DRUG BINDING INTERFACES MAPPED TO 'SHH'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)

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DrReposER ID	PDB	Ligand	Organism	Macromolecule	Pfam	Res.	Interface	HETATM
1C3S_A_SHHA952	1c3s	SHH DB02546 (Vorinostat)	Aquifex aeolicus	HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)	PF00850 (Hist_deacetyl)	11	PRO A 22 TYR A 91 HIS A 131 HIS A 132 PHE A 141 ASP A 168 HIS A 170 PHE A 198 ASP A 258 LEU A 265 TYR A 297	SHH A 952
1T69_A_SHHA379	1t69	SHH DB02546 (Vorinostat)	Homo sapiens	HISTONE DEACETYLASE 8	PF00850 (Hist_deacetyl)	12	TYR A 100 ASP A 101 HIS A 142 HIS A 143 GLY A 151 PHE A 152 ASP A 178 HIS A 180 PHE A 208 ASP A 267 MET A 274 TYR A 306	SHH A 379
1ZZ1_A_SHHA2452	1zz1	SHH DB02546 (Vorinostat)	Alcaligenaceae bacterium FB188	HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE	PF00850 (Hist_deacetyl)	11	LEU A 21 ILE A 100 HIS A 142 HIS A 143 PHE A 152 ASP A 180 HIS A 182 PHE A 208 ASP A 268 GLY A 310 TYR A 312	SHH A2452
1ZZ1_B_SHHB2552	1zz1	SHH DB02546 (Vorinostat)	Alcaligenaceae bacterium FB188	HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE	no annotation	12	LEU B 21 ILE B 100 HIS B 142 HIS B 143 PHE B 152 ASP B 180 HIS B 182 PHE B 208 ASP B 268 GLY B 310 TYR B 312 PHE C 341	SHH B2552
1ZZ1_C_SHHC2652	1zz1	SHH DB02546 (Vorinostat)	Alcaligenaceae bacterium FB188	HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE	no annotation	12	LEU C 21 ASP C 98 ILE C 100 HIS C 142 HIS C 143 GLY C 151 ASP C 180 HIS C 182 PHE C 208 ASP C 268 GLY C 310 TYR C 312	SHH C2652
1ZZ1_D_SHHD2752	1zz1	SHH DB02546 (Vorinostat)	Alcaligenaceae bacterium FB188	HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE	no annotation	9	ILE D 100 HIS D 142 HIS D 143 PHE D 152 ASP D 180 HIS D 182 PHE D 208 ASP D 268 TYR D 312	SHH D2752
3C0Z_A_SHHA301	3c0z	SHH DB02546 (Vorinostat)	Homo sapiens	HISTONE DEACETYLASE 7A	PF00850 (Hist_deacetyl)	5	HIS A 669 HIS A 670 ASP A 707 HIS A 709 ASP A 801	SHH A 301
3C0Z_B_SHHB301	3c0z	SHH DB02546 (Vorinostat)	Homo sapiens	HISTONE DEACETYLASE 7A	no annotation	8	HIS B 669 HIS B 670 PHE B 679 ASP B 707 HIS B 709 PHE B 738 ASP B 801 GLY B 841	SHH B 301
3C0Z_C_SHHC301	3c0z	SHH DB02546 (Vorinostat)	Homo sapiens	HISTONE DEACETYLASE 7A	no annotation	6	ASP C 626 HIS C 669 HIS C 670 ASP C 707 HIS C 709 ASP C 801	SHH C 301
4BZ6_A_SHHA700	4bz6	SHH DB02546 (Vorinostat)	Schistosoma mansoni	HISTONE DEACETYLASE 8	PF00850 (Hist_deacetyl)	10	LYS A 20 HIS A 141 HIS A 142 ASP A 186 HIS A 188 ASP A 285 PRO A 291 HIS A 292 GLY A 339 TYR A 341	SHH A 700
4BZ6_B_SHHB700	4bz6	SHH DB02546 (Vorinostat)	Schistosoma mansoni	HISTONE DEACETYLASE 8	PF00850 (Hist_deacetyl) no annotation	12	LYS B 20 ASP A 50 HIS B 141 HIS B 142 ASP B 186 HIS B 188 PHE B 216 ASP B 285 PRO B 291 HIS B 292 GLY B 339 TYR B 341	SHH B 700
4BZ6_C_SHHC700	4bz6	SHH DB02546 (Vorinostat)	Schistosoma mansoni	HISTONE DEACETYLASE 8	no annotation	13	LYS C 20 ASP D 50 HIS C 141 HIS C 142 GLY C 150 ASP C 186 HIS C 188 PHE C 216 ASP C 285 PRO C 291 HIS C 292 GLY C 339 TYR C 341	SHH C 700
4BZ6_D_SHHD700	4bz6	SHH DB02546 (Vorinostat)	Schistosoma mansoni	HISTONE DEACETYLASE 8	no annotation	10	LYS D 20 HIS D 141 HIS D 142 ASP D 186 HIS D 188 ASP D 285 PRO D 291 HIS D 292 GLY D 339 TYR D 341	SHH D 700
4LXZ_A_SHHA407	4lxz	SHH DB02546 (Vorinostat)	Homo sapiens	HISTONE DEACETYLASE 2	PF00850 (Hist_deacetyl)	12	HIS A 33 PRO A 34 ASP A 104 HIS A 145 HIS A 146 GLY A 154 PHE A 155 ASP A 181 HIS A 183 ASP A 269 GLY A 306 TYR A 308	SHH A 407
4LXZ_B_SHHB408	4lxz	SHH DB02546 (Vorinostat)	Homo sapiens	HISTONE DEACETYLASE 2	no annotation	11	HIS B 33 PRO B 34 ASP B 104 HIS B 145 HIS B 146 PHE B 155 ASP B 181 HIS B 183 ASP B 269 GLY B 306 TYR B 308	SHH B 408
4LXZ_C_SHHC406	4lxz	SHH DB02546 (Vorinostat)	Homo sapiens	HISTONE DEACETYLASE 2	no annotation	12	PRO C 34 ASP C 104 HIS C 145 HIS C 146 GLY C 154 PHE C 155 ASP C 181 HIS C 183 PHE C 210 ASP C 269 GLY C 306 TYR C 308	SHH C 406
4QA0_A_SHHA404	4qa0	SHH DB02546 (Vorinostat)	Homo sapiens	HISTONE DEACETYLASE 8	PF00850 (Hist_deacetyl) no annotation	15	TYR A 100 HIS A 142 HIS A 143 GLY A 151 PHE A 152 ASP A 178 HIS A 180 PHE A 208 ASP A 267 PRO B 273 MET A 274 MET B 274 GLY A 304 TYR A 306 TYR B 306	SHH A 404
4QA0_B_SHHB404	4qa0	SHH DB02546 (Vorinostat)	Homo sapiens	HISTONE DEACETYLASE 8	PF00850 (Hist_deacetyl) no annotation	14	TYR B 100 HIS B 142 HIS B 143 PHE B 152 ASP B 178 HIS B 180 PHE B 208 ASP B 267 PRO A 273 MET A 274 MET B 274 GLY B 304 TYR A 306 TYR B 306	SHH B 404
4QA2_A_SHHA404	4qa2	SHH DB02546 (Vorinostat)	Homo sapiens	HISTONE DEACETYLASE 8	PF00850 (Hist_deacetyl) no annotation	15	TYR A 100 HIS A 142 HIS A 143 GLY A 151 PHE A 152 ASP A 178 HIS A 180 PHE A 208 ASP A 267 PRO B 273 MET A 274 MET B 274 GLY A 304 TYR A 306 TYR B 306	SHH A 404
4QA2_B_SHHB404	4qa2	SHH DB02546 (Vorinostat)	Homo sapiens	HISTONE DEACETYLASE 8	PF00850 (Hist_deacetyl) no annotation	14	TYR B 100 HIS B 142 HIS B 143 GLY B 151 PHE B 152 ASP B 178 HIS B 180 PHE B 208 ASP B 267 PRO A 273 MET B 274 GLY B 304 TYR A 306 TYR B 306	SHH B 404
4R7L_A_SHHA709	4r7l	SHH DB02546 (Vorinostat)	Homo sapiens	LEUKOTRIENE A-4 HYDROLASE	PF01433 (Peptidase_M1) PF09127 (Leuk-A4-hydro_C)	14	GLN A 136 ALA A 137 TYR A 267 GLU A 271 HIS A 295 GLU A 296 HIS A 299 TRP A 311 PHE A 314 GLU A 318 LEU A 369 PRO A 374 TYR A 378 TYR A 383	SHH A 709
5EEI_A_SHHA2004	5eei	SHH DB02546 (Vorinostat)	Danio rerio	HDAC6 PROTEIN	PF00850 (Hist_deacetyl)	14	HIS A 463 PRO A 464 SER A 531 HIS A 573 HIS A 574 GLY A 582 PHE A 583 ASP A 612 HIS A 614 PHE A 643 ASP A 705 LEU A 712 GLY A 743 TYR A 745	SHH A2004
5EEI_B_SHHB801	5eei	SHH DB02546 (Vorinostat)	Danio rerio	HDAC6 PROTEIN	no annotation	14	HIS B 463 PRO B 464 SER B 531 HIS B 573 HIS B 574 GLY B 582 PHE B 583 ASP B 612 HIS B 614 PHE B 643 ASP B 705 LEU B 712 GLY B 743 TYR B 745	SHH B 801

[["1C3S_A_SHHA952","1c3s","SHH","DB02546(Vorinostat)","Aquifex aeolicus","HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)","PF00850(Hist_deacetyl)",11,"PRO A  22;TYR A  91;HIS A 131;HIS A 132;PHE A 141;ASP A 168;HIS A 170;PHE A 198;ASP A 258;LEU A 265;TYR A 297","SHH A 952\r"],["1T69_A_SHHA379","1t69","SHH","DB02546(Vorinostat)","Homo sapiens","HISTONE DEACETYLASE 8","PF00850(Hist_deacetyl)",12,"TYR A 100;ASP A 101;HIS A 142;HIS A 143;GLY A 151;PHE A 152;ASP A 178;HIS A 180;PHE A 208;ASP A 267;MET A 274;TYR A 306","SHH A 379\r"],["1ZZ1_A_SHHA2452","1zz1","SHH","DB02546(Vorinostat)","Alcaligenaceae bacterium FB188","HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE","PF00850(Hist_deacetyl)",11,"LEU A  21;ILE A 100;HIS A 142;HIS A 143;PHE A 152;ASP A 180;HIS A 182;PHE A 208;ASP A 268;GLY A 310;TYR A 312","SHH A2452\r"],["1ZZ1_B_SHHB2552","1zz1","SHH","DB02546(Vorinostat)","Alcaligenaceae bacterium FB188","HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE","no annotation",12,"LEU B  21;ILE B 100;HIS B 142;HIS B 143;PHE B 152;ASP B 180;HIS B 182;PHE B 208;ASP B 268;GLY B 310;TYR B 312;PHE C 341","SHH B2552\r"],["1ZZ1_C_SHHC2652","1zz1","SHH","DB02546(Vorinostat)","Alcaligenaceae bacterium FB188","HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE","no annotation",12,"LEU C  21;ASP C  98;ILE C 100;HIS C 142;HIS C 143;GLY C 151;ASP C 180;HIS C 182;PHE C 208;ASP C 268;GLY C 310;TYR C 312","SHH C2652\r"],["1ZZ1_D_SHHD2752","1zz1","SHH","DB02546(Vorinostat)","Alcaligenaceae bacterium FB188","HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE","no annotation",9,"ILE D 100;HIS D 142;HIS D 143;PHE D 152;ASP D 180;HIS D 182;PHE D 208;ASP D 268;TYR D 312","SHH D2752\r"],["3C0Z_A_SHHA301","3c0z","SHH","DB02546(Vorinostat)","Homo sapiens","HISTONE DEACETYLASE 7A","PF00850(Hist_deacetyl)",5,"HIS A 669;HIS A 670;ASP A 707;HIS A 709;ASP A 801","SHH A 301\r"],["3C0Z_B_SHHB301","3c0z","SHH","DB02546(Vorinostat)","Homo sapiens","HISTONE DEACETYLASE 7A","no annotation",8,"HIS B 669;HIS B 670;PHE B 679;ASP B 707;HIS B 709;PHE B 738;ASP B 801;GLY B 841","SHH B 301\r"],["3C0Z_C_SHHC301","3c0z","SHH","DB02546(Vorinostat)","Homo sapiens","HISTONE DEACETYLASE 7A","no annotation",6,"ASP C 626;HIS C 669;HIS C 670;ASP C 707;HIS C 709;ASP C 801","SHH C 301\r"],["4BZ6_A_SHHA700","4bz6","SHH","DB02546(Vorinostat)","Schistosoma mansoni","HISTONE DEACETYLASE 8","PF00850(Hist_deacetyl)",10,"LYS A  20;HIS A 141;HIS A 142;ASP A 186;HIS A 188;ASP A 285;PRO A 291;HIS A 292;GLY A 339;TYR A 341","SHH A 700\r"],["4BZ6_B_SHHB700","4bz6","SHH","DB02546(Vorinostat)","Schistosoma mansoni","HISTONE DEACETYLASE 8","PF00850(Hist_deacetyl);no annotation",12,"LYS B  20;ASP A  50;HIS B 141;HIS B 142;ASP B 186;HIS B 188;PHE B 216;ASP B 285;PRO B 291;HIS B 292;GLY B 339;TYR B 341","SHH B 700\r"],["4BZ6_C_SHHC700","4bz6","SHH","DB02546(Vorinostat)","Schistosoma mansoni","HISTONE DEACETYLASE 8","no annotation",13,"LYS C  20;ASP D  50;HIS C 141;HIS C 142;GLY C 150;ASP C 186;HIS C 188;PHE C 216;ASP C 285;PRO C 291;HIS C 292;GLY C 339;TYR C 341","SHH C 700\r"],["4BZ6_D_SHHD700","4bz6","SHH","DB02546(Vorinostat)","Schistosoma mansoni","HISTONE DEACETYLASE 8","no annotation",10,"LYS D  20;HIS D 141;HIS D 142;ASP D 186;HIS D 188;ASP D 285;PRO D 291;HIS D 292;GLY D 339;TYR D 341","SHH D 700\r"],["4LXZ_A_SHHA407","4lxz","SHH","DB02546(Vorinostat)","Homo sapiens","HISTONE DEACETYLASE 2","PF00850(Hist_deacetyl)",12,"HIS A  33;PRO A  34;ASP A 104;HIS A 145;HIS A 146;GLY A 154;PHE A 155;ASP A 181;HIS A 183;ASP A 269;GLY A 306;TYR A 308","SHH A 407\r"],["4LXZ_B_SHHB408","4lxz","SHH","DB02546(Vorinostat)","Homo sapiens","HISTONE DEACETYLASE 2","no annotation",11,"HIS B  33;PRO B  34;ASP B 104;HIS B 145;HIS B 146;PHE B 155;ASP B 181;HIS B 183;ASP B 269;GLY B 306;TYR B 308","SHH B 408\r"],["4LXZ_C_SHHC406","4lxz","SHH","DB02546(Vorinostat)","Homo sapiens","HISTONE DEACETYLASE 2","no annotation",12,"PRO C  34;ASP C 104;HIS C 145;HIS C 146;GLY C 154;PHE C 155;ASP C 181;HIS C 183;PHE C 210;ASP C 269;GLY C 306;TYR C 308","SHH C 406\r"],["4QA0_A_SHHA404","4qa0","SHH","DB02546(Vorinostat)","Homo sapiens","HISTONE DEACETYLASE 8","PF00850(Hist_deacetyl);no annotation",15,"TYR A 100;HIS A 142;HIS A 143;GLY A 151;PHE A 152;ASP A 178;HIS A 180;PHE A 208;ASP A 267;PRO B 273;MET A 274;MET B 274;GLY A 304;TYR A 306;TYR B 306","SHH A 404\r"],["4QA0_B_SHHB404","4qa0","SHH","DB02546(Vorinostat)","Homo sapiens","HISTONE DEACETYLASE 8","PF00850(Hist_deacetyl);no annotation",14,"TYR B 100;HIS B 142;HIS B 143;PHE B 152;ASP B 178;HIS B 180;PHE B 208;ASP B 267;PRO A 273;MET A 274;MET B 274;GLY B 304;TYR A 306;TYR B 306","SHH B 404\r"],["4QA2_A_SHHA404","4qa2","SHH","DB02546(Vorinostat)","Homo sapiens","HISTONE DEACETYLASE 8","PF00850(Hist_deacetyl);no annotation",15,"TYR A 100;HIS A 142;HIS A 143;GLY A 151;PHE A 152;ASP A 178;HIS A 180;PHE A 208;ASP A 267;PRO B 273;MET A 274;MET B 274;GLY A 304;TYR A 306;TYR B 306","SHH A 404\r"],["4QA2_B_SHHB404","4qa2","SHH","DB02546(Vorinostat)","Homo sapiens","HISTONE DEACETYLASE 8","PF00850(Hist_deacetyl);no annotation",14,"TYR B 100;HIS B 142;HIS B 143;GLY B 151;PHE B 152;ASP B 178;HIS B 180;PHE B 208;ASP B 267;PRO A 273;MET B 274;GLY B 304;TYR A 306;TYR B 306","SHH B 404\r"],["4R7L_A_SHHA709","4r7l","SHH","DB02546(Vorinostat)","Homo sapiens","LEUKOTRIENE A-4 HYDROLASE","PF01433(Peptidase_M1);PF09127(Leuk-A4-hydro_C)",14,"GLN A 136;ALA A 137;TYR A 267;GLU A 271;HIS A 295;GLU A 296;HIS A 299;TRP A 311;PHE A 314;GLU A 318;LEU A 369;PRO A 374;TYR A 378;TYR A 383","SHH A 709\r"],["5EEI_A_SHHA2004","5eei","SHH","DB02546(Vorinostat)","Danio rerio","HDAC6 PROTEIN","PF00850(Hist_deacetyl)",14,"HIS A 463;PRO A 464;SER A 531;HIS A 573;HIS A 574;GLY A 582;PHE A 583;ASP A 612;HIS A 614;PHE A 643;ASP A 705;LEU A 712;GLY A 743;TYR A 745","SHH A2004\r"],["5EEI_B_SHHB801","5eei","SHH","DB02546(Vorinostat)","Danio rerio","HDAC6 PROTEIN","no annotation",14,"HIS B 463;PRO B 464;SER B 531;HIS B 573;HIS B 574;GLY B 582;PHE B 583;ASP B 612;HIS B 614;PHE B 643;ASP B 705;LEU B 712;GLY B 743;TYR B 745","SHH B 801\r"]]