DRUG BINDING INTERFACES MAPPED TO 'Streptococcus pneumoniae'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
Filter list by:
DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
1F9G_A_ASCA950 1f9g ASC

DB00126
(Vitamin
C) 		Streptococcus
pneumoniae 		HYALURONATE LYASE PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		7 ARG A 243
ASN A 290
TRP A 292
TYR A 408
ARG A 462
ARG A 466
ASN A 580
 ASC A 950
2DPM_A_SAMA300 2dpm SAM

DB00118
(S-
Adenosylmethionine) 		Streptococcus
pneumoniae 		PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1) 		PF02086
(MethyltransfD12) 		14 TRP A  17
GLY A  20
LYS A  21
PHE A  43
GLY A  45
GLY A  46
ALA A  48
ASP A  62
PHE A  63
ASN A  64
ASP A 177
PHE A 178
ASP A 194
PRO A 196
 SAM A 300
2HMA_A_SAMA375 2hma SAM

DB00118
(S-
Adenosylmethionine) 		Streptococcus
pneumoniae 		PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE 		PF03054
(tRNA_Me_trans) 		11 GLY A  12
SER A  14
SER A  19
ASP A 100
ASN A 104
LYS A 108
THR A 126
GLY A 127
HIS A 128
GLN A 152
PHE A 155
 SAM A 375
2X8O_A_OINA1314 2x8o OIN

DB00424
(Hyoscyamine)
DB00572
(Atropine) 		Streptococcus
pneumoniae 		CHOLINE-BINDING
PROTEIN F 		PF01473
(CW_binding_1) 		5 LYS A  10
ASP A  11
ARG A  13
TYR A  15
GLU A  41
 OIN A1314
2X8O_A_OINA1317 2x8o OIN

DB00424
(Hyoscyamine)
DB00572
(Atropine) 		Streptococcus
pneumoniae 		CHOLINE-BINDING
PROTEIN F 		PF01473
(CW_binding_1) 		4 TRP A 194
TRP A 201
TYR A 222
MET A 231
 OIN A1317
2X8P_A_OINA1313 2x8p OIN

DB00424
(Hyoscyamine)
DB00572
(Atropine) 		Streptococcus
pneumoniae 		CHOLINE-BINDING
PROTEIN F 		PF01473
(CW_binding_1) 		4 TRP A 194
LYS A 196
TRP A 201
TYR A 222
 OIN A1313
2X8P_A_OINA1315 2x8p OIN

DB00424
(Hyoscyamine)
DB00572
(Atropine) 		Streptococcus
pneumoniae 		CHOLINE-BINDING
PROTEIN F 		PF01473
(CW_binding_1) 		4 TRP A 163
TRP A 181
LYS A 227
ASN A 228
 OIN A1315
2YA7_A_ZMRA1776 2ya7 ZMR

DB00558
(Zanamivir) 		Streptococcus
pneumoniae 		NEURAMINIDASE A PF13088
(BNR_2) 		18 ARG A 332
ILE A 333
ASP A 349
ARG A 351
ASP A 357
ILE A 401
ASP A 402
ASP A 419
ILE A 427
PHE A 428
TYR A 575
LEU A 583
GLN A 587
GLU A 632
ARG A 648
TYR A 680
ARG A 706
TYR A 737
 ZMR A1776
2YA7_B_ZMRB1776 2ya7 ZMR

DB00558
(Zanamivir) 		Streptococcus
pneumoniae 		NEURAMINIDASE A no annotation 18 ARG B 332
ILE B 333
ASP B 349
ARG B 351
ASP B 357
ILE B 401
ASP B 402
ASP B 419
ILE B 427
PHE B 428
TYR B 575
LEU B 583
GLN B 587
GLU B 632
ARG B 648
TYR B 680
ARG B 706
TYR B 737
 ZMR B1776
2YA7_C_ZMRC1776 2ya7 ZMR

DB00558
(Zanamivir) 		Streptococcus
pneumoniae 		NEURAMINIDASE A no annotation 18 ARG C 332
ILE C 333
ASP C 349
ARG C 351
ASP C 357
ILE C 401
ASP C 402
ASP C 419
ILE C 427
PHE C 428
TYR C 575
LEU C 583
GLN C 587
GLU C 632
ARG C 648
TYR C 680
ARG C 706
TYR C 737
 ZMR C1776
2YA7_D_ZMRD1776 2ya7 ZMR

DB00558
(Zanamivir) 		Streptococcus
pneumoniae 		NEURAMINIDASE A no annotation 18 ARG D 332
ILE D 333
ASP D 349
ARG D 351
ASP D 357
ILE D 401
ASP D 402
ASP D 419
ILE D 427
PHE D 428
TYR D 575
LEU D 583
GLN D 587
GLU D 632
ARG D 648
TYR D 680
ARG D 706
TYR D 737
 ZMR D1776
3FOF_F_MFXF0 3fof MFX

DB00218
(Moxifloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A 		no annotation 3 GLY B  77
SER B  79
SER B  80
 MFX F   0
3FOF_H_MFXH0 3fof MFX

DB00218
(Moxifloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		4 GLY A  77
SER A  79
SER A  80
ARG C 456
 MFX H   0
3IX9_A_MTXA200 3ix9 MTX

DB00563
(Methotrexate) 		Streptococcus
pneumoniae 		DIHYDROFOLATE
REDUCTASE 		PF00186
(DHFR_1)
no annotation 		13 ILE A   8
TRP A   9
ALA A  10
ASP B  20
LEU A  23
GLU A  30
LEU A  31
GLN A  32
LYS A  35
LEU A  58
ARG A  61
VAL A 100
THR A 119
 MTX A 200
3IX9_B_MTXB200 3ix9 MTX

DB00563
(Methotrexate) 		Streptococcus
pneumoniae 		DIHYDROFOLATE
REDUCTASE 		PF00186
(DHFR_1)
no annotation 		14 ILE B   8
TRP B   9
ALA B  10
ARG A  22
LEU B  23
GLU B  30
LEU B  31
GLN B  32
LYS B  35
ARG B  56
LEU B  58
ARG B  61
VAL B 100
THR B 119
 MTX B 200
3K9F_F_LFXF0 3k9f LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		5 SER A  79
ARG B 117
ARG C 456
GLY C 457
GLU C 475
 LFX F   0
3K9F_H_LFXH0 3k9f LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		PF00521
(DNA_topoisoIV)
no annotation 		6 SER B  79
ARG A 117
ARG D 456
GLY D 457
GLU D 474
GLU D 475
 LFX H   0
3KU1_A_SAMA226 3ku1 SAM

DB00118
(S-
Adenosylmethionine) 		Streptococcus
pneumoniae 		SAM-DEPENDENT
METHYLTRANSFERASE 		None
PF04816
(TrmK) 		14 ARG A   5
LEU A   6
GLY A  23
ARG B  36
GLU A  46
VAL A  47
PRO A  51
ASN A  74
GLY A  75
ALA A  91
GLY A  92
MET A  93
LEU A  97
ILE A 101
 SAM A 226
3KU1_C_SAMC226 3ku1 SAM

DB00118
(S-
Adenosylmethionine) 		Streptococcus
pneumoniae 		SAM-DEPENDENT
METHYLTRANSFERASE 		None 14 ARG C   5
LEU C   6
GLY C  23
ASP C  25
ARG D  36
GLU C  46
VAL C  47
PRO C  51
GLY C  75
ALA C  91
GLY C  92
MET C  93
LEU C  97
ILE C 101
 SAM C 226
3KU1_G_SAMG226 3ku1 SAM

DB00118
(S-
Adenosylmethionine) 		Streptococcus
pneumoniae 		SAM-DEPENDENT
METHYLTRANSFERASE 		None 13 ARG G   5
LEU G   6
GLY G  23
ASP G  25
GLU G  46
VAL G  47
PRO G  51
ASN G  74
GLY G  75
ALA G  91
GLY G  92
LEU G  97
ILE G 101
 SAM G 226
3KU1_H_SAMH226 3ku1 SAM

DB00118
(S-
Adenosylmethionine) 		Streptococcus
pneumoniae 		SAM-DEPENDENT
METHYLTRANSFERASE 		None 13 ARG H   5
LEU H   6
GLY H  23
ASP H  25
GLU H  46
VAL H  47
VAL H  48
PRO H  51
GLY H  75
ALA H  91
MET H  93
LEU H  97
ILE H 101
 SAM H 226
3O94_A_NCAA192 3o94 NCA

DB02701
(Nicotinamide) 		Streptococcus
pneumoniae 		NICOTINAMIDASE PF00857
(Isochorismatase) 		11 ASP A   9
PHE A  14
LEU A  21
ASP A  53
GLU A  64
PHE A  68
HIS A  71
TYR A 106
LEU A 132
ILE A 135
SER A 136
 NCA A 192
3O94_B_NCAB192 3o94 NCA

DB02701
(Nicotinamide) 		Streptococcus
pneumoniae 		NICOTINAMIDASE None 11 ASP B   9
PHE B  14
LEU B  21
ASP B  53
GLU B  64
PHE B  68
HIS B  71
TYR B 106
LEU B 132
ILE B 135
SER B 136
 NCA B 192
3O94_C_NCAC192 3o94 NCA

DB02701
(Nicotinamide) 		Streptococcus
pneumoniae 		NICOTINAMIDASE None 11 ASP C   9
PHE C  14
LEU C  21
ASP C  53
GLU C  64
PHE C  68
HIS C  71
TYR C 106
LEU C 132
ILE C 135
SER C 136
 NCA C 192
3O94_D_NCAD192 3o94 NCA

DB02701
(Nicotinamide) 		Streptococcus
pneumoniae 		NICOTINAMIDASE None 11 ASP D   9
PHE D  14
LEU D  21
ASP D  53
GLU D  64
PHE D  68
HIS D  71
TYR D 106
LEU D 132
ILE D 135
SER D 136
 NCA D 192
3RAE_F_LFXF101 3rae LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		4 SER A  79
ARG C 456
GLY C 457
GLU C 474
 LFX F 101
3RAE_H_LFXH101 3rae LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		no annotation 5 SER B  79
ARG D 456
GLY D 457
GLU D 474
GLU D 475
 LFX H 101
4EYS_A_ACTA402 4eys ACT

DB03166
(Acetic
acid) 		Streptococcus
pneumoniae 		MCCC FAMILY PROTEIN PF02016
(Peptidase_S66) 		6 SER A 109
ASP A 110
SER A 212
ASP A 215
ARG A 221
GLU A 253
 ACT A 402
4JUO_F_LFXF101 4juo LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B;
E-SITE DNA 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c)
no annotation 		4 SER A  79
ARG C 456
GLY C 457
GLU C 474
 LFX F 101
4KOE_F_TR6F101 4koe TR6

DB00685
(Trovafloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B;
E-SITE DNA2 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 SER A  79
ARG B 117
GLY C 434
ASP C 435
ARG C 456
GLY C 457
 TR6 F 101
4KOE_H_TR6H101 4koe TR6

DB00685
(Trovafloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B;
E-SITE DNA4 		PF00521
(DNA_topoisoIV)
no annotation 		7 SER B  79
ARG A 117
GLY D 434
ASP D 435
ARG D 456
GLY D 457
GLU D 475
 TR6 H 101
4Z2C_F_MFXF101 4z2c MFX

DB00218
(Moxifloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		4 SER B  81
ARG C 456
GLY C 457
GLU C 475
 MFX F 101
4Z2C_H_MFXH101 4z2c MFX

DB00218
(Moxifloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00521
(DNA_topoisoIV)
no annotation 		4 SER A  81
ARG D 456
GLY D 457
GLU D 475
 MFX H 101
4Z2D_F_LFXF102 4z2d LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		4 SER B  81
ARG C 456
GLY C 457
GLU C 475
 LFX F 102
4Z2D_H_LFXH101 4z2d LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00521
(DNA_topoisoIV)
no annotation 		4 SER A  81
ARG D 456
GLY D 457
GLU D 475
 LFX H 101
4Z2E_F_TR6F101 4z2e TR6

DB00685
(Trovafloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		5 SER B  81
GLY C 434
ARG C 456
GLY C 457
GLU C 475
 TR6 F 101
4Z2E_H_TR6H101 4z2e TR6

DB00685
(Trovafloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00521
(DNA_topoisoIV)
no annotation 		5 SER A  81
GLY D 434
ARG D 456
GLY D 457
GLU D 475
 TR6 H 101
4Z3O_F_MFXF101 4z3o MFX

DB00218
(Moxifloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE;
E-SITE DNA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		5 ARG B 456
GLY B 457
GLU B 475
SER B1079
ARG A1117
 MFX F 101
4Z3O_H_MFXH101 4z3o MFX

DB00218
(Moxifloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE;
E-SITE DNA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		3 ARG A 456
GLU A 475
SER A1079
 MFX H 101
4Z53_F_TR6F101 4z53 TR6

DB00685
(Trovafloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A;
E-SITE DNA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 GLY A 434
ASP A 435
ARG A 456
GLY A 457
SER A1079
ARG B1117
 TR6 F 101
4Z53_H_TR6H101 4z53 TR6

DB00685
(Trovafloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A;
E-SITE DNA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		7 GLY B 434
ASP B 435
ARG B 456
GLY B 457
GLU B 475
SER B1079
ARG A1117
 TR6 H 101
5OJ0_A_9WTA801 5oj0 9WT

DB01413
(Cefepime) 		Streptococcus
pneumoniae 		PENICILLIN-BINDING
PROTEIN 2X 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		14 SER A 337
LYS A 340
ARG A 372
TRP A 374
ASN A 377
SER A 395
ASN A 397
GLN A 447
GLN A 452
THR A 526
SER A 548
GLY A 549
THR A 550
GLN A 552
 9WT A 801