Ligand ID: 115


Drugbank ID:
DB01095
(Fluvastatin)


Indication:
To be used as an adjunct to dietary therapy to prevent cardiovascular events. May be used as secondary prevention in patients with coronary heart disease (CHD) to reduce the risk of requiring coronary revascularization procedures, for reducing progression of coronary atherosclerosis in hypercholesterolemic patients with CHD, and for the treatment of primary hypercholesterolemia and mixed dyslidipidemia.

Get human targets for 115 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '115'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
ASN B  96
LEU B  94
ALA B  43
LEU B  42
1.37A13.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		1ssk NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 9
ASN A  53
LEU A 137
ALA A 151
LEU A  34
LEU A 145
1.63A14.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		1uk4 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
CYH B 128
HIS B 172
LEU B 141
ALA B 116
1.34A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		1uw7 NSP9
(SARS-COV
HKU-39849)		4 / 8
ASN A  96
LEU A  94
ALA A  43
LEU A  42
1.22A15.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.68A19.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.63A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 8
CYH C 325
LEU C 194
ALA C 199
LEU C 192
1.28A16.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 9
CYH B  13
HIS B  41
LEU B  19
LEU B  22
LEU F  96
1.59A11.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH B 265
HIS B 246
LEU B 202
ALA B 206
LEU B 253
1.69A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 8
GLU A  65
HIS A  46
LEU A  44
LEU A  76
1.28A17.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
VAL B  42
ASN B  89
ASP B  38
LYS B  92
1.07A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
VAL C  42
ASN C  89
ASP C  38
LYS C  92
1.18A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 8
SER B 160
ASN A 435
ASP A 480
LYS A 439
1.52A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 7
VAL A 165
SER A 161
ASP A 272
LYS A  70
1.60A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 8
VAL A 165
SER A 161
ASP A 272
LYS A  70
1.72A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2liz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 8
GLU A 240
HIS A 246
LEU A 202
ALA A 206
LEU A 250
1.75A14.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.67A19.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
VAL C 165
SER C 161
ASP C 272
LYS C  70
1.63A21.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
VAL C 165
SER C 161
ASP C 272
LYS C  70
1.51A21.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		4 / 8
GLU A 290
HIS A 172
LEU A 141
ALA A 116
1.26A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2q6g POLYPEPTIDE CHAIN
REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 8
CYH B 145
HIS B 172
ALA D   3
LEU B 167
1.31A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLU A 290
HIS A 172
LEU A 141
ALA A 116
1.29A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.66A19.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
VAL D 165
SER D 161
ASP D 272
LYS D  70
1.63A20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
VAL E 165
SER E 161
ASP E 272
LYS E  70
1.76A20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2w2g NSP3
(SARSr-CoV)		4 / 8
LYS A 524
ASN A 597
ALA A 621
LEU A 648
1.38A19.58
None
SO4  A1653 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		2wct NSP3
(SARSr-CoV)		4 / 7
VAL D 529
SER D 530
ASN B 409
ASP D 639
1.68A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		2xyq NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 8
ARG B  78
SER B  72
VAL A 104
LYS B  10
1.73A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 8
GLU A 240
HIS A 246
LEU A 202
ALA A 206
LEU A 205
1.78A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		3bgf F26G19 FAB
(Mus
musculus)		4 / 8
SER L 174
ASN L 138
ASP L 167
LYS L 169
1.57A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		3bgf F26G19 FAB
(Mus
musculus)		4 / 7
VAL H 183
ASN L 138
ASP L 167
LYS L 169
1.76A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 8
SER A 336
ASN S 435
ASP S 480
LYS S 439
1.06A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 7
VAL S 337
SER S 336
ASN S 437
ASP S 480
1.77A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		3bgf F26G19 FAB
(Mus
musculus)		4 / 7
SER L 174
ASN L 138
ASP L 167
LYS L 169
1.60A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
GLU A 160
LEU A 156
ALA A 251
LEU A 281
1.28A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.68A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
VAL A 114
SER A 113
ASN A 151
ASP A 295
1.74A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		3e9s NSP3
(SARSr-CoV)		4 / 7
VAL A  42
ASN A  89
ASP A  38
LYS A  92
1.09A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		3e9s NSP3
(SARSr-CoV)		4 / 8
VAL A  42
ASN A  89
ASP A  38
LYS A  92
0.90A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3ea8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.66A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.64A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
CYH B 265
HIS B 246
LEU D 202
ALA D 206
LEU B 253
1.65A13.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
ASN B  96
LEU B  94
ALA B  43
LEU B  42
1.43A13.17
PO4  A 123 ( 3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLU A 290
HIS A 172
LEU A 141
ALA A 116
1.35A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH B 265
HIS B 246
LEU B 202
ALA B 206
LEU B 253
1.70A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.66A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.68A19.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH B 265
HIS B 246
LEU D 202
ALA D 206
LEU B 253
1.57A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH B 265
HIS B 246
LEU B 202
ALA B 206
LEU B 253
1.70A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLU A 290
HIS A 172
LEU A 141
ALA A 116
1.10A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.69A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
VAL A  42
ASN A  89
ASP A  38
LYS A  92
1.20A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
VAL A  42
ASN A  89
ASP A  38
LYS A  92
1.05A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		3sci SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
VAL E 337
SER E 336
ASN E 437
ASP E 480
1.76A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		3sci ACE2
(Homo
sapiens)		4 / 8
SER A 167
VAL A 132
ASN A 137
ASP A 136
1.69A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		3sci SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
VAL E 337
SER E 336
ASN E 437
ASP E 480
1.76A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3scj ACE2
(Homo
sapiens)		4 / 8
GLU A 160
LEU A 156
ALA A 251
LEU A 281
1.26A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
SER A 167
VAL A 132
ASN A 137
ASP A 136
1.58A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
GLU A 160
LEU A 156
ALA A 251
LEU A 281
1.27A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.66A19.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.67A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
VAL A  42
ASN A  89
ASP A  38
LYS A  92
1.26A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
VAL A  42
ASN A  89
ASP A  38
LYS A  92
1.09A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.67A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 7
ARG A 102
VAL A  97
ASN A 114
ASP A 121
1.64A20.85
None
OCS  A  98 ( 3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 8
ARG A 102
VAL A  97
ASN A 114
ASP A 121
1.64A20.85
None
OCS  A  98 ( 3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH B 265
HIS B 246
LEU B 202
ALA B 206
LEU B 253
1.64A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.66A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
SER B 503
SER B 407
ASN B 408
ASP B 301
1.68A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
VAL D  42
ASN D  89
ASP D  38
LYS D  92
1.21A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
GLU A 135
ASN A  14
ALA A 150
LEU A  88
1.35A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
VAL D  42
ASN D  89
ASP D  38
LYS D  92
1.01A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_1
(HMG-COA REDUCTASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 9
SER C 503
VAL C 405
SER C 407
ASN C 408
ASP C 301
1.46A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 7
VAL C 405
SER C 407
ASN C 408
ASP C 301
1.33A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 8
SER C 503
VAL C 405
SER C 407
ASN C 408
ASP C 301
1.44A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLU A 270
ASN A 274
LEU A 272
ALA A 234
1.77A17.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLU A 270
ASN A 274
LEU A 272
ALA A 234
1.76A17.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		5x59 S PROTEIN
(MERS-CoV)		4 / 8
CYH B 736
HIS C 836
ASN C 839
LEU B 347
1.40A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5x59 S PROTEIN
(MERS-CoV)		4 / 8
SER C 643
VAL C 374
SER C 598
LYS C 381
1.68A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		5x59 S PROTEIN
(MERS-CoV)		4 / 7
VAL C 661
SER C 362
ASN A 832
LYS A 933
1.80A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
SER B 386
VAL B 496
ASN B 424
ASP B 429
1.61A16.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 7
VAL B 337
SER B 336
ASN B 437
ASP B 480
1.75A16.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
VAL A  42
ASN A  89
ASP A  38
LYS A  92
0.90A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
VAL A  42
ASN A  89
ASP A  38
LYS A  92
1.11A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		4 / 8
SER B 949
VAL B 945
ASN b  12
ASP b   9
1.70A11.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 9
ASN A 935
LEU a  18
ALA B 926
LEU A 927
LEU B 927
1.68A11.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		6acg ACE2
(Homo
sapiens)		5 / 9
GLU D 589
LEU D 591
ALA D 443
LEU D 440
LEU D 240
1.64A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
GLU B 755
LYS C1010
ALA C1002
LEU C1006
1.22A17.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
VAL A1104
SER A1105
ASN C 896
ASP A1109
1.41A17.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
VAL A1104
SER A1105
ASN C 896
ASP A1109
1.41A17.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ARG C 232
VAL C 102
ASN C  78
ASP C 134
1.58A17.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ARG B 977
VAL B 973
ASN B 951
ASP C 976
1.66A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
SER B 358
VAL B 354
SER B 353
LYS B 371
1.54A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6jyt HELICASE
(SARSr-CoV)		4 / 8
VAL B 452
SER B 453
ASN B 459
ASP B 458
1.69A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6jyt HELICASE
(SARSr-CoV)		4 / 7
ARG A  15
SER A  44
ASN A  46
ASP B  56
1.65A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
VAL B 350
SER B 349
ASN B 450
ASP B 442
1.70A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
GLU A 240
HIS A 246
ALA A 206
LEU A 205
1.45A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
GLU A 240
HIS A 246
ALA A 206
LEU A 205
1.43A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
GLU A 240
HIS A 246
ALA A 206
LEU A 205
1.45A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6m17 ACE2
(Homo
sapiens)		4 / 8
SER B 167
VAL B 691
SER B 692
ASN B 159
1.67A18.71
None
None
None
NAG  B 913 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		6m1d ACE2
(Homo
sapiens)		5 / 9
ASN D 103
LEU D 100
ALA D  80
LEU D  97
LEU D  29
1.49A18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 9
CYH C 500
LEU C  85
ALA C 282
LEU C 281
LEU C 494
1.61A21.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 8
CYH C 463
LEU C 201
ALA C 202
LEU C 198
1.41A21.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m1d ACE2
(Homo
sapiens)		4 / 8
ASN D  33
LEU D 391
ALA D  99
LEU D 100
1.27A18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.31A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.14A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m71 NSP7
(SARS-CoV-2)		4 / 8
CYH C   8
HIS C  36
ALA C  42
LEU C  41
1.52A11.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.30A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 672
VAL A 398
SER A 397
ASP A 390
1.51A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.33A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.15A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.35A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.39A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.15A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.38A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6m71 NSP7
(SARS-CoV-2)		4 / 8
CYH C   8
HIS C  36
ALA C  42
LEU C  41
1.50A11.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6m71 NSP7
(SARS-CoV-2)		4 / 8
CYH C   8
HIS C  36
ALA C  42
LEU C  41
1.51A11.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.36A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		5 / 9
ASN A 312
LEU A 316
ALA A 250
LEU A 251
LEU A 186
1.59A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.33A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.31A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
SER A 386
VAL A 496
ASN A 424
ASP A 429
1.72A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL L 168
SER L 179
ASN L 142
ASP L 172
1.37A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL H 196
ASN L 143
ASP L 172
LYS L 174
1.76A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL H 196
ASN L 143
ASP L 172
LYS L 174
1.72A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 168
SER L 179
ASN L 142
ASP L 172
1.25A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		6nur NSP12
(SARSr-CoV)		5 / 9
ASN A 312
LEU A 316
ALA A 250
LEU A 251
LEU A 186
1.54A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6nur NSP7
NSP8
(SARSr-CoV)		4 / 8
CYH D 114
ASN C  69
LEU C  60
LEU C  56
1.42A17.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6nur NSP12
NSP7
(SARSr-CoV)		4 / 8
SER C  15
VAL C  11
ASN A 416
LYS A 849
1.58A11.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6nur NSP7
(SARSr-CoV)		5 / 8
CYH C   8
HIS C  36
LEU C  40
ALA C  42
LEU C  41
1.78A11.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6nus NSP12
(SARSr-CoV)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.12A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
CYH C 738
ASN C 856
LEU C 858
LEU C 959
1.36A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER B 383
SER C 982
ASN B 542
ASP B 389
1.60A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vw1 ACE2
(Homo
sapiens)		4 / 8
GLU B 160
LEU B 156
ALA B 251
LEU B 281
1.29A20.26
None
EDO  B 705 ( 4.9A)
None
EDO  B 705 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6vw1 ACE2
(Homo
sapiens)		4 / 8
SER A 167
VAL A 132
ASN A 137
ASP A 136
1.72A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
VAL B 166
SER B 162
ASP B 273
LYS B  71
1.53A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
VAL B 166
SER B 162
ASP B 273
LYS B  71
1.65A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.28A
None
None
None
SO4  B 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.29A
None
None
None
SO4  B 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.40A
None
None
None
SO4  B 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.41A
None
None
None
SO4  B 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.40A
None
None
None
SO4  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.40A
None
None
None
SO4  B 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.39A
None
None
None
SO4  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.49A
None
None
None
SO4  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.28A
None
None
None
SO4  B 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.39A
None
None
None
SO4  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.48A
None
None
None
SO4  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.49A
None
None
None
SO4  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASN C  30
LEU C 216
ALA C  93
LEU C 189
1.33A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASN B  30
LEU B 216
ALA B  93
LEU B 189
1.24A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
VAL L 163
SER L 174
ASN L 137
ASP L 167
1.32A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
VAL L 163
SER L 174
ASN L 137
ASP L 167
1.21A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
VAL L 163
SER L 174
ASN L 137
ASP L 167
1.21A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
ARG C 457
SER C 459
ASN C 422
ASP C 467
1.64A15.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w4b NSP9
(SARS-CoV-2)		4 / 8
ASN B  97
LEU B  95
ALA B  44
LEU B  43
1.43A13.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6w4h NSP16
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.77A22.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
HIS A7023
ALA A7002
LEU A7004
1.74A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
HIS A7023
ALA A7002
LEU A7004
1.74A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLU A 240
HIS A 246
ALA A 206
LEU A 205
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLU A 240
HIS A 246
ALA A 206
LEU A 205
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLU A 240
HIS A 246
ALA A 206
LEU A 205
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
ALA B  89
LEU B  88
1.71A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH A  92
HIS A 119
LEU A 122
ALA A 124
1.66A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
ALA A  89
LEU A  88
1.70A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH B  92
HIS B 119
LEU B 122
ALA B 124
1.65A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
ALA B  89
LEU B  88
1.71A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH B  92
HIS B 119
LEU B 122
ALA B 124
1.64A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
ALA A  89
LEU A  88
1.70A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH B 143
ASN B 117
LEU B 122
ALA B 124
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH B 143
ASN B 117
LEU B 122
ALA B 124
1.62A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH A  92
HIS A 119
LEU A 122
ALA A 124
1.73A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH B 143
ASN B 117
LEU B 122
ALA B 124
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
ALA A 124
LEU A 153
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
LEU A 122
ALA A 124
1.77A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
ALA A 124
LEU A 153
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.63A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH B  92
HIS B 119
LEU B 122
ALA B 124
1.71A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
LEU A 122
ALA A 124
1.76A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
ALA A  89
LEU A  88
1.71A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH A  92
HIS A 119
LEU A 122
ALA A 124
1.67A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.62A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
ALA A 124
LEU A 153
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
ALA B  89
LEU B  88
1.72A16.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.47A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.50A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.80A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.51A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.79A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.47A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.47A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.50A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
CYH C 155
LEU C 113
ALA C 116
LEU C 117
1.00A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
VAL A  41
ASN A  88
ASP A  37
LYS A  91
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
VAL C  41
ASN C  88
ASP C  37
LYS C  91
0.93A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
CYH C 155
LEU C 113
ALA C 116
LEU C 117
1.02A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
VAL A  41
ASN A  88
ASP A  37
LYS A  91
1.10A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
VAL B  41
ASN B  88
ASP B  37
LYS B  91
0.95A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
VAL A  41
ASN A  88
ASP A  37
LYS A  91
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
CYH C 155
LEU C 113
ALA C 116
LEU C 117
0.99A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
CYH B 155
LEU B 113
ALA B 116
LEU B 117
1.10A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 8
ASN A  96
LEU A  94
ALA A  43
LEU A  42
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 8
ASN A  96
LEU A  94
ALA A  43
LEU A  42
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 8
ASN A  96
LEU A  94
ALA A  43
LEU A  42
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
HIS A 138
LEU A 109
ALA A 112
LEU A 127
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
HIS A 138
LEU A 109
ALA A 112
LEU A 127
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
CYH A 143
ASN A 117
LEU A 122
ALA A 124
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wen NSP3
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
GLU A 268
HIS A 249
LEU A 247
LEU A 279
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
GLU A 268
HIS A 249
LEU A 247
LEU A 279
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
GLU A 268
HIS A 298
LEU A 247
LEU A 279
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
HIS A 342
LEU A 313
ALA A 316
LEU A 331
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
GLU A 268
HIS A 249
LEU A 247
LEU A 279
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
CYH A 347
ASN A 321
LEU A 326
ALA A 328
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
HIS A 342
LEU A 313
ALA A 316
LEU A 331
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
CYH A 347
ASN A 321
LEU A 326
ALA A 328
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
GLU A 268
HIS A 298
LEU A 247
LEU A 279
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
GLU A 268
HIS A 298
LEU A 247
LEU A 279
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
CYH A 347
ASN A 321
LEU A 326
ALA A 328
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
SER F 312
VAL E 270
ASN B 345
ASP E 297
1.61A11.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
VAL C6965
SER C6964
ASN C7008
ASP C6923
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.80A22.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
CYH C6823
ASN C6941
ALA C7002
LEU C7004
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
VAL A 166
SER A 162
ASP A 273
LYS A  71
1.71A19.01
None
EDO  A 408 ( 3.7A)
EDO  A 408 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
VAL A 166
SER A 162
ASP A 273
LYS A  71
1.60A
None
EDO  A 408 ( 3.7A)
EDO  A 408 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
VAL B 166
SER B 162
ASP B 273
LYS B  71
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
VAL B 166
SER B 162
ASP B 273
LYS B  71
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
VAL A 166
SER A 162
ASP A 273
LYS A  71
1.59A
None
EDO  A 408 ( 3.7A)
EDO  A 408 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
VAL B 166
SER B 162
ASP B 273
LYS B  71
1.71A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
ALA A 124
LEU A 153
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
ALA A 124
LEU A 153
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
CYH C 143
ASN C 117
LEU C 122
ALA C 124
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A 114
ASN A 117
ALA A 124
LEU A 153
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
VAL A6965
SER A6964
ASN A7008
ASP A6923
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.59A
GTA  A7102 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.59A
GTA  A7102 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
CYH A6823
ASN A6941
ALA A7002
LEU A7004
1.59A
GTA  A7102 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
HIS A  36
LEU A  40
ALA D  86
LEU A  41
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
HIS A  36
LEU A  40
ALA D  86
LEU A  41
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
HIS A  36
LEU A  40
ALA D  86
LEU A  41
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
CYH A 284
ASN A  99
LEU A 118
ALA A 114
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
CYH A 284
ASN A  99
LEU A 118
ALA A 114
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
ASN A 128
LEU A 132
ALA A 135
LEU A 150
1.61A
PO4  A 504 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
CYH A 284
ASN A  99
LEU A 118
ALA A 114
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
VAL A  41
ASN A  88
ASP A  37
LYS A  91
0.92A19.50
None
GOL  A 507 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
ASN A 128
LEU A 132
ALA A 135
LEU A 150
1.61A
PO4  A 504 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
ASN A 128
LEU A 132
ALA A 135
LEU A 150
1.60A
PO4  A 504 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A 270
ASN A 274
LEU A 272
ALA A 234
1.79A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLU A 270
ASN A 274
LEU A 272
ALA A 234
1.78A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
HIS C  36
LEU C  40
ALA B  86
LEU C  41
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
HIS A  36
LEU A  40
ALA D  86
LEU A  41
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
HIS A  36
LEU A  40
ALA D  86
LEU A  41
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
HIS C  36
LEU C  40
ALA B  86
LEU C  41
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
HIS A  36
LEU A  40
ALA D  86
LEU A  41
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
HIS C  36
LEU C  40
ALA B  86
LEU C  41
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
ASN A  35
LEU A 119
ALA A 133
LEU A  16
0.96A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
ASN A  35
LEU A 119
ALA A 133
LEU A  16
0.96A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
ASN A  35
LEU A 119
ALA A 133
LEU A  16
0.96A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 9
ASN A  35
LEU A 119
ALA A 133
LEU A  16
LEU A 127
1.09A14.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 143
ASP C 173
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 144
ASP C 173
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL B 186
ASN C 144
ASP C 173
LYS C 175
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL C 169
SER C 180
ASN C 143
ASP C 173
1.38A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL B 186
ASN C 144
ASP C 173
LYS C 175
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 144
ASP C 173
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
SER C 180
ASN C 144
ASP C 173
LYS C 175
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
SER C 180
ASN C 144
ASP C 173
LYS C 175
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 143
ASP C 173
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.60A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.38A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
SER C 180
ASN C 144
ASP C 173
LYS C 175
1.76A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL C 169
SER C 180
ASN C 144
ASP C 173
1.57A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL B 186
ASN C 144
ASP C 173
LYS C 175
1.79A17.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
SER L 180
ASN L 144
ASP L 173
LYS L 175
1.59A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
SER L 180
ASN L 144
ASP L 173
LYS L 175
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.42A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.60A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
SER L 180
ASN L 144
ASP L 173
LYS L 175
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
VAL C 169
SER C 180
ASN C 143
ASP C 173
1.37A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 143
ASP C 173
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.60A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 143
ASP C 173
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 144
ASP C 173
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 144
ASP C 173
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
VAL C 169
SER C 180
ASN C 144
ASP C 173
1.60A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.38A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.33A
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.35A
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  45
LEU E  43
LEU E  75
1.33A
None
None
None
EPE  E 203 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.34A
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH E 143
ASN E 117
LEU E 122
ALA E 124
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  94
LEU E  43
LEU E  75
1.34A
None
None
None
EPE  E 203 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
HIS B 138
LEU B 109
ALA B 112
LEU B 127
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH B 143
ASN B 117
LEU B 122
ALA B 124
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH B 143
ASN B 117
LEU B 122
ALA B 124
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  45
LEU E  43
LEU E  75
1.32A
None
None
None
EPE  E 203 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  94
LEU E  43
LEU E  75
1.35A
None
None
None
EPE  E 203 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH C 143
ASN C 117
LEU C 122
ALA C 124
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
HIS C 138
LEU C 109
ALA C 112
LEU C 127
1.57A
EDO  C 208 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
HIS B 138
LEU B 109
ALA B 112
LEU B 127
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH D 143
ASN D 117
LEU D 122
ALA D 124
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH B 143
ASN B 117
LEU B 122
ALA B 124
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH E 143
ASN E 117
LEU E 122
ALA E 124
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  45
LEU E  43
LEU E  75
1.32A
None
None
None
EPE  E 203 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.33A
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  94
LEU E  43
LEU E  75
1.34A
None
None
None
EPE  E 203 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
CYH E 143
ASN E 117
LEU E 122
ALA E 124
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.33A
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.35A
None
None
None
EPE  C 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
HIS C 138
LEU C 109
ALA C 112
LEU C 127
1.57A
EDO  C 208 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  45
LEU E  43
LEU E  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.28A
None
None
None
EDO  D 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  94
LEU E  43
LEU E  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  94
LEU E  43
LEU E  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.28A
None
None
None
EDO  D 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  94
LEU D  43
LEU D  75
1.30A
None
None
None
EDO  D 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  45
LEU E  43
LEU E  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  45
LEU E  43
LEU E  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.39A
None
None
None
EDO  D 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.39A
None
None
None
EDO  D 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU E  64
HIS E  94
LEU E  43
LEU E  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU D  64
HIS D  45
LEU D  43
LEU D  75
1.40A
None
None
None
EDO  D 202 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  94
LEU C  43
LEU C  75
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  94
LEU B  43
LEU B  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  94
LEU A  43
LEU A  75
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU B  64
HIS B  45
LEU B  43
LEU B  75
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU A  64
HIS A  45
LEU A  43
LEU A  75
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
GLU C  64
HIS C  45
LEU C  43
LEU C  75
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 8
CYH A 659
HIS A 572
ASN A 568
LEU A 638
ALA A 634
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 8
CYH A 659
HIS A 572
ASN A 568
LEU A 638
ALA A 634
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 8
CYH A 659
HIS A 572
ASN A 568
LEU A 638
ALA A 634
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 9
CYH A 659
HIS A 572
ASN A 568
LEU A 638
ALA A 634
1.68A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.56A
 ZN  A1002 (-2.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		5 / 9
ASN A 312
LEU A 316
ALA A 250
LEU A 251
LEU A 186
1.58A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLU A 665
LEU A 673
ALA A 382
LEU A 401
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.56A
 ZN  A1002 (-2.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7btf NSP8
(SARS-CoV-2)		4 / 8
ASN D 176
LEU D 180
ALA D 181
LEU D 184
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.55A
 ZN  A1002 (-2.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLU A 665
LEU A 673
ALA A 382
LEU A 401
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
HIS A 572
ASN A 568
LEU A 638
ALA A 634
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.62A
 ZN  A1002 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		4 / 8
VAL C  16
SER C  15
ASN A 414
LYS A 417
1.67A11.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.61A
 ZN  A1002 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv1 NSP8
(SARS-CoV-2)		4 / 8
CYH D 142
ASN D 109
ALA D 188
LEU D 128
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 9
ASN A 312
LEU A 316
ALA A 250
LEU A 251
LEU A 186
1.73A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		4 / 7
VAL C  16
SER C  15
ASN A 414
LYS A 417
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.61A
 ZN  A1002 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		4 / 7
VAL C  16
SER C  15
ASN A 414
LYS A 417
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv1 NSP8
(SARS-CoV-2)		4 / 8
CYH D 142
ASN D 109
ALA D 188
LEU D 128
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv1 NSP8
(SARS-CoV-2)		4 / 8
CYH D 142
ASN D 109
ALA D 188
LEU D 128
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv1 NSP8
(SARS-CoV-2)		4 / 8
ASN D 176
LEU D 180
ALA D 181
LEU D 184
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
HIS A 572
ASN A 568
LEU A 638
ALA A 634
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
HIS A 572
ASN A 568
LEU A 638
ALA A 634
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.55A
 ZN  A1002 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		4 / 8
VAL C  16
SER C  15
ASN A 414
LYS A 849
1.68A11.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		4 / 7
VAL C  16
SER C  15
ASN A 414
LYS A 849
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
LEU A 638
ALA A 634
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
GLU A 610
HIS A 752
ALA A 771
LEU A 775
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
GLU A 610
HIS A 752
ALA A 771
LEU A 775
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
ASN A 568
ALA A 634
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASN A 312
LEU A 316
ALA A 250
LEU A 251
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
LEU A 638
ALA A 634
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.54A
 ZN  A1002 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 487
LEU A 575
ALA A 639
LEU A 638
1.54A
 ZN  A1002 (-2.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
CYH A 659
HIS A 572
LEU A 638
ALA A 634
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		4 / 7
VAL C  16
SER C  15
ASN A 414
LYS A 849
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 9
ASN A 312
LEU A 316
ALA A 250
LEU A 251
LEU A 186
1.62A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
GLU A 658
CYH A 659
ALA A 311
LEU A 308
1.58A
None