Ligand ID: CFX


Drugbank ID:
DB01331
(Cefoxitin)


Indication:
For the treatment of serious infections caused by susceptible strains microorganisms.

Get human targets for CFX in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'CFX' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		5r7z 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.61A20.63
None
None
CL  A1006 ( 4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		5r80 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.61A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		5r81 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.96A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		5r82 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
SER A 147
SER A 144
HIS A 164
1.15A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.77A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
SER A 147
SER A 144
HIS A 164
1.16A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.99A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.38A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.63A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.21A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.63A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.63
None
None
ELL  D   3 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.16A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.78A20.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.58A20.21
None
DMS  A 402 ( 4.4A)
None
None
DMS  A 402 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.63
None
None
ELL  D   3 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.04A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.40A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN B 437
SER B 443
ASN B 439
GLY B 496
ASP B 405
1.37A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN B 437
SER B 443
ASN B 439
GLY B 496
ASP B 405
1.37A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.19A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 5
CYH A 300
PRO A 293
THR A 304
SER A 301
1.74A20.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.60A21.88
None
DMS  A 404 ( 4.8A)
None
None
DMS  A 404 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.01A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.76A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.41A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.63A20.57
None
None
ELL  D   3 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.57
None
None
ELL  D   3 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6m17 ACE2
RECEPTOR BINDING
DOMAIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ASN F 439
ASN F 501
GLY F 504
GLY F 502
ASP D 355
1.52A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m17 ACE2
RECEPTOR BINDING
DOMAIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ASN F 439
ASN F 501
GLY F 504
GLY F 502
ASP D 355
1.55A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO B 241
LEU B 242
THR B 292
1.16A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER D 147
ASN D 119
SER D 144
GLY D 146
GLY D  29
1.65A20.63
None
None
3WL  D 401 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO D  52
LEU D  57
THR D  24
1.00A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.68A20.63
None
None
3WL  A 401 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C 173
GLY A   2
GLY C 174
THR C 135
PHE C 112
1.43A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.20A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO D 252
LEU D 253
THR D 201
1.42A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO C  52
LEU C  57
THR C  24
1.16A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D 116
SER D 123
GLY B   2
LEU D 141
GLY D 124
1.61A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D   7
SER D 113
GLY D  11
LEU D 115
ARG D 298
1.73A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.67A20.63
None
None
3WL  A 401 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO C 241
LEU C 242
THR C 292
1.04A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER B 147
ASN B 119
SER B 144
GLY B 146
GLY B  29
1.67A20.63
None
None
3WL  B 401 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B 173
GLY D   2
GLY B 174
THR B 135
PHE B 112
1.44A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.72A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER C 147
ASN C 119
SER C 144
GLY C 146
GLY C  29
1.65A20.63
None
None
3WL  C 401 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER B 147
ASN B 119
SER B 144
GLY B 146
GLY B  29
1.67A20.63
None
None
3WL  B 401 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.43A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C   7
SER C 113
GLY C  11
LEU C 115
ARG C 298
1.74A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.05A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C 116
SER C 123
GLY A   2
LEU C 141
GLY C 124
1.59A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C 173
GLY C 109
THR C 175
GLY C 174
THR C 135
1.79A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B 173
GLY B 109
THR B 175
GLY B 174
THR B 135
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 116
SER A 123
GLY C   2
LEU A 141
GLY A 124
1.50A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER D 147
ASN D 119
SER D 144
GLY D 146
GLY D  29
1.65A20.63
None
None
3WL  D 401 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B 116
SER B 123
GLY D   2
LEU B 141
GLY B 124
1.47A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO B  52
LEU B  57
THR B  24
1.22A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO D 241
LEU D 242
THR D 292
1.02A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B   7
SER B 113
GLY B  11
LEU B 115
ARG B 298
1.76A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D 173
GLY D 109
THR D 175
GLY D 174
THR D 135
1.79A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER C 147
ASN C 119
SER C 144
GLY C 146
GLY C  29
1.65A20.63
None
None
3WL  C 401 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY C   2
GLY A 174
THR A 135
PHE A 112
1.42A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.40A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.65A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.98A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.76A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.10A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.66A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 558
SER A 682
GLY A 678
THR A 556
THR A 540
1.69A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASN A 507
ASN A 543
THR A 565
GLY A 683
ALA A 558
1.72A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6m71 NSP12
(SARS-CoV-2)		4 / 5
TYR A 129
PRO A 243
LEU A 247
THR A 141
1.80A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
TYR A 456
GLY A 679
ASN A 459
MET A 626
SER A 681
1.79A10.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.52A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASN A 507
ASN A 543
THR A 565
GLY A 683
ALA A 558
1.70A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.52A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6m71 NSP12
(SARS-CoV-2)		5 / 12
SER A 681
ASN A 691
SER A 682
THR A 556
GLY A 679
1.70A14.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
PRO A 225
LEU A 226
THR A 208
ARG A  34
1.32A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B 893
SER B 884
GLY A1046
THR B 881
GLY B 880
1.53A13.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
PRO A 225
LEU A 226
THR A 208
0.85A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B 890
ASN A1108
THR A 719
GLY B 891
ALA B 892
1.65A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B 890
ASN A1108
THR A 719
GLY B 891
ALA B 892
1.64A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vxs NSP3
(SARS-CoV-2)		3 / 3
PRO B 136
LEU B 126
THR B 146
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vxs NSP3
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 146
0.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vxs NSP3
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 149
0.88A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vxs NSP3
(SARS-CoV-2)		3 / 3
PRO A 136
LEU A 126
THR A 146
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vxs NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 149
0.92A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vxs NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 146
0.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA C1056
SER C1055
GLU C 819
THR C 778
GLY C1059
1.75A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER C 746
GLU C 748
THR C 739
GLY C 744
ASP C 979
1.57A12.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA C1056
SER C1055
GLU C 819
THR C 778
GLY C1059
1.71A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
PRO A 225
LEU A 226
THR A 208
0.78A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
PRO C 225
LEU C 226
THR C 208
0.79A13.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		4 / 5
TYR B 112
PRO B 142
THR A  57
ARG A 107
1.72A17.92
None
None
ZN  A 202 ( 3.8A)
MES  A 203 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6w41 CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER L  27
SER L  27
HIS C 519
1.41A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
ASN C 437
SER C 443
ASN C 439
GLY C 496
ASP C 405
1.36A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
ASN C 437
SER C 443
ASN C 439
GLY C 496
ASP C 405
1.34A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w4b NSP9
(SARS-CoV-2)		5 / 12
ALA B  44
ASN B  34
SER B 106
THR B 110
ALA B  31
1.65A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6w4b NSP9
(SARS-CoV-2)		5 / 12
ALA B  44
ASN B  34
SER B 106
THR B 110
ALA B  31
1.64A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w4h NSP16
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.69A23.60
None
SAM  A7102 (-3.6A)
None
SAM  A7102 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA A6877
SER A6872
ASN A6841
GLY A6875
ARG B4331
1.72A
None
SAM  A7104 (-4.4A)
SAM  A7104 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
PRO A7034
LEU A6825
THR A6993
1.73A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.68A
None
SAM  A7104 (-3.3A)
None
SAM  A7104 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.03A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.03A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.66A20.63
None
None
X77  A 401 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.66A20.63
None
None
X77  A 401 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO A 136
LEU A 126
THR A 146
1.40A
None
AMP  A 201 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 126
THR A  13
1.52A19.72
None
AMP  A 201 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 126
THR B  13
1.55A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 146
0.95A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 126
THR B 146
1.72A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 123
THR A  57
1.67A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO B 136
LEU B 126
THR B 146
1.45A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 126
THR A 146
1.67A19.72
None
AMP  A 201 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 123
THR B  57
1.67A19.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6903
ASN C6841
THR C6908
GLY C6871
ALA C6870
1.69A21.90
None
SAM  C7105 ( 3.7A)
None
SAM  C7105 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6903
ASN C6841
THR C6908
GLY C6871
ALA C6870
1.71A21.90
None
SAM  C7105 ( 3.7A)
None
SAM  C7105 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
PRO A7034
LEU A6825
THR A6993
1.77A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA C6870
GLY D4347
LEU C6893
GLY C6871
THR C6908
1.79A18.46
None
None
None
SAM  C7105 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA A6877
SER A6872
ASN A6841
GLY A6875
ARG B4331
1.79A21.90
None
SAM  A7102 ( 4.6A)
SAM  A7102 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.67A21.90
None
SAM  A7102 ( 3.4A)
None
SAM  A7102 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
PRO C7034
LEU C6825
THR C6993
1.74A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
PRO A7049
LEU A7050
THR A6880
1.48A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
PRO C7049
LEU C7050
THR C6880
1.48A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.69A21.90
None
SAM  A7102 ( 3.4A)
None
SAM  A7102 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA C6877
SER C6872
ASN C6841
GLY C6875
ARG D4331
1.77A21.90
None
SAM  C7105 ( 4.4A)
SAM  C7105 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
PRO C  77
LEU C  80
THR C  63
1.08A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
SER A 105
ASN A  33
THR A 109
GLY A 104
GLY A 100
1.76A19.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wcf NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 146
0.96A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wcf NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 149
0.98A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wen NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 149
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wen NSP3
(SARS-CoV-2)		3 / 3
PRO A 136
LEU A 126
THR A 146
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wen NSP3
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 146
0.92A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wiq NSP8
(SARS-CoV-2)		5 / 12
ALA B 150
SER B 151
ASN B 100
LEU B 103
ARG B 190
1.60A16.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA F 336
GLY E 275
THR F 334
GLY F 335
THR E 282
1.74A16.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA C 336
GLY D 275
THR C 334
GLY C 335
THR D 282
1.78A16.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA C6870
GLY D4347
LEU C6893
GLY C6871
THR C6908
1.80A22.94
None
None
None
SAH  C7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA A6877
SER A6872
ASN A6841
GLY A6875
ARG B4331
1.76A
None
SAH  A7102 ( 4.6A)
SAH  A7102 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.70A23.60
None
SAH  A7102 (-3.6A)
None
SAH  A7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER C6903
ASN C6841
THR C6908
GLY C6871
ALA C6870
1.72A23.60
None
SAH  C7102 (-3.7A)
None
SAH  C7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.69A
None
SAH  A7102 (-3.6A)
None
SAH  A7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA C6877
SER C6872
ASN C6841
GLY C6875
ARG D4331
1.75A
None
SAH  C7102 (-4.7A)
SAH  C7102 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER C6903
ASN C6841
THR C6908
GLY C6871
ALA C6870
1.70A
None
SAH  C7102 (-3.7A)
None
SAH  C7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
TYR D 112
PRO D 142
THR C  57
ARG C 107
1.75A17.56
None
None
ZN  D 202 ( 4.7A)
MES  D 201 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
TYR B 112
PRO B 142
THR A  57
ARG A 107
1.58A17.56
None
None
MES  B 201 (-4.7A)
MES  B 201 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.69A
None
FMT  A7104 ( 3.1A)
None
SFG  A7103 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6903
ASN C6841
THR C6908
GLY C6871
ALA C6870
1.72A23.60
None
FMT  C7112 ( 3.3A)
None
SFG  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.70A23.60
None
FMT  A7104 ( 3.1A)
None
SFG  A7103 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA C6870
GLY D4347
LEU C6893
GLY C6871
THR C6908
1.79A22.94
None
None
None
SFG  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6903
ASN C6841
THR C6908
GLY C6871
ALA C6870
1.70A
None
FMT  C7112 ( 3.3A)
None
SFG  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA C6877
SER C6872
ASN C6841
GLY C6875
ARG D4331
1.77A
None
SFG  C7103 ( 4.5A)
FMT  C7112 ( 3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA A6877
SER A6872
ASN A6841
GLY A6875
ARG B4331
1.79A
None
SFG  A7103 ( 4.5A)
FMT  A7104 ( 3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA A6870
GLY B4347
LEU A6893
GLY A6871
THR A6908
1.80A22.94
None
None
None
SFG  A7103 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
SER A 147
SER A 144
HIS A 164
1.16A21.84
None
U5G  A 401 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.77A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.65A20.63
None
None
U5G  A 401 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.66A20.63
None
None
U5G  A 401 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.70A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.01A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO C 136
LEU C 126
THR C 146
1.43A
None
APR  C 201 (-4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO D 125
LEU D 153
THR D 149
1.00A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO D 125
LEU D 153
THR D 146
0.90A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 146
0.96A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO C 125
LEU C 153
THR C 146
0.89A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.69A23.60
None
SO4  A7109 ( 3.2A)
None
SAH  A7101 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA A6870
GLY B4347
LEU A6893
GLY A6871
THR A6908
1.80A22.94
None
None
None
SAH  A7101 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA A6877
SER A6872
ASN A6841
GLY A6875
ARG B4331
1.75A
None
SO4  A7109 (-4.5A)
SO4  A7109 ( 3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6903
ASN A6841
THR A6908
GLY A6871
ALA A6870
1.67A
None
SO4  A7109 ( 3.2A)
None
SAH  A7101 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wqd NSP8
(SARS-CoV-2)		5 / 12
ALA D 150
SER D 151
ASN D 100
LEU D 103
ARG D 190
1.42A16.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wqd NSP8
(SARS-CoV-2)		5 / 12
ALA B 150
SER B 151
ASN B 100
LEU B 103
ARG B 190
1.51A16.38
EDO  B 302 (-3.7A)
None
None
None
EDO  B 302 (-2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 116
SER A 123
GLY B   2
LEU A 141
GLY A 124
1.48A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.25A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A19.53
None
None
DMS  A 405 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.00A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
SER A 147
SER A 144
HIS A 164
1.16A17.36
None
DMS  A 405 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.77A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.37A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A19.53
None
None
DMS  A 405 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ALA D 150
SER D 151
ASN D 100
LEU D 103
ARG D 190
1.68A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ALA B 150
SER B 151
ASN B 100
LEU B 103
ARG B 190
1.53A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		3 / 3
PRO A 128
LEU A  24
THR A  14
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 5
TYR A 132
PRO A 128
LEU A 121
THR A  14
1.80A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
PRO A 337
LEU A 335
THR A 531
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER C  33
SER C  32
HIS A 519
1.57A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER L  33
SER L  32
HIS E 519
1.63A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
SER B 100
GLY A 431
LEU A 387
GLY B  99
THR B 104
1.75A19.13
None
None
DMS  A 905 ( 4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 530
ASN A 334
ASN A 532
LYS E 529
GLY A 526
1.52A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 530
ASN A 334
ASN A 532
LYS E 529
GLY A 526
1.54A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER C  32
SER C  33
HIS A 519
1.04A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER L  32
SER L  33
HIS E 519
1.07A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN A 437
SER A 443
ASN A 439
GLY A 496
ASP A 405
1.34A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN E 437
SER E 443
ASN E 439
GLY E 496
ASP E 405
1.37A19.43
None
None
None
MLI  E 903 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN A 437
SER A 443
ASN A 439
GLY A 496
ASP A 405
1.34A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
SER H 100
GLY E 431
LEU E 387
GLY H  99
THR H 104
1.59A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6ym0 LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER L  32
SER L  33
HIS E 519
1.17A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN E 437
SER E 443
ASN E 439
GLY E 496
ASP E 405
1.27A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN E 437
SER E 443
ASN E 439
GLY E 496
ASP E 405
1.27A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6ym0 LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER L  33
SER L  32
HIS E 519
1.57A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.65A21.65
None
None
P6N  A 502 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.65A21.65
None
None
P6N  A 502 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.95A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN A 437
SER A 443
ASN A 439
GLY A 496
ASP A 405
1.37A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER L  33
SER L  32
HIS E 519
1.64A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER C  32
SER C  33
HIS A 519
1.07A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN E 437
SER E 443
ASN E 439
GLY E 496
ASP E 405
1.36A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER L  32
SER L  33
HIS E 519
1.07A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
SER C  33
SER C  32
HIS A 519
1.63A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.74A21.84
None
PEG  A 405 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.65A21.65
None
None
DMS  A 403 ( 2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
0.95A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.66A21.65
None
None
DMS  A 403 ( 2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO D 125
LEU D 153
THR D 149
1.04A
None
None
EDO  D 203 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 146
0.91A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 149
1.01A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO C 125
LEU C 153
THR C 149
1.01A
None
None
EDO  C 206 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO D 136
LEU D 126
THR D 146
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO E 125
LEU E 153
THR E 146
0.91A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO E 125
LEU E 153
THR E 149
1.00A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 146
0.93A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 149
1.02A
None
None
EDO  A 203 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO C 125
LEU C 153
THR C 146
0.87A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 146
0.94A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO C 125
LEU C 153
THR C 146
0.90A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO C 136
LEU C 126
THR C 146
1.41A
None
APR  C 201 (-4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C  89
GLY C  51
ASN C  37
GLY C  85
PHE D 156
1.77A20.65
None
None
None
None
EDO  D 204 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 146
0.89A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO E 125
LEU E 153
THR E 146
0.92A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO D 136
LEU D 126
THR D 146
1.42A
None
APR  D 201 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 149
1.00A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO A 125
LEU A 153
THR A 146
0.93A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 146
0.92A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO B 125
LEU B 153
THR B 149
1.01A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
PRO B 136
LEU B 126
THR B 146
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.76A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.63
None
None
PJE  C   5 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.63
None
None
PJE  C   5 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		3 / 3
PRO A  39
LEU A  87
THR A  24
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.02A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 558
SER A 561
ASN A 507
ASN A 543
THR A 538
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 558
SER A 561
ASN A 507
ASN A 543
THR A 538
1.77A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A 501
ASN A 507
ASN A 543
THR A 565
ALA A 558
1.61A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
SER A 384
LYS B  97
THR A 402
GLY A 385
ALA A 382
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 383
SER A 384
LYS B  97
GLY A 385
ALA A 382
1.67A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7btf NSP8
(SARS-CoV-2)		3 / 3
PRO D 178
LEU D 180
THR D 137
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 558
SER A 682
GLY A 678
THR A 556
THR A 540
1.68A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 383
SER A 384
LYS B  97
GLY A 385
ALA A 382
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7btf NSP8
(SARS-CoV-2)		5 / 12
ALA D 150
SER D 151
ASN D 100
LEU D 103
ARG D 190
1.79A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 383
SER A 384
LYS B  97
GLY A 385
ALA A 399
1.80A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 383
SER A 384
LYS B  97
GLY A 385
ALA A 399
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.54A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.63
None
None
DMS  A 402 ( 3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 252
LEU A 253
THR A 201
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
GLY A 109
THR A 175
GLY A 174
THR A 135
1.77A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
SER A 113
GLY A  11
LEU A 115
ARG A 298
1.61A21.84
None
DMS  A 406 ( 4.8A)
None
None
DMS  A 406 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		3 / 3
PRO A 241
LEU A 242
THR A 292
1.02A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		3 / 3
SER A 147
SER A 144
HIS A 164
1.18A21.84
None
DMS  A 402 ( 3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
SER A 147
ASN A 119
SER A 144
GLY A 146
GLY A  29
1.64A20.63
None
None
DMS  A 402 ( 3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_2
(BETA-LACTAMASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		3 / 3
PRO A  52
LEU A  57
THR A  24
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 400
SER A 672
SER A 397
ASN A 386
THR A 393
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 501
ASN A 507
ASN A 543
THR A 565
ALA A 558
1.61A15.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 501
ASN A 507
ASN A 543
THR A 565
GLY A 559
1.77A13.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 400
SER A 672
SER A 397
ASN A 386
THR A 393
1.55A15.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.58A15.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 501
ASN A 507
ASN A 543
THR A 565
ALA A 558
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.48A15.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
SER A 681
ASN A 691
SER A 682
THR A 556
GLY A 679
1.78A13.51
None
F86  P 102 (-4.2A)
U  T  10 (-2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 558
SER A 682
GLY A 678
THR A 556
THR A 540
1.79A18.12
None
U  T  10 (-2.9A)
None
None
None