Ligand ID: 06X


Drugbank ID:
DB00381
(Amlodipine)


Indication:
For the treatment of hypertension and chronic stable angina.

Get human targets for 06X in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '06X'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		1uj1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ILE B 213
PHE B 219
ILE B 281
VAL B 296
VAL B 204
1.60A23.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ILE A 281
ILE A 286
THR A 199
LEU A 272
1.18A20.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ILE A 913
ILE B 916
GLU C 918
LEU A 920
1.02A12.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE A 913
ILE B 916
GLU C 918
LEU A 920
0.93A12.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		1ysy REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 11
LEU A  19
LEU A  78
GLU A  52
PHE A  51
VAL A  18
1.79A10.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 8
ILE D  12
GLU B  15
THR A  23
LEU A  30
VAL B  10
1.72A6.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE G  13
ILE I  16
GLU K  18
LEU G  20
1.15A7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 8
ILE C  13
ILE A  16
THR E  23
LEU E  20
VAL D  22
1.71A7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 11
ILE A 335
ILE A 205
PHE A 188
ALA A 209
VAL A 218
1.56A17.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 11
ILE G 111
ILE C  73
THR G 142
VAL G 120
PRO G 121
1.55A17.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 7
ILE A  73
ILE E 112
THR A  14
LEU A  18
VAL A  21
1.56A12.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2ajf ACE2
(Homo
sapiens)		5 / 9
LEU B 370
ILE B 379
GLU B 375
PHE B 314
GLU B 406
1.62A20.77
None
None
ZN  B 901 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 8
ILE C 916
SER D1178
GLU A 918
THR A 922
LEU B 920
1.62A7.47
ACE  C 913 ( 4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 8
ILE F1161
GLU E1164
THR B 923
LEU B 930
VAL E1159
1.78A9.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE B 916
THR C 923
LEU A 920
VAL F1171
1.18A7.47
ACE  B 913 ( 3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 9
LEU G  47
LEU G  53
ILE H  20
ILE H  75
VAL G  93
1.70A10.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 9
LEU D  47
LEU D  53
ILE C  20
ILE C  75
VAL D  93
1.66A10.82
None
D10  C1099 ( 4.8A)
D10  C1099 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 9
LEU B  47
LEU B  53
ILE A  20
ILE A  75
VAL B  93
1.68A10.78
None
D10  B1099 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 11
ILE C 154
ILE C  24
PHE C   7
ALA C  28
VAL C  37
1.59A16.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 9
LEU B  18
LEU B  86
ILE B  70
GLN B  82
GLU B  89
1.60A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ILE A 281
ILE A 286
THR A 199
LEU A 272
1.16A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 11
ILE A  71
ILE A  69
ALA A  94
PRO A  67
VAL A 141
1.60A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2jzf REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 7
ILE A 549
ILE A 560
SER A 634
GLU A 535
VAL A 604
1.73A19.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2kaf NSP3
(SARSr-CoV)		5 / 9
LEU A  57
GLU A   3
PHE A  32
GLU A  49
VAL A   7
1.72A11.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
ILE D 327
ILE D 295
LEU D 331
VAL D 318
1.17A22.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
LEU C 227
ILE C 252
GLU C 210
PHE C 232
VAL C 236
1.76A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ILE A 281
ILE A 286
THR A 199
LEU A 272
1.18A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 8
ILE C  79
ILE C 107
THR C 103
LEU C  57
VAL C  84
1.75A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
ILE B 295
ILE B 235
GLU B 304
PRO B 343
VAL B 320
1.57A20.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
ILE F 143
ILE F  71
THR F 192
LEU F 189
1.15A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2w2g NSP3
(SARSr-CoV)		5 / 7
ILE B 549
ILE B 560
SER B 634
GLU B 535
VAL B 604
1.66A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2wct NSP3
(SARSr-CoV)		5 / 11
ILE D 549
PHE D 580
ILE D 556
ALA D 538
VAL D 604
1.59A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2wct NSP3
(SARSr-CoV)		5 / 9
LEU C 546
LEU C 596
ILE C 569
GLU C 587
VAL C 574
1.73A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		2wct NSP3
(SARSr-CoV)		5 / 8
ILE D 560
ILE D 549
PHE D 580
GLU D 535
LEU B 407
1.69A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ILE A 286
ILE A 281
GLU A 270
LEU A 268
1.19A20.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		3bgf F26G19 FAB
(Mus
musculus)		5 / 8
ILE B  48
PHE B  63
SER B 108
LEU B  82
VAL B 109
1.70A18.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
LEU B 370
ILE B 407
ILE B 544
PHE B 438
GLU B 406
1.58A20.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ILE A 281
ILE A 286
THR A 199
LEU A 272
1.19A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		3scj ACE2
(Homo
sapiens)		5 / 9
LEU B 370
ILE B 407
ILE B 544
PHE B 438
GLU B 406
1.60A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
LEU B 370
ILE B 407
ILE B 544
PHE B 438
GLU B 406
1.56A20.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 9
LEU A 174
LEU A 179
GLN A 175
PHE A 128
GLU A 180
1.76A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
ILE D 166
PHE D 198
THR D 113
LEU D 174
1.01A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
ILE D 166
PHE D 198
THR D 113
LEU D 174
1.05A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 9
ILE D  74
ILE D 242
GLU D  78
GLU D 204
VAL D 182
1.76A23.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		5c8u GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 10
ARG A  78
LEU A  75
MET B  57
GLU A   6
PHE B   8
1.46A13.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 10
ARG P  78
LEU P  75
MET C  57
GLU P   6
PHE C   8
1.50A12.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 8
ILE B 166
PHE B 198
THR B 113
LEU B 174
1.05A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
ILE A 136
ILE A 106
SER A 147
VAL A 114
1.48A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
SER A 301
THR A 257
LEU A 253
VAL A 297
1.74A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
ILE A 249
GLU A 240
THR A 201
LEU A 242
1.75A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
ILE A 136
ILE A 106
SER A 147
VAL A 114
1.55A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
ILE A 249
SER A 254
LEU A 227
VAL A 261
1.47A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
ILE A 136
ILE A 106
PHE A 112
GLU A 240
1.47A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		5x4r S PROTEIN
(MERS-CoV)		5 / 11
ILE A 143
ILE A 140
ILE A 120
ALA A 123
VAL A  86
1.49A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		5x4r S PROTEIN
(MERS-CoV)		4 / 8
ILE A 256
PHE A 116
GLU A 252
LEU A 180
1.32A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5x4r S PROTEIN
(MERS-CoV)		4 / 7
ILE A  56
ILE A  48
SER A 267
LEU A 251
1.12A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
ILE A 674
ILE A 650
SER A 592
LEU A 286
0.93A16.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 7
ILE A 674
ILE A 650
SER A 592
LEU A 286
0.90A16.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
ILE A 637
ILE A 610
ALA A 618
THR A 616
VAL A 581
1.65A16.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		5x5f S PROTEIN
(MERS-CoV)		5 / 11
ILE A  69
PHE A 327
PHE A  75
ILE A  56
THR A 322
1.38A16.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5x5f S PROTEIN
(MERS-CoV)		4 / 7
ILE B  56
ILE B  48
SER B 267
LEU B 251
1.15A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
LEU B 978
LEU B 959
GLN B 974
GLU B 730
VAL B 973
1.56A17.59
LEU  B 978 ( 0.6A)
LEU  B 959 ( 0.6A)
GLN  B 974 ( 0.6A)
GLU  B 730 ( 0.5A)
VAL  B 973 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
SER C 113
THR C 150
LEU C 235
VAL C 102
1.05A16.36
SER  C 113 ( 0.0A)
THR  C 150 ( 0.8A)
LEU  C 235 ( 0.5A)
VAL  C 102 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
SER C 113
THR C 150
LEU C 235
VAL C 102
1.01A16.36
SER  C 113 ( 0.0A)
THR  C 150 ( 0.8A)
LEU  C 235 ( 0.5A)
VAL  C 102 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU B 377
LEU B 504
PRO B 317
PHE B 316
VAL B 510
1.80A16.36
LEU  B 377 ( 0.6A)
LEU  B 504 ( 0.6A)
PRO  B 317 ( 1.1A)
PHE  B 316 ( 1.3A)
VAL  B 510 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5zvm SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE B 913
ILE A 916
GLU C 918
LEU B 920
1.15A10.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ILE C 913
ILE C 800
THR C 856
LEU C 788
0.97A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ILE B1097
ILE B1115
ILE B1086
ALA B1060
THR B1058
1.41A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
LEU B 927
LEU B 920
ILE B 852
GLU B 801
VAL B1042
1.54A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE B 913
ILE B 800
THR B 856
LEU B 788
1.07A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ARG C 758
ARG A1021
LEU A1006
GLU C1013
VAL C 763
1.75A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU A1045
GLU A 801
LEU A 804
PRO A 789
VAL A 860
1.67A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
LEU B 927
LEU B 920
ILE B 852
GLU B 801
VAL B1042
1.60A17.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ILE C1097
ILE C1115
ILE C1086
ALA C1060
THR C1058
1.37A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ILE B 913
ILE B 800
SER B 703
VAL B1047
1.01A16.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6cs2 ACE2
(Homo
sapiens)		5 / 9
LEU D 370
ILE D 379
GLU D 375
PHE D 314
GLU D 406
1.74A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
ILE B 913
ILE B 800
SER B 703
VAL B1047
0.96A16.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
LEU A 930
ARG B 758
GLU A 999
GLU B 755
VAL A 933
1.76A16.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
LEU A 978
LEU A 959
GLN A 974
GLU A 730
VAL A 973
1.49A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ILE A  52
GLU A 180
LEU A 168
VAL A  28
1.19A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6jyt HELICASE
(SARSr-CoV)		5 / 11
ILE B 258
ILE B 293
PHE B 262
ALA B 321
PRO B 300
1.40A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 7
ILE C 931
ILE A 934
THR C 941
LEU B 938
VAL B1189
1.55A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 8
ILE C 931
ILE A 934
THR C 941
LEU B 938
VAL B1189
1.68A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
PHE B 515
PHE B 342
ILE B 434
ALA B 363
PRO B 384
1.62A17.84
None
NAG  B 601 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6m18 ACE2
(Homo
sapiens)		5 / 9
LEU D 370
ILE D 379
GLU D 375
PHE D 314
GLU D 406
1.75A19.66
None
None
ZN  D 914 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 9
LEU A 269
ILE A  76
ILE A  72
PHE A 548
GLU A  81
1.62A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6m1d ACE2
(Homo
sapiens)		5 / 11
ILE D 618
PHE D 724
PHE D 643
ILE D 711
VAL D 700
1.59A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 8
ILE A 539
PHE A 504
THR B  93
LEU B  91
1.33A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6m71 NSP8
(SARS-CoV-2)		4 / 7
ILE B 132
GLU B 155
LEU B 169
VAL B 159
1.45A17.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 7
ILE B 185
ILE B 132
SER A 672
LEU A 389
1.36A17.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6m71 NSP7
NSP8
(SARS-CoV-2)		4 / 8
ILE C  68
SER C  57
THR C   9
LEU D 103
1.40A10.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ILE A 757
ILE A 589
THR A 686
LEU A 638
1.29A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6m71 NSP8
(SARS-CoV-2)		4 / 8
ILE B 185
ILE B 132
GLU B 155
LEU B 169
1.35A17.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6m71 NSP12
(SARS-CoV-2)		4 / 7
ILE A 171
SER A 784
GLU A 136
LEU A 142
1.37A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6m71 NSP8
(SARS-CoV-2)		4 / 7
ILE B 185
ILE B 132
GLU B 155
LEU B 169
1.33A17.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 7
ILE A 450
THR A 402
LEU A 388
VAL B 131
1.43A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6m71 NSP8
(SARS-CoV-2)		4 / 8
ILE B 132
ILE B 185
SER B 173
GLU B 171
1.24A17.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6m71 NSP12
(SARS-CoV-2)		5 / 11
ILE A 696
ILE A 589
ALA A 688
THR A 686
VAL A 637
1.56A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6m71 NSP7
NSP8
(SARS-CoV-2)		4 / 7
ILE C  68
SER C  57
THR C   9
LEU D 103
1.41A10.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ILE A 171
SER A 784
GLU A 136
LEU A 142
1.44A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6m71 NSP12
(SARS-CoV-2)		4 / 7
SER A 255
THR A 248
LEU A 316
VAL A 320
1.48A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 11
PHE A 396
ILE B 119
ALA A 399
PRO A 328
VAL A 330
1.72A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 8
ILE A 450
THR A 402
LEU A 388
VAL B 131
1.38A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6m71 NSP12
(SARS-CoV-2)		4 / 7
ILE A 757
ILE A 589
THR A 686
LEU A 638
1.26A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6m71 NSP8
(SARS-CoV-2)		4 / 7
ILE B 132
ILE B 185
SER B 173
GLU B 171
1.33A17.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 255
THR A 248
LEU A 316
VAL A 320
1.26A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 8
ILE B 185
ILE B 132
SER A 672
LEU A 389
1.40A17.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6m71 NSP8
(SARS-CoV-2)		4 / 8
ILE B 132
GLU B 155
LEU B 169
VAL B 159
1.36A17.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6m71 NSP12
NSP7
(SARS-CoV-2)		4 / 7
ILE A 548
SER C  15
LEU C  40
VAL C  11
1.46A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6m71 NSP12
(SARS-CoV-2)		5 / 11
ILE A 837
PHE A 859
ILE A 888
ALA A 840
VAL A 880
1.50A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ILE A 779
PHE A 782
SER A 768
LEU A 614
1.41A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE B 913
ILE B 800
SER B 703
VAL B1047
1.06A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ILE B 913
ILE B 800
SER B 703
VAL B1047
1.03A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ILE A 428
PHE A 334
PHE A 361
THR A 363
PRO A 493
1.58A17.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ARG C 965
LEU A 377
LEU A 532
PRO A 317
PHE A 316
1.75A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6nur NSP12
(SARSr-CoV)		4 / 8
ILE A 307
ILE A 299
PHE A 652
THR A 276
0.99A19.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6nur NSP12
NSP8
(SARSr-CoV)		5 / 11
ILE B 120
ILE B 107
ILE B 119
ALA B 110
VAL A 330
1.63A17.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6nur NSP12
(SARSr-CoV)		5 / 11
ILE A 837
PHE A 859
ILE A 888
ALA A 840
VAL A 880
1.41A20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		6nur NSP7
NSP8
(SARSr-CoV)		5 / 11
LEU C  59
ARG D  96
GLN D  88
LEU C  71
VAL C  12
1.56A10.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 8
ILE B 119
ILE B 235
GLU B 132
THR B 114
LEU B 110
1.33A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
ARG A 983
LEU C 390
LEU C 546
PRO C 330
PHE C 329
1.72A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
LEU B 390
LEU B 518
PRO B 330
PHE B 329
VAL B 524
1.74A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
LEU B 945
LEU B 938
ILE B 870
GLU B 819
VAL B1060
1.74A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
PHE B 515
PHE B 342
ILE B 434
ALA B 363
PRO B 384
1.44A16.84
None
NAG  B1315 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE C 931
ILE C 818
SER C 721
VAL C1065
1.19A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		6vw1 ACE2
(Homo
sapiens)		5 / 10
LEU B 410
LEU B 539
PRO B 415
GLU B 435
PHE B 438
1.74A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6vxs NSP3
(SARS-CoV-2)		4 / 7
GLU B 120
THR B 149
LEU B 122
VAL B  34
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6vxs NSP3
(SARS-CoV-2)		5 / 8
ILE A 106
SER A  80
GLU A 114
THR A 146
VAL A  95
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6vxs NSP3
(SARS-CoV-2)		4 / 7
GLU A 120
THR A 149
LEU A 122
VAL A  34
1.19A
None
None
None
NHE  A 202 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 8
ILE A 882
ILE A 805
PHE A 802
THR A 724
VAL A1033
1.64A17.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
LEU A 945
LEU A 938
ILE A 870
GLU A 819
VAL A1060
1.65A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
ILE A 598
ALA A 672
GLU A 654
VAL A 608
PRO A 295
1.61A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
LEU A 945
LEU A 938
ILE A 870
GLU A 819
VAL A1060
1.59A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 8
ILE C 882
ILE C 805
PHE C 802
THR C 724
VAL C1033
1.66A17.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE B  80
ILE B  97
LEU B  58
VAL B 102
1.06A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
ILE B 296
ILE B 236
GLU B 305
PRO B 344
VAL B 321
1.55A21.16
None
None
None
None
EDO  B 412 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE B  80
ILE B  97
LEU B  58
VAL B 102
1.14A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w02 NSP3
(SARS-CoV-2)		5 / 8
ILE B 106
SER B  80
GLU B 114
THR B 146
VAL B  95
1.59A15.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
ILE H  69
ILE H  20
SER H  60
GLU H  46
1.54A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
ILE H 195
SER H 188
LEU H 159
VAL H 184
1.46A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE L 117
PHE L 209
SER L 177
VAL L 146
1.22A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
ILE L 117
SER L 159
THR L 197
LEU L 136
1.79A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE L 117
SER L 159
THR L 197
LEU L 136
1.65A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
ILE H  34
ILE H  69
SER H  96
THR L  94
1.65A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
ILE C 410
SER C 399
LEU C 513
VAL C 511
1.73A15.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE L 117
PHE L 118
LEU L 175
VAL L 196
1.59A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE L  75
ILE L  21
GLU L 105
VAL L  83
1.52A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
ILE C 358
PHE C 338
SER C 383
VAL C 382
1.65A15.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE H 195
SER H 120
GLU L 123
VAL H 142
1.74A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 8
ILE H 195
SER H 188
LEU H 159
VAL H 184
1.48A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
ILE C 358
PHE C 338
THR C 393
VAL C 382
1.71A15.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE L 117
PHE L 209
SER L 159
VAL L 146
1.67A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE L 117
PHE L 209
SER L 176
THR L 180
1.76A14.04
None
None
GOL  L 301 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE H  34
ILE H  69
SER H  96
THR L  94
1.67A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
ILE L  21
GLU L  81
LEU L  47
VAL L  58
1.78A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
ILE C 410
SER C 399
LEU C 513
VAL C 511
1.70A15.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 8
ILE H  69
ILE H  20
SER H  60
GLU H  46
1.53A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE L 117
PHE L 209
THR L 178
LEU H 124
1.71A14.04
None
None
GOL  L 301 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
SER L  27
THR L  72
LEU L  33
VAL L  27
1.55A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w4h NSP16
(SARS-CoV-2)		5 / 8
ILE A7017
SER A6964
THR A6989
LEU A7004
VAL A6965
1.71A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w4h NSP16
(SARS-CoV-2)		4 / 7
ILE A6951
ILE A6969
THR A6989
VAL A6965
1.18A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ILE A6951
ILE A6866
PHE A6954
THR A6908
1.64A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 8
ILE A7017
SER A6964
THR A6989
LEU A7004
VAL A6965
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6925
THR A6891
LEU A6893
VAL A6894
1.59A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6951
ILE A6969
THR A6989
VAL A6965
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ILE A6910
PHE A6901
SER A6927
THR A6915
1.51A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6866
ILE A6955
THR A6949
VAL A6916
1.55A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A7080
ILE A7069
SER A6964
LEU A7010
1.57A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ILE A6866
PHE A6868
SER A6964
LEU A6883
1.80A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ILE A6967
ILE A6969
SER A6964
LEU A6848
1.57A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6967
ILE A6969
SER A6964
LEU A6848
1.56A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6969
ILE A7027
THR A7032
VAL A6992
1.79A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ILE A6969
ILE A7027
THR A7032
VAL A6992
1.68A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ILE A6925
PHE A6954
THR A6908
LEU A6893
1.76A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ILE A7080
ILE A7069
SER A6964
LEU A7010
1.53A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ILE A6951
ILE A6866
PHE A6954
THR A6880
1.70A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
PHE A7043
SER A6799
THR A6993
LEU A7037
1.77A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ILE A6925
ILE A6951
PHE A6868
LEU A6981
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ILE A6866
ILE A6955
THR A6949
VAL A6916
1.51A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ILE A6925
THR A6891
LEU A6893
VAL A6894
1.71A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
ILE A 136
ILE A 106
SER A 147
VAL A 114
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w6y NSP3
(SARS-CoV-2)		4 / 7
ILE A 106
SER A  80
GLU A 114
THR A 146
1.56A14.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w6y NSP3
(SARS-CoV-2)		5 / 8
ILE A 106
SER A  80
GLU A 114
THR A 146
VAL A  95
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w6y NSP3
(SARS-CoV-2)		4 / 7
GLU A 120
THR A 149
LEU A 122
VAL A  34
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w6y NSP3
(SARS-CoV-2)		4 / 8
SER B 167
THR B  13
LEU B  10
VAL B 165
1.80A14.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w6y NSP3
(SARS-CoV-2)		4 / 7
GLU B 120
THR B 149
LEU B 122
VAL B  34
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w6y NSP3
(SARS-CoV-2)		4 / 8
SER B  80
THR B 146
LEU B 127
VAL B  95
1.71A14.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w6y NSP3
(SARS-CoV-2)		4 / 7
SER A  80
GLU A 114
LEU A 127
VAL A  95
1.74A14.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w6y NSP3
(SARS-CoV-2)		4 / 7
SER A  80
GLU A 114
THR A 146
VAL A  95
1.56A14.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE C6969
ILE C7027
THR C7032
VAL C6992
1.64A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C7080
ILE C7069
SER C6964
LEU C7010
1.58A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE C6925
ILE C6955
SER C6896
VAL C6916
1.79A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE C6955
SER C6896
THR C6949
VAL C6916
1.53A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 11
ILE C6951
ILE C6969
PHE C6948
THR C6989
VAL C6965
1.71A14.78
None
None
FMT  C7115 ( 4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE A7080
ILE A7069
SER A6964
LEU A7010
1.52A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE A6969
ILE A7027
THR A7032
VAL A6992
1.61A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE A7017
THR A6989
LEU A7004
VAL A6965
1.77A14.56
FMT  A7111 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE A6925
THR A6891
LEU A6893
VAL A6894
1.70A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE A6951
ILE A6969
THR A6989
VAL A6965
1.44A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE A6969
ILE A7027
THR A7032
LEU A6825
1.77A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
PHE C7043
SER C6799
THR C6993
LEU C7037
1.66A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE C6866
PHE C6868
SER A7090
VAL A7092
1.64A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE A6925
THR A6891
LEU A6893
VAL A6894
1.58A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C6925
THR C6891
LEU C6893
VAL C6894
1.60A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C6969
ILE C7027
THR C7032
VAL C6992
1.75A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE A6925
PHE A6954
THR A6908
LEU A6893
1.78A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE A6955
SER A6896
THR A6949
VAL A6916
1.51A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE C7080
ILE C7069
SER C6964
LEU C7010
1.55A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE C6866
PHE C6954
SER C6907
VAL A7094
1.34A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE C6925
PHE C6954
THR C6908
LEU C6893
1.78A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C6955
SER C6896
THR C6949
VAL C6916
1.55A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE A6969
ILE A7027
THR A7032
VAL A6992
1.72A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE A6967
ILE A6969
SER A6964
LEU A6848
1.60A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE A7017
SER A6964
THR A6989
VAL A6965
1.65A14.56
FMT  A7111 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C6925
ILE C6955
SER C6896
VAL C6916
1.75A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE C6969
ILE C7027
THR C7032
LEU C6825
1.78A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE C7017
THR C6989
LEU C7004
VAL C6965
1.75A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE A6866
PHE A6954
SER A6907
VAL C7094
1.33A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE C7017
SER C6964
THR C6989
VAL C6965
1.62A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE A6951
ILE A6866
PHE A6954
THR A6880
1.70A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE C6967
ILE C6969
SER C6964
LEU C6848
1.60A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE C6910
PHE C6901
SER C6927
THR C6915
1.57A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE A6925
ILE A6967
SER A6896
VAL A6916
1.78A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE A6925
ILE A6955
SER A6896
VAL A6916
1.76A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE C6969
ILE C6967
PHE C6948
LEU C6848
1.65A14.56
None
None
FMT  C7115 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE C6951
ILE C6969
PHE C6948
VAL C6965
1.76A14.56
None
None
FMT  C7115 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE A6951
ILE A6866
PHE A6954
THR A6908
1.61A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C6967
ILE C6969
SER C6964
LEU C6848
1.60A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE C6925
THR C6891
LEU C6893
VAL C6894
1.71A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE A6967
ILE A6969
SER A6964
LEU A6848
1.60A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE A7080
ILE A7069
SER A6964
LEU A7010
1.55A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C6951
ILE C6969
THR C6989
VAL C6965
1.21A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ILE A6910
PHE A6901
SER A6927
THR A6915
1.55A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ILE C6951
ILE C6969
SER C6964
THR C6989
1.74A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
ILE C 276
THR C 119
LEU C 101
VAL C  98
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 8
PHE A  90
THR A 109
LEU A  -8
VAL A  -6
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wcf NSP3
(SARS-CoV-2)		4 / 7
GLU A 120
THR A 149
LEU A 122
VAL A  34
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wen NSP3
(SARS-CoV-2)		5 / 8
ILE A 106
SER A  80
GLU A 114
THR A 146
VAL A  95
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wen NSP3
(SARS-CoV-2)		4 / 7
GLU A 120
THR A 149
LEU A 122
VAL A  34
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wey NSP3
(SARS-CoV-2)		4 / 7
GLU A 324
THR A 353
LEU A 326
VAL A 238
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6wiq NSP8
(SARS-CoV-2)		5 / 11
ILE B 132
ILE B 156
PHE B 147
ALA B 188
VAL B 159
1.65A14.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6wiq NSP8
(SARS-CoV-2)		5 / 11
ILE B 120
ALA B 150
THR B 141
VAL B 130
VAL B 186
1.66A14.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 7
ILE B 107
THR A   9
LEU A  13
VAL A  16
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 7
ILE B 132
SER A  57
THR B 187
LEU B 117
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wiq NSP8
(SARS-CoV-2)		4 / 7
ILE B 132
THR B 145
LEU B 169
VAL B 159
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 8
ILE B 107
THR A   9
LEU A  13
VAL A  16
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ILE C 320
ILE D 304
PHE D 286
LEU D 339
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ILE B 320
ILE A 304
PHE A 286
LEU A 339
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ILE F 320
ILE E 304
PHE E 286
LEU E 339
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ILE E 320
ILE F 304
PHE F 286
LEU F 339
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ILE D 320
ILE C 304
PHE C 286
LEU C 339
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ILE A 320
ILE B 304
PHE B 286
LEU B 339
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ILE C6866
PHE C6954
SER C6907
VAL A7094
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
ILE C6951
ILE C6969
PHE C6948
THR C6989
VAL C6965
1.71A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ILE A6866
PHE A6954
SER A6907
VAL C7094
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE C6951
ILE C6969
THR C6989
VAL C6965
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 8
ILE C7017
SER C6964
THR C6989
LEU C7004
VAL C6965
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6951
ILE A6969
THR A6989
VAL A6965
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ILE D  84
ALA D 138
GLU D 136
VAL D  72
PRO D  73
1.77A14.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wkq NSP16
(SARS-CoV-2)		4 / 7
ILE A6951
ILE A6969
THR A6989
VAL A6965
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wkq NSP16
(SARS-CoV-2)		4 / 8
ILE A6866
PHE A6954
SER A6907
VAL C7094
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wkq NSP16
(SARS-CoV-2)		4 / 8
ILE C6866
PHE C6954
SER C6907
VAL A7094
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		5 / 11
ILE C6951
ILE C6969
PHE C6948
THR C6989
VAL C6965
1.71A21.05
None
None
FMT  C7105 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wkq NSP16
(SARS-CoV-2)		4 / 7
ILE C6951
ILE C6969
THR C6989
VAL C6965
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE A 306
SER A 329
GLU A 327
VAL A 319
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE A  80
ILE A  97
LEU A  58
VAL A 102
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
ILE A 296
ILE A 236
GLU A 305
PRO A 344
VAL A 321
1.64A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE B 108
ILE B  97
SER B 104
LEU B  58
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE A  80
ILE A  97
LEU A  58
VAL A 102
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE B 296
ILE B 236
GLU B 305
VAL B 321
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE B 108
ILE B  97
SER B 104
LEU B  58
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE A 108
ILE A  97
SER A 104
LEU A  58
1.41A
None
None
EDO  A 403 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE B 144
ILE B  72
THR B 193
LEU B 190
1.19A
None
None
EDO  B 404 (-4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
ILE B 296
ILE B 236
GLU B 305
PRO B 344
VAL B 321
1.69A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE A 323
ILE A 306
SER A 294
LEU A 251
1.48A
None
None
U5P  A 401 (-2.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE B 144
ILE B  72
THR B 193
LEU B 190
1.21A
None
None
EDO  B 404 (-4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE A 144
ILE A  72
THR A 193
LEU A 190
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE B 323
ILE B 306
PHE B 330
GLU B 211
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE A 236
ILE A 307
GLU A 211
LEU A 298
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE A 306
ILE A 323
GLU A 211
LEU A 251
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE B 306
ILE B 323
GLU B 211
LEU B 251
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE A 306
ILE A 323
GLU A 211
LEU A 251
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE A 108
ILE A  80
SER A 104
THR A  84
1.39A
None
None
EDO  A 403 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE B  80
ILE B  97
LEU B  58
VAL B 102
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE B 323
ILE B 306
SER B 294
LEU B 251
1.49A
None
None
U5P  B 401 (-2.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE A 144
ILE A  72
THR A 193
LEU A 190
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE B 323
ILE B 306
SER B 294
LEU B 251
1.44A
None
None
U5P  B 401 (-2.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE A 306
GLU A 211
LEU A 251
VAL A 237
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE B 236
ILE B 307
GLU B 211
LEU B 298
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE A 306
GLU A 211
LEU A 251
VAL A 237
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE B 306
GLU B 211
LEU B 251
VAL B 237
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE A 323
ILE A 306
SER A 294
LEU A 251
1.43A
None
None
U5P  A 401 (-2.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE B 306
GLU B 211
LEU B 251
VAL B 237
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE B 306
ILE B 323
GLU B 211
LEU B 251
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE A 328
SER A 309
THR A 193
LEU A 298
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ILE A 323
ILE A 306
PHE A 330
GLU A 211
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE A 108
ILE A  97
SER A 104
LEU A  58
1.32A
None
None
EDO  A 403 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE A 296
ILE A 236
GLU A 305
VAL A 321
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
ILE B  80
ILE B  97
LEU B  58
VAL B 102
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
ILE A 136
ILE A 106
SER A 147
VAL A 114
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
GLU C 120
THR C 149
LEU C 122
VAL C  34
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
GLU B 120
THR B 149
LEU B 122
VAL B  34
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
GLU D 120
THR D 149
LEU D 122
VAL D  34
1.26A
APR  A 201 ( 4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
GLU A 120
THR A 149
LEU A 122
VAL A  34
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
ILE A 106
SER A  80
GLU A 114
THR A 146
VAL A  95
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 8
ILE A7017
SER A6964
THR A6989
LEU A7004
VAL A6965
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ILE A6951
ILE A6969
THR A6989
VAL A6965
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wqd NSP8
(SARS-CoV-2)		4 / 7
ILE D 185
ILE D 132
GLU D 155
LEU D 169
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6wqd NSP8
(SARS-CoV-2)		5 / 11
ILE B 132
ILE B 172
ALA B 181
GLU B 171
VAL B 159
1.65A14.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wqd NSP8
(SARS-CoV-2)		4 / 7
ILE B 185
ILE B 132
GLU B 155
LEU B 169
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wqd NSP8
(SARS-CoV-2)		4 / 8
ILE B 132
GLU B 155
LEU B 169
VAL B 159
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
ILE B 107
THR A   9
LEU A  13
VAL A  16
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6wqd NSP8
(SARS-CoV-2)		5 / 11
ILE D 132
ILE D 172
ALA D 181
GLU D 171
VAL D 159
1.63A14.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wqd NSP8
(SARS-CoV-2)		4 / 8
ILE D 132
GLU D 155
LEU D 169
VAL D 159
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
ILE B 107
THR A   9
LEU A  13
VAL A  16
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wqd NSP8
(SARS-CoV-2)		4 / 7
ILE B 132
GLU B 155
LEU B 169
VAL B 159
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
ILE D 107
THR C   9
LEU C  13
VAL C  16
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
ILE D 107
THR C   9
LEU C  13
VAL C  16
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6xdc PROTEIN 3A
(SARS-CoV-2)		4 / 8
ILE B  47
SER B  58
LEU A 108
VAL A 112
1.39A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
ILE A 136
ILE A 106
PHE A 112
GLU A 240
1.49A16.35
None
None
None
DMS  A 404 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
ILE A 249
GLU A 240
THR A 201
LEU A 242
1.77A16.35
None
DMS  A 404 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
ILE A 136
ILE A 106
SER A 147
VAL A 114
1.54A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
SER A 301
THR A 257
LEU A 253
VAL A 297
1.73A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
ILE A 136
ILE A 106
SER A 147
VAL A 114
1.47A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
ILE B 185
ILE B 132
GLU B 155
LEU B 169
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
ILE D 185
ILE D 132
GLU D 155
LEU D 169
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
ILE A  39
SER A  57
THR B 123
VAL A  53
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
ILE B 132
THR B 145
LEU B 169
VAL B 159
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
ILE D 132
THR D 145
LEU D 169
VAL D 159
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
ILE B 132
GLU B 155
LEU B 169
VAL B 159
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
ILE B 132
ILE B 156
PHE B 147
ALA B 188
VAL B 159
1.76A15.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
ILE D 132
ILE D 156
PHE D 147
ALA D 188
VAL D 159
1.79A15.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
ILE D 107
THR C   9
LEU C  13
VAL C  16
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
ILE B 132
ILE B 172
ALA B 181
GLU B 171
VAL B 159
1.65A15.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
ILE B 185
ILE B 132
GLU B 155
LEU B 169
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
ILE D 185
ILE D 132
GLU D 155
LEU D 169
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
ILE B 132
GLU B 155
LEU B 169
VAL B 159
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
ILE D 132
GLU D 155
LEU D 169
VAL D 159
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
ILE B 107
THR A   9
LEU A  13
VAL A  16
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
ILE D 120
ALA D 150
THR D 141
VAL D 130
VAL D 186
1.72A15.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
ILE D 132
GLU D 155
LEU D 169
VAL D 159
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 7
ILE A  44
ILE A 106
THR A  36
VAL A  32
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 9
LEU A 513
LEU A 368
ILE B 102
PHE A 515
VAL A 382
1.78A16.81
None
None
None
None
DMS  A 905 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 10
LEU C  79
GLN C   6
LEU C  39
PRO C  50
VAL C  91
1.76A17.63
None
None
None
None
1PE  C 301 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 10
LEU L  79
GLN L   6
LEU L  39
PRO L  50
VAL L  91
1.79A17.63
None
None
None
None
1PE  L1603 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 8
ILE B  93
GLU B  10
THR B   9
VAL B 117
1.43A
None
None
MLI  B 304 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
ILE H 199
SER H 192
LEU H 163
VAL H 188
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
ILE B 199
SER B 192
LEU B 163
VAL B 188
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 8
ILE H  93
GLU H  10
THR H   9
VAL H 117
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
ILE C 123
PHE C 215
SER C 183
VAL C 152
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
ILE C  81
PHE C  68
GLU C 111
LEU C  11
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 8
ILE H 199
SER H 192
LEU H 163
VAL H 188
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 8
ILE B 199
SER B 192
LEU B 163
VAL B 188
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
ILE L 123
PHE L 215
SER L 183
VAL L 152
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 9
LEU E 513
LEU E 368
ILE H 102
PHE E 515
VAL E 382
1.80A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 8
ILE H  93
GLU H  10
THR H   9
VAL H 117
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
ILE H 199
SER H 192
LEU H 163
VAL H 188
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 8
ILE H 199
SER H 192
LEU H 163
VAL H 188
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
ILE L 123
PHE L 215
SER L 183
VAL L 152
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 10
LEU L  79
GLN L   6
LEU L  39
PRO L  50
VAL L  91
1.75A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
ILE A 136
ILE A 106
SER A 147
VAL A 114
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 8
ILE B 199
SER B 192
LEU B 163
VAL B 188
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 8
ILE B  93
GLU B  10
THR B   9
VAL B 117
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
ILE C 123
PHE C 215
SER C 183
VAL C 152
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
ILE H 199
SER H 192
LEU H 163
VAL H 188
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
ILE L 123
PHE L 215
SER L 183
VAL L 152
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
ILE B 199
SER B 192
LEU B 163
VAL B 188
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 10
LEU L  79
GLN L   6
LEU L  39
PRO L  50
VAL L  91
1.79A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 8
ILE H 199
SER H 192
LEU H 163
VAL H 188
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 8
ILE H  93
GLU H  10
THR H   9
VAL H 117
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU E 120
THR E 149
LEU E 122
VAL E  34
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
ILE C 106
SER C  80
GLU C 114
THR C 146
VAL C  95
1.69A
EDO  C 208 ( 4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU B 120
THR B 149
LEU B 122
VAL B  34
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
ILE B 106
SER B  80
GLU B 114
THR B 146
VAL B  95
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU A 120
THR A 149
LEU A 122
VAL A  34
1.15A
None
EDO  A 203 ( 4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
ILE E 106
SER E  80
GLU E 114
THR E 146
VAL E  95
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU D 120
THR D 149
LEU D 122
VAL D  34
1.12A
None
EDO  D 203 ( 4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU C 120
THR C 149
LEU C 122
VAL C  34
1.17A
 MG  C 201 ( 1.7A)
EDO  C 206 ( 4.9A)
None
EDO  C 207 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU A 120
THR A 149
LEU A 122
VAL A  34
1.08A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
ILE E 106
SER E  80
GLU E 114
THR E 146
VAL E  95
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU B 120
THR B 149
LEU B 122
VAL B  34
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU C 120
THR C 149
LEU C 122
VAL C  34
1.16A
 MG  C 202 (-1.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
ILE B 106
SER B  80
GLU B 114
THR B 146
VAL B  95
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU E 120
THR E 149
LEU E 122
VAL E  34
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU D 120
THR D 149
LEU D 122
VAL D  34
1.11A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
ILE C 106
SER C  80
GLU C 114
THR C 146
VAL C  95
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU C 120
THR C 149
LEU C 122
VAL C  34
1.17A
EDO  C 204 (-4.9A)
EDO  C 204 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU B 120
THR B 149
LEU B 122
VAL B  34
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
GLU A 120
THR A 149
LEU A 122
VAL A  34
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7btf NSP12
(SARS-CoV-2)		4 / 7
ILE A 696
THR A 686
LEU A 638
VAL A 637
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7btf NSP8
(SARS-CoV-2)		4 / 8
ILE D 132
ILE D 156
SER D 177
GLU D 171
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7btf NSP12
(SARS-CoV-2)		4 / 7
ILE A 171
SER A 784
GLU A 136
LEU A 142
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 9
LEU B  95
ILE B 107
ILE B 120
PHE A 340
VAL A 341
1.47A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7btf NSP12
NSP7
(SARS-CoV-2)		4 / 7
ILE A 548
SER C  15
LEU C  40
VAL C  11
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 255
THR A 248
LEU A 316
VAL A 320
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7btf NSP8
(SARS-CoV-2)		5 / 8
ILE B 132
GLU B 155
THR B 145
LEU B 169
VAL B 159
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		7btf NSP12
(SARS-CoV-2)		5 / 11
ILE A 696
ILE A 589
ALA A 688
THR A 686
VAL A 637
1.51A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 11
PHE A 396
ILE B 119
ALA A 399
PRO A 328
VAL A 330
1.71A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7btf NSP12
(SARS-CoV-2)		4 / 8
ILE A 757
ILE A 589
THR A 686
LEU A 638
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 7
ILE D 132
SER C  57
THR D 187
LEU D 117
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7btf NSP12
(SARS-CoV-2)		4 / 8
ILE A 589
THR A 687
LEU A 638
VAL A 637
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		7btf NSP12
(SARS-CoV-2)		5 / 11
ILE A 837
PHE A 859
ILE A 888
ALA A 840
VAL A 880
1.47A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 8
ILE A 450
THR A 402
LEU A 388
VAL B 131
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7btf NSP8
(SARS-CoV-2)		4 / 7
ILE D 132
ILE D 156
SER D 177
GLU D 171
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 7
ILE A 450
THR A 402
LEU A 388
VAL B 131
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		7btf NSP8
(SARS-CoV-2)		5 / 11
ILE D 120
ALA D 150
THR D 148
VAL D 130
VAL D 186
1.80A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7btf NSP12
(SARS-CoV-2)		4 / 7
ILE A 757
ILE A 589
THR A 686
LEU A 638
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7btf NSP8
(SARS-CoV-2)		4 / 7
ILE B 132
THR B 146
LEU B 169
VAL B 159
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7btf NSP12
(SARS-CoV-2)		4 / 8
ILE A 779
PHE A 782
SER A 768
LEU A 614
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7btf NSP8
(SARS-CoV-2)		4 / 7
ILE B 132
THR B 145
LEU B 169
VAL B 159
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7btf NSP12
(SARS-CoV-2)		4 / 8
ILE A 171
SER A 784
GLU A 136
LEU A 142
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7btf NSP12
NSP7
(SARS-CoV-2)		4 / 7
ILE A 548
SER C   4
GLU A 436
LEU A 838
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7bv1 NSP8
(SARS-CoV-2)		4 / 7
ILE B 132
THR B 145
LEU B 169
VAL B 159
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
SER A 255
THR A 248
LEU A 316
VAL A 320
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 11
PHE A 396
ILE B 119
ALA A 399
PRO A 328
VAL A 330
1.70A18.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7bv1 NSP8
(SARS-CoV-2)		4 / 8
ILE B 132
THR B 145
LEU B 169
VAL B 159
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
ILE A 696
ILE A 589
ALA A 688
THR A 686
VAL A 637
1.42A18.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ILE A 757
ILE A 589
THR A 686
LEU A 638
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 8
ILE C  39
SER C  57
THR D 123
VAL C  53
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ILE A 779
PHE A 782
SER A 768
LEU A 614
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 7
ILE D 107
THR C   9
LEU C  13
VAL C  16
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 7
ILE B 185
ILE B 132
SER A 672
LEU A 389
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
ILE A 171
SER A 784
GLU A 136
LEU A 142
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ILE A 171
SER A 784
GLU A 136
LEU A 142
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
ILE A 757
ILE A 589
THR A 686
LEU A 638
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
ILE A 837
PHE A 859
ILE A 888
ALA A 840
VAL A 880
1.53A18.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 8
ILE B 185
ILE B 132
SER A 672
LEU A 389
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
ILE A 696
ILE A 589
ALA A 688
THR A 686
VAL A 637
1.52A18.92
None
None
F86  P 102 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7bv2 NSP8
(SARS-CoV-2)		5 / 7
ILE B 132
GLU B 155
THR B 145
LEU B 169
VAL B 159
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7bv2 NSP8
(SARS-CoV-2)		4 / 8
ILE B 132
ILE B 185
SER B 173
GLU B 171
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7bv2 NSP8
(SARS-CoV-2)		5 / 8
ILE B 132
GLU B 155
THR B 146
LEU B 169
VAL B 159
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
ILE A 171
SER A 784
GLU A 136
LEU A 142
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
ILE A 837
PHE A 859
ILE A 888
ALA A 840
VAL A 880
1.48A18.92
None
None
None
U  P  18 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7bv2 NSP8
(SARS-CoV-2)		5 / 8
ILE B 132
GLU B 155
THR B 145
LEU B 169
VAL B 159
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 11
PHE A 396
ILE B 119
ALA A 399
PRO A 328
VAL A 330
1.69A18.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 8
ILE A 539
PHE A 504
THR B  93
LEU B  91
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
SER A 255
THR A 248
LEU A 316
VAL A 320
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 255
THR A 248
LEU A 316
VAL A 320
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 8
ILE A 450
THR A 402
LEU A 388
VAL B 131
1.34A
None