DRUG BINDING INTERFACES MAPPED TO 'HIS'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
1HTT_A_HISA450 1htt HIS

DB00117
(L-
Histidine) 		Escherichia
coli 		HISTIDYL-TRNA
SYNTHETASE 		PF03129
(tRNA-synt_His)
PF13393
(HGTP_anticodon) 		10 GLU A  83
THR A  85
TYR A 107
ARG A 113
GLN A 127
GLU A 131
ARG A 259
TYR A 263
TYR A 264
GLY A 285
 HIS A 450
1HTT_B_HISB450 1htt HIS

DB00117
(L-
Histidine) 		Escherichia
coli 		HISTIDYL-TRNA
SYNTHETASE 		None 12 GLU B  83
THR B  85
ARG B 113
GLN B 127
GLU B 131
ARG B 259
LEU B 261
TYR B 263
TYR B 264
GLY B 285
TYR B 288
GLY B 304
 HIS B 450
1HTT_C_HISC450 1htt HIS

DB00117
(L-
Histidine) 		Escherichia
coli 		HISTIDYL-TRNA
SYNTHETASE 		None 12 GLU C  83
THR C  85
GLN C 127
GLU C 131
ARG C 259
LEU C 261
TYR C 263
TYR C 264
GLY C 285
TYR C 288
GLY C 304
ALA C 306
 HIS C 450
1HTT_D_HISD450 1htt HIS

DB00117
(L-
Histidine) 		Escherichia
coli 		HISTIDYL-TRNA
SYNTHETASE 		None 12 GLU D  83
THR D  85
ARG D 113
GLN D 127
GLU D 131
ARG D 259
LEU D 261
TYR D 263
TYR D 264
GLY D 285
GLY D 304
ALA D 306
 HIS D 450
1NH8_A_HISA289 1nh8 HIS

DB00117
(L-
Histidine) 		Mycobacterium
tuberculosis 		ATP
PHOSPHORIBOSYLTRANSF
ERASE 		PF01634
(HisG_C)
PF08029
(HisG) 		5 ASP A 216
ASP A 218
LEU A 242
ALA A 273
LEU A 275
 HIS A 289
1WMQ_A_HISA2001 1wmq HIS

DB00117
(L-
Histidine) 		Bacillus
subtilis 		HUT OPERON POSITIVE
REGULATORY PROTEIN 		PF09021
(HutP) 		6 ARG A  88
ARG A  98
ILE A 129
GLY A 130
ALA A 131
HIS A 138
 HIS A2001
1WMQ_B_HISB1001 1wmq HIS

DB00117
(L-
Histidine) 		Bacillus
subtilis 		HUT OPERON POSITIVE
REGULATORY PROTEIN 		None 6 ARG B  88
ARG B  98
ILE B 129
GLY B 130
ALA B 131
HIS B 138
 HIS B1001
1WPU_A_HISA2001 1wpu HIS

DB00117
(L-
Histidine) 		Bacillus
subtilis 		HUT OPERON POSITIVE
REGULATORY PROTEIN 		PF09021
(HutP) 		6 ARG A  88
ARG A  98
ILE A 129
GLY A 130
ALA A 131
HIS A 138
 HIS A2001
1WPU_B_HISB1001 1wpu HIS

DB00117
(L-
Histidine) 		Bacillus
subtilis 		HUT OPERON POSITIVE
REGULATORY PROTEIN 		None 6 ARG B  88
ARG B  98
ILE B 129
GLY B 130
ALA B 131
HIS B 138
 HIS B1001
1WRQ_A_HISA2001 1wrq HIS

DB00117
(L-
Histidine) 		Bacillus
subtilis 		HUT OPERON POSITIVE
REGULATORY PROTEIN 		PF09021
(HutP) 		6 ARG A  88
ARG A  98
ILE A 129
GLY A 130
ALA A 131
HIS A 138
 HIS A2001
1WRQ_B_HISB1001 1wrq HIS

DB00117
(L-
Histidine) 		Bacillus
subtilis 		HUT OPERON POSITIVE
REGULATORY PROTEIN 		None 6 ARG B  88
ARG B  98
ILE B 129
GLY B 130
ALA B 131
HIS B 138
 HIS B1001
3BOY_A_HISA1001 3boy HIS

DB00117
(L-
Histidine) 		Bacillus
subtilis 		HUT OPERON POSITIVE
REGULATORY PROTEIN 		None
PF09021
(HutP) 		10 TYR C  69
HIS C  73
TYR C  76
HIS C  77
ARG A  88
ARG A  98
ILE A 129
GLY A 130
ALA A 131
HIS A 138
 HIS A1001
3BOY_A_HISA2001 3boy HIS

DB00117
(L-
Histidine) 		Bacillus
subtilis 		HUT OPERON POSITIVE
REGULATORY PROTEIN 		None
PF09021
(HutP) 		10 TYR A  69
HIS A  73
TYR A  76
HIS A  77
ARG B  88
ARG B  98
ILE B 129
GLY B 130
ALA B 131
HIS B 138
 HIS A2001
3BOY_A_HISA3001 3boy HIS

DB00117
(L-
Histidine) 		Bacillus
subtilis 		HUT OPERON POSITIVE
REGULATORY PROTEIN 		None
PF09021
(HutP) 		10 TYR B  69
HIS B  73
TYR B  76
HIS B  77
ARG C  88
ARG C  98
ILE C 129
GLY C 130
ALA C 131
HIS C 138
 HIS A3001
4RDX_A_HISA502 4rdx HIS

DB00117
(L-
Histidine) 		Thermus
thermophilus 		HISTIDINE--TRNA
LIGASE 		PF03129
(tRNA-synt_His)
PF13393
(HGTP_anticodon) 		7 THR A  83
GLU A 130
ARG A 259
TYR A 264
GLY A 285
TYR A 288
GLY A 304
 HIS A 502
4YB6_A_HISA302 4yb6 HIS

DB00117
(L-
Histidine) 		Campylobacter
jejuni 		ATP
PHOSPHORIBOSYLTRANSF
ERASE 		None
PF01634
(HisG)
PF08029
(HisG_C) 		10 MET E 230
HIS E 232
GLY A 247
VAL A 248
GLU A 249
THR A 252
LEU E 256
VAL A 268
SER E 288
LEU E 290
 HIS A 302
4YB6_B_HISB302 4yb6 HIS

DB00117
(L-
Histidine) 		Campylobacter
jejuni 		ATP
PHOSPHORIBOSYLTRANSF
ERASE 		None 10 MET C 230
HIS C 232
GLY B 247
VAL B 248
GLU B 249
THR B 252
LEU C 256
VAL B 268
SER C 288
LEU C 290
 HIS B 302
4YB6_C_HISC302 4yb6 HIS

DB00117
(L-
Histidine) 		Campylobacter
jejuni 		ATP
PHOSPHORIBOSYLTRANSF
ERASE 		None 10 MET F 230
HIS F 232
GLY C 247
VAL C 248
GLU C 249
THR C 252
LEU F 256
VAL C 268
SER F 288
LEU F 290
 HIS C 302
4YB6_D_HISD302 4yb6 HIS

DB00117
(L-
Histidine) 		Campylobacter
jejuni 		ATP
PHOSPHORIBOSYLTRANSF
ERASE 		None
PF01634
(HisG)
PF08029
(HisG_C) 		10 MET A 230
HIS A 232
GLY D 247
VAL D 248
GLU D 249
THR D 252
LEU A 256
VAL D 268
SER A 288
LEU A 290
 HIS D 302
4YB6_E_HISE302 4yb6 HIS

DB00117
(L-
Histidine) 		Campylobacter
jejuni 		ATP
PHOSPHORIBOSYLTRANSF
ERASE 		None 10 MET D 230
HIS D 232
GLY E 247
VAL E 248
GLU E 249
THR E 252
LEU D 256
VAL E 268
SER D 288
LEU D 290
 HIS E 302
4YB6_F_HISF302 4yb6 HIS

DB00117
(L-
Histidine) 		Campylobacter
jejuni 		ATP
PHOSPHORIBOSYLTRANSF
ERASE 		None 10 MET B 230
HIS B 232
GLY F 247
VAL F 248
GLU F 249
THR F 252
LEU B 256
VAL F 268
SER B 288
LEU B 290
 HIS F 302
5E3I_A_HISA502 5e3i HIS

DB00117
(L-
Histidine) 		Acinetobacter
baumannii 		HISTIDINE--TRNA
LIGASE 		PF03129
(tRNA-synt_His)
PF13393
(HGTP_anticodon) 		12 GLU A  85
THR A  87
ARG A 115
GLN A 129
GLU A 133
LEU A 263
TYR A 265
TYR A 266
GLY A 287
TYR A 290
GLY A 309
ALA A 311
 HIS A 502
5E3I_B_HISB502 5e3i HIS

DB00117
(L-
Histidine) 		Acinetobacter
baumannii 		HISTIDINE--TRNA
LIGASE 		None 11 GLU B  85
THR B  87
ARG B 115
GLN B 129
GLU B 133
TYR B 265
TYR B 266
GLY B 287
TYR B 290
GLY B 309
ALA B 311
 HIS B 502
6AN0_A_HISA520 6an0 HIS

DB00117
(L-
Histidine) 		Elizabethkingia
anophelis 		HISTIDINOL
DEHYDROGENASE 		PF00815
(Histidinol_dh) 		6 GLU A  98
LYS A 100
ARG A 113
GLU A 114
ALA A 115
LYS A 385
 HIS A 520
6CZM_A_HISA402 6czm HIS

DB00117
(L-
Histidine) 		Medicago
truncatula 		ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT 		None
PF01634
(HisG_C)
PF08029
(HisG) 		10 VAL C 277
ASN C 279
GLY A 300
LEU A 301
THR A 305
VAL C 309
ALA C 323
VAL A 325
CYS A 327
LEU C 349
 HIS A 402
6CZM_B_HISB402 6czm HIS

DB00117
(L-
Histidine) 		Medicago
truncatula 		ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT 		None
PF01634
(HisG_C)
PF08029
(HisG) 		9 VAL A 277
ASN A 279
GLY B 300
LEU B 301
GLN B 302
THR B 305
VAL A 309
VAL B 325
LEU A 349
 HIS B 402
6CZM_C_HISC402 6czm HIS

DB00117
(L-
Histidine) 		Medicago
truncatula 		ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT 		None 9 VAL B 277
ASN B 279
GLY C 300
LEU C 301
GLN C 302
THR C 305
VAL B 309
VAL C 325
LEU B 349
 HIS C 402
6CZM_D_HISD402 6czm HIS

DB00117
(L-
Histidine) 		Medicago
truncatula 		ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT 		None 8 VAL F 277
ASN F 279
GLY D 300
LEU D 301
GLN D 302
THR D 305
VAL F 309
LEU F 349
 HIS D 402
6CZM_E_HISE402 6czm HIS

DB00117
(L-
Histidine) 		Medicago
truncatula 		ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT 		None 9 VAL D 277
ASN D 279
GLY E 300
LEU E 301
THR E 305
VAL D 309
VAL E 325
CYS E 327
LEU D 349
 HIS E 402
6CZM_F_HISF402 6czm HIS

DB00117
(L-
Histidine) 		Medicago
truncatula 		ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT 		None 10 VAL E 277
ASN E 279
GLY F 300
LEU F 301
GLN F 302
THR F 305
VAL E 309
VAL F 325
CYS F 327
LEU E 349
 HIS F 402