Ligand ID: 115


Drugbank ID:
DB01095
(Fluvastatin)


Indication:
To be used as an adjunct to dietary therapy to prevent cardiovascular events. May be used as secondary prevention in patients with coronary heart disease (CHD) to reduce the risk of requiring coronary revascularization procedures, for reducing progression of coronary atherosclerosis in hypercholesterolemic patients with CHD, and for the treatment of primary hypercholesterolemia and mixed dyslidipidemia.

Get human targets for 115 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '115' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
ASN B  96
LEU B  94
ALA B  43
LEU B  42
1.37A13.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		1ssk NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 9
ASN A  53
LEU A 137
ALA A 151
LEU A  34
LEU A 145
1.63A14.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		1uk4 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
CYH B 128
HIS B 172
LEU B 141
ALA B 116
1.34A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		1uw7 NSP9
(SARS-COV
HKU-39849)		4 / 8
ASN A  96
LEU A  94
ALA A  43
LEU A  42
1.22A15.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.68A19.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.63A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 8
CYH C 325
LEU C 194
ALA C 199
LEU C 192
1.28A16.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 9
CYH B  13
HIS B  41
LEU B  19
LEU B  22
LEU F  96
1.59A11.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH B 265
HIS B 246
LEU B 202
ALA B 206
LEU B 253
1.69A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 8
GLU A  65
HIS A  46
LEU A  44
LEU A  76
1.28A17.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
VAL B  42
ASN B  89
ASP B  38
LYS B  92
1.07A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
VAL C  42
ASN C  89
ASP C  38
LYS C  92
1.18A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 8
SER B 160
ASN A 435
ASP A 480
LYS A 439
1.52A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 7
VAL A 165
SER A 161
ASP A 272
LYS A  70
1.60A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 8
VAL A 165
SER A 161
ASP A 272
LYS A  70
1.72A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2liz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 8
GLU A 240
HIS A 246
LEU A 202
ALA A 206
LEU A 250
1.75A14.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.67A19.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
VAL C 165
SER C 161
ASP C 272
LYS C  70
1.63A21.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
VAL C 165
SER C 161
ASP C 272
LYS C  70
1.51A21.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		4 / 8
GLU A 290
HIS A 172
LEU A 141
ALA A 116
1.26A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2q6g POLYPEPTIDE CHAIN
REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 8
CYH B 145
HIS B 172
ALA D   3
LEU B 167
1.31A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLU A 290
HIS A 172
LEU A 141
ALA A 116
1.29A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.66A19.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
VAL D 165
SER D 161
ASP D 272
LYS D  70
1.63A20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
VAL E 165
SER E 161
ASP E 272
LYS E  70
1.76A20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		2w2g NSP3
(SARSr-CoV)		4 / 8
LYS A 524
ASN A 597
ALA A 621
LEU A 648
1.38A19.58
None
SO4  A1653 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		2wct NSP3
(SARSr-CoV)		4 / 7
VAL D 529
SER D 530
ASN B 409
ASP D 639
1.68A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		2xyq NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 8
ARG B  78
SER B  72
VAL A 104
LYS B  10
1.73A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 8
GLU A 240
HIS A 246
LEU A 202
ALA A 206
LEU A 205
1.78A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		3bgf F26G19 FAB
(Mus
musculus)		4 / 8
SER L 174
ASN L 138
ASP L 167
LYS L 169
1.57A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		3bgf F26G19 FAB
(Mus
musculus)		4 / 7
VAL H 183
ASN L 138
ASP L 167
LYS L 169
1.76A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 8
SER A 336
ASN S 435
ASP S 480
LYS S 439
1.06A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 7
VAL S 337
SER S 336
ASN S 437
ASP S 480
1.77A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		3bgf F26G19 FAB
(Mus
musculus)		4 / 7
SER L 174
ASN L 138
ASP L 167
LYS L 169
1.60A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
GLU A 160
LEU A 156
ALA A 251
LEU A 281
1.28A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.68A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
VAL A 114
SER A 113
ASN A 151
ASP A 295
1.74A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		3e9s NSP3
(SARSr-CoV)		4 / 7
VAL A  42
ASN A  89
ASP A  38
LYS A  92
1.09A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		3e9s NSP3
(SARSr-CoV)		4 / 8
VAL A  42
ASN A  89
ASP A  38
LYS A  92
0.90A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3ea8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.66A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.64A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
CYH B 265
HIS B 246
LEU D 202
ALA D 206
LEU B 253
1.65A13.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
ASN B  96
LEU B  94
ALA B  43
LEU B  42
1.43A13.17
PO4  A 123 ( 3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLU A 290
HIS A 172
LEU A 141
ALA A 116
1.35A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH B 265
HIS B 246
LEU B 202
ALA B 206
LEU B 253
1.70A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.66A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.68A19.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH B 265
HIS B 246
LEU D 202
ALA D 206
LEU B 253
1.57A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH B 265
HIS B 246
LEU B 202
ALA B 206
LEU B 253
1.70A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLU A 290
HIS A 172
LEU A 141
ALA A 116
1.10A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.69A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
VAL A  42
ASN A  89
ASP A  38
LYS A  92
1.20A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
VAL A  42
ASN A  89
ASP A  38
LYS A  92
1.05A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		3sci SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
VAL E 337
SER E 336
ASN E 437
ASP E 480
1.76A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		3sci ACE2
(Homo
sapiens)		4 / 8
SER A 167
VAL A 132
ASN A 137
ASP A 136
1.69A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		3sci SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
VAL E 337
SER E 336
ASN E 437
ASP E 480
1.76A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3scj ACE2
(Homo
sapiens)		4 / 8
GLU A 160
LEU A 156
ALA A 251
LEU A 281
1.26A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
SER A 167
VAL A 132
ASN A 137
ASP A 136
1.58A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
GLU A 160
LEU A 156
ALA A 251
LEU A 281
1.27A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.66A19.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.67A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
VAL A  42
ASN A  89
ASP A  38
LYS A  92
1.26A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
VAL A  42
ASN A  89
ASP A  38
LYS A  92
1.09A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.67A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 7
ARG A 102
VAL A  97
ASN A 114
ASP A 121
1.64A20.85
None
OCS  A  98 ( 3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 8
ARG A 102
VAL A  97
ASN A 114
ASP A 121
1.64A20.85
None
OCS  A  98 ( 3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH B 265
HIS B 246
LEU B 202
ALA B 206
LEU B 253
1.64A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
CYH A 265
HIS A 246
LEU A 202
ALA A 206
LEU A 253
1.66A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
SER B 503
SER B 407
ASN B 408
ASP B 301
1.68A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
VAL D  42
ASN D  89
ASP D  38
LYS D  92
1.21A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
GLU A 135
ASN A  14
ALA A 150
LEU A  88
1.35A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
VAL D  42
ASN D  89
ASP D  38
LYS D  92
1.01A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_1
(HMG-COA REDUCTASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 9
SER C 503
VAL C 405
SER C 407
ASN C 408
ASP C 301
1.46A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 7
VAL C 405
SER C 407
ASN C 408
ASP C 301
1.33A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 8
SER C 503
VAL C 405
SER C 407
ASN C 408
ASP C 301
1.44A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		5x59 S PROTEIN
(MERS-CoV)		4 / 8
CYH B 736
HIS C 836
ASN C 839
LEU B 347
1.40A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5x59 S PROTEIN
(MERS-CoV)		4 / 8
SER C 643
VAL C 374
SER C 598
LYS C 381
1.68A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		5x59 S PROTEIN
(MERS-CoV)		4 / 7
VAL C 661
SER C 362
ASN A 832
LYS A 933
1.80A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
SER B 386
VAL B 496
ASN B 424
ASP B 429
1.61A16.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 7
VAL B 337
SER B 336
ASN B 437
ASP B 480
1.75A16.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 8
VAL A  42
ASN A  89
ASP A  38
LYS A  92
0.90A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
VAL A  42
ASN A  89
ASP A  38
LYS A  92
1.11A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		4 / 8
SER B 949
VAL B 945
ASN b  12
ASP b   9
1.70A11.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 9
ASN A 935
LEU a  18
ALA B 926
LEU A 927
LEU B 927
1.68A11.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		6acg ACE2
(Homo
sapiens)		5 / 9
GLU D 589
LEU D 591
ALA D 443
LEU D 440
LEU D 240
1.64A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
GLU B 755
LYS C1010
ALA C1002
LEU C1006
1.22A17.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
VAL A1104
SER A1105
ASN C 896
ASP A1109
1.41A17.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
VAL A1104
SER A1105
ASN C 896
ASP A1109
1.41A17.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ARG C 232
VAL C 102
ASN C  78
ASP C 134
1.58A17.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ARG B 977
VAL B 973
ASN B 951
ASP C 976
1.66A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
SER B 358
VAL B 354
SER B 353
LYS B 371
1.54A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6jyt HELICASE
(SARSr-CoV)		4 / 8
VAL B 452
SER B 453
ASN B 459
ASP B 458
1.69A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6jyt HELICASE
(SARSr-CoV)		4 / 7
ARG A  15
SER A  44
ASN A  46
ASP B  56
1.65A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6m17 ACE2
(Homo
sapiens)		4 / 8
SER B 167
VAL B 691
SER B 692
ASN B 159
1.67A18.71
None
None
None
NAG  B 913 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		6m1d ACE2
(Homo
sapiens)		5 / 9
ASN D 103
LEU D 100
ALA D  80
LEU D  97
LEU D  29
1.49A18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 9
CYH C 500
LEU C  85
ALA C 282
LEU C 281
LEU C 494
1.61A21.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 8
CYH C 463
LEU C 201
ALA C 202
LEU C 198
1.41A21.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6m1d ACE2
(Homo
sapiens)		4 / 8
ASN D  33
LEU D 391
ALA D  99
LEU D 100
1.27A18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
SER A 386
VAL A 496
ASN A 424
ASP A 429
1.72A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL L 168
SER L 179
ASN L 142
ASP L 172
1.37A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL H 196
ASN L 143
ASP L 172
LYS L 174
1.76A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL H 196
ASN L 143
ASP L 172
LYS L 174
1.72A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 168
SER L 179
ASN L 142
ASP L 172
1.25A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		6nur NSP12
(SARSr-CoV)		5 / 9
ASN A 312
LEU A 316
ALA A 250
LEU A 251
LEU A 186
1.54A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6nur NSP7
NSP8
(SARSr-CoV)		4 / 8
CYH D 114
ASN C  69
LEU C  60
LEU C  56
1.42A17.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6nur NSP12
NSP7
(SARSr-CoV)		4 / 8
SER C  15
VAL C  11
ASN A 416
LYS A 849
1.58A11.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6nur NSP7
(SARSr-CoV)		5 / 8
CYH C   8
HIS C  36
LEU C  40
ALA C  42
LEU C  41
1.78A11.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6nus NSP12
(SARSr-CoV)		4 / 8
ASN A 314
LEU A 351
ALA A 656
LEU A 655
1.12A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		6vw1 ACE2
(Homo
sapiens)		4 / 8
GLU B 160
LEU B 156
ALA B 251
LEU B 281
1.29A20.26
None
EDO  B 705 ( 4.9A)
None
EDO  B 705 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6vw1 ACE2
(Homo
sapiens)		4 / 8
SER A 167
VAL A 132
ASN A 137
ASP A 136
1.72A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
VAL L 163
SER L 174
ASN L 137
ASP L 167
1.32A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
VAL L 163
SER L 174
ASN L 137
ASP L 167
1.21A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
VAL L 163
SER L 174
ASN L 137
ASP L 167
1.21A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 143
ASP C 173
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 144
ASP C 173
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL B 186
ASN C 144
ASP C 173
LYS C 175
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL C 169
SER C 180
ASN C 143
ASP C 173
1.38A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL B 186
ASN C 144
ASP C 173
LYS C 175
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 144
ASP C 173
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
SER C 180
ASN C 144
ASP C 173
LYS C 175
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
SER C 180
ASN C 144
ASP C 173
LYS C 175
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 143
ASP C 173
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.60A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.38A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
SER C 180
ASN C 144
ASP C 173
LYS C 175
1.76A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL C 169
SER C 180
ASN C 144
ASP C 173
1.57A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL B 186
ASN C 144
ASP C 173
LYS C 175
1.79A17.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
SER L 180
ASN L 144
ASP L 173
LYS L 175
1.59A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
SER L 180
ASN L 144
ASP L 173
LYS L 175
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.42A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.60A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
SER L 180
ASN L 144
ASP L 173
LYS L 175
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
VAL C 169
SER C 180
ASN C 143
ASP C 173
1.37A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 143
ASP C 173
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.60A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL L 169
SER L 180
ASN L 144
ASP L 173
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 143
ASP C 173
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 144
ASP C 173
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 7
VAL C 169
SER C 180
ASN C 144
ASP C 173
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
VAL C 169
SER C 180
ASN C 144
ASP C 173
1.60A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
VAL L 169
SER L 180
ASN L 143
ASP L 173
1.38A19.10
None