DRUG BINDING INTERFACES MAPPED TO 'DB8'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)

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DrReposER ID	PDB	Ligand	Organism	Macromolecule	Pfam	Res.	Interface	HETATM
3SOA_A_DB8A445	3soa	DB8 DB06616 (Bosutinib)	Homo sapiens	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA WITH A BETA 7 LINKER	PF00069 (Pkinase) PF08332 (CaMKII_AD)	6	LEU A 19 VAL A 27 MET A 42 PHE A 89 VAL A 92 PHE A 157	DB8 A 445
3UE4_A_DB8A601	3ue4	DB8 DB06616 (Bosutinib)	Homo sapiens	TYROSINE-PROTEIN KINASE ABL1	PF07714 (Pkinase_Tyr)	12	LEU A 248 ALA A 269 LYS A 271 GLU A 286 VAL A 299 ILE A 313 THR A 315 PHE A 317 MET A 318 GLY A 321 LEU A 370 PHE A 382	DB8 A 601
3UE4_B_DB8B601	3ue4	DB8 DB06616 (Bosutinib)	Homo sapiens	TYROSINE-PROTEIN KINASE ABL1	no annotation	14	LEU B 248 VAL B 256 ALA B 269 LYS B 271 GLU B 286 MET B 290 VAL B 299 ILE B 313 THR B 315 PHE B 317 MET B 318 GLY B 321 LEU B 370 PHE B 382	DB8 B 601
4MXO_A_DB8A601	4mxo	DB8 DB06616 (Bosutinib)	Homo sapiens	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC	PF07714 (Pkinase_Tyr)	14	LEU A 273 VAL A 281 ALA A 293 LYS A 295 GLU A 310 MET A 314 VAL A 323 ILE A 336 THR A 338 TYR A 340 MET A 341 GLY A 344 LEU A 393 ASP A 404	DB8 A 601
4MXO_B_DB8B601	4mxo	DB8 DB06616 (Bosutinib)	Homo sapiens	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC	no annotation	13	LEU B 273 VAL B 281 ALA B 293 LYS B 295 GLU B 310 VAL B 323 ILE B 336 THR B 338 TYR B 340 MET B 341 GLY B 344 LEU B 393 ASP B 404	DB8 B 601
4MXX_A_DB8A601	4mxx	DB8 DB06616 (Bosutinib)	Homo sapiens	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC	PF07714 (Pkinase_Tyr)	13	LEU A 273 ALA A 293 LYS A 295 GLU A 310 MET A 314 VAL A 323 ILE A 336 THR A 338 TYR A 340 MET A 341 GLY A 344 LEU A 393 THR A 403	DB8 A 601
4MXX_B_DB8B601	4mxx	DB8 DB06616 (Bosutinib)	Homo sapiens	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC	no annotation	12	LEU B 273 VAL B 281 ALA B 293 LYS B 295 VAL B 323 THR B 338 TYR B 340 MET B 341 GLY B 344 LEU B 393 THR B 403 PHE B 405	DB8 B 601
4MXY_A_DB8A601	4mxy	DB8 DB06616 (Bosutinib)	Homo sapiens	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC	PF07714 (Pkinase_Tyr)	13	LEU A 273 VAL A 281 ALA A 293 LYS A 295 GLU A 310 VAL A 323 ILE A 336 MET A 338 TYR A 340 MET A 341 GLY A 344 LEU A 393 ASP A 404	DB8 A 601
4MXY_B_DB8B601	4mxy	DB8 DB06616 (Bosutinib)	Homo sapiens	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC	no annotation	13	LEU B 273 VAL B 281 ALA B 293 LYS B 295 GLU B 310 VAL B 323 MET B 338 TYR B 340 MET B 341 GLY B 344 LEU B 393 ALA B 403 ASP B 404	DB8 B 601
4MXZ_A_DB8A601	4mxz	DB8 DB06616 (Bosutinib)	Homo sapiens	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC	PF07714 (Pkinase_Tyr)	13	LEU A 273 VAL A 281 ALA A 293 LYS A 295 GLU A 310 VAL A 323 ILE A 336 MET A 338 TYR A 340 MET A 341 GLY A 344 LEU A 393 ASP A 404	DB8 A 601
4MXZ_B_DB8B601	4mxz	DB8 DB06616 (Bosutinib)	Homo sapiens	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC	no annotation	13	LEU B 273 VAL B 281 ALA B 293 LYS B 295 GLU B 310 VAL B 323 MET B 338 TYR B 340 MET B 341 GLY B 344 LEU B 393 ALA B 403 ASP B 404	DB8 B 601
4OTW_A_DB8A1101	4otw	DB8 DB06616 (Bosutinib)	Homo sapiens	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3	PF07714 (Pkinase_Tyr)	15	LEU A 696 VAL A 704 CYS A 721 LYS A 723 VAL A 753 LEU A 766 THR A 768 TYR A 770 LEU A 771 GLY A 774 ASN A 820 LEU A 822 ALA A 832 ASP A 833 VAL A 836	DB8 A1101
4QMN_A_DB8A401	4qmn	DB8 DB06616 (Bosutinib)	Homo sapiens	SERINE/THREONINE-PRO TEIN KINASE 24	PF00069 (Pkinase)	13	ILE A 30 ALA A 51 LYS A 53 GLU A 70 THR A 83 ILE A 97 MET A 99 TYR A 101 LEU A 102 LEU A 151 ALA A 161 ASP A 162 LYS A 295	DB8 A 401
5AJQ_A_DB8A800	5ajq	DB8 DB06616 (Bosutinib)	Homo sapiens	SERINE/THREONINE-PRO TEIN KINASE 10	PF00069 (Pkinase)	16	LEU A 42 GLY A 43 VAL A 50 ALA A 63 LYS A 65 ILE A 110 PHE A 112 CYS A 113 GLY A 116 GLU A 124 ASN A 162 LEU A 164 ALA A 174 ASP A 175 VAL A 178 SER A 179	DB8 A 800
5AJQ_B_DB8B800	5ajq	DB8 DB06616 (Bosutinib)	Homo sapiens	SERINE/THREONINE-PRO TEIN KINASE 10	no annotation	10	LEU B 42 ALA B 63 LYS B 65 ILE B 110 PHE B 112 CYS B 113 GLY B 116 LEU B 164 ALA B 174 ASP B 175	DB8 B 800
5I9X_A_DB8A1001	5i9x	DB8 DB06616 (Bosutinib)	Homo sapiens	EPHRIN TYPE-A RECEPTOR 2	PF07714 (Pkinase_Tyr)	13	ILE A 619 ALA A 644 LYS A 646 GLU A 663 ILE A 676 ILE A 690 THR A 692 TYR A 694 MET A 695 GLY A 698 GLU A 706 LEU A 746 SER A 756	DB8 A1001
5VC3_A_DB8A601	5vc3	DB8 DB06616 (Bosutinib)	Homo sapiens	WEE1-LIKE PROTEIN KINASE	PF00069 (Pkinase)	16	GLU A 303 ILE A 305 GLY A 306 VAL A 313 ALA A 326 LYS A 328 GLU A 346 VAL A 360 ASN A 376 TYR A 378 CYS A 379 GLY A 382 ASP A 386 ASN A 431 PHE A 433 ASP A 463	DB8 A 601
5VCY_A_DB8A401	5vcy	DB8 DB06616 (Bosutinib)	Homo sapiens	MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE	PF00069 (Pkinase)	16	LEU A 116 VAL A 124 ALA A 137 LYS A 139 GLU A 157 VAL A 171 LEU A 185 THR A 187 LEU A 189 CYS A 190 GLY A 191 PRO A 192 GLN A 196 ASN A 238 PHE A 240 ASP A 251	DB8 A 401
6FDY_U_DB8U301	6fdy	DB8 DB06616 (Bosutinib)	-	-	no annotation	11	LEU U 20 VAL U 28 ALA U 42 LYS U 44 VAL U 75 MET U 91 PHE U 93 CYS U 94 ASN U 142 LEU U 144 ASP U 157	DB8 U 301
6FDY_U_DB8U302	6fdy	DB8 DB06616 (Bosutinib)	-	-	no annotation	9	LEU U 173 PRO U 177 MET U 180 VAL U 185 PHE U 218 SER U 219 LEU U 221 GLU U 222 ILE U 225	DB8 U 302

[["3SOA_A_DB8A445","3soa","DB8","DB06616(Bosutinib)","Homo sapiens","CALCIUM\/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA WITH A BETA 7 LINKER","PF00069(Pkinase);PF08332(CaMKII_AD)",6,"LEU A  19;VAL A  27;MET A  42;PHE A  89;VAL A  92;PHE A 157","DB8 A 445\r"],["3UE4_A_DB8A601","3ue4","DB8","DB06616(Bosutinib)","Homo sapiens","TYROSINE-PROTEIN KINASE ABL1","PF07714(Pkinase_Tyr)",12,"LEU A 248;ALA A 269;LYS A 271;GLU A 286;VAL A 299;ILE A 313;THR A 315;PHE A 317;MET A 318;GLY A 321;LEU A 370;PHE A 382","DB8 A 601\r"],["3UE4_B_DB8B601","3ue4","DB8","DB06616(Bosutinib)","Homo sapiens","TYROSINE-PROTEIN KINASE ABL1","no annotation",14,"LEU B 248;VAL B 256;ALA B 269;LYS B 271;GLU B 286;MET B 290;VAL B 299;ILE B 313;THR B 315;PHE B 317;MET B 318;GLY B 321;LEU B 370;PHE B 382","DB8 B 601\r"],["4MXO_A_DB8A601","4mxo","DB8","DB06616(Bosutinib)","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","PF07714(Pkinase_Tyr)",14,"LEU A 273;VAL A 281;ALA A 293;LYS A 295;GLU A 310;MET A 314;VAL A 323;ILE A 336;THR A 338;TYR A 340;MET A 341;GLY A 344;LEU A 393;ASP A 404","DB8 A 601\r"],["4MXO_B_DB8B601","4mxo","DB8","DB06616(Bosutinib)","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","no annotation",13,"LEU B 273;VAL B 281;ALA B 293;LYS B 295;GLU B 310;VAL B 323;ILE B 336;THR B 338;TYR B 340;MET B 341;GLY B 344;LEU B 393;ASP B 404","DB8 B 601\r"],["4MXX_A_DB8A601","4mxx","DB8","DB06616(Bosutinib)","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","PF07714(Pkinase_Tyr)",13,"LEU A 273;ALA A 293;LYS A 295;GLU A 310;MET A 314;VAL A 323;ILE A 336;THR A 338;TYR A 340;MET A 341;GLY A 344;LEU A 393;THR A 403","DB8 A 601\r"],["4MXX_B_DB8B601","4mxx","DB8","DB06616(Bosutinib)","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","no annotation",12,"LEU B 273;VAL B 281;ALA B 293;LYS B 295;VAL B 323;THR B 338;TYR B 340;MET B 341;GLY B 344;LEU B 393;THR B 403;PHE B 405","DB8 B 601\r"],["4MXY_A_DB8A601","4mxy","DB8","DB06616(Bosutinib)","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","PF07714(Pkinase_Tyr)",13,"LEU A 273;VAL A 281;ALA A 293;LYS A 295;GLU A 310;VAL A 323;ILE A 336;MET A 338;TYR A 340;MET A 341;GLY A 344;LEU A 393;ASP A 404","DB8 A 601\r"],["4MXY_B_DB8B601","4mxy","DB8","DB06616(Bosutinib)","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","no annotation",13,"LEU B 273;VAL B 281;ALA B 293;LYS B 295;GLU B 310;VAL B 323;MET B 338;TYR B 340;MET B 341;GLY B 344;LEU B 393;ALA B 403;ASP B 404","DB8 B 601\r"],["4MXZ_A_DB8A601","4mxz","DB8","DB06616(Bosutinib)","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","PF07714(Pkinase_Tyr)",13,"LEU A 273;VAL A 281;ALA A 293;LYS A 295;GLU A 310;VAL A 323;ILE A 336;MET A 338;TYR A 340;MET A 341;GLY A 344;LEU A 393;ASP A 404","DB8 A 601\r"],["4MXZ_B_DB8B601","4mxz","DB8","DB06616(Bosutinib)","Homo sapiens","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","no annotation",13,"LEU B 273;VAL B 281;ALA B 293;LYS B 295;GLU B 310;VAL B 323;MET B 338;TYR B 340;MET B 341;GLY B 344;LEU B 393;ALA B 403;ASP B 404","DB8 B 601\r"],["4OTW_A_DB8A1101","4otw","DB8","DB06616(Bosutinib)","Homo sapiens","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3","PF07714(Pkinase_Tyr)",15,"LEU A 696;VAL A 704;CYS A 721;LYS A 723;VAL A 753;LEU A 766;THR A 768;TYR A 770;LEU A 771;GLY A 774;ASN A 820;LEU A 822;ALA A 832;ASP A 833;VAL A 836","DB8 A1101\r"],["4QMN_A_DB8A401","4qmn","DB8","DB06616(Bosutinib)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE 24","PF00069(Pkinase)",13,"ILE A  30;ALA A  51;LYS A  53;GLU A  70;THR A  83;ILE A  97;MET A  99;TYR A 101;LEU A 102;LEU A 151;ALA A 161;ASP A 162;LYS A 295","DB8 A 401\r"],["5AJQ_A_DB8A800","5ajq","DB8","DB06616(Bosutinib)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE 10","PF00069(Pkinase)",16,"LEU A  42;GLY A  43;VAL A  50;ALA A  63;LYS A  65;ILE A 110;PHE A 112;CYS A 113;GLY A 116;GLU A 124;ASN A 162;LEU A 164;ALA A 174;ASP A 175;VAL A 178;SER A 179","DB8 A 800\r"],["5AJQ_B_DB8B800","5ajq","DB8","DB06616(Bosutinib)","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE 10","no annotation",10,"LEU B  42;ALA B  63;LYS B  65;ILE B 110;PHE B 112;CYS B 113;GLY B 116;LEU B 164;ALA B 174;ASP B 175","DB8 B 800\r"],["5I9X_A_DB8A1001","5i9x","DB8","DB06616(Bosutinib)","Homo sapiens","EPHRIN TYPE-A RECEPTOR 2","PF07714(Pkinase_Tyr)",13,"ILE A 619;ALA A 644;LYS A 646;GLU A 663;ILE A 676;ILE A 690;THR A 692;TYR A 694;MET A 695;GLY A 698;GLU A 706;LEU A 746;SER A 756","DB8 A1001\r"],["5VC3_A_DB8A601","5vc3","DB8","DB06616(Bosutinib)","Homo sapiens","WEE1-LIKE PROTEIN KINASE","PF00069(Pkinase)",16,"GLU A 303;ILE A 305;GLY A 306;VAL A 313;ALA A 326;LYS A 328;GLU A 346;VAL A 360;ASN A 376;TYR A 378;CYS A 379;GLY A 382;ASP A 386;ASN A 431;PHE A 433;ASP A 463","DB8 A 601\r"],["5VCY_A_DB8A401","5vcy","DB8","DB06616(Bosutinib)","Homo sapiens","MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE","PF00069(Pkinase)",16,"LEU A 116;VAL A 124;ALA A 137;LYS A 139;GLU A 157;VAL A 171;LEU A 185;THR A 187;LEU A 189;CYS A 190;GLY A 191;PRO A 192;GLN A 196;ASN A 238;PHE A 240;ASP A 251","DB8 A 401\r"],["6FDY_U_DB8U301","6fdy","DB8","DB06616(Bosutinib)","-","-","no annotation",11,"LEU U  20;VAL U  28;ALA U  42;LYS U  44;VAL U  75;MET U  91;PHE U  93;CYS U  94;ASN U 142;LEU U 144;ASP U 157","DB8 U 301\r"],["6FDY_U_DB8U302","6fdy","DB8","DB06616(Bosutinib)","-","-","no annotation",9,"LEU U 173;PRO U 177;MET U 180;VAL U 185;PHE U 218;SER U 219;LEU U 221;GLU U 222;ILE U 225","DB8 U 302\r"]]