Ligand ID: FJQ


Drugbank ID:
DB01007
(Tioconazole)


Indication:
For the local treatment of vulvovaginal candidiasis (moniliasis).

Get human targets for FJQ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'FJQ' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 10
LEU A 205
VAL A 261
VAL A 202
ALA A 234
LEU A 227
1.65A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 10
LEU A 205
VAL A 247
VAL A 202
ALA A 234
LEU A 227
1.68A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
LEU A 208
VAL A 212
THR A 224
ALA A 266
LEU A 220
1.65A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 11
LEU A 208
VAL A 212
THR A 224
ALA A 266
LEU A 220
1.53A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 10
VAL A 212
ALA A 260
THR A 224
ALA A 266
LEU A 220
1.54A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		5 / 10
LEU A 786
VAL A 792
ALA A 625
THR A 680
LEU A 630
1.51A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		5 / 11
ALA A  97
LEU A 119
THR A 120
ALA A 125
THR A 206
1.50A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		5 / 11
ALA A 253
LEU A 251
THR A 189
ALA A 185
LEU A 187
1.53A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		5 / 10
ALA A 634
LEU A 638
VAL A 693
ILE A 589
ALA A 685
1.54A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		5 / 10
LEU A 241
VAL A 128
VAL A 182
ILE A 145
THR A 120
1.40A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		5 / 10
ALA A 253
LEU A 251
THR A 189
ALA A 185
LEU A 187
1.48A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 11
LEU C 858
VAL C 736
VAL C 860
THR C 859
ILE C 770
ALA C 958
1.72A16.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		5 / 10
ALA A 154
LEU A 153
VAL A 155
ALA A 129
ALA A  38
1.37A
None
None
SO4  A 203 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		5 / 10
ALA B 124
VAL B  36
VAL B  49
ALA B 129
LEU B 127
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		5 / 11
ALA A 154
LEU A 153
VAL A 155
ALA A 129
ALA A  38
1.38A
None
None
SO4  A 203 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		5 / 10
ALA A  52
LEU A  53
VAL A  24
VAL A  35
ALA A 124
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		5 / 10
ALA B 124
LEU B 123
VAL B  35
VAL B  30
ALA B  21
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		5 / 11
ALA A 124
LEU A 122
VAL A 151
THR A 149
ALA A 112
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		5 / 10
ALA A 124
VAL A  36
VAL A  49
ALA A 129
LEU A 127
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		5 / 11
ALA B 154
LEU B 153
VAL B 155
ALA B 129
ALA B  38
1.35A
None
None
SO4  B 204 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		5 / 10
ALA B 154
LEU B 153
VAL B 155
ALA B 129
ALA B  38
1.34A
None
None
SO4  B 204 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		5 / 11
ALA A  38
VAL A  95
VAL A  77
ALA A 134
LEU A 127
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		6 / 11
ALA A  52
LEU A  53
VAL A  24
VAL A  35
ALA A 124
ALA A  38
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		5 / 10
ALA A  52
VAL A  24
VAL A  35
ALA A 124
ALA A  38
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		5 / 11
ALA B 124
LEU B 123
VAL B  35
VAL B  30
ALA B  21
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		6 / 11
ALA B  52
LEU B  53
VAL B  24
VAL B  35
ALA B 124
ALA B  38
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 11
ALA C 419
LEU C 425
PHE C 400
VAL C 512
THR C 376
1.74A16.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 10
ALA C 419
LEU C 425
PHE C 400
VAL C 512
THR C 376
1.74A16.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
ALA A6960
LEU A6959
ALA A6986
ALA A6858
LEU A7073
1.67A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
LEU A6909
PHE A6868
VAL A6894
ILE A6925
ALA A6919
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ALA A6960
LEU A6959
ALA A6986
THR A6856
LEU A7073
1.76A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
LEU A6887
THR A6891
THR A7055
ALA A6858
LEU A7052
1.77A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
LEU A6887
VAL A6865
THR A6891
ALA A6905
ALA A6881
1.80A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
LEU A6909
VAL A6916
PHE A6868
VAL A6894
ILE A6925
1.74A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w61 NSP10
(SARS-CoV-2)		5 / 11
VAL B4369
THR B4368
ALA B4307
THR B4309
LEU B4345
1.56A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 10
ALA A6877
VAL B4295
VAL A6882
ILE A6838
ALA A6843
1.78A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ALA A6858
LEU A6857
ILE A6925
ALA A6966
LEU A6959
1.78A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
LEU A6909
PHE A6868
VAL A6894
ILE A6925
ALA A6919
1.67A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
ALA A  52
VAL A  24
VAL A  35
ALA A 124
ALA A  38
1.65A16.81
AMP  A 201 ( 4.0A)
None
None
None
AMP  A 201 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA B 154
LEU B 153
VAL B 155
ALA B 134
ALA B  38
1.66A16.81
None
None
None
None
MES  B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
ALA B 154
LEU B 153
VAL B 155
ALA B 129
ALA B  38
1.52A
None
None
None
None
MES  B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA A  38
VAL A  95
VAL A  77
ALA A 134
LEU A 127
1.43A
AMP  A 201 ( 3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
ALA A 124
LEU A 123
VAL A  35
VAL A  30
ALA A  21
1.61A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
ALA B  52
VAL B  24
VAL B  35
ALA B 124
ALA B  38
1.62A16.81
None
None
None
None
MES  B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
ALA A 124
LEU A 123
VAL A  35
ALA A  56
LEU A  53
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
ALA A 124
VAL A  36
VAL A  49
ALA A 129
LEU A 127
1.47A
None
None
AMP  A 201 ( 3.7A)
AMP  A 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA B 124
LEU B 123
VAL B  35
ALA B  56
LEU B  53
1.55A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
ALA B  56
LEU B  88
VAL B  24
VAL B  35
ALA B 124
1.73A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA B 124
LEU B 122
VAL B 151
THR B 149
ALA B 112
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA B  52
LEU B  53
VAL B  24
VAL B  35
ALA B 124
1.67A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA B  52
VAL B  24
VAL B  35
ALA B 124
ALA B  38
1.64A16.81
None
None
None
None
MES  B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA A 124
LEU A 123
VAL A  35
ALA A  56
LEU A  53
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
ALA A  56
LEU A  88
VAL A  24
VAL A  35
ALA A 124
1.76A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA A 124
VAL A  36
VAL A  49
ALA A 129
LEU A 127
1.53A
None
None
AMP  A 201 ( 3.7A)
AMP  A 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA A 124
LEU A 123
VAL A  35
VAL A  30
ALA A  21
1.55A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
LEU A 160
VAL A 155
ALA A  38
ALA A 134
LEU A 126
1.80A16.81
None
AMP  A 201 ( 4.4A)
AMP  A 201 ( 3.9A)
None
AMP  A 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA B 124
LEU B 123
VAL B  35
VAL B  30
ALA B  21
1.56A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA B 154
LEU B 153
VAL B 155
ALA B 129
ALA B  38
1.51A
None
None
None
None
MES  B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
ALA B 124
LEU B 123
VAL B  35
ALA B  56
LEU B  53
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
ALA B 124
VAL B  36
VAL B  49
ALA B 129
LEU B 127
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA A  52
LEU A  53
VAL A  24
VAL A  35
ALA A 124
1.66A16.81
AMP  A 201 ( 4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA B 124
VAL B  36
VAL B  49
ALA B 129
LEU B 127
1.55A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA B  38
VAL B  95
VAL B  77
ALA B 134
LEU B 127
1.42A
MES  B 201 ( 3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
ALA B 124
LEU B 123
VAL B  35
VAL B  30
ALA B  21
1.63A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA A 124
LEU A 122
VAL A 151
THR A 149
ALA A 112
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA A  52
VAL A  24
VAL A  35
ALA A 124
ALA A  38
1.65A16.81
AMP  A 201 ( 4.0A)
None
None
None
AMP  A 201 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA A 154
LEU A 153
VAL A 155
ALA A 134
ALA A  38
1.67A16.81
AMP  A 201 ( 4.5A)
None
AMP  A 201 ( 4.4A)
None
AMP  A 201 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA A 154
LEU A 153
VAL A 155
ALA A 129
ALA A  38
1.53A
AMP  A 201 ( 4.5A)
None
AMP  A 201 ( 4.4A)
AMP  A 201 ( 3.4A)
AMP  A 201 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
ALA A 154
LEU A 153
VAL A 155
ALA A 134
ALA A  38
1.72A16.81
AMP  A 201 ( 4.5A)
None
AMP  A 201 ( 4.4A)
None
AMP  A 201 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		5 / 11
LEU A6892
ILE A6926
THR A6880
ALA A6905
LEU A6887
1.56A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		5 / 11
LEU C6892
ILE C6926
THR C6880
ALA C6905
LEU C6887
1.52A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		5 / 10
LEU A6909
VAL A6916
PHE A6868
VAL A6894
ILE A6925
1.74A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w75 NSP10
(SARS-CoV-2)		5 / 11
VAL B4369
THR B4368
ALA B4307
THR B4309
LEU B4345
1.57A18.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		5 / 10
LEU A7093
VAL C7086
VAL A7092
ILE C6866
LEU C6892
1.78A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		5 / 11
LEU A6909
VAL A6916
PHE A6868
VAL A6894
ILE A6925
1.80A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		5 / 11
LEU A7093
VAL C7086
VAL A7092
ILE C6866
LEU C6892
1.75A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 10
ALA A6877
VAL B4295
VAL A6882
ILE A6838
ALA A6843
1.78A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ALA A6960
LEU A6959
ALA A6986
THR A6856
LEU A7073
1.72A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		5 / 11
ALA C6960
LEU C6959
ALA C6986
THR C6856
LEU C7073
1.75A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w75 NSP10
(SARS-CoV-2)		5 / 11
VAL D4369
THR D4368
ALA D4307
THR D4309
LEU D4345
1.56A18.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ALA C6960
LEU C6959
ALA C6986
THR C6856
LEU C7073
1.70A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		5 / 10
LEU C6909
VAL C6916
PHE C6868
VAL C6894
ILE C6925
1.75A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
ALA A 131
LEU A 132
ALA A 144
THR A  90
ALA A 149
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 10
ALA B 131
LEU B 132
ALA B 144
THR B  90
ALA B 149
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
ALA C 131
LEU C 132
ALA C 144
THR C  90
ALA C 149
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 10
ALA C 131
LEU C 132
ALA C 144
THR C  90
ALA C 149
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 10
ALA A 131
LEU A 132
ALA A 144
THR A  90
ALA A 149
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
ALA B 131
LEU B 132
ALA B 144
THR B  90
ALA B 149
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		5 / 10
ALA A 124
LEU A 123
VAL A  35
ALA A  56
LEU A  53
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		5 / 11
ALA A 154
LEU A 153
VAL A 155
ALA A 129
ALA A  38
1.48A
None
None
None
None
MES  A 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		5 / 10
ALA A 154
LEU A 153
VAL A 155
ALA A 129
ALA A  38
1.48A
None
None
None
None
MES  A 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		5 / 11
ALA A  38
VAL A  95
VAL A  77
ALA A 134
LEU A 127
1.49A
MES  A 201 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		5 / 10
ALA A 124
VAL A  36
VAL A  49
ALA A 129
LEU A 127
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wen NSP3
(SARS-CoV-2)		5 / 11
ALA A 124
LEU A 122
VAL A 151
THR A 149
ALA A 112
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wen NSP3
(SARS-CoV-2)		5 / 11
ALA A  38
VAL A  95
VAL A  77
ALA A 134
LEU A 127
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wen NSP3
(SARS-CoV-2)		5 / 11
ALA A 124
LEU A 123
VAL A  35
ALA A  56
LEU A  53
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wen NSP3
(SARS-CoV-2)		5 / 10
ALA A 124
VAL A  36
VAL A  49
ALA A 129
LEU A 127
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wen NSP3
(SARS-CoV-2)		5 / 10
ALA A  38
VAL A  95
VAL A  77
ALA A 134
LEU A 127
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wen NSP3
(SARS-CoV-2)		5 / 10
ALA A 124
LEU A 123
VAL A  35
ALA A  56
LEU A  53
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wey NSP3
(SARS-CoV-2)		5 / 10
ALA A 242
VAL A 299
VAL A 281
ALA A 338
LEU A 331
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wey NSP3
(SARS-CoV-2)		5 / 10
ALA A 328
VAL A 240
VAL A 253
ALA A 333
LEU A 331
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wey NSP3
(SARS-CoV-2)		5 / 11
ALA A 242
VAL A 299
VAL A 281
ALA A 338
LEU A 331
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wiq NSP7
(SARS-CoV-2)		5 / 11
VAL A  11
VAL A   6
THR A   9
ALA A  42
LEU A  40
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
LEU A 143
PHE A 177
THR A 145
THR A  84
ALA A  82
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ALA B 138
LEU B 134
VAL B 122
ILE B 108
ALA B 109
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ALA A 138
LEU A 134
VAL A 122
ILE A 108
ALA A 109
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
LEU B 143
PHE B 177
THR B 145
THR B  84
ALA B  82
1.50A
None
None
ACT  B 408 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ALA B 138
PHE B 123
VAL B  78
ILE B 144
LEU B 143
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
ALA B 138
PHE B 123
VAL B  78
ILE B 144
LEU B 143
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
ALA A 138
PHE A 123
VAL A  78
ILE A 144
LEU A 143
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
ALA A 138
LEU A 134
VAL A 122
ILE A 108
ALA A 109
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
ALA B 138
LEU B 134
VAL B 122
ILE B 108
ALA B 109
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
ALA A 138
PHE A 123
VAL A  78
ILE A 144
LEU A 143
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
ALA B  52
LEU B  53
VAL B  24
VAL B  35
ALA B 124
1.57A
APR  B 201 ( 4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
ALA C 154
LEU C 153
VAL C 155
ALA C 129
ALA C  38
1.43A
APR  C 201 (-4.5A)
None
None
APR  C 201 (-3.7A)
APR  C 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA C 124
LEU C 123
VAL C  35
VAL C  30
ALA C  21
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA A 124
LEU A 122
VAL A 151
THR A 149
ALA A 112
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA C 154
LEU C 153
VAL C 155
ALA C 129
ALA C  38
1.44A
APR  C 201 (-4.5A)
None
None
APR  C 201 (-3.7A)
APR  C 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
ALA A 154
LEU A 153
VAL A 155
ALA A 129
ALA A  38
1.44A
APR  A 201 (-4.6A)
None
None
APR  A 201 (-3.7A)
APR  A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA C 124
LEU C 122
VAL C 151
THR C 149
ALA C 112
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA D 124
VAL D  36
VAL D  49
ALA D 129
LEU D 127
1.54A
None
None
APR  D 201 (-3.6A)
APR  D 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 11
ALA D  52
LEU D  53
VAL D  24
VAL D  35
ALA D 124
ALA D  38
1.64A
APR  D 201 ( 4.4A)
None
None
None
None
APR  D 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
ALA B 124
VAL B  36
VAL B  49
ALA B 129
LEU B 127
1.46A
None
None
APR  B 201 (-3.7A)
APR  B 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA A 124
LEU A 123
VAL A  35
VAL A  30
ALA A  21
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA B 154
LEU B 153
VAL B 155
ALA B 129
ALA B  38
1.47A
APR  B 201 (-4.6A)
None
None
APR  B 201 (-3.7A)
APR  B 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA A 124
VAL A  36
VAL A  49
ALA A 129
LEU A 127
1.53A
None
None
APR  A 201 (-3.8A)
APR  A 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
ALA B 154
LEU B 153
VAL B 155
ALA B 129
ALA B  38
1.47A
APR  B 201 (-4.6A)
None
None
APR  B 201 (-3.7A)
APR  B 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA D 154
LEU D 153
VAL D 155
ALA D 129
ALA D  38
1.45A
APR  D 201 (-4.4A)
None
None
APR  D 201 (-3.7A)
APR  D 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
ALA A 124
VAL A  36
VAL A  49
ALA A 129
LEU A 127
1.48A
None
None
APR  A 201 (-3.8A)
APR  A 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
ALA C 124
VAL C  36
VAL C  49
ALA C 129
LEU C 127
1.49A
None
None
APR  C 201 (-3.8A)
APR  C 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA B 124
LEU B 122
VAL B 151
THR B 149
ALA B 112
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA B 124
VAL B  36
VAL B  49
ALA B 129
LEU B 127
1.52A
None
None
APR  B 201 (-3.7A)
APR  B 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA A 154
LEU A 153
VAL A 155
ALA A 129
ALA A  38
1.44A
APR  A 201 (-4.6A)
None
None
APR  A 201 (-3.7A)
APR  A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
ALA D 124
VAL D  36
VAL D  49
ALA D 129
LEU D 127
1.48A
None
None
APR  D 201 (-3.6A)
APR  D 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
ALA D 154
LEU D 153
VAL D 155
ALA D 129
ALA D  38
1.45A
APR  D 201 (-4.4A)
None
None
APR  D 201 (-3.7A)
APR  D 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
ALA D  86
THR D  93
ALA A   0
THR A  45
ALA A  48
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wqd NSP7
(SARS-CoV-2)		5 / 11
VAL A  11
VAL A   6
THR A   9
ALA A  42
LEU A  40
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wqd NSP7
(SARS-CoV-2)		5 / 11
VAL C  11
VAL C   6
THR C   9
ALA C  42
LEU C  40
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
ALA B 102
LEU B 103
VAL A  53
VAL A   6
ALA A  42
1.56A
EDO  B 302 ( 4.2A)
None
EDO  B 302 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 10
ALA A 131
LEU A 132
ALA A 144
THR A  90
ALA A 149
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 11
ALA A 131
LEU A 132
ALA A 144
THR A  90
ALA A 149
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 11
LEU B 208
VAL B 212
ALA B 260
THR B 224
ALA B 266
LEU B 220
1.63A20.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU A 205
VAL A 247
VAL A 202
ALA A 234
LEU A 227
1.67A17.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU A 208
VAL A 212
THR A 224
ALA A 266
LEU A 220
1.66A17.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
LEU A 205
VAL A 261
VAL A 202
ALA A 234
LEU A 227
1.65A17.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
VAL C  11
VAL C   6
THR C   9
ALA C  42
LEU C  40
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
VAL A  11
VAL A   6
THR A   9
ALA A  42
LEU A  40
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA D 124
VAL D  36
VAL D  49
ALA D 129
LEU D 127
1.51A
None
None
EDO  D 209 (-4.6A)
EDO  D 205 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA B 124
VAL B  36
VAL B  49
ALA B 129
LEU B 127
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA E 124
VAL E  36
VAL E  49
ALA E 129
LEU E 127
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA B 124
LEU B 122
VAL B 151
THR B 149
ALA B 112
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA B 154
LEU B 153
VAL B 155
ALA B 129
ALA B  38
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA A 124
LEU A 122
VAL A 151
THR A 149
ALA A 112
1.53A
None
None
None
EDO  A 203 ( 4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA C 154
LEU C 153
VAL C 155
ALA C 129
ALA C  38
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA C 154
LEU C 153
VAL C 155
ALA C 129
ALA C  38
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA C 124
VAL C  36
VAL C  49
ALA C 129
LEU C 127
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA A  52
VAL A  24
VAL A  35
ALA A 124
ALA A  38
1.58A
None
None
None
None
EDO  A 202 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA E 154
LEU E 153
VAL E 155
ALA E 129
ALA E  38
1.45A
EDO  E 205 (-4.4A)
None
EDO  E 205 ( 4.2A)
None
EPE  E 202 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA B 154
LEU B 153
VAL B 155
ALA B 129
ALA B  38
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA C 124
VAL C  36
VAL C  49
ALA C 129
LEU C 127
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA D 124
VAL D  36
VAL D  49
ALA D 129
LEU D 127
1.44A
None
None
EDO  D 209 (-4.6A)
EDO  D 205 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA E 124
VAL E  36
VAL E  49
ALA E 129
LEU E 127
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA B  38
VAL B  95
VAL B  77
ALA B 134
LEU B 127
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA E  38
VAL E  95
VAL E  77
ALA E 134
LEU E 127
1.48A
EPE  E 202 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA B 124
VAL B  36
VAL B  49
ALA B 129
LEU B 127
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA C 124
LEU C 123
VAL C  35
ALA C  56
LEU C  53
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA D  38
VAL D  95
VAL D  77
ALA D 134
LEU D 127
1.43A
EDO  D 205 (-3.5A)
None
None
EDO  D 211 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA E 154
LEU E 153
VAL E 155
ALA E 129
ALA E  38
1.44A
EDO  E 205 (-4.4A)
None
EDO  E 205 ( 4.2A)
None
EPE  E 202 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA A 124
VAL A  36
VAL A  49
ALA A 129
LEU A 127
1.45A
None
None
None
None
EDO  A 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA B  52
LEU B  53
VAL B  24
VAL B  35
ALA B 124
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA D 124
LEU D 122
VAL D 151
THR D 149
ALA D 112
1.52A
None
None
None
EDO  D 203 ( 4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA A 154
LEU A 153
VAL A 155
ALA A 129
ALA A  38
1.44A
None
None
None
None
EDO  A 202 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA A 154
LEU A 153
VAL A 155
ALA A 129
ALA A  38
1.44A
None
None
None
None
EDO  A 202 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA A 124
VAL A  36
VAL A  49
ALA A 129
LEU A 127
1.52A
None
None
APR  A 201 (-3.7A)
APR  A 201 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA D 124
VAL D  36
VAL D  49
ALA D 129
LEU D 127
1.51A
None
None
APR  D 201 (-3.7A)
APR  D 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA B 154
LEU B 153
VAL B 155
ALA B 129
ALA B  38
1.45A
APR  B 201 (-4.5A)
None
None
APR  B 201 (-3.6A)
APR  B 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA B  52
VAL B  24
VAL B  35
ALA B 124
ALA B  38
1.57A
APR  B 201 ( 4.0A)
None
None
None
APR  B 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA A  52
LEU A  53
VAL A  24
VAL A  35
ALA A 124
1.54A
APR  A 201 ( 4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA D 154
LEU D 153
VAL D 155
ALA D 129
ALA D  38
1.48A
APR  D 201 (-4.5A)
None
None
APR  D 201 (-3.4A)
APR  D 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA A 124
VAL A  36
VAL A  49
ALA A 129
LEU A 127
1.45A
None
None
APR  A 201 (-3.7A)
APR  A 201 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA B 124
LEU B 122
VAL B 151
THR B 149
ALA B 112
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA E  52
LEU E  53
VAL E  24
VAL E  35
ALA E 124
1.56A
APR  E 201 ( 4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA E 124
VAL E  36
VAL E  49
ALA E 129
LEU E 127
1.51A
None
None
APR  E 201 (-3.7A)
APR  E 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA E 154
LEU E 153
VAL E 155
ALA E 129
ALA E  38
1.48A
APR  E 201 (-4.5A)
None
APR  E 201 ( 4.9A)
APR  E 201 (-3.5A)
APR  E 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 11
ALA A  52
LEU A  53
VAL A  24
VAL A  35
ALA A 124
ALA A  38
1.62A
APR  A 201 ( 4.1A)
None
None
None
None
APR  A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA D 124
LEU D 122
VAL D 151
THR D 149
ALA D 112
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA B 124
VAL B  36
VAL B  49
ALA B 129
LEU B 127
1.51A
None
None
APR  B 201 (-3.7A)
APR  B 201 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA D 124
VAL D  36
VAL D  49
ALA D 129
LEU D 127
1.44A
None
None
APR  D 201 (-3.7A)
APR  D 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA D  52
LEU D  53
VAL D  24
VAL D  35
ALA D 124
1.53A
EDO  D 204 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA E 124
VAL E  36
VAL E  49
ALA E 129
LEU E 127
1.44A
None
None
APR  E 201 (-3.7A)
APR  E 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA B 124
VAL B  36
VAL B  49
ALA B 129
LEU B 127
1.43A
None
None
APR  B 201 (-3.7A)
APR  B 201 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA E  52
VAL E  24
VAL E  35
ALA E 124
ALA E  38
1.57A
APR  E 201 ( 4.1A)
None
None
None
APR  E 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA B  52
LEU B  53
VAL B  24
VAL B  35
ALA B 124
1.55A
APR  B 201 ( 4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA A 154
LEU A 153
VAL A 155
ALA A 129
ALA A  38
1.46A
APR  A 201 (-4.4A)
None
APR  A 201 ( 4.8A)
APR  A 201 ( 3.7A)
APR  A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA A 124
LEU A 122
VAL A 151
THR A 149
ALA A 112
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA C 154
LEU C 153
VAL C 155
ALA C 129
ALA C  38
1.47A
APR  C 201 (-4.5A)
None
APR  C 201 ( 4.9A)
APR  C 201 (-3.6A)
APR  C 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA E 154
LEU E 153
VAL E 155
ALA E 129
ALA E  38
1.48A
APR  E 201 (-4.5A)
None
APR  E 201 ( 4.9A)
APR  E 201 (-3.5A)
APR  E 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA C 124
VAL C  36
VAL C  49
ALA C 129
LEU C 127
1.51A
None
None
APR  C 201 (-3.6A)
APR  C 201 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA D 154
LEU D 153
VAL D 155
ALA D 129
ALA D  38
1.48A
APR  D 201 (-4.5A)
None
None
APR  D 201 (-3.4A)
APR  D 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA B 154
LEU B 153
VAL B 155
ALA B 129
ALA B  38
1.46A
APR  B 201 (-4.5A)
None
None
APR  B 201 (-3.6A)
APR  B 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA C 124
LEU C 122
VAL C 151
THR C 149
ALA C 112
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA A  52
VAL A  24
VAL A  35
ALA A 124
ALA A  38
1.56A
APR  A 201 ( 4.1A)
None
None
None
APR  A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA C 124
VAL C  36
VAL C  49
ALA C 129
LEU C 127
1.44A
None
None
APR  C 201 (-3.6A)
APR  C 201 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA A 154
LEU A 153
VAL A 155
ALA A 129
ALA A  38
1.47A
APR  A 201 (-4.4A)
None
APR  A 201 ( 4.8A)
APR  A 201 ( 3.7A)
APR  A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA C  52
LEU C  53
VAL C  24
VAL C  35
ALA C 124
1.55A
APR  C 201 ( 4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA C  52
VAL C  24
VAL C  35
ALA C 124
ALA C  38
1.58A
APR  C 201 ( 4.0A)
None
None
None
APR  C 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA C 154
LEU C 153
VAL C 155
ALA C 129
ALA C  38
1.46A
APR  C 201 (-4.5A)
None
APR  C 201 ( 4.9A)
APR  C 201 (-3.6A)
APR  C 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA C 124
VAL C  36
VAL C  49
ALA C 129
LEU C 127
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA C 124
VAL C  36
VAL C  49
ALA C 129
LEU C 127
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA B  38
VAL B  95
VAL B  77
ALA B 134
LEU B 127
1.44A
None
None
None
EDO  B 204 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA A 154
LEU A 153
VAL A 155
ALA A 129
ALA A  38
1.49A
None
None
None
None
MES  A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA A 154
LEU A 153
VAL A 155
ALA A 129
ALA A  38
1.49A
None
None
None
None
MES  A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA A 124
VAL A  36
VAL A  49
ALA A 129
LEU A 127
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA C 124
LEU C 122
VAL C 151
THR C 149
ALA C 112
1.52A
None
None
None
EDO  C 204 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA C  52
LEU C  53
VAL C  24
VAL C  35
ALA C 124
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA A 124
LEU A 122
VAL A 151
THR A 149
ALA A 112
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA B 124
LEU B 122
VAL B 151
THR B 149
ALA B 112
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA C  38
VAL C  95
VAL C  77
ALA C 134
LEU C 127
1.43A
MES  C 201 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA A 124
VAL A  36
VAL A  49
ALA A 129
LEU A 127
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA B 124
VAL B  36
VAL B  49
ALA B 129
LEU B 127
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ALA A 124
LEU A 123
VAL A  35
ALA A  56
LEU A  53
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA B 124
VAL B  36
VAL B  49
ALA B 129
LEU B 127
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA A  38
VAL A  95
VAL A  77
ALA A 134
LEU A 127
1.49A
MES  A 201 (-3.5A)
None
None
EDO  A 205 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 10
ALA B 110
VAL B 115
VAL A 341
ALA A 383
ALA B 102
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 11
ALA A  97
LEU A 119
THR A 120
ALA A 125
THR A 206
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 10
ALA A 253
LEU A 251
THR A 189
ALA A 185
LEU A 187
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 10
ALA A 634
LEU A 638
VAL A 693
ILE A 589
ALA A 685
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 10
ALA A 379
VAL A 341
ALA B 102
ALA B 125
LEU B  98
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 10
LEU C  17
VAL C  58
ALA C  30
ALA A 443
LEU C  35
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7btf NSP12
NSP8
(SARS-CoV-2)		6 / 10
ALA A 379
LEU B 117
VAL A 330
ILE B 106
ALA B 125
LEU B 103
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 11
ALA A 399
LEU A 673
PHE A 504
ALA A 376
ALA A 379
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 11
ALA A 253
LEU A 251
THR A 189
ALA A 185
LEU A 187
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 10
LEU A 241
VAL A 128
VAL A 182
ILE A 145
THR A 120
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 11
ALA B 110
VAL B 115
VAL A 341
ALA A 383
ALA B 102
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 11
ALA A 375
PHE A 368
VAL B  83
THR B  84
ALA A 502
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		6 / 10
ALA A 379
LEU B 117
VAL A 330
ILE B 106
ALA B 125
LEU B 103
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
ALA A 253
LEU A 251
THR A 189
ALA A 185
LEU A 187
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
ALA A 399
LEU A 673
PHE A 504
ALA A 376
ALA A 379
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 10
ALA A 379
VAL A 341
ALA B 102
ALA B 125
LEU B  98
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		6 / 10
ALA A 379
LEU B 117
VAL A 330
ILE B 106
ALA B 125
LEU B 103
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
ALA A 634
LEU A 638
VAL A 693
ILE A 589
ALA A 685
1.41A
None
None
None
None
A  T  11 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
ALA A 253
LEU A 251
THR A 189
ALA A 185
LEU A 187
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
LEU A 127
VAL A 182
ALA A 250
ALA A 176
LEU A 247
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
ALA A 253
LEU A 251
THR A 189
ALA A 185
LEU A 187
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
ALA A 634
LEU A 638
VAL A 693
ILE A 589
ALA A 685
1.49A
None
None
None
None
A  T  11 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
ALA A  97
LEU A 119
THR A 120
ALA A 125
THR A 206
1.53A
None