Welcome to Sprite!
Sprite is a protein structural motif database searching program.
Users upload a pdb file of a query protein structure, and Sprite compares the coordinates to a database of 3D motifs.
In favorable cases, comparing 3D motifs may reveal biologically interesting similarities that are not detectable by comparing sequences or folds.

Notes: 
1. Please ensure that the query is a PDB formatted file.
2. The program typically takes 5-10 minutes to complete depending on the size of your protein. Thank you for your patience.

Upload file to submit for Sprite search:



* PDB input files will not be used for purposes other than the search and will be deleted upon search completion.

Example and test run:
Click HERE to run an example for 3tu8
Click HERE to view the results of a run of 3tu8
 
Primary References:
1. Spriggs RV, Artymiuk PJ, Willett P. (2003) Searching for patterns of amino acids in 3D protein structures. J Chem Inf Comput Sci. Mar-Apr;43(2):412-21. (Citation for ASSAM search)
2. Artymiuk PJ, Poirrette AR, Grindley HM, Rice DW, Willett P. (1994) A graph-theoretic approach to the identification of three-dimensional patterns of amino acid side-chains in protein structures. J Mol Biol. Oct 21;243(2):327-44.

Email: info@mfrlab.org