Ligand ID: 15U


Drugbank ID:
DB00278
(Argatroban)


Indication:
Argatroban is indicated for prevention and treatment of thrombosis caused by heparin induced thrombocytopenia (HIT). It is also indicated for use in patients with, or at risk for, HIT who are undergoing percutaneous coronary intervention.

Get human targets for 15U in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '15U' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  89
LEU A 177
VAL A  86
GLY A  29
GLY A 146
1.69A20.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  89
LEU A 177
VAL A  86
GLY A  29
GLY A 146
1.76A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6m0j SPIKE RECEPTOR
BINDING DOMAIN
(SARS-CoV-2)		5 / 12
TYR E 423
LEU E 425
ALA E 397
GLY E 431
GLY E 381
1.46A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  89
LEU A 177
VAL A  86
GLY A  29
GLY A 146
1.75A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		5 / 12
TYR F 423
LEU F 425
ALA F 397
GLY F 431
GLY F 381
1.31A23.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C  89
LEU C 177
VAL C  86
GLY C  29
GLY C 146
1.76A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  89
LEU A 177
VAL A  86
GLY A  29
GLY A 146
1.78A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B  89
LEU B 177
VAL B  86
GLY B  29
GLY B 146
1.72A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU D  89
LEU D 177
VAL D  86
GLY D  29
GLY D 146
1.75A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
TYR D 239
LEU D 268
ALA D 210
GLU D 288
ALA D 206
1.43A18.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  89
LEU A 177
VAL A  86
GLY A  29
GLY A 146
1.74A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
TYR A  88
LEU A  65
ALA A 174
GLY A 171
GLY A  61
1.54A18.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
TYR A 748
LEU A 723
ALA A 777
ILE A 715
GLY A  44
1.52A14.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
HIS A 572
TYR A 689
LEU A 576
ALA A 639
GLY A 485
1.69A15.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
LEU A 186
ALA A 250
ALA A 185
GLY A 179
1.74A15.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
TYR A 346
LEU A 329
ALA A 383
ALA A 379
VAL A 341
1.53A14.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR B 695
ALA B 609
VAL B 608
GLY B 311
GLY B 601
1.58A11.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LYS A 854
LEU A 861
ILE C 312
GLY C 667
GLY C 669
1.46A11.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6vxs NSP3
(SARS-CoV-2)		5 / 12
HIS A  94
LEU A  83
ILE B  69
ALA A  39
VAL A  95
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6vxs NSP3
(SARS-CoV-2)		5 / 12
TYR A 161
LEU A  10
ALA A  21
GLU A  26
GLY A   8
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B  43
ALA B 112
ALA B  38
VAL B  95
GLY B  79
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6vxs NSP3
(SARS-CoV-2)		5 / 12
TYR B 161
LEU B  10
ALA B  21
GLU B  26
GLY B   8
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B 127
ALA B 112
ALA B  38
VAL B  95
GLY B  79
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6vxs NSP3
(SARS-CoV-2)		5 / 12
HIS B  94
LEU B  43
ALA B  52
VAL B  49
GLY B  47
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6vxs NSP3
(SARS-CoV-2)		5 / 12
HIS B  94
LEU B  43
ALA B  52
VAL B  49
GLY B  51
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A  43
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.78A
None
None
None
None
SO4  A 201 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ILE A  69
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.75A
None
None
None
None
SO4  A 201 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ILE B  69
ALA B 112
ALA B  38
VAL B  95
GLY B  79
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA A 892
ILE C 909
ASP C1041
GLY C1046
GLY C1044
1.49A11.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B 892
ILE A 720
ASP A1041
GLY A1046
GLY A1044
1.52A12.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6w02 NSP3
(SARS-CoV-2)		5 / 12
LEU A 160
LEU A 127
ALA A  38
GLY A 130
GLY A  48
1.38A20.20
None
None
APR  A 201 (-3.4A)
APR  A 201 (-3.3A)
APR  A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
TYR C 423
TRP C 353
LEU C 425
GLY C 431
GLY C 381
1.71A19.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
TYR C 423
TRP C 353
LEU C 425
GLY C 431
GLY C 381
1.73A18.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
TYR C 423
LEU C 425
ALA C 397
GLY C 431
GLY C 381
1.44A19.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		6w4b NSP9
(SARS-CoV-2)		5 / 10
TYR B  32
LEU B  10
LEU A  10
ALA A  44
GLY A 101
1.78A19.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6w4h NSP16
(SARS-CoV-2)		5 / 12
TRP A6922
LEU A6887
ALA A6877
ALA A6905
GLY A6879
1.50A21.67
None
None
None
None
SAM  A7102 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6w4h NSP16
(SARS-CoV-2)		5 / 12
TRP A6922
LEU A6887
ALA A6877
ALA A6905
GLY A6879
1.41A20.77
None
None
None
None
SAM  A7102 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TRP A6922
LEU A6887
ALA A6877
ALA A6905
GLY A6879
1.51A
None
None
None
None
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TRP A6922
LEU A6887
ALA A6877
ALA A6905
GLY A6879
1.40A
None
None
None
None
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6981
ILE A6967
ASP A6923
ALA A6960
GLY A6963
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
HIS A6867
LEU A6883
ALA B4324
ALA A6877
GLY B4347
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  89
LEU A 177
VAL A  86
GLY A  29
GLY A 146
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
TYR A 161
LEU A  10
ALA A  21
GLU A  26
GLY A   8
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B  43
ALA B 112
ALA B  38
VAL B  95
GLY B  79
1.75A
None
None
MES  B 201 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
TYR B 161
LEU B  10
ALA B  21
GLU B  26
GLY B   8
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
TYR A  42
ALA A 112
ALA A  39
VAL A  95
GLY A  78
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 160
LEU B 127
ALA B  38
GLY B 130
GLY B  48
1.49A
None
None
MES  B 201 ( 3.4A)
MES  B 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
TYR A 161
LEU A  10
ILE B  18
GLU A  26
GLY A   8
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ILE B  69
ALA B 112
ALA B  38
VAL B  95
GLY B  79
1.71A
None
None
MES  B 201 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ILE A  69
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.74A
None
None
AMP  A 201 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A  43
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.73A
None
None
AMP  A 201 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 160
LEU A 127
ALA A  38
GLY A 130
GLY A  48
1.40A
None
None
AMP  A 201 ( 3.9A)
AMP  A 201 ( 3.5A)
AMP  A 201 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TRP C6922
LEU C6887
ALA C6877
ALA C6905
GLY C6879
1.48A18.88
None
None
None
None
SAM  C7105 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TRP A6922
LEU A6887
ALA A6877
ALA A6905
GLY A6879
1.49A18.88
None
None
None
None
SAM  A7102 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
TYR B4280
ILE B4352
ASP A6904
VAL A6876
GLY B4322
1.60A16.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
HIS A6867
LEU A6883
ALA B4324
ALA A6877
GLY B4347
1.53A18.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
HIS C6867
LEU C6883
ALA D4324
ALA C6877
GLY D4347
1.53A18.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ILE D4291
ASP C6904
ALA C6881
VAL C6842
GLY D4322
1.57A16.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TRP A6922
LEU A6887
ALA A6877
ALA A6905
GLY A6879
1.40A20.38
None
None
None
None
SAM  A7102 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TRP C6922
LEU C6887
ALA C6877
ALA C6905
GLY C6879
1.41A20.38
None
None
None
None
SAM  C7105 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
TYR B4280
ILE B4352
ASP A6904
GLY B4323
GLY B4322
1.66A16.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ILE B4291
ASP A6904
ALA A6881
VAL A6842
GLY B4322
1.58A16.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
TYR D4280
ILE D4352
ASP C6904
VAL C6876
GLY D4322
1.59A16.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6wcf NSP3
(SARS-CoV-2)		5 / 12
TYR A 161
LEU A  10
ALA A  21
GLU A  26
GLY A   8
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ILE A  69
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.68A
None
None
MES  A 201 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A 160
LEU A 127
ALA A  38
GLY A 130
GLY A  48
1.60A
None
None
MES  A 201 (-3.6A)
MES  A 201 (-3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A  43
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.73A
None
None
MES  A 201 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 160
LEU A 127
ALA A  38
GLY A 130
GLY A  48
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6wen NSP3
(SARS-CoV-2)		5 / 12
TYR A 161
LEU A  10
ALA A  21
GLU A  26
GLY A   8
1.68A
None
CL  A 201 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wen NSP3
(SARS-CoV-2)		5 / 12
ILE A  69
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A  43
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 247
ALA A 316
ALA A 242
VAL A 299
GLY A 283
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6wey NSP3
(SARS-CoV-2)		5 / 12
TYR A 365
LEU A 214
ALA A 225
GLU A 230
GLY A 212
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wey NSP3
(SARS-CoV-2)		5 / 12
ILE A 273
ALA A 316
ALA A 242
VAL A 299
GLY A 283
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
HIS A6867
LEU A6883
ALA B4324
ALA A6877
GLY B4347
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
TYR B4280
ILE B4352
ASP A6904
VAL A6876
GLY B4322
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TRP A6922
LEU A6887
ALA A6877
ALA A6905
GLY A6879
1.49A
None
None
None
None
SAH  A7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
HIS C6867
LEU C6883
ALA D4324
ALA C6877
GLY D4347
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TRP C6922
LEU C6887
ALA C6877
ALA C6905
GLY C6879
1.48A
None
None
None
None
SAH  C7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6981
ILE A6967
ASP A6923
ALA A6960
GLY A6963
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ILE B4291
ASP A6904
ALA A6881
VAL A6842
GLY B4322
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
TYR D4280
ILE D4352
ASP C6904
VAL C6876
GLY D4322
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
TYR D4280
ILE D4352
ASP C6904
GLY D4323
GLY D4322
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TRP A6922
LEU A6887
ALA A6877
ALA A6905
GLY A6879
1.39A
None
None
None
None
SAH  A7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ILE D4291
ASP C6904
ALA C6881
VAL C6842
GLY D4322
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
TYR B4280
ILE B4352
ASP A6904
GLY B4323
GLY B4322
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TRP C6922
LEU C6887
ALA C6877
ALA C6905
GLY C6879
1.43A
None
None
None
None
SAH  C7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		6 / 12
TYR B  87
LEU B  64
ALA B 173
ASP C  81
GLY B 170
GLY B  60
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ILE B4291
ASP A6904
ALA A6881
VAL A6842
GLY B4322
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ILE D4291
ASP C6904
ALA C6881
VAL C6842
GLY D4322
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
HIS A6867
LEU A6883
ALA B4324
ALA A6877
GLY B4347
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
TRP A6922
LEU A6887
ALA A6877
ALA A6905
GLY A6879
1.39A
None
None
None
None
SFG  A7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
TYR D4280
ILE D4352
ASP C6904
GLY D4323
GLY D4322
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
TRP C6922
LEU C6887
ALA C6877
ALA C6905
GLY C6879
1.47A
None
None
None
None
SFG  C7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
TRP A6922
LEU A6887
ALA A6877
ALA A6905
GLY A6879
1.49A
None
None
None
None
SFG  A7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
TYR B4280
ILE B4352
ASP A6904
VAL A6876
GLY B4322
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
TYR D4280
ILE D4352
ASP C6904
VAL C6876
GLY D4322
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
HIS C6867
LEU C6883
ALA D4324
ALA C6877
GLY D4347
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
TRP C6922
LEU C6887
ALA C6877
ALA C6905
GLY C6879
1.41A
None
None
None
None
SFG  C7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B 190
ILE B  72
ASP B  79
VAL B 183
GLY B  77
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 239
LEU A 268
ALA A 210
GLU A 288
ALA A 206
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  89
LEU A 177
VAL A  86
GLY A  29
GLY A 146
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 160
LEU A 127
ALA A  38
GLY A 130
GLY A  48
1.45A
None
None
APR  A 201 (-3.5A)
APR  A 201 (-3.5A)
APR  A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  94
LEU A  43
ALA A  52
VAL A  49
GLY A  51
1.78A
None
None
APR  A 201 ( 4.2A)
APR  A 201 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B  43
ALA B 112
ALA B  38
VAL B  95
GLY B  79
1.74A
None
None
APR  B 201 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D  43
ALA D 112
ALA D  38
VAL D  95
GLY D  79
1.76A
None
None
APR  D 201 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS D  94
LEU D  43
ALA D  52
VAL D  49
GLY D  47
1.70A
None
None
APR  D 201 ( 4.4A)
APR  D 201 (-3.6A)
APR  D 201 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A  69
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.74A
None
None
APR  A 201 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 127
ALA B 112
ALA B  38
VAL B  95
GLY B  79
1.59A
None
None
APR  B 201 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE D  69
ALA D 112
ALA D  38
VAL D  95
GLY D  79
1.72A
None
None
APR  D 201 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  86
LEU A  88
ILE A  23
ALA A  60
GLY A  51
1.64A
None
None
APR  A 201 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 160
LEU B 127
ALA B  38
GLY B 130
GLY B  48
1.43A
None
None
APR  B 201 (-3.3A)
APR  B 201 (-3.3A)
APR  B 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS C  86
LEU C  88
ILE C  23
ALA C  60
GLY C  51
1.65A
None
None
APR  C 201 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE C  69
ALA C 112
ALA C  38
VAL C  95
GLY C  79
1.70A
None
None
APR  C 201 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR B 161
LEU B  10
ALA B  21
GLU B  26
GLY B   8
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  43
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.76A
None
None
APR  A 201 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR C 161
LEU C  10
ALA C  21
GLU C  26
GLY C   8
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 127
ALA C 112
ALA C  38
VAL C  95
GLY C  79
1.60A
None
None
APR  C 201 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 160
LEU C 127
ALA C  38
GLY C 130
GLY C  48
1.44A
None
None
APR  C 201 (-3.4A)
APR  C 201 (-3.0A)
APR  C 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE B  69
ALA B 112
ALA B  38
VAL B  95
GLY B  79
1.70A
None
None
APR  B 201 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D 160
LEU D 127
ALA D  38
GLY D 130
GLY D  48
1.45A
None
None
APR  D 201 (-3.2A)
APR  D 201 (-3.2A)
APR  D 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C  43
ALA C 112
ALA C  38
VAL C  95
GLY C  79
1.74A
None
None
APR  C 201 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR D 161
LEU D  10
ALA D  21
GLU D  26
GLY D   8
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
HIS A6867
LEU A6883
ALA B4324
ALA A6877
GLY B4347
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
TYR B4280
ILE B4352
ASP A6904
GLY B4323
GLY B4322
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TRP A6922
LEU A6887
ALA A6877
ALA A6905
GLY A6879
1.49A
None
None
None
None
SAH  A7101 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TRP A6922
LEU A6887
ALA A6877
ALA A6905
GLY A6879
1.41A
None
None
None
None
SAH  A7101 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ILE B4291
ASP A6904
ALA A6881
VAL A6842
GLY B4322
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 239
LEU A 268
ALA A 210
GLU A 288
ALA A 206
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  89
LEU A 177
VAL A  86
GLY A  29
GLY A 146
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6y84 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR A 239
LEU A 268
ALA A 210
GLU A 288
ALA A 206
1.44A18.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  89
LEU A 177
VAL A  86
GLY A  29
GLY A 146
1.70A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR A 239
LEU A 268
ALA A 210
GLU A 288
ALA A 206
1.43A19.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
TYR A  47
LEU A  24
ALA A 133
GLY A 130
GLY A  20
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR E 423
LEU E 425
ALA E 397
GLY E 431
GLY E 381
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR A 423
LEU A 425
ALA A 397
GLY A 431
GLY A 381
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR E 423
LEU E 425
ALA E 397
GLY E 431
GLY E 381
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  89
LEU A 177
VAL A  86
GLY A  29
GLY A 146
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR A 423
LEU A 425
ALA A 397
GLY A 431
GLY A 381
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR E 423
LEU E 425
ALA E 397
GLY E 431
GLY E 381
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  89
LEU A 177
VAL A  86
GLY A  29
GLY A 146
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 160
LEU A 127
ALA A  38
GLY A 130
GLY A  48
1.55A
None
EDO  A 202 ( 4.8A)
EDO  A 202 (-3.3A)
EDO  A 202 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE E  69
ALA E 112
ALA E  38
VAL E  95
GLY E  79
1.71A
None
None
EPE  E 202 (-3.3A)
None
EPE  E 203 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS B  94
LEU B  43
ALA B  52
VAL B  49
GLY B  51
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS D  94
LEU D  43
ALA D  52
VAL D  49
GLY D  47
1.77A
None
None
EDO  D 209 (-3.6A)
EDO  D 209 (-4.6A)
EDO  D 206 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
TYR B 161
LEU B  10
ALA B  21
GLU B  26
GLY B   8
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C  43
ALA C 112
ALA C  38
VAL C  95
GLY C  79
1.75A
None
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 160
LEU B 127
ALA B  38
GLY B 130
GLY B  48
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS A  94
LEU A  43
ALA A  52
VAL A  49
GLY A  47
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E  43
ALA E 112
ALA E  38
VAL E  95
GLY E  79
1.74A
None
None
EPE  E 202 (-3.3A)
None
EPE  E 203 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS E  94
LEU E  43
ALA E  52
VAL E  49
GLY E  47
1.78A
None
None
None
None
EPE  E 202 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
TYR C 161
LEU C  10
ALA C  21
GLU C  26
GLY C   8
1.74A
None
None
None
None
EDO  C 203 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D  43
ALA D 112
ALA D  38
VAL D  95
GLY D  79
1.76A
None
None
EDO  D 205 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE C  69
ALA C 112
ALA C  38
VAL C  95
GLY C  79
1.73A
None
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B  43
ALA B 112
ALA B  38
VAL B  95
GLY B  79
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 160
LEU D 127
ALA D  38
GLY D 130
GLY D  48
1.51A
None
None
EDO  D 205 (-3.5A)
EDO  D 205 ( 4.9A)
EDO  D 209 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS C  94
LEU C  43
ALA C  52
VAL C  49
GLY C  47
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 160
LEU E 127
ALA E  38
GLY E 130
GLY E  48
1.55A
None
None
EPE  E 202 (-3.3A)
EPE  E 202 ( 4.5A)
EPE  E 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
TYR E 161
LEU E  10
ALA E  21
GLU E  26
GLY E   8
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 160
LEU C 127
ALA C  38
GLY C 130
GLY C  48
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B  69
ALA B 112
ALA B  38
VAL B  95
GLY B  79
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE A  69
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.70A
None
None
EDO  A 202 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
TYR A 161
LEU A  10
ALA A  21
GLU A  26
GLY A   8
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A  43
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.73A
None
None
EDO  A 202 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS B  94
LEU B  43
ALA B  52
VAL B  49
GLY B  47
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE D  69
ALA D 112
ALA D  38
VAL D  95
GLY D  79
1.74A
None
None
EDO  D 205 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 160
LEU B 127
ALA B  38
GLY B 130
GLY B  48
1.41A
None
None
APR  B 201 (-3.4A)
APR  B 201 (-3.2A)
APR  B 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
TYR E 161
LEU E  10
ALA E  21
GLU E  26
GLY E   8
1.77A
EDO  E 203 (-4.0A)
EDO  E 203 ( 4.8A)
None
None
EDO  E 203 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B  69
ALA B 112
ALA B  38
VAL B  95
GLY B  79
1.71A
None
None
APR  B 201 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS D  94
LEU D  43
ALA D  52
VAL D  49
GLY D  51
1.76A
None
None
EDO  D 204 ( 3.7A)
APR  D 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS A  94
LEU A  43
ALA A  52
VAL A  49
GLY A  47
1.79A
None
None
APR  A 201 ( 4.1A)
APR  A 201 (-3.7A)
APR  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE C  69
ALA C 112
ALA C  38
VAL C  95
GLY C  79
1.72A
None
None
APR  C 201 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS A  94
LEU A  43
ALA A  52
VAL A  49
GLY A  51
1.76A
None
None
APR  A 201 ( 4.1A)
APR  A 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS C  94
LEU C  43
ALA C  52
VAL C  49
GLY C  51
1.77A
None
None
APR  C 201 ( 4.0A)
APR  C 201 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A  43
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.74A
None
None
APR  A 201 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D  43
ALA D 112
ALA D  38
VAL D  95
GLY D  79
1.75A
None
None
APR  D 201 (-3.3A)
None
EDO  D 203 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
TYR D   9
LEU D 123
ALA D  52
GLU D  25
VAL D  49
1.78A
None
None
EDO  D 204 ( 3.7A)
None
APR  D 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 160
LEU A 127
ALA A  38
GLY A 130
GLY A  48
1.40A
None
None
APR  A 201 (-3.4A)
APR  A 201 ( 3.2A)
APR  A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 160
LEU D 127
ALA D  38
GLY D 130
GLY D  48
1.40A
None
None
APR  D 201 (-3.3A)
APR  D 201 (-3.2A)
EDO  D 204 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS B  94
LEU B  43
ALA B  52
VAL B  49
GLY B  51
1.77A
None
None
APR  B 201 ( 4.0A)
APR  B 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
TYR C 161
LEU C  10
ALA C  21
GLU C  26
GLY C   8
1.76A
EDO  C 203 (-4.5A)
EDO  B 203 (-4.6A)
None
None
EDO  C 204 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 160
LEU E 127
ALA E  38
GLY E 130
GLY E  48
1.42A
None
None
APR  E 201 (-3.3A)
APR  E 201 (-3.2A)
APR  E 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE A  69
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.73A
None
None
APR  A 201 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C  43
ALA C 112
ALA C  38
VAL C  95
GLY C  79
1.74A
None
None
APR  C 201 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 160
LEU C 127
ALA C  38
GLY C 130
GLY C  48
1.41A
None
None
APR  C 201 (-3.4A)
APR  C 201 (-3.2A)
APR  C 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE E  69
ALA E 112
ALA E  38
VAL E  95
GLY E  79
1.72A
None
None
APR  E 201 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B  43
ALA B 112
ALA B  38
VAL B  95
GLY B  79
1.75A
None
None
APR  B 201 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS E  94
LEU E  43
ALA E  52
VAL E  49
GLY E  51
1.77A
None
None
APR  E 201 ( 4.1A)
APR  E 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
TYR A 161
LEU A  10
ALA A  21
GLU A  26
GLY A   8
1.77A
EDO  A 203 (-3.9A)
None
None
None
EDO  A 202 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS B  94
LEU B  43
ALA B  52
VAL B  49
GLY B  47
1.79A
None
None
APR  B 201 ( 4.0A)
APR  B 201 (-3.7A)
APR  B 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E  43
ALA E 112
ALA E  38
VAL E  95
GLY E  79
1.73A
None
None
APR  E 201 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE D  69
ALA D 112
ALA D  38
VAL D  95
GLY D  79
1.73A
None
None
APR  D 201 (-3.3A)
None
EDO  D 203 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
TYR B 161
LEU B  10
ALA B  21
GLU B  26
GLY B   8
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 160
LEU A 127
ALA A  38
GLY A 130
GLY A  48
1.47A
None
None
MES  A 201 (-3.5A)
MES  A 201 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
TYR A 161
LEU A  10
ALA A  21
GLU A  26
GLY A   8
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS C  94
LEU C  43
ALA C  52
VAL C  49
GLY C  51
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C  43
ALA C 112
ALA C  38
VAL C  95
GLY C  79
1.77A
None
None
MES  C 201 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS C  94
LEU C  43
ALA C  52
VAL C  49
GLY C  47
1.75A
None
None
None
None
MES  C 201 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
TYR B 161
LEU B  10
ALA B  21
GLU B  26
GLY B   8
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A  43
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.75A
None
None
MES  A 201 (-3.5A)
None
EDO  A 204 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 160
LEU C 127
ALA C  38
GLY C 130
GLY C  48
1.46A
EDO  C 203 (-3.7A)
None
MES  C 201 (-3.5A)
MES  C 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B  69
ALA B 112
ALA B  38
VAL B  95
GLY B  79
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE C  69
ALA C 112
ALA C  38
VAL C  95
GLY C  79
1.73A
None
None
MES  C 201 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B  43
ALA B 112
ALA B  38
VAL B  95
GLY B  79
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE A  69
ALA A 112
ALA A  38
VAL A  95
GLY A  79
1.72A
None
None
MES  A 201 (-3.5A)
None
EDO  A 204 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS B  94
LEU B  43
ALA B  52
VAL B  49
GLY B  47
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 160
LEU B 127
ALA B  38
GLY B 130
GLY B  48
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  89
LEU A 177
VAL A  86
GLY A  29
GLY A 146
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
TYR A 748
LEU A 723
ALA A 777
ILE A 715
GLY A  44
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
LEU A 186
ALA A 250
ALA A 185
GLY A 179
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
TYR A 346
LEU A 329
ALA A 383
ALA A 379
VAL A 341
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		7btf NSP12
(SARS-CoV-2)		5 / 10
HIS A 572
TYR A 689
LEU A 576
ALA A 639
GLY A 485
1.76A15.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  89
LEU A 177
VAL A  86
GLY A  29
GLY A 146
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
LEU A 186
ALA A 250
ALA A 185
GLY A 179
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
TYR A 346
LEU A 329
ALA A 383
ALA A 379
VAL A 341
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
TYR A 346
LEU A 329
ALA A 383
ALA A 379
VAL A 341
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
HIS A 725
LEU A 708
ALA A  46
ALA A  43
GLY A 712
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
LEU A 186
ALA A 250
ALA A 185
GLY A 179
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
TYR A 748
LEU A 723
ALA A 777
ILE A 715
GLY A  44
1.43A
None