Results

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	RMSD	Seq. Identity (%)	HETATM
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	1z1j	3C-LIKE PROTEINASE (SARSr-CoV)	6 / 11	LEU B1208 VAL B1212 ALA B1260 THR B1224 ALA B1266 LEU B1220	1.62A	21.62	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	1z1j	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 10	LEU A 208 VAL A 212 ALA A 260 ALA A 266 LEU A 220	1.42A	21.62	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	2acf	REPLICASE POLYPROTEIN 1AB (SARS-COV Tor2)	5 / 11	LEU B 342 VAL B 346 ILE B 335 ALA B 336 LEU B 308	1.25A	19.46	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	2acf	REPLICASE POLYPROTEIN 1AB (SARS-COV Tor2)	5 / 10	LEU C 342 VAL C 346 ILE C 335 ALA C 336 LEU C 308	1.27A	19.46	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	2ahm	REPLICASE POLYPROTEIN 1AB, HEAVY CHAIN REPLICASE POLYPROTEIN 1AB, LIGHT CHAIN (SARSr-CoV)	5 / 10	PHE H 97 VAL D 71 ILE H 112 ALA H 115 LEU D 61	1.34A	18.43	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	2cme	HYPOTHETICAL PROTEIN 5 (SARSr-CoV)	5 / 10	ALA G 97 LEU H 53 VAL G 95 VAL H 95 ILE G 20	1.41A	13.90	None D10 H1099 (-4.0A) None D10 H1099 ( 4.9A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	2cme	HYPOTHETICAL PROTEIN 5 (SARSr-CoV)	5 / 10	ALA F 97 LEU E 53 VAL F 95 VAL E 95 ILE F 20	1.41A	11.01	None None None D10 F1099 (-4.9A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	2d2d	3C-LIKE PROTEINASE (SARSr-CoV)	6 / 11	LEU A 208 VAL A 212 ALA A 260 THR A 224 ALA A 266 LEU A 220	1.51A	22.37	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	2d2d	3C-LIKE PROTEINASE (SARSr-CoV)	6 / 10	LEU A 208 VAL A 212 ALA A 260 THR A 224 ALA A 266 LEU A 220	1.65A	22.37	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	2fe8	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 10	ALA A 132 LEU A 133 ALA A 145 THR A 91 ALA A 150	1.28A	22.15	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	2fe8	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 11	ALA A 132 LEU A 133 ALA A 145 THR A 91 ALA A 150	1.27A	22.15	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	2fxp	SPIKE GLYCOPROTEIN (SARSr-CoV)	6 / 10	ALA A 34 LEU C 37 VAL A 33 VAL C 33 ILE C 27 LEU B 30	1.73A	11.53	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	2ozk	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	6 / 11	LEU B 142 PHE B 176 THR B 144 THR B 83 ALA B 81 LEU B 122	1.61A	20.04	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	2rhb	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	6 / 11	LEU A 142 PHE A 176 THR A 144 THR A 83 ALA A 81 LEU A 122	1.56A	19.83	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	3atw	3C-LIKE PROTEINASE (SARSr-CoV)	6 / 11	LEU A 208 VAL A 212 ALA A 260 THR A 224 ALA A 266 LEU A 220	1.66A	21.52	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	3d0h	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 10	LEU B 585 PHE B 523 ILE B 446 ALA B 443 LEU B 450	1.41A	23.43	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	3d62	3C-LIKE PROTEINASE (SARSr-CoV)	6 / 11	LEU A 208 VAL A 212 ALA A 260 THR A 224 ALA A 266 LEU A 220	1.61A	22.08	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	3d62	3C-LIKE PROTEINASE (SARSr-CoV)	6 / 10	LEU A 208 VAL A 212 ALA A 260 THR A 224 ALA A 266 LEU A 220	1.73A	22.08	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	3e9s	NSP3 (SARSr-CoV)	5 / 10	ALA A 132 LEU A 133 ALA A 145 THR A 91 ALA A 150	1.33A	22.15	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	3m3t	3C-LIKE PROTEINASE (SARSr-CoV)	6 / 11	LEU A 208 VAL A 212 ALA A 260 THR A 224 ALA A 266 LEU A 220	1.67A	21.62	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	3sck	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 10	LEU B 585 PHE B 523 ILE B 446 ALA B 443 LEU B 450	1.41A	22.91	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	3vb6	3C-LIKE PROTEINASE (SARSr-CoV)	6 / 10	LEU B 208 VAL B 212 ALA B 260 THR B 224 ALA B 266 LEU B 220	1.66A	21.62	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	3vb6	3C-LIKE PROTEINASE (SARSr-CoV)	6 / 11	LEU B 208 VAL B 212 ALA B 260 THR B 224 ALA B 266 LEU B 220	1.54A	21.62	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	4m0w	REPLICASE POLYPROTEIN 1A (SARSr-CoV)	5 / 10	ALA A 132 LEU A 133 ALA A 145 THR A 91 ALA A 150	1.36A	21.66	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	4ovz	PAPAIN-LIKE PROTEINASE (SARS-COV Urbani)	5 / 10	ALA A 132 LEU A 133 ALA A 145 THR A 91 ALA A 150	1.36A	22.15	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5c8s	GUANINE-N7 METHYLTRANSFERASE (SARSr-CoV)	6 / 11	LEU B 411 VAL B 282 PHE B 286 VAL B 421 ILE B 80 ALA B 85	1.69A	21.73	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5c8s	GUANINE-N7 METHYLTRANSFERASE (SARSr-CoV)	5 / 10	LEU B 117 VAL B 115 ILE B 87 THR B 173 LEU B 170	1.39A	21.73	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5c8t	GUANINE-N7 METHYLTRANSFERASE (SARSr-CoV)	5 / 10	LEU B 117 VAL B 115 ILE B 87 THR B 173 LEU B 170	1.34A	22.18	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5c8u	GUANINE-N7 METHYLTRANSFERASE (SARSr-CoV)	6 / 11	LEU B 411 VAL B 282 PHE B 286 VAL B 421 ILE B 80 ALA B 85	1.75A	22.18	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5e6j	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 10	ALA A 132 LEU A 133 ALA A 145 THR A 91 ALA A 150	1.37A	22.77	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5nfy	POLYPROTEIN 1AB (SARS-COV Frankfurt 1)	6 / 11	LEU B 411 VAL B 282 PHE B 286 VAL B 421 ILE B 80 ALA B 85	1.62A	22.09	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5nfy	POLYPROTEIN 1AB (SARS-COV Frankfurt 1)	5 / 10	ALA B 425 LEU B 419 VAL B 421 ALA B 85 ALA B 79	1.27A	22.09	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5rfc	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	LEU A 205 VAL A 261 VAL A 202 ALA A 234 LEU A 227	1.65A	17.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5rfc	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	LEU A 205 VAL A 247 VAL A 202 ALA A 234 LEU A 227	1.68A	17.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5rfc	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 11	LEU A 208 VAL A 212 THR A 224 ALA A 266 LEU A 220	1.65A	17.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5tl6	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 11	ALA D 132 LEU D 133 ALA D 145 THR D 91 ALA D 150	1.27A	22.10	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5tl6	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 10	ALA D 132 LEU D 133 ALA D 145 THR D 91 ALA D 150	1.28A	22.10	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5wrg	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU C 840 VAL C 718 VAL C 842 ALA C 714 ALA C 938	1.38A	17.54	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5wrg	SPIKE GLYCOPROTEIN (SARSr-CoV)	6 / 11	LEU B 840 VAL B 718 VAL B 842 THR B 841 ALA B 714 ALA B 938	1.40A	17.54	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5x29	ENVELOPE SMALL MEMBRANE PROTEIN (SARSr-CoV)	6 / 11	ALA A 32 LEU A 28 VAL A 29 PHE A 26 VAL A 25 ALA E 22	1.78A	13.37	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5x5b	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	5 / 11	ALA A 926 LEU A 930 VAL A 711 THR A 856 ALA A1037	1.16A	17.74	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5x5b	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	5 / 10	ALA A 926 LEU A 930 VAL A 708 VAL A 711 THR A 856	1.24A	17.74	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5y3q	REPLICASE POLYPROTEIN 1A (SARSr-CoV)	5 / 10	ALA A 132 LEU A 133 ALA A 145 THR A 91 ALA A 150	1.39A	20.91	NA A 406 (-4.3A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6acg	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 10	LEU C 840 VAL C 718 VAL C 842 ALA C 714 ALA C 938	1.30A	17.54	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6acg	ACE2 (Homo sapiens)	6 / 11	ALA D 443 LEU D 444 VAL D 447 VAL D 244 ALA D 242 LEU D 236	1.78A	23.76	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6acj	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 11	VAL B 718 VAL B 842 THR B 841 ALA B 714 ALA B 938	1.22A	17.54	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6acj	ACE2 (Homo sapiens)	5 / 10	LEU D 585 VAL D 581 ILE D 446 ALA D 443 LEU D 450	1.32A	23.76	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6crv	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 11	ALA A 864 THR A 869 ILE C 694 ALA C 695 ALA C 688	1.21A	17.34	None None None None NAG C1310 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6crw	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 10	ALA B 577 VAL B 601 VAL B 581 ILE B 637 ALA B 618	1.23A	17.37	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6cs2	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 11	LEU C 840 VAL C 842 THR C 841 ALA C 714 ALA C 938	1.22A	17.37	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6jyt	HELICASE (SARSr-CoV)	5 / 10	ALA A 368 LEU A 391 VAL A 305 ILE A 333 LEU A 352	1.40A	21.25	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6lze	VIRAL PROTEASE (SARS-CoV-2)	5 / 11	LEU A 208 VAL A 212 THR A 224 ALA A 266 LEU A 220	1.53A	20.87	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6lze	VIRAL PROTEASE (SARS-CoV-2)	5 / 10	VAL A 212 ALA A 260 THR A 224 ALA A 266 LEU A 220	1.54A	20.87	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6m71	NSP12 (SARS-CoV-2)	5 / 10	LEU A 786 VAL A 792 ALA A 625 THR A 680 LEU A 630	1.51A	20.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6m71	NSP12 (SARS-CoV-2)	5 / 11	ALA A 97 LEU A 119 THR A 120 ALA A 125 THR A 206	1.50A	20.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6m71	NSP12 (SARS-CoV-2)	5 / 11	ALA A 253 LEU A 251 THR A 189 ALA A 185 LEU A 187	1.53A	20.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6m71	NSP12 (SARS-CoV-2)	5 / 10	ALA A 634 LEU A 638 VAL A 693 ILE A 589 ALA A 685	1.54A	20.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6m71	NSP12 (SARS-CoV-2)	5 / 10	LEU A 241 VAL A 128 VAL A 182 ILE A 145 THR A 120	1.40A	20.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6m71	NSP12 (SARS-CoV-2)	5 / 10	ALA A 253 LEU A 251 THR A 189 ALA A 185 LEU A 187	1.48A	20.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6nus	NSP12 NSP8 (SARSr-CoV)	5 / 10	ALA B 110 VAL B 115 VAL A 341 ALA A 383 ALA B 102	1.33A	16.89	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6vsb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	6 / 11	LEU C 858 VAL C 736 VAL C 860 THR C 859 ILE C 770 ALA C 958	1.72A	16.19	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	ALA A 154 LEU A 153 VAL A 155 ALA A 129 ALA A 38	1.37A		None None SO4 A 203 (-4.0A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	ALA B 124 VAL B 36 VAL B 49 ALA B 129 LEU B 127	1.52A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6vxs	NSP3 (SARS-CoV-2)	5 / 11	ALA A 154 LEU A 153 VAL A 155 ALA A 129 ALA A 38	1.38A		None None SO4 A 203 (-4.0A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	ALA A 52 LEU A 53 VAL A 24 VAL A 35 ALA A 124	1.55A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	ALA B 124 LEU B 123 VAL B 35 VAL B 30 ALA B 21	1.56A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6vxs	NSP3 (SARS-CoV-2)	5 / 11	ALA A 124 LEU A 122 VAL A 151 THR A 149 ALA A 112	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	ALA A 124 VAL A 36 VAL A 49 ALA A 129 LEU A 127	1.54A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6vxs	NSP3 (SARS-CoV-2)	5 / 11	ALA B 154 LEU B 153 VAL B 155 ALA B 129 ALA B 38	1.35A		None None SO4 B 204 (-3.7A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	ALA B 154 LEU B 153 VAL B 155 ALA B 129 ALA B 38	1.34A		None None SO4 B 204 (-3.7A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6vxs	NSP3 (SARS-CoV-2)	5 / 11	ALA A 38 VAL A 95 VAL A 77 ALA A 134 LEU A 127	1.46A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6vxs	NSP3 (SARS-CoV-2)	6 / 11	ALA A 52 LEU A 53 VAL A 24 VAL A 35 ALA A 124 ALA A 38	1.62A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6vxs	NSP3 (SARS-CoV-2)	5 / 10	ALA A 52 VAL A 24 VAL A 35 ALA A 124 ALA A 38	1.55A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6vxs	NSP3 (SARS-CoV-2)	5 / 11	ALA B 124 LEU B 123 VAL B 35 VAL B 30 ALA B 21	1.50A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6vxs	NSP3 (SARS-CoV-2)	6 / 11	ALA B 52 LEU B 53 VAL B 24 VAL B 35 ALA B 124 ALA B 38	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w41	CR3022 FAB LIGHT CHAIN (Homo sapiens)	5 / 11	ALA L 130 LEU L 181 VAL L 150 ILE L 117 ALA L 193	1.70A	17.65	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w41	CR3022 FAB LIGHT CHAIN (Homo sapiens)	5 / 10	ALA L 34 LEU L 46 VAL L 58 ILE L 75 LEU L 73	1.77A	17.65	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w41	CR3022 FAB LIGHT CHAIN (Homo sapiens)	5 / 11	PHE L 209 VAL L 191 ILE L 117 ALA L 193 THR L 206	1.57A	17.65	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w41	CR3022 FAB LIGHT CHAIN (Homo sapiens)	5 / 11	ALA L 12 LEU L 11 VAL L 104 THR L 102 LEU L 78	1.58A	17.65	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w41	SPIKE PROTEIN S1 (SARS-CoV-2)	5 / 11	ALA C 419 LEU C 425 PHE C 400 VAL C 512 THR C 376	1.74A	16.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w41	CR3022 FAB HEAVY CHAIN (Homo sapiens)	5 / 11	ALA H 136 LEU H 189 VAL H 184 ALA H 125 LEU H 138	1.64A	15.30	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w41	CR3022 FAB LIGHT CHAIN (Homo sapiens)	5 / 10	ALA L 144 LEU L 136 VAL L 196 ALA L 111 LEU L 201	1.54A	17.65	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w41	CR3022 FAB LIGHT CHAIN (Homo sapiens)	5 / 10	PHE L 209 VAL L 191 ILE L 117 ALA L 193 THR L 206	1.61A	17.65	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w41	SPIKE PROTEIN S1 (SARS-CoV-2)	5 / 10	ALA C 419 LEU C 425 PHE C 400 VAL C 512 THR C 376	1.74A	16.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w41	CR3022 FAB LIGHT CHAIN (Homo sapiens)	5 / 10	ALA L 130 LEU L 181 VAL L 150 ILE L 117 ALA L 193	1.67A	17.65	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 11	ALA A6960 LEU A6959 ALA A6986 ALA A6858 LEU A7073	1.67A	17.21	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 10	LEU A6909 PHE A6868 VAL A6894 ILE A6925 ALA A6919	1.57A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 10	ALA A6960 LEU A6959 ALA A6986 THR A6856 LEU A7073	1.76A	17.21	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 11	LEU A6887 THR A6891 THR A7055 ALA A6858 LEU A7052	1.77A	17.21	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 11	LEU A6887 VAL A6865 THR A6891 ALA A6905 ALA A6881	1.80A	17.21	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 10	LEU A6909 VAL A6916 PHE A6868 VAL A6894 ILE A6925	1.74A	17.21	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w61	NSP10 (SARS-CoV-2)	5 / 11	VAL B4369 THR B4368 ALA B4307 THR B4309 LEU B4345	1.56A	19.68	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w61	2'-O-METHYLTRANSFERA SE NSP10 (SARS-CoV-2)	5 / 10	ALA A6877 VAL B4295 VAL A6882 ILE A6838 ALA A6843	1.78A	17.21	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 10	ALA A6858 LEU A6857 ILE A6925 ALA A6966 LEU A6959	1.78A	17.21	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 11	LEU A6909 PHE A6868 VAL A6894 ILE A6925 ALA A6919	1.67A	17.21	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	ALA A 52 VAL A 24 VAL A 35 ALA A 124 ALA A 38	1.65A	16.81	AMP A 201 ( 4.0A) None None None AMP A 201 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA B 154 LEU B 153 VAL B 155 ALA B 134 ALA B 38	1.66A	16.81	None None None None MES B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	ALA B 154 LEU B 153 VAL B 155 ALA B 129 ALA B 38	1.52A		None None None None MES B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA A 38 VAL A 95 VAL A 77 ALA A 134 LEU A 127	1.43A		AMP A 201 ( 3.9A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	ALA A 124 LEU A 123 VAL A 35 VAL A 30 ALA A 21	1.61A	16.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	ALA B 52 VAL B 24 VAL B 35 ALA B 124 ALA B 38	1.62A	16.81	None None None None MES B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	ALA A 124 LEU A 123 VAL A 35 ALA A 56 LEU A 53	1.56A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	ALA A 124 VAL A 36 VAL A 49 ALA A 129 LEU A 127	1.47A		None None AMP A 201 ( 3.7A) AMP A 201 ( 3.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA B 124 LEU B 123 VAL B 35 ALA B 56 LEU B 53	1.55A	16.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	ALA B 56 LEU B 88 VAL B 24 VAL B 35 ALA B 124	1.73A	16.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA B 124 LEU B 122 VAL B 151 THR B 149 ALA B 112	1.51A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA B 52 LEU B 53 VAL B 24 VAL B 35 ALA B 124	1.67A	16.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA B 52 VAL B 24 VAL B 35 ALA B 124 ALA B 38	1.64A	16.81	None None None None MES B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA A 124 LEU A 123 VAL A 35 ALA A 56 LEU A 53	1.54A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	ALA A 56 LEU A 88 VAL A 24 VAL A 35 ALA A 124	1.76A	16.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA A 124 VAL A 36 VAL A 49 ALA A 129 LEU A 127	1.53A		None None AMP A 201 ( 3.7A) AMP A 201 ( 3.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA A 124 LEU A 123 VAL A 35 VAL A 30 ALA A 21	1.55A	16.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	LEU A 160 VAL A 155 ALA A 38 ALA A 134 LEU A 126	1.80A	16.81	None AMP A 201 ( 4.4A) AMP A 201 ( 3.9A) None AMP A 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA B 124 LEU B 123 VAL B 35 VAL B 30 ALA B 21	1.56A	16.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA B 154 LEU B 153 VAL B 155 ALA B 129 ALA B 38	1.51A		None None None None MES B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	ALA B 124 LEU B 123 VAL B 35 ALA B 56 LEU B 53	1.58A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	ALA B 124 VAL B 36 VAL B 49 ALA B 129 LEU B 127	1.47A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA A 52 LEU A 53 VAL A 24 VAL A 35 ALA A 124	1.66A	16.81	AMP A 201 ( 4.0A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA B 124 VAL B 36 VAL B 49 ALA B 129 LEU B 127	1.55A	16.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA B 38 VAL B 95 VAL B 77 ALA B 134 LEU B 127	1.42A		MES B 201 ( 3.4A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	ALA B 124 LEU B 123 VAL B 35 VAL B 30 ALA B 21	1.63A	16.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA A 124 LEU A 122 VAL A 151 THR A 149 ALA A 112	1.49A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA A 52 VAL A 24 VAL A 35 ALA A 124 ALA A 38	1.65A	16.81	AMP A 201 ( 4.0A) None None None AMP A 201 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA A 154 LEU A 153 VAL A 155 ALA A 134 ALA A 38	1.67A	16.81	AMP A 201 ( 4.5A) None AMP A 201 ( 4.4A) None AMP A 201 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 11	ALA A 154 LEU A 153 VAL A 155 ALA A 129 ALA A 38	1.53A		AMP A 201 ( 4.5A) None AMP A 201 ( 4.4A) AMP A 201 ( 3.4A) AMP A 201 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w6y	NSP3 (SARS-CoV-2)	5 / 10	ALA A 154 LEU A 153 VAL A 155 ALA A 134 ALA A 38	1.72A	16.81	AMP A 201 ( 4.5A) None AMP A 201 ( 4.4A) None AMP A 201 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w75	NSP16 (SARS-CoV-2)	5 / 11	LEU A6892 ILE A6926 THR A6880 ALA A6905 LEU A6887	1.56A	16.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w75	NSP16 (SARS-CoV-2)	5 / 11	LEU C6892 ILE C6926 THR C6880 ALA C6905 LEU C6887	1.52A	16.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w75	NSP16 (SARS-CoV-2)	5 / 10	LEU A6909 VAL A6916 PHE A6868 VAL A6894 ILE A6925	1.74A	16.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w75	NSP10 (SARS-CoV-2)	5 / 11	VAL B4369 THR B4368 ALA B4307 THR B4309 LEU B4345	1.57A	18.03	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w75	NSP16 (SARS-CoV-2)	5 / 10	LEU A7093 VAL C7086 VAL A7092 ILE C6866 LEU C6892	1.78A	16.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w75	NSP16 (SARS-CoV-2)	5 / 11	LEU A6909 VAL A6916 PHE A6868 VAL A6894 ILE A6925	1.80A	16.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w75	NSP16 (SARS-CoV-2)	5 / 11	LEU A7093 VAL C7086 VAL A7092 ILE C6866 LEU C6892	1.75A	16.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w75	NSP10 NSP16 (SARS-CoV-2)	5 / 10	ALA A6877 VAL B4295 VAL A6882 ILE A6838 ALA A6843	1.78A	16.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w75	NSP16 (SARS-CoV-2)	5 / 10	ALA A6960 LEU A6959 ALA A6986 THR A6856 LEU A7073	1.72A	16.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w75	NSP16 (SARS-CoV-2)	5 / 11	ALA C6960 LEU C6959 ALA C6986 THR C6856 LEU C7073	1.75A	16.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w75	NSP10 (SARS-CoV-2)	5 / 11	VAL D4369 THR D4368 ALA D4307 THR D4309 LEU D4345	1.56A	18.03	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w75	NSP16 (SARS-CoV-2)	5 / 10	ALA C6960 LEU C6959 ALA C6986 THR C6856 LEU C7073	1.70A	16.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w75	NSP16 (SARS-CoV-2)	5 / 10	LEU C6909 VAL C6916 PHE C6868 VAL C6894 ILE C6925	1.75A	16.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	5 / 11	ALA A 131 LEU A 132 ALA A 144 THR A 90 ALA A 149	1.40A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	ALA B 131 LEU B 132 ALA B 144 THR B 90 ALA B 149	1.34A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	5 / 11	ALA C 131 LEU C 132 ALA C 144 THR C 90 ALA C 149	1.37A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	ALA C 131 LEU C 132 ALA C 144 THR C 90 ALA C 149	1.39A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	5 / 10	ALA A 131 LEU A 132 ALA A 144 THR A 90 ALA A 149	1.41A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	5 / 11	ALA B 131 LEU B 132 ALA B 144 THR B 90 ALA B 149	1.32A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wcf	NSP3 (SARS-CoV-2)	5 / 10	ALA A 124 LEU A 123 VAL A 35 ALA A 56 LEU A 53	1.57A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wcf	NSP3 (SARS-CoV-2)	5 / 11	ALA A 154 LEU A 153 VAL A 155 ALA A 129 ALA A 38	1.48A		None None None None MES A 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wcf	NSP3 (SARS-CoV-2)	5 / 10	ALA A 154 LEU A 153 VAL A 155 ALA A 129 ALA A 38	1.48A		None None None None MES A 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wcf	NSP3 (SARS-CoV-2)	5 / 11	ALA A 38 VAL A 95 VAL A 77 ALA A 134 LEU A 127	1.49A		MES A 201 (-3.6A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wcf	NSP3 (SARS-CoV-2)	5 / 10	ALA A 124 VAL A 36 VAL A 49 ALA A 129 LEU A 127	1.47A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wen	NSP3 (SARS-CoV-2)	5 / 11	ALA A 124 LEU A 122 VAL A 151 THR A 149 ALA A 112	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wen	NSP3 (SARS-CoV-2)	5 / 11	ALA A 38 VAL A 95 VAL A 77 ALA A 134 LEU A 127	1.31A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wen	NSP3 (SARS-CoV-2)	5 / 11	ALA A 124 LEU A 123 VAL A 35 ALA A 56 LEU A 53	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wen	NSP3 (SARS-CoV-2)	5 / 10	ALA A 124 VAL A 36 VAL A 49 ALA A 129 LEU A 127	1.52A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wen	NSP3 (SARS-CoV-2)	5 / 10	ALA A 38 VAL A 95 VAL A 77 ALA A 134 LEU A 127	1.51A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wen	NSP3 (SARS-CoV-2)	5 / 10	ALA A 124 LEU A 123 VAL A 35 ALA A 56 LEU A 53	1.55A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wey	NSP3 (SARS-CoV-2)	5 / 10	ALA A 242 VAL A 299 VAL A 281 ALA A 338 LEU A 331	1.56A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wey	NSP3 (SARS-CoV-2)	5 / 10	ALA A 328 VAL A 240 VAL A 253 ALA A 333 LEU A 331	1.52A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wey	NSP3 (SARS-CoV-2)	5 / 11	ALA A 242 VAL A 299 VAL A 281 ALA A 338 LEU A 331	1.36A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wiq	NSP7 (SARS-CoV-2)	5 / 11	VAL A 11 VAL A 6 THR A 9 ALA A 42 LEU A 40	1.48A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 11	LEU A 143 PHE A 177 THR A 145 THR A 84 ALA A 82	1.48A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	ALA B 138 LEU B 134 VAL B 122 ILE B 108 ALA B 109	1.48A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	ALA A 138 LEU A 134 VAL A 122 ILE A 108 ALA A 109	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 11	LEU B 143 PHE B 177 THR B 145 THR B 84 ALA B 82	1.50A		None None ACT B 408 (-4.0A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	ALA B 138 PHE B 123 VAL B 78 ILE B 144 LEU B 143	1.48A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 11	ALA B 138 PHE B 123 VAL B 78 ILE B 144 LEU B 143	1.49A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 10	ALA A 138 PHE A 123 VAL A 78 ILE A 144 LEU A 143	1.51A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 11	ALA A 138 LEU A 134 VAL A 122 ILE A 108 ALA A 109	1.54A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 11	ALA B 138 LEU B 134 VAL B 122 ILE B 108 ALA B 109	1.49A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 11	ALA A 138 PHE A 123 VAL A 78 ILE A 144 LEU A 143	1.51A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	ALA B 52 LEU B 53 VAL B 24 VAL B 35 ALA B 124	1.57A		APR B 201 ( 4.1A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	ALA C 154 LEU C 153 VAL C 155 ALA C 129 ALA C 38	1.43A		APR C 201 (-4.5A) None None APR C 201 (-3.7A) APR C 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	ALA C 124 LEU C 123 VAL C 35 VAL C 30 ALA C 21	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	ALA A 124 LEU A 122 VAL A 151 THR A 149 ALA A 112	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	ALA C 154 LEU C 153 VAL C 155 ALA C 129 ALA C 38	1.44A		APR C 201 (-4.5A) None None APR C 201 (-3.7A) APR C 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	ALA A 154 LEU A 153 VAL A 155 ALA A 129 ALA A 38	1.44A		APR A 201 (-4.6A) None None APR A 201 (-3.7A) APR A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	ALA C 124 LEU C 122 VAL C 151 THR C 149 ALA C 112	1.51A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	ALA D 124 VAL D 36 VAL D 49 ALA D 129 LEU D 127	1.54A		None None APR D 201 (-3.6A) APR D 201 (-3.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	6 / 11	ALA D 52 LEU D 53 VAL D 24 VAL D 35 ALA D 124 ALA D 38	1.64A		APR D 201 ( 4.4A) None None None None APR D 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	ALA B 124 VAL B 36 VAL B 49 ALA B 129 LEU B 127	1.46A		None None APR B 201 (-3.7A) APR B 201 (-3.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	ALA A 124 LEU A 123 VAL A 35 VAL A 30 ALA A 21	1.54A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	ALA B 154 LEU B 153 VAL B 155 ALA B 129 ALA B 38	1.47A		APR B 201 (-4.6A) None None APR B 201 (-3.7A) APR B 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	ALA A 124 VAL A 36 VAL A 49 ALA A 129 LEU A 127	1.53A		None None APR A 201 (-3.8A) APR A 201 (-3.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	ALA B 154 LEU B 153 VAL B 155 ALA B 129 ALA B 38	1.47A		APR B 201 (-4.6A) None None APR B 201 (-3.7A) APR B 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	ALA D 154 LEU D 153 VAL D 155 ALA D 129 ALA D 38	1.45A		APR D 201 (-4.4A) None None APR D 201 (-3.7A) APR D 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	ALA A 124 VAL A 36 VAL A 49 ALA A 129 LEU A 127	1.48A		None None APR A 201 (-3.8A) APR A 201 (-3.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	ALA C 124 VAL C 36 VAL C 49 ALA C 129 LEU C 127	1.49A		None None APR C 201 (-3.8A) APR C 201 (-3.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	ALA B 124 LEU B 122 VAL B 151 THR B 149 ALA B 112	1.54A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	ALA B 124 VAL B 36 VAL B 49 ALA B 129 LEU B 127	1.52A		None None APR B 201 (-3.7A) APR B 201 (-3.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	ALA A 154 LEU A 153 VAL A 155 ALA A 129 ALA A 38	1.44A		APR A 201 (-4.6A) None None APR A 201 (-3.7A) APR A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	ALA D 124 VAL D 36 VAL D 49 ALA D 129 LEU D 127	1.48A		None None APR D 201 (-3.6A) APR D 201 (-3.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	ALA D 154 LEU D 153 VAL D 155 ALA D 129 ALA D 38	1.45A		APR D 201 (-4.4A) None None APR D 201 (-3.7A) APR D 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wqd	NSP7 NSP8 (SARS-CoV-2)	5 / 11	ALA D 86 THR D 93 ALA A 0 THR A 45 ALA A 48	1.48A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wqd	NSP7 (SARS-CoV-2)	5 / 11	VAL A 11 VAL A 6 THR A 9 ALA A 42 LEU A 40	1.50A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wqd	NSP7 (SARS-CoV-2)	5 / 11	VAL C 11 VAL C 6 THR C 9 ALA C 42 LEU C 40	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wqd	NSP7 NSP8 (SARS-CoV-2)	5 / 10	ALA B 102 LEU B 103 VAL A 53 VAL A 6 ALA A 42	1.56A		EDO B 302 ( 4.2A) None EDO B 302 ( 4.8A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wrh	PEPTIDASE C16 (SARS-CoV-2)	5 / 10	ALA A 131 LEU A 132 ALA A 144 THR A 90 ALA A 149	1.32A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6wrh	PEPTIDASE C16 (SARS-CoV-2)	5 / 11	ALA A 131 LEU A 132 ALA A 144 THR A 90 ALA A 149	1.32A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6y2g	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	6 / 11	LEU B 208 VAL B 212 ALA B 260 THR B 224 ALA B 266 LEU B 220	1.63A	20.74	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6yb7	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU A 205 VAL A 247 VAL A 202 ALA A 234 LEU A 227	1.67A	17.00	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6yb7	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 11	LEU A 208 VAL A 212 THR A 224 ALA A 266 LEU A 220	1.66A	17.00	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6yb7	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 10	LEU A 205 VAL A 261 VAL A 202 ALA A 234 LEU A 227	1.65A	17.00	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6yhu	REPLICASE POLYPROTEIN 1A (SARS-CoV-2)	5 / 11	VAL C 11 VAL C 6 THR C 9 ALA C 42 LEU C 40	1.47A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6yhu	REPLICASE POLYPROTEIN 1A (SARS-CoV-2)	5 / 11	VAL A 11 VAL A 6 THR A 9 ALA A 42 LEU A 40	1.48A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6yla	LIGHT CHAIN (Homo sapiens)	5 / 10	ALA C 150 LEU C 142 VAL C 202 ALA C 117 LEU C 207	1.54A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6yla	LIGHT CHAIN (Homo sapiens)	5 / 10	ALA L 150 LEU L 142 VAL L 202 ALA L 117 LEU L 207	1.52A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6yor	IGG L CHAIN (Homo sapiens)	5 / 10	ALA C 150 LEU C 142 VAL C 202 ALA C 117 LEU C 207	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6yor	IGG L CHAIN (Homo sapiens)	5 / 10	ALA L 150 LEU L 142 VAL L 202 ALA L 117 LEU L 207	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA D 124 VAL D 36 VAL D 49 ALA D 129 LEU D 127	1.51A		None None EDO D 209 (-4.6A) EDO D 205 (-4.5A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA B 124 VAL B 36 VAL B 49 ALA B 129 LEU B 127	1.44A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA E 124 VAL E 36 VAL E 49 ALA E 129 LEU E 127	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA B 124 LEU B 122 VAL B 151 THR B 149 ALA B 112	1.52A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA B 154 LEU B 153 VAL B 155 ALA B 129 ALA B 38	1.47A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA A 124 LEU A 122 VAL A 151 THR A 149 ALA A 112	1.53A		None None None EDO A 203 ( 4.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA C 154 LEU C 153 VAL C 155 ALA C 129 ALA C 38	1.47A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA C 154 LEU C 153 VAL C 155 ALA C 129 ALA C 38	1.47A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA C 124 VAL C 36 VAL C 49 ALA C 129 LEU C 127	1.49A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA A 52 VAL A 24 VAL A 35 ALA A 124 ALA A 38	1.58A		None None None None EDO A 202 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA E 154 LEU E 153 VAL E 155 ALA E 129 ALA E 38	1.45A		EDO E 205 (-4.4A) None EDO E 205 ( 4.2A) None EPE E 202 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA B 154 LEU B 153 VAL B 155 ALA B 129 ALA B 38	1.48A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA C 124 VAL C 36 VAL C 49 ALA C 129 LEU C 127	1.43A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA D 124 VAL D 36 VAL D 49 ALA D 129 LEU D 127	1.44A		None None EDO D 209 (-4.6A) EDO D 205 (-4.5A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA E 124 VAL E 36 VAL E 49 ALA E 129 LEU E 127	1.46A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA B 38 VAL B 95 VAL B 77 ALA B 134 LEU B 127	1.44A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA E 38 VAL E 95 VAL E 77 ALA E 134 LEU E 127	1.48A		EPE E 202 (-3.3A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA B 124 VAL B 36 VAL B 49 ALA B 129 LEU B 127	1.51A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA C 124 LEU C 123 VAL C 35 ALA C 56 LEU C 53	1.57A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA D 38 VAL D 95 VAL D 77 ALA D 134 LEU D 127	1.43A		EDO D 205 (-3.5A) None None EDO D 211 (-3.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA E 154 LEU E 153 VAL E 155 ALA E 129 ALA E 38	1.44A		EDO E 205 (-4.4A) None EDO E 205 ( 4.2A) None EPE E 202 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA A 124 VAL A 36 VAL A 49 ALA A 129 LEU A 127	1.45A		None None None None EDO A 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA B 52 LEU B 53 VAL B 24 VAL B 35 ALA B 124	1.58A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA D 124 LEU D 122 VAL D 151 THR D 149 ALA D 112	1.52A		None None None EDO D 203 ( 4.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA A 154 LEU A 153 VAL A 155 ALA A 129 ALA A 38	1.44A		None None None None EDO A 202 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA A 154 LEU A 153 VAL A 155 ALA A 129 ALA A 38	1.44A		None None None None EDO A 202 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA A 124 VAL A 36 VAL A 49 ALA A 129 LEU A 127	1.52A		None None APR A 201 (-3.7A) APR A 201 ( 3.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA D 124 VAL D 36 VAL D 49 ALA D 129 LEU D 127	1.51A		None None APR D 201 (-3.7A) APR D 201 (-3.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA B 154 LEU B 153 VAL B 155 ALA B 129 ALA B 38	1.45A		APR B 201 (-4.5A) None None APR B 201 (-3.6A) APR B 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA B 52 VAL B 24 VAL B 35 ALA B 124 ALA B 38	1.57A		APR B 201 ( 4.0A) None None None APR B 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA A 52 LEU A 53 VAL A 24 VAL A 35 ALA A 124	1.54A		APR A 201 ( 4.1A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA D 154 LEU D 153 VAL D 155 ALA D 129 ALA D 38	1.48A		APR D 201 (-4.5A) None None APR D 201 (-3.4A) APR D 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA A 124 VAL A 36 VAL A 49 ALA A 129 LEU A 127	1.45A		None None APR A 201 (-3.7A) APR A 201 ( 3.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA B 124 LEU B 122 VAL B 151 THR B 149 ALA B 112	1.51A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA E 52 LEU E 53 VAL E 24 VAL E 35 ALA E 124	1.56A		APR E 201 ( 4.1A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA E 124 VAL E 36 VAL E 49 ALA E 129 LEU E 127	1.51A		None None APR E 201 (-3.7A) APR E 201 (-3.5A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA E 154 LEU E 153 VAL E 155 ALA E 129 ALA E 38	1.48A		APR E 201 (-4.5A) None APR E 201 ( 4.9A) APR E 201 (-3.5A) APR E 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	6 / 11	ALA A 52 LEU A 53 VAL A 24 VAL A 35 ALA A 124 ALA A 38	1.62A		APR A 201 ( 4.1A) None None None None APR A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA D 124 LEU D 122 VAL D 151 THR D 149 ALA D 112	1.50A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA B 124 VAL B 36 VAL B 49 ALA B 129 LEU B 127	1.51A		None None APR B 201 (-3.7A) APR B 201 (-3.6A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA D 124 VAL D 36 VAL D 49 ALA D 129 LEU D 127	1.44A		None None APR D 201 (-3.7A) APR D 201 (-3.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA D 52 LEU D 53 VAL D 24 VAL D 35 ALA D 124	1.53A		EDO D 204 ( 3.7A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA E 124 VAL E 36 VAL E 49 ALA E 129 LEU E 127	1.44A		None None APR E 201 (-3.7A) APR E 201 (-3.5A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA B 124 VAL B 36 VAL B 49 ALA B 129 LEU B 127	1.43A		None None APR B 201 (-3.7A) APR B 201 (-3.6A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA E 52 VAL E 24 VAL E 35 ALA E 124 ALA E 38	1.57A		APR E 201 ( 4.1A) None None None APR E 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA B 52 LEU B 53 VAL B 24 VAL B 35 ALA B 124	1.55A		APR B 201 ( 4.0A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA A 154 LEU A 153 VAL A 155 ALA A 129 ALA A 38	1.46A		APR A 201 (-4.4A) None APR A 201 ( 4.8A) APR A 201 ( 3.7A) APR A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA A 124 LEU A 122 VAL A 151 THR A 149 ALA A 112	1.52A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA C 154 LEU C 153 VAL C 155 ALA C 129 ALA C 38	1.47A		APR C 201 (-4.5A) None APR C 201 ( 4.9A) APR C 201 (-3.6A) APR C 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA E 154 LEU E 153 VAL E 155 ALA E 129 ALA E 38	1.48A		APR E 201 (-4.5A) None APR E 201 ( 4.9A) APR E 201 (-3.5A) APR E 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA C 124 VAL C 36 VAL C 49 ALA C 129 LEU C 127	1.51A		None None APR C 201 (-3.6A) APR C 201 (-3.6A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA D 154 LEU D 153 VAL D 155 ALA D 129 ALA D 38	1.48A		APR D 201 (-4.5A) None None APR D 201 (-3.4A) APR D 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA B 154 LEU B 153 VAL B 155 ALA B 129 ALA B 38	1.46A		APR B 201 (-4.5A) None None APR B 201 (-3.6A) APR B 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA C 124 LEU C 122 VAL C 151 THR C 149 ALA C 112	1.54A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA A 52 VAL A 24 VAL A 35 ALA A 124 ALA A 38	1.56A		APR A 201 ( 4.1A) None None None APR A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA C 124 VAL C 36 VAL C 49 ALA C 129 LEU C 127	1.44A		None None APR C 201 (-3.6A) APR C 201 (-3.6A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA A 154 LEU A 153 VAL A 155 ALA A 129 ALA A 38	1.47A		APR A 201 (-4.4A) None APR A 201 ( 4.8A) APR A 201 ( 3.7A) APR A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA C 52 LEU C 53 VAL C 24 VAL C 35 ALA C 124	1.55A		APR C 201 ( 4.0A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA C 52 VAL C 24 VAL C 35 ALA C 124 ALA C 38	1.58A		APR C 201 ( 4.0A) None None None APR C 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA C 154 LEU C 153 VAL C 155 ALA C 129 ALA C 38	1.46A		APR C 201 (-4.5A) None APR C 201 ( 4.9A) APR C 201 (-3.6A) APR C 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA C 124 VAL C 36 VAL C 49 ALA C 129 LEU C 127	1.49A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA C 124 VAL C 36 VAL C 49 ALA C 129 LEU C 127	1.43A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA B 38 VAL B 95 VAL B 77 ALA B 134 LEU B 127	1.44A		None None None EDO B 204 (-3.8A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA A 154 LEU A 153 VAL A 155 ALA A 129 ALA A 38	1.49A		None None None None MES A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA A 154 LEU A 153 VAL A 155 ALA A 129 ALA A 38	1.49A		None None None None MES A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA A 124 VAL A 36 VAL A 49 ALA A 129 LEU A 127	1.49A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA C 124 LEU C 122 VAL C 151 THR C 149 ALA C 112	1.52A		None None None EDO C 204 ( 4.9A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA C 52 LEU C 53 VAL C 24 VAL C 35 ALA C 124	1.56A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA A 124 LEU A 122 VAL A 151 THR A 149 ALA A 112	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA B 124 LEU B 122 VAL B 151 THR B 149 ALA B 112	1.51A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA C 38 VAL C 95 VAL C 77 ALA C 134 LEU C 127	1.43A		MES C 201 (-3.5A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA A 124 VAL A 36 VAL A 49 ALA A 129 LEU A 127	1.43A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA B 124 VAL B 36 VAL B 49 ALA B 129 LEU B 127	1.46A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 10	ALA A 124 LEU A 123 VAL A 35 ALA A 56 LEU A 53	1.57A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA B 124 VAL B 36 VAL B 49 ALA B 129 LEU B 127	1.54A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 11	ALA A 38 VAL A 95 VAL A 77 ALA A 134 LEU A 127	1.49A		MES A 201 (-3.5A) None None EDO A 205 (-4.0A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7btf	NSP12 NSP8 (SARS-CoV-2)	5 / 10	ALA B 110 VAL B 115 VAL A 341 ALA A 383 ALA B 102	1.48A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7btf	NSP12 (SARS-CoV-2)	5 / 11	ALA A 97 LEU A 119 THR A 120 ALA A 125 THR A 206	1.50A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7btf	NSP12 (SARS-CoV-2)	5 / 10	ALA A 253 LEU A 251 THR A 189 ALA A 185 LEU A 187	1.45A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7btf	NSP12 (SARS-CoV-2)	5 / 10	ALA A 634 LEU A 638 VAL A 693 ILE A 589 ALA A 685	1.54A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7btf	NSP12 NSP8 (SARS-CoV-2)	5 / 10	ALA A 379 VAL A 341 ALA B 102 ALA B 125 LEU B 98	1.48A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7btf	NSP12 NSP7 (SARS-CoV-2)	5 / 10	LEU C 17 VAL C 58 ALA C 30 ALA A 443 LEU C 35	1.55A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7btf	NSP12 NSP8 (SARS-CoV-2)	6 / 10	ALA A 379 LEU B 117 VAL A 330 ILE B 106 ALA B 125 LEU B 103	1.66A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7btf	NSP12 (SARS-CoV-2)	5 / 11	ALA A 399 LEU A 673 PHE A 504 ALA A 376 ALA A 379	1.45A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7btf	NSP12 (SARS-CoV-2)	5 / 11	ALA A 253 LEU A 251 THR A 189 ALA A 185 LEU A 187	1.51A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7btf	NSP12 (SARS-CoV-2)	5 / 10	LEU A 241 VAL A 128 VAL A 182 ILE A 145 THR A 120	1.41A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7btf	NSP12 NSP8 (SARS-CoV-2)	5 / 11	ALA B 110 VAL B 115 VAL A 341 ALA A 383 ALA B 102	1.51A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7bv1	NSP12 NSP8 (SARS-CoV-2)	5 / 11	ALA A 375 PHE A 368 VAL B 83 THR B 84 ALA A 502	1.45A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7bv1	NSP12 NSP8 (SARS-CoV-2)	6 / 10	ALA A 379 LEU B 117 VAL A 330 ILE B 106 ALA B 125 LEU B 103	1.63A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	ALA A 253 LEU A 251 THR A 189 ALA A 185 LEU A 187	1.50A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7bv1	NSP12 (SARS-CoV-2)	5 / 10	ALA A 399 LEU A 673 PHE A 504 ALA A 376 ALA A 379	1.40A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7bv2	NSP12 NSP8 (SARS-CoV-2)	5 / 10	ALA A 379 VAL A 341 ALA B 102 ALA B 125 LEU B 98	1.55A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7bv2	NSP12 NSP8 (SARS-CoV-2)	6 / 10	ALA A 379 LEU B 117 VAL A 330 ILE B 106 ALA B 125 LEU B 103	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7bv2	NSP12 (SARS-CoV-2)	5 / 10	ALA A 634 LEU A 638 VAL A 693 ILE A 589 ALA A 685	1.41A		None None None None A T 11 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7bv2	NSP12 (SARS-CoV-2)	5 / 11	ALA A 253 LEU A 251 THR A 189 ALA A 185 LEU A 187	1.52A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7bv2	NSP12 (SARS-CoV-2)	5 / 10	LEU A 127 VAL A 182 ALA A 250 ALA A 176 LEU A 247	1.57A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7bv2	NSP12 (SARS-CoV-2)	5 / 10	ALA A 253 LEU A 251 THR A 189 ALA A 185 LEU A 187	1.47A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7bv2	NSP12 (SARS-CoV-2)	5 / 11	ALA A 634 LEU A 638 VAL A 693 ILE A 589 ALA A 685	1.49A		None None None None A T 11 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_B_FJQB501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	7bv2	NSP12 (SARS-CoV-2)	5 / 11	ALA A 97 LEU A 119 THR A 120 ALA A 125 THR A 206	1.53A		None