DRUG BINDING INTERFACES MAPPED TO 'TPF'
List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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All hits from Homo Sapiens
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Only hits with patterns containing 3-12 residues
DrReposER ID
PDB
Ligand
Organism
Macromolecule
Pfam
Res.
Interface
HETATM
1EA1_A_TPFA470
1ea1
TPF
DB00196(Fluconazole)
Mycobacteriumtuberculosis
CYTOCHROME P45051-LIKE RV0764C
PF00067(p450)
8
TYR A 76PHE A 78MET A 79ARG A 96LEU A 100PHE A 255THR A 260LEU A 321
TPF A 470
2IJ7_A_TPFA2472
2ij7
TPF
DB00196(Fluconazole)
Mycobacteriumtuberculosis
CYTOCHROME P450 121
PF00067(p450)
11
THR A 77VAL A 78ASN A 85MET A 86PHE A 168THR A 229ALA A 233SER A 237PHE A 280GLN A 385ARG A 386
TPF A2472
2IJ7_B_TPFB2470
2ij7
TPF
DB00196(Fluconazole)
Mycobacteriumtuberculosis
CYTOCHROME P450 121
no annotation
9
THR B 77VAL B 78ASN B 85MET B 86PHE B 168THR B 229ALA B 233GLN B 385ARG B 386
TPF B2470
2IJ7_C_TPFC2471
2ij7
TPF
DB00196(Fluconazole)
Mycobacteriumtuberculosis
CYTOCHROME P450 121
no annotation
8
THR C 77VAL C 78VAL C 83ASN C 85PHE C 168ALA C 233GLN C 385ARG C 386
TPF C2471
2IJ7_D_TPFD2473
2ij7
TPF
DB00196(Fluconazole)
Mycobacteriumtuberculosis
CYTOCHROME P450 121
no annotation
10
THR D 77VAL D 78ASN D 85PHE D 168THR D 229ALA D 233SER D 237PHE D 280GLN D 385ARG D 386
TPF D2473
2IJ7_F_TPFF2474
2ij7
TPF
DB00196(Fluconazole)
Mycobacteriumtuberculosis
CYTOCHROME P450 121
no annotation
10
THR F 77VAL F 78ASN F 85MET F 86PHE F 168THR F 229ALA F 233SER F 237GLN F 385ARG F 386
TPF F2474
2WUZ_A_TPFA1460
2wuz
TPF
DB00196(Fluconazole)
Trypanosomacruzi
LANOSTEROL14-ALPHA-DEMETHYLASE, PUTATIVE
PF00067(p450)
10
TYR A 103MET A 106PHE A 110TYR A 116ALA A 287ALA A 291THR A 295LEU A 356MET A 460VAL A 461
TPF A1460
2WUZ_B_TPFB1460
2wuz
TPF
DB00196(Fluconazole)
Trypanosomacruzi
LANOSTEROL14-ALPHA-DEMETHYLASE, PUTATIVE
no annotation
10
TYR B 103MET B 106PHE B 110TYR B 116ALA B 287ALA B 291THR B 295LEU B 356MET B 460VAL B 461
TPF B1460
2WV2_A_TPFA1
2wv2
TPF
DB00196(Fluconazole)
Trypanosomabrucei
LANOSTEROL14-ALPHA-DEMETHYLASE
PF00067(p450)
9
TYR A 103MET A 106PHE A 110TYR A 116ALA A 287ALA A 291THR A 295LEU A 356MET A 460
TPF A 1
2WX2_A_TPFA1460
2wx2
TPF
DB00196(Fluconazole)
Trypanosomacruzi
LANOSTEROL14-ALPHA-DEMETHYLASE
PF00067(p450)
7
MET A 106PHE A 110TYR A 116ALA A 287ALA A 291THR A 295LEU A 356
TPF A1460
2WX2_B_TPFB1460
2wx2
TPF
DB00196(Fluconazole)
Trypanosomacruzi
LANOSTEROL14-ALPHA-DEMETHYLASE
no annotation
8
TYR B 103MET B 106PHE B 110TYR B 116ALA B 287ALA B 291THR B 295LEU B 356
TPF B1460
3KHM_A_TPFA501
3khm
TPF
DB00196(Fluconazole)
Trypanosomacruzi
STEROL 14ALPHA-DEMETHYLASE
PF00067(p450)
8
TYR A 103MET A 106PHE A 110TYR A 116ALA A 287ALA A 291THR A 295LEU A 356
TPF A 501
3L4D_A_TPFA490
3l4d
TPF
DB00196(Fluconazole)
Leishmaniainfantum
STEROL 14-ALPHADEMETHYLASE
PF00067(p450)
8
TYR A 102PHE A 109TYR A 115ALA A 286ALA A 290THR A 294LEU A 355MET A 459
TPF A 490
3L4D_B_TPFB490
3l4d
TPF
DB00196(Fluconazole)
Leishmaniainfantum
STEROL 14-ALPHADEMETHYLASE
no annotation
9
TYR B 102MET B 105PHE B 109TYR B 115ALA B 286ALA B 290THR B 294LEU B 355MET B 459
TPF B 490
3L4D_C_TPFC490
3l4d
TPF
DB00196(Fluconazole)
Leishmaniainfantum
STEROL 14-ALPHADEMETHYLASE
no annotation
9
TYR C 102MET C 105PHE C 109TYR C 115ALA C 286ALA C 290THR C 294LEU C 355MET C 459
TPF C 490
3L4D_D_TPFD490
3l4d
TPF
DB00196(Fluconazole)
Leishmaniainfantum
STEROL 14-ALPHADEMETHYLASE
no annotation
8
MET D 105PHE D 109TYR D 115ALA D 286ALA D 290THR D 294LEU D 355MET D 459
TPF D 490
4WMZ_A_TPFA602
4wmz
TPF
DB00196(Fluconazole)
Saccharomycescerevisiae
LANOSTEROL 14-ALPHADEMETHYLASE
PF00067(p450)
9
TYR A 126PHE A 134ILE A 139TYR A 140PHE A 236GLY A 314THR A 318LEU A 380MET A 509
TPF A 602
4ZDZ_A_TPFA602
4zdz
TPF
DB00196(Fluconazole)
Saccharomycescerevisiae
LANOSTEROL 14-ALPHADEMETHYLASE
PF00067(p450)
7
PHE A 134ILE A 139PHE A 236GLY A 314THR A 318LEU A 380MET A 509
TPF A 602
4ZE3_A_TPFA602
4ze3
TPF
DB00196(Fluconazole)
Saccharomycescerevisiae
LANOSTEROL 14-ALPHADEMETHYLASE
PF00067(p450)
7
TYR A 126PHE A 134ILE A 139PHE A 236GLY A 314THR A 318LEU A 380
TPF A 602
5ESE_A_TPFA602
5ese
TPF
DB00196(Fluconazole)
Saccharomycescerevisiae
LANOSTEROL 14-ALPHADEMETHYLASE
PF00067(p450)
8
TYR A 126LEU A 129PHE A 134ILE A 139PHE A 236GLY A 314THR A 318LEU A 380
TPF A 602
5ESF_A_TPFA602
5esf
TPF
DB00196(Fluconazole)
Saccharomycescerevisiae
LANOSTEROL 14-ALPHADEMETHYLASE
PF00067(p450)
8
TYR A 126PHE A 134ILE A 139TYR A 140PHE A 236GLY A 314THR A 318LEU A 380
TPF A 602
5ESJ_A_TPFA602
5esj
TPF
DB00196(Fluconazole)
Saccharomycescerevisiae
LANOSTEROL 14-ALPHADEMETHYLASE
PF00067(p450)
8
TYR A 126PHE A 134ILE A 139PHE A 236GLY A 314THR A 318LEU A 380MET A 509
TPF A 602
5ESM_A_TPFA602
5esm
TPF
DB00196(Fluconazole)
Saccharomycescerevisiae
LANOSTEROL 14-ALPHADEMETHYLASE
PF00067(p450)
7
TYR A 126PHE A 134ILE A 139PHE A 236GLY A 314THR A 318LEU A 380
TPF A 602
6AY4_A_TPFA506
6ay4
TPF
DB00196(Fluconazole)
Naegleriafowleri
CYP51, STEROL14ALPHA-DEMETHYLASE
no annotation
10
TYR A 107MET A 110PHE A 114TYR A 120ALA A 289PHE A 292ALA A 293THR A 297LEU A 358CYS A 430
TPF A 506
6MA7_A_TPFA602
6ma7
TPF
DB00196(Fluconazole)
Homo sapiens
CYTOCHROME P450 3A4
PF00067(p450)
7
ARG A 105SER A 119ARG A 212ALA A 305THR A 309ILE A 369ALA A 370
TPF A 602
[["1EA1_A_TPFA470","1ea1","TPF","DB00196(Fluconazole)","Mycobacterium tuberculosis","CYTOCHROME P450 51-LIKE RV0764C","PF00067(p450)",8,"TYR A 76;PHE A 78;MET A 79;ARG A 96;LEU A 100;PHE A 255;THR A 260;LEU A 321","TPF A 470\r"],["2IJ7_A_TPFA2472","2ij7","TPF","DB00196(Fluconazole)","Mycobacterium tuberculosis","CYTOCHROME P450 121","PF00067(p450)",11,"THR A 77;VAL A 78;ASN A 85;MET A 86;PHE A 168;THR A 229;ALA A 233;SER A 237;PHE A 280;GLN A 385;ARG A 386","TPF A2472\r"],["2IJ7_B_TPFB2470","2ij7","TPF","DB00196(Fluconazole)","Mycobacterium tuberculosis","CYTOCHROME P450 121","no annotation",9,"THR B 77;VAL B 78;ASN B 85;MET B 86;PHE B 168;THR B 229;ALA B 233;GLN B 385;ARG B 386","TPF B2470\r"],["2IJ7_C_TPFC2471","2ij7","TPF","DB00196(Fluconazole)","Mycobacterium tuberculosis","CYTOCHROME P450 121","no annotation",8,"THR C 77;VAL C 78;VAL C 83;ASN C 85;PHE C 168;ALA C 233;GLN C 385;ARG C 386","TPF C2471\r"],["2IJ7_D_TPFD2473","2ij7","TPF","DB00196(Fluconazole)","Mycobacterium tuberculosis","CYTOCHROME P450 121","no annotation",10,"THR D 77;VAL D 78;ASN D 85;PHE D 168;THR D 229;ALA D 233;SER D 237;PHE D 280;GLN D 385;ARG D 386","TPF D2473\r"],["2IJ7_F_TPFF2474","2ij7","TPF","DB00196(Fluconazole)","Mycobacterium tuberculosis","CYTOCHROME P450 121","no annotation",10,"THR F 77;VAL F 78;ASN F 85;MET F 86;PHE F 168;THR F 229;ALA F 233;SER F 237;GLN F 385;ARG F 386","TPF F2474\r"],["2WUZ_A_TPFA1460","2wuz","TPF","DB00196(Fluconazole)","Trypanosoma cruzi","LANOSTEROL 14-ALPHA-DEMETHYLASE, PUTATIVE","PF00067(p450)",10,"TYR A 103;MET A 106;PHE A 110;TYR A 116;ALA A 287;ALA A 291;THR A 295;LEU A 356;MET A 460;VAL A 461","TPF A1460\r"],["2WUZ_B_TPFB1460","2wuz","TPF","DB00196(Fluconazole)","Trypanosoma cruzi","LANOSTEROL 14-ALPHA-DEMETHYLASE, PUTATIVE","no annotation",10,"TYR B 103;MET B 106;PHE B 110;TYR B 116;ALA B 287;ALA B 291;THR B 295;LEU B 356;MET B 460;VAL B 461","TPF B1460\r"],["2WV2_A_TPFA1","2wv2","TPF","DB00196(Fluconazole)","Trypanosoma brucei","LANOSTEROL 14-ALPHA-DEMETHYLASE","PF00067(p450)",9,"TYR A 103;MET A 106;PHE A 110;TYR A 116;ALA A 287;ALA A 291;THR A 295;LEU A 356;MET A 460","TPF A 1\r"],["2WX2_A_TPFA1460","2wx2","TPF","DB00196(Fluconazole)","Trypanosoma cruzi","LANOSTEROL 14-ALPHA-DEMETHYLASE","PF00067(p450)",7,"MET A 106;PHE A 110;TYR A 116;ALA A 287;ALA A 291;THR A 295;LEU A 356","TPF A1460\r"],["2WX2_B_TPFB1460","2wx2","TPF","DB00196(Fluconazole)","Trypanosoma cruzi","LANOSTEROL 14-ALPHA-DEMETHYLASE","no annotation",8,"TYR B 103;MET B 106;PHE B 110;TYR B 116;ALA B 287;ALA B 291;THR B 295;LEU B 356","TPF B1460\r"],["3KHM_A_TPFA501","3khm","TPF","DB00196(Fluconazole)","Trypanosoma cruzi","STEROL 14 ALPHA-DEMETHYLASE","PF00067(p450)",8,"TYR A 103;MET A 106;PHE A 110;TYR A 116;ALA A 287;ALA A 291;THR A 295;LEU A 356","TPF A 501\r"],["3L4D_A_TPFA490","3l4d","TPF","DB00196(Fluconazole)","Leishmania infantum","STEROL 14-ALPHA DEMETHYLASE","PF00067(p450)",8,"TYR A 102;PHE A 109;TYR A 115;ALA A 286;ALA A 290;THR A 294;LEU A 355;MET A 459","TPF A 490\r"],["3L4D_B_TPFB490","3l4d","TPF","DB00196(Fluconazole)","Leishmania infantum","STEROL 14-ALPHA DEMETHYLASE","no annotation",9,"TYR B 102;MET B 105;PHE B 109;TYR B 115;ALA B 286;ALA B 290;THR B 294;LEU B 355;MET B 459","TPF B 490\r"],["3L4D_C_TPFC490","3l4d","TPF","DB00196(Fluconazole)","Leishmania infantum","STEROL 14-ALPHA DEMETHYLASE","no annotation",9,"TYR C 102;MET C 105;PHE C 109;TYR C 115;ALA C 286;ALA C 290;THR C 294;LEU C 355;MET C 459","TPF C 490\r"],["3L4D_D_TPFD490","3l4d","TPF","DB00196(Fluconazole)","Leishmania infantum","STEROL 14-ALPHA DEMETHYLASE","no annotation",8,"MET D 105;PHE D 109;TYR D 115;ALA D 286;ALA D 290;THR D 294;LEU D 355;MET D 459","TPF D 490\r"],["4WMZ_A_TPFA602","4wmz","TPF","DB00196(Fluconazole)","Saccharomyces cerevisiae","LANOSTEROL 14-ALPHA DEMETHYLASE","PF00067(p450)",9,"TYR A 126;PHE A 134;ILE A 139;TYR A 140;PHE A 236;GLY A 314;THR A 318;LEU A 380;MET A 509","TPF A 602\r"],["4ZDZ_A_TPFA602","4zdz","TPF","DB00196(Fluconazole)","Saccharomyces cerevisiae","LANOSTEROL 14-ALPHA DEMETHYLASE","PF00067(p450)",7,"PHE A 134;ILE A 139;PHE A 236;GLY A 314;THR A 318;LEU A 380;MET A 509","TPF A 602\r"],["4ZE3_A_TPFA602","4ze3","TPF","DB00196(Fluconazole)","Saccharomyces cerevisiae","LANOSTEROL 14-ALPHA DEMETHYLASE","PF00067(p450)",7,"TYR A 126;PHE A 134;ILE A 139;PHE A 236;GLY A 314;THR A 318;LEU A 380","TPF A 602\r"],["5ESE_A_TPFA602","5ese","TPF","DB00196(Fluconazole)","Saccharomyces cerevisiae","LANOSTEROL 14-ALPHA DEMETHYLASE","PF00067(p450)",8,"TYR A 126;LEU A 129;PHE A 134;ILE A 139;PHE A 236;GLY A 314;THR A 318;LEU A 380","TPF A 602\r"],["5ESF_A_TPFA602","5esf","TPF","DB00196(Fluconazole)","Saccharomyces cerevisiae","LANOSTEROL 14-ALPHA DEMETHYLASE","PF00067(p450)",8,"TYR A 126;PHE A 134;ILE A 139;TYR A 140;PHE A 236;GLY A 314;THR A 318;LEU A 380","TPF A 602\r"],["5ESJ_A_TPFA602","5esj","TPF","DB00196(Fluconazole)","Saccharomyces cerevisiae","LANOSTEROL 14-ALPHA DEMETHYLASE","PF00067(p450)",8,"TYR A 126;PHE A 134;ILE A 139;PHE A 236;GLY A 314;THR A 318;LEU A 380;MET A 509","TPF A 602\r"],["5ESM_A_TPFA602","5esm","TPF","DB00196(Fluconazole)","Saccharomyces cerevisiae","LANOSTEROL 14-ALPHA DEMETHYLASE","PF00067(p450)",7,"TYR A 126;PHE A 134;ILE A 139;PHE A 236;GLY A 314;THR A 318;LEU A 380","TPF A 602\r"],["6AY4_A_TPFA506","6ay4","TPF","DB00196(Fluconazole)","Naegleria fowleri","CYP51, STEROL 14ALPHA-DEMETHYLASE","no annotation",10,"TYR A 107;MET A 110;PHE A 114;TYR A 120;ALA A 289;PHE A 292;ALA A 293;THR A 297;LEU A 358;CYS A 430","TPF A 506\r"],["6MA7_A_TPFA602","6ma7","TPF","DB00196(Fluconazole)","Homo sapiens","CYTOCHROME P450 3A4","PF00067(p450)",7,"ARG A 105;SER A 119;ARG A 212;ALA A 305;THR A 309;ILE A 369;ALA A 370","TPF A 602\r"]]