HEADER STRUCTURAL GENOMICS, UNKNOWN FUNCTION 20-DEC-05 2FFS COMPND HYPOTHETICAL PROTEIN PA1206; COMPND 3 CHAIN: A, B; COMPND 4 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: PSEUDOMONAS AERUGINOSA; SOURCE 3 ORGANISM_TAXID: 208964; SOURCE 4 STRAIN: PAO1; SOURCE 5 GENE: PA1206; SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); SOURCE 7 EXPRESSION_SYSTEM_TAXID: 469008; SOURCE 8 EXPRESSION_SYSTEM_STRAIN: BL21(DE3); SOURCE 9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; SOURCE 10 EXPRESSION_SYSTEM_PLASMID: PET15B (MODIFIED) AUTHOR M.D.ZIMMERMAN,M.CHRUSZCZ,M.T.CYMBOROWSKI,S.WANG,O.KIRILLOVA, AUTHOR 2 T.SKARINA,O.ONOPRIYENKO,A.SAVCHENKO,A.EDWARDS,A.JOACHIMIAK,W.MINOR, AUTHOR 3 MIDWEST CENTER FOR STRUCTURAL GENOMICS (MCSG) HET MSE A 1 16 HET MSE A 96 8 HET MSE A 137 8 HET MSE B 1 8 HET MSE B 96 8 HET MSE B 137 8 mMETA 1 83.32 63.08 30.03 82.85 63.20 29.16 84.78 61.56 31.36 85.13 60.99 30.32 84.01 62.90 31.34 83.01 63.08 32.53 2 0 1000.00-999 ?-999 ?-999 ? mGLN.A 2 85.04 61.12 32.59 84.72 61.80 33.24 84.74 58.69 33.38 83.70 58.87 34.01 85.68 59.87 33.05 86.62 60.15 34.24 2 0 1000.00-999 ?-999 ?-999 ? mPHE^A 3 85.11 57.50 32.93 85.89 57.52 32.30 85.46 55.39 33.95 86.56 55.24 33.41 84.44 56.27 33.33 83.88 55.58 32.11 3 0 1000.00-999 ?-999 ?-999 ? mGLU^A 4 85.13 54.79 35.07 84.21 54.98 35.42 85.38 52.61 36.01 84.17 52.62 36.22 86.08 53.91 35.71 86.68 54.56 36.98 2 0 1000.00-999 ?-999 ?-999 ? mHIS^A 5 86.13 51.50 36.02 87.11 51.66 35.93 86.58 49.23 36.72 87.74 49.21 36.28 85.55 50.17 36.15 85.13 49.69 34.78 3 0 1000.00-999 ?-999 ?-999 ? mLEU^A 6 86.20 48.47 37.74 85.22 48.50 37.93 86.93 46.23 38.19 85.84 45.79 38.37 87.18 47.68 38.48 86.98 47.97 39.95 3 0 1000.00-999 ?-999 ?-999 ? mVAL^A 7 87.90 45.49 37.69 88.77 45.96 37.52 88.39 43.26 38.45 89.59 43.46 38.67 87.67 44.08 37.42 88.20 43.66 36.06 3 0 1000.00-999 ?-999 ?-999 ? mGLN^A 8 87.68 42.34 39.09 86.71 42.33 38.85 89.05 40.32 39.32 88.49 39.65 38.47 88.29 41.43 40.05 87.25 40.84 41.00 2 0 1000.00-999 ?-999 ?-999 ? mVAL.A 9 90.31 40.11 39.68 90.61 40.63 40.48 91.00 37.68 39.27 90.88 36.84 38.37 91.15 39.18 38.92 92.65 39.61 38.91 3 0 1000.00-999 ?-999 ?-999 ? mASN.A 10 91.07 37.35 40.56 91.22 38.13 41.16 89.61 35.74 41.82 89.09 36.68 42.44 90.92 35.96 41.04 92.06 35.63 42.01 2 0 1000.00-999 ?-999 ?-999 ? mASP.A 11 89.11 34.50 41.85 89.70 33.83 41.40 87.88 32.78 43.23 88.94 32.14 43.28 87.81 34.16 42.50 86.65 34.21 41.49 2 0 1000.00-999 ?-999 ?-999 ? mARG.A 12 86.75 32.37 43.82 86.02 33.05 43.83 85.85 30.15 43.35 84.67 30.43 43.03 86.60 31.03 44.39 85.79 31.11 45.70 2 0 1000.00-999 ?-999 ?-999 ? mTHR.A 13 86.51 29.14 42.76 87.46 29.05 43.07 86.60 26.92 41.59 87.59 26.80 40.82 85.88 28.27 41.73 85.82 28.91 40.29 2 0 1000.00-999 ?-999 ?-999 ? mLEU.A 17 89.05 27.72 36.86 88.54 26.93 37.22 91.19 29.12 37.04 91.35 28.86 38.26 89.79 28.86 36.34 88.85 30.11 36.28 3 0 1000.00-999 ?-999 ?-999 ? mPRO.A 18 92.20 29.60 36.28 91.92 29.78 35.33 93.69 31.01 37.73 93.10 32.06 37.47 93.59 29.84 36.74 94.31 30.27 35.44 3 0 1000.00-999 ?-999 ?-999 ? mVAL.A 19 94.45 30.84 38.81 94.78 29.90 38.93 96.06 32.64 39.27 96.88 32.04 38.57 94.77 31.93 39.74 94.86 31.43 41.22 3 0 1000.00-999 ?-999 ?-999 ? mLEU.A 20 96.23 33.91 39.63 95.51 34.26 40.24 98.00 35.45 40.38 97.32 35.84 41.32 97.34 34.74 39.19 96.84 35.79 38.21 3 0 1000.00-999 ?-999 ?-999 ? mASP~A 21 99.31 35.63 40.32 99.76 35.19 39.55 100.24 37.83 40.71 99.97 38.05 39.50 100.00 36.42 41.33 101.28 35.72 41.78 2 0 1000.00-999 ?-999 ?-999 ? mARG~A 22 100.76 38.75 41.52 101.06 38.40 42.41 101.78 40.31 39.92 101.50 41.06 38.97 100.89 40.15 41.14 101.48 40.94 42.31 2 0 1000.00-999 ?-999 ?-999 ? mLEU~A 23 102.87 39.58 39.93 102.98 38.94 40.70 103.28 39.13 37.52 103.50 39.71 36.40 103.81 39.76 38.86 105.16 39.27 39.32 3 0 1000.00-999 ?-999 ?-999 ? mGLN~A 24 102.56 38.01 37.62 102.47 37.62 38.54 100.97 38.41 35.80 100.96 38.62 34.57 101.97 37.42 36.40 101.28 36.10 36.65 2 0 1000.00-999 ?-999 ?-999 ? mLEU~A 25 100.15 39.05 36.64 100.27 38.83 37.61 99.86 41.24 35.50 99.49 41.71 34.43 99.17 40.01 36.11 98.19 40.42 37.19 3 0 1000.00-999 ?-999 ?-999 ? mTRP~A 26 100.89 41.73 36.17 100.99 41.38 37.10 102.27 42.17 34.22 102.12 42.84 33.26 101.78 42.70 35.56 102.97 43.06 36.48 3 0 1000.00-999 ?-999 ?-999 ? mGLU~A 27 102.83 40.97 34.13 102.88 40.45 34.98 102.18 40.60 31.78 102.38 41.02 30.61 103.31 40.54 32.81 103.99 39.15 32.85 2 0 1000.00-999 ?-999 ?-999 ? mGLY~A 28 100.97 40.27 32.24 100.96 39.93 33.18 99.58 41.79 30.84 99.33 41.94 29.63 99.77 40.40 31.41-999.99-999.99-999.99 1 0 1000.00-999 ?-999 ?-999 ? mLEU~A 29 99.71 42.82 31.68 99.95 42.58 32.62 100.64 44.59 30.22 100.37 45.33 29.23 99.51 44.18 31.19 99.47 45.15 32.35 3 0 1000.00-999 ?-999 ?-999 ? mVAL~A 30 101.89 44.14 30.46 102.01 43.60 31.30 102.61 43.79 28.20 102.75 44.37 27.11 102.95 44.45 29.53 104.33 43.85 29.98 3 0 1000.00-999 ?-999 ?-999 ? mCYH~A 31 102.18 42.54 28.29 102.16 42.18 29.22 100.74 42.53 26.32 100.87 42.57 25.09 101.78 41.79 27.15 101.25 40.42 27.55 2 0 1000.00-999 ?-999 ?-999 ? mARG~A 32 99.71 43.10 26.98 99.69 42.98 27.97 99.33 45.04 25.53 98.85 45.42 24.49 98.73 43.85 26.24 97.55 44.36 27.10 2 0 1000.00-999 ?-999 ?-999 ? mALA~A 33 100.36 45.65 26.09 100.65 45.25 26.96 101.85 46.44 24.29 101.77 47.11 23.26 101.00 46.81 25.45 101.81 47.58 26.40 2 0 1000.00-999 ?-999 ?-999 ? mARG~A 34 102.66 45.38 24.42 102.53 44.88 25.27 103.12 43.96 22.41 103.73 43.75 21.34 103.63 45.00 23.40 104.89 44.46 24.09 2 0 1000.00-999 ?-999 ?-999 ? mGLU~A 35 102.06 43.24 22.76 101.65 43.46 23.64 100.04 42.31 21.70 99.28 41.38 22.05 101.56 42.20 21.87 102.00 40.82 22.36 2 0 1000.00-999 ?-999 ?-999 ? mPRO~A 36 99.57 43.43 21.08 100.27 44.01 20.66 97.34 42.73 20.18 96.11 42.64 20.29 98.14 43.72 21.05 98.09 45.12 20.44 3 0 1000.00-999 ?-999 ?-999 ? mGLN~A 37 98.02 41.95 19.37 99.01 42.10 19.35 96.59 39.90 19.46 95.69 39.23 19.00 97.29 40.95 18.58 98.17 40.29 17.49 2 0 1000.00-999 ?-999 ?-999 ? mTYR~A 38 96.98 39.76 20.74 97.74 40.34 21.03 95.02 39.36 22.23 94.19 38.62 22.77 96.27 38.78 21.58 97.19 38.18 22.63 3 0 1000.00-999 ?-999 ?-999 ? mPHE~A 39 94.86 40.67 22.15 95.54 41.13 21.58 92.84 42.15 21.93 91.80 42.60 22.38 93.78 41.37 22.86 94.40 42.40 23.82 3 0 1000.00-999 ?-999 ?-999 ? mVAL.A 40 93.23 42.42 20.69 94.00 41.90 20.31 91.78 42.76 18.95 92.39 42.39 17.94 92.48 43.45 20.01 93.32 44.64 19.49 3 0 1000.00-999 ?-999 ?-999 ? mVAL.A 41 90.50 42.51 19.22 90.23 42.74 20.15 89.55 42.92 17.02 89.23 44.16 17.17 89.59 41.95 18.24 88.18 41.83 18.81 3 0 1000.00-999 ?-999 ?-999 ? mGLY.A 42 89.93 42.36 15.87 90.27 41.42 15.93 91.19 43.46 14.01 91.26 43.53 12.77 89.86 43.08 14.63-999.99-999.99-999.99 1 0 1000.00-999 ?-999 ?-999 ? mLEU.A 43 92.22 43.71 14.84 91.99 43.58 15.81 94.12 43.36 13.18 94.12 42.12 13.13 93.57 44.13 14.37 94.61 44.04 15.46 3 0 1000.00-999 ?-999 ?-999 ? mGLU.A 44 94.63 44.09 12.21 94.59 45.08 12.32 96.70 43.41 11.18 97.31 42.46 10.75 95.20 43.41 11.09 94.70 44.00 9.80 2 0 1000.00-999 ?-999 ?-999 ? mARG^A 45 97.29 44.48 11.73 96.65 45.22 11.92 99.05 45.69 13.02 98.21 46.53 13.35 98.74 44.56 12.02 99.61 44.63 10.73 2 0 1000.00-999 ?-999 ?-999 ? mPHE^A 46 100.27 45.69 13.53 100.84 44.90 13.29 102.18 46.99 14.23 102.90 46.10 13.81 100.70 46.76 14.37 100.36 46.45 15.82 3 0 1000.00-999 ?-999 ?-999 ? mGLU^A 47 102.63 48.17 14.62 101.93 48.85 14.85 104.41 49.04 16.02 103.64 49.84 16.57 104.07 48.42 14.67 104.54 49.30 13.50 2 0 1000.00-999 ?-999 ?-999 ? mILE^A 48 105.54 48.63 16.60 105.94 47.79 16.24 107.06 50.40 17.00 108.12 50.00 16.64 106.10 49.41 17.68 106.85 48.53 18.75 3 0 1000.00-999 ?-999 ?-999 ? mLEU^A 49 106.67 51.66 16.84 105.77 51.85 17.24 108.62 53.17 17.01 109.70 53.44 16.53 107.48 52.67 16.14 106.64 53.89 15.77 3 0 1000.00-999 ?-999 ?-999 ? mVAL^A 50 108.36 53.34 18.30 107.41 53.15 18.58 109.28 52.92 20.45 108.18 52.79 21.06 109.37 53.76 19.20 109.29 55.28 19.53 3 0 1000.00-999 ?-999 ?-999 ? mASP^A 51 110.41 52.32 20.81 111.20 52.50 20.22 111.52 51.94 22.89 112.69 51.64 22.65 110.45 51.47 21.97 110.74 50.02 21.64 2 0 1000.00-999 ?-999 ?-999 ? mASP.A 52 111.12 52.66 23.95 110.14 52.86 23.96 111.98 52.27 26.25 112.46 52.68 27.28 112.04 53.12 24.98 111.78 54.59 25.31 2 0 1000.00-999 ?-999 ?-999 ? mGLY.A 53 111.37 51.09 26.17 110.92 50.92 25.29 110.15 50.27 28.17 109.24 49.41 28.12 111.38 50.15 27.29-999.99-999.99-999.99 1 0 1000.00-999 ?-999 ?-999 ? mASP.A 54 110.14 51.33 28.97 111.00 51.83 29.04 107.98 52.64 28.89 106.95 53.05 29.38 108.95 51.71 29.69 109.35 52.32 31.04 2 0 1000.00-999 ?-999 ?-999 ? mARG^A 55 108.31 52.95 27.65 109.08 52.45 27.26 107.52 53.62 25.49 108.55 53.50 24.86 107.57 53.97 26.97 108.20 55.34 27.26 2 0 1000.00-999 ?-999 ?-999 ? mLEU^A 56 106.33 53.37 24.96 105.55 53.48 25.58 105.29 53.87 22.79 104.24 54.26 23.33 106.23 52.97 23.57 105.66 51.54 23.41 3 0 1000.00-999 ?-999 ?-999 ? mHIS^A 57 105.65 54.15 21.54 106.58 53.92 21.29 104.35 53.74 19.58 105.21 53.09 18.99 104.70 54.77 20.65 105.21 56.12 20.13 3 0 1000.00-999 ?-999 ?-999 ? mARG^A 58 103.05 53.54 19.39 102.45 54.17 19.88 101.60 52.80 17.44 100.92 53.82 17.49 102.61 52.45 18.50 102.15 51.27 19.34 2 0 1000.00-999 ?-999 ?-999 ? mARG^A 59 101.53 51.95 16.45 102.17 51.19 16.49 99.74 50.88 15.31 100.30 49.79 15.16 100.54 52.17 15.41 101.24 52.51 14.10 2 0 1000.00-999 ?-999 ?-999 ? mLEU^A 60 98.44 51.01 15.44 98.13 51.94 15.65 96.73 49.98 14.01 96.18 51.06 13.72 97.55 49.85 15.27 96.62 49.68 16.46 3 0 1000.00-999 ?-999 ?-999 ? mTYR^A 61 96.66 48.88 13.27 97.20 48.12 13.62 94.59 48.03 12.27 94.63 46.80 12.30 95.86 48.84 12.04 96.66 48.24 10.87 3 0 1000.00-999 ?-999 ?-999 ? mLEU^A 62 93.48 48.74 12.43 93.63 49.73 12.48 91.40 48.26 11.20 91.76 49.09 10.35 92.16 48.12 12.52 91.38 48.77 13.64 3 0 1000.00-999 ?-999 ?-999 ? mPRO.A 63 90.31 47.49 11.01 90.01 46.90 11.77 89.06 48.99 9.47 88.42 49.54 10.38 89.68 47.60 9.69 88.65 46.46 9.68 3 0 1000.00-999 ?-999 ?-999 ? mGLY.A 64 89.32 49.60 8.31 89.80 49.03 7.65 89.38 52.02 9.10 88.78 53.10 9.18 88.91 50.98 8.08-999.99-999.99-999.99 1 0 1000.00-999 ?-999 ?-999 ? mLEU^A 65 90.45 51.73 9.85 90.90 50.87 9.64 92.35 52.48 11.35 92.75 51.40 11.84 90.89 52.64 10.90 90.01 52.39 12.15 3 0 1000.00-999 ?-999 ?-999 ? mVAL^A 66 93.12 53.56 11.26 92.71 54.34 10.80 94.55 54.35 13.10 94.11 55.47 13.15 94.48 53.54 11.81 95.50 54.06 10.80 3 0 1000.00-999 ?-999 ?-999 ? mVAL^A 67 95.14 53.77 14.15 95.45 52.84 13.99 96.82 54.51 15.81 97.53 53.51 15.75 95.31 54.42 15.42 94.68 53.52 16.52 3 0 1000.00-999 ?-999 ?-999 ? mGLU^A 68 97.27 55.67 16.28 96.63 56.44 16.19 98.44 56.21 18.32 97.58 57.04 18.66 98.58 55.81 16.86 99.43 56.83 16.13 2 0 1000.00-999 ?-999 ?-999 ? mASP^A 69 99.26 55.62 19.20 99.87 54.92 18.86 100.51 55.85 21.27 101.45 55.26 20.70 99.20 56.03 20.56 98.08 55.28 21.29 2 0 1000.00-999 ?-999 ?-999 ? mGLU^A 70 100.57 56.35 22.50 99.75 56.85 22.78 101.28 55.36 24.54 100.13 55.40 24.96 101.70 56.20 23.36 102.23 57.55 23.88 2 0 1000.00-999 ?-999 ?-999 ? mVAL^A 71 102.21 54.60 25.09 103.11 54.68 24.65 103.05 53.96 27.19 104.20 53.80 26.77 101.93 53.74 26.23 101.99 52.29 25.86 3 0 1000.00-999 ?-999 ?-999 ? mVAL^A 72 102.75 54.31 28.44 101.78 54.51 28.58 103.59 53.24 30.50 102.48 52.99 30.99 103.76 54.41 29.50 103.66 55.75 30.24 3 0 1000.00-999 ?-999 ?-999 ? mLEU^A 73 104.65 52.50 30.75 105.48 52.77 30.27 105.26 51.78 32.98 106.38 52.25 32.96 104.55 51.38 31.68 105.19 50.10 31.09 3 0 1000.00-999 ?-999 ?-999 ? mLYS^A 74 104.57 51.64 34.10 103.60 51.43 33.97 105.14 50.46 36.19 104.17 50.18 36.89 105.20 51.77 35.39 104.54 52.90 36.18 2 0 1000.00-999 ?-999 ?-999 ? mALA.A 75 106.19 49.65 36.06 106.91 50.02 35.47 106.38 48.51 38.21 107.14 49.37 38.70 106.28 48.34 36.71 107.48 47.53 36.18 2 0 1000.00-999 ?-999 ?-999 ? mPRO.A 76 105.64 47.68 38.95 105.82 47.77 39.93 103.24 47.14 38.72 102.54 46.39 39.39 104.67 46.73 38.40 104.98 45.46 39.18 3 0 1000.00-999 ?-999 ?-999 ? mASP.A 77 102.81 48.32 38.30 103.38 48.75 37.60 100.62 49.29 37.77 99.41 49.02 37.92 101.61 48.91 38.83 101.97 50.10 39.67 2 0 1000.00-999 ?-999 ?-999 ? mSER^A 78 101.11 49.86 36.66 102.10 49.87 36.54 100.70 50.62 34.31 101.92 50.76 34.10 100.18 50.40 35.72 99.60 51.72 36.26 2 0 1000.00-999 ?-999 ?-999 ? mALA^A 79 99.72 50.67 33.37 98.79 50.49 33.71 99.04 52.12 31.63 97.80 52.05 31.88 99.93 50.95 31.99 99.59 49.73 31.16 2 0 1000.00-999 ?-999 ?-999 ? mHIS^A 80 99.60 53.18 31.05 100.58 53.08 30.88 98.86 54.58 29.17 99.94 54.76 28.59 98.83 54.38 30.70 99.41 55.59 31.46 3 0 1000.00-999 ?-999 ?-999 ? mTYR^A 81 97.70 54.52 28.52 96.91 54.42 29.13 97.10 55.96 26.66 96.10 56.38 27.25 97.61 54.60 27.04 96.57 53.60 26.53 3 0 1000.00-999 ?-999 ?-999 ? mSER^A 82 97.67 56.65 25.70 98.48 56.26 25.26 97.17 58.30 23.89 98.11 57.90 23.21 97.06 57.92 25.37 97.62 59.01 26.25 2 0 1000.00-999 ?-999 ?-999 ? mILE^A 83 96.18 59.06 23.40 95.45 59.27 24.06 96.02 61.03 22.04 95.13 61.53 22.67 96.14 59.52 22.05 94.88 58.88 21.27 3 0 1000.00-999 ?-999 ?-999 ? mLYS.A 84 96.90 61.75 21.35 97.64 61.23 20.93 95.62 63.58 20.25 95.56 62.97 19.16 96.70 63.21 21.27 97.98 64.08 21.08 2 0 1000.00-999 ?-999 ?-999 ? mPRO.A 85 94.74 64.54 20.59 94.86 64.99 21.47 94.23 65.81 18.63 95.22 66.54 18.88 93.70 64.85 19.67 92.72 65.60 20.53 3 0 1000.00-999 ?-999 ?-999 ? mSER.A 86 93.53 65.83 17.51 92.71 65.27 17.55 92.60 67.25 15.90 91.54 67.12 16.54 93.88 66.57 16.34 94.17 65.57 15.21 2 0 1000.00-999 ?-999 ?-999 ? mALA.A 87 92.70 67.88 14.74 93.62 67.90 14.36 90.43 67.51 13.91 89.29 67.85 14.16 91.58 68.50 14.08 92.01 69.09 12.73 2 0 1000.00-999 ?-999 ?-999 ? mGLU.A 88 90.72 66.28 13.50 91.69 66.03 13.45 89.38 64.18 14.04 88.28 63.62 14.03 89.58 65.40 13.15 89.50 65.07 11.65 2 0 1000.00-999 ?-999 ?-999 ? mVAL.A 89 90.38 63.80 14.82 91.26 64.23 14.66 90.22 63.32 17.27 91.02 64.21 17.59 90.12 62.79 15.83 90.97 61.46 15.63 3 0 1000.00-999 ?-999 ?-999 ? mALA.A 90 89.38 62.74 18.13 88.77 62.06 17.71 90.38 62.27 20.22 90.63 61.13 19.83 89.33 63.08 19.54 87.98 62.78 20.14 2 0 1000.00-999 ?-999 ?-999 ? mGLY^A 91 90.99 62.85 21.25 90.66 63.76 21.50 91.48 61.45 23.10 90.26 61.39 23.26 92.06 62.19 21.93-999.99-999.99-999.99 1 0 1000.00-999 ?-999 ?-999 ? mGLY^A 92 92.35 60.91 23.93 93.31 60.93 23.66 92.96 59.53 25.82 94.11 59.53 25.43 91.90 60.36 25.15-999.99-999.99-999.99 1 0 1000.00-999 ?-999 ?-999 ? mSER^A 93 92.56 58.82 26.85 91.59 58.88 27.08 92.83 56.85 28.23 91.62 56.87 28.47 93.51 58.03 27.57 94.23 58.90 28.59 2 0 1000.00-999 ?-999 ?-999 ? mLEU^A 94 93.61 55.81 28.47 94.53 55.87 28.08 94.24 54.36 30.28 95.40 54.20 29.91 93.14 54.67 29.23 92.92 53.50 28.28 3 0 1000.00-999 ?-999 ?-999 ? mASP^A 95 93.90 54.31 31.56 92.95 54.60 31.71 94.40 52.49 33.17 93.21 52.26 33.48 94.81 53.86 32.62 94.83 54.88 33.75 2 0 1000.00-999 ?-999 ?-999 ? mMETA 96 95.35 51.57 33.26 96.21 51.84 32.84 96.02 50.19 35.12 97.24 50.28 34.99 95.14 50.28 33.90 95.57 49.18 32.97 2 0 1000.00-999 ?-999 ?-999 ? mTHR^A 97 95.43 50.01 36.28 94.44 49.84 36.22 95.91 48.84 38.35 94.77 48.49 38.53 96.18 50.07 37.55 95.77 51.31 38.43 2 0 1000.00-999 ?-999 ?-999 ? mILE^A 98 96.95 48.19 38.83 97.84 48.60 38.62 96.43 47.37 41.04 97.06 48.30 41.59 96.76 46.98 39.60 97.98 46.08 39.58 3 0 1000.00-999 ?-999 ?-999 ? mGLU^A 99 95.42 46.73 41.63 94.91 46.10 41.04 95.14 45.65 43.76 94.68 44.62 43.27 95.11 46.96 43.03 93.74 47.58 43.21 2 0 1000.00-999 ?-999 ?-999 ? mGLU^A 100 95.68 45.69 44.96 95.98 46.60 45.26 95.60 44.82 47.21 96.56 45.12 47.92 95.81 44.49 45.73 97.19 43.85 45.46 2 0 1000.00-999 ?-999 ?-999 ? mPRO^A 101 94.34 44.83 47.67 93.69 44.65 46.93 94.61 44.09 50.04 94.74 44.36 51.28 93.94 45.06 49.08 92.46 44.71 49.11 3 0 1000.00-999 ?-999 ?-999 ? mGLU^A 102 94.96 42.93 49.50 94.78 42.86 48.52 96.19 40.87 49.36 95.75 40.78 48.19 95.55 41.85 50.31 94.48 41.13 51.17 2 0 1000.00-999 ?-999 ?-999 ? mPRO.A 103 97.22 40.15 49.83 97.40 40.25 50.81 97.06 38.26 48.32 96.19 37.69 49.00 97.99 39.28 48.94 99.04 38.58 49.87 3 0 1000.00-999 ?-999 ?-999 ? mGLY.A 104 97.21 38.08 47.02 97.97 38.59 46.62 95.00 37.82 45.88 94.37 37.35 44.94 96.33 37.23 46.24-999.99-999.99-999.99 1 0 1000.00-999 ?-999 ?-999 ? mSER^A 105 94.56 38.84 46.60 95.09 39.08 47.42 93.69 40.67 45.20 94.17 41.70 45.60 93.36 39.53 46.17 92.56 40.04 47.33 2 0 1000.00-999 ?-999 ?-999 ? mLEU^A 106 93.44 40.45 43.91 92.91 39.61 43.74 92.79 41.97 42.04 91.81 41.31 41.78 93.92 41.38 42.86 94.91 40.68 41.90 3 0 1000.00-999 ?-999 ?-999 ? mPHE^A 107 92.94 43.22 41.63 93.82 43.63 41.89 92.68 44.75 39.87 93.84 45.12 40.15 91.93 43.93 40.88 91.17 44.86 41.78 3 0 1000.00-999 ?-999 ?-999 ? mVAL^A 108 92.05 45.06 38.74 91.20 44.56 38.56 91.51 47.11 37.60 90.40 46.82 37.12 92.58 46.03 37.84 92.95 45.41 36.47 3 0 1000.00-999 ?-999 ?-999 ? mARG^A 109 91.82 48.35 37.97 92.68 48.42 38.47 91.29 49.96 36.26 92.44 50.22 35.92 90.99 49.49 37.66 91.38 50.64 38.59 2 0 1000.00-999 ?-999 ?-999 ? mPHE^A 110 90.25 50.10 35.44 89.39 49.79 35.85 89.75 52.05 34.09 88.55 52.22 34.43 90.36 50.67 34.09 89.56 49.83 33.13 3 0 1000.00-999 ?-999 ?-999 ? mALA^A 111 90.53 53.04 33.73 91.46 52.79 33.46 90.03 55.10 32.39 91.08 55.21 31.82 89.97 54.42 33.77 90.73 55.28 34.85 2 0 1000.00-999 ?-999 ?-999 ? mTYR^A 112 88.92 55.58 31.86 88.11 55.52 32.45 88.64 57.62 30.53 87.84 58.11 31.33 88.93 56.15 30.52 87.91 55.52 29.59 3 0 1000.00-999 ?-999 ?-999 ? mCYH^A 113 89.25 58.33 29.60 89.98 57.88 29.10 88.97 60.04 27.92 89.57 59.33 27.17 88.83 59.70 29.38 89.57 60.71 30.27 2 0 1000.00-999 ?-999 ?-999 ? mTHR^A 114 88.31 61.13 27.53 87.83 61.59 28.28 88.68 63.11 26.30 88.18 63.78 27.16 88.27 61.63 26.19 86.83 61.58 25.67 2 0 1000.00-999 ?-999 ?-999 ? mARG^A 115 89.57 63.60 25.44 90.10 62.92 24.93 89.59 65.58 23.83 89.88 64.88 22.86 89.73 65.06 25.28 91.03 65.55 25.93 2 0 1000.00-999 ?-999 ?-999 ? mTYR.A 116 89.11 66.81 23.65 88.80 67.26 24.49 90.05 68.54 22.21 90.55 68.99 23.24 89.07 67.39 22.30 87.67 67.87 21.93 3 0 1000.00-999 ?-999 ?-999 ? mLEU.A 117 90.36 69.03 21.01 90.01 68.50 20.23 90.37 71.47 21.51 90.82 72.08 22.46 91.14 70.26 20.91 91.64 70.47 19.47 3 0 1000.00-999 ?-999 ?-999 ? mPRO.A 119 86.75 72.67 23.58 86.98 73.64 23.68 84.43 72.24 24.54 83.71 71.90 25.48 85.94 71.93 24.56 86.60 72.34 25.89 3 0 1000.00-999 ?-999 ?-999 ? mASP.A 122 80.01 72.97 30.57 80.47 73.85 30.61 80.37 70.56 30.42 81.18 70.56 29.49 79.33 71.68 30.50 78.38 71.63 29.28 2 0 1000.00-999 ?-999 ?-999 ? mGLU.A 123 80.36 69.67 31.43 79.75 69.94 32.17 80.30 67.28 30.87 79.07 67.32 30.97 81.16 68.42 31.48 81.55 68.10 32.92 2 0 1000.00-999 ?-999 ?-999 ? mLEU.A 124 80.93 66.29 30.24 81.89 66.19 30.48 80.20 63.93 29.58 81.26 63.32 29.53 80.19 65.44 29.27 80.78 65.63 27.86 3 0 1000.00-999 ?-999 ?-999 ? mPRO.A 125 79.03 63.32 29.86 78.19 63.86 29.80 79.18 60.96 28.99 78.68 61.32 27.93 79.12 61.90 30.23 77.85 61.66 31.03 3 0 1000.00-999 ?-999 ?-999 ? mTYR.A 126 79.85 59.81 29.10 80.48 59.77 29.87 78.24 58.14 28.27 77.68 58.10 29.38 79.66 58.72 28.17 80.60 57.62 28.53 3 0 1000.00-999 ?-999 ?-999 ? mASP~A 127 77.64 57.74 27.14 78.11 58.01 26.30 76.66 55.48 27.51 77.83 55.00 27.56 76.40 56.96 27.17 75.67 57.03 25.81 2 0 1000.00-999 ?-999 ?-999 ? mALA~A 128 75.57 54.73 27.67 74.70 55.14 27.42 76.24 52.35 27.17 76.94 51.41 27.54 75.75 53.37 28.21 74.50 52.89 29.00 2 0 1000.00-999 ?-999 ?-999 ? mPHE~A 129 75.95 52.57 25.90 75.28 53.30 25.74 78.06 51.79 24.93 78.71 50.77 24.68 76.59 51.76 24.85 76.18 52.22 23.47 3 0 1000.00-999 ?-999 ?-999 ? mVAL~A 130 78.62 52.96 25.25 77.98 53.72 25.39 80.45 52.38 26.68 81.39 51.63 26.71 80.05 53.06 25.39 80.50 54.55 25.38 3 0 1000.00-999 ?-999 ?-999 ? mLYS~A 131 79.72 52.62 27.76 78.93 53.21 27.64 80.10 50.49 28.93 81.04 49.83 29.33 80.14 51.99 29.03 79.37 52.49 30.24 2 0 1000.00-999 ?-999 ?-999 ? mGLN~A 132 79.06 49.98 28.29 78.42 50.65 27.94 80.04 48.02 27.29 80.59 46.98 27.61 78.90 48.54 28.14 77.52 48.21 27.55 2 0 1000.00-999 ?-999 ?-999 ? mALA~A 133 80.46 48.76 26.27 79.98 49.63 26.13 82.87 48.29 26.18 83.73 47.44 25.95 81.56 48.26 25.44 81.64 48.99 24.06 2 0 1000.00-999 ?-999 ?-999 ? mTYR~A 134 83.06 49.23 27.11 82.28 49.83 27.30 84.42 48.15 28.77 85.44 47.47 28.86 84.34 49.29 27.79 84.46 50.60 28.55 3 0 1000.00-999 ?-999 ?-999 ? mILE~A 135 83.34 48.00 29.54 82.66 48.73 29.45 83.48 45.58 29.69 84.33 44.82 30.10 83.16 46.88 30.44 81.72 46.91 31.07 3 0 1000.00-999 ?-999 ?-999 ? mALA~A 136 82.85 45.33 28.57 82.16 46.01 28.31 84.72 43.99 27.52 85.31 42.93 27.71 83.21 44.12 27.81 82.41 43.96 26.54 2 0 1000.00-999 ?-999 ?-999 ? mMETA 137 85.36 45.06 27.07 84.83 45.90 26.98 87.62 44.63 27.96 88.51 43.76 27.85 86.77 44.91 26.76 87.30 46.13 26.10 2 0 1000.00-999 ?-999 ?-999 ? mASP~A 138 87.35 45.34 29.08 86.58 45.98 29.03 88.06 43.70 30.79 89.07 43.09 31.13 88.15 45.15 30.25 87.83 46.17 31.35 2 0 1000.00-999 ?-999 ?-999 ? mVAL~A 139 86.86 43.15 30.83 86.11 43.76 30.57 87.35 40.81 30.24 88.06 39.90 30.68 86.65 41.79 31.22 85.15 41.52 31.41 3 0 1000.00-999 ?-999 ?-999 ? mGLU~A 140 87.21 41.01 28.93 86.58 41.73 28.67 89.51 40.33 28.17 90.24 39.36 28.04 87.98 40.17 27.99 87.50 40.34 26.55 2 0 1000.00-999 ?-999 ?-999 ? mTHR~A 141 89.99 41.51 28.54 89.32 42.24 28.68 91.89 40.81 29.91 92.92 40.14 29.82 91.40 41.67 28.73 91.80 43.12 29.04 2 0 1000.00-999 ?-999 ?-999 ? mILE~A 142 91.18 40.85 31.02 90.37 41.44 30.99 91.42 38.60 31.84 92.22 37.77 32.29 91.57 40.08 32.17 90.72 40.45 33.41 3 0 1000.00-999 ?-999 ?-999 ? mALA~A 143 90.43 38.25 31.04 89.87 39.00 30.69 91.44 36.35 29.97 92.00 35.31 30.30 90.22 36.82 30.74 88.96 36.60 29.94 2 0 1000.00-999 ?-999 ?-999 ? mTHR~A 144 91.86 37.11 28.96 91.31 37.93 28.79 94.32 36.60 29.01 95.08 35.61 28.86 93.02 36.76 28.16 93.24 37.78 27.06 2 0 1000.00-999 ?-999 ?-999 ? mILE~A 145 94.57 37.56 29.89 93.91 38.31 29.91 95.64 36.16 31.53 96.57 35.33 31.50 95.72 37.48 30.74 95.81 38.71 31.67 3 0 1000.00-999 ?-999 ?-999 ? mARG~A 146 94.52 35.94 32.19 93.84 36.66 32.11 94.58 33.51 32.12 95.13 32.56 32.59 94.31 34.74 32.98 92.89 34.74 33.50 2 0 1000.00-999 ?-999 ?-999 ? mASP~A 147 94.22 33.51 30.84 93.80 34.36 30.51 95.90 32.17 29.68 96.42 31.09 29.68 94.45 32.28 30.06 93.61 32.19 28.77 2 0 1000.00-999 ?-999 ?-999 ? mARG~A 148 96.55 33.26 29.34 96.00 34.10 29.37 98.97 33.11 30.11 100.06 32.63 29.88 97.96 33.21 28.97 98.36 34.43 28.11 2 0 1000.00-999 ?-999 ?-999 ? mPHE~A 149 98.62 33.58 31.32 97.65 33.82 31.38 99.19 33.04 33.71 99.95 33.03 34.68 99.60 33.73 32.43 99.92 35.22 32.75 3 0 1000.00-999 ?-999 ?-999 ? mGLY~A 150 98.00 32.48 33.76 97.34 32.83 33.09 98.39 30.15 34.23 98.73 29.27 35.05 97.73 31.43 34.76-999.99-999.99-999.99 1 0 1000.00-999 ?-999 ?-999 ? mALA.A 151 98.58 30.06 32.89 98.28 30.89 32.41 100.71 28.65 32.24 101.54 29.59 32.30 99.16 28.88 32.17 98.64 28.79 30.66 2 0 1000.00-999 ?-999 ?-999 ? mMETB 1 77.82 63.40 16.41 77.25 64.18 16.14 78.23 60.81 16.32 77.47 60.13 17.01 78.68 62.22 16.81 78.81 62.19 18.34 2 0 1000.00-999 ?-999 ?-999 ? mGLN^B 2 78.71 60.37 15.14 79.43 60.95 14.77 79.35 58.21 14.16 80.30 58.61 13.53 78.20 59.16 14.48 77.49 59.56 13.18 2 0 1000.00-999 ?-999 ?-999 ? mPHE^B 3 79.28 56.96 14.59 78.52 56.79 15.21 79.58 54.79 13.48 78.61 54.27 13.97 80.26 55.95 14.16 81.08 55.43 15.34 3 0 1000.00-999 ?-999 ?-999 ? mGLU^B 4 80.14 54.33 12.39 80.99 54.79 12.14 80.63 52.20 11.26 81.73 52.55 10.85 79.58 53.25 11.61 78.96 53.82 10.32 2 0 1000.00-999 ?-999 ?-999 ? mHIS^B 5 80.28 50.92 11.41 79.33 50.83 11.72 80.37 48.70 10.41 79.26 48.35 10.84 81.18 49.77 11.15 81.73 49.16 12.45 3 0 1000.00-999 ?-999 ?-999 ? mLEU^B 6 80.89 48.20 9.30 81.79 48.56 9.07 80.81 45.84 8.80 82.02 45.72 8.73 80.17 47.18 8.49 80.27 47.52 7.02 3 0 1000.00-999 ?-999 ?-999 ? mVAL^B 7 80.06 44.85 9.24 79.08 45.04 9.34 80.28 42.59 8.45 79.08 42.42 8.20 80.70 43.58 9.52 80.36 43.02 10.92 3 0 1000.00-999 ?-999 ?-999 ? mGLN^B 8 81.25 41.96 7.78 82.17 42.26 8.04 80.53 39.64 7.47 81.23 39.14 8.35 80.96 40.94 6.78 82.19 40.69 5.91 2 0 1000.00-999 ?-999 ?-999 ? mVAL.B 9 79.38 39.10 7.10 78.93 39.56 6.33 79.46 36.56 7.37 79.82 35.75 8.24 78.85 37.93 7.80 77.33 37.90 7.71 3 0 1000.00-999 ?-999 ?-999 ? mASN.B 10 79.55 36.31 6.06 79.23 37.06 5.49 81.39 35.31 4.76 81.58 36.41 4.23 80.08 35.06 5.51 79.07 34.46 4.53 2 0 1000.00-999 ?-999 ?-999 ? mASP.B 11 82.26 34.29 4.68 81.95 33.47 5.16 83.88 33.04 3.31 83.12 32.10 3.46 83.57 34.38 3.97 84.71 34.79 4.91 2 0 1000.00-999 ?-999 ?-999 ? mARG.B 12 84.98 32.95 2.55 85.44 33.82 2.39 86.56 31.06 2.90 87.66 31.63 3.04 85.45 31.65 2.01 85.90 31.76 0.56 2 0 1000.00-999 ?-999 ?-999 ? mTHR.B 13 86.23 29.92 3.52 85.38 29.53 3.17 86.78 27.76 4.68 85.87 27.29 5.37 87.02 29.30 4.60 86.71 29.97 5.98 2 0 1000.00-999 ?-999 ?-999 ? mASP.B 16 85.93 25.87 7.74 85.89 25.86 6.75 84.70 26.48 9.83 84.02 25.80 10.59 85.97 25.89 9.21 87.22 26.62 9.71 2 0 1000.00-999 ?-999 ?-999 ? mLEU.B 17 84.38 27.73 9.50 85.00 28.13 8.83 81.84 28.16 9.34 81.82 27.88 8.14 83.21 28.43 10.07 83.48 29.93 10.18 3 0 1000.00-999 ?-999 ?-999 ? mPRO.B 18 80.71 28.24 10.08 80.83 28.44 11.05 78.84 29.22 8.63 79.04 30.38 9.00 79.40 28.02 9.43 78.46 27.69 10.62 3 0 1000.00-999 ?-999 ?-999 ? mVAL.B 19 78.13 28.90 7.54 78.07 27.91 7.42 76.12 30.26 7.15 75.48 29.47 7.85 77.50 29.85 6.61 77.24 29.19 5.23 3 0 1000.00-999 ?-999 ?-999 ? mLEU.B 20 75.64 31.46 6.81 76.23 31.95 6.16 73.44 32.49 6.21 73.90 33.17 5.30 74.37 32.00 7.33 74.69 33.17 8.23 3 0 1000.00-999 ?-999 ?-999 ? mASP~B 21 72.15 32.14 6.26 71.92 31.45 6.94 70.60 34.00 6.01 70.87 34.28 7.19 71.18 32.75 5.35 70.05 31.78 4.96 2 0 1000.00-999 ?-999 ?-999 ? mARG~B 22 69.81 34.75 5.26 69.58 34.36 4.37 68.40 35.92 6.93 68.49 36.71 7.88 69.33 36.03 5.72 68.67 36.83 4.59 2 0 1000.00-999 ?-999 ?-999 ? mLEU~B 23 67.51 34.92 6.90 67.55 34.34 6.09 67.28 34.22 9.28 66.91 34.58 10.40 66.57 34.73 7.99 65.39 33.87 7.55 3 0 1000.00-999 ?-999 ?-999 ? mGLN~B 24 68.37 33.47 9.10 68.59 33.28 8.15 69.85 34.12 10.83 69.90 34.21 12.06 69.14 32.98 10.21 70.10 31.93 9.73 2 0 1000.00-999 ?-999 ?-999 ? mLEU~B 25 70.37 35.01 9.99 70.26 34.78 9.02 70.11 37.11 11.27 70.48 37.60 12.35 71.05 36.23 10.48 71.53 37.03 9.31 3 0 1000.00-999 ?-999 ?-999 ? mTRP~B 26 68.92 37.31 10.70 68.84 36.94 9.78 67.48 37.37 12.72 67.31 38.06 13.69 67.83 38.00 11.36 66.61 38.10 10.44 3 0 1000.00-999 ?-999 ?-999 ? mGLU~B 27 67.38 36.05 12.80 67.54 35.56 11.94 68.15 35.77 15.07 67.89 36.02 16.24 67.05 35.42 14.09 66.90 33.90 13.96 2 0 1000.00-999 ?-999 ?-999 ? mGLY~B 28 69.37 35.84 14.58 69.48 35.57 13.62 70.22 37.67 16.05 70.48 37.84 17.25 70.46 36.30 15.40-999.99-999.99-999.99 1 0 1000.00-999 ?-999 ?-999 ? mLEU~B 29 69.75 38.65 15.26 69.55 38.37 14.32 68.44 40.03 16.79 68.51 40.76 17.78 69.56 40.02 15.76 69.19 40.93 14.60 3 0 1000.00-999 ?-999 ?-999 ? mVAL~B 30 67.40 39.22 16.55 67.44 38.72 15.69 66.90 38.52 18.80 66.70 39.06 19.90 66.31 39.09 17.48 65.17 38.16 16.87 3 0 1000.00-999 ?-999 ?-999 ? mCYH~B 31 67.65 37.45 18.66 67.77 37.13 17.72 69.08 37.77 20.65 69.13 37.64 21.89 68.26 36.81 19.79 69.17 35.72 19.29 2 0 1000.00-999 ?-999 ?-999 ? mARG~B 32 69.71 38.74 19.98 69.53 38.77 18.99 69.72 40.59 21.44 70.06 40.89 22.56 70.60 39.66 20.62 71.43 40.35 19.53 2 0 1000.00-999 ?-999 ?-999 ? mALA~B 33 68.60 41.00 20.89 68.50 40.71 19.94 66.83 41.10 22.74 66.61 41.70 23.78 67.59 41.80 21.58 66.59 42.35 20.55 2 0 1000.00-999 ?-999 ?-999 ? mARG~B 34 66.44 39.84 22.55 66.75 39.44 21.68 66.43 38.32 24.57 65.92 37.96 25.63 65.63 39.13 23.56 64.63 38.22 22.88 2 0 1000.00-999 ?-999 ?-999 ? mGLU~B 35 67.67 37.99 24.23 67.99 38.41 23.38 69.88 37.68 25.16 70.85 37.03 24.79 68.47 37.12 25.04 68.49 35.71 24.42 2 0 1000.00-999 ?-999 ?-999 ? mPRO~B 36 70.00 38.90 25.70 69.15 39.30 26.04 72.36 38.83 26.66 73.56 39.10 26.53 71.30 39.57 25.78 70.93 40.94 26.37 3 0 1000.00-999 ?-999 ?-999 ? mGLN~B 37 71.95 37.88 27.49 70.96 37.73 27.51 73.97 36.40 27.36 75.03 36.01 27.80 72.98 37.15 28.27 72.38 36.17 29.30 2 0 1000.00-999 ?-999 ?-999 ? mTYR~B 38 73.63 36.19 26.10 72.75 36.59 25.83 75.47 36.36 24.50 76.40 35.91 23.85 74.49 35.42 25.20 73.67 34.58 24.17 3 0 1000.00-999 ?-999 ?-999 ? mPHE~B 39 75.27 37.67 24.63 74.51 37.90 25.24 76.71 39.72 24.79 77.49 40.53 24.29 76.10 38.65 23.92 75.22 39.40 22.96 3 0 1000.00-999 ?-999 ?-999 ? mVAL.B 40 76.28 39.84 26.04 75.64 39.15 26.37 77.65 40.44 27.94 77.17 39.90 28.94 76.76 40.95 26.81 75.67 41.94 27.22 3 0 1000.00-999 ?-999 ?-999 ? mVAL.B 41 78.96 40.55 27.68 79.18 40.84 26.75 79.76 41.20 29.88 79.71 42.44 29.75 79.96 40.27 28.67 81.43 40.37 28.09 3 0 1000.00-999 ?-999 ?-999 ? mGLY.B 42 79.61 40.57 31.04 79.60 39.57 31.01 78.08 41.28 32.83 77.95 41.41 34.05 79.46 41.31 32.24-999.99-999.99-999.99 1 0 1000.00-999 ?-999 ?-999 ? mLEU.B 43 77.06 41.11 31.99 77.34 40.94 31.04 75.41 40.27 33.59 75.91 39.15 33.61 75.67 41.18 32.41 74.75 40.80 31.24 3 0 1000.00-999 ?-999 ?-999 ? mGLU.B 44 74.61 40.73 34.56 74.23 41.64 34.39 72.89 39.42 35.70 72.60 38.31 36.14 74.32 39.94 35.76 74.59 40.77 37.03 2 0 1000.00-999 ?-999 ?-999 ? mARG^B 45 71.99 40.25 35.18 72.33 41.18 35.04 69.96 40.89 34.00 70.54 41.96 33.74 70.64 39.82 34.85 69.81 39.35 36.07 2 0 1000.00-999 ?-999 ?-999 ? mPHE^B 46 68.75 40.59 33.54 68.40 39.68 33.77 66.55 41.26 32.82 66.16 40.10 33.01 68.01 41.55 32.75 68.47 41.51 31.30 3 0 1000.00-999 ?-999 ?-999 ? mGLU^B 47 65.73 42.29 32.67 66.18 43.18 32.63 63.80 42.54 31.23 64.39 43.40 30.57 64.28 42.11 32.59 63.54 42.93 33.64 2 0 1000.00-999 ?-999 ?-999 ? mILE^B 48 62.73 41.93 30.78 62.48 41.09 31.24 60.81 43.16 30.36 59.91 42.45 30.73 62.02 42.52 29.68 61.64 41.46 28.67 3 0 1000.00-999 ?-999 ?-999 ? mLEU^B 49 60.85 44.48 30.57 61.66 44.92 30.18 58.52 45.34 30.49 57.42 45.19 31.02 59.81 45.21 31.30 60.31 46.60 31.67 3 0 1000.00-999 ?-999 ?-999 ? mVAL^B 50 58.66 45.64 29.19 59.60 45.81 28.89 57.90 44.94 27.04 59.04 45.09 26.53 57.51 45.70 28.30 57.00 47.17 28.01 3 0 1000.00-999 ?-999 ?-999 ? mASP^B 51 56.98 44.08 26.60 56.16 44.03 27.16 55.96 43.47 24.49 54.97 42.79 24.71 57.17 43.30 25.38 57.38 41.79 25.71 2 0 1000.00-999 ?-999 ?-999 ? mASP.B 52 56.06 44.37 23.50 56.90 44.91 23.54 55.37 43.80 21.16 54.86 44.15 20.10 55.02 44.54 22.46 54.87 46.01 22.05 2 0 1000.00-999 ?-999 ?-999 ? mGLY.B 53 56.28 42.82 21.22 56.72 42.70 22.11 57.75 42.53 19.23 58.86 42.02 19.38 56.57 42.00 20.02-999.99-999.99-999.99 1 0 1000.00-999 ?-999 ?-999 ? mASP.B 54 57.49 43.54 18.41 56.52 43.75 18.33 59.10 45.48 18.47 59.88 46.25 17.96 58.51 44.28 17.68 57.91 44.79 16.36 2 0 1000.00-999 ?-999 ?-999 ? mARG^B 55 58.68 45.66 19.71 58.11 44.92 20.07 59.23 46.37 21.89 58.28 45.83 22.49 59.03 46.85 20.46 57.89 47.89 20.34 2 0 1000.00-999 ?-999 ?-999 ? mLEU^B 56 60.45 46.49 22.41 61.10 46.92 21.79 61.36 47.19 24.65 62.16 48.01 24.19 60.79 46.06 23.77 61.83 44.92 23.75 3 0 1000.00-999 ?-999 ?-999 ? mHIS^B 57 61.00 47.21 25.92 60.26 46.57 26.15 62.31 47.18 27.90 61.63 46.34 28.52 61.65 48.08 26.88 60.62 49.03 27.51 3 0 1000.00-999 ?-999 ?-999 ? mARG^B 58 63.63 47.34 28.08 64.00 48.13 27.59 65.24 47.06 30.09 65.63 48.23 30.05 64.43 46.42 28.93 65.45 45.65 28.09 2 0 1000.00-999 ?-999 ?-999 ? mARG^B 59 65.49 46.27 31.12 64.97 45.42 31.17 67.66 45.72 32.02 67.46 44.49 31.95 66.49 46.68 32.09 65.93 46.77 33.51 2 0 1000.00-999 ?-999 ?-999 ? mLEU^B 60 68.86 46.31 31.98 68.81 47.31 31.97 70.92 45.83 33.22 71.21 46.98 33.56 70.13 45.60 31.94 70.96 46.10 30.78 3 0 1000.00-999 ?-999 ?-999 ? mTYR^B 61 71.25 44.75 33.93 70.91 43.89 33.56 73.50 44.47 34.88 73.81 43.26 34.83 72.05 44.87 35.15 71.49 44.03 36.29 3 0 1000.00-999 ?-999 ?-999 ? mLEU^B 62 74.36 45.49 34.69 73.92 46.39 34.69 76.51 45.60 35.82 75.92 46.24 36.71 75.80 45.29 34.51 76.32 46.17 33.36 3 0 1000.00-999 ?-999 ?-999 ? mPRO.B 63 77.78 45.15 35.99 78.20 44.66 35.22 78.57 46.96 37.56 79.10 47.72 36.69 78.43 45.44 37.30 79.82 44.81 37.15 3 0 1000.00-999 ?-999 ?-999 ? mGLY.B 64 78.10 47.38 38.73 77.77 46.64 39.32 77.29 49.71 38.15 77.54 50.91 38.13 78.06 48.79 39.10-999.99-999.99-999.99 1 0 1000.00-999 ?-999 ?-999 ? mLEU^B 65 76.33 49.16 37.38 76.22 48.17 37.47 74.22 49.35 35.99 74.24 48.26 35.35 75.54 49.99 36.49 76.42 50.41 35.32 3 0 1000.00-999 ?-999 ?-999 ? mVAL^B 66 73.10 50.04 36.21 73.21 50.82 36.83 71.38 50.56 34.43 71.38 51.79 34.56 71.81 49.65 35.58 70.63 49.47 36.57 3 0 1000.00-999 ?-999 ?-999 ? mVAL^B 67 71.02 49.92 33.31 71.03 48.93 33.40 69.23 50.17 31.66 68.93 48.97 31.60 70.65 50.58 32.06 71.54 50.12 30.86 3 0 1000.00-999 ?-999 ?-999 ? mGLU^B 68 68.37 51.15 31.37 68.68 52.06 31.66 67.17 51.35 29.23 67.73 52.40 28.93 67.11 50.90 30.69 65.92 51.55 31.42 2 0 1000.00-999 ?-999 ?-999 ? mASP^B 69 66.66 50.52 28.31 66.33 49.64 28.66 65.34 50.42 26.24 64.55 49.67 26.83 66.60 50.91 26.92 67.88 50.51 26.18 2 0 1000.00-999 ?-999 ?-999 ? mGLU^B 70 65.16 50.88 24.99 65.87 51.54 24.71 64.71 49.91 22.93 65.79 50.35 22.53 64.06 50.49 24.13 63.23 51.71 23.75 2 0 1000.00-999 ?-999 ?-999 ? mVAL^B 71 64.10 48.87 22.36 63.26 48.60 22.82 63.46 48.05 20.25 62.39 47.57 20.69 64.62 48.20 21.19 65.06 46.81 21.52 3 0 1000.00-999 ?-999 ?-999 ? mVAL^B 72 63.63 48.47 19.01 64.52 48.87 18.80 63.06 47.40 16.96 64.14 47.56 16.37 62.61 48.37 18.03 62.31 49.75 17.40 3 0 1000.00-999 ?-999 ?-999 ? mLEU^B 73 62.25 46.38 16.70 61.40 46.37 17.22 61.81 45.51 14.44 60.58 45.57 14.48 62.64 45.38 15.70 62.53 43.98 16.26 3 0 1000.00-999 ?-999 ?-999 ? mLYS^B 74 62.51 45.59 13.32 63.50 45.66 13.43 62.31 44.40 11.19 63.34 44.44 10.52 61.85 45.57 12.05 62.07 46.89 11.36 2 0 1000.00-999 ?-999 ?-999 ? mALA.B 75 61.49 43.36 11.24 60.69 43.48 11.82 61.58 42.30 9.00 60.65 42.94 8.54 61.76 42.15 10.50 60.90 41.05 11.01 2 0 1000.00-999 ?-999 ?-999 ? mPRO.B 76 62.49 41.70 8.23 62.28 41.76 7.25 64.98 41.79 8.44 65.90 41.23 7.86 63.69 41.02 8.74 63.66 39.72 7.95 3 0 1000.00-999 ?-999 ?-999 ? mASP.B 77 65.04 43.06 8.85 64.34 43.31 9.52 66.87 44.63 9.44 68.08 44.86 9.26 66.06 44.00 8.36 65.41 45.10 7.54 2 0 1000.00-999 ?-999 ?-999 ? mSER^B 78 66.26 44.94 10.59 65.34 44.58 10.73 66.50 45.88 12.92 65.32 45.65 13.21 67.00 45.78 11.52 67.13 47.19 10.93 2 0 1000.00-999 ?-999 ?-999 ? mALA^B 79 67.43 46.30 13.78 68.32 46.49 13.36 67.71 47.85 15.67 68.88 48.19 15.44 67.19 46.47 15.19 67.86 45.33 15.95 2 0 1000.00-999 ?-999 ?-999 ? mHIS^B 80 66.87 48.64 16.34 65.96 48.25 16.50 67.23 50.05 18.33 66.17 49.86 18.91 67.28 49.96 16.79 66.40 51.00 16.13 3 0 1000.00-999 ?-999 ?-999 ? mTYR^B 81 68.36 50.28 19.00 69.14 50.43 18.40 68.54 51.79 20.81 69.31 52.51 20.17 68.43 50.32 20.46 69.72 49.63 20.99 3 0 1000.00-999 ?-999 ?-999 ? mSER^B 82 67.82 52.27 21.81 67.22 51.63 22.29 67.79 53.92 23.62 67.06 53.21 24.30 67.96 53.66 22.14 66.98 54.49 21.32 2 0 1000.00-999 ?-999 ?-999 ? mILE^B 83 68.53 54.91 24.10 69.17 55.31 23.45 68.07 56.84 25.42 68.77 57.59 24.75 68.43 55.38 25.47 69.76 55.26 26.22 3 0 1000.00-999 ?-999 ?-999 ? mLYS.B 84 67.00 57.23 26.11 66.46 56.48 26.49 67.64 59.25 27.32 67.89 58.64 28.37 66.69 58.65 26.28 65.23 58.85 26.68 2 0 1000.00-999 ?-999 ?-999 ? mPRO.B 85 68.20 60.43 27.00 67.95 60.82 26.11 68.33 61.69 29.05 67.16 62.04 28.84 69.13 61.08 27.93 69.80 62.17 27.08 3 0 1000.00-999 ?-999 ?-999 ? mSER.B 86 68.94 61.79 30.23 69.78 61.26 30.30 69.48 63.49 31.93 70.53 63.74 31.28 68.39 62.61 31.33 67.63 61.77 32.38 2 0 1000.00-999 ?-999 ?-999 ? mALA.B 87 69.23 63.97 33.14 68.36 63.67 33.53 71.54 64.22 34.02 72.56 64.86 33.74 70.16 64.86 33.84 69.56 65.29 35.21 2 0 1000.00-999 ?-999 ?-999 ? mGLU.B 88 71.55 62.96 34.45 70.63 62.58 34.52 73.38 61.40 33.66 74.62 61.36 33.50 72.76 62.21 34.79 72.42 61.25 35.94 2 0 1000.00-999 ?-999 ?-999 ? mVAL.B 89 72.51 60.74 32.89 71.56 60.94 33.14 72.88 60.48 30.38 71.96 61.25 30.07 72.92 59.82 31.78 71.98 58.54 31.73 3 0 1000.00-999 ?-999 ?-999 ? mALA.B 90 73.86 60.17 29.53 74.60 59.61 29.91 73.01 59.61 27.44 73.04 58.42 27.79 73.81 60.64 28.16 75.18 60.74 27.57 2 0 1000.00-999 ?-999 ?-999 ? mGLY^B 91 72.27 60.07 26.43 72.36 61.05 26.25 72.15 58.67 24.46 73.37 58.89 24.33 71.42 59.18 25.67-999.99-999.99-999.99 1 0 1000.00-999 ?-999 ?-999 ? mGLY^B 92 71.44 57.99 23.58 70.48 57.82 23.80 71.39 56.41 21.73 70.32 56.00 22.18 72.10 57.54 22.39-999.99-999.99-999.99 1 0 1000.00-999 ?-999 ?-999 ? mSER^B 93 71.97 55.92 20.63 72.84 56.36 20.37 72.33 53.95 19.19 73.43 54.35 18.88 71.36 54.84 19.90 70.32 55.38 18.91 2 0 1000.00-999 ?-999 ?-999 ? mLEU^B 94 71.92 52.72 18.97 71.08 52.48 19.46 71.61 51.24 17.07 70.51 50.82 17.45 72.61 51.81 18.09 73.24 50.69 18.90 3 0 1000.00-999 ?-999 ?-999 ? mASP^B 95 71.98 51.24 15.79 72.82 51.75 15.62 72.00 49.37 14.20 73.18 49.52 13.90 71.21 50.57 14.74 71.04 51.51 13.59 2 0 1000.00-999 ?-999 ?-999 ? mMETB 96 71.39 48.20 14.09 70.50 48.16 14.54 71.13 46.75 12.17 69.94 46.41 12.31 72.00 47.08 13.35 72.09 45.82 14.18 2 0 1000.00-999 ?-999 ?-999 ? mTHR^B 97 71.72 46.83 10.99 72.71 46.95 11.02 71.53 45.69 8.85 72.71 45.70 8.60 70.94 46.73 9.77 70.86 48.11 9.10 2 0 1000.00-999 ?-999 ?-999 ? mILE^B 98 70.71 44.80 8.37 69.75 44.91 8.62 71.41 44.38 6.18 70.54 45.10 5.67 71.21 43.75 7.52 70.24 42.55 7.45 3 0 1000.00-999 ?-999 ?-999 ? mGLU^B 99 72.56 44.13 5.60 73.27 43.70 6.16 73.06 43.31 3.36 73.78 42.41 3.79 72.72 44.49 4.22 73.69 45.64 4.12 2 0 1000.00-999 ?-999 ?-999 ? mGLU^B 100 72.50 43.30 2.16 72.00 44.14 1.92 72.82 42.58 -0.16 71.86 42.57 -0.94 72.63 42.15 1.28 71.40 41.27 1.43 2 0 1000.00-999 ?-999 ?-999 ? mPRO^B 101 74.05 42.99 -0.53 74.70 43.04 0.22 74.13 42.21 -2.97 74.08 42.50 -4.18 74.36 43.34 -1.94 75.85 43.72 -1.89 3 0 1000.00-999 ?-999 ?-999 ? mGLU^B 102 74.02 40.96 -2.51 74.23 40.88 -1.53 73.39 38.58 -2.47 73.85 38.56 -1.30 73.64 39.80 -3.37 74.68 39.50 -4.47 2 0 1000.00-999 ?-999 ?-999 ? mPRO.B 103 72.63 37.60 -3.00 72.42 37.69 -3.97 73.38 35.72 -1.54 74.30 35.33 -2.29 72.17 36.47 -2.14 71.37 35.57 -3.10 3 0 1000.00-999 ?-999 ?-999 ? mGLY.B 104 73.40 35.58 -0.22 72.61 35.96 0.26 75.57 35.92 0.84 76.32 35.73 1.83 74.52 34.91 0.45-999.99-999.99-999.99 1 0 1000.00-999 ?-999 ?-999 ? mSER^B 105 75.62 37.03 0.09 75.03 37.02 -0.71 75.89 39.08 1.56 75.25 40.07 1.21 76.51 38.16 0.49 76.93 39.00 -0.73 2 0 1000.00-999 ?-999 ?-999 ? mLEU^B 106 76.06 38.74 2.84 76.67 37.96 2.98 76.37 40.30 4.78 77.52 39.89 5.01 75.40 39.46 3.94 74.66 38.49 4.85 3 0 1000.00-999 ?-999 ?-999 ? mPHE^B 107 75.91 41.47 5.23 74.96 41.68 4.99 75.77 42.84 7.06 74.58 42.82 6.85 76.73 42.35 6.02 77.22 43.56 5.19 3 0 1000.00-999 ?-999 ?-999 ? mVAL^B 108 76.29 43.29 8.19 77.26 43.09 8.31 76.20 45.36 9.42 77.43 45.44 9.68 75.50 44.01 9.16 75.35 43.21 10.44 3 0 1000.00-999 ?-999 ?-999 ? mARG^B 109 75.45 46.44 9.25 74.52 46.27 8.91 75.61 48.08 10.95 74.41 47.99 11.28 75.99 47.75 9.55 75.43 48.76 8.56 2 0 1000.00-999 ?-999 ?-999 ? mPHE^B 110 76.60 48.42 11.79 77.52 48.30 11.43 76.54 50.43 13.16 77.65 50.92 12.83 76.32 48.92 13.14 77.23 48.31 14.21 3 0 1000.00-999 ?-999 ?-999 ? mALA^B 111 75.51 51.16 13.55 74.72 50.63 13.87 75.39 53.14 14.91 74.36 52.88 15.50 75.56 52.60 13.51 74.42 53.12 12.59 2 0 1000.00-999 ?-999 ?-999 ? mTYR^B 112 76.34 53.90 15.44 77.09 54.10 14.81 76.12 55.86 16.87 76.79 56.60 16.13 76.25 54.37 16.82 77.54 54.08 17.57 3 0 1000.00-999 ?-999 ?-999 ? mCYH^B 113 75.34 56.32 17.83 74.88 55.65 18.40 74.97 58.06 19.44 74.57 57.17 20.21 75.20 57.72 17.97 74.06 58.20 17.08 2 0 1000.00-999 ?-999 ?-999 ? mTHR^B 114 75.26 59.32 19.82 75.50 59.93 19.06 74.52 61.10 21.19 74.84 61.95 20.38 75.24 59.77 21.20 76.68 59.99 21.68 2 0 1000.00-999 ?-999 ?-999 ? mARG^B 115 73.54 61.28 22.09 73.33 60.45 22.61 72.94 63.06 23.76 72.92 62.23 24.70 72.86 62.59 22.28 71.39 62.53 21.78 2 0 1000.00-999 ?-999 ?-999 ? mTYR.B 116 73.03 64.38 23.97 73.13 64.91 23.13 71.69 65.78 25.55 71.03 66.13 24.57 72.99 64.94 25.33 74.29 65.74 25.57 3 0 1000.00-999 ?-999 ?-999 ? mLEU.B 117 71.28 66.03 26.80 71.76 65.52 27.51 70.66 68.38 26.50 69.96 69.03 25.71 70.18 67.01 27.03 69.75 67.10 28.51 3 0 1000.00-999 ?-999 ?-999 ? mGLN.B 118 71.89 68.75 26.89 72.30 68.10 27.54 73.37 69.77 25.12 73.56 68.65 24.67 72.59 69.97 26.45 73.53 70.51 27.58 2 0 1000.00-999 ?-999 ?-999 ? mPRO.B 119 73.81 70.87 24.48 73.64 71.76 24.90 76.00 70.80 23.37 76.66 71.27 22.44 74.49 70.66 23.21 74.00 71.85 22.39 3 0 1000.00-999 ?-999 ?-999 ? mASP.B 122 79.59 73.17 17.41 78.87 73.86 17.44 80.00 70.77 17.35 79.25 70.41 18.26 80.63 72.15 17.36 81.58 72.28 18.56 2 0 1000.00-999 ?-999 ?-999 ? mGLU.B 123 80.30 70.01 16.30 80.77 70.51 15.57 81.14 67.76 16.72 82.31 68.15 16.50 79.96 68.58 16.21 79.63 68.20 14.76 2 0 1000.00-999 ?-999 ?-999 ? mLEU.B 124 80.89 66.64 17.42 79.94 66.32 17.39 82.31 64.58 17.75 81.44 63.72 17.68 81.99 66.00 18.17 81.79 66.06 19.69 3 0 1000.00-999 ?-999 ?-999 ? mPRO.B 125 83.59 64.31 17.49 84.22 65.09 17.55 84.19 61.98 18.36 84.58 62.44 19.43 83.96 62.94 17.14 85.24 63.15 16.32 3 0 1000.00-999 ?-999 ?-999 ? mTYR.B 126 83.90 60.69 18.19 83.34 60.51 17.38 85.87 59.54 19.06 86.48 59.96 18.03 84.36 59.64 19.13 83.82 58.28 18.73 3 0 1000.00-999 ?-999 ?-999 ? mASP~B 127 86.48 59.03 20.13 85.90 58.85 20.92 88.15 57.32 19.78 87.19 56.52 19.76 87.90 58.78 20.09 88.55 59.19 21.38 2 0 1000.00-999 ?-999 ?-999 ? mALA~B 128 89.41 56.95 19.53 90.09 57.65 19.75 89.60 54.47 19.99 89.34 53.31 19.58 89.73 55.61 18.99 91.07 55.60 18.35 2 0 1000.00-999 ?-999 ?-999 ? mPHE~B 129 89.72 54.76 21.29 90.07 55.68 21.49 87.90 53.36 22.18 87.57 52.15 22.26 89.35 53.78 22.32 89.56 54.33 23.71 3 0 1000.00-999 ?-999 ?-999 ? mVAL~B 130 87.02 54.33 21.97 87.38 55.26 21.92 85.46 53.26 20.51 84.83 52.23 20.44 85.62 53.99 21.83 84.68 55.23 21.95 3 0 1000.00-999 ?-999 ?-999 ? mLYS~B 131 86.04 53.78 19.44 86.58 54.60 19.58 86.35 51.64 18.27 85.72 50.69 17.83 85.81 53.07 18.17 86.41 53.79 17.01 2 0 1000.00-999 ?-999 ?-999 ? mGLN~B 132 87.50 51.47 18.91 87.91 52.31 19.28 87.09 49.28 19.83 86.71 48.20 19.36 88.08 50.16 19.05 89.42 50.26 19.75 2 0 1000.00-999 ?-999 ?-999 ? mALA~B 133 86.61 49.75 20.96 86.97 50.64 21.25 84.32 48.60 20.92 83.76 47.53 21.14 85.61 48.94 21.70 85.26 49.56 23.05 2 0 1000.00-999 ?-999 ?-999 ? mTYR~B 134 83.86 49.49 20.03 84.38 50.33 19.96 82.89 48.11 18.20 82.13 47.15 18.09 82.67 49.21 19.25 82.21 50.49 18.59 3 0 1000.00-999 ?-999 ?-999 ? mILE~B 135 83.93 48.27 17.41 84.38 49.16 17.50 84.50 45.95 17.25 84.02 44.95 16.79 84.36 47.26 16.52 85.71 47.65 15.87 3 0 1000.00-999 ?-999 ?-999 ? mALA~B 136 85.18 45.90 18.36 85.57 46.77 18.67 83.90 43.97 19.30 83.66 42.83 18.99 85.28 44.59 19.04 86.12 44.67 20.35 2 0 1000.00-999 ?-999 ?-999 ? mMETB 137 82.99 44.74 19.87 83.27 45.68 20.06 80.90 43.80 18.98 80.25 42.76 19.01 81.71 44.20 20.19 80.95 45.23 20.95 2 0 1000.00-999 ?-999 ?-999 ? mASP~B 138 80.91 44.62 17.92 81.46 45.45 18.03 80.65 42.94 16.08 79.85 42.11 15.61 80.16 44.27 16.69 80.26 45.38 15.65 2 0 1000.00-999 ?-999 ?-999 ? mVAL~B 139 81.96 42.75 16.10 82.49 43.53 16.45 82.21 40.33 16.53 81.75 39.32 16.02 82.57 41.52 15.64 84.11 41.65 15.42 3 0 1000.00-999 ?-999 ?-999 ? mGLU~B 140 82.36 40.44 17.85 82.81 41.28 18.14 80.42 39.06 18.55 80.04 37.89 18.53 81.90 39.37 18.74 82.22 39.66 20.20 2 0 1000.00-999 ?-999 ?-999 ? mTHR~B 141 79.61 40.09 18.33 80.03 41.00 18.31 77.98 38.92 16.93 77.23 37.94 17.03 78.21 39.84 18.15 77.44 41.12 17.96 2 0 1000.00-999 ?-999 ?-999 ? mILE~B 142 78.60 39.24 15.80 79.21 40.02 15.84 78.97 37.09 14.83 78.40 36.10 14.43 78.36 38.45 14.62 78.93 39.12 13.32 3 0 1000.00-999 ?-999 ?-999 ? mALA~B 143 80.11 37.00 15.50 80.52 37.87 15.78 79.69 34.81 16.58 79.55 33.64 16.33 80.66 35.67 15.75 82.01 35.74 16.43 2 0 1000.00-999 ?-999 ?-999 ? mTHR~B 144 79.06 35.40 17.58 79.28 36.37 17.70 76.90 34.18 17.59 76.47 33.02 17.71 78.13 34.64 18.41 77.68 35.50 19.57 2 0 1000.00-999 ?-999 ?-999 ? mILE~B 145 76.35 35.07 16.77 76.78 35.97 16.76 75.61 33.59 15.02 74.88 32.64 14.85 75.22 34.72 15.96 74.71 35.90 15.16 3 0 1000.00-999 ?-999 ?-999 ? mARG~B 146 76.79 33.72 14.41 77.24 34.59 14.59 77.52 31.35 14.33 77.49 30.28 13.76 77.34 32.66 13.55 78.68 33.10 12.90 2 0 1000.00-999 ?-999 ?-999 ? mASP~B 147 77.70 31.41 15.63 77.62 32.30 16.07 76.68 29.53 16.82 76.57 28.30 16.87 77.99 30.17 16.29 79.13 30.38 17.28 2 0 1000.00-999 ?-999 ?-999 ? mARG~B 148 75.68 30.35 17.16 75.89 31.33 17.09 73.46 29.43 16.42 72.65 28.55 16.57 74.40 29.82 17.58 73.69 30.77 18.55 2 0 1000.00-999 ?-999 ?-999 ? mPHE~B 149 73.56 30.11 15.27 74.37 30.70 15.24 73.32 29.61 12.87 72.71 29.13 11.91 72.59 30.00 14.17 71.75 31.32 13.97 3 0 1000.00-999 ?-999 ?-999 ?