DRUG BINDING INTERFACES MAPPED TO 'IRE'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)

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DrReposER ID	PDB	Ligand	Organism	Macromolecule	Pfam	Res.	Interface	HETATM
2ITO_A_IREA2020	2ito	IRE DB00317 (Gefitinib)	Homo sapiens	EPIDERMAL GROWTH FACTOR RECEPTOR	PF07714 (Pkinase_Tyr)	13	LEU A 718 SER A 719 ALA A 743 LYS A 745 GLU A 762 MET A 766 LEU A 788 THR A 790 MET A 793 GLY A 796 ASP A 800 LEU A 844 THR A 854	IRE A2020
2ITY_A_IREA2020	2ity	IRE DB00317 (Gefitinib)	Homo sapiens	EPIDERMAL GROWTH FACTOR RECEPTOR	PF07714 (Pkinase_Tyr)	13	LEU A 718 GLY A 719 VAL A 726 ALA A 743 LYS A 745 GLU A 762 MET A 766 LEU A 788 THR A 790 MET A 793 GLY A 796 LEU A 844 ASP A 855	IRE A2020
2ITZ_A_IREA2021	2itz	IRE DB00317 (Gefitinib)	Homo sapiens	EPIDERMAL GROWTH FACTOR RECEPTOR	PF07714 (Pkinase_Tyr)	15	LEU A 718 VAL A 726 ALA A 743 LYS A 745 GLU A 762 MET A 766 LEU A 788 THR A 790 LEU A 792 MET A 793 GLY A 796 ASP A 800 LEU A 844 THR A 854 ASP A 855	IRE A2021
3UG2_A_IREA1	3ug2	IRE DB00317 (Gefitinib)	Homo sapiens	EPIDERMAL GROWTH FACTOR RECEPTOR	PF07714 (Pkinase_Tyr)	12	LEU A 718 SER A 719 VAL A 726 ALA A 743 LYS A 745 LEU A 788 MET A 790 LEU A 792 MET A 793 GLY A 796 ASP A 800 LEU A 844	IRE A 1
4I22_A_IREA9001	4i22	IRE DB00317 (Gefitinib)	Homo sapiens	EPIDERMAL GROWTH FACTOR RECEPTOR	PF07714 (Pkinase_Tyr)	14	LEU A 718 GLY A 719 VAL A 726 ALA A 743 LYS A 745 LEU A 788 MET A 790 LEU A 792 MET A 793 GLY A 796 ASP A 800 LEU A 844 THR A 854 ASP A 855	IRE A9001
4WKQ_A_IREA1101	4wkq	IRE DB00317 (Gefitinib)	Homo sapiens	EPIDERMAL GROWTH FACTOR RECEPTOR	PF07714 (Pkinase_Tyr)	14	LEU A 718 ALA A 743 LYS A 745 GLU A 762 MET A 766 LEU A 788 THR A 790 LEU A 792 MET A 793 GLY A 796 ASP A 800 LEU A 844 THR A 854 ASP A 855	IRE A1101
5Y7Z_A_IREA401	5y7z	IRE DB00317 (Gefitinib)	Homo sapiens	CYCLIN-G-ASSOCIATED KINASE	PF00069 (Pkinase)	14	ARG A 44 LEU A 46 VAL A 54 ALA A 67 LYS A 69 GLU A 85 LEU A 125 CYS A 126 GLY A 128 GLN A 129 GLU A 132 LEU A 180 CYS A 190 ASP A 191	IRE A 401
5Y7Z_B_IREB401	5y7z	IRE DB00317 (Gefitinib)	Homo sapiens	CYCLIN-G-ASSOCIATED KINASE	None	13	LEU B 46 ALA B 67 LYS B 69 GLU B 85 LEU B 121 THR B 123 LEU B 125 CYS B 126 GLY B 128 GLU B 132 LEU B 180 CYS B 190 ASP B 191	IRE B 401
5Y80_A_IREA401	5y80	IRE DB00317 (Gefitinib)	Homo sapiens	CYCLIN-G-ASSOCIATED KINASE	PF00069 (Pkinase)	12	LEU A 46 VAL A 54 ALA A 67 LYS A 69 GLU A 85 THR A 123 LEU A 125 CYS A 126 GLY A 128 GLN A 129 LEU A 180 ASP A 191	IRE A 401
5Y80_A_IREA402	5y80	IRE DB00317 (Gefitinib)	Homo sapiens	CYCLIN-G-ASSOCIATED KINASE	PF00069 (Pkinase)	11	ALA A 81 ARG A 172 ASP A 173 SER A 194 HIS A 200 VAL A 214 ILE A 218 ASN A 221 THR A 222 ILE A 240 GLN A 244	IRE A 402

[["2ITO_A_IREA2020","2ito","IRE","DB00317(Gefitinib)","Homo sapiens","EPIDERMAL GROWTH FACTOR RECEPTOR","PF07714(Pkinase_Tyr)",13,"LEU A 718;SER A 719;ALA A 743;LYS A 745;GLU A 762;MET A 766;LEU A 788;THR A 790;MET A 793;GLY A 796;ASP A 800;LEU A 844;THR A 854","IRE A2020\r"],["2ITY_A_IREA2020","2ity","IRE","DB00317(Gefitinib)","Homo sapiens","EPIDERMAL GROWTH FACTOR RECEPTOR","PF07714(Pkinase_Tyr)",13,"LEU A 718;GLY A 719;VAL A 726;ALA A 743;LYS A 745;GLU A 762;MET A 766;LEU A 788;THR A 790;MET A 793;GLY A 796;LEU A 844;ASP A 855","IRE A2020\r"],["2ITZ_A_IREA2021","2itz","IRE","DB00317(Gefitinib)","Homo sapiens","EPIDERMAL GROWTH FACTOR RECEPTOR","PF07714(Pkinase_Tyr)",15,"LEU A 718;VAL A 726;ALA A 743;LYS A 745;GLU A 762;MET A 766;LEU A 788;THR A 790;LEU A 792;MET A 793;GLY A 796;ASP A 800;LEU A 844;THR A 854;ASP A 855","IRE A2021\r"],["3UG2_A_IREA1","3ug2","IRE","DB00317(Gefitinib)","Homo sapiens","EPIDERMAL GROWTH FACTOR RECEPTOR","PF07714(Pkinase_Tyr)",12,"LEU A 718;SER A 719;VAL A 726;ALA A 743;LYS A 745;LEU A 788;MET A 790;LEU A 792;MET A 793;GLY A 796;ASP A 800;LEU A 844","IRE A   1\r"],["4I22_A_IREA9001","4i22","IRE","DB00317(Gefitinib)","Homo sapiens","EPIDERMAL GROWTH FACTOR RECEPTOR","PF07714(Pkinase_Tyr)",14,"LEU A 718;GLY A 719;VAL A 726;ALA A 743;LYS A 745;LEU A 788;MET A 790;LEU A 792;MET A 793;GLY A 796;ASP A 800;LEU A 844;THR A 854;ASP A 855","IRE A9001\r"],["4WKQ_A_IREA1101","4wkq","IRE","DB00317(Gefitinib)","Homo sapiens","EPIDERMAL GROWTH FACTOR RECEPTOR","PF07714(Pkinase_Tyr)",14,"LEU A 718;ALA A 743;LYS A 745;GLU A 762;MET A 766;LEU A 788;THR A 790;LEU A 792;MET A 793;GLY A 796;ASP A 800;LEU A 844;THR A 854;ASP A 855","IRE A1101\r"],["5Y7Z_A_IREA401","5y7z","IRE","DB00317(Gefitinib)","Homo sapiens","CYCLIN-G-ASSOCIATED KINASE","PF00069(Pkinase)",14,"ARG A  44;LEU A  46;VAL A  54;ALA A  67;LYS A  69;GLU A  85;LEU A 125;CYS A 126;GLY A 128;GLN A 129;GLU A 132;LEU A 180;CYS A 190;ASP A 191","IRE A 401\r"],["5Y7Z_B_IREB401","5y7z","IRE","DB00317(Gefitinib)","Homo sapiens","CYCLIN-G-ASSOCIATED KINASE","None",13,"LEU B  46;ALA B  67;LYS B  69;GLU B  85;LEU B 121;THR B 123;LEU B 125;CYS B 126;GLY B 128;GLU B 132;LEU B 180;CYS B 190;ASP B 191","IRE B 401\r"],["5Y80_A_IREA401","5y80","IRE","DB00317(Gefitinib)","Homo sapiens","CYCLIN-G-ASSOCIATED KINASE","PF00069(Pkinase)",12,"LEU A  46;VAL A  54;ALA A  67;LYS A  69;GLU A  85;THR A 123;LEU A 125;CYS A 126;GLY A 128;GLN A 129;LEU A 180;ASP A 191","IRE A 401\r"],["5Y80_A_IREA402","5y80","IRE","DB00317(Gefitinib)","Homo sapiens","CYCLIN-G-ASSOCIATED KINASE","PF00069(Pkinase)",11,"ALA A  81;ARG A 172;ASP A 173;SER A 194;HIS A 200;VAL A 214;ILE A 218;ASN A 221;THR A 222;ILE A 240;GLN A 244","IRE A 402\r"]]