DRUG BINDING INTERFACES MAPPED TO 'FFO'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)

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DrReposER ID	PDB	Ligand	Organism	Macromolecule	Pfam	Res.	Interface	HETATM
1DFO_A_FFOA1002	1dfo	FFO DB11596 (Levoleucovorin)	Escherichia coli	SERINE HYDROXYMETHYLTRANSFE RASE	None PF00464 (SHMT)	20	GLU B 57 TYR B 64 TYR B 65 LEU A 121 GLY A 124 HIS A 126 LEU A 127 VAL A 133 SER A 175 ALA A 176 SER D 245 GLU D 246 GLU D 247 PHE B 257 PRO B 258 ASN A 347 SER A 355 PRO A 356 PHE A 357 ARG A 363	FFO A1002
1DFO_B_FFOB2002	1dfo	FFO DB11596 (Levoleucovorin)	Escherichia coli	SERINE HYDROXYMETHYLTRANSFE RASE	None PF00464 (SHMT)	17	GLU A 57 TYR A 64 TYR A 65 LEU B 121 GLY B 124 HIS B 126 LEU B 127 VAL B 133 SER B 175 ALA B 176 PHE A 257 PRO A 258 ASN B 347 SER B 355 PRO B 356 PHE B 357 ARG B 363	FFO B2002
1DFO_C_FFOC3002	1dfo	FFO DB11596 (Levoleucovorin)	Escherichia coli	SERINE HYDROXYMETHYLTRANSFE RASE	None	20	GLU D 57 TYR D 64 TYR D 65 LEU C 121 GLY C 124 HIS C 126 LEU C 127 VAL C 133 SER C 175 ALA C 176 SER B 245 GLU B 246 GLU B 247 PHE D 257 PRO D 258 ASN C 347 SER C 355 PRO C 356 PHE C 357 ARG C 363	FFO C3002
1DFO_D_FFOD4002	1dfo	FFO DB11596 (Levoleucovorin)	Escherichia coli	SERINE HYDROXYMETHYLTRANSFE RASE	None	17	GLU C 57 TYR C 64 TYR C 65 LEU D 121 GLY D 124 HIS D 126 LEU D 127 VAL D 133 SER D 175 ALA D 176 PHE C 257 PRO C 258 ASN D 347 SER D 355 PRO D 356 PHE D 357 ARG D 363	FFO D4002
1EQB_A_FFOA1293	1eqb	FFO DB11596 (Levoleucovorin)	Escherichia coli	SERINE HYDROXYMETHYLTRANSFE RASE	None PF00464 (SHMT)	18	GLU B 57 TYR B 64 LEU A 121 GLY A 124 HIS A 126 LEU A 127 VAL A 133 SER A 175 ALA A 176 SER D 245 GLU D 246 GLU D 247 PHE B 257 ASN A 347 SER A 355 PRO A 356 PHE A 357 ARG A 363	FFO A1293
1EQB_B_FFOB2293	1eqb	FFO DB11596 (Levoleucovorin)	Escherichia coli	SERINE HYDROXYMETHYLTRANSFE RASE	None PF00464 (SHMT)	15	GLU A 57 TYR A 64 LEU B 121 GLY B 124 HIS B 126 LEU B 127 VAL B 133 SER B 175 ALA B 176 PHE A 257 ASN B 347 SER B 355 PRO B 356 PHE B 357 ARG B 363	FFO B2293
1EQB_C_FFOC3293	1eqb	FFO DB11596 (Levoleucovorin)	Escherichia coli	SERINE HYDROXYMETHYLTRANSFE RASE	None	18	GLU D 57 TYR D 64 LEU C 121 GLY C 124 HIS C 126 LEU C 127 VAL C 133 SER C 175 ALA C 176 SER B 245 GLU B 246 GLU B 247 PHE D 257 ASN C 347 SER C 355 PRO C 356 PHE C 357 ARG C 363	FFO C3293
1EQB_D_FFOD4293	1eqb	FFO DB11596 (Levoleucovorin)	Escherichia coli	SERINE HYDROXYMETHYLTRANSFE RASE	None	15	GLU C 57 TYR C 64 LEU D 121 GLY D 124 HIS D 126 LEU D 127 VAL D 133 SER D 175 ALA D 176 PHE C 257 ASN D 347 SER D 355 PRO D 356 PHE D 357 ARG D 363	FFO D4293
1JOL_A_FFOA161	1jol	FFO DB11596 (Levoleucovorin)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	13	ILE A 5 ALA A 7 ASP A 27 LEU A 28 TRP A 30 PHE A 31 LYS A 32 ILE A 50 ARG A 52 LEU A 54 ARG A 57 TYR A 100 THR A 113	FFO A 161
1JOL_B_FFOB361	1jol	FFO DB11596 (Levoleucovorin)	Escherichia coli	DIHYDROFOLATE REDUCTASE	None	13	ILE B 5 ALA B 7 ASP B 27 LEU B 28 PHE B 31 LYS B 32 ILE B 50 ARG B 52 LEU B 54 PRO B 55 ARG B 57 TYR B 100 THR B 113	FFO B 361
1JOM_A_FFOA161	1jom	FFO DB11596 (Levoleucovorin)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	11	ALA A 7 GLU A 17 ASP A 27 LEU A 28 PHE A 31 LYS A 32 ILE A 50 LEU A 54 ARG A 57 TYR A 100 THR A 113	FFO A 161
1PJ7_A_FFOA2887	1pj7	FFO DB11596 (Levoleucovorin)	Arthrobacter globiformis	N,N-DIMETHYLGLYCINE OXIDASE	PF01266 (GCV_T_C) PF01571 (GCV_T) PF08669 (FAO_M) PF16350 (DAO)	15	MET A 505 LEU A 508 TYR A 539 ASP A 552 THR A 554 GLY A 566 ASN A 568 TYR A 631 PHE A 632 LEU A 649 TYR A 651 GLU A 658 TYR A 660 TYR A 699 PHE A 719	FFO A2887
1WOP_A_FFOA2887	1wop	FFO DB11596 (Levoleucovorin)	Thermotoga maritima	AMINOMETHYLTRANSFERA SE	PF01571 (GCV_T) PF08669 (GCV_T_C)	15	MET A 51 TYR A 83 ASP A 96 VAL A 98 TYR A 100 VAL A 110 ASN A 112 TYR A 168 TYR A 169 TYR A 188 GLU A 195 ARG A 227 TYR A 236 TRP A 256 ARG A 362	FFO A2887
1WOP_A_FFOA2888	1wop	FFO DB11596 (Levoleucovorin)	Thermotoga maritima	AMINOMETHYLTRANSFERA SE	PF01571 (GCV_T) PF08669 (GCV_T_C)	10	LEU A 55 GLU A 106 LEU A 108 ILE A 137 GLU A 160 LYS A 173 ILE A 175 GLU A 180 LEU A 182 MET A 197	FFO A2888
2VMY_A_FFOA505	2vmy	FFO DB11596 (Levoleucovorin)	Geobacillus stearothermophi lus	SERINE HYDROXYMETHYLTRANSFE RASE	None PF00464 (SHMT)	18	GLU A 53 TYR A 60 TYR A 61 LEU B 117 GLY B 120 HIS B 122 LEU B 123 VAL B 129 SER B 172 ALA B 173 LYS A 248 PHE A 251 PRO A 252 ASN B 341 SER B 349 PRO B 350 GLY B 351 ARG B 357	FFO A 505
2VMY_B_FFOB505	2vmy	FFO DB11596 (Levoleucovorin)	Geobacillus stearothermophi lus	SERINE HYDROXYMETHYLTRANSFE RASE	None PF00464 (SHMT)	17	GLU B 53 TYR B 60 TYR B 61 LEU A 117 GLY A 120 HIS A 122 LEU A 123 VAL A 129 SER A 172 ALA A 173 PHE B 251 ASN A 339 ASN A 341 SER A 349 PRO A 350 GLY A 351 ARG A 357	FFO B 505
6R2E_A_FFOA403	6r2e	FFO DB11596 (Levoleucovorin)	Homo sapiens	THYMIDYLATE SYNTHASE	PF00303 (Thymidylat_synt)	12	PHE A 80 ILE A 108 TRP A 109 ASN A 112 LEU A 192 ASP A 218 LEU A 221 GLY A 222 PHE A 225 ASN A 226 TYR A 258 MET A 311	FFO A 403
6R2E_B_FFOB403	6r2e	FFO DB11596 (Levoleucovorin)	Homo sapiens	THYMIDYLATE SYNTHASE	None	10	PHE B 80 ILE B 108 TRP B 109 ASN B 112 LEU B 192 ASP B 218 LEU B 221 GLY B 222 ASN B 226 MET B 311	FFO B 403
6R2E_C_FFOC404	6r2e	FFO DB11596 (Levoleucovorin)	Homo sapiens	THYMIDYLATE SYNTHASE	None	10	PHE C 80 ILE C 108 TRP C 109 ASN C 112 LEU C 192 ASP C 218 LEU C 221 GLY C 222 ASN C 226 MET C 311	FFO C 404
6R2E_D_FFOD403	6r2e	FFO DB11596 (Levoleucovorin)	Homo sapiens	THYMIDYLATE SYNTHASE	None	10	PHE D 80 ILE D 108 TRP D 109 ASN D 112 LEU D 192 ASP D 218 LEU D 221 GLY D 222 ASN D 226 MET D 311	FFO D 403
6R2E_E_FFOE403	6r2e	FFO DB11596 (Levoleucovorin)	Homo sapiens	THYMIDYLATE SYNTHASE	PF00303 (Thymidylat_synt)	13	PHE E 80 ILE E 108 TRP E 109 ASN E 112 TYR E 135 LEU E 192 ASP E 218 LEU E 221 GLY E 222 PHE E 225 ASN E 226 MET E 311 ALA E 312	FFO E 403
6R2E_F_FFOF403	6r2e	FFO DB11596 (Levoleucovorin)	Homo sapiens	THYMIDYLATE SYNTHASE	None	11	PHE F 80 ILE F 108 TRP F 109 ASN F 112 LEU F 192 ASP F 218 LEU F 221 GLY F 222 ASN F 226 MET F 311 ALA F 312	FFO F 403
6R2E_G_FFOG403	6r2e	FFO DB11596 (Levoleucovorin)	Homo sapiens	THYMIDYLATE SYNTHASE	None	11	PHE G 80 ILE G 108 TRP G 109 ASN G 112 LEU G 192 ASP G 218 LEU G 221 GLY G 222 PHE G 225 ASN G 226 MET G 311	FFO G 403
6R2E_H_FFOH403	6r2e	FFO DB11596 (Levoleucovorin)	Homo sapiens	THYMIDYLATE SYNTHASE	None	12	PHE H 80 ILE H 108 TRP H 109 ASN H 112 TYR H 135 LEU H 192 ASP H 218 LEU H 221 GLY H 222 ASN H 226 MET H 311 ALA H 312	FFO H 403

[["1DFO_A_FFOA1002","1dfo","FFO","DB11596(Levoleucovorin)","Escherichia coli","SERINE HYDROXYMETHYLTRANSFERASE","None;PF00464(SHMT)",20,"GLU B  57;TYR B  64;TYR B  65;LEU A 121;GLY A 124;HIS A 126;LEU A 127;VAL A 133;SER A 175;ALA A 176;SER D 245;GLU D 246;GLU D 247;PHE B 257;PRO B 258;ASN A 347;SER A 355;PRO A 356;PHE A 357;ARG A 363","FFO A1002\r"],["1DFO_B_FFOB2002","1dfo","FFO","DB11596(Levoleucovorin)","Escherichia coli","SERINE HYDROXYMETHYLTRANSFERASE","None;PF00464(SHMT)",17,"GLU A  57;TYR A  64;TYR A  65;LEU B 121;GLY B 124;HIS B 126;LEU B 127;VAL B 133;SER B 175;ALA B 176;PHE A 257;PRO A 258;ASN B 347;SER B 355;PRO B 356;PHE B 357;ARG B 363","FFO B2002\r"],["1DFO_C_FFOC3002","1dfo","FFO","DB11596(Levoleucovorin)","Escherichia coli","SERINE HYDROXYMETHYLTRANSFERASE","None",20,"GLU D  57;TYR D  64;TYR D  65;LEU C 121;GLY C 124;HIS C 126;LEU C 127;VAL C 133;SER C 175;ALA C 176;SER B 245;GLU B 246;GLU B 247;PHE D 257;PRO D 258;ASN C 347;SER C 355;PRO C 356;PHE C 357;ARG C 363","FFO C3002\r"],["1DFO_D_FFOD4002","1dfo","FFO","DB11596(Levoleucovorin)","Escherichia coli","SERINE HYDROXYMETHYLTRANSFERASE","None",17,"GLU C  57;TYR C  64;TYR C  65;LEU D 121;GLY D 124;HIS D 126;LEU D 127;VAL D 133;SER D 175;ALA D 176;PHE C 257;PRO C 258;ASN D 347;SER D 355;PRO D 356;PHE D 357;ARG D 363","FFO D4002\r"],["1EQB_A_FFOA1293","1eqb","FFO","DB11596(Levoleucovorin)","Escherichia coli","SERINE HYDROXYMETHYLTRANSFERASE","None;PF00464(SHMT)",18,"GLU B  57;TYR B  64;LEU A 121;GLY A 124;HIS A 126;LEU A 127;VAL A 133;SER A 175;ALA A 176;SER D 245;GLU D 246;GLU D 247;PHE B 257;ASN A 347;SER A 355;PRO A 356;PHE A 357;ARG A 363","FFO A1293\r"],["1EQB_B_FFOB2293","1eqb","FFO","DB11596(Levoleucovorin)","Escherichia coli","SERINE HYDROXYMETHYLTRANSFERASE","None;PF00464(SHMT)",15,"GLU A  57;TYR A  64;LEU B 121;GLY B 124;HIS B 126;LEU B 127;VAL B 133;SER B 175;ALA B 176;PHE A 257;ASN B 347;SER B 355;PRO B 356;PHE B 357;ARG B 363","FFO B2293\r"],["1EQB_C_FFOC3293","1eqb","FFO","DB11596(Levoleucovorin)","Escherichia coli","SERINE HYDROXYMETHYLTRANSFERASE","None",18,"GLU D  57;TYR D  64;LEU C 121;GLY C 124;HIS C 126;LEU C 127;VAL C 133;SER C 175;ALA C 176;SER B 245;GLU B 246;GLU B 247;PHE D 257;ASN C 347;SER C 355;PRO C 356;PHE C 357;ARG C 363","FFO C3293\r"],["1EQB_D_FFOD4293","1eqb","FFO","DB11596(Levoleucovorin)","Escherichia coli","SERINE HYDROXYMETHYLTRANSFERASE","None",15,"GLU C  57;TYR C  64;LEU D 121;GLY D 124;HIS D 126;LEU D 127;VAL D 133;SER D 175;ALA D 176;PHE C 257;ASN D 347;SER D 355;PRO D 356;PHE D 357;ARG D 363","FFO D4293\r"],["1JOL_A_FFOA161","1jol","FFO","DB11596(Levoleucovorin)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",13,"ILE A   5;ALA A   7;ASP A  27;LEU A  28;TRP A  30;PHE A  31;LYS A  32;ILE A  50;ARG A  52;LEU A  54;ARG A  57;TYR A 100;THR A 113","FFO A 161\r"],["1JOL_B_FFOB361","1jol","FFO","DB11596(Levoleucovorin)","Escherichia coli","DIHYDROFOLATE REDUCTASE","None",13,"ILE B   5;ALA B   7;ASP B  27;LEU B  28;PHE B  31;LYS B  32;ILE B  50;ARG B  52;LEU B  54;PRO B  55;ARG B  57;TYR B 100;THR B 113","FFO B 361\r"],["1JOM_A_FFOA161","1jom","FFO","DB11596(Levoleucovorin)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",11,"ALA A   7;GLU A  17;ASP A  27;LEU A  28;PHE A  31;LYS A  32;ILE A  50;LEU A  54;ARG A  57;TYR A 100;THR A 113","FFO A 161\r"],["1PJ7_A_FFOA2887","1pj7","FFO","DB11596(Levoleucovorin)","Arthrobacter globiformis","N,N-DIMETHYLGLYCINE OXIDASE","PF01266(GCV_T_C);PF01571(GCV_T);PF08669(FAO_M);PF16350(DAO)",15,"MET A 505;LEU A 508;TYR A 539;ASP A 552;THR A 554;GLY A 566;ASN A 568;TYR A 631;PHE A 632;LEU A 649;TYR A 651;GLU A 658;TYR A 660;TYR A 699;PHE A 719","FFO A2887\r"],["1WOP_A_FFOA2887","1wop","FFO","DB11596(Levoleucovorin)","Thermotoga maritima","AMINOMETHYLTRANSFERASE","PF01571(GCV_T);PF08669(GCV_T_C)",15,"MET A  51;TYR A  83;ASP A  96;VAL A  98;TYR A 100;VAL A 110;ASN A 112;TYR A 168;TYR A 169;TYR A 188;GLU A 195;ARG A 227;TYR A 236;TRP A 256;ARG A 362","FFO A2887\r"],["1WOP_A_FFOA2888","1wop","FFO","DB11596(Levoleucovorin)","Thermotoga maritima","AMINOMETHYLTRANSFERASE","PF01571(GCV_T);PF08669(GCV_T_C)",10,"LEU A  55;GLU A 106;LEU A 108;ILE A 137;GLU A 160;LYS A 173;ILE A 175;GLU A 180;LEU A 182;MET A 197","FFO A2888\r"],["2VMY_A_FFOA505","2vmy","FFO","DB11596(Levoleucovorin)","Geobacillus stearothermophilus","SERINE HYDROXYMETHYLTRANSFERASE","None;PF00464(SHMT)",18,"GLU A  53;TYR A  60;TYR A  61;LEU B 117;GLY B 120;HIS B 122;LEU B 123;VAL B 129;SER B 172;ALA B 173;LYS A 248;PHE A 251;PRO A 252;ASN B 341;SER B 349;PRO B 350;GLY B 351;ARG B 357","FFO A 505\r"],["2VMY_B_FFOB505","2vmy","FFO","DB11596(Levoleucovorin)","Geobacillus stearothermophilus","SERINE HYDROXYMETHYLTRANSFERASE","None;PF00464(SHMT)",17,"GLU B  53;TYR B  60;TYR B  61;LEU A 117;GLY A 120;HIS A 122;LEU A 123;VAL A 129;SER A 172;ALA A 173;PHE B 251;ASN A 339;ASN A 341;SER A 349;PRO A 350;GLY A 351;ARG A 357","FFO B 505\r"],["6R2E_A_FFOA403","6r2e","FFO","DB11596(Levoleucovorin)","Homo sapiens","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",12,"PHE A  80;ILE A 108;TRP A 109;ASN A 112;LEU A 192;ASP A 218;LEU A 221;GLY A 222;PHE A 225;ASN A 226;TYR A 258;MET A 311","FFO A 403\r"],["6R2E_B_FFOB403","6r2e","FFO","DB11596(Levoleucovorin)","Homo sapiens","THYMIDYLATE SYNTHASE","None",10,"PHE B  80;ILE B 108;TRP B 109;ASN B 112;LEU B 192;ASP B 218;LEU B 221;GLY B 222;ASN B 226;MET B 311","FFO B 403\r"],["6R2E_C_FFOC404","6r2e","FFO","DB11596(Levoleucovorin)","Homo sapiens","THYMIDYLATE SYNTHASE","None",10,"PHE C  80;ILE C 108;TRP C 109;ASN C 112;LEU C 192;ASP C 218;LEU C 221;GLY C 222;ASN C 226;MET C 311","FFO C 404\r"],["6R2E_D_FFOD403","6r2e","FFO","DB11596(Levoleucovorin)","Homo sapiens","THYMIDYLATE SYNTHASE","None",10,"PHE D  80;ILE D 108;TRP D 109;ASN D 112;LEU D 192;ASP D 218;LEU D 221;GLY D 222;ASN D 226;MET D 311","FFO D 403\r"],["6R2E_E_FFOE403","6r2e","FFO","DB11596(Levoleucovorin)","Homo sapiens","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",13,"PHE E  80;ILE E 108;TRP E 109;ASN E 112;TYR E 135;LEU E 192;ASP E 218;LEU E 221;GLY E 222;PHE E 225;ASN E 226;MET E 311;ALA E 312","FFO E 403\r"],["6R2E_F_FFOF403","6r2e","FFO","DB11596(Levoleucovorin)","Homo sapiens","THYMIDYLATE SYNTHASE","None",11,"PHE F  80;ILE F 108;TRP F 109;ASN F 112;LEU F 192;ASP F 218;LEU F 221;GLY F 222;ASN F 226;MET F 311;ALA F 312","FFO F 403\r"],["6R2E_G_FFOG403","6r2e","FFO","DB11596(Levoleucovorin)","Homo sapiens","THYMIDYLATE SYNTHASE","None",11,"PHE G  80;ILE G 108;TRP G 109;ASN G 112;LEU G 192;ASP G 218;LEU G 221;GLY G 222;PHE G 225;ASN G 226;MET G 311","FFO G 403\r"],["6R2E_H_FFOH403","6r2e","FFO","DB11596(Levoleucovorin)","Homo sapiens","THYMIDYLATE SYNTHASE","None",12,"PHE H  80;ILE H 108;TRP H 109;ASN H 112;TYR H 135;LEU H 192;ASP H 218;LEU H 221;GLY H 222;ASN H 226;MET H 311;ALA H 312","FFO H 403\r"]]