Results

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	RMSD	Seq. Identity (%)	HETATM
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	1q2w	3C-LIKE PROTEASE (SARSr-CoV)	5 / 12	TYR A 239 LEU A 268 ALA A 210 GLU A 288 ALA A 206	1.44A	20.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	1z1i	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 12	TYR A 239 LEU A 268 ALA A 210 GLU A 288 ALA A 206	1.32A	20.91	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	1z1j	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 12	TYR A 239 LEU A 268 ALA A 210 GLU A 288 ALA A 206	1.47A	21.70	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	2a5k	3C-LIKE PEPTIDASE (SARSr-CoV)	5 / 12	TYR B 239 LEU B 268 ALA B 210 GLU B 288 ALA B 206	1.42A	20.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	2acf	REPLICASE POLYPROTEIN 1AB (SARS-COV Tor2)	5 / 12	LEU B 342 LEU B 309 ALA B 220 GLY B 312 GLY B 230	1.50A	20.07	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	2ajf	ACE2 (Homo sapiens)	5 / 12	LEU B 444 LEU B 266 ALA B 264 GLY B 268 GLY B 272	1.48A	19.73	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	2ajf	ACE2 SPIKE PROTEIN (Homo sapiens; SARSr-CoV)	5 / 12	TYR F 481 ILE F 489 ASP B 350 GLU B 37 GLY B 354	1.40A	22.52	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	2alv	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 12	TYR A 239 LEU A 268 ALA A 210 GLU A 288 ALA A 206	1.45A	20.80	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	2amd	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 12	TYR B 239 LEU B 268 ALA B 210 GLU B 288 ALA B 206	1.47A	21.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	2cjr	NUCLEOCAPSID PROTEIN (SARS-COV TW1)	5 / 12	LEU H 292 ALA H 274 ILE G 321 GLY H 285 GLY H 279	1.51A	17.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	2dd8	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	TYR S 410 LEU S 412 ALA S 384 GLY S 418 GLY S 368	1.53A	21.89	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	2fav	REPLICASE POLYPROTEIN 1AB (PP1AB) (ORF1AB) (SARSr-CoV)	5 / 12	LEU C 54 ALA B 103 ALA C 40 GLY C 49 GLY C 47	1.33A	18.51	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	2fe8	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 10	TYR B 137 LEU B 121 LEU B 179 ALA B 205 ALA B 177	1.75A	20.48	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	2ghv	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	TYR E 410 LEU E 412 ALA E 384 ASP E 376 GLY E 418	1.51A	22.47	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	2ghw	ANTI-SCFV ANTIBODY, 80R (Homo sapiens)	5 / 10	LEU B 45 LEU B 165 ALA B 157 ALA B 166 GLY B 231	1.57A	20.67	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	2hsx	LEADER PROTEIN P65 HOMOLOG NSP1 (SARSr-CoV)	5 / 12	LEU A 50 ALA A 27 ALA A 79 VAL A 58 GLY A 19	1.21A	18.53	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	2op9	REPLICASE POLYPROTEIN 1AB (PP1AB, ORF1AB) 3C-LIKE PROTEINASE (3CL-PRO, 3CLP) (SARSr-CoV)	5 / 12	TYR B 239 LEU B 268 ALA B 210 GLU B 288 ALA B 206	1.39A	20.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	2ozk	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	5 / 12	TYR C 178 LEU C 122 ILE C 85 GLU C 145 VAL C 131	1.47A	20.99	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	2qiq	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 12	TYR A 239 LEU A 268 ALA A 210 GLU A 288 ALA A 206	1.43A	20.63	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (SARSr-CoV)	5 / 12	TRP A 124 LEU A 89 ALA A 79 ALA A 107 GLY A 81	1.50A	21.91	None None None None SAH A1293 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	2xyq	PUTATIVE 2'-O-METHYL TRANSFERASE (SARSr-CoV)	5 / 12	TRP A 124 LEU A 89 ALA A 79 ALA A 107 GLY A 81	1.39A	20.61	None None None None SAH A1293 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	2xyr	PUTATIVE 2'-O-METHYL TRANSFERASE (SARSr-CoV)	5 / 12	TRP A 124 LEU A 89 ALA A 79 ALA A 107 GLY A 81	1.51A	21.63	None None None None SFG A1298 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	2xyv	PUTATIVE 2'-O-METHYL TRANSFERASE (SARSr-CoV)	5 / 12	TRP A 124 LEU A 89 ALA A 79 ALA A 107 GLY A 81	1.38A	20.61	None None None None SAH A1300 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	3bgf	SPIKE PROTEIN S1 (SARSr-CoV)	5 / 12	TYR A 410 LEU A 412 ALA A 384 GLY A 418 GLY A 368	1.53A	21.76	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	3d0g	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	TYR E 410 LEU E 412 ALA E 384 GLY E 418 GLY E 368	1.47A	22.52	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	3d0h	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	TYR E 410 LEU E 412 ALA E 384 GLY E 418 GLY E 368	1.49A	22.52	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	3d0h	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 12	LEU A 444 LEU A 266 ALA A 264 GLY A 268 GLY A 272	1.48A	19.30	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	3d0i	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	TYR E 410 LEU E 412 ALA E 384 GLY E 418 GLY E 368	1.49A	22.52	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	3ea7	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 12	TYR A 239 LEU A 268 ALA A 210 GLU A 288 ALA A 206	1.37A	20.91	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	3eaj	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 12	TYR B 239 LEU B 268 ALA B 210 GLU B 288 ALA B 206	1.41A	20.91	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	3mj5	REPLICASE POLYPROTEIN 1A (SARSr-CoV)	5 / 10	TYR B 137 LEU B 121 LEU B 179 ALA B 205 ALA B 177	1.67A	20.48	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	3r24	2'-O-METHYL TRANSFERASE (SARSr-CoV)	5 / 12	TRP A 124 LEU A 89 ALA A 79 ALA A 107 GLY A 81	1.47A	21.35	None None None None SAM A 302 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	3r24	2'-O-METHYL TRANSFERASE (SARSr-CoV)	5 / 12	TRP A 124 LEU A 89 ALA A 79 ALA A 107 GLY A 81	1.40A	19.24	None None None None SAM A 302 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	3sci	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	TYR E 410 LEU E 412 ALA E 384 GLY E 418 GLY E 368	1.55A	21.64	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	3scj	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	TYR E 410 LEU E 412 ALA E 384 GLY E 418 GLY E 368	1.44A	22.52	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	3scj	ACE2 (Homo sapiens)	5 / 12	LEU A 444 LEU A 266 ALA A 264 GLY A 268 GLY A 272	1.49A	19.73	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	3sck	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	TYR F 410 LEU F 412 ALA F 384 GLY F 418 GLY F 368	1.50A	22.52	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	3sck	ACE2 (Paguma larvata; Homo sapiens; SARSr-CoV)	5 / 12	LEU A 444 LEU A 266 ALA A 264 GLY A 268 GLY A 272	1.45A	19.13	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	3scl	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	TYR F 410 LEU F 412 ALA F 384 GLY F 418 GLY F 368	1.49A	22.14	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	3sna	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 12	TYR A 239 LEU A 268 ALA A 210 GLU A 288 ALA A 206	1.42A	20.63	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	4hi3	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 12	TYR B 239 LEU B 268 ALA B 210 GLU B 288 ALA B 206	1.45A	19.76	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	4m0w	REPLICASE POLYPROTEIN 1A UBIQUITIN (Bos taurus; SARSr-CoV)	5 / 12	LEU A 186 ILE A 223 GLU A 204 GLY B 47 GLY A 210	1.60A	21.30	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	4mds	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 12	TYR A 239 LEU A 268 ALA A 210 GLU A 288 ALA A 206	1.38A	19.70	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	4mm3	PAPAIN-LIKE PROTEINASE UBIQUITIN (Homo sapiens; SARSr-CoV)	5 / 12	LEU B 186 ILE B 223 GLU B 204 GLY A 47 GLY B 210	1.53A	22.19	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	5b6o	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 12	TYR B 239 LEU B 268 ALA B 210 GLU B 288 ALA B 206	1.41A	20.72	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	5c5o	3C-LIKE PROTEINASE (SARSr-CoV)	5 / 12	TYR B 239 LEU B 268 ALA B 210 GLU B 288 ALA B 206	1.40A	20.91	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	5c8s	GUANINE-N7 METHYLTRANSFERASE NSP10 (SARSr-CoV)	5 / 12	LEU D 105 ALA C 1 ALA D 100 VAL D 101 GLY C -1	1.20A	18.79	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	5c8s	GUANINE-N7 METHYLTRANSFERASE NSP10 (SARSr-CoV)	5 / 12	LEU D 105 ALA C 1 ALA D 100 VAL D 101 GLY C -1	1.08A	19.70	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	5c8t	GUANINE-N7 METHYLTRANSFERASE NSP10 (SARSr-CoV)	5 / 12	LEU D 105 ALA C 1 ALA D 100 VAL D 101 GLY C -1	1.16A	19.62	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	5c8t	GUANINE-N7 METHYLTRANSFERASE NSP10 (SARSr-CoV)	5 / 12	LEU D 105 ALA C 1 ALA D 100 VAL D 101 GLY C -1	1.30A	18.75	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	5e6j	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 10	TYR D 137 LEU D 121 LEU D 179 ALA D 205 ALA D 177	1.65A	19.83	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	5nfy	POLYPROTEIN 1AB (SARS-COV Frankfurt 1)	5 / 12	LEU A 411 ALA A 281 GLY A 413 CYH A 261 GLY A 416	1.59A	18.54	None None None ZN A 602 (-2.5A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	5rfc	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 12	LEU A 89 LEU A 177 VAL A 86 GLY A 29 GLY A 146	1.69A	20.76	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	5tl6	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 10	TYR B 137 LEU B 121 LEU B 179 ALA B 205 ALA B 177	1.79A	21.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	5wrg	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	LEU A 283 ALA A 658 ALA A 595 VAL A 583 GLY A 298	1.46A	12.64	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	5wrg	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	LEU A 283 ALA A 658 ALA A 595 VAL A 583 GLY A 298	1.17A	11.82	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	5x58	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	5 / 12	ASP C 414 GLU B 730 ALA B 971 VAL B 969 GLY C 400	1.41A	11.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	5x59	S PROTEIN (MERS-CoV)	5 / 12	ILE C1055 GLU B 367 ALA B 368 VAL B 604 GLY B 613	1.45A	11.47	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	5x5b	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	5 / 12	TYR A 200 ALA A 233 ALA A 91 VAL A 98 GLY A 100	1.56A	12.61	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	5x5b	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	5 / 12	ALA A 874 ILE C 891 ASP C1023 GLY C1028 GLY C1026	1.52A	11.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	5xlr	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	TYR C 410 LEU C 412 ALA C 384 GLY C 418 GLY C 368	1.46A	11.82	TYR C 410 ( 1.3A) LEU C 412 ( 0.5A) ALA C 384 ( 0.0A) GLY C 418 ( 0.0A) GLY C 368 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6acd	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	TYR A 410 TRP A 340 LEU A 412 GLY A 418 GLY A 368	1.56A	12.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6acj	ACE2 (Homo sapiens)	5 / 12	TYR D 252 LEU D 248 ALA D 264 VAL D 487 GLY D 448	1.45A	19.02	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6acj	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	TYR A 410 LEU A 412 ALA A 384 GLY A 418 GLY A 368	1.46A	11.91	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ack	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	LEU C 283 ASP C 649 ALA C 658 ALA C 595 GLY C 298	1.46A	11.91	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6crv	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 12	ALA C 874 ILE B 891 ASP B1023 GLY B1028 GLY B1026	1.44A	11.32	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6crx	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 12	ALA C 874 ILE B 891 ASP B1023 GLY B1028 GLY B1026	1.47A	11.76	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6cs0	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 12	TYR B1029 LEU C 876 ALA C 874 GLY C 867 GLY C 862	1.38A	12.43	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6cs2	ACE2 (Homo sapiens)	5 / 12	LEU D 444 LEU D 266 ALA D 264 GLY D 268 GLY D 272	1.49A	19.47	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	6cs2	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 10	TRP B 619 LEU B 615 LEU B 597 ALA B 633 GLY B 580	1.67A	12.43	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6lze	VIRAL PROTEASE (SARS-CoV-2)	5 / 12	LEU A 89 LEU A 177 VAL A 86 GLY A 29 GLY A 146	1.76A	21.73	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6m0j	SPIKE RECEPTOR BINDING DOMAIN (SARS-CoV-2)	5 / 12	TYR E 423 LEU E 425 ALA E 397 GLY E 431 GLY E 381	1.46A	22.22	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6m0k	VIRAL PROTEASE (SARS-CoV-2)	5 / 12	LEU A 89 LEU A 177 VAL A 86 GLY A 29 GLY A 146	1.75A	21.73	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6m17	ACE2 (Homo sapiens)	5 / 12	LEU D 444 LEU D 266 ALA D 264 GLY D 268 GLY D 272	1.59A	17.26	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6m17	RECEPTOR BINDING DOMAIN (SARS-CoV-2)	5 / 12	TYR F 423 LEU F 425 ALA F 397 GLY F 431 GLY F 381	1.31A	23.19	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6m1d	ACE2 (Homo sapiens)	5 / 12	TYR B 83 LEU B 97 ASP B 213 GLU B 87 GLY B 211	1.38A	16.36	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6m1d	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT1 (Homo sapiens)	5 / 12	LEU C 398 ALA C 318 VAL C 317 GLY C 53 GLY C 51	1.10A	17.84	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6m2n	3CL PROTEASE (SARS-CoV-2)	5 / 12	LEU C 89 LEU C 177 VAL C 86 GLY C 29 GLY C 146	1.76A	20.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6m2n	3CL PROTEASE (SARS-CoV-2)	5 / 12	LEU A 89 LEU A 177 VAL A 86 GLY A 29 GLY A 146	1.78A	20.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6m2n	3CL PROTEASE (SARS-CoV-2)	5 / 12	LEU B 89 LEU B 177 VAL B 86 GLY B 29 GLY B 146	1.72A	20.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6m2n	3CL PROTEASE (SARS-CoV-2)	5 / 12	LEU D 89 LEU D 177 VAL D 86 GLY D 29 GLY D 146	1.75A	20.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6m2n	3CL PROTEASE (SARS-CoV-2)	5 / 12	TYR D 239 LEU D 268 ALA D 210 GLU D 288 ALA D 206	1.43A	18.94	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6m2q	3CL PROTEASE (SARS-CoV-2)	5 / 12	LEU A 89 LEU A 177 VAL A 86 GLY A 29 GLY A 146	1.74A	20.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6m3m	NUCLEOCAPSID PROTEIN (SARS-CoV-2)	5 / 12	TYR A 88 LEU A 65 ALA A 174 GLY A 171 GLY A 61	1.54A	18.94	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6m71	NSP12 (SARS-CoV-2)	5 / 12	TYR A 748 LEU A 723 ALA A 777 ILE A 715 GLY A 44	1.52A	14.43	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	6m71	NSP12 (SARS-CoV-2)	5 / 10	HIS A 572 TYR A 689 LEU A 576 ALA A 639 GLY A 485	1.69A	15.84	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6m71	NSP12 (SARS-CoV-2)	5 / 12	LEU A 212 LEU A 186 ALA A 250 ALA A 185 GLY A 179	1.74A	15.84	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6m71	NSP12 (SARS-CoV-2)	5 / 12	TYR A 346 LEU A 329 ALA A 383 ALA A 379 VAL A 341	1.53A	14.43	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6nb6	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	TYR A 410 LEU A 412 ALA A 384 GLY A 418 GLY A 368	1.56A	11.66	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6nur	NSP12 (SARSr-CoV)	5 / 12	HIS A 572 LEU A 576 ILE A 589 ASP A 477 ALA A 639	1.33A	14.11	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6nus	NSP12 NSP8 (SARSr-CoV)	5 / 12	TYR A 374 LEU B 91 LEU B 117 ALA A 399 GLY A 385	1.55A	15.57	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6nus	NSP12 NSP8 (SARSr-CoV)	5 / 12	LEU B 95 LEU B 117 ALA A 399 ALA A 379 GLY A 385	1.22A	20.07	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6vsb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 12	TYR B 695 ALA B 609 VAL B 608 GLY B 311 GLY B 601	1.58A	11.18	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6vsb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 12	LYS A 854 LEU A 861 ILE C 312 GLY C 667 GLY C 669	1.46A	11.13	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6vw1	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 12	TYR F 423 LEU F 425 ALA F 397 GLY F 431 GLY F 381	1.51A	21.98	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6vxs	NSP3 (SARS-CoV-2)	5 / 12	HIS A 94 LEU A 83 ILE B 69 ALA A 39 VAL A 95	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6vxs	NSP3 (SARS-CoV-2)	5 / 12	TYR A 161 LEU A 10 ALA A 21 GLU A 26 GLY A 8	1.67A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6vxs	NSP3 (SARS-CoV-2)	5 / 12	LEU B 43 ALA B 112 ALA B 38 VAL B 95 GLY B 79	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6vxs	NSP3 (SARS-CoV-2)	5 / 12	TYR B 161 LEU B 10 ALA B 21 GLU B 26 GLY B 8	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6vxs	NSP3 (SARS-CoV-2)	5 / 12	LEU B 127 ALA B 112 ALA B 38 VAL B 95 GLY B 79	1.57A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6vxs	NSP3 (SARS-CoV-2)	5 / 12	HIS B 94 LEU B 43 ALA B 52 VAL B 49 GLY B 47	1.73A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6vxs	NSP3 (SARS-CoV-2)	5 / 12	HIS B 94 LEU B 43 ALA B 52 VAL B 49 GLY B 51	1.80A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6vxs	NSP3 (SARS-CoV-2)	5 / 12	LEU A 43 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.78A		None None None None SO4 A 201 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6vxs	NSP3 (SARS-CoV-2)	5 / 12	ILE A 69 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.75A		None None None None SO4 A 201 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6vxs	NSP3 (SARS-CoV-2)	5 / 12	ILE B 69 ALA B 112 ALA B 38 VAL B 95 GLY B 79	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6vxx	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 12	ALA A 892 ILE C 909 ASP C1041 GLY C1046 GLY C1044	1.49A	11.97	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6vyb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 12	ALA B 892 ILE A 720 ASP A1041 GLY A1046 GLY A1044	1.52A	12.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6w02	NSP3 (SARS-CoV-2)	5 / 12	LEU A 160 LEU A 127 ALA A 38 GLY A 130 GLY A 48	1.38A	20.20	None None APR A 201 (-3.4A) APR A 201 (-3.3A) APR A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6w41	SPIKE PROTEIN S1 (SARS-CoV-2)	5 / 12	TYR C 423 TRP C 353 LEU C 425 GLY C 431 GLY C 381	1.71A	19.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6w41	SPIKE PROTEIN S1 (SARS-CoV-2)	5 / 12	TYR C 423 TRP C 353 LEU C 425 GLY C 431 GLY C 381	1.73A	18.12	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6w41	CR3022 FAB HEAVY CHAIN CR3022 FAB LIGHT CHAIN (Homo sapiens)	5 / 12	TYR L 36 LEU H 4 ALA H 78 TRP H 47 GLY H 35	1.70A	19.66	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6w41	SPIKE PROTEIN S1 (SARS-CoV-2)	5 / 12	TYR C 423 LEU C 425 ALA C 397 GLY C 431 GLY C 381	1.44A	19.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	6w41	CR3022 FAB HEAVY CHAIN CR3022 FAB LIGHT CHAIN (Homo sapiens)	5 / 10	TYR L 36 LEU H 4 ALA H 78 TRP H 47 GLY H 35	1.69A	19.66	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	6w4b	NSP9 (SARS-CoV-2)	5 / 10	TYR B 32 LEU B 10 LEU A 10 ALA A 44 GLY A 101	1.78A	19.52	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6w4h	NSP16 (SARS-CoV-2)	5 / 12	TRP A6922 LEU A6887 ALA A6877 ALA A6905 GLY A6879	1.50A	21.67	None None None None SAM A7102 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6w4h	NSP16 (SARS-CoV-2)	5 / 12	TRP A6922 LEU A6887 ALA A6877 ALA A6905 GLY A6879	1.41A	20.77	None None None None SAM A7102 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	TRP A6922 LEU A6887 ALA A6877 ALA A6905 GLY A6879	1.51A		None None None None SAM A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	TRP A6922 LEU A6887 ALA A6877 ALA A6905 GLY A6879	1.40A		None None None None SAM A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	LEU A6981 ILE A6967 ASP A6923 ALA A6960 GLY A6963	1.73A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6w61	2'-O-METHYLTRANSFERA SE NSP10 (SARS-CoV-2)	5 / 12	HIS A6867 LEU A6883 ALA B4324 ALA A6877 GLY B4347	1.56A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6w63	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 12	LEU A 89 LEU A 177 VAL A 86 GLY A 29 GLY A 146	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6w6y	NSP3 (SARS-CoV-2)	5 / 12	TYR A 161 LEU A 10 ALA A 21 GLU A 26 GLY A 8	1.60A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6w6y	NSP3 (SARS-CoV-2)	5 / 12	LEU B 43 ALA B 112 ALA B 38 VAL B 95 GLY B 79	1.75A		None None MES B 201 ( 3.4A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6w6y	NSP3 (SARS-CoV-2)	5 / 12	TYR B 161 LEU B 10 ALA B 21 GLU B 26 GLY B 8	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6w6y	NSP3 (SARS-CoV-2)	5 / 12	TYR A 42 ALA A 112 ALA A 39 VAL A 95 GLY A 78	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6w6y	NSP3 (SARS-CoV-2)	5 / 12	LEU B 160 LEU B 127 ALA B 38 GLY B 130 GLY B 48	1.49A		None None MES B 201 ( 3.4A) MES B 201 ( 3.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6w6y	NSP3 (SARS-CoV-2)	5 / 12	TYR A 161 LEU A 10 ILE B 18 GLU A 26 GLY A 8	1.80A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6w6y	NSP3 (SARS-CoV-2)	5 / 12	ILE B 69 ALA B 112 ALA B 38 VAL B 95 GLY B 79	1.71A		None None MES B 201 ( 3.4A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6w6y	NSP3 (SARS-CoV-2)	5 / 12	ILE A 69 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.74A		None None AMP A 201 ( 3.9A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6w6y	NSP3 (SARS-CoV-2)	5 / 12	LEU A 43 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.73A		None None AMP A 201 ( 3.9A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6w6y	NSP3 (SARS-CoV-2)	5 / 12	LEU A 160 LEU A 127 ALA A 38 GLY A 130 GLY A 48	1.40A		None None AMP A 201 ( 3.9A) AMP A 201 ( 3.5A) AMP A 201 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6w75	NSP16 (SARS-CoV-2)	5 / 12	TRP C6922 LEU C6887 ALA C6877 ALA C6905 GLY C6879	1.48A	18.88	None None None None SAM C7105 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6w75	NSP16 (SARS-CoV-2)	5 / 12	TRP A6922 LEU A6887 ALA A6877 ALA A6905 GLY A6879	1.49A	18.88	None None None None SAM A7102 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6w75	NSP10 NSP16 (SARS-CoV-2)	5 / 12	TYR B4280 ILE B4352 ASP A6904 VAL A6876 GLY B4322	1.60A	16.47	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6w75	NSP10 NSP16 (SARS-CoV-2)	5 / 12	HIS A6867 LEU A6883 ALA B4324 ALA A6877 GLY B4347	1.53A	18.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6w75	NSP10 NSP16 (SARS-CoV-2)	5 / 12	HIS C6867 LEU C6883 ALA D4324 ALA C6877 GLY D4347	1.53A	18.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6w75	NSP10 NSP16 (SARS-CoV-2)	5 / 12	ILE D4291 ASP C6904 ALA C6881 VAL C6842 GLY D4322	1.57A	16.47	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6w75	NSP16 (SARS-CoV-2)	5 / 12	TRP A6922 LEU A6887 ALA A6877 ALA A6905 GLY A6879	1.40A	20.38	None None None None SAM A7102 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6w75	NSP16 (SARS-CoV-2)	5 / 12	TRP C6922 LEU C6887 ALA C6877 ALA C6905 GLY C6879	1.41A	20.38	None None None None SAM C7105 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6w75	NSP10 NSP16 (SARS-CoV-2)	5 / 12	TYR B4280 ILE B4352 ASP A6904 GLY B4323 GLY B4322	1.66A	16.47	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6w75	NSP10 NSP16 (SARS-CoV-2)	5 / 12	ILE B4291 ASP A6904 ALA A6881 VAL A6842 GLY B4322	1.58A	16.47	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6w75	NSP10 NSP16 (SARS-CoV-2)	5 / 12	TYR D4280 ILE D4352 ASP C6904 VAL C6876 GLY D4322	1.59A	16.47	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6wcf	NSP3 (SARS-CoV-2)	5 / 12	TYR A 161 LEU A 10 ALA A 21 GLU A 26 GLY A 8	1.76A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wcf	NSP3 (SARS-CoV-2)	5 / 12	ILE A 69 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.68A		None None MES A 201 (-3.6A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6wcf	NSP3 (SARS-CoV-2)	5 / 12	LEU A 160 LEU A 127 ALA A 38 GLY A 130 GLY A 48	1.60A		None None MES A 201 (-3.6A) MES A 201 (-3.2A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wcf	NSP3 (SARS-CoV-2)	5 / 12	LEU A 43 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.73A		None None MES A 201 (-3.6A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6wen	NSP3 (SARS-CoV-2)	5 / 12	LEU A 160 LEU A 127 ALA A 38 GLY A 130 GLY A 48	1.45A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6wen	NSP3 (SARS-CoV-2)	5 / 12	TYR A 161 LEU A 10 ALA A 21 GLU A 26 GLY A 8	1.68A		None CL A 201 ( 4.8A) None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wen	NSP3 (SARS-CoV-2)	5 / 12	ILE A 69 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wen	NSP3 (SARS-CoV-2)	5 / 12	LEU A 43 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.76A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wey	NSP3 (SARS-CoV-2)	5 / 12	LEU A 247 ALA A 316 ALA A 242 VAL A 299 GLY A 283	1.80A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6wey	NSP3 (SARS-CoV-2)	5 / 12	TYR A 365 LEU A 214 ALA A 225 GLU A 230 GLY A 212	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wey	NSP3 (SARS-CoV-2)	5 / 12	ILE A 273 ALA A 316 ALA A 242 VAL A 299 GLY A 283	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6wjt	2'-O-METHYLTRANSFERA SE NSP10 (SARS-CoV-2)	5 / 12	HIS A6867 LEU A6883 ALA B4324 ALA A6877 GLY B4347	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wjt	2'-O-METHYLTRANSFERA SE NSP10 (SARS-CoV-2)	5 / 12	TYR B4280 ILE B4352 ASP A6904 VAL A6876 GLY B4322	1.59A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	TRP A6922 LEU A6887 ALA A6877 ALA A6905 GLY A6879	1.49A		None None None None SAH A7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6wjt	2'-O-METHYLTRANSFERA SE NSP10 (SARS-CoV-2)	5 / 12	HIS C6867 LEU C6883 ALA D4324 ALA C6877 GLY D4347	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	TRP C6922 LEU C6887 ALA C6877 ALA C6905 GLY C6879	1.48A		None None None None SAH C7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	LEU A6981 ILE A6967 ASP A6923 ALA A6960 GLY A6963	1.69A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wjt	2'-O-METHYLTRANSFERA SE NSP10 (SARS-CoV-2)	5 / 12	ILE B4291 ASP A6904 ALA A6881 VAL A6842 GLY B4322	1.59A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wjt	2'-O-METHYLTRANSFERA SE NSP10 (SARS-CoV-2)	5 / 12	TYR D4280 ILE D4352 ASP C6904 VAL C6876 GLY D4322	1.58A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6wjt	2'-O-METHYLTRANSFERA SE NSP10 (SARS-CoV-2)	5 / 12	TYR D4280 ILE D4352 ASP C6904 GLY D4323 GLY D4322	1.65A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	TRP A6922 LEU A6887 ALA A6877 ALA A6905 GLY A6879	1.39A		None None None None SAH A7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wjt	2'-O-METHYLTRANSFERA SE NSP10 (SARS-CoV-2)	5 / 12	ILE D4291 ASP C6904 ALA C6881 VAL C6842 GLY D4322	1.58A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6wjt	2'-O-METHYLTRANSFERA SE NSP10 (SARS-CoV-2)	5 / 12	TYR B4280 ILE B4352 ASP A6904 GLY B4323 GLY B4322	1.65A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	TRP C6922 LEU C6887 ALA C6877 ALA C6905 GLY C6879	1.43A		None None None None SAH C7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6wkp	NUCLEOCAPSID PROTEIN (SARS-CoV-2)	6 / 12	TYR B 87 LEU B 64 ALA B 173 ASP C 81 GLY B 170 GLY B 60	1.52A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wkq	NSP10 NSP16 (SARS-CoV-2)	5 / 12	ILE B4291 ASP A6904 ALA A6881 VAL A6842 GLY B4322	1.58A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wkq	NSP10 NSP16 (SARS-CoV-2)	5 / 12	ILE D4291 ASP C6904 ALA C6881 VAL C6842 GLY D4322	1.57A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6wkq	NSP10 NSP16 (SARS-CoV-2)	5 / 12	HIS A6867 LEU A6883 ALA B4324 ALA A6877 GLY B4347	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wkq	NSP16 (SARS-CoV-2)	5 / 12	TRP A6922 LEU A6887 ALA A6877 ALA A6905 GLY A6879	1.39A		None None None None SFG A7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6wkq	NSP10 NSP16 (SARS-CoV-2)	5 / 12	TYR D4280 ILE D4352 ASP C6904 GLY D4323 GLY D4322	1.66A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6wkq	NSP16 (SARS-CoV-2)	5 / 12	TRP C6922 LEU C6887 ALA C6877 ALA C6905 GLY C6879	1.47A		None None None None SFG C7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6wkq	NSP16 (SARS-CoV-2)	5 / 12	TRP A6922 LEU A6887 ALA A6877 ALA A6905 GLY A6879	1.49A		None None None None SFG A7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wkq	NSP10 NSP16 (SARS-CoV-2)	5 / 12	TYR B4280 ILE B4352 ASP A6904 VAL A6876 GLY B4322	1.59A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wkq	NSP10 NSP16 (SARS-CoV-2)	5 / 12	TYR D4280 ILE D4352 ASP C6904 VAL C6876 GLY D4322	1.59A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6wkq	NSP10 NSP16 (SARS-CoV-2)	5 / 12	HIS C6867 LEU C6883 ALA D4324 ALA C6877 GLY D4347	1.52A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wkq	NSP16 (SARS-CoV-2)	5 / 12	TRP C6922 LEU C6887 ALA C6877 ALA C6905 GLY C6879	1.41A		None None None None SFG C7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 12	LEU B 190 ILE B 72 ASP B 79 VAL B 183 GLY B 77	1.76A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wnp	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 12	TYR A 239 LEU A 268 ALA A 210 GLU A 288 ALA A 206	1.41A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6wnp	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 12	LEU A 89 LEU A 177 VAL A 86 GLY A 29 GLY A 146	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	LEU A 160 LEU A 127 ALA A 38 GLY A 130 GLY A 48	1.45A		None None APR A 201 (-3.5A) APR A 201 (-3.5A) APR A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	HIS A 94 LEU A 43 ALA A 52 VAL A 49 GLY A 51	1.78A		None None APR A 201 ( 4.2A) APR A 201 (-3.8A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	LEU B 43 ALA B 112 ALA B 38 VAL B 95 GLY B 79	1.74A		None None APR B 201 (-3.3A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	LEU D 43 ALA D 112 ALA D 38 VAL D 95 GLY D 79	1.76A		None None APR D 201 (-3.2A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	HIS D 94 LEU D 43 ALA D 52 VAL D 49 GLY D 47	1.70A		None None APR D 201 ( 4.4A) APR D 201 (-3.6A) APR D 201 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	ILE A 69 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.74A		None None APR A 201 (-3.5A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	LEU B 127 ALA B 112 ALA B 38 VAL B 95 GLY B 79	1.59A		None None APR B 201 (-3.3A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	ILE D 69 ALA D 112 ALA D 38 VAL D 95 GLY D 79	1.72A		None None APR D 201 (-3.2A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	HIS A 86 LEU A 88 ILE A 23 ALA A 60 GLY A 51	1.64A		None None APR A 201 (-4.0A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	LEU B 160 LEU B 127 ALA B 38 GLY B 130 GLY B 48	1.43A		None None APR B 201 (-3.3A) APR B 201 (-3.3A) APR B 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	HIS C 86 LEU C 88 ILE C 23 ALA C 60 GLY C 51	1.65A		None None APR C 201 (-3.9A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	ILE C 69 ALA C 112 ALA C 38 VAL C 95 GLY C 79	1.70A		None None APR C 201 (-3.4A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	TYR B 161 LEU B 10 ALA B 21 GLU B 26 GLY B 8	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	LEU A 43 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.76A		None None APR A 201 (-3.5A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	TYR C 161 LEU C 10 ALA C 21 GLU C 26 GLY C 8	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	LEU C 127 ALA C 112 ALA C 38 VAL C 95 GLY C 79	1.60A		None None APR C 201 (-3.4A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	LEU C 160 LEU C 127 ALA C 38 GLY C 130 GLY C 48	1.44A		None None APR C 201 (-3.4A) APR C 201 (-3.0A) APR C 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	ILE B 69 ALA B 112 ALA B 38 VAL B 95 GLY B 79	1.70A		None None APR B 201 (-3.3A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	LEU D 160 LEU D 127 ALA D 38 GLY D 130 GLY D 48	1.45A		None None APR D 201 (-3.2A) APR D 201 (-3.2A) APR D 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	LEU C 43 ALA C 112 ALA C 38 VAL C 95 GLY C 79	1.74A		None None APR C 201 (-3.4A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	TYR D 161 LEU D 10 ALA D 21 GLU D 26 GLY D 8	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6wq3	2'-O-METHYLTRANSFERA SE NSP10 (SARS-CoV-2)	5 / 12	HIS A6867 LEU A6883 ALA B4324 ALA A6877 GLY B4347	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6wq3	2'-O-METHYLTRANSFERA SE NSP10 (SARS-CoV-2)	5 / 12	TYR B4280 ILE B4352 ASP A6904 GLY B4323 GLY B4322	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6wq3	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	TRP A6922 LEU A6887 ALA A6877 ALA A6905 GLY A6879	1.49A		None None None None SAH A7101 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wq3	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	TRP A6922 LEU A6887 ALA A6877 ALA A6905 GLY A6879	1.41A		None None None None SAH A7101 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wq3	2'-O-METHYLTRANSFERA SE NSP10 (SARS-CoV-2)	5 / 12	ILE B4291 ASP A6904 ALA A6881 VAL A6842 GLY B4322	1.56A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6wqf	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 12	TYR A 239 LEU A 268 ALA A 210 GLU A 288 ALA A 206	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6wqf	3C-LIKE PROTEINASE (SARS-CoV-2)	5 / 12	LEU A 89 LEU A 177 VAL A 86 GLY A 29 GLY A 146	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6y84	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	TYR A 239 LEU A 268 ALA A 210 GLU A 288 ALA A 206	1.44A	18.94	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6yb7	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	LEU A 89 LEU A 177 VAL A 86 GLY A 29 GLY A 146	1.70A	20.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6yb7	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	TYR A 239 LEU A 268 ALA A 210 GLU A 288 ALA A 206	1.43A	19.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6yi3	NUCLEOPROTEIN (SARS-CoV-2)	5 / 12	TYR A 47 LEU A 24 ALA A 133 GLY A 130 GLY A 20	1.41A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 10	TYR L 42 LEU H 4 ALA H 79 TRP H 47 GLY H 35	1.65A	24.09	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6yla	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 12	TYR E 423 LEU E 425 ALA E 397 GLY E 431 GLY E 381	1.51A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 12	ILE B 93 GLU C 171 ALA C 90 VAL C 91 GLY B 44	1.54A		None None None 1PE C 301 (-4.9A) 1PE C 301 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 12	TYR C 42 LEU B 4 ALA B 79 TRP B 47 GLY B 35	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6yla	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 12	TYR A 423 LEU A 425 ALA A 397 GLY A 431 GLY A 381	1.49A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 10	TYR C 42 LEU B 4 ALA B 79 TRP B 47 GLY B 35	1.64A	24.09	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 12	TYR L 42 LEU H 4 ALA H 79 TRP H 47 GLY H 35	1.69A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6ym0	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 12	TYR E 423 LEU E 425 ALA E 397 GLY E 431 GLY E 381	1.50A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ym0	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 12	TYR L 42 LEU H 4 ALA H 79 TRP H 47 GLY H 35	1.65A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	6ym0	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 10	TYR L 42 LEU H 4 ALA H 79 TRP H 47 GLY H 35	1.61A	24.09	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ynq	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	LEU A 89 LEU A 177 VAL A 86 GLY A 29 GLY A 146	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	5 / 12	TYR C 42 LEU B 4 ALA B 79 TRP B 47 GLY B 35	1.69A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	5 / 10	TYR L 42 LEU H 4 ALA H 79 TRP H 47 GLY H 35	1.64A	24.09	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	5 / 10	TYR C 42 LEU B 4 ALA B 79 TRP B 47 GLY B 35	1.65A	24.09	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6yor	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 12	TYR A 423 LEU A 425 ALA A 397 GLY A 431 GLY A 381	1.50A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	5 / 12	TYR L 42 LEU H 4 ALA H 79 TRP H 47 GLY H 35	1.69A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6yor	IGG L CHAIN (Homo sapiens)	5 / 12	TYR L 179 LEU L 11 ALA L 19 ALA L 12 VAL L 13	1.52A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6yor	IGG L CHAIN (Homo sapiens)	5 / 12	TYR C 179 LEU C 11 ALA C 19 ALA C 12 VAL C 13	1.60A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6yor	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 12	TYR E 423 LEU E 425 ALA E 397 GLY E 431 GLY E 381	1.50A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6yt8	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	5 / 12	LEU A 89 LEU A 177 VAL A 86 GLY A 29 GLY A 146	1.69A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU A 160 LEU A 127 ALA A 38 GLY A 130 GLY A 48	1.55A		None EDO A 202 ( 4.8A) EDO A 202 (-3.3A) EDO A 202 ( 4.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	ILE E 69 ALA E 112 ALA E 38 VAL E 95 GLY E 79	1.71A		None None EPE E 202 (-3.3A) None EPE E 203 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS B 94 LEU B 43 ALA B 52 VAL B 49 GLY B 51	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS D 94 LEU D 43 ALA D 52 VAL D 49 GLY D 47	1.77A		None None EDO D 209 (-3.6A) EDO D 209 (-4.6A) EDO D 206 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	TYR B 161 LEU B 10 ALA B 21 GLU B 26 GLY B 8	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU C 43 ALA C 112 ALA C 38 VAL C 95 GLY C 79	1.75A		None None None None EPE C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU B 160 LEU B 127 ALA B 38 GLY B 130 GLY B 48	1.50A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS A 94 LEU A 43 ALA A 52 VAL A 49 GLY A 47	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU E 43 ALA E 112 ALA E 38 VAL E 95 GLY E 79	1.74A		None None EPE E 202 (-3.3A) None EPE E 203 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS E 94 LEU E 43 ALA E 52 VAL E 49 GLY E 47	1.78A		None None None None EPE E 202 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	TYR C 161 LEU C 10 ALA C 21 GLU C 26 GLY C 8	1.74A		None None None None EDO C 203 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU D 43 ALA D 112 ALA D 38 VAL D 95 GLY D 79	1.76A		None None EDO D 205 (-3.5A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	ILE C 69 ALA C 112 ALA C 38 VAL C 95 GLY C 79	1.73A		None None None None EPE C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU B 43 ALA B 112 ALA B 38 VAL B 95 GLY B 79	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU D 160 LEU D 127 ALA D 38 GLY D 130 GLY D 48	1.51A		None None EDO D 205 (-3.5A) EDO D 205 ( 4.9A) EDO D 209 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS C 94 LEU C 43 ALA C 52 VAL C 49 GLY C 47	1.80A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU E 160 LEU E 127 ALA E 38 GLY E 130 GLY E 48	1.55A		None None EPE E 202 (-3.3A) EPE E 202 ( 4.5A) EPE E 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	TYR E 161 LEU E 10 ALA E 21 GLU E 26 GLY E 8	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU C 160 LEU C 127 ALA C 38 GLY C 130 GLY C 48	1.49A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	ILE B 69 ALA B 112 ALA B 38 VAL B 95 GLY B 79	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	ILE A 69 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.70A		None None EDO A 202 (-3.3A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	TYR A 161 LEU A 10 ALA A 21 GLU A 26 GLY A 8	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU A 43 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.73A		None None EDO A 202 (-3.3A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS B 94 LEU B 43 ALA B 52 VAL B 49 GLY B 47	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	ILE D 69 ALA D 112 ALA D 38 VAL D 95 GLY D 79	1.74A		None None EDO D 205 (-3.5A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU B 160 LEU B 127 ALA B 38 GLY B 130 GLY B 48	1.41A		None None APR B 201 (-3.4A) APR B 201 (-3.2A) APR B 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	TYR E 161 LEU E 10 ALA E 21 GLU E 26 GLY E 8	1.77A		EDO E 203 (-4.0A) EDO E 203 ( 4.8A) None None EDO E 203 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	ILE B 69 ALA B 112 ALA B 38 VAL B 95 GLY B 79	1.71A		None None APR B 201 (-3.4A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS D 94 LEU D 43 ALA D 52 VAL D 49 GLY D 51	1.76A		None None EDO D 204 ( 3.7A) APR D 201 (-3.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS A 94 LEU A 43 ALA A 52 VAL A 49 GLY A 47	1.79A		None None APR A 201 ( 4.1A) APR A 201 (-3.7A) APR A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	ILE C 69 ALA C 112 ALA C 38 VAL C 95 GLY C 79	1.72A		None None APR C 201 (-3.4A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS A 94 LEU A 43 ALA A 52 VAL A 49 GLY A 51	1.76A		None None APR A 201 ( 4.1A) APR A 201 (-3.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS C 94 LEU C 43 ALA C 52 VAL C 49 GLY C 51	1.77A		None None APR C 201 ( 4.0A) APR C 201 (-3.6A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU A 43 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.74A		None None APR A 201 (-3.4A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU D 43 ALA D 112 ALA D 38 VAL D 95 GLY D 79	1.75A		None None APR D 201 (-3.3A) None EDO D 203 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	TYR D 9 LEU D 123 ALA D 52 GLU D 25 VAL D 49	1.78A		None None EDO D 204 ( 3.7A) None APR D 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU A 160 LEU A 127 ALA A 38 GLY A 130 GLY A 48	1.40A		None None APR A 201 (-3.4A) APR A 201 ( 3.2A) APR A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU D 160 LEU D 127 ALA D 38 GLY D 130 GLY D 48	1.40A		None None APR D 201 (-3.3A) APR D 201 (-3.2A) EDO D 204 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS B 94 LEU B 43 ALA B 52 VAL B 49 GLY B 51	1.77A		None None APR B 201 ( 4.0A) APR B 201 (-3.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	TYR C 161 LEU C 10 ALA C 21 GLU C 26 GLY C 8	1.76A		EDO C 203 (-4.5A) EDO B 203 (-4.6A) None None EDO C 204 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU E 160 LEU E 127 ALA E 38 GLY E 130 GLY E 48	1.42A		None None APR E 201 (-3.3A) APR E 201 (-3.2A) APR E 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	ILE A 69 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.73A		None None APR A 201 (-3.4A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU C 43 ALA C 112 ALA C 38 VAL C 95 GLY C 79	1.74A		None None APR C 201 (-3.4A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU C 160 LEU C 127 ALA C 38 GLY C 130 GLY C 48	1.41A		None None APR C 201 (-3.4A) APR C 201 (-3.2A) APR C 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	ILE E 69 ALA E 112 ALA E 38 VAL E 95 GLY E 79	1.72A		None None APR E 201 (-3.3A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU B 43 ALA B 112 ALA B 38 VAL B 95 GLY B 79	1.75A		None None APR B 201 (-3.4A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS E 94 LEU E 43 ALA E 52 VAL E 49 GLY E 51	1.77A		None None APR E 201 ( 4.1A) APR E 201 (-3.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	TYR A 161 LEU A 10 ALA A 21 GLU A 26 GLY A 8	1.77A		EDO A 203 (-3.9A) None None None EDO A 202 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS B 94 LEU B 43 ALA B 52 VAL B 49 GLY B 47	1.79A		None None APR B 201 ( 4.0A) APR B 201 (-3.7A) APR B 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU E 43 ALA E 112 ALA E 38 VAL E 95 GLY E 79	1.73A		None None APR E 201 (-3.3A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	ILE D 69 ALA D 112 ALA D 38 VAL D 95 GLY D 79	1.73A		None None APR D 201 (-3.3A) None EDO D 203 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	TYR B 161 LEU B 10 ALA B 21 GLU B 26 GLY B 8	1.76A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU A 160 LEU A 127 ALA A 38 GLY A 130 GLY A 48	1.47A		None None MES A 201 (-3.5A) MES A 201 (-3.1A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	TYR A 161 LEU A 10 ALA A 21 GLU A 26 GLY A 8	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS C 94 LEU C 43 ALA C 52 VAL C 49 GLY C 51	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU C 43 ALA C 112 ALA C 38 VAL C 95 GLY C 79	1.77A		None None MES C 201 (-3.5A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS C 94 LEU C 43 ALA C 52 VAL C 49 GLY C 47	1.75A		None None None None MES C 201 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	TYR B 161 LEU B 10 ALA B 21 GLU B 26 GLY B 8	1.76A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU A 43 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.75A		None None MES A 201 (-3.5A) None EDO A 204 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU C 160 LEU C 127 ALA C 38 GLY C 130 GLY C 48	1.46A		EDO C 203 (-3.7A) None MES C 201 (-3.5A) MES C 201 (-3.3A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	ILE B 69 ALA B 112 ALA B 38 VAL B 95 GLY B 79	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	ILE C 69 ALA C 112 ALA C 38 VAL C 95 GLY C 79	1.73A		None None MES C 201 (-3.5A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU B 43 ALA B 112 ALA B 38 VAL B 95 GLY B 79	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	ILE A 69 ALA A 112 ALA A 38 VAL A 95 GLY A 79	1.72A		None None MES A 201 (-3.5A) None EDO A 204 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	HIS B 94 LEU B 43 ALA B 52 VAL B 49 GLY B 47	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	5 / 12	LEU B 160 LEU B 127 ALA B 38 GLY B 130 GLY B 48	1.51A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	7bqy	MAIN PROTEASE (SARS-CoV-2)	5 / 12	LEU A 89 LEU A 177 VAL A 86 GLY A 29 GLY A 146	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	7btf	NSP12 (SARS-CoV-2)	5 / 12	TYR A 748 LEU A 723 ALA A 777 ILE A 715 GLY A 44	1.49A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	7btf	NSP12 (SARS-CoV-2)	5 / 12	LEU A 212 LEU A 186 ALA A 250 ALA A 185 GLY A 179	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	7btf	NSP12 (SARS-CoV-2)	5 / 12	TYR A 346 LEU A 329 ALA A 383 ALA A 379 VAL A 341	1.48A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	7btf	NSP12 (SARS-CoV-2)	5 / 10	HIS A 572 TYR A 689 LEU A 576 ALA A 639 GLY A 485	1.76A	15.84	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	7buy	VIRUS MAIN PROTEASE (SARS-CoV-2)	5 / 12	LEU A 89 LEU A 177 VAL A 86 GLY A 29 GLY A 146	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	7bv1	NSP12 (SARS-CoV-2)	5 / 12	LEU A 212 LEU A 186 ALA A 250 ALA A 185 GLY A 179	1.64A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	7bv1	NSP12 (SARS-CoV-2)	5 / 12	TYR A 346 LEU A 329 ALA A 383 ALA A 379 VAL A 341	1.44A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_D_15UD402_1 (PROTHROMBIN)	7bv2	NSP12 (SARS-CoV-2)	5 / 12	TYR A 346 LEU A 329 ALA A 383 ALA A 379 VAL A 341	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	7bv2	NSP12 (SARS-CoV-2)	5 / 12	HIS A 725 LEU A 708 ALA A 46 ALA A 43 GLY A 712	1.65A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	7bv2	NSP12 (SARS-CoV-2)	5 / 12	LEU A 212 LEU A 186 ALA A 250 ALA A 185 GLY A 179	1.65A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	7bv2	NSP12 (SARS-CoV-2)	5 / 12	TYR A 748 LEU A 723 ALA A 777 ILE A 715 GLY A 44	1.43A		None