DRUG BINDING INTERFACES MAPPED TO 'TOP'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)

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DrReposER ID	PDB	Ligand	Organism	Macromolecule	Pfam	Res.	Interface	HETATM
1DG5_A_TOPA201	1dg5	TOP DB00440 (Trimethoprim)	Mycobacterium tuberculosis	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	11	ILE A 5 TRP A 6 ALA A 7 ILE A 20 ASP A 27 PHE A 31 SER A 49 LEU A 50 PRO A 51 ILE A 94 TYR A 100	TOP A 201
1DYR_A_TOPA407	1dyr	TOP DB00440 (Trimethoprim)	Pneumocystis carinii	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	11	ILE A 10 ALA A 12 LEU A 25 GLU A 32 ILE A 33 PHE A 36 ILE A 65 PRO A 66 ILE A 123 TYR A 129 THR A 144	TOP A 407
2BFM_A_TOPA1290	2bfm	TOP DB00440 (Trimethoprim)	Leishmania major	PTERIDINE REDUCTASE 1	PF00106 (adh_short) PF13561 (adh_short_C2) no annotation	9	PHE A 113 ASP A 181 LEU A 188 TYR A 194 LEU A 226 LEU A 229 HIS A 241 TYR A 283 ARG D 287	TOP A1290
2BFM_B_TOPB1290	2bfm	TOP DB00440 (Trimethoprim)	Leishmania major	PTERIDINE REDUCTASE 1	no annotation	9	PHE B 113 ASP B 181 LEU B 188 TYR B 191 TYR B 194 LEU B 226 LEU B 229 HIS B 241 ARG C 287	TOP B1290
2W3A_A_TOPA1190	2w3a	TOP DB00440 (Trimethoprim)	Homo sapiens	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	11	ILE A 7 ALA A 9 GLU A 30 PHE A 31 PHE A 34 THR A 56 ILE A 60 PRO A 61 VAL A 115 TYR A 121 THR A 136	TOP A1190
2W3A_B_TOPB1189	2w3a	TOP DB00440 (Trimethoprim)	Homo sapiens	DIHYDROFOLATE REDUCTASE	no annotation	10	ILE B 7 ALA B 9 GLU B 30 PHE B 31 PHE B 34 THR B 56 ILE B 60 LEU B 67 TYR B 121 THR B 136	TOP B1189
2W3V_A_TOPA1169	2w3v	TOP DB00440 (Trimethoprim)	Mycobacterium avium	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	12	VAL A 9 TRP A 10 ALA A 11 ILE A 24 ASP A 31 LEU A 32 PHE A 35 SER A 53 LEU A 54 ILE A 102 TYR A 108 THR A 121	TOP A1169
2W9G_A_TOPA1159	2w9g	TOP DB00440 (Trimethoprim)	Staphylococcus aureus	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	10	LEU A 5 ALA A 7 LEU A 20 ASP A 27 LEU A 28 VAL A 31 SER A 49 ILE A 50 PHE A 92 THR A 111	TOP A1159
2W9H_A_TOPA1160	2w9h	TOP DB00440 (Trimethoprim)	Staphylococcus aureus	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	10	LEU A 5 ALA A 7 LEU A 20 ASP A 27 LEU A 28 VAL A 31 SER A 49 ILE A 50 PHE A 92 THR A 111	TOP A1160
2W9S_A_TOPA1160	2w9s	TOP DB00440 (Trimethoprim)	Staphylococcus aureus	DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003	PF00186 (DHFR_1)	11	ILE A 5 ALA A 7 LEU A 20 ASP A 27 LEU A 28 ILE A 31 SER A 49 ILE A 50 PHE A 92 TYR A 98 THR A 111	TOP A1160
2W9S_B_TOPB1160	2w9s	TOP DB00440 (Trimethoprim)	Staphylococcus aureus	DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003	no annotation	11	ILE B 5 ALA B 7 LEU B 20 ASP B 27 LEU B 28 ILE B 31 SER B 49 ILE B 50 PHE B 92 TYR B 98 THR B 111	TOP B1160
2W9S_C_TOPC1160	2w9s	TOP DB00440 (Trimethoprim)	Staphylococcus aureus	DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003	no annotation	10	ILE C 5 ALA C 7 LEU C 20 ASP C 27 ILE C 31 SER C 49 ILE C 50 PHE C 92 TYR C 98 THR C 111	TOP C1160
2W9S_D_TOPD1158	2w9s	TOP DB00440 (Trimethoprim)	Staphylococcus aureus	DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003	no annotation	10	ILE D 5 ALA D 7 LEU D 20 ASP D 27 LEU D 28 ILE D 31 SER D 49 PHE D 92 TYR D 98 THR D 111	TOP D1158
2W9S_E_TOPE1160	2w9s	TOP DB00440 (Trimethoprim)	Staphylococcus aureus	DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003	no annotation	8	ILE E 5 ALA E 7 LEU E 20 ASP E 27 ILE E 31 PHE E 92 TYR E 98 THR E 111	TOP E1160
2W9S_F_TOPF1159	2w9s	TOP DB00440 (Trimethoprim)	Staphylococcus aureus	DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003	no annotation	10	ILE F 5 ALA F 7 LEU F 20 ASP F 27 LEU F 28 ILE F 31 SER F 49 PHE F 92 TYR F 98 THR F 111	TOP F1159
3FL9_A_TOPA200	3fl9	TOP DB00440 (Trimethoprim)	Bacillus anthracis	DIHYDROFOLATE REDUCTASE (DHFR)	PF00186 (DHFR_1)	10	MET A 6 ALA A 8 LEU A 21 GLU A 28 VAL A 32 ALA A 50 ILE A 51 LEU A 55 PHE A 96 TYR A 102	TOP A 200
3FL9_B_TOPB200	3fl9	TOP DB00440 (Trimethoprim)	Bacillus anthracis	DIHYDROFOLATE REDUCTASE (DHFR)	no annotation	12	MET B 6 ALA B 8 ASN B 20 LEU B 21 GLU B 28 LEU B 29 VAL B 32 ILE B 51 LEU B 55 PHE B 96 TYR B 102 THR B 115	TOP B 200
3FL9_C_TOPC200	3fl9	TOP DB00440 (Trimethoprim)	Bacillus anthracis	DIHYDROFOLATE REDUCTASE (DHFR)	no annotation	11	MET C 6 ALA C 8 ASN C 20 LEU C 21 GLU C 28 LEU C 29 VAL C 32 ILE C 51 LEU C 55 PHE C 96 THR C 115	TOP C 200
3FL9_D_TOPD200	3fl9	TOP DB00440 (Trimethoprim)	Bacillus anthracis	DIHYDROFOLATE REDUCTASE (DHFR)	no annotation	9	MET D 6 ALA D 8 LEU D 21 GLU D 28 VAL D 32 ILE D 51 LEU D 55 PHE D 96 TYR D 102	TOP D 200
3FL9_E_TOPE200	3fl9	TOP DB00440 (Trimethoprim)	Bacillus anthracis	DIHYDROFOLATE REDUCTASE (DHFR)	no annotation	10	MET E 6 ALA E 8 LEU E 21 GLU E 28 LEU E 29 VAL E 32 ILE E 51 LEU E 55 PHE E 96 THR E 115	TOP E 200
3FL9_F_TOPF200	3fl9	TOP DB00440 (Trimethoprim)	Bacillus anthracis	DIHYDROFOLATE REDUCTASE (DHFR)	no annotation	10	MET F 6 ALA F 8 ASN F 20 LEU F 21 GLU F 28 VAL F 32 ALA F 50 ILE F 51 LEU F 55 PHE F 96	TOP F 200
3FL9_G_TOPG200	3fl9	TOP DB00440 (Trimethoprim)	Bacillus anthracis	DIHYDROFOLATE REDUCTASE (DHFR)	no annotation	12	MET G 6 ALA G 8 ASN G 20 LEU G 21 GLU G 28 LEU G 29 VAL G 32 ILE G 51 LEU G 55 PHE G 96 TYR G 102 THR G 115	TOP G 200
3FL9_H_TOPH200	3fl9	TOP DB00440 (Trimethoprim)	Bacillus anthracis	DIHYDROFOLATE REDUCTASE (DHFR)	no annotation	9	MET H 6 ALA H 8 GLU H 28 LEU H 29 VAL H 32 ILE H 51 LEU H 55 PHE H 96 THR H 115	TOP H 200
3FRB_X_TOPX300	3frb	TOP DB00440 (Trimethoprim)	Staphylococcus aureus	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	11	LEU X 5 ALA X 7 LEU X 20 ASP X 27 LEU X 28 VAL X 31 SER X 49 ILE X 50 PHE X 92 TYR X 98 THR X 111	TOP X 300
3FRE_X_TOPX300	3fre	TOP DB00440 (Trimethoprim)	Staphylococcus aureus	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	9	ALA X 7 LEU X 20 ASP X 27 LEU X 28 VAL X 31 SER X 49 ILE X 50 PHE X 92 THR X 111	TOP X 300
3JW3_A_TOPA208	3jw3	TOP DB00440 (Trimethoprim)	Bacillus anthracis	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	10	MET A 6 ALA A 8 GLU A 28 LEU A 29 VAL A 32 ILE A 51 LEU A 55 ILE A 96 TYR A 102 THR A 115	TOP A 208
3JW3_B_TOPB208	3jw3	TOP DB00440 (Trimethoprim)	Bacillus anthracis	DIHYDROFOLATE REDUCTASE	no annotation	9	MET B 6 ALA B 8 LEU B 21 GLU B 28 VAL B 32 ILE B 51 LEU B 55 ILE B 96 TYR B 102	TOP B 208
3JW5_A_TOPA208	3jw5	TOP DB00440 (Trimethoprim)	Bacillus anthracis	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	11	MET A 6 ALA A 8 ASN A 20 LEU A 21 GLU A 28 LEU A 29 VAL A 32 ASN A 47 ILE A 51 PHE A 96 THR A 115	TOP A 208
3JW5_B_TOPB208	3jw5	TOP DB00440 (Trimethoprim)	Bacillus anthracis	DIHYDROFOLATE REDUCTASE	no annotation	10	MET B 6 ALA B 8 LEU B 21 GLU B 28 LEU B 29 VAL B 32 ILE B 51 LEU B 55 PHE B 96 THR B 115	TOP B 208
3N0H_A_TOPA187	3n0h	TOP DB00440 (Trimethoprim)	Homo sapiens	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	11	ILE A 7 ALA A 9 GLU A 30 PHE A 31 PHE A 34 THR A 56 ILE A 60 LEU A 67 VAL A 115 TYR A 121 THR A 136	TOP A 187
3N0H_A_TOPA191	3n0h	TOP DB00440 (Trimethoprim)	Homo sapiens	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	4	ASP A 21 PRO A 61 LYS A 63 PHE A 64	TOP A 191
3S3V_A_TOPA187	3s3v	TOP DB00440 (Trimethoprim)	Homo sapiens	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	12	ILE A 7 ALA A 9 GLU A 30 PHE A 31 PHE A 34 LYS A 35 THR A 56 ILE A 60 LEU A 67 VAL A 115 TYR A 121 THR A 136	TOP A 187
3S3V_A_TOPA193	3s3v	TOP DB00440 (Trimethoprim)	Homo sapiens	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	5	ASP A 21 LEU A 22 ILE A 60 PRO A 61 PHE A 64	TOP A 193
3TQ8_A_TOPA2001	3tq8	TOP DB00440 (Trimethoprim)	Coxiella burnetii	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	9	ILE A 6 ALA A 8 LEU A 21 ASP A 28 PHE A 32 SER A 50 ILE A 51 ILE A 96 THR A 115	TOP A2001
4G8Z_X_TOPX301	4g8z	TOP DB00440 (Trimethoprim)	Pneumocystis jirovecii	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	10	ILE X 10 ALA X 12 LEU X 25 GLU X 32 PHE X 36 SER X 64 PRO X 66 ILE X 123 TYR X 129 THR X 144	TOP X 301
4KM2_A_TOPA202	4km2	TOP DB00440 (Trimethoprim)	Mycobacterium tuberculosis	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	13	ILE A 5 TRP A 6 ALA A 7 ILE A 20 ASP A 27 PHE A 31 THR A 46 LEU A 50 VAL A 54 LEU A 57 ILE A 94 TYR A 100 THR A 113	TOP A 202
4KM2_B_TOPB202	4km2	TOP DB00440 (Trimethoprim)	Mycobacterium tuberculosis	DIHYDROFOLATE REDUCTASE	no annotation	13	ILE B 5 TRP B 6 ALA B 7 ILE B 20 ASP B 27 PHE B 31 THR B 46 LEU B 50 VAL B 54 LEU B 57 ILE B 94 TYR B 100 THR B 113	TOP B 202
4XT7_A_TOPA302	4xt7	TOP DB00440 (Trimethoprim)	Mycobacterium tuberculosis	RV2671	PF01872 (RibD_C)	11	ASN A 44 ILE A 46 THR A 58 SER A 59 GLY A 60 ASP A 67 ARG A 68 PHE A 71 GLU A 91 GLU A 193 THR A 214	TOP A 302

[["1DG5_A_TOPA201","1dg5","TOP","DB00440(Trimethoprim)","Mycobacterium tuberculosis","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",11,"ILE A   5;TRP A   6;ALA A   7;ILE A  20;ASP A  27;PHE A  31;SER A  49;LEU A  50;PRO A  51;ILE A  94;TYR A 100","TOP A 201\r"],["1DYR_A_TOPA407","1dyr","TOP","DB00440(Trimethoprim)","Pneumocystis carinii","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",11,"ILE A  10;ALA A  12;LEU A  25;GLU A  32;ILE A  33;PHE A  36;ILE A  65;PRO A  66;ILE A 123;TYR A 129;THR A 144","TOP A 407\r"],["2BFM_A_TOPA1290","2bfm","TOP","DB00440(Trimethoprim)","Leishmania major","PTERIDINE REDUCTASE 1","PF00106(adh_short);PF13561(adh_short_C2);no annotation",9,"PHE A 113;ASP A 181;LEU A 188;TYR A 194;LEU A 226;LEU A 229;HIS A 241;TYR A 283;ARG D 287","TOP A1290\r"],["2BFM_B_TOPB1290","2bfm","TOP","DB00440(Trimethoprim)","Leishmania major","PTERIDINE REDUCTASE 1","no annotation",9,"PHE B 113;ASP B 181;LEU B 188;TYR B 191;TYR B 194;LEU B 226;LEU B 229;HIS B 241;ARG C 287","TOP B1290\r"],["2W3A_A_TOPA1190","2w3a","TOP","DB00440(Trimethoprim)","Homo sapiens","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",11,"ILE A   7;ALA A   9;GLU A  30;PHE A  31;PHE A  34;THR A  56;ILE A  60;PRO A  61;VAL A 115;TYR A 121;THR A 136","TOP A1190\r"],["2W3A_B_TOPB1189","2w3a","TOP","DB00440(Trimethoprim)","Homo sapiens","DIHYDROFOLATE REDUCTASE","no annotation",10,"ILE B   7;ALA B   9;GLU B  30;PHE B  31;PHE B  34;THR B  56;ILE B  60;LEU B  67;TYR B 121;THR B 136","TOP B1189\r"],["2W3V_A_TOPA1169","2w3v","TOP","DB00440(Trimethoprim)","Mycobacterium avium","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",12,"VAL A   9;TRP A  10;ALA A  11;ILE A  24;ASP A  31;LEU A  32;PHE A  35;SER A  53;LEU A  54;ILE A 102;TYR A 108;THR A 121","TOP A1169\r"],["2W9G_A_TOPA1159","2w9g","TOP","DB00440(Trimethoprim)","Staphylococcus aureus","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",10,"LEU A   5;ALA A   7;LEU A  20;ASP A  27;LEU A  28;VAL A  31;SER A  49;ILE A  50;PHE A  92;THR A 111","TOP A1159\r"],["2W9H_A_TOPA1160","2w9h","TOP","DB00440(Trimethoprim)","Staphylococcus aureus","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",10,"LEU A   5;ALA A   7;LEU A  20;ASP A  27;LEU A  28;VAL A  31;SER A  49;ILE A  50;PHE A  92;THR A 111","TOP A1160\r"],["2W9S_A_TOPA1160","2w9s","TOP","DB00440(Trimethoprim)","Staphylococcus aureus","DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003","PF00186(DHFR_1)",11,"ILE A   5;ALA A   7;LEU A  20;ASP A  27;LEU A  28;ILE A  31;SER A  49;ILE A  50;PHE A  92;TYR A  98;THR A 111","TOP A1160\r"],["2W9S_B_TOPB1160","2w9s","TOP","DB00440(Trimethoprim)","Staphylococcus aureus","DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003","no annotation",11,"ILE B   5;ALA B   7;LEU B  20;ASP B  27;LEU B  28;ILE B  31;SER B  49;ILE B  50;PHE B  92;TYR B  98;THR B 111","TOP B1160\r"],["2W9S_C_TOPC1160","2w9s","TOP","DB00440(Trimethoprim)","Staphylococcus aureus","DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003","no annotation",10,"ILE C   5;ALA C   7;LEU C  20;ASP C  27;ILE C  31;SER C  49;ILE C  50;PHE C  92;TYR C  98;THR C 111","TOP C1160\r"],["2W9S_D_TOPD1158","2w9s","TOP","DB00440(Trimethoprim)","Staphylococcus aureus","DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003","no annotation",10,"ILE D   5;ALA D   7;LEU D  20;ASP D  27;LEU D  28;ILE D  31;SER D  49;PHE D  92;TYR D  98;THR D 111","TOP D1158\r"],["2W9S_E_TOPE1160","2w9s","TOP","DB00440(Trimethoprim)","Staphylococcus aureus","DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003","no annotation",8,"ILE E   5;ALA E   7;LEU E  20;ASP E  27;ILE E  31;PHE E  92;TYR E  98;THR E 111","TOP E1160\r"],["2W9S_F_TOPF1159","2w9s","TOP","DB00440(Trimethoprim)","Staphylococcus aureus","DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003","no annotation",10,"ILE F   5;ALA F   7;LEU F  20;ASP F  27;LEU F  28;ILE F  31;SER F  49;PHE F  92;TYR F  98;THR F 111","TOP F1159\r"],["3FL9_A_TOPA200","3fl9","TOP","DB00440(Trimethoprim)","Bacillus anthracis","DIHYDROFOLATE REDUCTASE (DHFR)","PF00186(DHFR_1)",10,"MET A   6;ALA A   8;LEU A  21;GLU A  28;VAL A  32;ALA A  50;ILE A  51;LEU A  55;PHE A  96;TYR A 102","TOP A 200\r"],["3FL9_B_TOPB200","3fl9","TOP","DB00440(Trimethoprim)","Bacillus anthracis","DIHYDROFOLATE REDUCTASE (DHFR)","no annotation",12,"MET B   6;ALA B   8;ASN B  20;LEU B  21;GLU B  28;LEU B  29;VAL B  32;ILE B  51;LEU B  55;PHE B  96;TYR B 102;THR B 115","TOP B 200\r"],["3FL9_C_TOPC200","3fl9","TOP","DB00440(Trimethoprim)","Bacillus anthracis","DIHYDROFOLATE REDUCTASE (DHFR)","no annotation",11,"MET C   6;ALA C   8;ASN C  20;LEU C  21;GLU C  28;LEU C  29;VAL C  32;ILE C  51;LEU C  55;PHE C  96;THR C 115","TOP C 200\r"],["3FL9_D_TOPD200","3fl9","TOP","DB00440(Trimethoprim)","Bacillus anthracis","DIHYDROFOLATE REDUCTASE (DHFR)","no annotation",9,"MET D   6;ALA D   8;LEU D  21;GLU D  28;VAL D  32;ILE D  51;LEU D  55;PHE D  96;TYR D 102","TOP D 200\r"],["3FL9_E_TOPE200","3fl9","TOP","DB00440(Trimethoprim)","Bacillus anthracis","DIHYDROFOLATE REDUCTASE (DHFR)","no annotation",10,"MET E   6;ALA E   8;LEU E  21;GLU E  28;LEU E  29;VAL E  32;ILE E  51;LEU E  55;PHE E  96;THR E 115","TOP E 200\r"],["3FL9_F_TOPF200","3fl9","TOP","DB00440(Trimethoprim)","Bacillus anthracis","DIHYDROFOLATE REDUCTASE (DHFR)","no annotation",10,"MET F   6;ALA F   8;ASN F  20;LEU F  21;GLU F  28;VAL F  32;ALA F  50;ILE F  51;LEU F  55;PHE F  96","TOP F 200\r"],["3FL9_G_TOPG200","3fl9","TOP","DB00440(Trimethoprim)","Bacillus anthracis","DIHYDROFOLATE REDUCTASE (DHFR)","no annotation",12,"MET G   6;ALA G   8;ASN G  20;LEU G  21;GLU G  28;LEU G  29;VAL G  32;ILE G  51;LEU G  55;PHE G  96;TYR G 102;THR G 115","TOP G 200\r"],["3FL9_H_TOPH200","3fl9","TOP","DB00440(Trimethoprim)","Bacillus anthracis","DIHYDROFOLATE REDUCTASE (DHFR)","no annotation",9,"MET H   6;ALA H   8;GLU H  28;LEU H  29;VAL H  32;ILE H  51;LEU H  55;PHE H  96;THR H 115","TOP H 200\r"],["3FRB_X_TOPX300","3frb","TOP","DB00440(Trimethoprim)","Staphylococcus aureus","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",11,"LEU X   5;ALA X   7;LEU X  20;ASP X  27;LEU X  28;VAL X  31;SER X  49;ILE X  50;PHE X  92;TYR X  98;THR X 111","TOP X 300\r"],["3FRE_X_TOPX300","3fre","TOP","DB00440(Trimethoprim)","Staphylococcus aureus","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",9,"ALA X   7;LEU X  20;ASP X  27;LEU X  28;VAL X  31;SER X  49;ILE X  50;PHE X  92;THR X 111","TOP X 300\r"],["3JW3_A_TOPA208","3jw3","TOP","DB00440(Trimethoprim)","Bacillus anthracis","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",10,"MET A   6;ALA A   8;GLU A  28;LEU A  29;VAL A  32;ILE A  51;LEU A  55;ILE A  96;TYR A 102;THR A 115","TOP A 208\r"],["3JW3_B_TOPB208","3jw3","TOP","DB00440(Trimethoprim)","Bacillus anthracis","DIHYDROFOLATE REDUCTASE","no annotation",9,"MET B   6;ALA B   8;LEU B  21;GLU B  28;VAL B  32;ILE B  51;LEU B  55;ILE B  96;TYR B 102","TOP B 208\r"],["3JW5_A_TOPA208","3jw5","TOP","DB00440(Trimethoprim)","Bacillus anthracis","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",11,"MET A   6;ALA A   8;ASN A  20;LEU A  21;GLU A  28;LEU A  29;VAL A  32;ASN A  47;ILE A  51;PHE A  96;THR A 115","TOP A 208\r"],["3JW5_B_TOPB208","3jw5","TOP","DB00440(Trimethoprim)","Bacillus anthracis","DIHYDROFOLATE REDUCTASE","no annotation",10,"MET B   6;ALA B   8;LEU B  21;GLU B  28;LEU B  29;VAL B  32;ILE B  51;LEU B  55;PHE B  96;THR B 115","TOP B 208\r"],["3N0H_A_TOPA187","3n0h","TOP","DB00440(Trimethoprim)","Homo sapiens","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",11,"ILE A   7;ALA A   9;GLU A  30;PHE A  31;PHE A  34;THR A  56;ILE A  60;LEU A  67;VAL A 115;TYR A 121;THR A 136","TOP A 187\r"],["3N0H_A_TOPA191","3n0h","TOP","DB00440(Trimethoprim)","Homo sapiens","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",4,"ASP A  21;PRO A  61;LYS A  63;PHE A  64","TOP A 191\r"],["3S3V_A_TOPA187","3s3v","TOP","DB00440(Trimethoprim)","Homo sapiens","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",12,"ILE A   7;ALA A   9;GLU A  30;PHE A  31;PHE A  34;LYS A  35;THR A  56;ILE A  60;LEU A  67;VAL A 115;TYR A 121;THR A 136","TOP A 187\r"],["3S3V_A_TOPA193","3s3v","TOP","DB00440(Trimethoprim)","Homo sapiens","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",5,"ASP A  21;LEU A  22;ILE A  60;PRO A  61;PHE A  64","TOP A 193\r"],["3TQ8_A_TOPA2001","3tq8","TOP","DB00440(Trimethoprim)","Coxiella burnetii","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",9,"ILE A   6;ALA A   8;LEU A  21;ASP A  28;PHE A  32;SER A  50;ILE A  51;ILE A  96;THR A 115","TOP A2001\r"],["4G8Z_X_TOPX301","4g8z","TOP","DB00440(Trimethoprim)","Pneumocystis jirovecii","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",10,"ILE X  10;ALA X  12;LEU X  25;GLU X  32;PHE X  36;SER X  64;PRO X  66;ILE X 123;TYR X 129;THR X 144","TOP X 301\r"],["4KM2_A_TOPA202","4km2","TOP","DB00440(Trimethoprim)","Mycobacterium tuberculosis","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",13,"ILE A   5;TRP A   6;ALA A   7;ILE A  20;ASP A  27;PHE A  31;THR A  46;LEU A  50;VAL A  54;LEU A  57;ILE A  94;TYR A 100;THR A 113","TOP A 202\r"],["4KM2_B_TOPB202","4km2","TOP","DB00440(Trimethoprim)","Mycobacterium tuberculosis","DIHYDROFOLATE REDUCTASE","no annotation",13,"ILE B   5;TRP B   6;ALA B   7;ILE B  20;ASP B  27;PHE B  31;THR B  46;LEU B  50;VAL B  54;LEU B  57;ILE B  94;TYR B 100;THR B 113","TOP B 202\r"],["4XT7_A_TOPA302","4xt7","TOP","DB00440(Trimethoprim)","Mycobacterium tuberculosis","RV2671","PF01872(RibD_C)",11,"ASN A  44;ILE A  46;THR A  58;SER A  59;GLY A  60;ASP A  67;ARG A  68;PHE A  71;GLU A  91;GLU A 193;THR A 214","TOP A 302\r"]]