DRUG BINDING INTERFACES MAPPED TO 'STI'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
1IEP_A_STIA201 | 1iep | STI DB00619(Imatinib) | Mus musculus | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL | PF07714(Pkinase_Tyr) | 18 | LEU A 248TYR A 253VAL A 256ALA A 269LYS A 271GLU A 286VAL A 289MET A 290VAL A 299ILE A 313THR A 315PHE A 317MET A 318GLY A 321ARG A 362LEU A 370ALA A 380ASP A 381 | STI A 201 |
1IEP_B_STIB202 | 1iep | STI DB00619(Imatinib) | Mus musculus | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL | no annotation | 19 | LEU B 248TYR B 253VAL B 256ALA B 269LYS B 271GLU B 286VAL B 289MET B 290ILE B 293VAL B 299ILE B 313THR B 315PHE B 317MET B 318GLY B 321ARG B 362LEU B 370ALA B 380ASP B 381 | STI B 202 |
1OPJ_A_STIA3 | 1opj | STI DB00619(Imatinib) | Mus musculus | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 17 | LEU A 267TYR A 272VAL A 275ALA A 288LYS A 290GLU A 305VAL A 308MET A 309ILE A 312VAL A 318ILE A 332THR A 334PHE A 336MET A 337LEU A 389ALA A 399ASP A 400 | STI A 3 |
1OPJ_B_STIB4 | 1opj | STI DB00619(Imatinib) | Mus musculus | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | no annotation | 18 | LEU B 267TYR B 272VAL B 275ALA B 288LYS B 290GLU B 305VAL B 308MET B 309ILE B 312VAL B 318ILE B 332THR B 334PHE B 336MET B 337GLY B 340ARG B 381ALA B 399ASP B 400 | STI B 4 |
1T46_A_STIA3 | 1t46 | STI DB00619(Imatinib) | Homo sapiens | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG | PF07714(Pkinase_Tyr) | 19 | LEU A 595VAL A 603ALA A 621LYS A 623GLU A 640VAL A 643LEU A 644VAL A 654VAL A 668THR A 670TYR A 672CYS A 673GLY A 676CYS A 788ARG A 791LEU A 799CYS A 809ASP A 810PHE A 811 | STI A 3 |
1XBB_A_STIA1 | 1xbb | STI DB00619(Imatinib) | Homo sapiens | TYROSINE-PROTEINKINASE SYK | PF07714(Pkinase_Tyr) | 9 | LEU A 377VAL A 385ALA A 400MET A 448MET A 450ALA A 451GLY A 454PRO A 455LEU A 501 | STI A 1 |
2HYY_A_STIA600 | 2hyy | STI DB00619(Imatinib) | Homo sapiens | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 18 | LEU A 248TYR A 253VAL A 256ALA A 269LYS A 271GLU A 286VAL A 289MET A 290ILE A 293VAL A 299ILE A 313THR A 315PHE A 317GLY A 321ARG A 362LEU A 370ALA A 380ASP A 381 | STI A 600 |
2HYY_B_STIB600 | 2hyy | STI DB00619(Imatinib) | Homo sapiens | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | no annotation | 18 | LEU B 248TYR B 253VAL B 256ALA B 269LYS B 271GLU B 286VAL B 289MET B 290ILE B 293VAL B 299ILE B 313THR B 315PHE B 317MET B 318GLY B 321LEU B 370ALA B 380ASP B 381 | STI B 600 |
2HYY_C_STIC600 | 2hyy | STI DB00619(Imatinib) | Homo sapiens | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | no annotation | 18 | LEU C 248TYR C 253VAL C 256ALA C 269LYS C 271GLU C 286VAL C 289MET C 290ILE C 293VAL C 299ILE C 313THR C 315PHE C 317MET C 318GLY C 321LEU C 370ALA C 380ASP C 381 | STI C 600 |
2HYY_D_STID600 | 2hyy | STI DB00619(Imatinib) | Homo sapiens | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 | no annotation | 16 | LEU D 248TYR D 253VAL D 256ALA D 269LYS D 271GLU D 286MET D 290ILE D 293VAL D 299ILE D 313THR D 315PHE D 317MET D 318LEU D 370ALA D 380ASP D 381 | STI D 600 |
2OIQ_A_STIA1001 | 2oiq | STI DB00619(Imatinib) | Gallus gallus | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC | PF07714(Pkinase_Tyr) | 17 | LEU A 273VAL A 281ALA A 293LYS A 295GLU A 310VAL A 313MET A 314LEU A 317ILE A 336THR A 338TYR A 340MET A 341GLY A 344ARG A 385LEU A 393ALA A 403ASP A 404 | STI A1001 |
2PL0_A_STIA200 | 2pl0 | STI DB00619(Imatinib) | Homo sapiens | PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK | PF07714(Pkinase_Tyr) | 14 | VAL A 259ALA A 271LYS A 273GLU A 288LEU A 291MET A 292VAL A 301ILE A 314THR A 316TYR A 318MET A 319LEU A 371ALA A 381ASP A 382 | STI A 200 |
3FW1_A_STIA233 | 3fw1 | STI DB00619(Imatinib) | Homo sapiens | RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE[QUINONE] | PF02525(Flavodoxin_2) | 10 | TRP A 105PHE A 106GLY A 149GLY A 150THR A 151MET A 154TYR A 155ASN A 161GLU A 193ILE A 194 | STI A 233 |
3GVU_A_STIA1001 | 3gvu | STI DB00619(Imatinib) | Homo sapiens | TYROSINE-PROTEINKINASE ABL2 | PF07714(Pkinase_Tyr) | 17 | LEU A 294TYR A 299VAL A 302ALA A 315LYS A 317GLU A 332VAL A 335MET A 336ILE A 339VAL A 345ILE A 359THR A 361TYR A 363MET A 364LEU A 416ALA A 426ASP A 427 | STI A1001 |
3GVU_A_STIA1002 | 3gvu | STI DB00619(Imatinib) | Homo sapiens | TYROSINE-PROTEINKINASE ABL2 | PF07714(Pkinase_Tyr) | 8 | ALA A 383VAL A 384LEU A 386LEU A 387ALA A 479GLY A 509PRO A 511VAL A 514 | STI A1002 |
3HEC_A_STIA1 | 3hec | STI DB00619(Imatinib) | Homo sapiens | MITOGEN-ACTIVATEDPROTEIN KINASE 14 | PF00069(Pkinase) | 16 | VAL A 30ALA A 51LYS A 53GLU A 71LEU A 74LEU A 75ILE A 84LEU A 104THR A 106LEU A 108MET A 109ILE A 146ASP A 150LEU A 167ASP A 168PHE A 169 | STI A 1 |
3K5V_A_STIA2 | 3k5v | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 18 | LEU A 267TYR A 272VAL A 275ALA A 288LYS A 290GLU A 305VAL A 308MET A 309ILE A 312VAL A 318ILE A 332THR A 334PHE A 336MET A 337GLY A 340LEU A 389ALA A 399ASP A 400 | STI A 2 |
3K5V_B_STIB2 | 3k5v | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | no annotation | 18 | LEU B 267TYR B 272VAL B 275ALA B 288LYS B 290GLU B 305VAL B 308MET B 309ILE B 312VAL B 318ILE B 332THR B 334PHE B 336MET B 337GLY B 340LEU B 389ALA B 399ASP B 400 | STI B 2 |
3MS9_A_STIA1 | 3ms9 | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 18 | LEU A 248TYR A 253VAL A 256ALA A 269LYS A 271GLU A 286VAL A 289MET A 290ILE A 293VAL A 299ILE A 313THR A 315PHE A 317MET A 318ARG A 362LEU A 370ALA A 380ASP A 381 | STI A 1 |
3MS9_B_STIB1 | 3ms9 | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | no annotation | 19 | LEU B 248TYR B 253VAL B 256ALA B 269LYS B 271GLU B 286VAL B 289MET B 290ILE B 293VAL B 299ILE B 313THR B 315PHE B 317MET B 318GLY B 321ARG B 362LEU B 370ALA B 380ASP B 381 | STI B 1 |
3MSS_A_STIA1 | 3mss | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 18 | LEU A 248TYR A 253VAL A 256ALA A 269LYS A 271GLU A 286VAL A 289MET A 290ILE A 293VAL A 299ILE A 313THR A 315PHE A 317MET A 318ARG A 362LEU A 370ALA A 380ASP A 381 | STI A 1 |
3MSS_B_STIB1 | 3mss | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | no annotation | 19 | LEU B 248TYR B 253VAL B 256ALA B 269LYS B 271GLU B 286VAL B 289MET B 290ILE B 293VAL B 299ILE B 313THR B 315PHE B 317MET B 318GLY B 321ARG B 362LEU B 370ALA B 380ASP B 381 | STI B 1 |
3MSS_C_STIC1 | 3mss | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | no annotation | 18 | LEU C 248TYR C 253VAL C 256ALA C 269LYS C 271GLU C 286VAL C 289MET C 290ILE C 293VAL C 299ILE C 313THR C 315PHE C 317MET C 318ARG C 362LEU C 370ALA C 380ASP C 381 | STI C 1 |
3MSS_D_STID1 | 3mss | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | no annotation | 18 | LEU D 248TYR D 253VAL D 256ALA D 269LYS D 271GLU D 286VAL D 289MET D 290ILE D 293VAL D 299ILE D 313THR D 315PHE D 317MET D 318GLY D 321LEU D 370ALA D 380ASP D 381 | STI D 1 |
3OEZ_A_STIA601 | 3oez | STI DB00619(Imatinib) | Gallus gallus | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC | PF07714(Pkinase_Tyr) | 17 | VAL A 281ALA A 293LYS A 295GLU A 310VAL A 313MET A 314ILE A 317VAL A 323ILE A 336THR A 338TYR A 340MET A 341GLY A 344ARG A 385LEU A 393ALA A 403ASP A 404 | STI A 601 |
3OEZ_B_STIB601 | 3oez | STI DB00619(Imatinib) | Gallus gallus | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC | no annotation | 14 | VAL B 281ALA B 293LYS B 295GLU B 310VAL B 313MET B 314ILE B 336THR B 338TYR B 340MET B 341ARG B 385LEU B 393ALA B 403ASP B 404 | STI B 601 |
3PYY_A_STIA3 | 3pyy | STI DB00619(Imatinib) | Homo sapiens | V-ABL ABELSON MURINELEUKEMIA VIRALONCOGENE HOMOLOG 1ISOFORM B VARIANT | PF07714(Pkinase_Tyr) | 18 | LEU A 267TYR A 272VAL A 275ALA A 288LYS A 290GLU A 305VAL A 308MET A 309ILE A 312VAL A 318ILE A 332THR A 334PHE A 336GLY A 340ARG A 381LEU A 389ALA A 399ASP A 400 | STI A 3 |
3PYY_B_STIB4 | 3pyy | STI DB00619(Imatinib) | Homo sapiens | V-ABL ABELSON MURINELEUKEMIA VIRALONCOGENE HOMOLOG 1ISOFORM B VARIANT | no annotation | 17 | LEU B 267TYR B 272VAL B 275ALA B 288LYS B 290GLU B 305VAL B 308MET B 309ILE B 312VAL B 318ILE B 332THR B 334MET B 337ARG B 381LEU B 389ALA B 399ASP B 400 | STI B 4 |
4BKJ_A_STIA1000 | 4bkj | STI DB00619(Imatinib) | Homo sapiens | EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1 | PF07714(Pkinase_Tyr) | 16 | VAL A 624ALA A 653LYS A 655GLU A 672ILE A 675MET A 676LEU A 679ILE A 685MET A 699THR A 701TYR A 703MET A 704ARG A 765LEU A 773ALA A 783ASP A 784 | STI A1000 |
4BKJ_B_STIB1000 | 4bkj | STI DB00619(Imatinib) | Homo sapiens | EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1 | no annotation | 17 | VAL B 624ALA B 653LYS B 655GLU B 672ILE B 675MET B 676LEU B 679ILE B 685MET B 699THR B 701TYR B 703MET B 704ARG B 765LEU B 773ALA B 783ASP B 784PHE B 785 | STI B1000 |
4CSV_A_STIA1265 | 4csv | STI DB00619(Imatinib) | syntheticconstruct | SRC-ABL TYROSINEKINASE ANCESTOR | PF07714(Pkinase_Tyr) | 16 | VAL A 22ALA A 35LYS A 37GLU A 52ILE A 55MET A 56VAL A 65ILE A 79THR A 81TYR A 83MET A 84PHE A 125LEU A 136ALA A 146ASP A 147PHE A 148 | STI A1265 |
4R7I_A_STIA1001 | 4r7i | STI DB00619(Imatinib) | Homo sapiens | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTOR | PF07714(Pkinase_Tyr) | 17 | LEU A 588VAL A 596ALA A 614LYS A 616GLU A 633MET A 637VAL A 647VAL A 661THR A 663TYR A 665CYS A 666CYS A 774ARG A 777LEU A 785GLY A 795ASP A 796PHE A 797 | STI A1001 |
5MQT_A_STIA302 | 5mqt | STI DB00619(Imatinib) | Homo sapiens | DEOXYCYTIDINE KINASE | no annotation | 12 | ILE A 30VAL A 55MET A 85TYR A 86PRO A 89GLU A 90GLN A 97ARG A 128PHE A 137SER A 144CYS A 146GLU A 197 | STI A 302 |
5MQT_C_STIC302 | 5mqt | STI DB00619(Imatinib) | Homo sapiens | DEOXYCYTIDINE KINASE | no annotation | 13 | ILE C 30GLU C 53VAL C 55LEU C 82MET C 85PRO C 89GLU C 90GLN C 97ARG C 128LEU C 141GLU C 196GLU C 197TYR C 204 | STI C 302 |
6HD4_A_STIA604 | 6hd4 | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 17 | TYR A 272VAL A 275ALA A 288LYS A 290GLU A 305VAL A 308MET A 309ILE A 312VAL A 318ILE A 332THR A 334PHE A 336MET A 337GLY A 340LEU A 389ALA A 399ASP A 400 | STI A 604 |
6HD4_B_STIB602 | 6hd4 | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | None | 18 | LEU B 267TYR B 272VAL B 275ALA B 288LYS B 290GLU B 305VAL B 308MET B 309ILE B 312VAL B 318ILE B 332THR B 334PHE B 336MET B 337GLY B 340LEU B 389ALA B 399ASP B 400 | STI B 602 |
6HD6_A_STIA603 | 6hd6 | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | PF07714(Pkinase_Tyr) | 17 | LEU A 267TYR A 272VAL A 275ALA A 288LYS A 290GLU A 305MET A 309ILE A 312VAL A 318ILE A 332THR A 334PHE A 336MET A 337GLY A 340LEU A 389ALA A 399ASP A 400 | STI A 603 |
6HD6_B_STIB601 | 6hd6 | STI DB00619(Imatinib) | Mus musculus | TYROSINE-PROTEINKINASE ABL1 | None | 19 | LEU B 267TYR B 272VAL B 275ALA B 288LYS B 290GLU B 305VAL B 308MET B 309ILE B 312VAL B 318ILE B 332THR B 334PHE B 336MET B 337GLY B 340ARG B 381LEU B 389ALA B 399ASP B 400 | STI B 601 |