GLN C7064
LEU C7060
LEU C7070
ASN C7066
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
VAL C7086
LEU C7078
MET C7058
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6wjt NSP10
(SARS-CoV-2)		3 / 3
PRO B4337
TYR B4329
GLY B4341
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU C6825
ASN C6996
LEU C7037
ARG C7030
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
VAL A6865
LEU A6978
MET A6982
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6825
ASN A6996
LEU A7037
ARG A7030
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
VAL C7092
LEU C7093
VAL A7086
SER A6907
LEU A6909
1.48A
FMT  C7107 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU C7052
LYS C7051
LEU C6887
ARG C7053
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU C7050
LEU C6855
LEU C6924
ARG C7053
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU D  64
LEU D 159
LEU D 167
ARG D 107
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
PRO D  73
TYR D 112
GLY D  85
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
PRO B  73
TYR B  87
GLY B  85
0.97A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
PRO C  73
TYR C  87
GLY C  85
0.93A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
PRO B  73
TYR B 112
GLY B  85
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU A  64
LEU A 159
LEU A 167
ARG A 107
1.40A
None
None
None
MES  B 201 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
PRO D  73
TYR D  87
GLY D  85
0.93A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
PRO A  73
TYR A  87
GLY A  85
1.02A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU B  64
LEU B 159
LEU B 167
ARG B 107
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
PRO C  73
TYR C 112
GLY C  85
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
PRO A  73
TYR A 112
GLY A  85
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		4 / 8
GLN C7064
LEU C7060
LEU C7070
ASN C7066
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		4 / 8
LEU C7052
LYS C7051
LEU C6887
ARG C7053
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wkq NSP16
(SARS-CoV-2)		3 / 3
VAL C6865
LEU C6978
MET C6982
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		4 / 8
LEU C7050
LEU C6855
LEU C6924
ARG C7053
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		4 / 8
LEU C6825
ASN C6996
LEU C7037
ARG C7030
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		4 / 8
LEU A6825
ASN A6996
LEU A7037
ARG A7030
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wkq NSP16
(SARS-CoV-2)		3 / 3
VAL A6865
LEU A6978
MET A6982
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		4 / 8
GLN A7064
LEU A7060
LEU A7070
ASN A7066
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
VAL C7092
LEU C7093
VAL A7086
SER A6907
LEU A6909
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6wkq NSP10
(SARS-CoV-2)		3 / 3
PRO D4337
TYR D4329
GLY D4341
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
VAL A7092
LEU A7093
VAL C7086
SER C6907
LEU C6909
1.61A
 NA  A7102 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6wkq NSP10
(SARS-CoV-2)		3 / 3
PRO B4337
TYR B4329
GLY B4341
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  86
LEU A  87
VAL A  36
GLY A  29
LEU A 177
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
SER A 123
LEU A  30
MET A  17
1.51A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 127
VAL C  96
GLY C  79
SER C 111
LEU C 108
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A  75
LEU A  93
ASN A  37
LEU A  83
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU C  75
LEU C  93
ASN C  37
LEU C  83
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU B  75
LEU B  93
ASN B  37
LEU B  83
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 127
SER C 128
VAL C  96
GLY C  79
LEU C 108
1.65A
None
APR  C 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D 155
LEU D 160
LEU D 153
GLY D 130
ALA D 129
1.56A
None
None
None
APR  D 201 (-3.2A)
APR  D 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C  36
LEU C 123
LEU C  93
VAL C 151
LEU C 127
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 127
SER A 128
VAL A  96
GLY A  79
LEU A 108
1.65A
None
APR  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B 155
LEU B 160
LEU B 153
GLY B 130
ALA B 129
1.55A
None
None
None
APR  B 201 (-3.3A)
APR  B 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B  36
LEU B 123
LEU B  93
VAL B 151
LEU B 127
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 155
LEU A 160
LEU A 153
GLY A 130
ALA A 129
1.57A
None
None
None
APR  A 201 (-3.5A)
APR  A 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 127
SER B 128
VAL B  96
GLY B  79
LEU B 108
1.64A
None
APR  B 201 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU D  75
LEU D  93
ASN D  37
LEU D  83
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 127
VAL B  96
GLY B  79
SER B 111
LEU B 108
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D 127
VAL D  96
GLY D  79
SER D 111
LEU D 108
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C 155
LEU C 160
LEU C 153
GLY C 130
ALA C 129
1.58A
None
None
None
APR  C 201 (-3.0A)
APR  C 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6wq3 NSP10
(SARS-CoV-2)		3 / 3
PRO B4337
TYR B4329
GLY B4341
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6825
ASN A6996
LEU A7037
ARG A7030
1.55A
GTA  A7102 (-3.8A)
GTA  A7102 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
VAL A6807
LEU A6834
MET A6840
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
GLN A7064
LEU A7060
LEU A7070
ASN A7066
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
VAL A6865
LEU A6978
MET A6982
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6959
LEU A7010
LYS A7012
LEU A6981
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		3 / 3
VAL A   6
LEU C  40
MET B  87
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
VAL A  66
VAL B 115
GLY B 113
ALA B 110
LEU A  71
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
VAL A  66
VAL B 115
GLY B 113
ALA B 110
LEU A  71
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		3 / 3
VAL D 130
LEU C  13
MET C  52
0.85A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER A  61
VAL B 115
GLY B 113
ALA B 110
LEU A  71
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		3 / 3
SER A  10
LEU C  40
MET B  87
1.18A9.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
(SARS-CoV-2)		4 / 8
LEU C  14
LEU C  35
ASN C  37
LEU C  40
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU C  56
LEU D  98
ASN D 104
ARG D  96
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
(SARS-CoV-2)		4 / 8
LEU A  14
LEU A  28
LYS A  27
LEU A  35
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU A  56
LEU B  98
ASN B 104
ARG B  96
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
(SARS-CoV-2)		4 / 8
LEU A  14
LEU A  35
ASN A  37
LEU A  40
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER C  61
VAL D 115
GLY D 113
ALA D 110
LEU C  71
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU D  91
LEU D 103
LEU C  59
ARG D  96
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		3 / 3
SER C  10
LEU A  40
MET D  87
1.25A9.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU B  91
LEU B 103
LEU A  59
ARG B  96
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		3 / 3
SER A   4
LEU B 103
MET A  52
1.42A9.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		3 / 3
VAL C   6
LEU A  40
MET D  87
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		3 / 3
VAL B 130
LEU A  13
MET A  52
0.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
SER A 147
LEU A 167
MET A 165
1.79A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
LEU A 125
LYS A 126
LEU A 132
ARG A 140
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6y2f REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
SER A 123
LEU A  30
MET A  17
1.49A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B 125
LEU B 115
VAL B  13
GLY B  11
SER A  10
1.20A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER A  10
1.71A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
1.73A14.34
None
None
DMS  A 403 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.36A14.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		3 / 3
VAL D 130
LEU C  13
MET C  52
0.88A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		3 / 3
SER A  10
LEU C  40
MET B  87
1.24A9.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		3 / 3
VAL C   6
LEU A  40
MET D  87
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL A  66
VAL B 115
GLY B 113
ALA B 110
LEU A  71
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		3 / 3
VAL A   6
LEU C  40
MET B  87
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		3 / 3
SER C  10
LEU A  40
MET D  87
1.23A9.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		3 / 3
VAL B 130
LEU A  13
MET A  52
0.82A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU A  60
LEU A  17
VAL A  66
GLY A  64
ALA A  65
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
SER C  61
VAL D 115
GLY D 113
ALA D 110
LEU C  71
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL A  66
VAL B 115
GLY B 113
ALA B 110
LEU A  71
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
SER A  61
VAL B 115
GLY B 113
ALA B 110
LEU A  71
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		3 / 3
PRO A  33
TYR A  47
GLY A  45
0.88A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
LEU A 119
LEU A  24
LYS A  25
LEU A 127
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL L 139
LEU L 141
GLY H 143
SER H 183
LEU H 145
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
PRO B 105
TYR C  97
GLY A 381
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
LEU A 368
SER A 366
ALA A 363
LEU A 335
1.33A
NAG  A 904 (-4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
LEU E 368
SER E 366
ALA E 363
LEU E 335
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
LEU E 368
TYR E 365
GLY E 339
LEU E 335
1.58A
None
None
None
NAG  E 907 ( 4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 390
TYR A 365
TYR C  55
TRP C  56
VAL A 382
1.57A
DMS  A 905 (-4.9A)
None
DMS  A 905 (-4.3A)
DMS  A 905 (-4.1A)
DMS  A 905 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
LEU A 368
TYR A 365
GLY A 339
LEU A 335
1.65A
NAG  A 904 (-4.5A)
None
None
NAG  A 904 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
LEU L  52
LEU L  79
LEU L  39
ARG L  60
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 390
TYR E 365
TYR L  55
TRP L  56
VAL E 382
1.56A
None
None
DMS  L1601 (-4.2A)
DMS  L1601 (-3.8A)
DMS  L1601 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 390
TYR E 365
TYR L  55
TRP L  56
VAL E 382
1.55A
None
None
DMS  L1601 (-4.2A)
DMS  L1601 (-3.8A)
DMS  L1601 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
LEU E 368
TYR E 365
GLY E 339
LEU E 335
1.68A
None
None
None
NAG  E 907 ( 4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
PRO H 105
TYR L  97
GLY E 381
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
LEU C  52
LEU C  79
LEU C  39
ARG C  60
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL C 139
LEU C 141
GLY B 143
SER B 183
LEU B 145
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
VAL A 382
LEU B   4
MET B   2
1.15A
DMS  A 905 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
PRO L 101
TYR L 102
GLY H  49
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL C 139
LEU C 141
GLY B 143
SER B 183
LEU B 145
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 390
TYR A 365
TYR C  55
TRP C  56
VAL A 382
1.55A
DMS  A 905 (-4.9A)
None
DMS  A 905 (-4.3A)
DMS  A 905 (-4.1A)
DMS  A 905 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL C  29
TYR C  97
GLY C  72
ALA C  57
SER C  73
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
PRO C 101
TYR C 102
GLY B  49
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL L 139
LEU L 141
GLY H 143
SER H 183
LEU H 145
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
LEU A 368
TYR A 365
GLY A 339
LEU A 335
1.54A
NAG  A 904 (-4.5A)
None
None
NAG  A 904 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
LEU E 368
TYR E 365
GLY E 339
LEU E 335
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 390
TYR E 365
TYR L  55
TRP L  56
VAL E 382
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
LEU L  52
LEU L  79
LEU L  39
ARG L  60
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
LEU E 368
TYR E 365
GLY E 339
LEU E 335
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL L 139
LEU L 141
GLY H 143
SER H 183
LEU H 145
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 390
TYR E 365
TYR L  55
TRP L  56
VAL E 382
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
PRO L 101
TYR L 102
GLY H  49
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
LEU E 368
SER E 366
ALA E 363
LEU E 335
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
LEU A 368
SER A 366
ALA A 363
LEU A 335
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 390
TYR E 365
TYR L  55
TRP L  56
VAL E 382
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL L 139
LEU L 141
GLY H 143
SER H 183
LEU H 145
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6yor IGG H CHAIN
IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
PRO H 105
TYR L  97
GLY E 381
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
LEU C  52
LEU C  79
LEU C  39
ARG C  60
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL C 139
LEU C 141
GLY B 143
SER B 183
LEU B 145
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 367
LEU A 368
TYR A 365
GLY A 339
LEU A 335
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
PRO C 101
TYR C 102
GLY B  49
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
PRO L 101
TYR L 102
GLY H  49
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL L 139
LEU L 141
GLY H 143
SER H 183
LEU H 145
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 390
TYR A 365
TYR C  55
TRP C  56
VAL A 382
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
LEU L  52
LEU L  79
LEU L  39
ARG L  60
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU A 390
TYR A 365
TYR C  55
TRP C  56
VAL A 382
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU E 390
TYR E 365
TYR L  55
TRP L  56
VAL E 382
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
LEU E 368
SER E 366
ALA E 363
LEU E 335
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL C 139
LEU C 141
GLY B 143
SER B 183
LEU B 145
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
LEU E 368
TYR E 365
GLY E 339
LEU E 335
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6yor IGG H CHAIN
IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
PRO B 105
TYR C  97
GLY A 381
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
LEU E 368
TYR E 365
GLY E 339
LEU E 335
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
SER A 147
LEU A 167
MET A 165
1.72A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU D  75
LEU D  93
ASN D  37
LEU D  83
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 155
LEU E 160
LEU E 153
GLY E 130
ALA E 129
1.45A
EDO  E 205 ( 4.2A)
None
None
EPE  E 202 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  36
LEU D 123
LEU D  93
VAL D 151
LEU D 127
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 127
VAL B  96
GLY B  79
SER B 111
LEU B 108
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU E  75
LEU E  93
ASN E  37
LEU E  83
1.46A
EPE  E 203 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 155
LEU B 160
LEU B 153
GLY B 130
ALA B 129
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  49
LEU C  53
VAL C  35
ALA C 124
LEU C 127
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  36
LEU C 123
LEU C  93
VAL C 151
LEU C 127
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 155
LEU C 160
LEU C 153
GLY C 130
ALA C 129
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU C  75
LEU C  93
ASN C  37
LEU C  83
1.47A
EPE  C 202 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU A  75
LEU A  93
ASN A  37
LEU A  83
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU B  75
LEU B  93
ASN B  37
LEU B  83
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 155
LEU A 160
LEU A 153
GLY A 130
ALA A 129
1.47A
None
None
None
EDO  A 202 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 127
VAL E  96
GLY E  79
SER E 111
LEU E 108
1.67A
None
None
EPE  E 203 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 127
SER B 128
VAL B  96
GLY B  79
SER B 111
1.61A
None
APR  B 201 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU E  10
LEU E 164
LYS E 163
LEU E 169
1.42A
EDO  E 203 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU C  75
LEU C  93
ASN C  37
LEU C  83
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  36
LEU C 123
LEU C  93
VAL C 151
LEU C 127
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 155
LEU E 160
LEU E 153
GLY E 130
ALA E 129
1.60A
APR  E 201 ( 4.9A)
None
None
APR  E 201 (-3.2A)
APR  E 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 155
LEU B 160
LEU B 153
GLY B 130
ALA B 129
1.61A
None
None
None
APR  B 201 (-3.2A)
APR  B 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU E  75
LEU E  93
ASN E  37
LEU E  83
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 127
VAL E  96
GLY E  79
SER E 111
LEU E 108
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 155
LEU B 164
GLY B 130
ALA B 129
LEU B 126
1.68A
None
None
APR  B 201 (-3.2A)
APR  B 201 (-3.6A)
APR  B 201 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 155
LEU C 160
LEU C 153
GLY C 130
ALA C 129
1.62A
APR  C 201 ( 4.9A)
None
None
APR  C 201 (-3.2A)
APR  C 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  36
LEU E 123
LEU E  93
VAL E 151
LEU E 127
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU A  75
LEU A  93
ASN A  37
LEU A  83
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  36
LEU D 123
LEU D  93
VAL D 151
LEU D 127
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D 155
LEU D 160
LEU D 153
GLY D 130
ALA D 129
1.62A
None
None
None
APR  D 201 (-3.2A)
APR  D 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU D  75
LEU D  93
ASN D  37
LEU D  83
1.49A
EDO  D 202 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU B  75
LEU B  93
ASN B  37
LEU B  83
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 155
LEU A 160
LEU A 153
GLY A 130
ALA A 129
1.61A
APR  A 201 ( 4.8A)
None
None
APR  A 201 ( 3.2A)
APR  A 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 127
VAL C  96
GLY C  79
SER C 111
LEU C 108
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 155
LEU A 164
GLY A 130
ALA A 129
LEU A 126
1.63A
None
None
MES  A 201 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 127
VAL B  96
GLY B  79
SER B 111
LEU B 108
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU B  10
LEU B 164
LYS B 163
LEU B 169
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  36
LEU A 123
LEU A  93
VAL A 151
LEU A 127
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  36
LEU C 123
LEU C  93
VAL C 151
LEU C 127
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 155
LEU C 160
LEU C 153
GLY C 130
ALA C 129
1.58A
EDO  C 206 ( 4.2A)
EDO  C 203 (-3.7A)
None
MES  C 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU C  75
LEU C  93
ASN C  37
LEU C  83
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU A  10
LEU A 164
LYS A 163
LEU A 169
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 155
LEU A 160
LEU A 153
GLY A 130
ALA A 129
1.58A
None
None
None
MES  A 201 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 127
VAL A  96
GLY A  79
SER A 111
LEU A 108
1.67A
None
None
EDO  A 204 (-3.6A)
EDO  C 205 (-3.5A)
EDO  C 205 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU B  75
LEU B  93
ASN B  37
LEU B  83
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU A  75
LEU A  93
ASN A  37
LEU A  83
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 155
LEU B 160
LEU B 153
GLY B 130
ALA B 129
1.48A
EDO  B 202 (-4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		7bqy MAIN PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 108
TYR A 182
GLY A 183
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bqy MAIN PROTEASE
(SARS-CoV-2)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 296
VAL A 212
GLY A 215
ALA A 211
LEU A 282
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
VAL C  16
LEU C  14
LEU D  91
TRP C  29
LEU C  59
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 127
LEU A 207
TYR A 149
VAL A 182
ALA A 185
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP12
(SARS-CoV-2)		3 / 3
SER A 236
LEU A 127
MET A 124
1.71A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 398
SER A 397
TYR A 674
ALA A 400
LEU A 401
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 251
SER A 318
ASN A 314
TYR A 294
PHE A 313
1.73A15.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU D 103
LEU C  60
LEU D  91
ARG D 111
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP7
NSP8
(SARS-CoV-2)		3 / 3
SER C   4
LEU D 103
MET C  52
1.36A9.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		7btf NSP12
(SARS-CoV-2)		3 / 3
PRO A 830
TYR A 925
GLY A 596
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		7btf NSP12
(SARS-CoV-2)		3 / 3
PRO A 537
TYR A 346
GLY A 345
0.96A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP12
(SARS-CoV-2)		3 / 3
SER A 239
LEU A 127
MET A 124
1.49A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP12
NSP8
(SARS-CoV-2)		3 / 3
VAL B  83
LEU B  95
MET A 380
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLN A 698
LEU A 630
ASN A 791
LEU A 786
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU D 103
LEU C  60
LEU C  13
ARG D 111
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 247
LEU A 142
LYS A 143
LEU A 178
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP12
(SARS-CoV-2)		5 / 12
ARG A 183
LEU A 282
TYR A 265
ALA A 253
LEU A 251
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		7btf NSP12
(SARS-CoV-2)		3 / 3
PRO A 830
TYR A 925
GLY A 597
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 142
LEU A 247
LEU A 178
ARG A 132
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  60
LEU D  91
GLY C  64
ALA C  65
LEU C  20
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP12
(SARS-CoV-2)		3 / 3
VAL A 704
LEU A 308
MET A 629
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 655
LEU A 308
ARG A 640
ARG A 651
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP12
(SARS-CoV-2)		3 / 3
VAL A 785
LEU A 308
MET A 629
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLN A 468
LEU A 786
LYS A 783
ARG A 132
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP8
(SARS-CoV-2)		5 / 12
VAL B 159
TYR B 138
LEU B 169
VAL B 130
ALA B 188
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 514
TYR A 516
LEU A 498
GLY A 503
ALA A 502
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP12
(SARS-CoV-2)		3 / 3
VAL A 763
LEU A 829
MET A 818
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
1.72A
None
None
DMS  A 406 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.33A
DMS  A 403 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
SER A 236
LEU A 127
MET A 124
1.67A19.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
SER A 913
LEU A 907
MET A 906
1.45A19.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 251
SER A 318
ASN A 314
TYR A 294
PHE A 313
1.67A15.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
SER A 239
LEU A 127
MET A 124
1.41A19.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv1 NSP7
(SARS-CoV-2)		4 / 8
LEU C  14
LEU C  35
ASN C  37
LEU C  40
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
LEU A 655
LEU A 308
ARG A 640
ARG A 651
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 127
LEU A 207
TYR A 149
VAL A 182
ALA A 185
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 282
SER A 318
ASN A 314
TYR A 294
PHE A 313
1.77A15.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
VAL A 763
LEU A 829
MET A 818
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
LEU A 247
LEU A 142
LYS A 143
LEU A 178
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
PRO A 537
TYR A 346
GLY A 345
0.98A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 398
SER A 397
TYR A 674
ALA A 400
LEU A 401
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
GLN A 698
LEU A 630
ASN A 791
LEU A 786
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 127
LEU A 207
TYR A 149
VAL A 182
ALA A 185
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
GLN A 468
LEU A 707
LEU A 731
ARG A 132
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 282
SER A 318
ASN A 314
TYR A 294
PHE A 313
1.77A15.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
VAL A 373
LEU A 673
MET A 666
1.01A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv2 NSP7
(SARS-CoV-2)		4 / 8
LEU C  14
LEU C  35
ASN C  37
LEU C  40
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
SER A 236
LEU A 127
MET A 124
1.55A19.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 247
LEU A 142
LYS A 143
LEU A 178
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 514
TYR A 516
LEU A 498
GLY A 503
ALA A 502
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 398
SER A 397
TYR A 674
ALA A 400
LEU A 401
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
PRO A 918
TYR A 595
GLY A 597
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
SER A 913
LEU A 907
MET A 906
1.44A19.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 182
TYR A 237
LEU A 186
VAL A 128
LEU A 245
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 240
ASN A 705
LEU A 708
ARG A 132
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
PRO A 537
TYR A 346
GLY A 345
0.97A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 655
LEU A 308
ARG A 640
ARG A 651
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 142
LEU A 247
LEU A 178
ARG A 132
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
GLN A 468
LEU A 786
LYS A 783
ARG A 132
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 146
TYR A 122
LEU A 212
TRP A 162
ALA A 130
1.66A
None