Ligand ID: CFX


Drugbank ID:
DB01331
(Cefoxitin)


Indication:
For the treatment of serious infections caused by susceptible strains microorganisms.

Get human targets for CFX in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'CFX'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		3 / 3
SER B 147
SER B 144
HIS B 164
1.11A23.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.00A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 123
ASN A 142
ASN A  28
GLY A 124
ALA A 116
1.49A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 123
ASN A 142
ASN A  28
GLY A 124
ALA A 116
1.51A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER D 919
GLU D 918
ASN E1173
THR E 923
ALA E1171
1.71A20.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER B 924
ASN F1154
THR A 922
GLY B 928
ASP B 932
1.44A23.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER D 919
GLU D 918
ASN E1173
THR E 923
ALA E1171
1.69A20.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B   0
ASN B 214
GLY B  -1
GLY B 215
ASP B 216
1.64A22.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B1147
SER B1144
HIS B1164
1.27A22.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 116
SER A 123
GLY B1002
LEU A 141
GLY A 124
1.45A22.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO B1052
LEU B1057
THR B1024
1.00A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER I  24
ASN H  20
THR G  22
GLY I  28
ASP I  32
1.40A12.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		3 / 3
SER A 147
SER A 144
HIS A 164
1.15A22.28
None
AZP  A 307 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
SER B 147
ASN B 119
SER B 144
GLY B 146
GLY B  29
1.64A20.81
None
None
AZP  B 307 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
SER B 147
ASN B 119
SER B 144
GLY B 146
GLY B  29
1.64A20.81
None
None
AZP  B 307 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.99A22.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
ASN B 222
SER B 310
GLU B 286
ASN D 281
GLY B 315
1.76A20.00
GOL  B1004 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
ALA B 294
ASN B 299
SER B 262
GLY B 260
ALA B 293
1.67A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		3 / 3
PRO A   2
LEU A   3
THR D  14
1.00A14.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		5 / 12
ALA G 155
SER G 156
ASN G 105
LEU G 108
ARG G 195
1.51A20.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		4 / 5
TYR H 143
PRO H 138
THR H 151
THR H 153
1.69A22.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		2ajf ACE2
(Homo
sapiens)		3 / 3
PRO A 583
LEU A 585
THR A 449
0.95A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		2ajf ACE2
(Homo
sapiens)		5 / 12
ALA B  65
SER B  43
ASN B  49
ASN B  61
GLY B  66
1.69A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2ajf ACE2
(Homo
sapiens)		5 / 12
ALA B 396
ASN B 572
LEU B 568
ARG B 559
GLY B 561
1.50A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		2ajf ACE2
(Homo
sapiens)		4 / 5
TYR B 587
PRO B 583
LEU B 520
THR B 445
1.55A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		2ajf ACE2
(Homo
sapiens)		5 / 12
ASN B 117
ASN B 121
ASN B  63
GLY B  66
ASP B  67
1.59A18.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.51A22.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO B 241
LEU B 242
THR B 292
0.97A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 147
SER A 144
HIS A 164
1.10A22.31
None
PJE  C   5 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER C 924
ASN E1169
THR B 922
GLY C 928
ASP C 932
1.40A13.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		2c3s 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.96A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 5
TYR A  43
PRO A  89
LEU A  15
THR B  23
1.76A14.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 5
TYR F  43
PRO F  89
THR E  73
SER E  56
1.78A15.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 5
TYR G  43
PRO G  89
LEU G  15
THR H  23
1.70A13.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 5
TYR A  43
PRO A  89
THR B  73
SER B  56
1.71A16.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 5
TYR C  43
PRO C  89
LEU C  15
THR D  23
1.66A13.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 5
TYR B  43
PRO B  89
LEU B  15
THR A  23
1.69A14.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 173
GLY B   2
GLY A 174
THR A 135
PHE A 112
1.38A22.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		2dd8 IGG HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 5
PRO H  52
LEU H  54
THR S 485
ARG S 426
1.39A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		2dd8 IGG HEAVY CHAIN
(Homo
sapiens)		3 / 3
PRO H  14
LEU H  82
THR H 108
0.77A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
ASN C 100
ASN B 100
ASN C  41
GLY C  52
ALA C  51
1.64A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
ALA C  51
ASN B 100
ASN B 102
ASN C  41
ALA C  39
1.64A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
TYR A  84
PRO A  60
LEU A  65
THR A  15
1.67A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2fyg REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
SER A  11
SER A  15
HIS A  80
1.23A15.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
TYR S  30
LEU S 112
THR S  39
ARG S  78
1.77A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ALA E  54
GLY E  50
ASN E  62
GLY E 121
THR E  56
1.51A18.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ALA B  33
SER B  52
ASN B  74
SER B  56
ARG A 426
1.56A22.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 12
ALA D  88
GLY D  10
THR D  91
PHE D  68
ARG D  67
1.52A23.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
CYH C 366
PRO C 399
THR C 372
SER C 370
1.68A19.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
SER D 163
ASN C 479
GLY D 200
SER D 199
GLY D 198
1.54A23.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 173
GLY A 138
GLY A 174
THR A 135
PHE A 112
1.30A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2jzd REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
SER A 634
SER A 530
HIS A 539
1.12A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		2jzf REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
PRO A 602
LEU A 603
THR A 594
0.99A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		4 / 5
TYR A  70
PRO A  11
THR A 102
ARG A 106
1.41A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		2kqv NSP3
(SARSr-CoV)		4 / 5
CYH A 101
TYR A  61
PRO A  66
THR A  83
1.64A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2og3 NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		5 / 12
ALA A 139
GLY A 125
ASN A 141
LEU A 114
GLY A 138
1.53A19.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		2og3 NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		4 / 5
TYR A  88
PRO A 169
THR A 136
ARG A  69
1.72A19.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
ALA A 116
SER A 123
LEU A 141
ARG B 298
GLY A 124
1.53A22.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
SER B 147
ASN B 119
SER B 144
GLY B 146
GLY B  29
1.64A21.36
None
None
WR1  B 602 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		3 / 3
SER B 147
SER B 144
HIS B 164
1.14A22.83
None
WR1  B 602 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
SER A   1
ASN A 214
THR B 135
GLY B 170
ASP A 216
1.54A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 12
ALA A 173
GLY A 138
GLY A 174
THR A 135
PHE A 112
1.41A22.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
ALA B 173
GLY A   2
GLY B 174
THR B 135
PHE B 112
1.38A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		3 / 3
PRO B  52
LEU B  57
THR B  24
0.98A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		3 / 3
SER B 147
SER B 144
HIS B 164
1.21A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		2qc2 3C-LIKE PROTEINASE
(-)		3 / 3
PRO B 241
LEU B 242
THR B 292
0.98A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
SER A 123
ASN A 142
ASN A  28
GLY A 124
ALA A 116
1.44A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
ALA B 116
SER B 123
LEU B 141
ARG A 298
GLY B 124
1.45A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
ASN A 142
SER A 123
ASN A  28
SER A 147
GLY A 146
1.62A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2qc2 3C-LIKE PROTEINASE
(-)		3 / 3
SER B 147
SER B 144
HIS B 164
1.21A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
SER A 123
ASN A 142
ASN A  28
GLY A 124
ALA A 116
1.45A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 173
GLY A 138
GLY A 174
THR A 135
PHE A 112
1.39A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 144
SER A 147
ASN A  28
ASN A 119
GLY A 143
1.78A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 144
SER A 147
ASN A  28
ASN A 119
GLY A 143
1.78A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
SER C 171
SER B 241
GLY B 243
SER B 287
GLY B 286
1.48A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 116
SER A 123
GLY B   2
LEU A 141
GLY A 124
1.27A22.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
SER A 123
ASN A 119
ASN A  28
GLY A 124
ALA A 116
1.79A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		2wct NSP3
(SARSr-CoV)		4 / 5
PRO C 602
LEU C 603
THR C 594
ARG C 628
1.61A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
SER A 105
ASN A  43
THR A 110
GLY A  73
ALA A  72
1.63A23.77
None
SAH  A1293 (-3.8A)
None
SAH  A1293 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
SER A 105
ASN A  43
THR A 110
GLY A  73
ALA A  72
1.62A23.77
None
SAH  A1293 (-3.8A)
None
SAH  A1293 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
SER A 105
ASN A  43
THR A 110
GLY A  73
ALA A  72
1.49A23.77
None
SAH  A1300 (-3.3A)
None
SAH  A1300 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
SER A 105
ASN A  43
THR A 110
GLY A  73
ALA A  72
1.50A23.77
None
SAH  A1300 (-3.3A)
None
SAH  A1300 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA B 173
GLY A   2
GLY B 174
THR B 135
PHE B 112
1.46A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.99A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 147
SER A 144
HIS A 164
1.14A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		3bgf F26G19 FAB
(Mus
musculus)		3 / 3
PRO B  14
LEU B  82
THR B   9
0.69A20.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
ALA L 130
GLY H 146
LEU H 143
GLY L 129
THR L 180
1.53A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3bgf F26G19 FAB
(Mus
musculus)		3 / 3
SER C 171
SER C 168
HIS B 166
1.32A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3bgf F26G19 FAB
(Mus
musculus)		3 / 3
SER B 163
SER B 162
HIS B 166
1.26A22.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
SER H 180
ASN L 137
SER L 176
THR L 178
GLY H 141
1.47A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
PRO B 583
LEU B 585
THR B 449
0.99A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA B 396
ASN B 572
LEU B 568
ARG B 559
GLY B 561
1.43A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA A  65
SER A  43
ASN A  49
ASN A  61
GLY A  66
1.65A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
TYR B 587
PRO B 583
LEU B 520
THR B 445
1.64A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		3d0i ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
TYR F 436
GLY F 434
ASN F 435
TYR B  41
ARG F 479
1.65A21.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 147
SER A 144
HIS A 164
1.01A22.83
None
959  A 350 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 123
ASN A 142
ASN A  28
GLY A 124
ALA A 116
1.58A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.95A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO B 241
LEU B 242
THR B 292
0.96A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 147
SER A 144
HIS A 164
1.14A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA B 116
SER B 123
LEU B 141
ARG A 298
GLY B 124
1.31A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		3e9s NSP3
(SARSr-CoV)		4 / 5
TYR A  28
PRO A  34
LEU A  59
THR A  55
1.78A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.61A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 123
ASN B 142
ASN B  28
GLY B 124
ALA B 116
1.59A22.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.61A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 147
SER A 144
HIS A 164
1.16A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.96A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.62A21.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.63A21.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
TYR A 209
LEU C 271
THR C 224
ARG C 222
1.28A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ASN D 274
ASN B 274
GLU B 270
THR D 225
ALA D 267
1.63A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ASN D 274
ASN B 274
GLU B 270
THR D 225
ALA D 267
1.60A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
PRO B 241
LEU B 242
THR B 292
0.97A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 173
GLY A 138
GLY A 174
THR A 135
PHE A 112
1.42A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN B 119
SER B 147
ASN B  28
GLY B 143
ALA B 140
1.66A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO A  52
LEU A  57
THR A  24
0.98A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 173
GLY A 138
GLY A 174
THR A 135
PHE A 112
1.31A22.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 147
ASN B 119
SER B 144
GLY B 146
GLY B  29
1.62A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 147
ASN B 119
SER B 144
GLY B 146
GLY B  29
1.62A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 116
SER A 123
ASN A 119
ASN A  28
ALA A 140
1.69A22.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO B  52
LEU B  57
THR B  24
0.96A22.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 116
SER A 123
ASN A 119
ASN A  28
ALA A 140
1.65A22.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 144
ASN B 119
ASN B  28
GLY B 143
GLY B 146
1.61A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 173
GLY B   2
GLY A 174
THR A 135
PHE A 112
1.48A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 123
ASN B 119
ASN B  28
GLY B 124
ALA B 116
1.79A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 144
ASN B 119
ASN B  28
GLY B 143
GLY B 146
1.61A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B 147
SER B 144
HIS B 164
1.19A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.95A21.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		3i6k HLA, A-2
(Homo
sapiens)		4 / 5
TYR E  27
LEU E 168
THR E 178
ARG E 181
1.65A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER D 147
ASN D 119
SER D 144
GLY D 146
GLY D  29
1.55A20.87
None
None
PJE  E   5 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 147
SER A 144
HIS A 164
1.07A22.28
None
PJE  H   5 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER D 147
ASN D 119
SER D 144
GLY D 146
GLY D  29
1.55A20.87
None
None
PJE  E   5 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA B 116
SER B 123
LEU B 141
ARG A 298
GLY B 124
1.27A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B 147
SER B 144
HIS B 164
1.11A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 144
SER A 147
ASN A  28
ASN A 119
GLY A 143
1.80A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 173
GLY A 138
GLY A 174
THR A 135
PHE A 112
1.35A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 123
ASN B 142
ASN B  28
GLY B 124
ALA B 116
1.45A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 123
ASN B 142
ASN B  28
GLY B 124
ALA B 116
1.48A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER B 147
SER B 144
HIS B 164
1.17A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO B 241
LEU B 242
THR B 292
0.98A22.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
PHE A 219
GLY A 275
ASN A 277
TYR A 237
LEU A 287
1.73A17.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA B 116
SER B 123
LEU B 141
ARG A 298
GLY B 124
1.30A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		5 / 12
ALA A  79
SER A  74
ASN A  43
GLY A  77
ARG B  78
1.73A21.47
None
SAM  A 302 ( 4.4A)
SAM  A 302 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		3sci ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU B  37
THR B 324
GLY F 488
GLY F 391
ASP F 393
1.49A18.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3sci ACE2
(Homo
sapiens)		5 / 12
ALA B 396
ASN B 572
LEU B 568
ARG B 559
GLY B 561
1.47A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		3sci ACE2
(Homo
sapiens)		5 / 12
ASN B 117
ASN B 121
ASN B  63
GLY B  66
ASP B  67
1.44A18.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		3scj ACE2
(Homo
sapiens)		3 / 3
PRO A 583
LEU A 585
THR A 449
0.94A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA B 396
ASN B 572
LEU B 568
ARG B 559
GLY B 561
1.42A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
TYR B 587
PRO B 583
LEU B 520
THR B 445
1.61A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		3 / 3
PRO A 583
LEU A 585
THR A 449
1.00A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA A  65
SER A  43
ASN A  49
ASN A  61
GLY A  66
1.63A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA A  65
SER A  43
ASN A  49
ASN A  61
GLY A  66
1.67A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 123
ASN A 119
ASN A  28
GLY A 124
ALA A 116
1.75A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO A  52
LEU A  57
THR A  24
0.96A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 123
ASN A 119
ASN A  28
GLY A 124
ALA A 116
1.76A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		3vb6 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 116
SER A 123
LEU A 141
ARG B 298
GLY A 124
1.19A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 147
SER A 144
HIS A 164
1.14A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 266
ASN A 274
ASN A 221
THR A 201
ALA A 267
1.73A21.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 147
ASN B 119
SER B 144
GLY B 146
GLY B  29
1.65A21.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 5
TYR A  84
PRO A  60
LEU A  65
THR A  15
1.71A20.81
None
None
GOL  A 405 (-4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
SER A 147
SER A 144
HIS A 164
1.17A22.86
None
23H  A 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.87
None
None
23H  A 401 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.87
None
None
23H  A 401 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		4mm3 UBIQUITIN
(Homo
sapiens)		3 / 3
PRO A  19
LEU A  56
THR A  14
0.70A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		3 / 3
SER A 318
SER A 319
HIS A 239
1.12A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.61A20.87
None
None
3A7  A 401 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.61A20.87
None
None
3A7  A 401 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.65A20.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
PRO B 241
LEU B 242
THR B 292
0.99A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 123
ASN B 119
ASN B  28
GLY B 124
ALA B 116
1.78A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.53A23.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 123
ASN B 119
ASN B  28
GLY B 124
ALA B 116
1.78A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		5c8s NSP10
(SARSr-CoV)		5 / 12
ALA A  54
GLY A  50
ASN A  62
GLY A 121
THR A  56
1.52A16.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 5
CYH B 387
PRO B 393
THR B 403
THR B 428
1.69A16.44
SAH  B 605 ( 3.8A)
None
None
G3A  B 606 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		5c8s GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		4 / 5
CYH C  74
PRO C  23
THR C   5
THR D  25
1.42A21.09
 ZN  C 201 (-2.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 5
CYH B 387
PRO B 393
THR B 403
THR B 428
1.77A16.41
SAM  B 605 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		5c8t GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 12
SER C  11
ASN D  63
THR D   5
GLY D  59
ASP D 243
1.45A21.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		6 / 12
ALA B 274
SER B 112
GLY B 413
ARG B  84
GLY B  88
THR B 277
1.73A21.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ALA D 504
ASN D 306
ASN D 422
THR D 428
GLY D 505
1.61A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
TYR A  73
PRO A  60
LEU A  65
THR A  15
1.68A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		5e6j POLYUBIQUITIN-B
(synthetic
construct)		3 / 3
PRO C  19
LEU C  56
THR C  14
0.67A16.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		5e6j UBIQUITIN
(synthetic
construct)		3 / 3
PRO E  19
LEU E  56
THR E  14
0.69A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		5f22 NSP8
(SARSr-CoV)		4 / 5
TYR B 143
PRO B 138
THR B 151
THR B 153
1.78A18.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ALA D 504
ASN D 306
ASN D 422
THR D 428
GLY D 505
1.52A18.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
SER M  11
ASN A  63
THR A   5
GLY A  59
ASP A 243
1.39A18.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ALA B 504
ASN B 306
ASN B 422
THR B 428
GLY B 505
1.60A18.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 5
CYH A 387
PRO A 393
THR A 403
THR A 428
1.71A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 5
CYH M  74
PRO M  23
THR M   5
THR A  25
1.44A18.68
 ZN  M 201 (-2.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ALA O  54
GLY O  50
ASN O  62
GLY O 121
THR O  56
1.41A16.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		5r7z 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.61A20.63
None
None
CL  A1006 ( 4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		5r80 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.61A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		5r81 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.96A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		5r82 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
SER A 147
SER A 144
HIS A 164
1.15A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.77A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
SER A 147
SER A 144
HIS A 164
1.16A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.99A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.38A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.63A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.21A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.63A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		5tl6 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens;
SARSr-CoV)		4 / 5
TYR D 208
PRO C 130
LEU C 131
ARG C  87
1.34A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		5tl6 UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens)		4 / 5
PRO C 130
LEU C 131
THR C 147
ARG C  87
1.46A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
TYR B  28
PRO B  34
THR B  55
SER B  86
1.54A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASN B 424
THR B 485
GLY B 488
GLY B 490
ASP B 392
1.58A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
SER A 845
ASN A 848
ASN A1104
THR A 798
ALA A1099
1.57A12.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 5
CYH B 348
TYR B 383
THR B 509
SER B 346
1.26A12.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		3 / 3
SER A  35
SER A  36
HIS A  33
1.25A13.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
SER C 717
ASN C 746
ASN B 304
THR C 841
GLY B 579
1.75A12.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
SER A 845
ASN A 848
ASN A1104
THR A 798
ALA A1099
1.58A12.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		5x5c S PROTEIN
(MERS-CoV)		4 / 5
TYR A 905
PRO C 739
LEU C 738
ARG A 887
1.76A12.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
SER B 350
SER C 829
GLU B 352
GLY B 340
ASP B 338
1.59A13.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
GLY B1154
SER B1151
PHE B1172
TYR B 777
LEU B 780
1.44A8.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
SER B 350
SER C 829
GLU B 352
GLY B 340
ASP B 338
1.61A13.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA B 875
SER C1052
GLU C1054
GLY B 873
ALA B 874
1.65A12.99
ALA  B 875 ( 0.0A)
SER  C1052 ( 0.0A)
GLU  C1054 ( 0.6A)
GLY  B 873 ( 0.0A)
ALA  B 874 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA A 875
SER B1052
GLU B1054
GLY A 873
ALA A 874
1.60A12.99
ALA  A 875 ( 0.0A)
SER  B1052 ( 0.0A)
GLU  B1054 ( 0.6A)
GLY  A 873 ( 0.0A)
ALA  A 874 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA C 251
LEU C 235
THR C  67
GLY C  68
THR C  71
1.47A14.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASN C 189
GLU A 452
ASN C 227
THR C 160
GLY C 104
1.55A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
TYR A 383
PRO A 413
LEU A 412
ARG A 453
1.66A12.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
SER B  35
SER B  36
HIS B  33
1.19A14.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE A1092
ASN A 901
SER A1052
TYR A1049
ARG A1055
1.76A9.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6ack ACE2
(Homo
sapiens)		4 / 5
TYR D 587
PRO D 583
LEU D 520
THR D 445
1.46A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER A 680
SER A 645
GLU A 647
GLY A 682
ALA A 683
1.48A12.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER A 680
SER A 645
GLU A 647
GLY A 682
ALA A 683
1.46A12.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ALA A 732
SER A 728
GLU A 730
ASN A 733
THR C 535
1.71A12.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 5
TYR B 383
PRO B 413
LEU B 412
ARG B 453
1.56A12.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ALA C 237
GLY C 100
ASN C  78
LEU C 235
THR C  20
1.53A14.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 5
TYR B1070
PRO B1061
THR B1099
THR B1098
1.61A12.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER B 680
SER B 645
GLU B 647
GLY B 682
ALA B 683
1.71A12.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER C 728
GLU C 730
ASN C 960
GLY C 726
ASP C 961
1.53A12.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER C 728
GLU C 730
ASN C 960
GLY C 726
ASP C 961
1.52A12.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER C 728
GLU C 730
ASN C 733
THR B 535
ARG B 306
1.69A12.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6cs2 ACE2
(Homo
sapiens)		5 / 12
ALA D  65
SER D  43
ASN D  49
ASN D  61
GLY D  66
1.62A18.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6cs2 ACE2
(Homo
sapiens)		5 / 12
ALA D  65
SER D  43
ASN D  49
ASN D  61
GLY D  66
1.63A18.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
SER A  35
SER A  36
HIS A  33
1.21A14.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
TYR A 159
GLY A 100
ASN A 114
MET A  98
ARG A  62
1.76A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		6jyt HELICASE
(SARSr-CoV)		4 / 5
CYH A 426
TYR A 457
PRO A 434
SER A 377
1.57A19.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6jyt HELICASE
(SARSr-CoV)		3 / 3
PRO A 175
LEU A 176
THR A 153
0.90A18.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.63
None
None
ELL  D   3 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.16A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.78A20.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.58A20.21
None
DMS  A 402 ( 4.4A)
None
None
DMS  A 402 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.63
None
None
ELL  D   3 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.04A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.40A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN B 437
SER B 443
ASN B 439
GLY B 496
ASP B 405
1.37A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN B 437
SER B 443
ASN B 439
GLY B 496
ASP B 405
1.37A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6m0j ACE2
(Homo
sapiens)		5 / 12
ALA A  65
SER A  43
ASN A  49
ASN A  61
GLY A  66
1.70A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6m0j ACE2
(Homo
sapiens)		5 / 12
ALA A  65
SER A  43
ASN A  49
ASN A  61
GLY A  66
1.67A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.19A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 5
CYH A 300
PRO A 293
THR A 304
SER A 301
1.74A20.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.60A21.88
None
DMS  A 404 ( 4.8A)
None
None
DMS  A 404 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.01A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.76A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.41A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.63A20.57
None
None
ELL  D   3 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.57
None
None
ELL  D   3 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6m17 ACE2
(Homo
sapiens)		4 / 5
TYR B 587
PRO B 583
LEU B 520
THR B 445
1.66A16.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6m17 ACE2
RECEPTOR BINDING
DOMAIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ASN F 439
ASN F 501
GLY F 504
GLY F 502
ASP D 355
1.52A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m17 ACE2
RECEPTOR BINDING
DOMAIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ASN F 439
ASN F 501
GLY F 504
GLY F 502
ASP D 355
1.55A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m18 ACE2
SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
SER D 626
SER D 721
GLU C 352
GLY D 629
ASP D 630
1.62A15.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6m18 ACE2
SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
SER D 626
SER D 721
GLU C 352
GLY D 629
ASP D 630
1.58A15.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		6m1d ACE2
(Homo
sapiens)		5 / 12
ARG D 514
GLY D 399
TYR D 521
ARG D 204
LEU D 222
1.80A10.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ALA C 273
SER C 278
ASN C  54
GLY C 272
ALA C 271
1.75A18.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6m1d ACE2
(Homo
sapiens)		5 / 12
ALA D 342
ASN D  58
GLU D  56
ASN D  53
THR D 347
1.48A16.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m1d ACE2
(Homo
sapiens)		3 / 3
PRO D 415
LEU D 418
THR D 365
0.96A16.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
SER A 323
LEU A 242
GLY A 250
THR A 248
PHE A 255
1.45A21.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ALA C 273
SER C 278
ASN C  54
GLY C 272
ALA C 271
1.74A18.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6m1d ACE2
(Homo
sapiens)		5 / 12
ALA D 342
ASN D  58
GLU D  56
ASN D  53
THR D 347
1.49A16.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO B 241
LEU B 242
THR B 292
1.16A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER D 147
ASN D 119
SER D 144
GLY D 146
GLY D  29
1.65A20.63
None
None
3WL  D 401 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO D  52
LEU D  57
THR D  24
1.00A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.68A20.63
None
None
3WL  A 401 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C 173
GLY A   2
GLY C 174
THR C 135
PHE C 112
1.43A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.20A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO D 252
LEU D 253
THR D 201
1.42A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO C  52
LEU C  57
THR C  24
1.16A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D 116
SER D 123
GLY B   2
LEU D 141
GLY D 124
1.61A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D   7
SER D 113
GLY D  11
LEU D 115
ARG D 298
1.73A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.67A20.63
None
None
3WL  A 401 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO C 241
LEU C 242
THR C 292
1.04A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER B 147
ASN B 119
SER B 144
GLY B 146
GLY B  29
1.67A20.63
None
None
3WL  B 401 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B 173
GLY D   2
GLY B 174
THR B 135
PHE B 112
1.44A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.72A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER C 147
ASN C 119
SER C 144
GLY C 146
GLY C  29
1.65A20.63
None
None
3WL  C 401 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER B 147
ASN B 119
SER B 144
GLY B 146
GLY B  29
1.67A20.63
None
None
3WL  B 401 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.43A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C   7
SER C 113
GLY C  11
LEU C 115
ARG C 298
1.74A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.05A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C 116
SER C 123
GLY A   2
LEU C 141
GLY C 124
1.59A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C 173
GLY C 109
THR C 175
GLY C 174
THR C 135
1.79A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B 173
GLY B 109
THR B 175
GLY B 174
THR B 135
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 116
SER A 123
GLY C   2
LEU A 141
GLY A 124
1.50A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER D 147
ASN D 119
SER D 144
GLY D 146
GLY D  29
1.65A20.63
None
None
3WL  D 401 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B 116
SER B 123
GLY D   2
LEU B 141
GLY B 124
1.47A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO B  52
LEU B  57
THR B  24
1.22A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO D 241
LEU D 242
THR D 292
1.02A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B   7
SER B 113
GLY B  11
LEU B 115
ARG B 298
1.76A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D 173
GLY D 109
THR D 175
GLY D 174
THR D 135
1.79A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER C 147
ASN C 119
SER C 144
GLY C 146
GLY C  29
1.65A20.63
None
None
3WL  C 401 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY C   2
GLY A 174
THR A 135
PHE A 112
1.42A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.40A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.65A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.98A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.76A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.10A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.66A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 558
SER A 682
GLY A 678
THR A 556
THR A 540
1.69A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASN A 507
ASN A 543
THR A 565
GLY A 683
ALA A 558
1.72A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6m71 NSP12
(SARS-CoV-2)		4 / 5
TYR A 129
PRO A 243
LEU A 247
THR A 141
1.80A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
TYR A 456
GLY A 679
ASN A 459
MET A 626
SER A 681
1.79A10.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.52A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASN A 507
ASN A 543
THR A 565
GLY A 683
ALA A 558
1.70A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.52A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m71 NSP12
(SARS-CoV-2)		5 / 12
SER A 681
ASN A 691
SER A 682
THR A 556
GLY A 679
1.70A14.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA A 938
ASN A 838
ASN A 942
ALA A 940
ARG A 996
1.67A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER H 193
ASN L 142
SER L 181
THR L 183
GLY H 153
1.43A22.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		3 / 3
PRO H  14
LEU H  86
THR H 122
0.97A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		6nus NSP12
(SARSr-CoV)		4 / 5
CYH A 659
TYR A 456
PRO A 627
THR A 540
1.67A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6nus NSP12
(SARSr-CoV)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.46A15.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		6nus NSP12
(SARSr-CoV)		5 / 12
TYR A 456
GLY A 679
ASN A 459
MET A 626
SER A 681
1.70A10.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6nus NSP12
(SARSr-CoV)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.46A15.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
PRO A 225
LEU A 226
THR A 208
ARG A  34
1.32A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B 893
SER B 884
GLY A1046
THR B 881
GLY B 880
1.53A13.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
PRO A 225
LEU A 226
THR A 208
0.85A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B 890
ASN A1108
THR A 719
GLY B 891
ALA B 892
1.65A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B 890
ASN A1108
THR A 719
GLY B 891
ALA B 892
1.64A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		6vw1 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO E 507
GLY E 496
ASN E 501
TYR E 453
ARG E 509
1.71A22.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6vw1 ACE2
(Homo
sapiens)		5 / 12
ALA A  65
SER A  43
ASN A  49
ASN A  61
GLY A  66
1.70A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6vw1 ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLU B  37
THR B 324
GLY F 502
GLY F 404
ASP F 406
1.62A18.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vxs NSP3
(SARS-CoV-2)		3 / 3
PRO B 136
LEU B 126
THR B 146
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vxs NSP3
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 146
0.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vxs NSP3
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 149
0.88A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vxs NSP3
(SARS-CoV-2)		3 / 3
PRO A 136
LEU A 126
THR A 146
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vxs NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 149
0.92A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vxs NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 146
0.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA C1056
SER C1055
GLU C 819
THR C 778
GLY C1059
1.75A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER C 746
GLU C 748
THR C 739
GLY C 744
ASP C 979
1.57A12.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA C1056
SER C1055
GLU C 819
THR C 778
GLY C1059
1.71A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
PRO A 225
LEU A 226
THR A 208
0.78A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
PRO C 225
LEU C 226
THR C 208
0.79A13.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		4 / 5
TYR B 112
PRO B 142
THR A  57
ARG A 107
1.72A17.92
None
None
ZN  A 202 ( 3.8A)
MES  A 203 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		3 / 3
PRO H 123
LEU H 124
THR L 180
1.25A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 5
TYR H 176
PRO H 119
THR H 108
THR H   9
1.73A22.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		3 / 3
SER L 162
SER L 176
HIS H 164
1.52A18.90
GOL  L 301 (-3.2A)
GOL  L 301 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		3 / 3
PRO L  59
LEU L  47
THR L  20
1.45A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6w41 CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER L  27
SER L  27
HIS C 519
1.41A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		3 / 3
PRO H  14
LEU H  82
THR H   9
0.78A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		3 / 3
PRO H  14
LEU H  82
THR H 108
0.79A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		3 / 3
PRO H 167
LEU H 178
THR L 180
1.75A20.43
None
GOL  L 301 (-4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
ASN C 437
SER C 443
ASN C 439
GLY C 496
ASP C 405
1.36A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
ASN C 437
SER C 443
ASN C 439
GLY C 496
ASP C 405
1.34A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w4b NSP9
(SARS-CoV-2)		5 / 12
ALA B  44
ASN B  34
SER B 106
THR B 110
ALA B  31
1.65A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6w4b NSP9
(SARS-CoV-2)		5 / 12
ALA B  44
ASN B  34
SER B 106
THR B 110
ALA B  31
1.64A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w4h NSP16
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.69A23.60
None
SAM  A7102 (-3.6A)
None
SAM  A7102 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA A6877
SER A6872
ASN A6841
GLY A6875
ARG B4331
1.72A
None
SAM  A7104 (-4.4A)
SAM  A7104 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
PRO A7034
LEU A6825
THR A6993
1.73A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.68A
None
SAM  A7104 (-3.3A)
None
SAM  A7104 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.03A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.03A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.66A20.63
None
None
X77  A 401 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.66A20.63
None
None
X77  A 401 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO A 136
LEU A 126
THR A 146
1.40A
None
AMP  A 201 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 126
THR A  13
1.52A19.72
None
AMP  A 201 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 126
THR B  13
1.55A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 146
0.95A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 126
THR B 146
1.72A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 123
THR A  57
1.67A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO B 136
LEU B 126
THR B 146
1.45A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 126
THR A 146
1.67A19.72
None
AMP  A 201 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 123
THR B  57
1.67A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6903
ASN C6841
THR C6908
GLY C6871
ALA C6870
1.69A21.90
None
SAM  C7105 ( 3.7A)
None
SAM  C7105 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6903
ASN C6841
THR C6908
GLY C6871
ALA C6870
1.71A21.90
None
SAM  C7105 ( 3.7A)
None
SAM  C7105 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
PRO A7034
LEU A6825
THR A6993
1.77A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA C6870
GLY D4347
LEU C6893
GLY C6871
THR C6908
1.79A18.46
None
None
None
SAM  C7105 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA A6877
SER A6872
ASN A6841
GLY A6875
ARG B4331
1.79A21.90
None
SAM  A7102 ( 4.6A)
SAM  A7102 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.67A21.90
None
SAM  A7102 ( 3.4A)
None
SAM  A7102 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
PRO C7034
LEU C6825
THR C6993
1.74A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
PRO A7049
LEU A7050
THR A6880
1.48A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
PRO C7049
LEU C7050
THR C6880
1.48A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.69A21.90
None
SAM  A7102 ( 3.4A)
None
SAM  A7102 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA C6877
SER C6872
ASN C6841
GLY C6875
ARG D4331
1.77A21.90
None
SAM  C7105 ( 4.4A)
SAM  C7105 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
PRO C  77
LEU C  80
THR C  63
1.08A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
SER A 105
ASN A  33
THR A 109
GLY A 104
GLY A 100
1.76A19.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wcf NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 146
0.96A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wcf NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 149
0.98A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wen NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 149
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wen NSP3
(SARS-CoV-2)		3 / 3
PRO A 136
LEU A 126
THR A 146
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wen NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 146
0.92A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wiq NSP8
(SARS-CoV-2)		5 / 12
ALA B 150
SER B 151
ASN B 100
LEU B 103
ARG B 190
1.60A16.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA F 336
GLY E 275
THR F 334
GLY F 335
THR E 282
1.74A16.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA C 336
GLY D 275
THR C 334
GLY C 335
THR D 282
1.78A16.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA C6870
GLY D4347
LEU C6893
GLY C6871
THR C6908
1.80A22.94
None
None
None
SAH  C7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA A6877
SER A6872
ASN A6841
GLY A6875
ARG B4331
1.76A
None
SAH  A7102 ( 4.6A)
SAH  A7102 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.70A23.60
None
SAH  A7102 (-3.6A)
None
SAH  A7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER C6903
ASN C6841
THR C6908
GLY C6871
ALA C6870
1.72A23.60
None
SAH  C7102 (-3.7A)
None
SAH  C7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.69A
None
SAH  A7102 (-3.6A)
None
SAH  A7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA C6877
SER C6872
ASN C6841
GLY C6875
ARG D4331
1.75A
None
SAH  C7102 (-4.7A)
SAH  C7102 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER C6903
ASN C6841
THR C6908
GLY C6871
ALA C6870
1.70A
None
SAH  C7102 (-3.7A)
None
SAH  C7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
TYR D 112
PRO D 142
THR C  57
ARG C 107
1.75A17.56
None
None
ZN  D 202 ( 4.7A)
MES  D 201 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
TYR B 112
PRO B 142
THR A  57
ARG A 107
1.58A17.56
None
None
MES  B 201 (-4.7A)
MES  B 201 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.69A
None
FMT  A7104 ( 3.1A)
None
SFG  A7103 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6903
ASN C6841
THR C6908
GLY C6871
ALA C6870
1.72A23.60
None
FMT  C7112 ( 3.3A)
None
SFG  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.70A23.60
None
FMT  A7104 ( 3.1A)
None
SFG  A7103 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA C6870
GLY D4347
LEU C6893
GLY C6871
THR C6908
1.79A22.94
None
None
None
SFG  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6903
ASN C6841
THR C6908
GLY C6871
ALA C6870
1.70A
None
FMT  C7112 ( 3.3A)
None
SFG  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA C6877
SER C6872
ASN C6841
GLY C6875
ARG D4331
1.77A
None
SFG  C7103 ( 4.5A)
FMT  C7112 ( 3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA A6877
SER A6872
ASN A6841
GLY A6875
ARG B4331
1.79A
None
SFG  A7103 ( 4.5A)
FMT  A7104 ( 3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA A6870
GLY B4347
LEU A6893
GLY A6871
THR A6908
1.80A22.94
None
None
None
SFG  A7103 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
SER A 147
SER A 144
HIS A 164
1.16A21.84
None
U5G  A 401 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.77A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.65A20.63
None
None
U5G  A 401 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.66A20.63
None
None
U5G  A 401 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.70A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.01A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO C 136
LEU C 126
THR C 146
1.43A
None
APR  C 201 (-4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO D 125
LEU D 153
THR D 149
1.00A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO D 125
LEU D 153
THR D 146
0.90A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 146
0.96A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO C 125
LEU C 153
THR C 146
0.89A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.69A23.60
None
SO4  A7109 ( 3.2A)
None
SAH  A7101 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA A6870
GLY B4347
LEU A6893
GLY A6871
THR A6908
1.80A22.94
None
None
None
SAH  A7101 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA A6877
SER A6872
ASN A6841
GLY A6875
ARG B4331
1.75A
None
SO4  A7109 (-4.5A)
SO4  A7109 ( 3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.67A
None
SO4  A7109 ( 3.2A)
None
SAH  A7101 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wqd NSP8
(SARS-CoV-2)		5 / 12
ALA D 150
SER D 151
ASN D 100
LEU D 103
ARG D 190
1.42A16.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wqd NSP8
(SARS-CoV-2)		5 / 12
ALA B 150
SER B 151
ASN B 100
LEU B 103
ARG B 190
1.51A16.38
EDO  B 302 (-3.7A)
None
None
None
EDO  B 302 (-2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 116
SER A 123
GLY B   2
LEU A 141
GLY A 124
1.48A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.25A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A19.53
None
None
DMS  A 405 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.00A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
SER A 147
SER A 144
HIS A 164
1.16A17.36
None
DMS  A 405 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.77A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.37A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A19.53
None
None
DMS  A 405 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ALA D 150
SER D 151
ASN D 100
LEU D 103
ARG D 190
1.68A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ALA B 150
SER B 151
ASN B 100
LEU B 103
ARG B 190
1.53A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		3 / 3
PRO A 128
LEU A  24
THR A  14
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 5
TYR A 132
PRO A 128
LEU A 121
THR A  14
1.80A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
PRO A 337
LEU A 335
THR A 531
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yla HEAVY CHAIN
(Homo
sapiens)		3 / 3
PRO B  14
LEU B  86
THR B   9
0.75A
None
None
MLI  B 304 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER C  33
SER C  32
HIS A 519
1.57A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 5
TYR B 180
PRO B 123
THR B  91
THR B 116
1.69A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yla HEAVY CHAIN
(Homo
sapiens)		3 / 3
PRO B  14
LEU B  86
THR B 114
0.76A
None
None
MLI  B 304 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yla HEAVY CHAIN
(Homo
sapiens)		3 / 3
PRO H  14
LEU H  86
THR H   9
0.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yla LIGHT CHAIN
(Homo
sapiens)		3 / 3
PRO C  65
LEU C  53
THR C  20
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER L  33
SER L  32
HIS E 519
1.63A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yla LIGHT CHAIN
(Homo
sapiens)		3 / 3
PRO L  65
LEU L  53
THR L  20
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
SER B 100
GLY A 431
LEU A 387
GLY B  99
THR B 104
1.75A19.13
None
None
DMS  A 905 ( 4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 5
TYR H 180
PRO H 123
THR H  91
THR H 116
1.74A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
PRO H 127
LEU H 128
THR L 186
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 530
ASN A 334
ASN A 532
LYS E 529
GLY A 526
1.52A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yla LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER L 208
SER L 209
HIS L 204
1.30A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yla LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER C 208
SER C 209
HIS C 204
1.29A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
SER B   7
ASN H 203
SER B  21
GLU B  10
THR B  78
1.56A22.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
SER B   7
ASN H 203
SER B  21
GLU B  10
THR B  78
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER C  28
ASN C  35
GLY C  74
SER C  73
GLY C  72
1.77A22.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 530
ASN A 334
ASN A 532
LYS E 529
GLY A 526
1.54A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
PRO B 127
LEU B 128
THR C 186
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER C  32
SER C  33
HIS A 519
1.04A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yla HEAVY CHAIN
(Homo
sapiens)		3 / 3
PRO H  14
LEU H  86
THR H 114
0.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER L 174
SER L 177
HIS H 168
1.65A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER L  32
SER L  33
HIS E 519
1.07A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN A 437
SER A 443
ASN A 439
GLY A 496
ASP A 405
1.34A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN E 437
SER E 443
ASN E 439
GLY E 496
ASP E 405
1.37A19.43
None
None
None
MLI  E 903 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN A 437
SER A 443
ASN A 439
GLY A 496
ASP A 405
1.34A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
SER H 157
ASN H 203
ASN H 201
GLY H 161
SER H 160
1.50A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
SER H 100
GLY E 431
LEU E 387
GLY H  99
THR H 104
1.59A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6ym0 LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER L  32
SER L  33
HIS E 519
1.17A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN E 437
SER E 443
ASN E 439
GLY E 496
ASP E 405
1.27A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 5
TYR H 180
PRO H 123
THR H  91
THR H 116
1.76A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ym0 HEAVY CHAIN
(Homo
sapiens)		3 / 3
PRO H  14
LEU H  86
THR H   9
0.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN E 437
SER E 443
ASN E 439
GLY E 496
ASP E 405
1.27A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER L 168
SER L 182
HIS H 168
1.63A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6ym0 LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER L 208
SER L 209
HIS L 204
1.32A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
SER H 157
ASN H 203
ASN H 201
GLY H 161
SER H 160
1.52A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6ym0 LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER L  33
SER L  32
HIS E 519
1.57A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
SER L 174
SER L 177
HIS H 168
1.67A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		3 / 3
PRO H 127
LEU H 128
THR L 186
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  32
ASN L  35
ASN L  37
SER L  28
GLY L  74
1.63A22.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ym0 HEAVY CHAIN
(Homo
sapiens)		3 / 3
PRO H  14
LEU H  86
THR H 114
0.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.65A21.65
None
None
P6N  A 502 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.65A21.65
None
None
P6N  A 502 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.95A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN A 437
SER A 443
ASN A 439
GLY A 496
ASP A 405
1.37A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yor IGG L CHAIN
(Homo
sapiens)		3 / 3
SER C 208
SER C 209
HIS C 204
1.30A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yor IGG L CHAIN
(Homo
sapiens)		3 / 3
PRO L  65
LEU L  53
THR L  20
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER L  33
SER L  32
HIS E 519
1.64A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
SER H 157
ASN H 203
ASN H 201
GLY H 161
SER H 160
1.50A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
PRO B 127
LEU B 128
THR C 186
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yor IGG H CHAIN
(Homo
sapiens)		3 / 3
PRO B  14
LEU B  86
THR B   9
0.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yor IGG L CHAIN
(Homo
sapiens)		3 / 3
PRO C  65
LEU C  53
THR C  20
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 5
TYR H 180
PRO H 123
THR H  91
THR H 116
1.73A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER C  32
SER C  33
HIS A 519
1.07A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yor IGG H CHAIN
(Homo
sapiens)		3 / 3
PRO H  14
LEU H  86
THR H   9
0.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yor IGG H CHAIN
(Homo
sapiens)		3 / 3
PRO B  14
LEU B  86
THR B 114
0.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN E 437
SER E 443
ASN E 439
GLY E 496
ASP E 405
1.36A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER L  32
SER L  33
HIS E 519
1.07A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yor IGG H CHAIN
(Homo
sapiens)		3 / 3
PRO H  14
LEU H  86
THR H 114
0.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
PRO H 127
LEU H 128
THR L 186
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
SER L 174
SER L 177
HIS H 168
1.64A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER C  33
SER C  32
HIS A 519
1.63A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yor IGG L CHAIN
(Homo
sapiens)		3 / 3
SER L 208
SER L 209
HIS L 204
1.30A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
SER B 157
ASN B 203
ASN B 201
GLY B 161
SER B 160
1.49A22.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		3 / 3
SER C 174
SER C 177
HIS B 168
1.64A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.74A21.84
None
PEG  A 405 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.65A21.65
None
None
DMS  A 403 ( 2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.95A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.66A21.65
None
None
DMS  A 403 ( 2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO D 125
LEU D 153
THR D 149
1.04A
None
None
EDO  D 203 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 146
0.91A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 149
1.01A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO C 125
LEU C 153
THR C 149
1.01A
None
None
EDO  C 206 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO D 136
LEU D 126
THR D 146
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO E 125
LEU E 153
THR E 146
0.91A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO E 125
LEU E 153
THR E 149
1.00A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 146
0.93A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 149
1.02A
None
None
EDO  A 203 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO C 125
LEU C 153
THR C 146
0.87A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 146
0.94A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO C 125
LEU C 153
THR C 146
0.90A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO C 136
LEU C 126
THR C 146
1.41A
None
APR  C 201 (-4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C  89
GLY C  51
ASN C  37
GLY C  85
PHE D 156
1.77A20.65
None
None
None
None
EDO  D 204 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 146
0.89A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO E 125
LEU E 153
THR E 146
0.92A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO D 136
LEU D 126
THR D 146
1.42A
None
APR  D 201 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 149
1.00A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 146
0.93A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 146
0.92A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 149
1.01A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO B 136
LEU B 126
THR B 146
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.76A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.63
None
None
PJE  C   5 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.63
None
None
PJE  C   5 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		3 / 3
PRO A  39
LEU A  87
THR A  24
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.02A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 558
SER A 561
ASN A 507
ASN A 543
THR A 538
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 558
SER A 561
ASN A 507
ASN A 543
THR A 538
1.77A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A 501
ASN A 507
ASN A 543
THR A 565
ALA A 558
1.61A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
SER A 384
LYS B  97
THR A 402
GLY A 385
ALA A 382
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 383
SER A 384
LYS B  97
GLY A 385
ALA A 382
1.67A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7btf NSP8
(SARS-CoV-2)		3 / 3
PRO D 178
LEU D 180
THR D 137
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 558
SER A 682
GLY A 678
THR A 556
THR A 540
1.68A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 383
SER A 384
LYS B  97
GLY A 385
ALA A 382
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7btf NSP8
(SARS-CoV-2)		5 / 12
ALA D 150
SER D 151
ASN D 100
LEU D 103
ARG D 190
1.79A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 383
SER A 384
LYS B  97
GLY A 385
ALA A 399
1.80A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 383
SER A 384
LYS B  97
GLY A 385
ALA A 399
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.54A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.63
None
None
DMS  A 402 ( 3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.77A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.61A21.84
None
DMS  A 406 ( 4.8A)
None
None
DMS  A 406 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.02A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		3 / 3
SER A 147
SER A 144
HIS A 164
1.18A21.84
None
DMS  A 402 ( 3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.63
None
None
DMS  A 402 ( 3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 400
SER A 672
SER A 397
ASN A 386
THR A 393
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 501
ASN A 507
ASN A 543
THR A 565
ALA A 558
1.61A15.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 501
ASN A 507
ASN A 543
THR A 565
GLY A 559
1.77A13.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 400
SER A 672
SER A 397
ASN A 386
THR A 393
1.55A15.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.58A15.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 501
ASN A 507
ASN A 543
THR A 565
ALA A 558
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.48A15.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
SER A 681
ASN A 691
SER A 682
THR A 556
GLY A 679
1.78A13.51
None
F86  P 102 (-4.2A)
U  T  10 (-2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 558
SER A 682
GLY A 678
THR A 556
THR A 540
1.79A18.12
None
U  T  10 (-2.9A)
None
None
None