Sequence Similarity : Non-homologous sequences (<30%) SEQUENCE SIMILARITY (%) 1knzA 1knzB 1mhmA 1mhmB 2vbkA 3bvfA 3hm4A 3hm4B 3zq4A 4ksiA 4p78A 4y9vA 5a9aA 5ax6A 5c69A 5ea4F 5u1aA 5u1aC 5u1aF 1knzA 100 93 17 0 76 10 2 8 0 0 0 0 0 0 0 0 3 3 3 1knzB 93 100 54 0 59 20 24 23 0 0 0 0 0 41 0 40 6 6 6 1mhmA 22 49 100 0 90 0 77 77 95 90 0 49 83 0 65 61 0 0 0 1mhmB 0 0 9 100 0 0 4 3 0 0 0 0 0 0 0 0 0 0 0 2vbkA 0 0 87 0 100 0 50 0 89 13 0 100 51 100 0 0 0 0 0 3bvfA 3 22 0 0 0 100 0 0 0 45 0 0 0 0 0 0 96 95 95 3hm4A 2 21 84 0 86 0 100 98 55 75 0 0 0 0 0 0 0 0 0 3hm4B 10 25 33 0 87 0 98 100 69 76 0 0 0 0 0 0 0 0 0 3zq4A 31 0 100 0 90 0 63 71 100 100 0 0 0 59 0 0 0 0 0 4ksiA 50 67 100 0 98 0 56 34 50 100 0 0 0 0 0 53 0 0 0 4p78A 0 0 0 0 28 0 39 39 4 0 100 0 0 0 0 0 0 0 0 4y9vA 32 29 81 0 88 0 0 35 87 79 0 100 0 100 0 0 0 0 0 5a9aA 12 15 48 0 75 0 58 53 60 0 0 0 100 0 0 0 0 0 0 5ax6A 17 52 83 0 66 0 44 43 78 0 0 0 0 100 0 0 0 0 0 5c69A 79 0 70 0 70 0 0 0 26 82 0 100 0 0 100 99 0 0 0 5ea4F 0 57 72 0 71 0 25 85 0 72 0 0 0 0 99 100 0 0 0 5u1aA 3 0 0 0 0 96 0 23 8 0 0 0 0 0 0 0 100 99 99 5u1aC 3 0 0 0 0 95 0 23 0 0 0 0 0 0 0 0 99 100 99 5u1aF 3 0 0 0 0 95 0 0 8 48 0 0 0 0 0 0 99 99 100 FOLD SIMILARITY (Z-SCORE) 1knzA 1knzB 1mhmA 1mhmB 2vbkA 3bvfA 3hm4A 3hm4B 3zq4A 4ksiA 4p78A 4y9vA 5a9aA 5ax6A 5c69A 5ea4F 5u1aA 5u1aC 5u1aF 1knzA 20.3 9.4 0 0 0 1.9 1.3 0.9 3.4 0 0 0 0 0 0 0 2.6 2.6 2.5 1knzB 9.4 20.2 0.1 0 0 1.6 1.7 1.4 2.7 0 0 0 0 1.6 0 1.7 2.2 2.2 2.1 1mhmA 0 0 44.9 0 0 0 1.1 1.1 1.6 1.6 0 1.4 0.5 0 0.3 0.4 0 0 0 1mhmB 0 0 0.4 10.7 0 0 0 0 0 0 0 0 0 0.6 0 0 0 0 0 2vbkA 0 0 0 0 69.5 0 0 0 0 0 0 6.7 0 2.8 0 0 0 0 0 3bvfA 2.4 1.7 0 0 0 31.7 0 0 0 0 0 0 0 0 0 0 28.6 28.4 28.6 3hm4A 1.3 1.1 0.1 0 0 0 34.2 29.9 0 0.7 0 0 0 0 0 0 0 0 0 3hm4B 0.6 0.9 0 0 0 0 29.9 33.6 1.1 0.7 0 0 0 0 0 0 0 0 0 3zq4A 0 2.7 2.9 0 0 0 2.3 0 68 0.6 0 0 0 0.7 0 0 0 0 0 4ksiA 0 0 0.8 0 0 0 0.1 0 0 66.7 0 0 0 0 0 0.8 0 0 0 4p78A 0 0 0 0 0.6 0 0.1 0 0 0 20.1 0 0 0 0 0 0 0 0 4y9vA 0 0 0 0 17 0 0 0 0 0 0 66.5 0 1.4 0 0 0 0 0 5a9aA 0 0 0 0 0 0 0 0 0 0 0 0 38 0 0 0 0 0 0 5ax6A 0 0.9 0 0 0 0 0 0.6 0.2 0 0 0 0 43.6 0 0 0 0 0 5c69A 0 0 0 0 0 0 0 0 0 0.6 0 0 0 0 55.9 52.4 0 0 0 5ea4F 0 1.7 0 0 0 0 0 0 0 1 0 0 0 0 52.4 56.3 0 0 0 5u1aA 2.5 0 0 0 0 28.6 0 0.7 1.1 0 0 0 0 0 0 0 32 30.1 29.9 5u1aC 2.6 0 0 0 0 28.4 0 0.7 0 0 0 0 0 0 0 0 30.1 31.8 30 5u1aF 2.2 0 0 0 0 28.6 0 0 1.1 0 0 0 0 0 0 0 29.9 30 31.8