Ligand ID: 06X


Drugbank ID:
DB00381
(Amlodipine)


Indication:
For the treatment of hypertension and chronic stable angina.

Get human targets for 06X in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '06X' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		1uj1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ILE B 213
PHE B 219
ILE B 281
VAL B 296
VAL B 204
1.60A23.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ILE A 281
ILE A 286
THR A 199
LEU A 272
1.18A20.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ILE A 913
ILE B 916
GLU C 918
LEU A 920
1.02A12.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE A 913
ILE B 916
GLU C 918
LEU A 920
0.93A12.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		1ysy REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 11
LEU A  19
LEU A  78
GLU A  52
PHE A  51
VAL A  18
1.79A10.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 8
ILE D  12
GLU B  15
THR A  23
LEU A  30
VAL B  10
1.72A6.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE G  13
ILE I  16
GLU K  18
LEU G  20
1.15A7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 8
ILE C  13
ILE A  16
THR E  23
LEU E  20
VAL D  22
1.71A7.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 11
ILE A 335
ILE A 205
PHE A 188
ALA A 209
VAL A 218
1.56A17.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 11
ILE G 111
ILE C  73
THR G 142
VAL G 120
PRO G 121
1.55A17.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 7
ILE A  73
ILE E 112
THR A  14
LEU A  18
VAL A  21
1.56A12.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2ajf ACE2
(Homo
sapiens)		5 / 9
LEU B 370
ILE B 379
GLU B 375
PHE B 314
GLU B 406
1.62A20.77
None
None
ZN  B 901 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 8
ILE C 916
SER D1178
GLU A 918
THR A 922
LEU B 920
1.62A7.47
ACE  C 913 ( 4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 8
ILE F1161
GLU E1164
THR B 923
LEU B 930
VAL E1159
1.78A9.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE B 916
THR C 923
LEU A 920
VAL F1171
1.18A7.47
ACE  B 913 ( 3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 9
LEU G  47
LEU G  53
ILE H  20
ILE H  75
VAL G  93
1.70A10.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 9
LEU D  47
LEU D  53
ILE C  20
ILE C  75
VAL D  93
1.66A10.82
None
D10  C1099 ( 4.8A)
D10  C1099 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 9
LEU B  47
LEU B  53
ILE A  20
ILE A  75
VAL B  93
1.68A10.78
None
D10  B1099 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 11
ILE C 154
ILE C  24
PHE C   7
ALA C  28
VAL C  37
1.59A16.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 9
LEU B  18
LEU B  86
ILE B  70
GLN B  82
GLU B  89
1.60A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ILE A 281
ILE A 286
THR A 199
LEU A 272
1.16A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 11
ILE A  71
ILE A  69
ALA A  94
PRO A  67
VAL A 141
1.60A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2jzf REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 7
ILE A 549
ILE A 560
SER A 634
GLU A 535
VAL A 604
1.73A19.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2kaf NSP3
(SARSr-CoV)		5 / 9
LEU A  57
GLU A   3
PHE A  32
GLU A  49
VAL A   7
1.72A11.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
ILE D 327
ILE D 295
LEU D 331
VAL D 318
1.17A22.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
LEU C 227
ILE C 252
GLU C 210
PHE C 232
VAL C 236
1.76A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ILE A 281
ILE A 286
THR A 199
LEU A 272
1.18A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 8
ILE C  79
ILE C 107
THR C 103
LEU C  57
VAL C  84
1.75A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
ILE B 295
ILE B 235
GLU B 304
PRO B 343
VAL B 320
1.57A20.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
ILE F 143
ILE F  71
THR F 192
LEU F 189
1.15A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		2w2g NSP3
(SARSr-CoV)		5 / 7
ILE B 549
ILE B 560
SER B 634
GLU B 535
VAL B 604
1.66A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		2wct NSP3
(SARSr-CoV)		5 / 11
ILE D 549
PHE D 580
ILE D 556
ALA D 538
VAL D 604
1.59A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		2wct NSP3
(SARSr-CoV)		5 / 9
LEU C 546
LEU C 596
ILE C 569
GLU C 587
VAL C 574
1.73A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		2wct NSP3
(SARSr-CoV)		5 / 8
ILE D 560
ILE D 549
PHE D 580
GLU D 535
LEU B 407
1.69A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ILE A 286
ILE A 281
GLU A 270
LEU A 268
1.19A20.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		3bgf F26G19 FAB
(Mus
musculus)		5 / 8
ILE B  48
PHE B  63
SER B 108
LEU B  82
VAL B 109
1.70A18.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
LEU B 370
ILE B 407
ILE B 544
PHE B 438
GLU B 406
1.58A20.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ILE A 281
ILE A 286
THR A 199
LEU A 272
1.19A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		3scj ACE2
(Homo
sapiens)		5 / 9
LEU B 370
ILE B 407
ILE B 544
PHE B 438
GLU B 406
1.60A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
LEU B 370
ILE B 407
ILE B 544
PHE B 438
GLU B 406
1.56A20.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 9
LEU A 174
LEU A 179
GLN A 175
PHE A 128
GLU A 180
1.76A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
ILE D 166
PHE D 198
THR D 113
LEU D 174
1.01A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
ILE D 166
PHE D 198
THR D 113
LEU D 174
1.05A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 9
ILE D  74
ILE D 242
GLU D  78
GLU D 204
VAL D 182
1.76A23.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		5c8u GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 10
ARG A  78
LEU A  75
MET B  57
GLU A   6
PHE B   8
1.46A13.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 10
ARG P  78
LEU P  75
MET C  57
GLU P   6
PHE C   8
1.50A12.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 8
ILE B 166
PHE B 198
THR B 113
LEU B 174
1.05A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		5x4r S PROTEIN
(MERS-CoV)		5 / 11
ILE A 143
ILE A 140
ILE A 120
ALA A 123
VAL A  86
1.49A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		5x4r S PROTEIN
(MERS-CoV)		4 / 8
ILE A 256
PHE A 116
GLU A 252
LEU A 180
1.32A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5x4r S PROTEIN
(MERS-CoV)		4 / 7
ILE A  56
ILE A  48
SER A 267
LEU A 251
1.12A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
ILE A 674
ILE A 650
SER A 592
LEU A 286
0.93A16.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 7
ILE A 674
ILE A 650
SER A 592
LEU A 286
0.90A16.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
ILE A 637
ILE A 610
ALA A 618
THR A 616
VAL A 581
1.65A16.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		5x5f S PROTEIN
(MERS-CoV)		5 / 11
ILE A  69
PHE A 327
PHE A  75
ILE A  56
THR A 322
1.38A16.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5x5f S PROTEIN
(MERS-CoV)		4 / 7
ILE B  56
ILE B  48
SER B 267
LEU B 251
1.15A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
LEU B 978
LEU B 959
GLN B 974
GLU B 730
VAL B 973
1.56A17.59
LEU  B 978 ( 0.6A)
LEU  B 959 ( 0.6A)
GLN  B 974 ( 0.6A)
GLU  B 730 ( 0.5A)
VAL  B 973 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
SER C 113
THR C 150
LEU C 235
VAL C 102
1.05A16.36
SER  C 113 ( 0.0A)
THR  C 150 ( 0.8A)
LEU  C 235 ( 0.5A)
VAL  C 102 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
SER C 113
THR C 150
LEU C 235
VAL C 102
1.01A16.36
SER  C 113 ( 0.0A)
THR  C 150 ( 0.8A)
LEU  C 235 ( 0.5A)
VAL  C 102 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU B 377
LEU B 504
PRO B 317
PHE B 316
VAL B 510
1.80A16.36
LEU  B 377 ( 0.6A)
LEU  B 504 ( 0.6A)
PRO  B 317 ( 1.1A)
PHE  B 316 ( 1.3A)
VAL  B 510 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		5zvm SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE B 913
ILE A 916
GLU C 918
LEU B 920
1.15A10.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ILE C 913
ILE C 800
THR C 856
LEU C 788
0.97A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ILE B1097
ILE B1115
ILE B1086
ALA B1060
THR B1058
1.41A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
LEU B 927
LEU B 920
ILE B 852
GLU B 801
VAL B1042
1.54A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE B 913
ILE B 800
THR B 856
LEU B 788
1.07A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ARG C 758
ARG A1021
LEU A1006
GLU C1013
VAL C 763
1.75A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
LEU A1045
GLU A 801
LEU A 804
PRO A 789
VAL A 860
1.67A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
LEU B 927
LEU B 920
ILE B 852
GLU B 801
VAL B1042
1.60A17.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ILE C1097
ILE C1115
ILE C1086
ALA C1060
THR C1058
1.37A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ILE B 913
ILE B 800
SER B 703
VAL B1047
1.01A16.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6cs2 ACE2
(Homo
sapiens)		5 / 9
LEU D 370
ILE D 379
GLU D 375
PHE D 314
GLU D 406
1.74A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
ILE B 913
ILE B 800
SER B 703
VAL B1047
0.96A16.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
LEU A 930
ARG B 758
GLU A 999
GLU B 755
VAL A 933
1.76A16.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
LEU A 978
LEU A 959
GLN A 974
GLU A 730
VAL A 973
1.49A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ILE A  52
GLU A 180
LEU A 168
VAL A  28
1.19A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6jyt HELICASE
(SARSr-CoV)		5 / 11
ILE B 258
ILE B 293
PHE B 262
ALA B 321
PRO B 300
1.40A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6m18 ACE2
(Homo
sapiens)		5 / 9
LEU D 370
ILE D 379
GLU D 375
PHE D 314
GLU D 406
1.75A19.66
None
None
ZN  D 914 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 9
LEU A 269
ILE A  76
ILE A  72
PHE A 548
GLU A  81
1.62A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6m1d ACE2
(Homo
sapiens)		5 / 11
ILE D 618
PHE D 724
PHE D 643
ILE D 711
VAL D 700
1.59A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE B 913
ILE B 800
SER B 703
VAL B1047
1.06A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ILE B 913
ILE B 800
SER B 703
VAL B1047
1.03A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ILE A 428
PHE A 334
PHE A 361
THR A 363
PRO A 493
1.58A17.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ARG C 965
LEU A 377
LEU A 532
PRO A 317
PHE A 316
1.75A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6nur NSP12
(SARSr-CoV)		4 / 8
ILE A 307
ILE A 299
PHE A 652
THR A 276
0.99A19.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6nur NSP12
NSP8
(SARSr-CoV)		5 / 11
ILE B 120
ILE B 107
ILE B 119
ALA B 110
VAL A 330
1.63A17.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		6nur NSP12
(SARSr-CoV)		5 / 11
ILE A 837
PHE A 859
ILE A 888
ALA A 840
VAL A 880
1.41A20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		6nur NSP7
NSP8
(SARSr-CoV)		5 / 11
LEU C  59
ARG D  96
GLN D  88
LEU C  71
VAL C  12
1.56A10.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		6vw1 ACE2
(Homo
sapiens)		5 / 10
LEU B 410
LEU B 539
PRO B 415
GLU B 435
PHE B 438
1.74A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
ILE H  69
ILE H  20
SER H  60
GLU H  46
1.54A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
ILE H 195
SER H 188
LEU H 159
VAL H 184
1.46A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE L 117
PHE L 209
SER L 177
VAL L 146
1.22A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
ILE L 117
SER L 159
THR L 197
LEU L 136
1.79A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE L 117
SER L 159
THR L 197
LEU L 136
1.65A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
ILE H  34
ILE H  69
SER H  96
THR L  94
1.65A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE L 117
PHE L 118
LEU L 175
VAL L 196
1.59A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE L  75
ILE L  21
GLU L 105
VAL L  83
1.52A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE H 195
SER H 120
GLU L 123
VAL H 142
1.74A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 8
ILE H 195
SER H 188
LEU H 159
VAL H 184
1.48A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE L 117
PHE L 209
SER L 159
VAL L 146
1.67A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE L 117
PHE L 209
SER L 176
THR L 180
1.76A14.04
None
None
GOL  L 301 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE H  34
ILE H  69
SER H  96
THR L  94
1.67A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
ILE L  21
GLU L  81
LEU L  47
VAL L  58
1.78A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 8
ILE H  69
ILE H  20
SER H  60
GLU H  46
1.53A16.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ILE L 117
PHE L 209
THR L 178
LEU H 124
1.71A14.04
None
None
GOL  L 301 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
SER L  27
THR L  72
LEU L  33
VAL L  27
1.55A14.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 10
LEU C  79
GLN C   6
LEU C  39
PRO C  50
VAL C  91
1.76A17.63
None
None
None
None
1PE  C 301 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 10
LEU L  79
GLN L   6
LEU L  39
PRO L  50
VAL L  91
1.79A17.63
None
None
None
None
1PE  L1603 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 8
ILE B  93
GLU B  10
THR B   9
VAL B 117
1.43A
None
None
MLI  B 304 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
ILE H 199
SER H 192
LEU H 163
VAL H 188
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
ILE B 199
SER B 192
LEU B 163
VAL B 188
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 8
ILE H  93
GLU H  10
THR H   9
VAL H 117
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
ILE C 123
PHE C 215
SER C 183
VAL C 152
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
ILE C  81
PHE C  68
GLU C 111
LEU C  11
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 8
ILE H 199
SER H 192
LEU H 163
VAL H 188
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 8
ILE B 199
SER B 192
LEU B 163
VAL B 188
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
ILE L 123
PHE L 215
SER L 183
VAL L 152
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 8
ILE H  93
GLU H  10
THR H   9
VAL H 117
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
ILE H 199
SER H 192
LEU H 163
VAL H 188
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 8
ILE H 199
SER H 192
LEU H 163
VAL H 188
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
ILE L 123
PHE L 215
SER L 183
VAL L 152
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 10
LEU L  79
GLN L   6
LEU L  39
PRO L  50
VAL L  91
1.75A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 8
ILE B 199
SER B 192
LEU B 163
VAL B 188
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 8
ILE B  93
GLU B  10
THR B   9
VAL B 117
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
ILE C 123
PHE C 215
SER C 183
VAL C 152
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
ILE H 199
SER H 192
LEU H 163
VAL H 188
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
ILE L 123
PHE L 215
SER L 183
VAL L 152
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
ILE B 199
SER B 192
LEU B 163
VAL B 188
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 10
LEU L  79
GLN L   6
LEU L  39
PRO L  50
VAL L  91
1.79A17.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 8
ILE H 199
SER H 192
LEU H 163
VAL H 188
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 8
ILE H  93
GLU H  10
THR H   9
VAL H 117
1.31A
None