DRUG BINDING INTERFACES MAPPED TO 'ROF'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)

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DrReposER ID	PDB	Ligand	Organism	Macromolecule	Pfam	Res.	Interface	HETATM
1XMU_A_ROFA101	1xmu	ROF DB01656 (Roflumilast)	Homo sapiens	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B	PF00233 (PDEase_I)	17	TYR A 233 HIS A 234 MET A 347 ASP A 392 LEU A 393 ASN A 395 PRO A 396 TYR A 403 TRP A 406 THR A 407 ILE A 410 MET A 411 PHE A 414 MET A 431 SER A 442 GLN A 443 PHE A 446	ROF A 101
1XMU_B_ROFB102	1xmu	ROF DB01656 (Roflumilast)	Homo sapiens	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B	PF00233 (PDEase_I)	17	TYR B 233 HIS B 234 MET B 347 ASP B 392 LEU B 393 ASN B 395 PRO B 396 TYR B 403 TRP B 406 THR B 407 ILE B 410 MET B 411 PHE B 414 MET B 431 SER B 442 GLN B 443 PHE B 446	ROF B 102
1XOQ_A_ROFA502	1xoq	ROF DB01656 (Roflumilast)	Homo sapiens	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D	PF00233 (PDEase_I)	15	TYR A 159 HIS A 160 MET A 273 ASP A 318 LEU A 319 ASN A 321 PRO A 322 TYR A 329 TRP A 332 THR A 333 ILE A 336 MET A 357 SER A 368 GLN A 369 PHE A 372	ROF A 502
1XOQ_B_ROFB501	1xoq	ROF DB01656 (Roflumilast)	Homo sapiens	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D	None	15	TYR B 159 HIS B 160 MET B 273 ASP B 318 LEU B 319 ASN B 321 PRO B 322 TYR B 329 TRP B 332 THR B 333 ILE B 336 MET B 357 SER B 368 GLN B 369 PHE B 372	ROF B 501
3G4L_A_ROFA901	3g4l	ROF DB01656 (Roflumilast)	Homo sapiens	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D	PF00233 (PDEase_I)	15	TYR A 325 HIS A 326 MET A 439 ASP A 484 LEU A 485 ASN A 487 PRO A 488 TYR A 495 TRP A 498 THR A 499 ILE A 502 MET A 523 SER A 534 GLN A 535 PHE A 538	ROF A 901
3G4L_B_ROFB902	3g4l	ROF DB01656 (Roflumilast)	Homo sapiens	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D	None	14	TYR B 325 HIS B 326 MET B 439 ASP B 484 LEU B 485 ASN B 487 PRO B 488 TRP B 498 THR B 499 ILE B 502 MET B 503 MET B 523 GLN B 535 PHE B 538	ROF B 902
3G4L_C_ROFC903	3g4l	ROF DB01656 (Roflumilast)	Homo sapiens	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D	None	15	TYR C 325 HIS C 326 MET C 439 ASP C 484 LEU C 485 ASN C 487 PRO C 488 TYR C 495 TRP C 498 THR C 499 ILE C 502 MET C 523 SER C 534 GLN C 535 PHE C 538	ROF C 903
3G4L_D_ROFD904	3g4l	ROF DB01656 (Roflumilast)	Homo sapiens	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D	None	15	TYR D 325 HIS D 326 MET D 439 ASP D 484 LEU D 485 ASN D 487 PRO D 488 TRP D 498 THR D 499 ILE D 502 MET D 503 MET D 523 SER D 534 GLN D 535 PHE D 538	ROF D 904

[["1XMU_A_ROFA101","1xmu","ROF","DB01656(Roflumilast)","Homo sapiens","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B","PF00233(PDEase_I)",17,"TYR A 233;HIS A 234;MET A 347;ASP A 392;LEU A 393;ASN A 395;PRO A 396;TYR A 403;TRP A 406;THR A 407;ILE A 410;MET A 411;PHE A 414;MET A 431;SER A 442;GLN A 443;PHE A 446","ROF A 101\r"],["1XMU_B_ROFB102","1xmu","ROF","DB01656(Roflumilast)","Homo sapiens","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B","PF00233(PDEase_I)",17,"TYR B 233;HIS B 234;MET B 347;ASP B 392;LEU B 393;ASN B 395;PRO B 396;TYR B 403;TRP B 406;THR B 407;ILE B 410;MET B 411;PHE B 414;MET B 431;SER B 442;GLN B 443;PHE B 446","ROF B 102\r"],["1XOQ_A_ROFA502","1xoq","ROF","DB01656(Roflumilast)","Homo sapiens","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","PF00233(PDEase_I)",15,"TYR A 159;HIS A 160;MET A 273;ASP A 318;LEU A 319;ASN A 321;PRO A 322;TYR A 329;TRP A 332;THR A 333;ILE A 336;MET A 357;SER A 368;GLN A 369;PHE A 372","ROF A 502\r"],["1XOQ_B_ROFB501","1xoq","ROF","DB01656(Roflumilast)","Homo sapiens","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","None",15,"TYR B 159;HIS B 160;MET B 273;ASP B 318;LEU B 319;ASN B 321;PRO B 322;TYR B 329;TRP B 332;THR B 333;ILE B 336;MET B 357;SER B 368;GLN B 369;PHE B 372","ROF B 501\r"],["3G4L_A_ROFA901","3g4l","ROF","DB01656(Roflumilast)","Homo sapiens","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","PF00233(PDEase_I)",15,"TYR A 325;HIS A 326;MET A 439;ASP A 484;LEU A 485;ASN A 487;PRO A 488;TYR A 495;TRP A 498;THR A 499;ILE A 502;MET A 523;SER A 534;GLN A 535;PHE A 538","ROF A 901\r"],["3G4L_B_ROFB902","3g4l","ROF","DB01656(Roflumilast)","Homo sapiens","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","None",14,"TYR B 325;HIS B 326;MET B 439;ASP B 484;LEU B 485;ASN B 487;PRO B 488;TRP B 498;THR B 499;ILE B 502;MET B 503;MET B 523;GLN B 535;PHE B 538","ROF B 902\r"],["3G4L_C_ROFC903","3g4l","ROF","DB01656(Roflumilast)","Homo sapiens","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","None",15,"TYR C 325;HIS C 326;MET C 439;ASP C 484;LEU C 485;ASN C 487;PRO C 488;TYR C 495;TRP C 498;THR C 499;ILE C 502;MET C 523;SER C 534;GLN C 535;PHE C 538","ROF C 903\r"],["3G4L_D_ROFD904","3g4l","ROF","DB01656(Roflumilast)","Homo sapiens","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","None",15,"TYR D 325;HIS D 326;MET D 439;ASP D 484;LEU D 485;ASN D 487;PRO D 488;TRP D 498;THR D 499;ILE D 502;MET D 503;MET D 523;SER D 534;GLN D 535;PHE D 538","ROF D 904\r"]]