DRUG BINDING INTERFACES MAPPED TO '7tm_1'
List of Binding Interfaces (Click on the entry ID to view details of interfaces and pattern clusters) (Note that ASSAM search use only 3-12 residue containing patterns)DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
2Y00_A_Y00A601 | 2y00 | Y00 DB00841(Dobutamine) | Meleagrisgallopavo | BETA-1 ADRENERGICRECEPTOR | PF00001(7tm_1) | 16 | LEU A 101VAL A 102TRP A 117ASP A 121VAL A 122VAL A 125PHE A 201SER A 211SER A 215PHE A 306PHE A 307ASN A 310VAL A 326ASN A 329TRP A 330TYR A 333 | Y00 A 601 |
2Y01_A_Y00A601 | 2y01 | Y00 DB00841(Dobutamine) | Meleagrisgallopavo | BETA-1 ADRENERGICRECEPTOR | PF00001(7tm_1) | 12 | VAL A 102TRP A 117ASP A 121PHE A 201SER A 211PHE A 306PHE A 307ASN A 310VAL A 326ASN A 329TRP A 330TYR A 333 | Y00 A 601 |
2Y03_A_5FWA601 | 2y03 | 5FW DB01064(Isoprenaline) | Meleagrisgallopavo | BETA-1 ADRENERGICRECEPTOR | PF00001(7tm_1) | 12 | TRP A 117ASP A 121VAL A 122VAL A 125PHE A 201SER A 211SER A 215PHE A 306PHE A 307ASN A 310ASN A 329TYR A 333 | 5FW A 601 |
2Y04_A_68HA601 | 2y04 | 68H DB01001(Salbutamol)DB13139(Levosalbutamol) | Meleagrisgallopavo | BETA-1 ADRENERGICRECEPTOR | PF00001(7tm_1) | 11 | TRP A 117ASP A 121VAL A 122PHE A 201SER A 211SER A 215PHE A 306PHE A 307ASN A 310ASN A 329TYR A 333 | 68H A 601 |
2YDO_A_ADNA400 | 2ydo | ADN DB00640(Adenosine) | Homo sapiens | ADENOSINE RECEPTORA2A | PF00001(7tm_1) | 13 | VAL A 84LEU A 85THR A 88PHE A 168GLU A 169MET A 177TRP A 246LEU A 249ASN A 253MET A 270ILE A 274SER A 277HIS A 278 | ADN A 400 |
3D4S_A_TIMA401 | 3d4s | TIM DB00373(Timolol) | Escherichia virusT4;Homo sapiens | BETA-2 ADRENERGICRECEPTOR/T4-LYSOZYMECHIMERA | PF00001(7tm_1)PF00959(Phage_lysozyme) | 15 | TRP A 109THR A 110ASP A 113VAL A 114VAL A 117THR A 118SER A 203SER A 207TRP A 286PHE A 289PHE A 290ASN A 293TYR A 308ASN A 312TYR A 316 | TIM A 401 |
3NYA_A_JTZA1203 | 3nya | JTZ DB00866(Alprenolol) | Escherichia virusT4;Homo sapiens | BETA-2 ADRENERGICRECEPTOR, LYSOZYME | PF00001(7tm_1)PF00959(Phage_lysozyme) | 14 | TRP A 109THR A 110ASP A 113VAL A 114VAL A 117THR A 118SER A 203SER A 207TRP A 286PHE A 289PHE A 290ASN A 293ASN A 312TYR A 316 | JTZ A1203 |
3RFM_A_CFFA330 | 3rfm | CFF DB00201(Caffeine) | Homo sapiens | ADENOSINE RECEPTORA2A | PF00001(7tm_1) | 7 | VAL A 84PHE A 168MET A 177LEU A 249ASN A 253MET A 270ILE A 274 | CFF A 330 |
3RZE_A_D7VA1201 | 3rze | D7V DB01142(Doxepin) | Escherichia virusT4;Homo sapiens | HISTAMINE H1RECEPTOR, LYSOZYMECHIMERA | PF00001(7tm_1)PF00959(Phage_lysozyme) | 13 | ASP A 107TYR A 108SER A 111THR A 112ILE A 115TRP A 158THR A 194ASN A 198TRP A 428TYR A 431PHE A 432PHE A 435TYR A 458 | D7V A1201 |
3VW7_A_VPXA2001 | 3vw7 | VPX DB09030(Vorapaxar) | Escherichia virusT4;Homo sapiens | PROTEINASE-ACTIVATEDRECEPTOR 1, LYSOZYME | PF00001(7tm_1)PF00959(Phage_lysozyme) | 16 | TYR A 183TYR A 187PRO A 236LEU A 237HIS A 255LEU A 258LEU A 262PHE A 271LEU A 332LEU A 333HIS A 336TYR A 337LEU A 340ALA A 349ALA A 352TYR A 353 | VPX A2001 |
4AMJ_A_CVDA1359 | 4amj | CVD DB01136(Carvedilol) | Meleagrisgallopavo | BETA-1 ADRENERGICRECEPTOR | PF00001(7tm_1) | 14 | TRP A 117ASP A 121VAL A 122VAL A 125TYR A 207SER A 211SER A 215TRP A 303PHE A 306PHE A 307ASN A 310ASN A 329TRP A 330TYR A 333 | CVD A1359 |
4DAJ_A_0HKA2000 | 4daj | 0HK DB01409(Tiotropium) | Escherichia virusT4;Rattus norvegicus | MUSCARINICACETYLCHOLINERECEPTOR M3,LYSOZYME | PF00001(7tm_1)PF00959(Phage_lysozyme) | 13 | ASP A 147TYR A 148SER A 151ASN A 152TRP A 199THR A 231ALA A 238PHE A 239TRP A 503TYR A 506ASN A 507TYR A 529CYS A 532 | 0HK A2000 |
4IAQ_A_2GMA2001 | 4iaq | 2GM DB00320(Dihydroergotamine) | Escherichia coli;Homo sapiens | CHIMERA PROTEIN OFHUMAN5-HYDROXYTRYPTAMINERECEPTOR 1B AND E.COLI SOLUBLECYTOCHROME B562 | PF00001(7tm_1)PF07361(Cytochrom_B562) | 18 | TRP A 125LEU A 126ASP A 129ILE A 130CYS A 133THR A 134VAL A 200VAL A 201SER A 212ALA A 216TRP A 327PHE A 330PHE A 331MET A 337LEU A 348PHE A 351ASP A 352THR A 355 | 2GM A2001 |
4IAR_A_ERMA2001 | 4iar | ERM DB00696(Ergotamine) | Escherichia coli;Homo sapiens | CHIMERA PROTEIN OFHUMAN5-HYDROXYTRYPTAMINERECEPTOR 1B AND E.COLI SOLUBLECYTOCHROME B562 | PF00001(7tm_1)PF07361(Cytochrom_B562) | 19 | TRP A 125LEU A 126ASP A 129ILE A 130CYS A 133THR A 134VAL A 200VAL A 201SER A 212ALA A 216TRP A 327PHE A 330PHE A 331SER A 334MET A 337LEU A 348PHE A 351ASP A 352THR A 355 | ERM A2001 |
4IB4_A_ERMA2001 | 4ib4 | ERM DB00696(Ergotamine) | Escherichia coli;Homo sapiens | CHIMERA PROTEIN OFHUMAN5-HYDROXYTRYPTAMINERECEPTOR 2B AND E.COLI SOLUBLECYTOCHROME B562 | PF00001(7tm_1)PF07361(Cytochrom_B562) | 19 | LEU A 132ASP A 135VAL A 136SER A 139THR A 140VAL A 208LEU A 209LYS A 211MET A 218ALA A 225TRP A 337PHE A 340PHE A 341ASN A 344LEU A 347VAL A 348GLN A 359LEU A 362VAL A 366 | ERM A2001 |
4LDO_A_ALEA1402 | 4ldo | ALE DB00668(Epinephrine) | Escherichia virusT4;Homo sapiens | LYSOZYME, BETA-2ADRENERGIC RECEPTOR | PF00001(7tm_1)PF00959(Phage_lysozyme) | 10 | ASP A1113VAL A1114VAL A1117PHE A1193SER A1203SER A1207PHE A1289ASN A1293ASN A1312TYR A1316 | ALE A1402 |
4MBS_A_MRVA1101 | 4mbs | MRV DB04835(Maraviroc) | Clostridiumpasteurianum;Homo sapiens | CHIMERA PROTEIN OFC-C CHEMOKINERECEPTOR TYPE 5 ANDRUBREDOXIN | PF00001(7tm_1)PF00301(Rubredoxin) | 19 | TYR A 37TRP A 86TYR A 89TYR A 108PHE A 109PHE A 112PHE A 182LYS A 191GLN A 194THR A 195ILE A 198TRP A 248TYR A 251LEU A 255THR A 259MET A 279GLU A 283THR A 284MET A 287 | MRV A1101 |
4NC3_A_ERMA1202 | 4nc3 | ERM DB00696(Ergotamine) | Escherichia coli;Homo sapiens | CHIMERA PROTEIN OFHUMAN5-HYDROXYTRYPTAMINERECEPTOR 2B AND E.COLI SOLUBLECYTOCHROME B562 | PF00001(7tm_1)PF07361(Cytochrom_B562) | 18 | LEU A 132ASP A 135VAL A 136SER A 139THR A 140VAL A 208LEU A 209PHE A 217MET A 218ALA A 225TRP A 337PHE A 340ASN A 344LEU A 347GLN A 359LEU A 362GLU A 363VAL A 366 | ERM A1202 |
4S0V_A_SUVA2001 | 4s0v | SUV DB09034(Suvorexant) | Homo sapiens;Pyrococcus abyssi | HUMAN OREXINRECEPTOR TYPE 2FUSION PROTEIN TO P.ABYSII GLYCOGENSYNTHASE | PF00001(7tm_1)PF00534(Glycos_transf_1) | 17 | THR A 111VAL A 114TRP A 120ILE A 130PRO A 131GLN A 134THR A 135VAL A 138GLN A 187GLU A 212HIS A 224TYR A 317ILE A 320ASN A 324HIS A 350VAL A 353TYR A 354 | SUV A2001 |
4U14_A_0HKA2000 | 4u14 | 0HK DB01409(Tiotropium) | Escherichia virusT4;Rattus norvegicus | MUSCARINICACETYLCHOLINERECEPTORM3,ENDOLYSIN,MUSCARINIC ACETYLCHOLINERECEPTOR M3 | PF00001(7tm_1)PF00959(Phage_lysozyme) | 16 | ILE A 116ASP A 147TYR A 148SER A 151ASN A 152TRP A 199LEU A 225THR A 231ALA A 235ALA A 238PHE A 239TRP A 503TYR A 506ASN A 507TYR A 529CYS A 532 | 0HK A2000 |
4U15_A_0HKA2001 | 4u15 | 0HK DB01409(Tiotropium) | Escherichia virusT4;Rattus norvegicus | MUSCARINICACETYLCHOLINERECEPTORM3,LYSOZYME,MUSCARINIC ACETYLCHOLINERECEPTOR M3 | PF00001(7tm_1)PF00959(Phage_lysozyme) | 15 | ASP A 147TYR A 148SER A 151ASN A 152TRP A 199THR A 231THR A 234ALA A 235ALA A 238PHE A 239TRP A 503TYR A 506ASN A 507TYR A 529CYS A 532 | 0HK A2001 |
4ZJ8_A_SUVA2001 | 4zj8 | SUV DB09034(Suvorexant) | Homo sapiens;Pyrococcus abyssi | HUMAN OX1R FUSIONPROTEIN TO P.ABYSIIGLYCOGEN SYNTHASE | PF00001(7tm_1)PF00534(Glycos_transf_1) | 18 | ALA A 102SER A 103VAL A 106TRP A 112ILE A 122PRO A 123GLN A 126VAL A 130GLN A 179MET A 183GLU A 204HIS A 216PHE A 219ILE A 314ASN A 318HIS A 344VAL A 347TYR A 348 | SUV A2001 |
4ZUD_A_OLMA1201 | 4zud | OLM DB00275(Olmesartan) | Escherichia coli;Homo sapiens | CHIMERA PROTEIN OFSOLUBLE CYTOCHROMEB562 AND TYPE-1ANGIOTENSIN IIRECEPTOR | PF00001(7tm_1)PF07361(Cytochrom_B562) | 9 | TYR A 35PHE A 77TRP A 84VAL A 108SER A 109LEU A 112ARG A 167ILE A 288TYR A 292 | OLM A1201 |
5CXV_A_0HKA501 | 5cxv | 0HK DB01409(Tiotropium) | Escherichia virusT4;Homo sapiens | MUSCARINICACETYLCHOLINERECEPTORM1,ENDOLYSIN,MUSCARINIC ACETYLCHOLINERECEPTOR M1 | PF00001(7tm_1)PF00959(Phage_lysozyme) | 15 | ASP A 105TYR A 106SER A 109GLN A 110TRP A 157THR A 189THR A 192ALA A 193ALA A 196PHE A 197TRP A 378TYR A 381ASN A 382TYR A 404CYS A 407 | 0HK A 501 |
5DSG_A_0HKA1201 | 5dsg | 0HK DB01409(Tiotropium) | Escherichia virusT4;Homo sapiens | MUSCARINICACETYLCHOLINERECEPTORM4,ENDOLYSIN,ENDOLYSIN,MUSCARINICACETYLCHOLINERECEPTOR M4 | PF00001(7tm_1)PF00959(Phage_lysozyme) | 15 | ASP A 112TYR A 113SER A 116ASN A 117TRP A 164LEU A 190THR A 196THR A 199ALA A 203PHE A 204TRP A 413TYR A 416ASN A 417TYR A 439CYS A 442 | 0HK A1201 |
5MZJ_A_TEPA2401 | 5mzj | TEP DB00277(Theophylline) | Escherichia coli;Homo sapiens | ADENOSINE RECEPTORA2A,SOLUBLECYTOCHROMEB562,ADENOSINERECEPTOR A2A | PF00001(7tm_1)PF07361(Cytochrom_B562) | 8 | LEU A 85PHE A 168GLU A 169MET A 177LEU A 249ASN A 253MET A 270ILE A 274 | TEP A2401 |
5MZP_A_CFFA2401 | 5mzp | CFF DB00201(Caffeine) | Escherichia coli;Homo sapiens | ADENOSINE RECEPTORA2A,SOLUBLECYTOCHROMEB562,ADENOSINERECEPTOR A2A | PF00001(7tm_1)PF07361(Cytochrom_B562) | 9 | ILE A 66VAL A 84PHE A 168GLU A 169MET A 177LEU A 249ASN A 253MET A 270ILE A 274 | CFF A2401 |
5TUD_A_ERMA2001 | 5tud | ERM DB00696(Ergotamine) | Escherichia coli;Homo sapiens | 5-HYDROXYTRYPTAMINERECEPTOR 2B,SOLUBLECYTOCHROME B562CHIMERA | PF00001(7tm_1)PF07361(Cytochrom_B562) | 19 | LEU A 132ASP A 135VAL A 136SER A 139THR A 140VAL A 208LEU A 209LYS A 211MET A 218ALA A 225PHE A 340PHE A 341ASN A 344LEU A 347VAL A 348GLN A 359LEU A 362GLU A 363VAL A 366 | ERM A2001 |
5UIG_A_EDTA501 | 5uig | EDT DB00974(EdeticAcid) | Escherichia coli;Homo sapiens | ADENOSINE RECEPTORA2A,SOLUBLECYTOCHROMEB562,ADENOSINERECEPTOR A2A | PF00001(Cytochrom_B562)PF07361(7tm_1) | 6 | ASN A 39THR A 41ASN A 42ARG A 102ILE A 292GLU A 294 | EDT A 501 |
5XPR_A_K86A1201 | 5xpr | K86 DB00559(Bosentan) | Escherichia virusT4;Homo sapiens | ENDOTHELIN BRECEPTOR,ENDOLYSIN,ENDOTHELIN B RECEPTOR | PF00001(7tm_1)PF00959(Phage_lysozyme) | 16 | HIS A 150ASP A 154PRO A 178GLN A 181LYS A 182VAL A 185GLU A 236LYS A 273LEU A 277TYR A 281TRP A 336LEU A 339HIS A 340ARG A 343ILE A 372ALA A 375 | K86 A1201 |
6A93_A_8NUA3001 | 6a93 | 8NU DB00734(Risperidone) | Escherichia coli;Homo sapiens | 5-HYDROXYTRYPTAMINERECEPTOR 2A,SOLUBLECYTOCHROME B562 | PF00001(7tm_1) | 14 | SER A 131TRP A 151ASP A 155SER A 159THR A 160ILE A 163LEU A 228PHE A 332TRP A 336PHE A 339PHE A 340LEU A 362ASN A 363TYR A 370 | 8NU A3001 |
6A94_A_ZOTA3001 | 6a94 | ZOT DB09225(Zotepine) | Escherichia coli;Homo sapiens | 5-HYDROXYTRYPTAMINERECEPTOR 2A,SOLUBLECYTOCHROME B562 | PF00001(7tm_1) | 13 | TRP A 151ASP A 155SER A 159LEU A 229VAL A 235GLY A 238SER A 242PHE A 332TRP A 336PHE A 339PHE A 340ASN A 343VAL A 366 | ZOT A3001 |
6AK3_A_P2EA1201 | 6ak3 | P2E DB00917(Dinoprostone) | Escherichia coli;Homo sapiens | PROSTAGLANDIN E2RECEPTOR EP3SUBTYPE,SOLUBLECYTOCHROME B562 | PF00001(7tm_1) | 16 | PRO A 55MET A 58GLN A 103THR A 106THR A 107VAL A 110TYR A 114MET A 137GLY A 141THR A 206TRP A 207LEU A 329VAL A 332ARG A 333SER A 336GLN A 339 | P2E A1201 |
6CM4_A_8NUA2001 | 6cm4 | 8NU DB00734(Risperidone) | Homo sapiens;Escherichia virusT4 | D(2) DOPAMINERECEPTOR, ENDOLYSINCHIMERA | PF00001(7tm_1)PF00959(Phage_lysozyme) | 16 | TRP A 100PHE A 110ASP A 114VAL A 115CYS A 118THR A 119ALA A 122SER A 193SER A 197PHE A 382TRP A 386PHE A 389PHE A 390TYR A 408THR A 412TYR A 416 | 8NU A2001 |
6DRX_A_H8GA1201 | 6drx | H8G DB00589(Lisuride) | Escherichia coli;Homo sapiens | 5HT2B RECEPTOR, BRILCHIMERA | PF00001(Cytochrom_B562)PF07361(7tm_1) | 13 | TRP A 131LEU A 132ASP A 135VAL A 136SER A 139THR A 140PHE A 217ALA A 225TRP A 337PHE A 340ASN A 344VAL A 366TYR A 370 | H8G A1201 |
6DRY_A_H8DA2001 | 6dry | H8D DB00353(Methylergometrine) | Escherichia coli;Homo sapiens | 5HT2B RECEPTOR, BRILCHIMERA | PF00001(Cytochrom_B562)PF07361(7tm_1) | 11 | ASP A 135VAL A 136SER A 139THR A 140VAL A 208LEU A 209ALA A 225PHE A 340GLN A 359VAL A 366TYR A 370 | H8D A2001 |
6DRZ_A_H8JA1206 | 6drz | H8J DB00247(Methysergide) | Escherichia coli;Homo sapiens | 5HT2B RECEPTOR, BRILCHIMERA | PF00001(Cytochrom_B562)PF07361(7tm_1) | 13 | ASP A 135VAL A 136SER A 139THR A 140VAL A 208LEU A 209PHE A 217GLY A 225PHE A 340PHE A 341ASN A 344VAL A 366TYR A 370 | H8J A1206 |
6H7J_A_5FWA401 | 6h7j | 5FW DB01064(Isoprenaline) | Meleagrisgallopavo | BETA-1 ADRENERGICRECEPTOR | PF00001(7tm_1) | 13 | TRP A 117THR A 118ASP A 121VAL A 122VAL A 125SER A 211SER A 212SER A 215PHE A 306PHE A 307ASN A 310ASN A 329TYR A 333 | 5FW A 401 |
6H7L_A_Y00A406 | 6h7l | Y00 DB00841(Dobutamine) | Meleagrisgallopavo | BETA-1 ADRENERGICRECEPTOR | PF00001(7tm_1) | 18 | GLY A 98LEU A 101VAL A 102TRP A 117THR A 118ASP A 121VAL A 122VAL A 125PHE A 201SER A 211SER A 215PHE A 306PHE A 307ASN A 310VAL A 326ASN A 329TRP A 330TYR A 333 | Y00 A 406 |
6H7M_A_68HA504 | 6h7m | 68H DB01001(Salbutamol)DB13139(Levosalbutamol) | Meleagrisgallopavo | BETA-1 ADRENERGICRECEPTOR | PF00001(7tm_1) | 13 | TRP A 117THR A 118ASP A 121VAL A 122VAL A 125PHE A 201SER A 211SER A 215PHE A 306PHE A 307ASN A 310ASN A 329TYR A 333 | 68H A 504 |
6HLO_A_GBQA1501 | 6hlo | GBQ DB00673(Aprepitant) | Homo sapiens;Pyrococcus abyssi | SUBSTANCE-PRECEPTOR,GLGAGLYCOGENSYNTHASE,SUBSTANCE-PRECEPTOR | PF00001(7tm_1)PF00534(Glycos_transf_1) | 21 | MET A 81ASN A 89ASN A 109PRO A 112ILE A 113ILE A 116GLN A 165ILE A 182TRP A 184GLU A 193TYR A 196HIS A 197VAL A 200THR A 201ILE A 204TRP A 261PHE A 264HIS A 265PHE A 268MET A 291MET A 295 | GBQ A1501 |
6HLP_A_GAWA1501 | 6hlp | GAW DB09048(Netupitant) | Homo sapiens;Pyrococcus abyssi | SUBSTANCE-PRECEPTOR,SUBSTANCE-PRECEPTOR | PF00001(7tm_1)PF00534(Glycos_transf_1) | 17 | ASN A 89ASN A 109PRO A 112ILE A 113ILE A 116GLN A 165HIS A 197VAL A 200THR A 201ILE A 204TRP A 261PHE A 264HIS A 265PHE A 268PRO A 271TYR A 272MET A 295 | GAW A1501 |
6IBL_A_H98A501 | 6ibl | H98 DB01274(Arformoterol) | Escherichia coli;Meleagrisgallopavo | THIOREDOXIN 1,BETA-1ADRENERGIC RECEPTOR | PF00001(Thioredoxin)PF00085(7tm_1) | 16 | TRP A 117THR A 118ASP A 121VAL A 122VAL A 125ASP A 200PHE A 201SER A 211SER A 215TRP A 303PHE A 306PHE A 307ASN A 310VAL A 326ASN A 329TYR A 333 | H98 A 501 |
6J20_A_GBQA1201 | 6j20 | GBQ DB00673(Aprepitant) | Homo sapiens;Escherichia virusT4 | SUBSTANCE-PRECEPTOR,ENDOLYSIN | PF00001(7tm_1)PF00959(Phage_lysozyme) | 19 | ASN A 89ASN A 109PRO A 112ILE A 113VAL A 116GLN A 165ILE A 182TRP A 184GLU A 193TYR A 196HIS A 197VAL A 200THR A 201ILE A 204TRP A 261PHE A 264HIS A 265PHE A 268MET A 291 | GBQ A1201 |
6J21_A_GBQA1201 | 6j21 | GBQ DB00673(Aprepitant) | Homo sapiens;Escherichia virusT4 | SUBSTANCE-PRECEPTOR,ENDOLYSIN | PF00001(Phage_lysozyme)PF00959(7tm_1) | 16 | ASN A 89ASN A 109PRO A 112ILE A 113VAL A 116ILE A 182TRP A 184GLU A 193HIS A 197VAL A 200THR A 201TRP A 261PHE A 264HIS A 265PHE A 268MET A 291 | GBQ A1201 |
6MXT_A_K5YA1401 | 6mxt | K5Y DB00938(Salmeterol) | Homo sapiens;Escherichia virusT4 | ENDOLYSIN, BETA-2ADRENERGIC RECEPTORCHIMERA | PF00001(Phage_lysozyme)PF00959(7tm_1) | 15 | TRP A1109ASP A1113VAL A1114VAL A1117ASP A1192PHE A1193SER A1203SER A1207PHE A1289ASN A1293HIS A1296TYR A1308ILE A1309ASN A1312TYR A1316 | K5Y A1401 |