Ligand ID: ID8


Drugbank ID:
DB00784
(Mefenamic acid)


Indication:
For the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever.

Get human targets for ID8 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'ID8' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.27A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.77A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
VAL B  41
LEU A  97
MET A 101
1.31A12.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU A  88
SER B   5
TYR A  31
GLY A 104
ALA A 107
1.46A12.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		1ssk NUCLEOCAPSID PROTEIN
(SARSr)		3 / 3
PRO A  95
TYR A  90
GLY A  57
0.94A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 123
LEU A  30
MET A  17
1.63A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		1x7q HLA, A-11
(Homo
sapiens)		4 / 8
LEU A 215
LEU A 206
LYS A 186
LEU A 272
1.46A17.49
9.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 123
LEU A  30
MET A  17
1.52A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B1125
LEU B1115
VAL B1013
GLY B1011
SER A  10
1.19A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B1125
LEU B1115
VAL B1013
GLY B1011
SER A  10
1.17A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		1zv7 SPIKE GLYCOPROTEIN
(SARS-COV
FRA)		4 / 8
GLN B  13
LYS A  24
ASN A  27
LEU A  30
1.32A9.90
26.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
VAL B 125
LEU B 115
VAL B  13
GLY B  11
SER A  10
1.24A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER A  10
1.74A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 8
LEU A 265
LEU A 253
LYS A 252
LEU A 225
1.09A19.77
11.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		6 / 12
VAL B 347
LEU B 322
LEU B 351
VAL B 198
ALA B 199
LEU B 192
1.55A17.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		3 / 3
VAL E 135
LEU A  18
MET A  57
0.88A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		3 / 3
SER C  15
LEU B  45
MET G  92
0.87A9.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		4 / 8
LEU C  65
LEU C  76
LEU G 100
ARG G 116
1.24A12.68
21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		4 / 8
GLN G  24
LEU G  40
LYS G  41
LEU G  47
1.37A21.70
14.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2ajf ACE2
(Homo
sapiens)		3 / 3
VAL A 132
LEU A 179
MET A 123
0.77A21.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2ajf ACE2
(Homo
sapiens)		4 / 8
GLN A  96
LEU A 392
LEU A  91
ASN A  90
1.18A20.80
5.83
None
None
None
NAG  A1090 (-1.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2ajf ACE2
(Homo
sapiens)		6 / 12
VAL B 244
TYR B 237
LEU B 240
TYR B 252
GLY B 268
LEU B 444
1.80A21.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.34A19.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.23A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.75A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		3 / 3
SER A 328
LEU B 354
MET A 323
1.21A13.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.32A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 8
LEU A  76
LEU A  94
ASN A  38
LEU A  84
1.44A20.50
14.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
SER C 115
LEU C 174
MET C 170
1.67A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		3 / 3
PRO A 104
TYR A 107
GLY A  41
1.22A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		3 / 3
SER D  71
LEU D  18
MET D  83
1.54A17.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2gri NSP3
(SARSr)		4 / 8
LEU A  36
LYS A  34
ASN A  37
ARG A 102
1.41A15.34
13.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.34A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2hsx LEADER PROTEIN
P65 HOMOLOG
NSP1
(SARSr-CoV)		4 / 8
LEU A  96
LYS A  36
LEU A   7
ARG A  32
1.44A16.57
25.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2idy NSP3
(SARSr-CoV)		3 / 3
VAL A  35
LEU A  90
MET A 103
1.35A12.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 8
LEU B 340
LEU B 353
LYS B 356
ASN B 355
1.35A16.52
17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2kys NSP7
(SARSr-CoV)		4 / 8
LEU A  62
LEU A  73
ASN A  71
ARG A  72
1.36A12.39
21.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		4 / 8
LEU A  65
LEU A 160
LEU A 168
ARG A 108
1.22A16.92
15.45
None
None
None
EDO  A 638 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		2og3 NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		3 / 3
PRO A  74
TYR A  88
GLY A  86
0.94A18.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
VAL B 125
LEU B 115
VAL B  13
GLY B  11
SER A  10
1.22A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER A  10
1.73A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.20A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.72A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2qc2 3C-LIKE PROTEINASE
(-)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.72A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.24A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2rnk REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
SER A 634
LEU A 627
MET A 624
1.45A15.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2v6n REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
SER A 158
LEU A  86
MET A 162
1.21A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		3 / 3
SER B 147
LEU B 167
MET B 165
1.75A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.34A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.22A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.73A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2w2g NSP3
(SARSr-CoV)		5 / 12
TYR A 495
VAL A 445
GLY A 446
ALA A 474
LEU A 475
1.26A18.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2w2g NSP3
(SARSr-CoV)		5 / 12
TYR A 495
VAL A 445
GLY A 446
ALA A 474
LEU A 475
1.24A18.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2z9k 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU B  57
LEU B  50
ASN B  51
ARG B 188
1.31A23.54
8.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.20A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3bgf F26G19 FAB
(Mus
musculus)		3 / 3
SER H  17
LEU H  69
MET H  80
1.54A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		3bgf F26G19 FAB
(Mus
musculus)		3 / 3
PRO L 120
TYR L 186
GLY L 129
0.92A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
TYR C  32
LEU B 100
TYR C  91
SER C  52
TYR C  71
1.77A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
GLN B  96
LEU B 392
LEU B  91
ASN B  90
1.31A20.42
5.83
None
None
None
NDG  B 616 (-2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
VAL B 343
LEU B 176
MET B 123
0.72A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B 123
LEU B  30
MET B  17
1.57A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.75A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.23A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL B  18
LEU B  58
MET B  82
1.35A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 147
LEU A 167
MET A 165
1.75A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B 123
LEU B  30
MET B  17
1.63A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.24A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER A  10
1.75A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.23A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER A  10
1.75A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.31A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3i6g HLA, A-2
MEMBRANE PROTEIN
(Homo
sapiens)		3 / 3
SER D  71
LEU F   4
MET F   2
1.42A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		3i6g HLA, A-2
(Homo
sapiens)		4 / 8
LEU D 215
LEU D 206
LYS D 186
LEU D 272
1.39A17.90
12.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		3i6k HLA, A-2
MEMBRANE
GLYCOPROTEIN PEPTIDE
(Homo
sapiens;
SARS-COV
TJF)		5 / 12
TYR A   7
LEU C   1
TYR A  99
HIS A  70
SER A  71
1.69A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL C  18
LEU C  58
MET C  82
1.26A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.17A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.35A18.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B 147
LEU B 167
MET B 165
1.73A18.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.73A18.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.22A18.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 147
LEU A 167
MET A 165
1.69A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.24A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.77A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B 147
LEU B 167
MET B 165
1.74A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3scj SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
SER F 370
LEU F 412
MET F 417
1.61A14.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3scj ACE2
(Homo
sapiens)		3 / 3
VAL B 343
LEU B 176
MET B 123
0.76A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
VAL B 132
LEU B 179
MET B 123
0.68A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
GLN A  96
LEU A 392
LEU A  91
ASN A  90
1.27A20.42
5.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3vb6 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER A  10
1.70A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER B  10
1.22A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A 125
LEU A 115
SER A 113
VAL A  13
GLY A  11
SER B  10
1.73A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL B  18
LEU B  58
MET B  82
1.33A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B 123
LEU B  30
MET B  17
1.49A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4m0w REPLICASE
POLYPROTEIN 1A
UBIQUITIN
(Bos
taurus;
SARSr-CoV)		5 / 12
TYR A 269
LEU B  73
GLY A 210
ALA A 247
SER A 246
1.16A19.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
SER A 115
LEU A 174
MET A 170
1.71A19.41
 NA  A 402 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr)		3 / 3
PRO A 249
TYR A 269
GLY A 267
0.68A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LEU A  57
LEU A  50
ASN A  51
ARG A 188
1.20A23.54
8.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 123
LEU A  30
MET A  17
1.55A19.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4ow0 PAPAIN-LIKE PROTEASE
(SARS-COV
Urbani)		3 / 3
SER A 115
LEU A 174
MET A 170
1.67A19.96
OCS  A 112 ( 4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 158
LEU A  86
MET A 162
1.11A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER A  10
1.71A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL B 125
LEU B 115
SER B 113
VAL B  13
GLY B  11
SER A  10
1.75A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 125
LEU B 115
VAL B  13
GLY B  11
SER A  10
1.27A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
VAL A  18
LEU A  58
MET A  82
1.32A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
LEU B 177
LEU B 419
ASN B 410
LEU B 409
1.26A20.86
6.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
LEU B 177
LEU B 419
ASN B 410
LEU B 409
1.19A21.19
6.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
VAL D 269
SER D 271
VAL D  91
GLY D  93
LEU D 152
1.35A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
PRO A 249
TYR A 269
GLY A 267
0.62A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
LEU A 133
LEU A 118
LEU A 173
ARG A 141
1.44A20.91
8.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5e6j REPLICASE
POLYPROTEIN 1AB
UBIQUITIN
(SARSr-CoV;
synthetic
construct)		5 / 12
TYR A 269
LEU B  73
GLY A 210
ALA A 247
SER A 246
1.18A19.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5f22 NSP8
NSP7
(SARSr-CoV)		3 / 3
SER B  90
LEU A  81
MET A  80
1.68A12.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5f22 NSP8
NSP7
(SARSr-CoV)		3 / 3
VAL B 135
LEU A  18
MET A  57
0.93A12.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5f22 NSP8
NSP7
(SARSr-CoV)		4 / 8
LEU B  96
LEU B 103
LEU A  61
ARG B 101
1.34A18.21
20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		5ko3 ORF1A
(MERS-CoV)		3 / 3
PRO A 163
TYR A 112
GLY A 277
1.15A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 8
LEU D 177
LEU D 419
ASN D 410
LEU D 409
1.10A20.96
6.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5tl6 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR B 269
LEU A 154
GLY B 210
ALA B 247
SER B 246
1.07A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5tl6 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens;
SARSr-CoV)		5 / 12
TRP A 123
GLY B 210
ALA B 247
SER B 246
LEU B 212
1.38A10.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5tl6 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens;
SARSr-CoV)		5 / 12
TRP A 123
GLY B 210
ALA B 247
SER B 246
LEU B 212
1.36A10.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
PRO B 249
TYR B 269
GLY B 267
0.60A22.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5tl7 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus;
SARSr-CoV)		3 / 3
SER B 156
LEU A 122
MET A 129
1.66A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
SER B 289
LEU B 264
MET B 263
1.59A18.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		3 / 3
PRO A1051
TYR A1049
GLY A1028
0.88A14.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5x59 S PROTEIN
(MERS-CoV)		4 / 8
LEU A 821
LEU A1070
ASN A1072
LEU A1075
1.45A14.96
3.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
LEU A 978
ASN A 960
LEU A 963
ARG A 982
1.44A13.69
3.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		3 / 3
VAL C1050
LEU A 859
MET A1011
1.14A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		5x5c S PROTEIN
(MERS-CoV)		3 / 3
PRO C1143
TYR C1141
GLY C1120
0.81A12.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5x5f S PROTEIN
(MERS-CoV)		3 / 3
VAL C 724
LEU A 938
MET A 939
1.21A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5x5f S PROTEIN
(MERS-CoV)		3 / 3
SER C 761
LEU A 938
MET A 939
1.74A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
PRO B1051
TYR B1049
GLY B1028
0.93A16.31
PRO  B1051 ( 1.1A)
TYR  B1049 ( 1.3A)
GLY  B1028 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL C 606
LEU C 615
VAL C 581
GLY C 579
SER C 577
1.48A18.31
VAL  C 606 ( 0.6A)
LEU  C 615 ( 0.6A)
VAL  C 581 ( 0.6A)
GLY  C 579 ( 0.0A)
SER  C 577 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
SER A 115
LEU A 174
MET A 170
1.64A19.41
 NA  A 405 (-2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		4 / 8
LEU A 927
LEU C 930
LYS C 929
LEU c  18
1.37A14.02
26.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		3 / 3
SER B 919
LEU b  18
MET b  22
1.25A9.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
GLN A 835
LEU B 538
LYS B 521
ASN B 522
1.33A16.00
4.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
PRO C1051
TYR C1049
GLY C1028
0.81A14.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
VAL A 628
LEU A 681
MET A 679
1.07A18.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
SER A 370
LEU A 412
MET A 417
1.31A18.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
PRO B1051
TYR B1049
GLY B1028
0.86A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
PRO A1051
TYR A1049
GLY A1028
0.74A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
VAL B 510
LEU B 412
MET B 417
1.08A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
SER B 380
LEU B 412
MET B 417
1.38A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6cs2 ACE2
(Homo
sapiens)		3 / 3
VAL D 132
LEU D 179
MET D 123
0.96A21.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6cs2 ACE2
(Homo
sapiens)		4 / 8
GLN D  96
LEU D 392
LEU D  91
ASN D  90
1.10A19.97
5.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6jyt HELICASE
(SARSr-CoV)		3 / 3
SER B 513
LEU B 581
MET B 576
1.18A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6m0j ACE2
(Homo
sapiens)		4 / 8
GLN A  96
LEU A 392
LEU A  91
ASN A  90
1.29A20.80
5.83
None
None
None
NAG  A 902 (-1.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		3 / 3
SER A 417
LEU A 427
MET A 423
1.57A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m17 ACE2
(Homo
sapiens)		3 / 3
VAL B 132
LEU B 179
MET B 123
1.02A21.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		6 / 12
LEU C 120
LEU C 494
VAL C 589
GLY C 591
ALA C 590
SER C 594
1.55A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 8
GLN A 145
LEU A 140
ASN A 142
LEU A 148
1.33A17.92
7.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6m1d ACE2
(Homo
sapiens)		4 / 8
GLN D  96
LEU D 392
LEU D  91
ASN D  90
1.05A17.16
4.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
PRO A1051
TYR A1049
GLY A1028
0.80A13.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
LEU A 978
LEU A 983
ARG B 977
ARG A 977
1.37A13.62
4.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		3 / 3
PRO H 108
TYR L  31
GLY L  96
0.95A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6nur NSP7
NSP8
(SARSr-CoV)		3 / 3
VAL D 130
LEU C  13
MET C  52
0.85A19.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6nur NSP12
NSP8
(SARSr-CoV)		3 / 3
VAL A 535
LEU B  91
MET A 380
1.19A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6nur NSP7
NSP8
(SARSr-CoV)		3 / 3
SER C   4
LEU D 103
MET C  52
1.34A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		6nur NSP12
(SARSr-CoV)		5 / 12
LEU A 251
SER A 318
ASN A 314
TYR A 294
PHE A 313
1.74A15.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6nus NSP12
(SARSr-CoV)		4 / 8
LEU A 142
LEU A 247
LEU A 178
ARG A 132
1.36A17.43
4.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6nus NSP12
(SARSr-CoV)		3 / 3
PRO A 537
TYR A 346
GLY A 345
0.87A15.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6nus NSP12
(SARSr-CoV)		3 / 3
SER A 239
LEU A 127
MET A 124
1.38A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 367
LEU E 368
SER E 366
ALA E 363
LEU E 335
1.36A17.38
NAG  E 602 (-4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
LEU H 138
LEU L 135
VAL H 184
ALA H 136
SER H 127
1.71A12.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL L 133
LEU L 135
GLY H 139
SER H 179
LEU H 141
1.77A15.62
None
None
None
GOL  L 301 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
LEU L  11
LYS L  24
ASN L  22
LEU L  73
1.67A21.48
14.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		3 / 3
PRO H 100
TYR L  91
GLY H  97
1.69A18.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL L 139
LEU L 141
GLY H 143
SER H 183
LEU H 145
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
LEU L  52
LEU L  79
LEU L  39
ARG L  60
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
LEU C  52
LEU C  79
LEU C  39
ARG C  60
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL C 139
LEU C 141
GLY B 143
SER B 183
LEU B 145
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
PRO L 101
TYR L 102
GLY H  49
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL C 139
LEU C 141
GLY B 143
SER B 183
LEU B 145
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL C  29
TYR C  97
GLY C  72
ALA C  57
SER C  73
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
PRO C 101
TYR C 102
GLY B  49
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL L 139
LEU L 141
GLY H 143
SER H 183
LEU H 145
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
LEU L  52
LEU L  79
LEU L  39
ARG L  60
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL L 139
LEU L 141
GLY H 143
SER H 183
LEU H 145
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
PRO L 101
TYR L 102
GLY H  49
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL L 139
LEU L 141
GLY H 143
SER H 183
LEU H 145
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
LEU C  52
LEU C  79
LEU C  39
ARG C  60
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL C 139
LEU C 141
GLY B 143
SER B 183
LEU B 145
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
PRO C 101
TYR C 102
GLY B  49
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
PRO L 101
TYR L 102
GLY H  49
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL L 139
LEU L 141
GLY H 143
SER H 183
LEU H 145
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
LEU L  52
LEU L  79
LEU L  39
ARG L  60
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL C 139
LEU C 141
GLY B 143
SER B 183
LEU B 145
1.76A
None